Gene T16G12.7 in Caenorhabditis elegans

Synonym: CELE_W03D8.2, W03D8.2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP184_AA protein Get Run
CeleP184_AA_15-315 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 18-315 4.3e-137 449.0 In-house 2-295 (298) alignment 
Range on Protein: 18-315
Range on HMM: 2-295/298.0
NVDDIIVKILNIGSGGNNFEAIMSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLF
.||......|...  ...   ..... . .|.. ||..| || ...|..||.|.|||.||||||.|||||..|||| .||||||||||||.|.||| .|.
evdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivll

LAYKVKFPGNFFMLRGNHECGSINRVYGFLDEVQRKYGAkggTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVlEVANPSVEI
||||||.| |||.||||||| .||||||| .|..|.|     ..... ||  |. .|.|||..|||||||||.||....|.|||.|.||. .  ..|..|
laykvkypnnffllrGnheceainrvyGfyeeckrryks...lrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpf.dskeeslai

DILWSDPDSTVDDFVDSTRGVGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMRPSI
|.||.||...| .. ...|||..|||....  ...|||.|||.||||||||||||| .|.||||||||||||.|||.||.|.||..|..||....|. 
dllwadpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 18-315 5.9e-132 432.4 In-house 2-295 (299) alignment 
Range on Protein: 18-315
Range on HMM: 2-295/299.0
NVDDIIVKILNIGSGGNNFEAIMSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLF
.||....|.||.|  ....   . .. |..| . ||.||..| ..||.|||...|||.||||||.||.||. |||| ||.||||||||||.| ||. .|.
dvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitll

LAYKVKFPGNFFMLRGNHECGSINRVYGFLDEVQRKYGAkggTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVlEVANPSVEI
|..|.|.| .|||||||||| .||||||| .|....| .   | .|  || .||.||.| |...||||||||.| ....|.|||.|.||  .  |||..|
lcfkikyperffmlrgnhecpainrvygfyeecnkryks...trlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpq.dppnpslgi

DILWSDPDSTVDDFVDSTRGVGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMRPSI
|.||.||| .| |.   .|||  ||| . .. ....||.||||||||||||||||| .|.||||||||||||.|||.||.|.||.|| |.|....|. 
dllwadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptp
subfamily_PPP1C_pd Subfamily PPP1C 35-314 7.2e-129 421.9 In-house 5-279 (282) alignment 
Range on Protein: 35-314
Range on HMM: 5-279/282.0
NFEAIMSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGN
. |. ...... .||..|......| ..|||||||||.||.||||.|.||||...|.||  ||||||||||||.||||. .|.||||.|.| |.|.||||
gkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGn

HECGSINRVYGFLDEVQRKYGAKggttMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVlEVANPSVEIDILWSDPDSTVDDFVDS
||. ||||.||| ||..|.|..|    .|..|. .|...|..|||. .|||.|||.|.....|.|.|..|||. ||.. .. .|.||||||..| .. ..
hesasinriyGfydeckrrysik....lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPl.evpekgllcdllWsdpdkevlgwsen

TRGVGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMRPS
.|||  .||.........| |.||. ||||||.||||||....|||.||||.||||||||.|...||..|..||||..|.
drGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpa
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 43-315 3.8e-114 373.6 In-house 9-276 (280) alignment 
Range on Protein: 43-315
Range on HMM: 9-276/280.0
KTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHECGSINR
  . ....  |.... | .|.|..|||..|||.||||.|.||||.| .|||  ||||||||||||.| ||| .| |||||..| ||..||||||. ||||
adidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinr

VYGFLDEVQRKYGakggTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVlEVANPSVEIDILWSDPDSTVDDFVDSTRGVGQVF
 ||| |||.|.|       ..| ||  .  .| .|||||||||||||.|...  |..|..|.||  .  . ... |.||.||.. |  . ...||| ..|
kygfkdevkrrys....lalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpf.dsedeclamdllwadpenkvtgwaensrgvsvif

GAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMRPSI
||. .  ...|||.||.|| ||||||||||| .|.|||.||||.|.|||||.||.. ||..|  ||....|..
ganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpal
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 44-314 1.2e-110 362.4 In-house 7-274 (284) alignment 
Range on Protein: 44-314
Range on HMM: 7-274/284.0
TLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHECGSINRV
 . .||  | ..| ||  ..| ..|..||||.|||.||.|||||. |||   ||||||||||||.. ||   |..|||| ||  ||||||||||  ||..
dvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinki

YGFLDEVQRKYGAkggTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVLEVANPSVEIDILWSDPDSTVDDFVDSTRGVGQVFG
||| .|.||.|      ...  |.  |. || ||||  ||||||||.|| ..|. ||| ..||. .    .. ||||||||      .   .|||  |||
ygfyeecqrrynk...psvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfg

AKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMRPS
. ||  ....|..||| ||||||||||||| |.||||||||| |||.||||||.| |.||| ||| ..|| 
sdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrpr
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 19-314 6.2e-107 350.3 In-house 2-295 (297) alignment 
Range on Protein: 19-314
Range on HMM: 2-295/297.0
VDDIIVKILNIGSGGNNFEAIMSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFL
||.||. .|   .  . .  ..... .. ||| | ||| .| .|.|..||.|.|||.|||. |.|||| |||.||  ||||||||||||. |.|   |.|
vdsiiidvlsasthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlll

AYKVKFPGNFFMLRGNHECGSINRVYGFLDEVQRKYGAkggTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMN---NLNQLRNLQRPVlEvANPSV
|||||||||.|.|||||||  .|.|||| .|.|..| .     |. .||  | ..| | |.. .|||||||.|  .     |. ||...|.  |  . ..
aykvkfpgnlfllrgnhecefvnkvygfyeecqkryqs...vrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierst.e.gkerl

EIDILWSDPDSTVDDFVDSTRGVGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMRPS
  |.||.|| | .  |..  || |  ||  |.  .  ....|||.|||||||||||||  ..||||||||||||.|||.||.| .|..| |||.|.||.
vadllwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
PP2Ac_SM00156 40-313 7.3e-106 346.1 In-house 1-269 (271) alignment 
Range on Protein: 40-313
Range on HMM: 1-269/271.0
MSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHECGS
.|.. ...||...|...... ...|..||| ..||.|||..|.|||....|.||  .|.|||||||||.||.|| .|..|.|...| ....||||||. |
lskeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsss

INRVYGFLDEVQRKYgakgGTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRpVLEVANPSVEIDILWSDPDSTVDDFVDSTRGVG
.|..||| .||.|||    |. ....|. .|...|..|||. .|||||||.|.....|...|.|.| | | .. .. ||.|||||......|  |.||..
vnkiygfeeevkrky....gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkr.vkekpeegllidllwsdpeqkekgfqpskrgls

QVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMRP
 |||..|.. ...|....|. |||.||..||||| .|.||||||||.||.||.|.||...|.|||..|.. ...
vvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 37-314 2.9e-101 331.7 In-house 5-283 (284) alignment 
Range on Protein: 37-314
Range on HMM: 5-283/284.0
EAIMSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFP------PLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFM
. ....| |. |   |...| |.   ||.||||||.||.|||. |.| |.|  |.|         .|||||||||||  |.||  |..|||...| . |.
qkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfl

LRGNHECGSINRVYGFLDEVQRKYGakggTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVlEVANPSVEIDILWSDPDSTVDD
||||||   .|. |||  | ...|     ......||..|  || .|.|| .|.|||||||. . .|.|| .|.||. ....  |  |. |.||...|. 
lrgnhesrpvnmqygfyleckkrys....ealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpi.dipdigviadltwadpeaeveg

FVDSTRGVGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMRPS
. .| || |.||||||.  ...| ..||| ||||||.|||||| ...|||||||| |||..||.||..|||..| .||....| 
ykesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkpd
subfamily_PPZ_pd Subfamily PPZ 18-313 3.5e-98 321.8 In-house 2-293 (300) alignment 
Range on Protein: 18-313
Range on HMM: 2-293/300.0
NVDDIIVKILNIGSGGNNFEAI-MSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACL
..|.|| |.|. |   .  . . . .. .. .   |...|. | |.|||  .||| |||||||.|.|||| . ||||  ||||||||||||.||||   |
dideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletill

FLAYKVKFPGNFFMLRGNHECGSINRVYGFLDEVQRKYGAKggttMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVlEVANPSVE
.|.||.|.| |||.|||||||  . ||||| ||..|.   |    .|. |   |  .| .|.|.|.|.|.|||.|  .|.....| . ||  .| .  . 
llcykikypenffllrgnhecanvtrvygfydeckrrcnik....iwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrpt.dvpdfgli

IDILWSDPDSTVDDFVDSTRGVGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMRP
 |.|||||  . ... |  |||  ..   |.  ..||. .|||.||| ||.|||||||.. |||.|||| |||||||  |.|.| . | |||... |
ndllwsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
0045823 Metallo-dependent phosphatases 37-315 4.1e-96 315.4 In-house 40-325 (473) alignment 
Range on Protein: 37-315
Range on HMM: 40-325/473.0
EAIMSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHE
| ... ..|..||| ||....|.  .|||.... ..||.|||. | |||... ||||  ...||||.|||| .|||| .| ||.|.|.|||.|.||||||
egllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHE

CGSINRVYGFLDEVQRKYGAKggttMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVlEVANPSVEIDILWSDPDSTVDD------
.  .| .|||.||. .|||..    ... |. .....|..|.. |.||..|||.|  ...|.|.|...||  |. . ..  |.|||||...  |      
lrllnglygfgdetlekyged....lyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpl.eipddgllldllwsdPweddgdgllrlr

-FVDSTRGVGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKR------LVTIFSAPHYCGEFDNAAAMMNVDKNLtCSFQIMRPSI
 |. | ||.| .||..|.  ...| ..||. |.|..|..|||......      ..|.||||.|||...| ||.. .|..| .||....|| 
ffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsp
PPP_3 40-312 1.6e-94 308.9 In-house 2-270 (271) alignment 
Range on Protein: 40-312
Range on HMM: 2-270/271.0
MSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHECGS
.|...|..|.. .|....|.  ..|..|||..|||.|||. |.|.||. ||..|  .|||||||||||..|||| .|.||.|.|.| ....||||||. .
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INRVYGFLDEVQRKYGakgGTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVlEVANPSVEIDILWSDPDSTVDDFVDSTRGVG
||.|||| .||..|.|   |..... .| .|...| .||.....|..|||.|.....|.|...|.|.  || . .  .| |.|..... . .  |.||.|
inkvYgFkkevlkkkg...gkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerki.evpeegklldlllssdpekeeglenskrGag

QVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMR
 .||... . ...| ...|..|||.....|||.......||.||||.||....||.|.......||..|....
llFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 40-314 3.8e-94 307.8 In-house 10-282 (287) alignment 
Range on Protein: 40-314
Range on HMM: 10-282/287.0
MSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHECGS
.|.| ....|. .....    |.||.|||..|.||.|||. |.||.|.  | .| |.||||||||||| .||||. |....|...| .  .||||||.  
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

INRVYGFLDEVQRKYGakggTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVLEVAN-PSVEIDILWSDPDSTVDDF-VDSTRG
||..||| .|..||..      ... |.  |...|  | || ||||||||||.... |..|. |..|  ..|    . .|.||.||.   . | ..  |.
inklyGfkeelkrkrq....erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkira

VGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMRPS
. .||| | .  ...|||.||. |||.|...||.|. .|||||.||||.|.||  | .|.. |.| |  ||  ..| 
isvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpe
0049330 Metallo-dependent phosphatases 16-314 4.7e-94 307.9 In-house 6-299 (309) alignment 
Range on Protein: 16-314
Range on HMM: 6-299/309.0
DLNVDDIIVKILNIGSGGNNFEAIMSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVAC
.| ....|...|..  .   .. ..| ..|. ||. ||....... .|||.... ..||.|||. | |||... ||||  ...||||.|||| .|||| .
pllllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevll

LFLAYKVKFPGNFFMLRGNHECGSINRVYGFLDEVQRKYGAKggttMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVlEVANPSV
| ||.|...|.|.|.||||||.  .|..|||.||..|||||.    .|. |. .....|..|.. |.|||.|||.|  ...|.|.|.|.||. |. . ..
lllalkllypdnvfllrGNHElrllnglygfgdetlrkygae....lweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpl.eipldgl

EIDILWSDPDSTVDDFVDSTRGVGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMRPS
  |.|||||. ....|....||.| |||. |.  ...|...||. |.|..|..||..| ...|.|.||||.|||...|..|.. .|..|..||....|.
lcdllwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepv
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 96-314 1.4e-90 296.7 In-house 102-315 (317) alignment 
Range on Protein: 96-314
Range on HMM: 102-315/317.0
NYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHECGSINRVYGFLDEVQRKYGAkggtTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMN
.|||||||||||  |.||  |..|.|...| . |.||||||  ..|. |||  ||...| |    .....||  |  .|..|.|. .|||||||||. . 
kylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysa....alyeafqlafnvlplcavvnkkilcmhGGiseell

NLNQLRNLQRPVlEVANPSVEIDILWSDPDSTVDDFVDSTRGVGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAA
.|.|| .|.||. ....  |  |. |.|||..|. . .|.|| |.||||||. . ..|||.||| ||||||.||||||....|||||||| |||..||.|
dlkqldklkrpl.dipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldnia

AMMNVDKNLTCSFQIMRPS
|...|||.|..|....||.
avlsvdkklkisinvlrpe
PPP_1 41-300 2.7e-88 288.7 In-house 2-264 (264) alignment 
Range on Protein: 41-300
Range on HMM: 2-264/264.0
SQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHECGSI
....|..|.. .|....|.  .||.......|||.|||. |.|.||  ||..|  ||||||||||||..|.|. .|.||.|.|.| ..|.||||||. ..
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

NRVYGFLDEVQrkyGAKGGTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVLEVANPSVEI------DILWSDPDSTVDDFVDS
..|||| .||.     |....... .. .|...| .||. ..||..|||.|. .. |.| |...|    ...  ..       |||.||.... . . .|
tkvygFkkEvl...kkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavans

TRGVGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNV
.||.| .||... . ...| ...|..|||.|...||||......||||||. |. |..|..|....
iRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 39-314 1.2e-87 286.8 In-house 6-277 (281) alignment 
Range on Protein: 39-314
Range on HMM: 6-277/281.0
I-MSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHEC
. .... .....  .. .|... |. |...|... ||.|.|. |. |||.  | .|   ..|||||||||.|||||  |....|.... . ..|||||| 
vqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhei

GSINRVYGFLDEVQRkygaKGGTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVLEVaNPSVEIDILWSDPDSTVDDFVDSTRG
 |.|..|||  | .     | |. .|  || ||  .| .||.. |.||||||.|  . .|..|||  .|. .. .  . ||.||.|||. | ..  |.||
asvnkiygfyvecvt....kyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnl.drGlviDllwadpdnkveewkassrG

VGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMRPS
.. .|| . .  .  .|.|.|. ||||||||||| .. ..|.|.||.| ||  . ||||.. ||..|  |.. . |.
ssftfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpa
0053225 Metallo-dependent phosphatases 32-314 9.6e-86 280.8 In-house 14-291 (293) alignment 
Range on Protein: 32-314
Range on HMM: 14-291/293.0
GGNNFEAIMSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFML
.   .  ..| ..|. ||. ||....|.. .|||.... ..||.||.. | |.|... ||||  ...||||.|||| .|||| .|.||.|...|.|...|
elllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvll

RGNHECGSINRVYGFLDEVQRKYGakgGTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVLEVANpSVEIDILWSDPDsTVDDF
|||||.  .| .||| ||. ||||   .  .|. .. .....|..||. |.||..|||.|  ...|.|.|...||  .  . ..  |.||||||  ....
rGNHElmllnglygfgdetlrkyg...aaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriple.gllldllwsdpd.lwsgw

VDSTRGVGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMRPS
. | ||.| |||. |.  ...| ..||. |.||||.|||... ...|||.||||.|.|...|..|.. .|..|...|....|.
lpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 40-314 1.1e-82 270.3 In-house 16-289 (290) alignment 
Range on Protein: 40-314
Range on HMM: 16-289/290.0
MSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHECGS
.|.| ....|. .....    |.||.|||. | ||.|||  ..|| ||  |.|| |..|||||||||| .||||. |.. ||.... .  .||||||.  
fsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrk

INRVYGFLDEVQRKYGAKggttMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVLEV-ANPSVEIDILWSDPDSTVDDF--VDSTR
.||.||| .|. || |..    .|. .|  || ..  | |. .|||||||||....  . |. |..|  ..  .  . .|.||.||.   ||   ..  |
vnrlygfkeelarkrgsr....lwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqr

GVGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMRPS
..  ||| |.|  ...|| ..|. |||.| ..|..|  .|.|||.||||.|.|.  |  |...| . |  |. ...| 
aisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 38-313 1.4e-81 267.1 In-house 4-274 (280) alignment 
Range on Protein: 38-313
Range on HMM: 4-274/280.0
AIMSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHEC
 .|. . .....   . .||..  . | |||.|. ||.| || |. ||||  |  |  . .||||||||| | .||  |... |...    ..|||||| 
nvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhet

GSINRVYGFLDEVQRKYGAkggtTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVlEVANPSVEIDILWSDPDSTVDDFVDSTRG
 |.|..|||  |.| |||      .|  || ||  || ..|.| |.||||||.|  . ||. .||. ||. |  .  . ||.|||||    . .. | ||
psvnkiygfyvecqykygv....glwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpc.epldrgllidllwsdptnkgegwfhsirg

VGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMRP
.  .||   .    . |..||. |||||||||||..  .||.|.|| | || .| ||||.. .. ||  ||| . |
isymfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlip
subfamily_PPP4C_pd Subfamily PPP4C 39-311 4.2e-81 265.3 In-house 15-282 (288) alignment 
Range on Protein: 39-311
Range on HMM: 15-282/288.0
IMSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHECG
....... .|   |........ . ....|| .|||.|||. |.|.||. ||  |  |||||||.||||  |.|   |.||.||..| .  ..|||||. 
likeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesr

SINRVYGFLDEVQRKYGAkggTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRpVLEVANPSVEIDILWSDPDSTVdDFVDSTRGV
.| .|||| ||. ||||.   ...|.     | |.. .|.. |.|.|.|||.|  ...|...| ..|   || .  . .|.|||||. .   .  | || 
qitqvygfydeclrkygs...anvwryctevfdylslaaiidgkifcvhgglspsistldeirsidr.kqevphegplcdllwsdpedae.gwavsprga

GQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIM
| .||... .  ... |..|..||||.|..|| .  |....|..||| ||    | ||....|..|   |.|.
gylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkif
subfamily_PPP2C_pd Subfamily PPP2C 40-314 1.8e-80 263.3 In-house 17-286 (290) alignment 
Range on Protein: 40-314
Range on HMM: 17-286/290.0
MSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHECGS
...... .| . ||....|.  . |...|| .|||||||. |.| ||  ||  |  ||||||||||||  |.|  .|. | ||...    .||||||   
leesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrq

INRVYGFLDEVQRKYGAkggTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRpVLEVANPSVEIDILWSDPDsTVDDFVDSTRGVG
| .|||| ||. ||||.   ...|. |   | |.| |||| ..|.|.|||.| ... |...|.|.| . || .     |.||||||   . .. | || |
itqvygfydeclrkygn...anvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldr.lqevphegplcdllwsdpd.drggwgisprgag

QVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMRPS
  || .   .. .. .. |.|||||.| .||..  ....||||||| ||    | ||....|..|. ||  . |.
ytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpa
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 40-313 1.5e-75 247.2 In-house 6-299 (302) alignment 
Range on Protein: 40-313
Range on HMM: 6-299/302.0
MSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRG----------GFP-PLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNF
.|.. |..|..|  . . |. .. |. .|| | ||.|||. |..|..              .      ..|||||||||..|.|  || .|.|| .| |.
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

FMLRGNHECGSINRVYGFLDEVQRKYGAKGGTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVLEVANPSVEIDILWSDPDS--
 .||||||. .||  ||| .|.. ..| | |  .|. |. .|..|| .|||  .|||.|||||.... |.......||. ||.. |.  |.|..||    
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

------TVDDF-VDSTRGVGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMRP
      .  ..  .  ||.  ||   |.. . ..|...|. ||||..  |. || .|.|.|||||| |  | ||  |...|| |   | ...|.
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 40-313 2.4e-75 246.5 In-house 7-300 (302) alignment 
Range on Protein: 40-313
Range on HMM: 7-300/302.0
MSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRG----------GFP-PLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNF
.|.. |..|..|  . . |. .. |. .|| | ||.|||. |..|..              .      ..|||||||||..|.|  || .|.|| .| |.
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

FMLRGNHECGSINRVYGFLDEVQRKYGAKGGTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVLEVANPSVEIDILWSDPDS--
 .||||||. .||  ||| .|.. ..| | |  .|. |. .|..|| .|||  .|||.|||||.... |.......||. ||.. |.  |.|..||    
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

------TVDDF-VDSTRGVGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMRP
      .  ..  .  ||.  ||   |.. . ..|...|. ||||..  |. || .|.|.|||||| |  | ||  |...|| |   | ...|.
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_PPP6C_pd Subfamily PPP6C 41-316 1.5e-74 243.7 In-house 16-286 (290) alignment 
Range on Protein: 41-316
Range on HMM: 16-286/290.0
SQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHECGSI
... |. | |  .|........  ...|| .|||.|||. |.. ||  ||  |  .|.||||.||||  |||   ..|. |.|.| .  .||||||.  |
pendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqi

NRVYGFLDEVQRKYGAkggTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPvLEVANPSVEIDILWSDPDsTVDDFVDSTRGVGQ
 .|||| || ..|||    .. |. .   |  .. .|.. ...||.|||.| ... |.|.| ..|   |...     |..||||.  |.... |.|| | 
tqvygfydeclnkygn...anawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirviera.qeiphkgafcdlvwsdpe.dvetwavsprgagy

VFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMRPSID
.||.|  . ...  ...|..||||.|..|.... ...|||..||| ||    | |........ . ......   |
lfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpd
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 61-313 8.3e-73 238.3 In-house 1-255 (263) alignment 
Range on Protein: 61-313
Range on HMM: 1-255/263.0
AMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHECGSINRVYGFLDEVQRKYGAKG-G
|.|||.||..|||| |||| |.||.|.  |     .||||||||||| .||||  |... |. .| ....||||||  .||. |||  |.....  .   
allelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevy

TTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVLEVANPSVEIDILWSDPDSTVDDFV-DSTRGVGQVFGAKALTAIMNKLDVDL
 ...| |.  |.|||  |.|| |||||||||| ....|...| .  |.       .  |.||.||.     |  .  | . .||| | .  . ..||.||
esvynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidl

VARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIMRP
. ||||||. || || ..||.|.||| .|  |. | ||.. |.| |  ||  ..|
ivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 96-318 6e-72 235.6 In-house 121-338 (339) alignment 
Range on Protein: 96-318
Range on HMM: 121-338/339.0
NYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHECGSINRVYGFLDEVQRKYGAKggttMWNCFQICFAYMPYTALVSGRILCMHGGISKRMN
 |||||||||||  |.||  |. | |. .|   ..||||||  |.|  |||  ||. .| |.    ...|||  |  .|. |..   |.|||||||... 
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaq....lyecfqnmfnvfpfcavinntimcmhggisehlt

NLNQLRNLQRPvLEVANPSVEIDILWSDPDSTVDDFVDSTRGVGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAA
 .||.  ..|| ||. .  |  |. |.||| |   .  |.||   |||  || |...|||...| | ||||.||||||. .||||||||| |||. ||.|
sfnqfsvfkrp.leipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndnta

AMMNVDKNLTCSFQIMRPSIDAK
|.. .||.|  | ...||    |
avfsidkklkisinvfrpesrdk
subfamily_PPP3C_pd Subfamily PPP3C 37-303 1.9e-68 224.3 In-house 38-312 (452) alignment 
Range on Protein: 37-303
Range on HMM: 38-312/452.0
EAIMSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHE
|  ..... . ... | ... |. ..||.|||. ..||.|||. |.|.||. || |   .|||||||||||  |.|.   ..| |...| ..|.||||||
egrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhe

CGSINRVYGFLDEVQRKYGAKggttMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRpVLEVANPSVEIDILWSDPDSTVDDFV----
|  .   . | .|.. ||. .    ... .  .|  .| .||. .. ||.|||.|  ...|.....|.|   |. .     |.|||||    ...     
crhlteyftfkeeckikysee....vydacmesfdslPlaallnqqflcvhGGlspeikslddikkldr.fkeppasGplcdllWsdPledygeekteek

---DSTRGVGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNN------KRLVTIFSAPHYCGEFDNAAAMMNVDKN
   .|.||   ... || .  ..| |.  . |||.. ..||. ...        |.|.|||| |.. ..| ||......|
fvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 48-307 4.2e-67 219.5 In-house 28-285 (307) alignment 
Range on Protein: 48-307
Range on HMM: 28-285/307.0
LLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHECGSINRVYGFL
..  |. .|  . |..... |. . ||.|||. |.. .|   | ||   |.| |||||||  |||.  |...||. .| |  .||||||   .|. ||| 
viyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfy

DEVQRKYgAKGGTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVLEVANPSVeIDILWSDPDSTVDDFVDSTRGVGQVFGAKAL
.|.      | |  .|  || ||  .| .||.. .|||||||.|  .  |..|||  .|. .     |  |.||.||| .| ..  |.|| |  ||.. .
eecvtsi.pkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgiv.ndmlwadpdpsvfewkassrgsgftfgtnvi

TAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCS
  . ..| |.|. ||||.. |||  .  ..|.|||||| ||  . || ....||. |   
ddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiq
subfamily_PPP5C_pd Subfamily PPP5C 39-308 1e-66 218.1 In-house 33-303 (322) alignment 
Range on Protein: 39-308
Range on HMM: 33-303/322.0
IMSQKTLVSLLDAAKDVFMKQGAMLELEAP----VKICGDVHGQYSDVLRLFDRGGFPPLV-NYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRG
 . .|  ...|  ||... |. ...|.. .    . .|||.|||. |.| .|.  | |     ||| ||.||||  |.||. ..|..|. .| .||. ||
klhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrG

NHECGSINRVYGFLDEVQRKYGAKggttMWNCFQICFAYMPYTALVSGRILCMHGGISKR-MNNLNQLRNLQRPVLEVaNPSVEIDILWSDPDSTvDDFV
|||  ..|..||| .||. || .|    . . |.  | ..| . ..  ..| .|||. ..   .|..||...|   .  . .. ...|||||...     
nhesdnmnklyGfegevkakytek....vadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqpp.eegllvellwsdpqea.nGrs

DSTRGVGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNV-DKNLTCSF
 |.||||  ||    .  ... ...|. |.|.| ..|||. .. .|.|.|||| || . .| .|.... ...|.  |
pskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkf
PPP_2 69-265 9e-65 211.1 In-house 1-197 (198) alignment 
Range on Protein: 69-265
Range on HMM: 1-197/198.0
VKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHECGSINRVYGFLDEVQRKYGakgGTTMWNCFQI
|..|||.|||..|.|.||. |...|  .|||||||||||..|||| .|.||.|...| ....||||||. ..|.|||| .||..|.|   |..... .| 
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkg...gkkvykklqe

CFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPVLEVANPSVeIDIL----WSDPDSTVDDFVDSTRGVGQVFGAKALTAIMNKLDVDLVARAHQ
.|...| .||.....|..|||.|.....|.| .. .|..  ... .. .| |    .|||... . .  |.||.| .||... . ...| ...|. |||.
vfelLplaalidekvlvvHGGlseeiklldqikkeerkiespeegkl.ldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHe

V
|
v
subfamily_PPG1_pd Subfamily PPG1 39-311 1.8e-64 210.9 In-house 13-293 (300) alignment 
Range on Protein: 39-311
Range on HMM: 13-293/300.0
IMSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHECG
.. . |. .| |  |....|.  . |...|| . ||||||. ||| .|. ||  |  ||||||||||||  |.|   |... |...|    .||||||  
llpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesr

SINRVYGFLDEVQRKYGakGGTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRpVLEVANPSVEIDILWSDPD----STV------
 | .||||  |. ||||  | ...|. .   | |.  .|..   | |.|||.|  .  ..|.. |.|   || |     |.|||||.    .|.      
qitqvygfyteclrkyg..gnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldr.frevpnegaladllwsdpeennnptldhpdre

-DDFVDSTRGVGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSFQIM
 . || | || |  .| .    .... |.. . ||||....||. . ...| |..||| ||    | |..... ...   |...
gqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvy
PPP_4 69-265 1.3e-62 204.4 In-house 1-196 (197) alignment 
Range on Protein: 69-265
Range on HMM: 1-196/197.0
VKICGDVHGQYSDV-LRLFDRGGFPP-LVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHECGSINRVYGFLDEVQRKygakGGTTMWNCF
| ..||.|||. |. |.|.. ||.|.   .|.|||||||||..|||| .|.||.|...| ....||||||. |.|..||| .||..|     | .... .
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek....hgkeilkkl

QICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPvLEVA-NPSVEIDI-LWSDPDSTVDDFVDSTRGVGQVFGAKALTAIMNKLDVDLVARAHQ
| .|...|..||.....|..|||.|. ...|.......|.  |.  . ..  |. ||||| .. . . .|.||.| .||... . ...| ...|. |.|.
qdvfdllplaalidekvlvvhgglsdelesldkierierk.iespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshe

V
.
l
PPP_5_Dcr2 69-266 1.7e-61 200.6 In-house 1-199 (199) alignment 
Range on Protein: 69-266
Range on HMM: 1-199/199.0
VKICGDVHGQYSDV-LRLFDRGGFPP-LVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHECGSINRVYGFLDEVQRKYgakGGTTMWNCF
| .|||.|||. |. |.||..||.|.   .|.|||||||||..|||| .| ||.|...| ....||||||. ..|..|||..||..||   .|  ... .
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlsky...hgkkiykil

QICFAYMPYTALVSGRILCMHGGISKRMNNLNQLRNLQRPvLEVA-NPSVEIDI-LWSDPDSTVDD-FVDSTRGVGQVFGAKALTAIMNKLDVDLVARAH
. .| ..|..||.....|..|||.|. ......|....|.  |.  .. .. |. ||||| ..... .. |.||.| .|| ..   ...| ...|. |.|
sdvfdwlPlaalidekvlvvhgglspeiksiellekierk.ieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirsh

QVV
...
elk
subfamily_PPPLV_pd Subfamily PPPLV 45-303 3e-55 180.6 In-house 2-278 (290) alignment 
Range on Protein: 45-303
Range on HMM: 2-278/290.0
LVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLR---LFDR-GGFPPLVNYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHECGSI
|.|| | | |.....  .|||..|. . ||.||.| |.      . | |      ..||||||||||. |.|. . .|| || .|  ...||||||  |.
llslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesv

NRVYGFLDEVQRKYGAKGgTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLN---QLRNLQRPVLEVANP-SVEIDILWSDPDSTVDD------
   . .  | . |.| .    .|. |. .| ..| .| .  ...|.|.|| . .        ....   . . ..   . .|||||||..  |.      
qesieykgegsfkfgdsl.eevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgel

-----FVD-STRGVGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFdNAAAMMNVDKN
     ||| . || | ||...|| | ... ... | |||.| . |... .. ||.|.||. .|||   | ||.. |||.
vlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGss.neaalilvdkk
Metallophos Calcineurin-like phosphoesterase 68-266 3.8e-39 128.0 Pfam-A 2-199 (200) alignment 
Range on Protein: 68-266
Range on HMM: 2-199/200.0
PVKICGDVHGQYSDV----LRLFDRGGFPPLVNYLFLGDYVDRGQQSLEVACLF--LAYKVKFPGNFFMLRGNHECGSINRVYGFLDEVQRK--------
.. ..||.||.. |     |.|.. .. ..  ..|||||.||||  |.|. .|.  |..|...|...|.||||||....| .||||.|. .         
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

----------------------YGAKGGTTMWNCFQICFAYMPYTALVSGRILCMHGGISKRMNNLNQLrnlqrpvlevanpsveidilwsdpdstvddf
                       . ..|.  .  ....|...|  ||| |.||..||..|.. .. ..                                
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

vdstrgVGQVFGAKALTAIMNKLDVDLVARAHQVV
       .  || .||  . .| .|||| |.|. .
......gselfgpdalekllekygvdlvlrGHtHk
subfamily_PPP7C_pd Subfamily PPP7C 67-206 3.2e-36 117.8 In-house 64-202 (383) alignment 
Range on Protein: 67-206
Range on HMM: 64-202/383.0
APVKICGDVHGQYSDVLRLFDRGGFPPLV-NYLFLGDYVDRGQQSLEVACLFLAYKVKFPGNFFMLRGNHECGSINRVYGFLDEVQRKYGAKGgTTMWNC
  | .|||.||.  |.| .. . |.|    .|.| ||.||||..|.|.....||. . .| .... |||||   .|  |||. ||. ||  .| . . . 
kevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhg.kkilrl

FQICFAYMPYTALVSGRILCMHGGISKRmNNLNQLRNLQRP
..  ||..| ..|.  .|| .|||||..  .|. | ...| 
ledvfawlplatlidekilivhGGisdk.tdlelldkiers
subfamily_PPP7C_pd Subfamily PPP7C 217-308 5.7e-19 61.1 In-house 238-329 (383) alignment 
Range on Protein: 217-308
Range on HMM: 238-329/383.0
IDILWSDPDSTVDDFVDSTRGVGQVFGAKALTAIMNKLDVDLVARAHQVVQDGYEFFNNKRLVTIFSAPHYCGEFDNAAAMMNVDKNLTCSF
.||||||| ..   . .. || |  ||.   . ...| ...|. |.|.  ..||||  .|...|||||  |  |  |  | ... |.||  .
ldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpri
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 37-92 2.7e-13 42.8 In-house 6-61 (317) alignment 
Range on Protein: 37-92
Range on HMM: 6-61/317.0
EAIMSQKTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFP
. ....| |. |   |...| |.  .|||||||.|.||.|||. |.| |.|  |.|
qdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 43-92 1.3e-07 24.1 In-house 14-63 (339) alignment 
Range on Protein: 43-92
Range on HMM: 14-63/339.0
KTLVSLLDAAKDVFMKQGAMLELEAPVKICGDVHGQYSDVLRLFDRGGFP
  |  |   |...   .  .|.||||. . ||.|||. |.| ..|  |.|
aelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwp
subfamily_YNL217W_pd Subfamily YNL217W 71-140 1.7e-07 24.0 In-house 14-79 (235) alignment 
Range on Protein: 71-140
Range on HMM: 14-79/235.0
ICGDVHGQYSDVLRLFD--RGGFPPLVNYLFLGDYVDRGQQSLEVACLFlaykvkFPGNFFMLRGNHECGSI
. ||||| | ....|.|   ||  . |  ...|| ...| .|.||  .          .   ..||||   .
vvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvl