Gene R08C7.8 in Caenorhabditis elegans

Synonym: CELE_R08C7.8, R08C7.8

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf3
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP171_AA protein Get Run
CeleP171_AA_9-300 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 12-301 1.5e-187 614.5 In-house 1-290 (290) alignment 
Range on Protein: 12-301
Range on HMM: 1-290/290.0
KRMIEHLLKWGVTDAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRY
|||||||||.||.|||.||.|..||||.|..|.||||.|.||.||.||||||||||||.||||||||||||.||||||||||||||.|||||||||||||
krmiehllkygvldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiry

PHLVHLLRGNHECMKMNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTCDEGLQVDLMWADPTQD
.. |||||||||..|.||||||.|||.||||.|.|.|||.||.||.||||||..||||||||||...||||.||||||..||||||||||||.|||||.|
skkvhllrgnhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrd

KCNTFAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPRM
|..|.|.|||||||||||.|||||.||||.||||||||||..|||||||.||.|||||||||.|||||.|||..||.|.|||..||.||.
kddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkprk
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 18-300 2.3e-168 551.3 In-house 1-282 (287) alignment 
Range on Protein: 18-300
Range on HMM: 1-282/287.0
LLKWGVTDAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHL
|||.||.|||.||.|...|||.|..|.||||.|.||.|||||||||||||.|.|.|.|||..||||.|||||||||||||.|||||||..||.||. |||
llkygvldafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhl

LRGNHECMKMNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTCDEGLQVDLMWADPTQDkCNTFA
||||||..|.|.||||.|||.|||..|...|...||.||||||||..||||||||||....|..|.||||||.|||.|||||||||.||||..| ..||.
lrGnhevkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd.aktfe

MNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPR
.||.||||||||.|..||.||||...|||||||||.||..|||.|..|||||||||.|.|||.||...||.|.||||.||.| 
lnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpe
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 15-301 9.8e-102 333.0 In-house 12-295 (298) alignment 
Range on Protein: 15-301
Range on HMM: 12-295/298.0
IEHLLKWGVTDAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHL
.  | .  .| . ..... ...|.|.. .|  .....|. ||.. ||||||   |.| ||  |.||.. .|||||||||| ...|| .||..||..||. 
svslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnn

VHLLRGNHECMKMNRLYGFYEELTRKR-GGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPltCDEGLQVDLMWADPTQDKc
. |||||||| ..|| |||||| .|.    |.. ..|.||| |||.| .|.||||||||.|.. .|......||.|  .   .| |..||.||||.. . 
ffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfds..keeslaidllwadpenav.

NTFaMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPRM
. . ....| .|||||.. . |.|.|| . |.|||| | |.|..|. .|| ||.||||.|||. .|. |.|.|..  ..||.||.|..
kgw.aensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
PP2Ac_SM00156 28-300 6.7e-99 323.3 In-house 2-270 (271) alignment 
Range on Protein: 28-300
Range on HMM: 2-270/271.0
TDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKM
........||.... ||  .....|..|.|.||||||||| |.| ..  |.||. ...||||||||| .| || ||||..||.||  |.|||||||. ..
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKpnTPLTCDEGLQVDLMWADPtQDKCNTFAMNKqRAISVV
|..|||.||. || | ...   ...|. |||.| |...|||||||.|.. .|..... ||.     ...|||..||.|.|| ..| ..|...| | .|||
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkr..vkekpeegllidllwsdp.eqkekgfqpsk.rglsvv

FGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPR
||.. ...||||. |.||.|||||..||..| ..||.||.||||.||.. .| .|...|... .||. .|.. 
FgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
subfamily_PPP1C_pd Subfamily PPP1C 27-300 2.1e-97 318.7 In-house 10-279 (282) alignment 
Range on Protein: 27-300
Range on HMM: 10-279/282.0
FTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMK
.. ..| ..|.||.. |.  |..|..|.|..||||||||.  |.|.|.. |.||. ..|||||||||| .| |. .||..|||.||. ..|||||||...
lkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesas

MNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPTQDkCNTFAMNKqRAISV
.||.||||.|  |. . ..|.....||| |||.| | ..|||.|||.|.. .| |  . ...| .    ..|| .||.|.|| ..  .... |. | .|.
inriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPle..vpekgllcdllWsdpdke.vlgwsend.rGvsf

VFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPR
.||.. ...||.|  |.||||||.| ..|..|  ... ||||||| |||.  |.||...|...  .||..|.|.
tfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpa
0045823 Metallo-dependent phosphatases 12-300 2.9e-92 302.7 In-house 31-324 (473) alignment 
Range on Protein: 12-300
Range on HMM: 31-324/473.0
KRMIEHLLKWGvtdAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRY
...||||.|.|    .. .... .|..| . ||  | .|... .|...||||||||.|.| .. .|.||. ...||||.||||  | || .||...||.|
dlliehlkkeg...llpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkiky

PHLVHLLRGNHECMKMNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTcdEGLQVDLMWADPtQD
|. |.|||||||.. .| ||||..|. .| | ........... |||.|..|..||..|||.| . ....  .....|.....  .|| .||.|.|| ..
pgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipd..dgllldllwsdP.we

KCNT------FAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKK------CVTVFSAPYYCGNDTNCGAIMHVSDSYeLSFTVLRP
.. .      | .| .| ....||......|||| || ||||.|.. .||...||..|      ..|||||| |||.  |..|......   .||....|
ddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdp

R
 
s
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 27-301 2.1e-89 292.3 In-house 6-276 (280) alignment 
Range on Protein: 27-301
Range on HMM: 6-276/280.0
FTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMK
  . .|....|| .  |.   .|..|. |....||.|||   |.| |. |..||  ..|||||||||| . .|| |||..||.|||    .||||||...
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

MNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPltCDEGLQVDLMWADPTQdKCNTFAMNkQRAISV
.|| |||..|  |.    .. ..|.....|||.| |. ||||||||.||.  |.. .. |..|  .   || |. ||.|||| . |   .| | .| .||
inrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfds..edeclamdllwadpen.kvtgwaen.srgvsv

VFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPRM
.||.. . |. .|| . ||.| |.| |.|..|. .|| ||||||| |.|. .|  |.. |..  ..|| ||.| .
ifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpal
PPP_3 28-296 8.3e-89 290.2 In-house 3-268 (271) alignment 
Range on Protein: 28-296
Range on HMM: 3-268/271.0
TDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKM
. ........|... |.  . ......|.|..|||||||| |.. |. .| .|. ..||||||||||.||.|| |||...||.||. |||||||||. ..
senelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqi

NRLYGFYEELT-RKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPltCDEGLQVDLMWADPTQDKcnTFAMNKQRAISV
|..|||..|.. .| | ..... |.||. |||.| . ...|..|||.|....|... | |.....   ..||. .||.. ......  ..  |..| ...
nkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkiev..peegklldlllssdpeke..eglenskrGagl

VFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTV
.||..  ..||.|  |.||.||||. .||...|...|.||||||| ||.. .| |||...... . .|..
lFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkq
0049330 Metallo-dependent phosphatases 10-299 3.6e-87 285.3 In-house 16-298 (309) alignment 
Range on Protein: 10-299
Range on HMM: 16-298/309.0
LAKRMIEHLLKWGVtdaFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKI
| ...||.|||...   .. ......|.|| . ||  | .|.....|...||||||||.|.| ....|.||  ...||||.||||  | || |||...|.
lldllielllklkl...lseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkl

RYPHLVHLLRGNHECMKMNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTCdeGLQVDLMWADPt
.||. |.|||||||.. .|.||||..|. || | ..|........ |||.|..|..|||.|||.| . ........|..| ..     || .||.|.|| 
lypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipld..gllcdllwsdp.

QDKCNTFAMNKqRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRP
.. ...||.|. | ..||||   ...||||.||.||.|.|.. ..|. ..|..|..|||||| |||.  |.||..........||....|
lpiregfapnp.rglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfep
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 23-300 1.3e-86 283.5 In-house 20-294 (299) alignment 
Range on Protein: 23-300
Range on HMM: 20-294/299.0
VTDAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNH
.| .  .... |. . | |..   ...|.|| || ..||||||   |.| ||  |.||.|.||||||||||| . .|.  ||.|.||.||.  ..|||||
ltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnh

ECMKMNRLYGFYEELTRK-RGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLtcDEGLQVDLMWADPTQDKCNtFAMNkQ
||  .||.||||||  .. .  |.|  .|. |. .||.  .| ||||||||.| . .. . .. | .|. |   .  |..||.|||| |   . .  |  
ecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdpp..npslgidllwadpdqsvkd.wlan.v

RAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPR
| .| ||||. . | ...|.. |. |||.| |.|..|. .|| ||.||||.|||.  |  |||.| .    .|.||.| 
rgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkpt
PPP_1 29-286 7.2e-81 264.3 In-house 3-264 (264) alignment 
Range on Protein: 29-286
Range on HMM: 3-264/264.0
DKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMN
 ........|... |.  . .|.|...||..||||||.| |.. | . | .|. ..|||||||||| .|.|. |||...|..||. ..|||||||. ...
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

RLYGFYEELT-RKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALK----KPNTPLTCDE-GLQVDLMWADPTQDKcnTFAMNKQR
. |||..|.  .| . .... ...||. |||.| . ..||..|||.|.. .. .. . ..     |..  .||.   .|| .. |.....  ..  | .|
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqe..eavansiR

AISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHV
 .. .||..  ..||.| .|.||.||||| .||..||...|.||.|||. |. . .| ||....
GagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
0053225 Metallo-dependent phosphatases 12-300 1.6e-80 263.6 In-house 10-291 (293) alignment 
Range on Protein: 12-300
Range on HMM: 10-291/293.0
KRMIEHLLKWGVtdaFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRY
...||.||.. .   .. ......|..| . ||  | .|... .|...|||||.||.|.. .. .|.||  ...||||.||||  | || .||...|..|
dllielllllkl...lseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalklly

PHLVHLLRGNHECMKMNRLYGFYEELTRKR-GGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLtcDEGLQVDLMWADPTq
|. |.|||||||.| .| ||||..|  ||  . ..|........ |||.|..|..||..|||.| . ..... . ...|  .   .|||  ||.| ||. 
pdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplrip..legllldllwsdpd.

dKCNTFAMNKQRAIsVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPR
   ....... ... ||||   ...|||| || ||.|.|.| ..|. ..|..|.||||||| |.|  .|.||........  .|....|.
.lwsgwlpsyrglg.vvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 30-301 7.7e-80 261.3 In-house 6-275 (284) alignment 
Range on Protein: 30-301
Range on HMM: 6-275/284.0
KQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMNR
... |.| .| | ..  | ...|. || |.||||||.  |.| ||  |.| . ..|||||||||| . .|  ||||.||. .|  . .|||||||  .|.
edvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

LYGFYEELTRKR-GGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTcDEGLQVDLMWADPTQDKcNTFAMNkQRAISVVF
 ||||||  |.     ..  .. || ..|| | |||||||||||.|.  .    ..|.|.|       . | .|..|.|||. . . .  |  | .| ||
iygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpe.pntlaidilwsdptnfq.kgwnpn.srgvsyvf

GQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPRM
|   |  .| .| . |.||||.| |.|..|. |.. ||.||||.|||.  |. |.|.|      || ||||| 
gsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprk
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 25-299 1.1e-78 257.5 In-house 6-282 (284) alignment 
Range on Protein: 25-299
Range on HMM: 6-282/284.0
DAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYP------PKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLL
. ...|... .  .|  ..   .  |..| |..|||||||| . |.  .|  |.|       . ..||||||||||  | || .|||.||...|. | ||
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHECMKMNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPTQdKCNTFAm
|||||   .|. ||||.|  ..   ...  .|  || .|||| |...|.|||||||..  . . ...|..|    . | |.  || |||| . . .... 
rgnhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpid..ipdigviadltwadpea.evegyk.

NKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRP
. .|    |||.| ...||||  | |.||||.| ..|..|. ..| ||.||||.|||.  | .|...|..  . |||||.|
esprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_PPZ_pd Subfamily PPZ 28-299 1.2e-77 254.4 In-house 26-293 (300) alignment 
Range on Protein: 28-299
Range on HMM: 26-293/300.0
TDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKM
 ...|  |  ||   .   ||.|..  .. ||||.|||   |.| |  .|.||. ..|||||||||| .|.|  |||.||||.||  . |||||||| ..
knseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanv

NRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPTqDKCNTFAMNkQRAISVV
 |.||||.|  |.   ..|. . . || |||.| |  .|.|.|||.|   || .  . . .|      | ||  ||.|.||| |  | .  | .| .| .
trvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptd..vpdfglindllwsdpt.dssnewedn.ergvsyc

FGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRP
. .  .. ||.|.|. |..||| | ..|..|. ..  ||||||| |||.  | ||.| ||.    || .| |
ynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 27-300 6.2e-77 251.6 In-house 8-277 (281) alignment 
Range on Protein: 27-300
Range on HMM: 8-277/281.0
FTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMK
.|...| ... ..|. .    |. ....||..|||.|.| . |.| |. .| .|. ...||||||||| .|.|| .|||..||||.. . |||||||  .
ytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

MNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLtcDEGLQVDLMWADPTQDKCNTFAmnKQRAISV
.|. ||||.|   | |  .| ..|. ||.||. | . .|.||||||.| .  . .  .   ||  .|  | || .||.||||...  . .|    | .| 
vnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnl..drGlviDllwadpdnkveewka..ssrGssf

VFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPR
.||.. .||  |.|.. ||.||| | |.|.. |  .| .||||.| ||   .|..|.. | .. ..|.  | | 
tfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpa
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 24-300 7.1e-76 248.3 In-house 20-295 (297) alignment 
Range on Protein: 24-300
Range on HMM: 20-295/297.0
TDAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHE
..  |....  .|. | . .|   .|..|. || ..||||||.  |.| |   |.||  ..||||||||||  | |  .||..||...|  . |||||||
skviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhe

CMKMNRLYGFYEELT-RKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTCDEGLQVDLMWADPTQDKCnTFaMNKQR
|  .|. ||||||   | .  ||.  .|.||| |||.  . ..|||||||.|       ....|.| . .    |.|  ||.||||       | |..||
cefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegkerlvadllwadpisgls.gf.menqr

AISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPR
   . ||.  . .   .. | |..|||.| |.|..|.  .| ||.||||.|||.  || |.| . .  . || .||| 
gagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 83-300 1.1e-72 237.9 In-house 102-315 (317) alignment 
Range on Protein: 83-300
Range on HMM: 102-315/317.0
QFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWES
..||||||||||  |.|| .|||..|..||. |.|||||||   .|. ||||.| ...   ...  .|..|| ||||| |...|||||||||..  . . 
kylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlkq

FKALKKPNTplTCDEGLQVDLMWADPTQDkCNTFAmNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGA
...||.|    . | |.  || |||| ..  .... . .|  . |||.| ...||||| | |.||||.| ..|..|. ..| ||.|||| |||.  | .|
ldklkrpld..ipdvGvladltwadpdae.vkgyk.esarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaa

IMHVSDSYELSFTVLRPR
...| .  ..|..|||| 
vlsvdkklkisinvlrpe
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 48-300 2e-69 227.2 In-house 1-256 (263) alignment 
Range on Protein: 48-300
Range on HMM: 1-256/263.0
AMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMNRLYGFYEELTRKRG-----
|.|... || |.|| ||| . |.| |.|.|   | |.|||||||||| .|.|| .|||  |.  |. .||||||||   .|. |||. || ..       
allelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevy

GRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPlTCDEGLQVDLMWADPTQDkCNTFAMNKQRAISVVFGQKGLDDFLKKLGL
  .. ....||. .|||| | .||||||||||   .| .  .|.  |    .    | .||.|||| .| .. |  || |||| |||.| .||. |.| .
esvynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplplet.akthplacdllwadpekd.akgfepnkiraisnvfgkkevddlckrldi

SLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPR
 ||||||.| . |. |. ... .|||||  |  .  |  |.. |    ||||  |.| 
dlivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpe
subfamily_PPP4C_pd Subfamily PPP4C 14-297 2.6e-69 226.6 In-house 6-282 (288) alignment 
Range on Protein: 14-297
Range on HMM: 6-282/288.0
MIEHLLKwgvTDAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPH
.||.| .   ..  ..... .. .||.  |     . .|. |.|. ||||||.  |.. |.  |  |. ..|||||.||||  | |  ||| ..|.||| 
qieklrr...celikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypd

LVHLLRGNHECMKMNRLYGFYEELTRKRGG-RMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPTQDK
 ..|.|||||. .. . ||||.|  || |  ..||   .||. |.|.| . ..|.|.|||.| . .. .  ... . .     .||  .||.|.|| . .
ritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqe..vphegplcdllwsdpedae

cnTFAMNkQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVL
  ..|.   |    .||..  ..| .. ...||.|||.. .||... ||.| .||.||| ||    |  ||... .. .  |...
..gwavs.prgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkif
subfamily_PPP5C_pd Subfamily PPP5C 10-295 4.8e-69 225.8 In-house 16-304 (322) alignment 
Range on Protein: 10-295
Range on HMM: 16-304/322.0
LAKRMIEHLLKWGV-TDAFTDKQIYTILEKAESTLKPLPAMLQVEHP----ITIVGDIHGQLDALIRYFDAVGYPP-KVQFLFLGDYVDRGAKSFEVSLL
..| ....||..    ...  | ...|| .|.. || ||........    .|. ||||||   |.  |.  |.|  .  .|| ||.||||. |.|| |.
itkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsvevilt

LFCYKIRYPHLVHLLRGNHECMKMNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGI-SQNCNSWESFKALKKPNTPltCDEGLQVD
|...|. ||. ..| |||||  .||.|||| .| . |   ..   ...||| |||.  . ...| .|||. |..  . . .. ... . |   .||| |.
llgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqp..peegllve

LMWADPTQDKCNtfaMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHV-SDSYELSFT
|.|.|| . .     .. .| ..| ||    . |||. .|.||.|.||| .||...  . |..|||||| || . .| ||.... .|  .| |.
llwsdpqeanGr...spskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfk
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 25-300 4e-68 222.9 In-house 4-275 (280) alignment 
Range on Protein: 25-300
Range on HMM: 4-275/280.0
DAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHEC
. .| ..| .|.   |. .     . . | || ..|||| | . . | || .|  |. ...||||||||| .  || .|||| ||||   ..||||||| 
nvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhet

MKMNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLtcDEGLQVDLMWADPTQDKCNTFamNKQRAI
  .|..|||| |   | |  .| ..|..|| .|... . .|.||||||.| .    .. . . .|  ||  | || .||.|.|||.     |     |.|
psvnkiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepl..drgllidllwsdptnkgegwf..hsirgi

SVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRPR
| .||.  ...  | | . ||.|||.| |.|....  .. .|||| | || . ||. |.. .    ..||  | | 
symfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
subfamily_PPP2C_pd Subfamily PPP2C 24-298 7.6e-67 218.5 In-house 14-284 (290) alignment 
Range on Protein: 24-298
Range on HMM: 14-284/290.0
TDAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHE
.. ...... .. |||.  |.    . .|. |.|..||.|||.  |.  |   |  |. ..||||||||||  | |   || . |.||.. . .||||||
ckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhe

CMKMNRLYGFYEELTRKRGG-RMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPTqDKcNTFAMNkQR
  .. ..||||.|  || |   .|. . ..|. |||.| | ..|.|.|||.| . .. .  .||.. .     .||  .||.|.||  |. . ...  .|
srqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqe..vphegplcdllwsdpd.dr.ggwgis.pr

AISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLR
     ||..  ..| |. ||.||.|||..  ||.|...... ||.|||| ||    | .||. . |... ||    
gagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfd
subfamily_PPP3C_pd Subfamily PPP3C 13-287 1.3e-66 218.3 In-house 30-310 (452) alignment 
Range on Protein: 13-287
Range on HMM: 30-310/452.0
RMIEHLLKWGVtdaFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYP
 . ||.|| |    ......  |.|.| . ||  ...|.|| |||..||||||   |.. |.  | | . ..||||||||||. |.|. | |.. || ||
vlkehflkegr...leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiayp

HLVHLLRGNHECMKMNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPltCDEGLQVDLMWADPTQDK
. ..|||||||| ..   . | ||.. | . ... .. . |. ||| | . |. ||.|||.| . .| .. | |.. . |     |.  ||.|.||..| 
stlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkep..pasGplcdllWsdPledy

-----CNTFAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFN------KKCVTVFSAPYYCGNDTNCGAIMHVS
      ..|  |. |  |.... |   .||.|  |  |.||||. ..|..   .         .|.|||| |..  .| .|.... 
geekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkye
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 26-299 3.6e-65 213.1 In-house 5-299 (302) alignment 
Range on Protein: 26-299
Range on HMM: 5-299/302.0
AFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDA------------VGYPpKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPH
 .. .......|. ...||   .. ..  |.||||||||| . |.| . |            ...  . .|.||||||||| || |   |.|..|. ||.
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfs.sdkfvflGdyvdrGsksieciclvfalkvlypt

LVHLLRGNHECMKMNRLYGFYEELTR----KRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTcDEGLQVDLMWADPT
   |||||||.  .|  ||| |||      | | ..|.....||  .|| | ||..|||.|||||.. .|.|. | .|.| . .| .. |  ||..|||.
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevt.edslaqdllfadpl

Q-------DKCNTFAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRP
.        .   .| |  |..|||| .  . |. |.|.|.|||||| .  |||.|  .|| .|.|||| |  .  | ||...|    .|| .|||.
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 26-299 6.8e-65 212.2 In-house 6-300 (302) alignment 
Range on Protein: 26-299
Range on HMM: 6-300/302.0
AFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDA------------VGYPpKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPH
 .. .......|. ...||   .. ..  |.||||||||| . |.| . |            ...  . .|.||||||||| || |   |.|..|. ||.
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfs.sdkfvflGdyvdrGsksieciclvfalkvlypt

LVHLLRGNHECMKMNRLYGFYEELTR----KRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTcDEGLQVDLMWADPT
   |||||||.  .|  ||| |||      | | ..|.....||  .|| | ||..|||.|||||.. .|.|. | .|.| . .| .. |  ||..|||.
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevt.edslaqdllfadpl

Q-------DKCNTFAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLRP
.        .   .| |  |..|||| .  . |. |.|.|.|||||| .  |||.|  .|| .|.|||| |  .  | ||...|    .|| .|||.
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
PPP_2 56-251 5.8e-63 205.2 In-house 1-197 (198) alignment 
Range on Protein: 56-251
Range on HMM: 1-197/198.0
ITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMNRLYGFYEELT-RKRGGRMWRQYQNVFN
.|..||.||||| |.. |.  . .|. ..||||||||||.||.|| |||...|..||. |||||||||. |.|..|||..|.. .| | ..... |.||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

ELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPltCDEGLQVDLM----WADPTQDKcnTFAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHE
 |||.| . ...|..|||.|........ |  .....   ..||. .||.    . ||....  ..  |..| ....||..  ...|.|  |.||.||||
lLplaalidekvlvvHGGlseeiklldqikkeerkies..peegklldlleeeklsdpkeke..ellansarGagllfgpdvteelleknklkliiRaHe

V
|
v
subfamily_PPP6C_pd Subfamily PPP6C 31-294 1.7e-62 204.2 In-house 19-278 (290) alignment 
Range on Protein: 31-294
Range on HMM: 19-278/290.0
QIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMNRL
..  . ..    |    ..  |. |.|..||||||.  |   | . |  |. ...||||.||||  |.|   .|.. |..||. . |||||||. .. ..
dlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqv

YGFYEELTRKRG-GRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPtqDKCNTFAMNkQRAISVVFG
||||.| ..| | .  |. . .||. |...| . ...||.|||.| . .  .. . ... .      .|  .||.|.||  .. .|.|.  .|    .||
ygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqe..iphkgafcdlvwsdp..edvetwavs.prgagylfg

QKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSF
.|  ..|..   |.||.|||.. .||... |..| |||.||| ||    |  .|....|. | ..
skvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeerea
PPP_4 56-251 1.8e-62 203.9 In-house 1-196 (197) alignment 
Range on Protein: 56-251
Range on HMM: 1-196/197.0
ITIVGDIHGQLDALIRYFDAV-GYPP-KVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMNRLYGFYEELTRKRGGRMWRQYQNVF
.|.||||||||| |. ..  . | |. . ...|||||||||..|.|| |||...|..||. |.|||||||....|.||||..|...|.| ..... |.||
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

NELPLCARVGQRILCMHGGISQNCNSWESFKALKKPnTPLTCDEGLQVDL-MWADPTqDKCNTfAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEV
. |||.| . ...|..|||.|....|... ...... .. ...|..  || .|.||. .. ..   |..| ....||..  ..||.| .|.||.|.||.
dllplaalidekvlvvhgglsdelesldkierierk.iespleeekrkdlllwsdpr.eaqeg.lansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 56-251 5.2e-60 195.8 In-house 1-198 (199) alignment 
Range on Protein: 56-251
Range on HMM: 1-198/199.0
ITIVGDIHGQLDAL-IRYFDAVGYPP-KVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMNRLYGFYEELTRK-RGGRMWRQYQNV
.|..||.||||| | .. |. .| |. . ...|||||||||..|.|| |||...|..||. |||||||||....|..|||..|  .|  | ....  ..|
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPnTPLTCDEGLQVDL-MWADPTqDKCNTFAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEV
|..|||.| . ...|..|||.|....|.|. ...... .... ..| . || .|.||. |....   |..| ....||..  ..||.| .|.||.|.||.
fdwlPlaalidekvlvvhgglspeiksiellekierk.ieipeekgekadlllwsdpr.daqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 27-298 2.8e-59 193.8 In-house 20-290 (307) alignment 
Range on Protein: 27-298
Range on HMM: 20-290/307.0
FTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMK
.| ...  .. .|.. .    |..... |  .|||.|||.. ||  |  .| ||.  ..| |||||||  |.|. ||||.||| ||. . |||||||  .
ytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiar

MNRLYGFYEELT---RKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPTQDKCNTFAmnKQRA
.|. ||||||      | |  .|  .| .||.||. | .  .|||||||.|      . ..   ||        |.  |..||||     .  |    | 
vnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpir..npfrgivndmlwadpdpsvfewka..ssrg

ISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVLR
  . || . .||  |.||. ||.|||..  .|.  |  .| .|.|||| ||    |.|....| ..  .    . 
sgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafv
subfamily_PPG1_pd Subfamily PPG1 30-297 1e-58 192.0 In-house 17-293 (300) alignment 
Range on Protein: 30-297
Range on HMM: 17-293/300.0
KQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMNR
  .  . .|    |     . ... |.|.|||.|||.  ..  |.  |  |  ..||||||||||  | |   || . |.|||  ..|||||||  .. .
vtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitq

LYGFYEELTRKRGG--RMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPT---------QDKCNTFAM
 |||| |  || ||  |.|. . ..|. | |.| . . | |.|||.| .. | .  | | . .     .||   ||.|.||           |.   . .
vygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfre..vpnegaladllwsdpeennnptldhpdregqhfv

NKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDSYELSFTVL
. ||     .|..    ||..  .  |.|||.. .||.. ||..|  ||.||| ||    |  .|. . .  |  | | 
vsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvy
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 83-300 4.2e-58 190.1 In-house 121-334 (339) alignment 
Range on Protein: 83-300
Range on HMM: 121-334/339.0
QFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMNRLYGFYEELTRKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWES
..||||||||||  |.|| .|| . |. ||  ..|||||||   .|  |||| |.  .   ...  .||.|| .|.|| . . |.|||||||.   |.. 
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

FKALKKPNTplTCDEGLQVDLMWADPtqDKCNTFAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGA
|  .|.|      | |.  || ||||  |  .       |  |.|||   |  ||||| | ...| |.| ..|..|.  .. ||.|||| |||.. |  |
fsvfkrple..ipdvgvltdltwadp..dptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaa

IMHVSDSYELSFTVLRPR
.. .    ..|  |.|| 
vfsidkklkisinvfrpe
subfamily_PPPLV_pd Subfamily PPPLV 35-288 2.2e-48 158.0 In-house 5-277 (290) alignment 
Range on Protein: 35-288
Range on HMM: 5-277/290.0
ILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIrYFDAVGYPP-----KVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLLRGNHECMKMNR
. ..|   |     .|... |. ..||.||.   || ||. | .         ..||||||||||  |.|.   |.  |. ||  |.|||||||   .  
lcdvavdilaaeerllelksptyvlgdlhgnyrdli.yfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

LYGFYEELTRKRGGR---MWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTCD---EGLQVDLMWADPTQDK----------C
 . .. | . | | .   .|  ..|||. ||| | . ....|.|.|| .   .     |...    |  |     | .|..|.|| .|.           
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

NTFAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNdTNCGAIMHVSD
. |. |..|  . ||... |. |||. .|| ..||||| ..|...  . . .||||.  |||  .|  |.. |. 
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvdk
Metallophos Calcineurin-like phosphoesterase 54-251 2.9e-41 134.9 Pfam-A 1-198 (200) alignment 
Range on Protein: 54-251
Range on HMM: 1-198/200.0
HPITIVGDIHGQLDAL----IRYFDAVGYPPKVQFLFLGDYVDRGAKSFEVSLLL--FCYKIRYPHLVHLLRGNHECMKMNRLYGFYEELT---------
..|...||.||.|| |     ..... ....   .|||||.||||  | |.  ||  ...|...|. |.|||||||.. .|  |||..|           
lrilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglang

-------------------------RKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFkalkkpntpltcdeglqvdlmwadptqdkc
                          ..|.. ... ...|..|||.| |...||..||..|   .|..                                
eeeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi..............................

ntfamnkqraISVVFGQKGLDDFLKKLGLSLIVRAHEV
           |. || . |...|.| |. |..|.|. 
..........gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 24-177 6.6e-36 116.8 In-house 30-191 (383) alignment 
Range on Protein: 24-177
Range on HMM: 30-191/383.0
TDAFTDKQIYTILEKAESTLKPLPAMLQVE----HPITIVGDIHGQLDALIRYFDAVGYPP-KVQFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHLVHLL
   .  | . .|| .|. .|| || . .|.    . .|. ||.||.|| |.  .   |.|  .  ..| ||.|||| .| |. |.|... . ||. |.| 
kkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevyln

RGNHECMKMNRLYGFYEELTRKR---GGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNC
||||| . .|  |||  |.. |    | .. |. ..||  |||.. . ..|| .|||||.. 
rGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdkt
subfamily_PPP7C_pd Subfamily PPP7C 199-289 2.9e-18 58.7 In-house 235-324 (383) alignment 
Range on Protein: 199-289
Range on HMM: 235-324/383.0
LQ-VDLMWADPTQDKCNtfAMNKQRAISVVFGQKGLDDFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSDS
 | .|..|.|| ...      |  |   . ||    ...|.| .|.|..|.||  .||..|  .||..|.|||  |  . .| || ......
rqvldilwsdpkakeGc..kpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkd
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 25-79 1.7e-09 30.3 In-house 7-61 (317) alignment 
Range on Protein: 25-79
Range on HMM: 7-61/317.0
DAFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYP
| |..|... .  .|  ..   | .|..| |.||||||||| . |.  .|  |.|
dlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_YNL217W_pd Subfamily YNL217W 55-141 1.4e-08 27.5 In-house 11-88 (235) alignment 
Range on Protein: 55-141
Range on HMM: 11-88/235.0
PITIVGDIHGQLDALIRYFD--AVGYPPKVQFLFLGDYVDRGAKSFEVSLLLfcykirYPHLVHLLRGNHECMKMNRLygfyeELTRKR
 . .|||.||  | ||. .|  ..|  . |  ...|| ...| || ||  ..        . |. ..|||| . . ..     .. .| 
rllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay.....kwvkkp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 26-81 4.6e-07 22.2 In-house 10-65 (339) alignment 
Range on Protein: 26-81
Range on HMM: 10-65/339.0
AFTDKQIYTILEKAESTLKPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPK
 |   ..  .  .|   .   | .|..| || ..||||||.| |.  .|  |.|  
lfcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwpls
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 56-175 6.7e-06 18.2 Pfam-A 3-93 (156) alignment 
Range on Protein: 56-175
Range on HMM: 3-93/156.0
ITIVGDIHGQLDALIRYFDAVgyPPKVQFLFLGDYVDRgaksFEVSLLLfcYKIRyphlVHLLRGNHEcmkmnrlygfY----------Eeltrkrggrm
| |..|.||.|||| .  ...        |..||.|..    .||  ||   .|.    |. .||||.          .                     
iaiiSDlHgnldaleavledi..kevdlilhaGDlvep....eevvell..edip....vlavrGnhD..........eaelpkelavel..........

wrqyqnvFN-------ElplcarvGQRILCMHGGISQ
       ..       |       |.|.| .||   .
.......llaaaaleie.......gdrvllvhgtpls