Gene tap-1 in Caenorhabditis elegans

Synonym: CELE_C44H4.5, tap-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily TAB1
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP192_AA protein Get Run
CeleP192_AA_13-328 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_TAB1_pd Subfamily TAB1 20-328 5.4e-120 393.2 In-house 1-332 (333) alignment 
Range on Protein: 20-328
Range on HMM: 1-332/333.0
TVHSCRYSKQKNPVQNNDFLScsmCIHNGPIkLYGIFSGFNgGDSTAKFVMNRLVYEIFGENpITPTLLPYQVVEEFKRKFENVAERYL------LMNTD
.|...||||....|....||.   ...|.|| ||..|.|.. |...||||..|||.|...|. .|..|....|.|..||.||.|....|      |...|
svsnrryskedhevedkvflf...ktendpi.lyavFdGyd.GnkaakfveqrLvaellleq.ltdelaeaevkevlkrafeeverkflesiddalaekd

DLNNRL------LKLEEQSETGNNAVSEINQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMN---SENVVQLNSNlHNNDNPLEIVRIKGLGINPETV-
||...|      ..||||.........|....|..||||.|..|.|..|||.|.|.|.|....   ||.|.||... |..||. |..|.|.||...|.. 
dlqsqlPegvssyeleeqypekierlqeleeeisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvd.HttdNedEllRlkdLGldieqik

-------LNPTRAIGDLQRTHLFEETEAFKNAKGPPVISTPDVQYT-KIDPSWRHLVLISDGVVQNLKEV------EVENIPTEVSVRLIEDHTVTSTAQ
        ..||.|||...............|||.|||..||.|.. .||.....|||.||||...|.||      .||||..||...|....|....||
rnkrlgskentRsiGdykvkkgykdvdilssakgePviaePdiqgaypiddityflvlmSdGvyktLeevtgpetsnvenillevitelekqatlqdvAq

ALVDSFARKHRDAYTMSDDKNFCISNHREEMTVIYVKLE
|.||...|||.|||..|......|...|..||....|.|
avvdkvkrkHkdaylssaseravicrkrddmtllvlkfe
PPM_PTC7 56-293 3.3e-40 131.1 In-house 11-257 (259) alignment 
Range on Protein: 56-293
Range on HMM: 11-257/259.0
FSGFNGGDSTAKFVMNR-LVYEIFGENPITPTLLPYQVVEEFKRKFE-NVAERYLLMNTDDLNNRLLKLEEQSETGNNAVS-EIN-QKIRQGTTAIVVMI
|. .. .. .|.. ...   .. ...  .    . ... . .. ..|  ..||. ......|...| |  .. .| ..  | | | .....|.||.|..|
frksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepstsGstAvvali

INQDLYVLNCGNSLAIAMNSENVVQLNSNLHNNDNPLEIVRIKGLGINPETVlNPTRAIGDLQRTHLFEETEAFKNA-KGPPVISTPDVQYTKIDPSWRH
....||| |.|.| |. ..|.|.|.  .. |. .|. |. ||.|.| . ..| . .|  | |. .. |  .| ...  . ..|...||.. ||||... .
tgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnv.gngrvngvlavsRafGdfelkpketeeqlvsaePdisstkideedef

LVLISDGVVQNL-KEVEVENIPTEVSV----RLIEDHTVTSTAQALVD
|.|.|||..... ..  |.....|.|     ...|..  .. |.. .|
liLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargsed
PP2Cc_SM00332 14-325 5e-38 124.0 In-house 4-274 (274) alignment 
Range on Protein: 14-325
Range on HMM: 4-274/274.0
TDAGIGTVHSCrYSKQKNPVQNNDFLSCSMCI-HNGPIKLYGIFSGfNGGDSTAKFVMNRLVyEIFGENPITPTLL-PYQVVEEFKRKFENVAERYLLMN
.. . |  ...  |.|.......|.  . ..  ..    ..|.| |  ||...||||...|. |.. |.. . .     .| |  |. |... |..| ..
sgsnlglsygk.ssmqgwrksmeDahvvvvdlveeedwlffgvfDG.hgGsevakfvskklp.ealkeelkkkkdeleddveealkkaflstdeeileee

TDDLNNRllkleeqsetgnnavseinqkIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLnSNLHNNDNPLEIVRIKGLGI-----NPETVLNP
   ....                      . |.||.|... ..|||| |.| | |. ......||| |. |. ... |. |||  |          .|. 
qskelen.....................alsGstavvallkkedlyvanvGDSravlcrngkavql.svdhkpedederkRikkaggvvekgrvngglav

TRAIGDLQRT--HlfeeteafkNAKGPPVISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVENIPTEVSVRLiEDHTVTSTAQALVDSFARKhrdayt
.||.|| .              . | | ....|||.......... |.|.|||. ..|...|| .| ..   .  ... ..  |. |..  .|.      
srafGdhflkknk.........klkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg.ktndpqeaaelldeeairr......

msddknfciSNHREEMTVIYV
          .... .||. |
.........ggseDniTvvvv
0034914 PP2C-like 20-328 1.2e-32 106.1 In-house 20-291 (295) alignment 
Range on Protein: 20-328
Range on HMM: 20-291/295.0
TVHSCRYSKQKNPVQNNDFLSCSMCI--HNGPIKLYGIFSGFNgGDSTAKFVMNRLVYEIFGENPIT---PTLLPYQVVEEFKRKFENVAERYLLMNTDD
 .... .| | .   | |. .. ...  ..... |.|.| |.. |...|......||.... .   .    || . ...| ... | .. |..| .. ..
llrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhg.Ghaaaevasellvelllellekllllltlsledieealrkaflaadeellelallr

lnnrllkleeqsetgnnavseiNQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMnSENVVQLNSNLHNNDNPLEIVRIKGLG--INPETVL---NPTRA
                      .. .. ||||.|..|... ||| |.|.| |. . ......  .. |. .|.||. ||. .|  .. . |.   . |||
......................pelagsGtTavvalirgnklyvanvGDSravll.rngelvqltvdhkpvnelererilsaggavshgrvngvlavtRa

IGDLQRTHLfeeteAFKNAKGPPVISTPDVQYTKID-PSWRHLVLISDGVVQNLKEVEVENIPTEVSVrliEDHTVTSTAQALVDSfARKhrdaytmsdd
.|| .  .|      .  ...|.|...|||...... ...  |.| |||. ..| . |. .| ...     . ....  |..|||  | .          
lGdfdlkll.....lslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrslla...kgldleeaaeeLvdl.Ala..........

knfciSNHREEMTVIYVKLE
      ..|. .||. |.|.
.....rgsrDNiTvvvvrln
PP2C Protein phosphatase 2C 112-266 1.9e-21 69.8 Pfam-A 73-220 (255) alignment 
Range on Protein: 112-266
Range on HMM: 73-220/255.0
TDDLNNRLLKlEEQSETGNN--AvseiNQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNSNLHNNDNPLEIVRIKGLGINPE------TV
 . |..  |. ....|. ..  .    .. .. |.||.|..| ...||| |.| | |. . . | ..  .. |  ... |. ||...|   .       .
ekalrksfla.dtdeelksskan....tepsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngs

LNPTRAIGDLQRTHLFeeteafknakGPPVISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVE
|. .||.||..    .           ..|.. |||. .|.....  |.| |||. . |.. |
LavsRalGdfelkpke..........eqlvsaePdvtsvklteedefliLasdGlwdvlsdqe
PP2C Protein phosphatase 2C 112-266 1.9e-21 69.8 In-house 73-220 (255) alignment 
Range on Protein: 112-266
Range on HMM: 73-220/255.0
TDDLNNRLLKlEEQSETGNN--AvseiNQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNSNLHNNDNPLEIVRIKGLGINPE------TV
 . |..  |. ....|. ..  .    .. .. |.||.|..| ...||| |.| | |. . . | ..  .. |  ... |. ||...|   .       .
ekalrksfla.dtdeelksskan....tepsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngs

LNPTRAIGDLQRTHLFeeteafknakGPPVISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVE
|. .||.||..    .           ..|.. |||. .|.....  |.| |||. . |.. |
LavsRalGdfelkpke..........eqlvsaePdvtsvklteedefliLasdGlwdvlsdqe
subfamily_PPM1A_pd Subfamily PPM1A 29-293 5.2e-19 61.7 In-house 20-262 (282) alignment 
Range on Protein: 29-293
Range on HMM: 20-262/282.0
QKNPVQNNDFLSCSMCIHNG-PIKLYGIFSGFnGGDSTAKFVMNRLVYEIFGenpitptllpyqvVEEFKRkfENVAERYLLMNTDDLNNRLLKLEEQSE
|   |.. |  .. ... .    ... .| |  .|.. ||.| . |. .| .              ||.|   ..  ..      . |.. .|.|.|. .
qgwrvemEDahtvvaslgalkdwsfFavfDGH.aGsevakyvkkhllenile.............eeelke..aaleasekdevkealrqgfLaldeair

TGNNAVSEInqkIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVvQLNSNLHNNDNPLEIVRIKGLG--INPET---VLNPTRAIGDLQrthlFEET
. .. ...     . |.||..|.. .. |.. |.| | |. .. ... . ... |  ..| |  ||.  |  .  .     |  .||.|| .    ..|.
elstdlkta...dksGsTavtvlvsekhliianlGDsRavlcrngka.aflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDye....ykee

eAFKNAKGPPVISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVENIpteVSVRLIEDHTVTSTAQALVD
   |.|.   |.. |.|. .... .  .||| .||.   |.. || ..   |  ||   . ... |.||||
.eekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvel...vrkrlevadeleevakalvd
subfamily_PPM1G2_pd Subfamily PPM1G2 17-296 2.5e-18 59.0 In-house 22-265 (287) alignment 
Range on Protein: 17-296
Range on HMM: 22-265/287.0
GIGTVHSCRYSKQKNPVQNNDFLSCSmciHNGPIKLYGIFSGFnGGDSTAKFVMNRLVYEIFGenpitptllpyqvveefKRKFE-NVAERYLLMNTDDL
|  ..   | ..    ...|..|. |    .  . |...| |  ||.. ||.. ..|.  |                   |..|. .  |. |     ..
gssamqGyrlnmeDahilenelleks...ddkslalfavfDGh.GGakvakyagkklikkiak.................kksfkegaleqilkdaflet

NNRLLKLeeqsetgnnavsEINQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLnSNLHNNDNPLEIVRIKGLGI--NP---ETVLNPTRAI
.. |||             |  ..   |.||.||.|....||| |.|.| |.. .. || .| |  |  ..  |  ||.  |   .      .|   ||.
Deellkd............eklkdesaGstavvvlikeeklyvanaGDsravlsskgnvkal.sfDhkPqeesekkriiaagGfvelnrvngnLalsral

GDLQRTHLFEeteafKNAKGPPVISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVENIpteVSVRLIEDHTVTSTAQALVDSFA
|| .  .  .     |...   |  .|||  .|.|...  |||  ||.   |.. || ..   |  || ..... . .. |.|.  
gDfefkknvk.....kkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdl...vrerlvsgakldeiieelldkcl
0049733 PP2C-like 27-297 3.9e-18 58.9 In-house 9-219 (235) alignment 
Range on Protein: 27-297
Range on HMM: 9-219/235.0
SKQKN-PVQNNDFLSCsmcihngPIKLYGIFSGFNgGDSTAKFVMNRLVYEIFgENPITptLLPYQVVEEFKRKFENVAERYLLMntddlnnrllkleeq
| ...    | |.. .        . |.... | . |   .... ..||  .  |   .  ||.....| ... |. . |..| .               
sdigrvrkvneDavlv.......glllfavaDGhg.ghaagevasellvetll.ellle..lllldleealrkaflaaneallel...............

setgnnaVSEINQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNSNlHNNDNPLEIVRIKGLG--INPETVLNPTRAIGDLQRThlfeete
       . . ..  . ||||.|...... |||.|.|.| |. ......|||. . |.  |.||  ||. .|  ..   .|  |||.|||.         
.......alaspelagmgtTavvalldggklyvanvGDsrayllrdgklvqlted.hspvnelerqriitaggavrvpgrlaltralGdlllk.......

afknakgppvistPDVQYTKIDPSWrHLVLISDGVVQNLKEVEVENIPTEvsvrliedHTVTSTAQALVDSFAR
             |||......|    |.| |||.  .| . |. .. ..        ...   |..||.   .
.............pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs........ldleeaaerlvelala
PPM_PTC7_SpoIIE 52-261 1.4e-12 41.0 In-house 36-197 (230) alignment 
Range on Protein: 52-261
Range on HMM: 36-197/230.0
LYGIFSGfNGGDStaKFVMNRLVyEIFGENPiTPTL-LPYQVVEEFKRKF-ENVAERyllmntddlnnrllkleeqsetgnnavseinqKIRQGTTAIVV
..|...|  ||..  ...|..|  ... |.  ...| .| .....  ...  .  ..                                 .  |.||.|.
vvgdvdG.hGgra..alamgllr.talrela.faglekpeeilrrlnlalaadlede................................psssgaTavva

MIINQD--LYVLNCGNSLAIAMNSeNVVqlnsnlhnndnplEIVRIkGLGINPEtV-LNPTRAIGDLQRTHLFEETEAFKnaKGPPVISTPDvQYTKIDP
 | ...  ||| |.|.| .. ... .               |. || ..|  |. . . |.|  |.|. .  . ..  .   .   | . || . .....
lidpstgklyvanaGdsppllvrd.dgg.............ereri.vagglps.lGilpgrvfgvlavslapGdlllly..tDGvveaepd.tsdgelf

S-WRHLVLISDGVVQ--N
. ...|.|.|||. .  .
gkdeflilasdglwdvls
subfamily_PPM1E_pd Subfamily PPM1E 136-293 5.5e-11 35.1 In-house 96-244 (265) alignment 
Range on Protein: 136-293
Range on HMM: 96-244/265.0
INQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNsNLHNNDNPLEIVRIKGLGINPETVlNPTRAIGDLQRTHlfeeteAFKNAKGPP-VI
...|.. |.||.||.| .. |||   |.| |. ..  ..|||  . |. ... |  ||. .|     . .  |  | |. .       |  ..|  | |.
ereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlm.kpHkPeredEkkRieeagGlvvvi.gawRvnGvLsvsR......aiGDvklkpyvs

STPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVENIpteVSVRLIEDH-TVTSTAQALVD
. .||  ...| |   |.| .||.   ..| || ..   |.  | ... . .. |. ||.
geadvaeveldgseeylilacDGlwDvvneeevvkl...veefladgaedlsevakllve
subfamily_PDP_pd Subfamily PDP 120-289 1.2e-10 34.1 In-house 130-326 (398) alignment 
Range on Protein: 120-289
Range on HMM: 130-326/398.0
LKLEEQSETGNNAVSEINQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVV-----QLnSNLHNNDNPLEIVRIKGLGINPET-----------V
.. | .... .. . |  ..   |..|....| ...|.| | | . |.   .|.       .| |. .. ||. |. |||    . |             
istealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkL.skdqtadneeEveRikkeHPgeesktvirngRlLge

LNPTRAIGDL--------QRTHLFE---ETEAFKNAKGPP-VISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVENIPTEVSVRLIEDHTVTSTAQ
| |.|| ||.        |...| .   .. . |. | || ....|.|.. |. .. . ||| .||  . |.. || .. .|   .  |.. |... .
LqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepvkveea
subfamily_PPM1G_pd Subfamily PPM1G 140-268 1.6e-10 33.6 In-house 294-422 (473) alignment 
Range on Protein: 140-268
Range on HMM: 294-422/473.0
IRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLnSNLHNNDNPLEIVRIKGLG--INPE----TVLNPTRAIGDlqrtHLFEETEAFKNaKGPPV
   ||||.|... ...|.| | |.| ..  .. . ..| |  |  ... |  ||.  |  .. .      ||  ||.||    | . ..|  .. |   .
edsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldl.slDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGD....haYkkneeLpl.keqmi

ISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVE
   ||.. ... .    ||| .||.   ..  || 
sAlPDikvltlteedeFlvlAcDGiWnvmesqevv
subfamily_ILKAP_pd Subfamily ILKAP 140-274 8.6e-09 27.9 In-house 111-242 (293) alignment 
Range on Protein: 140-274
Range on HMM: 111-242/293.0
IRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQ--LNSNL---HNNDNPLEIVRIKGLGINP-----ETVLNPTRAIGDLQrthlfeeteaFKNAk
 . |.||.||..... ||| | |.| |. .  ..  .      |   |.  .  |  ||.  | .        ||. .|.||| .          ||.. 
WkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgr..........fkrl.

GppVISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVENIPTEV
|  |||||||.  ....  ...||  ||. . ..  || .  ..|
G..vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkv
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 132-269 6.1e-08 25.2 In-house 87-218 (255) alignment 
Range on Protein: 132-269
Range on HMM: 87-218/255.0
AVSEINqkIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNSNLHNNDNPLEIVRIKGLGINPETVLNPTRAIGDLQRTHLFEetEAFKNakgP
 .||    .. ||||..|.||..  |. | |.| ..  . . . .  |  |.  .. |  ||. || .  .    .|  | |  .  .   ..| .   |
qiserp..kfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralG..dsfle...P

PVISTPDVQ-YTKIDPSWRHLVLISDGVVQNLKEVEVEN
 |.. ||..   .|  . ..|.|  ||.   . . |  .
fvvpdPdlsqsleiskkdkflilacdGiwdlisdeeave
DUF1202 Protein of unknown function (DUF1202) 104-157 8.4e-08 18.1 Pfam-A 125-178 (308) alignment 
Range on Protein: 104-157
Range on HMM: 125-178/308.0
AERYLLMNTDDLNNRLLKLEEQSETGNNAVSEINQKIRQGTTAIVVMIINQDLY
 ..||..|..|.|.|. .|... .. .. ..|.......  . |||.  . | |
ndkylivnsedfnyrfsalkseyarkkssinelekdvkaldkkivvakkeaday
PP2C_SIG_SM00331 123-296 1.2e-07 24.5 In-house 60-194 (217) alignment 
Range on Protein: 123-296
Range on HMM: 60-194/217.0
EEQSETGNNAVSEINQKIRQG-------TTAIVVMI--INQDLYVLNCGNSLAIAMNSENVVQ-LNSnlhnndnpleivrikglginpetvlNPTRAIGD
 .. |.  .|....|. |..        .|... ..   .. |...|.|.|  . ..... |. | .                         ......| 
lsegeelsqalkrlnraiyeekeekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd.........................vegaplGl

LQRTHlfeeteafknakgppvistPDVQYTKIDPsWRHLVLISDGVVQNLKEVEvenIPTEVSVRLIEDHTvTSTAQALVDSFA
 .                      .|.. .....    |.| .||.. . .| .   . .|   ...||.. .|.||.| ... 
epevs...................vdirelelek.gdllllytDGltearsekg...faeerleeiledlv.dseaqelaqkiv
subfamily_PPM1L_pd Subfamily PPM1L 46-266 6.7e-07 21.8 In-house 31-227 (269) alignment 
Range on Protein: 46-266
Range on HMM: 31-227/269.0
HNGPIKLYGIFSGFnGGDSTAKFVMNRLVYEIFGENPITptllpyqvveefkrkfENVAERYLLmntddLNNRLLKLEEQSETGNNAVSEINQK-IRQGT
..  ......| |  ||. .|.|. ..|| .|  .                    ..  |. .      .|   |  .|     .. . .....    ||
nktgesffavfdGh.GGefaaefakdvlvkaiknkliel................dadkentep.....infsklltdeilsvdekllekakraediaGt

TAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNSNLHNNDNPLEIVRIKGLGINpETVLNPTRAIGDLQRTHLFEEtEAFKNAKgpPVISTPDVQYTKI
||.. .. ..|| | | |.|  . .. .      |  |   .. |  |||  |    .     |  | |  .  . .   .|. .   ||..||.   ..
talialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGf.iafrGvwrvaGvlatsralGd.yplkdkn..lviadpdiltfdl

DPS-WRHLVLISDGVVQNLKEVE
|    . |.| |||. . . . |
ddhkpeflilasdGlwdtfsnee
subfamily_PPM1H_pd Subfamily PPM1H 138-181 2.4e-06 19.6 In-house 158-201 (404) alignment 
Range on Protein: 138-181
Range on HMM: 158-201/404.0
QKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNSNL
 .|. | ||.|...... ||| | |.| || ........| ...
yrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadf
subfamily_PPM1D_pd Subfamily PPM1D 54-197 5e-06 18.8 In-house 39-168 (309) alignment 
Range on Protein: 54-197
Range on HMM: 39-168/309.0
GIFSGFnGGDSTAKFVMNRLVYEIFGENPItPTLLPYQVveefkrkfenvaeryllmnTDDLNNRLLKLEEQSETGNNAVS--EINQKIRQGTTAIVVMI
..| |  ||   |||. ..|. .|  .. .  .  | .|                   .. ...  |...|. .   .  .  . ..    |||| ||.|
avfDGH.GGkeAakfarehlwsvikkqkkf.lssepedv...................leAireaflatheamkkkleeWpktksgllstaGttasvvii

INQDLYVLNCGNSLAIAMNSEN-----VVQLNSNLHNNDNPLEIVRIKGLG
 ...||| . |.| ..   .|.     . .   . |  ..| |  ||. ||
rreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelG
Joubert Joubert syndrome-associated 285-351 9.8e-06 11.3 Pfam-A 215-281 (329) alignment 
Range on Protein: 285-351
Range on HMM: 215-281/329.0
TSTAQALVDSFARKHRDAYTMSDDKNFCISNHREEMTVIYVKLEEDYQAALYEQFDSAISTMESTNA
.|.| .     ..... |   .  |. || . |||. |    | .. .. | |. .| .  ...|. 
gsnapckslqhtksrgsaglapqtkqvcieyereetvvsPWllPseirkilheshssllqdlsptee