Gene R13A5.11 in Caenorhabditis elegans

Synonym: CELE_R13A5.11, R13A5.11

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP174_AA protein Get Run
CeleP174_AA_105-412 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 107-413 1.6e-224 736.5 In-house 1-307 (307) alignment 
Range on Protein: 107-413
Range on HMM: 1-307/307.0
VDFLDRHYQVIQAGVHKIQYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTY
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||..|||||.|||||
vdfldrhyqviqagvhkiqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllfty

KICYPENIVLLRGNHEIARVNKKYGFYEECVTSIPKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
kicypenivllrgnheiarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwa

DPDPSVFEWKASSRGSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMIAFVPASENIEKII
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||..||||.||||||||
dpdpsvfewkassrgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpeseniekii

EEKNRVW
|||||||
eeknrvw
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 120-401 1.4e-169 555.5 In-house 2-280 (281) alignment 
Range on Protein: 120-401
Range on HMM: 2-280/281.0
GVHKIQYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRG
..||.||||||.||||.|...|||.|||||.||.|.|||||||.|||||...|.||||.||.|.||.|||||||..|||...||||.||.|...||||||
nihkvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrg

NHEIARVNKKYGFYEECVTsipKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKASS
|||||.|||.||||.||||   |.|||.|||||||||.||||||||...|||||||||.||.||||||.||||||..||.|.|.||||||..|.||||||
nheiasvnkiygfyvecvt...kyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkass

RGSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMIAFVPASEN
|||.||||.||.|||||||.|||||||||...|||.|||||||||.||.|.||.|||||..||||||||||...|.|||||.
rGssftfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpasep
PP2Ac_SM00156 127-397 1.4e-105 345.2 In-house 2-269 (271) alignment 
Range on Protein: 127-397
Range on HMM: 2-269/271.0
TKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIARV
.|||. ... |...|...||.||....|..||||.|||..||.... | |.|||. ||| |||||||..|.|.|.|||..||.|||..||||||||  .|
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NKKYGFYEECVTSIpkcGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKASSRGSGFTF
|| |||.||.   .   |.||.. |...|. ||..||. .||||||||||| |. ||..|.. .. ..| .|.. |.||.||. .. ....|.|| ...|
nkiygfeeevkrky...gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvF

GTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMIAFVP
|........|.. ..||||||... .|| . . .||.||||||.||. ..|...||||...| .... . .
gedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 125-399 6.4e-99 323.7 In-house 23-295 (298) alignment 
Range on Protein: 125-399
Range on HMM: 23-295/298.0
QYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIA
. ..|. |..| .|. ||.. |.||..|.|  | ||.|||..||. .|   | ||.. |.| ||||||| ..|| |.||..||. ||.|..|||||||..
vikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnhece

RVNKKYGFYEECVTSIPKCGeeIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKASSRGSGF
 .|..|||||||     .    ..| ||  || ||. |||...|||||||||. |. ||.||.  .|. ..   ...|.|||||. .| .|...||| ..
ainrvyGfyeeckrrykslr..lyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrGvsv

TFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMIAFVPAS
.||..|. |....| ..|..||||.  |||  ....||.|||||| ||. ..|. .|.|||| | . .  . |..
vfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
subfamily_PPP1C_pd Subfamily PPP1C 122-396 2.2e-98 321.9 In-house 6-277 (282) alignment 
Range on Protein: 122-396
Range on HMM: 6-277/282.0
HKIQYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNH
.... ...| |... .|..|. |. .|.... |  .|||.|||..||...|   | |||. |.| ||||||| .||| |.||..||| ||||. ||||||
kevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnh

EIARVNKKYGFYEECVTsipKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKASSRG
| | .|. ||||.|| .   . . ..|  |. .|| ||..||.. ||||.|||||| |. |...|.  .|.. | .|.. |.||.||| .| .|....||
esasinriyGfydeckr...rysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrG

SGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMIAFV
. ||||..|.......  ..||.||||.  |||   . |.|.|.|||| ||. ..|||.||.|||.| ...  . 
vsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilk
0045823 Metallo-dependent phosphatases 106-412 2.2e-95 313.0 In-house 23-338 (473) alignment 
Range on Protein: 106-412
Range on HMM: 23-338/473.0
FVDFLDRHYQVIQAGVHKIQYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFT
.  .|  ....|.  ..  ....|.. ....||. |...|. |.......||.||.|||. ||.... ..|.|||. .||.||.||||  |||.. ||. 
illglldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlellla

YKICYPENIVLLRGNHEIARVNKKYGFYEECVTSIpkcGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLW
.||.||.|..||||||| . .|  |||..|.  .    ||...  |......||..|.|  |||..|||||| |. ||..|....|.  |  |.. |.||
lkikypgnvfllrGNHElrllnglygfgdetleky...gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllw

ADPDPSVFE-------WKASSRGSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRK------LITIFSAPMYCNFYKNAGCVLKVDETLgIQM
.||..   .       .  | || |..|| .......|. |. ||.|.|... .||..| ..|      .||.|||| ||. ..| ..||..||.| |. 
sdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isf

IAFVPASENIEKIIEEKNRV
| | |..  . . .  .. .
iqfdpsphplilplfldvfl
PPP_3 126-391 2.2e-91 298.6 In-house 2-265 (271) alignment 
Range on Protein: 126-391
Range on HMM: 2-265/271.0
YTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIAR
....|..... ... |...|. ||.|. | .|.||.|||..||...|   |..||| |.| |||||||  |||...||...|| ||....||||||| ..
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

VNKKYGFYEECVtsIPKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKASSRGSGFT
.|| |||..|..    | |....  .|..|. ||..|||  |.|..||||||... ||....  ..|. | .| . | |. ... .   .. |.|| |..
inkvYgFkkevl..kkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagll

FGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQ
||..| ......  ..||||||... .|| .|  .|..|.|||| ||. ..|||..||..|.|  .
FgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtse
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 127-400 3.6e-91 298.5 In-house 25-296 (299) alignment 
Range on Protein: 127-400
Range on HMM: 25-296/299.0
TKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIARV
 ..|. ..   |...| |. .|.....| .|.||.|||. ||. .|   | ||.. ..| |||||||   || |.||. .|| |||.. .||||||   .
keqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpai

NKKYGFYEECVTSIpkCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKASSRGSGFTF
|. |||||||          .|..|| .|. .|.. ||...|||||||||| |. || ||. ..|   |   .  |.|||||| || .|.|  ||  . |
nrvygfyeecnkry..kstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvf

GTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMIAFVPASE
| .|. ||..||...|. ||||.  |||  .. .||.|||||| ||  . |. ...|||| |   .  . |...
gqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpk
0049330 Metallo-dependent phosphatases 121-400 8e-91 297.3 In-house 25-301 (309) alignment 
Range on Protein: 121-400
Range on HMM: 25-301/309.0
VHKIQYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGN
 .  ....||. .....|..|. ||. |.... ..||.||.|||. ||.... ..| |||. .||.||.||||  |||.. ||. .|..||.|..|||||
lklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvfllrGN

HEIARVNKKYGFYEECVTSIpkcGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKASSR
|| . .|  |||..|.. .    |.|.|  |......||. |.|  ||||.|||||| |. ||..|.  .|.. |  |...|.||.||.| . ..  . |
HElrllnglygfgdetlrky...gaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpiregfapnpr

GSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMIAFVPASE
| |..|| .......|..|..||||.|...|.|| .. ..||||.|||| ||. ..|.|.||..||.| |... | |.. 
glgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpl
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 130-399 5e-88 287.9 In-house 10-276 (280) alignment 
Range on Protein: 130-399
Range on HMM: 10-276/280.0
EFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIARVNKK
. ..|| . . |.. ....|..| |  |.||||||..||. .|   . ||.. |.| ||||||| . || |.||..||. ||.|...||||||....|.|
didrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrk

YGFYEECVTSipkCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKASSRGSGFTFGTN
|||..|.        ..... ||  ...||. ||.. .|||||||||. |  ||.|..  .|. ..   . .|.|||||.  |  | ..|||    || |
ygfkdevkrr...yslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifgan

VIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMIAFVPAS
|. |....| ..||.| ||.  |||  ....||.|.|||| |.. ..|. .||.||| | . .  . || 
vvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpal
0053225 Metallo-dependent phosphatases 120-397 2.1e-84 276.4 In-house 16-290 (293) alignment 
Range on Protein: 120-397
Range on HMM: 16-290/293.0
GVHKIQYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRG
 ..  ....||.  ...||..|...|. |.... ...|.||.||.. ||.... ..| |||. .||.||.||||  |||.. ||. .|..||.|.|||||
llllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrG

NHEIARVNKKYGFYEECVTSIPkcGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDpSVFEWKASS
||| . .|  |||..|.. ..   ..|.|  .......||..|||  |||..|||||| |. ||..|.  .|.| |..|...|.|| |||  ...|  | 
NHElmllnglygfgdetlrkyg..aaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.lwsgwlpsy

RGSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMIAFVP
|| |..|| .......|. |..||||.||...|||... ..||.|.|||| |.. ..|.|.||..|| | .... | |
rglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap
PPP_1 127-383 5.5e-84 274.5 In-house 2-263 (264) alignment 
Range on Protein: 127-383
Range on HMM: 2-263/264.0
TKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIARV
..||  ... ........|. |.... .  |.||.||||.||...|   | .||| |.| |||||||  |.|...||...|. ||... ||||||| ..|
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

NKKYGFYEECVtsIPKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDML-------WADPDPSVFEWKASS
.| |||..|..    |...||. ... .|. ||..|||  |||..|||||| |. ||. |.  . .. | .| ..| |       . |.. .   .. | 
tkvygFkkEvl..kkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansi

RGSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLK
|| |..||..|....... ...||||||... .|| .|. ||..|||||. |..  .|.| ..|
RGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 126-398 1.1e-82 270.2 In-house 10-282 (287) alignment 
Range on Protein: 126-398
Range on HMM: 10-282/287.0
YTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIAR
.. ..  .|. ... |.   .||.... | ..|||.|||..||...|   |..|.. |.| |||||||  ||| ..|||..|| ||... |||||||. .
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

VNKKYGFYEECVTsipKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPF--RGIVNDMLWADPDPSVFEWK-ASSRGS
.||.|||.||      | .|...  |.  |..||. | .. .|||||||.|| |  ||.|.  .||  .    .|.. |.|||||.      .    |. 
inklyGfkeelkr...krqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkirai

GFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMIAFVPA
   || ...||..|.|...||.|||..  .||  |  ..|.|.|||| |.    | |.|..|...| .... . | 
svvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpe
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 126-395 3.9e-82 268.9 In-house 8-280 (284) alignment 
Range on Protein: 126-395
Range on HMM: 8-280/284.0
YTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRP------PETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRG
....|. .. | |. .|  ||  ..|. |  .|||.||||.||. .. | | |       |. |.| ||||||| .|.| |.|||.||. .|....||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHEIARVNKKYGFYEECVTsipKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKASS
|||   ||..||||.||.    .  | ..  || .|| .|..|... ||.|||||.|  |  |..| .  .||  |  |.. |. ||||. .|. .| | 
nhesrpvnmqygfyleckk...rysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesp

RGSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMIAF
||.| .||.. ... .|.  ..|..||||.  |||  .. |||.||||||.||  ..|...||.||| | . .  .
rgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvl
subfamily_PPZ_pd Subfamily PPZ 124-389 1.2e-80 264.3 In-house 23-285 (300) alignment 
Range on Protein: 124-389
Range on HMM: 23-285/300.0
IQYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEI
.   ..|  .. ..|. .| .. ||... |.  .|||.|||..||. .|   | || . |.| |||||||  ||| |.||. ||| ||||..||||||| 
vclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhec

ARVNKKYGFYEECVTsipKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKASSRGSG
| | . ||||.||     .|  .||  |   || ||..|..| ||.|.|||||| | ..||.|   .|   |  |..||.||.||  |  ||.   ||  
anvtrvygfydeckr...rcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvs

FTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLG
. .    |. . ...|..|. ||| .  ||| ..  | |.|.|||| ||  . | |.|. | | | 
ycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegll
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 128-397 2.5e-79 259.6 In-house 8-274 (280) alignment 
Range on Protein: 128-397
Range on HMM: 8-274/280.0
KEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIARVN
  |  ..|   ..||  |  |.. . |  |.||.| |..|.  .| |.|| ||   .| |||||||   .| ..|||  || | . | |||||||   ||
gheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvn

KKYGFYEECVTsipKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKASSRGSGFTFG
| |||| ||     | |  .|  || ||| .|.|.||. ..||||||||| |  || .|| |.|.    ||.. |.||.||      |  | ||  . ||
kiygfyvecqy...kygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfg

TNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMIAFVP
  |... || | ..|||||||.  ||| ...||.|||.|| | ||  . || .|. ..  | . .  ..|
kgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlip
subfamily_PPP2C_pd Subfamily PPP2C 125-400 5.1e-79 258.5 In-house 16-288 (290) alignment 
Range on Protein: 125-400
Range on HMM: 16-288/290.0
QYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIA
| ...| .... .|. |.|.|. . ..  |  |.||.|||| ||...| . |. |.| |.| |||||||  |.|.. || . |. |.| |..||||||  
qleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesr

RVNKKYGFYEECVTSIpkCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDpSVFEWKASSRGSGF
.. . ||||.||.        ..| .|   |. ||..||.  .|.|.||||||....||..|.  .    |  | . |.||.|||     |  | ||.|.
qitqvygfydeclrky..gnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagy

TFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMIAFVPASE
||| .. ..  |. |..||.||||....|| ..  |...|||||| ||.   | ...|..|..|  ... | ||..
tfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpapr
subfamily_PPP4C_pd Subfamily PPP4C 126-395 4.9e-78 255.3 In-house 16-282 (288) alignment 
Range on Protein: 126-395
Range on HMM: 16-282/288.0
YTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIAR
 ..|| ...  .|. |.  |  .  .| | .| ||.||||.||...| . |  ||| |.| ||.||||..|.|...|| ..|. ||..|.|.|||||  .
ikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrq

VNKKYGFYEECVTSIpkCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVfEWKASSRGSGFT
. . ||||.||.        ..| .  . |. |...|.|  ||.|.|||||| .. |||.|   . .  |  |.. |.||.||.     | .| ||.|. 
itqvygfydeclrky..gsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae.gwavsprgagyl

FGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMIAF
||..|... ... ..|||.||||.  .|| .   .|..|..||| ||    |   .|..||.|  ..  |
fgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkif
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 130-393 2.2e-76 250.0 In-house 27-290 (297) alignment 
Range on Protein: 130-393
Range on HMM: 27-290/297.0
EFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIARVNKK
   ...  |  .| ..|..|... |  |.||.|||| ||. .|   | || . |.| ||||||| .|.| |.||..||. .| |..|||||||   ||| 
rvlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkv

YGFYEECVTSIPKCgeEIWALFQRCFNNLPISALIATKILCMHGGLSPALT---CLDELRNHPKPIrNPFRGIVNDMLWADPDPSVFEWKASSRGSGFTF
|||||||          ..| ||  || ||.. ||||||||||||||| ||   .|| ||.  ..  .   ..| |.|||||   .  .    ||.|  |
ygfyeecqkryqsv..rmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierst.egkerlvadllwadpisglsgfmenqrgagcgf

GTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMI
| . . ..|  . ..|. ||||.  ||| ...||||.|||||| ||  . |. ... .|| |   . 
grdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfe
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 182-399 2.4e-74 243.4 In-house 102-316 (317) alignment 
Range on Protein: 182-399
Range on HMM: 102-316/317.0
VYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIARVNKKYGFYEECVTsipKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTC
 |.| ||||||| .|.| ..|||..|. ||....|||||||   ||..||||.|.     .  ....  ||  || ||..|... ||||||||.|  |. 
kylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkk...rysaalyeafqlafnvlplcavvnkkilcmhGGiseelld

LDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKASSRGSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCV
|..| .  .|.  |  |.. |. |||||..|  .| |.||.|. ||.. ... .|.| ..|..||||.  |||  ...|||.||||||.||   .|...|
lkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav

LKVDETLGIQMIAFVPAS
|.||. | | .  . | |
lsvdkklkisinvlrpes
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 126-397 4.7e-74 242.0 In-house 16-288 (290) alignment 
Range on Protein: 126-397
Range on HMM: 16-288/290.0
YTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIAR
.. ..  ... ... |.    ||...  | |.|||.|||...|...|  .|.||.  ..| |||||||  |||  .||| ||| |.... |||||||. .
fsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrk

VNKKYGFYEECVTsipKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPI--RNPFRGIVNDMLWADPDP---SVFEWKaSSR
||. |||.|| .    | | ..|  .|  |..|.. | .. ||||||||.|. .   . |.   ||    .  .|.. |.|||||.      .. .   |
vnrlygfkeelar...krgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialn.kqr

GSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMIAFVP
.    || ...||..|.|...||.|||..  .|.  |  .||.|.|||| |.    | |....| |.| ...... |
aisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkp
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 128-397 2e-73 240.3 In-house 5-273 (284) alignment 
Range on Protein: 128-397
Range on HMM: 5-273/284.0
KEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIARVN
 |. | ....| .||  .  |.... |  ..||.|||| ||. .|   | |  . |.| |||||||   || |.|||.||. .|. ...|||||| . .|
pedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslin

KKYGFYEECVTSIPKCgeEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFR-GIVNDMLWADPDPSVFEWKASSRGSGFTF
|.|||||||     |    ..  |.  | ..|..||.  .|||||||.|  |  . .||   .|. ||    .  |.||.||      |.  |||  . |
kiygfyeecqrrynkp..svyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvf

GTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMIAFVP
|.. .  .  || ..|..||||.  ||| ... |.|.||||||.||  . || .|. |.. |   .. . |
gsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrp
subfamily_PPP6C_pd Subfamily PPP6C 125-396 1.3e-71 234.1 In-house 13-282 (290) alignment 
Range on Protein: 125-396
Range on HMM: 13-282/290.0
QY-TKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEI
.| ........    . ... | ... .  |  |.||.|||| || ..|   |. |.| ||| ||.||||  ||| . .|.| |. ||..|.||||||| 
kylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhes

ARVNKKYGFYEECVTSIPKCgeEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDpSVFEWKASSRGSG
 .. . ||||.||..   ..  . |  . . |. |.|.|.|  ..||.|||||| .. ||..|   . .  |..| . |..|.||.  | .|. |.||.|
rqitqvygfydeclnkygna..nawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpe.dvetwavsprgag

FTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMIAFV
. ||..| .. ..   ..||.||||.  .|.      ||.|..||| ||    |  ..|.....   ..  | 
ylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 123-393 4e-71 232.7 In-house 3-295 (302) alignment 
Range on Protein: 123-393
Range on HMM: 3-295/302.0
KIQYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPP-----------ETVYVFTGDYVDRGMMSLECIMLLFTYKICYP
| .|.|.|.  .| .    .. ||.|..| ||  .|||.||||.||. ..                  .  .|| |||||||  |.||| |.|..|..||
kkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyp

ENIVLLRGNHEIARVNKKYGFYEECVTSI-PKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFR-GIVNDMLWADPD
.| .|||||||   .|  ||| || .. . .| | |||  |. .|  .|..||.  ||||.|||.|| |..|.....  .|. .     . .|.|.||| 
tnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpl

PS--------VFEW-KASSRGSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMI
            .. |   ||  ..|    . ||||||...||.|||||   |.   . .||.|||||| | |   | | |||||    ....
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsis
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 123-392 7.8e-71 231.7 In-house 4-295 (302) alignment 
Range on Protein: 123-392
Range on HMM: 4-295/302.0
KIQYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPP-----------ETVYVFTGDYVDRGMMSLECIMLLFTYKICYP
| .|.|.|.  .| .    .. ||.|..| ||  .|||.||||.||. ..                  .  .|| |||||||  |.||| |.|..|..||
kkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyp

ENIVLLRGNHEIARVNKKYGFYEECVTSI-PKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFR-GIVNDMLWADPD
.| .|||||||   .|  ||| || .. . .| | |||  |. .|  .|..||.  ||||.|||.|| |..|.....  .|. .     . .|.|.||| 
tnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpl

PS--------VFEW-KASSRGSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQM
            .. |   ||  ..|    . ||||||...||.|||||   |.   . .||.|||||| | |   | | |||||    ...
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsi
subfamily_PPP5C_pd Subfamily PPP5C 106-390 8.6e-69 225.0 In-house 20-301 (322) alignment 
Range on Protein: 106-390
Range on HMM: 20-301/322.0
FVDFLDRHYQViQAGVHKiqytkEEFENVIYEAQTIFSSEKALVDIDPP----CVVVGDLHGQFNDLINMFILLGRPP-ETVYVFTGDYVDRGMMSLECI
||. | ....  |  .||         ... ||....... .||.|. .      | ||.|||| ||.|.| | |.|  |  |.| ||.|||| .|.|.|
fvkellelfkk.qkklhk.....kyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsvevi

MLLFTYKICYPENIVLLRGNHEIARVNKKYGFYEECVTsipKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSP-ALTCLDELRNHPKPIRNPFRGI
..|...|. ||... | |||||  ..|| ||| .|. .   |  |..  ||.. || ||.. .|  |.| .||||       ||.||.  .  ..|  |.
ltllgfkllyPnhfflsrGnhesdnmnklyGfegevka...kytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegl

VNDMLWADPDPSVFEwKASSRGSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKV-DETLGI
. ..||.||...    ..|.|| |..|| .| .  .|  ..|||||.|..  .|| |    ||||.|||| ||.   | |..... .. | .
lvellwsdpqeanGr.spskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlkl
subfamily_PPP3C_pd Subfamily PPP3C 121-387 9.4e-68 222.0 In-house 36-312 (452) alignment 
Range on Protein: 121-387
Range on HMM: 36-312/452.0
VHKIQYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGN
... . ..|.  ..| || .....||.|.... | .|.||.|||| ||...| . | | .| |.| |||||||. |.||.. |.. ||.||... |||||
lkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGn

HEIARVNKKYGFYEECVTsipKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWK----
||   . . . | ||| .   | .||..  . ..|..||..||.  . ||.|||||| .. ||....  .    | .| . |.||.||     | |    
hecrhlteyftfkeecki...kyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteek

---ASSRGSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSG------RKLITIFSAPMYCNFYKNAGCVLKVDET
    | ||  . .. . . .  ..  .  |||||.   .|| .           |||.|||| |.. |.| . |||... 
fvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn
PPP_2 156-349 1.2e-67 220.4 In-house 2-197 (198) alignment 
Range on Protein: 156-349
Range on HMM: 2-197/198.0
VVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIARVNKKYGFYEECVtsIPKCGEEIWALFQRCF
.|.||||||..||...|   ...||. |.| |||||||  |||...||...|. ||....||||||| ..||| |||..|..    | |....  .|..|
tvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevl..kkkggkkvykklqevf

NNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDML----WADPDPSVFEWKASSRGSGFTFGTNVIDDVCKRLGVELIIRAHQM
. ||..|||  |.|..|||||.... ||. ... ..|. | .| ..| |    . ||. .   .. |.|| |..||..|.......  ..||||||..
elLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_PPG1_pd Subfamily PPG1 133-400 2.6e-66 216.9 In-house 21-298 (300) alignment 
Range on Protein: 133-400
Range on HMM: 21-298/300.0
NVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIARVNKKYGF
....  . .. .|  ...|  |  ||||.|||| |....| . |. |.| |.| |||||||. |.| |.|| . |. ||  | |||||||  .. . |||
eltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygf

YEECVTSIPkCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPD---------PSV--FEWKASSRG
| ||.         .|  .   |. | ..|.|  .| |.||||||.  ..|...   .    |  | . |.||.||.         |     ... | ||
yteclrkyg.gnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsqrg

SGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMIAFVPASE
.|...| .|.    .   .. ||||||.| .|| .|   || |..||| ||.   |   .|.. | .   . ..  | |
agysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeape
PPP_4 156-349 5.7e-64 208.8 In-house 2-196 (197) alignment 
Range on Protein: 156-349
Range on HMM: 2-196/197.0
VVVGDLHGQFNDLINMFILLG-RPP-ETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIARVNKKYGFYEECVTSipkCGEEIWALFQR
.||||.|||..||.. .. .| .|. |. ||| |||||||  |||...||. .|. ||...|||||||| . .|. |||..|...     |.||.  .|.
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek...hgkeilkklqd

CFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNP-FRGIVNDM-LWADPDPSVFEWKASSRGSGFTFGTNVIDDVCKRLGVELIIRAHQM
.|. ||..|||. |.|..|||||. |. ||..... ..|. |  ..  .|. ||.|| ..   .. | || |..|| .|....... ...||||.|..
vfdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 156-349 2.8e-61 200.0 In-house 2-198 (199) alignment 
Range on Protein: 156-349
Range on HMM: 2-198/199.0
VVVGDLHGQFNDLINMFILLG-RPP-ETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIARVNKKYGFYEECVTSIpkCGEEIWALFQR
.|.||||||..||.  ..  | .|. |. |||.|||||||  |||...||. .|. ||....|||||||   .|. |||..|...     |..|.  ...
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlsky..hgkkiykilsd

CFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNP-FRGIVNDM-LWADPDPSVFE-WKASSRGSGFTFGTNVIDDVCKRLGVELIIRAHQM
.|. ||..|||. |.|..|||||| .  ...|..  ..|. |  .|  .|. ||.|| ... . .  | || |..|| .|....... ...||||.|..
vfdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 147-397 5.7e-61 199.5 In-house 1-255 (263) alignment 
Range on Protein: 147-397
Range on HMM: 1-255/263.0
ALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIARVNKKYGFYEECVTSIPK--CG
||.... |  ..|| |||.|||. .|   |   .| |.| |||||||  ||| |||||. |.. | .. |||||||.  .||.|||. |    . .    
allelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevy

EEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNP-FRGIVNDMLWADPDPSVFEWKA-SSRGSGFTFGTNVIDDVCKRLGVEL
| ..  |.. |. .|. |... .|||||||.|| |  ||..|  | |.     . .  |.|||||.     ..    |     || . .||.|||| ..|
esvynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidl

IIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMIAFVP
|.||||.   || ... |.|||.|||  |     |  .|. |.. | . .. . |
ivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 182-400 3.2e-59 193.7 In-house 121-336 (339) alignment 
Range on Protein: 182-400
Range on HMM: 121-336/339.0
VYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIARVNKKYGFYEECVTsipKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTC
 |.| ||||||| .|.| ..|| . |..||. | |||||||   ||  |||| |      .   ...  ||  || .|. |.|   |.|||||.|  || 
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevny...rydaqlyecfqnmfnvfpfcavinntimcmhggisehlts

LDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKASSRGSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCV
....    .|.  |  |.. |. ||||||.   .| |.||. | ||   .  . |.| ....|| ||.  ||| .. ||.|.|||||| ||    |. .|
fnqfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaav

LKVDETLGIQMIAFVPASE
. .|. | | .  | | | 
fsidkklkisinvfrpesr
subfamily_PPPLV_pd Subfamily PPPLV 136-386 1.9e-49 161.5 In-house 7-278 (290) alignment 
Range on Protein: 136-386
Range on HMM: 7-278/290.0
YEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRPPE----TVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIARVNKKYG
  |  |. .|. |.... |. |.|||||...||| .   | |       . ..| ||||||| .|.| |  |.. |. ||  ..|||||||.  | ... 
dvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesie

FYEECVTSIPKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALT---CLDELRNHPKPIRNPFRG--IVNDMLWADPDP-------------SVF
.. |.     .  ||.|  |. .|. ||..| |  |..|.|.|.  |      .  ... .. ....  |  .  |.||.||.                |
ykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGf

EWKaSSRGSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDE
    ..|| |  |... ..   || ... ..|||..   |. .  . .|.|.||.  ||    .| ..|   .
vdn.drrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalilvdkk
Metallophos Calcineurin-like phosphoesterase 156-349 6.3e-38 124.0 Pfam-A 4-198 (200) alignment 
Range on Protein: 156-349
Range on HMM: 4-198/200.0
VVVGDLHGQFNDL----INMFILLGRPPETVYVFTGDYVDRGMMSLECIMLL--FTYKICYPENIVLLRGNHEIARVNKKYGFYEECVT-----------
.|.|||||...||      .. . .... ....|.||.||||  |.|...||  . .|. .| ...|||||||   .|. |||..|.             
lvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangeee

--------------------SIPKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPAL-TCLDElrnhpkpirnpfrgivndmlwadpdpsvfewka
                    . |. | .... ....|..||. ||.  |||..||.||. . ...|.                                 
yenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi.................................

ssrgSGFTFGTNVIDDVCKRLGVELIIRAHQM
     .. || .. .. ... || |..|.|. 
....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 133-283 1.5e-36 118.9 In-house 40-194 (383) alignment 
Range on Protein: 133-283
Range on HMM: 40-194/383.0
NVIYEAQTIFSSEKALVDIDP----PCVVVGDLHGQFNDLINMFILLGRP-PETVYVFTGDYVDRGMMSLECIMLLFTYKICYPENIVLLRGNHEIARVN
....||. .. . . .  .         | |||||...||. ..   | | .|  ||| ||.||||. |.| ...|... . ||... | |||||   .|
lilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhiln

KKYGFYEECVTSIPKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPAlTCLD
 .|||  |  .  .. |..| .|..  |  ||...||  ||| .|||.|   | |.
lryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdk.tdle
subfamily_PPP7C_pd Subfamily PPP7C 300-403 6e-17 54.4 In-house 237-340 (383) alignment 
Range on Protein: 300-403
Range on HMM: 237-340/383.0
VNDMLWADPDPSVFEWKASSRGSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNAGCVLKVDETLGIQMIAFVPAS
| |.||.||      .  . ||.|  ||..| ... .. ...|.||.|.  ..|| .   .|..|||||  | .   | |  .|. ..|  ... .. ..
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqask

ENIE
.. .
atkk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 126-178 6.1e-10 31.8 In-house 9-61 (317) alignment 
Range on Protein: 126-178
Range on HMM: 9-61/317.0
YTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRP
....|. .. | |. .| .|.  .... |  .|||.||||.||. .. | | |
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_YNL217W_pd Subfamily YNL217W 155-277 1.7e-08 27.3 In-house 12-138 (235) alignment 
Range on Protein: 155-277
Range on HMM: 12-138/235.0
CVVVGDLHGQFNDLINMFI--LLGRPPETVYVFTGDYVDRGMMSLECIMLLftykicYPENIVLLRGNHEIARVN-----KKYGFYEEC--VTSIPKCGE
 .|||| || ...||...     |. .. . |. || ...|  |.| . ..        ..   ..||||.. .      ||   .|.    . .     
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsfles

EIWALFQRCFNNLPIS-ALIATKILCMHGGLSP
..     .   .|. |  . ....| .|.||.|
klskadmeyarelgfsldipsdellvvhaGlvp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 129-178 1.3e-06 20.8 In-house 14-63 (339) alignment 
Range on Protein: 129-178
Range on HMM: 14-63/339.0
EEFENVIYEAQTIFSSEKALVDIDPPCVVVGDLHGQFNDLINMFILLGRP
 |. .. . |. .  ||  .. .. | .|.||.||||.||. |. . | |
aelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwp