Gene W03D8.2 in Caenorhabditis elegans

Synonym: CELE_Y40H4A.2, Y40H4A.2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP198_AA protein Get Run
CeleP198_AA_45-312 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP1C_pd Subfamily PPP1C 42-309 3.7e-112 367.1 In-house 5-262 (282) alignment 
Range on Protein: 42-309
Range on HMM: 5-262/282.0
QLRVDITISEISQLTDKMKKAFLEQPALLEISnEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRG
. .|... .||..|..|.....|.||.|||.. .|...|.|.|||  .|||.| |..|||...|||||||||||.||. ...||...|..||...|||||
gkevklkeaeieallkkareillsqpillele.aPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrG

NHEDVNTTLNYGFYDECLEQWKNDegekVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLLWSDPaQPERNGWGL
|||.....  ||||||| ......    .|..|.|.|||.||||..  |..|.|||.||.|.|||.|..|.||| || .||.|||||||| . |..||. 
nhesasinriyGfydeckrrysik....lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdp.dkevlgwse

SHRGISFTYGKSVVEEFCAKNDIALVIRGHQLFKEmypqGCVLRFGGRLISLFSALNYEGHKNNSSVL
..||.|||.||.|||.|..|||. |..|.||....    |. .    .|...||| || |. .|....
ndrGvsftfgkdvvekflqkndldlivrahqvved....Gyeffakrqlvtvfsapnycgefdnagav
0045823 Metallo-dependent phosphatases 46-312 3.7e-90 295.8 In-house 42-312 (473) alignment 
Range on Protein: 46-312
Range on HMM: 42-312/473.0
DITISEISQLTDKMKKAFLEQPALLEISNePITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHED
 .. ... .| |..|. . ..| |||.|  .|.|. | |||   |||..  .. ||.....||||.||||..|. |..||...| .||..|||||||||.
llpeedllklldeakeilkkepnllelsm.rivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHEl

VNTTLNYGFYDECLEQWkndeGEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLLWSDPaqPERNG-------
 . .  |||.||.||.     ||.....|.. ....|||||||||....|||.|| |..|..|..||||| .| .||..|||||||   | .|       
rllnglygfgdetleky....gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP..weddgdgllrlr

-WGLSHRGISFTYGKSVVEEFCAKNDIALVIRGHQLFKEmypqGCVLRFGGR------LISLFSALNYEG-HKNNSSVLKLE
 .| |.||.....|. .||||. ||.. |..|||.   |    |  | |.|.      .|..||| || | ..| ..||...
ffgnsprgagylFgpdaveeflkkngldlivrGHthvpe....GyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvid
PP2Ac_SM00156 49-311 3.2e-85 278.4 In-house 3-256 (271) alignment 
Range on Protein: 49-311
Range on HMM: 3-256/271.0
ISEISQLTDKMKKAFLEQPALLEISnEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDVNT
 .|. .| ...|. . ....|.|.| .|.||| |.|||   |||.. ... ||..||.|||||||||.||. |..|||..| .||..|.|||||||. ..
keevlelleevkeilkqeknlvevs.apvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TLNYGFYDECLEQWkndeGEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLLWSDPaQPERNGWGLSHRGISF
.  |||..|.  .     |.... .| ..|...||||... |..| |||.|| ||||.||....|.   |  ||..||||||| . . .|.  | ||.|.
nkiygfeeevkrky....gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdp.eqkekgfqpskrglsv

TYGKSVVEEFCAKNDIALVIRGHQLFKemypQGCVLRFGGRLISLFSALNYEGHK-NNSSVLKL
..|...|.||. ||.. |.||.|.. .    .|  ... ..|...||| ||...  |  .|||.
vFgedavkeflkknnlkliiRahevvd....eGyeffadkklvtifsapnycdefsnkaavlkv
0049330 Metallo-dependent phosphatases 47-307 1.2e-82 270.5 In-house 30-280 (309) alignment 
Range on Protein: 47-307
Range on HMM: 30-280/309.0
ITISEISQLTDKMKKAFLEQPALLEISnEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDV
.. .|. .| .|.|. ....| |||.|  .|.|. | |||   |||..  .. ||.....||||.||||..|. |..||...| .||..|||||||||. 
lseeellllllkakeilksepnllels.mrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvfllrGNHElr

NTTLNYGFYDECLEQWkndeGEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLLWSDPaQPERNGWGLSHRGI
. .  |||.||.|...    |...|..|.|.....|||||||||..|.|||.|| | .|..|...|||| .| .|| |||||||| .|.|.|.. ..||.
llnglygfgdetlrky....gaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdp.lpiregfapnprgl

SFTYGKSVVEEFCAKNDIALVIRGHQLfkemYPQGCVLRFGGRLISLFSALNYEGHKNNSS
....|  .||.|. ||.. |.||||..    ...|.   |.|.||..||| || |. .|  
gvvfghtaverflkkngldliirghga....vfgGyltffdgklitvfsapnycgrlgnlg
PPP_3 48-312 2.7e-81 265.5 In-house 3-259 (271) alignment 
Range on Protein: 48-312
Range on HMM: 3-259/271.0
TISEISQLTDKMKKAFLEQPALLEISnEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDVN
. .|. .|..|.|. . ... |.||| .|.||. |.|||   ||..| .   .|..||||||||||||..|. |..||...| .||..|.|||||||. .
senelkelvkklkeilekesnlveis.apvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

TTLNYGFYDECLeqwKNDEGEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLLWSDPAQpERNGWGLSHRGIS
 .  |||..|.|   |.  |.||.... ..|...||||.| .||...|||.|| ..||..|...||. .||  |. .|||.|.... ...|.. |.||..
inkvYgFkkevl...kkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpe.keeglenskrGag

FTYGKSVVEEFCAKNDIALVIRGHQLFKEmypqGCVLRFGGRLISLFSALNYEGH-KNNSSVLKLE
...|..|.|||. ||.. |.|| |.| .|    |  . . |... .||| || .. .|  ..||||
llFgpdvteefleknkLkliiRaHelkee....GyeilhdgkvvtvfSapnycerasnagailkle
0053225 Metallo-dependent phosphatases 47-306 3.3e-78 256.0 In-house 22-271 (293) alignment 
Range on Protein: 47-306
Range on HMM: 22-271/293.0
ITISEISQLTDKMKKAFLEQPALLEISNePITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDV
.. .|. .| ...|. ....| |||.|  .|.|. | ||.   ||...   . ||. ...||||.||||..|. |..||...| .||..|.|||||||. 
lseeelllllleakeilkkepnllelsm.riyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNHElm

NTTLNYGFYDECLEQWKndeGEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLLWSDPAqpERNGWGLSHRGI
. .  |||.||.|...    ....|....|.....||||.||||....|||.|| | .|..|..|.||| .| .|| .|||||||   ...||. |.||.
llnglygfgdetlrkyg...aaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd..lwsgwlpsyrgl

SFTYGKSVVEEFCAKNDIALVIRGHQLfkemYPQGCVLRFGGRLISLFSALNYEGHKNNS
....|  .|..|. ||.. |.|||||.    .|.|    |.|.|. .||| || |. .| 
gvvfghtavlrflkkngldliirghqv....vpdgylpwfdgklvtvfsapnylgrlgnl
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 41-324 6.6e-78 254.8 In-house 18-290 (298) alignment 
Range on Protein: 41-324
Range on HMM: 18-290/298.0
NQLRVDITISEISQLTDKMKKAFLEQPALLEIsNEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLR
..|   |. .....| .. || | .|..|.|. . ||.|  |.|||   |||.|  .  ||.. |||||||||||.|.. |..||.. | .||...||||
kkltkvikeedveklielakkifkkqkslvev.dapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllr

GNHEDVNTTLNYGFYDECLEQWKNDEgekVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLLWSDPAQpERNGWG
||||      .||||.|| .. |. .   ..  | |.|| .||.|.|||...| |||.|. |.||.......||   .   || ||||.||..   .|| 
GnheceainrvyGfyeeckrrykslr...lyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpen.avkgwa

LSHRGISFTYGKSVVEEFCAKNDIALVIRGHQLFKEMYPqgcvLRFGGRLISLFSALNYEGHKNNSSVLKleFVGQRVKVKQVL
 ..||.|...|. ||.... | || ||.|.||. .. |     .  . .|...||| .| |. .||. .    | ....|  ..
ensrGvsvvfGedvvkdllekldidlvvrahqvvqdGye....ffaekklvtifsaphycgqfdnsaavm..kvdeklvvsfev
PPP_1 50-307 3.3e-76 249.1 In-house 4-259 (264) alignment 
Range on Protein: 50-307
Range on HMM: 4-259/264.0
SEISQLTDKMKKAFLEQPALLEISnEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDVNTT
.|. .| .|.|. . ... |||.| |.|||. |.|||   ||..| .   .|...|||||||||||..|| ...||...| .||...||||||||. . |
eelaelkkklkellnkeenllevs.eeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

LNYGFYDECLeqwKNDEGEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLL-------WSDPAQpERNGWGLS
  |||..|.|   |.  ........ |.|...||||.| .|... |||.|| |..|..|. ..|  .||  | .||||       .||. . .....  |
kvygFkkEvl...kkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddke.qeeavans

HRGISFTYGKSVVEEFCAKNDIALVIRGHQLFKEmypqGCVLRFGGRLISLFSALNYEGHKNNSS
.||.....||.|.|.|. ||.. |.|| |.. .|    |  . . ......||| ||  . .| .
iRGagylfgkdvtekflqknnlkliiRaHevkee....Gyeflkkrkvvtifsasnyyeegsnrg
subfamily_PPZ_pd Subfamily PPZ 46-306 3e-75 246.5 In-house 24-274 (300) alignment 
Range on Protein: 46-306
Range on HMM: 24-274/300.0
DITISEISQLTDKMKKAFLEQPALLEISNePITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHED
 .  ||| |.  | .. || ||||||.|  .. .| |.|||   |||.|     ||  .||||||||||| ||.  . ||.| | .||. .|||||||| 
clknseilqicikarelflaqpallelsp.svkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhec

VNTTLNYGFYDECleqwKNDEGEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLLWSDPAQpERNGWGLSHRG
 | |  |||||||    |     |.|. |.|||| .||||.. ||.|| |||.|| |.|...|  . ||  || .||  |||||||..   | |    ||
anvtrvygfydec....krrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptd.ssnewednerg

ISFTYGKSVVEEFCAKNDIALVIRGHQLFKEMYPqgcvLRFGGRLISLFSALNYEGHKNNS
.|. | |  ...|  |  . || | | . .. |     .     |...||| || |  .| 
vsycynkvainkflnkfgfdlvcrahmvvedgye....ffndrslvtvfsapnycgefdnw
subfamily_PPP2C_pd Subfamily PPP2C 47-309 5.5e-73 238.7 In-house 17-270 (290) alignment 
Range on Protein: 47-309
Range on HMM: 17-270/290.0
ITISEISQLTDKMKKAFLEQPALLEIsNEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDV
.. ||. .|..|.|. . ..  . |. . |.||. |.|||   || .|      |. .|||||||||||  ||  ..|| ..| ||.. . .||||||  
leesevkelcekakeilskesnvqev.kcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesr

NTTLNYGFYDECLEQWKNdegEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLLWSDPAqpERNGWGLSHRGI
. |  |||||||| .. |    .||..| | |...||.|.. ...|| |||.|| ...|..|....|   ||  |  ||||||||   .|.|||.| || 
qitqvygfydeclrkygn...anvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd..drggwgisprga

SFTYGKSVVEEFCAKNDIALVIRGHQLFKEMYPqgcvLRFGGRLISLFSALNYEGHKNN-SSVL
 .|.|| . |.|  .|.. |..| |||  | |       .  .....||| ||     | ...|
gytfgkdisekfnktngltliarahqlvmegyn....wshdrnvvtifsapnycyrcgnqaail
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 47-311 6e-73 238.4 In-house 6-261 (280) alignment 
Range on Protein: 47-311
Range on HMM: 6-261/280.0
ITISEISQLTDKMKKAFLEQPALLEIsNEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDV
|   .| .. .| || .. | ...|. . |..|. |.|||   |||.|     ||.|.|||||||||||.| . |..||.. | |||.. ..|||||| .
ikeadidrviekckkiltaqatmvev.dapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevi

NTTLNYGFYDECLEQwkndEGEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLLWSDPAQpERNGWGLSHRGI
.   .|||.||. ..      ....  | . .. .||.|...|...| |||.|. | ||.|.. . ||.  .   || ||||.||.. .  ||. . ||.
sinrkygfkdevkrr....yslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpen.kvtgwaensrgv

SFTYGKSVVEEFCAKNDIALVIRGHQLFKEMYPqgcvLRFGGRLISLFSALNYEGHKNN-SSVLKL
|  .|. || ... | || |..||||. .. |     .  . .|...||| .| |. .| ..||..
svifganvvkdltekldidliarghqvvqdgye....ffadkklvtvfsapkylgefdnsaavliv
subfamily_PPP4C_pd Subfamily PPP4C 47-312 1.7e-72 237.1 In-house 16-272 (288) alignment 
Range on Protein: 47-312
Range on HMM: 16-272/288.0
ITISEISQLTDKMKKAFLEQPALLEIsNEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDV
|. .|. .|  |... ..|.  . .. . |.||  |.|||   ||..|  .   |...||||||.||||  ||  . || ..| |||... |.|||||  
ikeeevkalcakareilveesnvqrv.dspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesr

NTTLNYGFYDECLEQWKNdegEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLLWSDPAqpERNGWGLSHRGI
. |  ||||||||... .    .|||.  . |. ..|||.| ||.|| |||.|| ...|..| ||.|   ||  |  ||||||||   . .||..| || 
qitqvygfydeclrkygs...anvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpe..daegwavsprga

SFTYGKSVVEEFCAKNDIALVIRGHQLFKEMYpqgcVLRFGGRLISLFSALNYEGHK-NNSSVLKLE
 . .|..|||.|...||| |..| |||  | |     |.|  ......|| ||     | ...|.|.
gylfgsdvveqfneandielicrahqlvmegy....klhfnekvltvwsapnycyrcgnvaaileld
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 43-312 4.5e-71 232.4 In-house 4-264 (281) alignment 
Range on Protein: 43-312
Range on HMM: 4-264/281.0
LRVDITISEISQLTDKMKKAFLEQPALLEIsNEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGN
 .|..|  || ..  ...  | |. || || ..||.|| |.|.|   | |.|   . .|.....||||||||| ||. |. |||..| ||.....|||||
hkvqytkeeienvireveaifseekaLvei.dkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgn

HEDVNTTLNYGFYDECLEqwknDEGEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLLWSDPAqPERNGWGLS
||  .    |||| ||        ||..|  |   || .|..| |  .| |.|||.|| | .|...  . .|.  .  ||  ||||.||  .. ..|  |
heiasvnkiygfyvecvt....kyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpd.nkveewkas

HRGISFTYGKSVVEEFCAKNDIALVIRGHQLFKEmypqGCVLRFGGRLISLFSALNYE-GHKNNSSVLKLE
 ||.|||.||.||.. | . .. |.||.||.  .    |  .  | .||..||. ||   .|| ..|||..
srGssftfGknvvddvckrleveliirahqvvqd....Gyevlsgrklitvfsvpnycafyknaaavlkvd
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 43-308 4.8e-71 232.4 In-house 20-276 (299) alignment 
Range on Protein: 43-308
Range on HMM: 20-276/299.0
LRVDITISEISQLTDKMKKAFLEQPALLEIsNEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGN
|   .   |. .| .  |..|..|..|||. . || |. |.|||   |||||  .. ||. ..|||||||||| | . ...||.|.| .||.. |.||||
ltksvkeqelqtlcavaksvfasqasllev.eapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgn

HEDVNTTLNYGFYDECLEQWKNdegEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLLWSDPAQPeRNGWGLS
||       ||||.|| ...|     ..| .| |.|. |||. .||....| |||.|| |..|. .  . ||   |   |  ||||.|| |    .|   
hecpainrvygfyeecnkryks...trlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqs.vkdwlan

HRGISFTYGKSVVEEFCAKNDIALVIRGHQLFKEMYPqgcvLRFGGRLISLFSALNYEGHKNNSSV
 ||.|. .|. ||.. . . || || | ||. .. |     .    .|...|||  | |  .||. 
vrgvsyvfgqdvvadvisrldidlvarahqvvqdgye....ffaskklvtifsaphycgqfdnsaa
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 49-309 8e-71 231.3 In-house 12-265 (287) alignment 
Range on Protein: 49-309
Range on HMM: 12-265/287.0
ISEISQLTDKMKKAFLEQPALLEISnEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDVNT
 ..| .. .|... .   |||||.  .|||.| |.|||   |||||    |.|. .|||||||||||..|. |. |||..| .||..| |||||||  . 
dkdilevlekieeileplpalleve.apitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkki

TLNYGFYDECLEQWKndegEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPY--GLACDLLWSDPAQPeRNGWGL-SHRG
  .|||..|   . .    |.... | | |. .|| | .. ...| |||||| |.||........| .      ||  ||||.|| .   ..  |   |.
nklyGfkeelkrkrq....erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd.aktfelnkira

ISFTYGKSVVEEFCAKNDIALVIRGHQLFKEmypqGCVLRFGGRLISLFSALNYEGHKNNSSVL
||  .||..|.... | || |..| |.. .|    |  . |  ||...|||  | |.. | . .
isvvfGkkevddllkkldidlivrahevsee....Gyaflfdkrlvtvfsapyysgedtnlgav
subfamily_PPG1_pd Subfamily PPG1 50-311 5.6e-66 215.8 In-house 17-282 (300) alignment 
Range on Protein: 50-311
Range on HMM: 17-282/300.0
SEISQLTDKMKKAFLEQPALLEISnEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDVNTT
. . .||||.|. ....  . ||   |.||| |.|||   .| ||      |. .|||||||||||  ||  . || ..| |||  . |||||||  . |
vtvkeltdklkellvkesnvieir.spvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqit

LNYGFYDECLEQWKNDegEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLLWSDPA--------QPERNG--W
  |||| |||...  .   .||. . . |. . |||.|  ...| |||.||   |...|. ..|   ||  |  .|||||||         .|.|.|  .
qvygfyteclrkyggn..srvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhf

GLSHRGISFTYGKSVVEEFCAKNDIALVIRGHQLFKEMYpqgcVLRFGGRLISLFSALNYEGH-KNNSSVLKL
  |.||  ..|||.|||.|  .||.  .|| ||| .| |     . | ..| ...|| ||     | .|.|.|
vvsqrgagysygkdvvekflrnndmnriirahqlcnegy....qilfdnklstvwsapnycyrcgnkasilel
subfamily_PPP6C_pd Subfamily PPP6C 47-312 8.8e-66 215.0 In-house 15-271 (290) alignment 
Range on Protein: 47-312
Range on HMM: 15-271/290.0
ITISEISQLTDKMKKAFLEQPALLEISnEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDV
.. ... .| |.... .||. ..  .|  |.||. |.|||   |. .| |    |...|.||||.||||  |.  . .|...| .||... |||||||  
lpendlkklcdlvldllleesnvqpvs.spvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

NTTLNYGFYDECLEQWKNDegeKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLLWSDPaqPERNGWGLSHRGI
. |  ||||||||... |    ..|. ... |. ...||.| ..|.| |||.|| .. |..|. |||   .|  |  |||.||||   . . | .| || 
qitqvygfydeclnkygna...nawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp..edvetwavsprga

SFTYGKSVVEEFCAKNDIALVIRGHQLFKEmypqGCVLRFGGRLISLFSALNYEGHK-NNSSVLKLE
 . .|..|..||.. |.. |..| ||| .|    |    |  .|....|| ||     | .|.|.||
gylfgskvtkefvhinnlklicrahqlvee....glkymfdeklvtvwsapnycyrcgnvasilale
PPP_5_Dcr2 77-273 1.4e-65 214.0 In-house 1-198 (199) alignment 
Range on Protein: 77-273
Range on HMM: 1-198/199.0
ITVVADMHGQSIHLLRIFLTNE-APP-NQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDVNTTLNYGFYDECLEQWkndEGEKVWRMF
.||..|.|||   || |.. .   |. ...|.|||||||||..|. |..||...| .||..|.|||||||| .... |||..|.|...   .|.|.....
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlsky...hgkkiykil

IDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVP-PYGLACDL-LWSDPAqPERNG-WGLSHRGISFTYGKSVVEEFCAKNDIALVIRGH
 |.|...||||.| .||...|||.||...|.|... |||. ..|   |  .|| |||||. .. .| .  | ||.....|..|.|.|. ||.. |.||.|
sdvfdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdpr.daqegcklnseRGagllfgpdvtekfleknnlkliirsh

QL
.|
el
PPP_4 77-273 3.5e-65 212.7 In-house 1-196 (197) alignment 
Range on Protein: 77-273
Range on HMM: 1-196/197.0
ITVVADMHGQSIHLLRIFLTNE-APP-NQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDVNTTLNYGFYDECLEQwkndEGEKVWRMF
.||| |.|||   || ..| |   |. ...|.|||||||||..|. |..||...| .||..|.|||||||. ...| |||..|.||.    .|.......
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek....hgkeilkkl

IDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVP-PYGLACDL-LWSDPAqPERNGWGLSHRGISFTYGKSVVEEFCAKNDIALVIRGHQ
 |.|...||||.| .||...|||.|. ||||..|. |||. ..|   ....|| |||||. .. .|.  | ||.....|..|.|.|. ||.. |.||.|.
qdvfdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpr.eaqeglansvrGagllFgpdvtekfleknnlkliirshe

L
|
l
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 50-309 6.3e-65 212.1 In-house 19-272 (290) alignment 
Range on Protein: 50-309
Range on HMM: 19-272/290.0
SEISQLTDKMKKAFLEQPALLEISnEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDVNTT
..| .. .|... .   |||||.  .||..| |.|||   ||| |     ||. |.||||||||||..|. |  ||||.| ||...| |||||||  .  
kdileilekieeileplpalleve.apivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvn

LNYGFYDECLEQwkndEGEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVP--PYGLACDLLWSDPAQPERNGWGLS-HRGI
  |||..|   .     | ..|... | |. ..| | .| |..| |||||. .|| | ......| |      ||  ||||.||..   .   |  .|.|
rlygfkeelark....rgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqrai

SFTYGKSVVEEFCAKNDIALVIRGHqlfkEMYPQGCVLRFGGRLISLFSALNYEGHKNNSSVL
|  .||....... |  . |..| |    |.  .|  . |  .|...|||  | |.. |   .
svvfgkkglddllkklalslivrah....evkeegfnflfdkklvtvfsapyysgndtnlgai
PPP_2 77-273 2e-64 209.9 In-house 1-197 (198) alignment 
Range on Protein: 77-273
Range on HMM: 1-197/198.0
ITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDVNTTLNYGFYDECLeqwKNDEGEKVWRMFID
.||. |.|||   ||..| .   .|..||||||||||||..|. |..||...| .||..|.|||||||. . .  |||..|.|   |.  |.||.... .
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevl...kkkggkkvykklqe

TFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLL----WSDPAQpERNGWGLSHRGISFTYGKSVVEEFCAKNDIALVIRGHQ
.|...||||.| .||...|||.|. ...|..|...||. ..|  |. .|||    .|||.. .....  |.||.....|..|.||.. ||.. |.|| |.
vfelLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpke.keellansarGagllfgpdvteelleknklkliiRaHe

L
.
v
subfamily_PPP3C_pd Subfamily PPP3C 49-322 3.4e-64 210.3 In-house 43-318 (452) alignment 
Range on Protein: 49-322
Range on HMM: 43-318/452.0
ISEISQLTDKMKKAFLEQPALLEISnEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDVNT
 ... .. ..  | . ....|||..  ||||. |.||| . ||..|  .  | ..||||||||||||. |. ..  |...|  ||...||||||||    
eeaalkiieeaakllkkektlleve.aPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhl

TLNYGFYDECLEQWkndeGEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLLWSDPAQPERNGW------GLS
|  . | .||  ..    .|.|. .....|...||||.. .. .| |||.|| ..||.||....|   .| .|. ||||||||..   .          |
teyftfkeeckiky....seevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpns

HRGISFTYGKSVVEEFCAKNDIALVIRGHQLFKE---MYPQGCVLRFGgRLISLFSALNYEGHKNN-SSVLKLEfvGQRVKVKQ
 || |. |. . | ||  |||.  .|| |.  ..   || .  .. |   ||.|||| || .  || ..|||.|   . ....|
vrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfP.slitlfsapnyldvynnkaavlkye..nnvmnirq
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 50-309 6.9e-61 199.2 In-house 11-267 (284) alignment 
Range on Protein: 50-309
Range on HMM: 11-267/284.0
SEISQLTDKMKKAFLEQPALLEIsNEPITVVADMHGQSIHLLRIFLTNEAP------PNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNH
 |. .|  . ...| ...  ||| . |...| |.|||   || ..  |  |       ..||||||||||||  |. |. |||..| ..|..||||||||
kelielcyrarelfwkeklklei.eapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnh

EDVNTTLNYGFYDECLEQWKndegEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLLWSDPAQpERNGWGLSH
|      .|||| ||  ..     |... .|  .||.|||.||.. |..| |||||  | .|.... .|||. .|  |. .|| |.|| . | .|.  |.
esrpvnmqygfyleckkrys....ealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpea.evegykesp

RGISFTYGKSVVEEFCAKNDIALVIRGHQLFKEMYPqgcvLRFGGRLISLFSALNYEGHKNNS-SVL
||   ..|.. |.||. | .. ||.| ||. .. |     .    .|...|||  | |. .|  .||
rgagkvfgakavkeflkkfkldlvvrahqvvmdgye....ffadrklvtifsapsycgqldniaavl
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 47-316 1.1e-59 195.1 In-house 6-291 (302) alignment 
Range on Protein: 47-316
Range on HMM: 6-291/302.0
ITISEISQLTDKMKKAFLEQPALLEISNePITVVADMHGQSIHLLRIFLTNEAP-----------PNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQH
 . ||. .| ... ... .. .| |||  |.|.| |.|||   |.||....               ..|..||||||||||.|.  .||.|..|  ||..
ysksellllieaviellkkektlaeisp.PvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

VFLLRGNHEDVNTTLNYGFYDECLEQWKNDEGEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLV-VPPYGLACDLLWSDPAQP
  |||||||       ||| .|  ..  . .| ..|. | ..|  |||||..| |..| |||||| |||||||..|.|||  | .  || |||..||.. 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

E-------RNGW-GLSHRGISFTYGKSVVEEFCAKNDIALVIRGHQlfkeMYPQGCVLRFGGRLISLFSALNYEGHK-NNSSVLKLEFVGQ
.       .  .     ||.|... .. |...| . .. |..|.||    | |.|  .    .|...||| .|     |. .|||..  |.
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahq....miPeGfkffadkklltifsaprymnesdnkGavlkvdtngk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 102-309 1.3e-59 194.9 In-house 100-299 (317) alignment 
Range on Protein: 102-309
Range on HMM: 100-299/317.0
NQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDVNTTLNYGFYDECLEQWKndegEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPW
..||||||||||||  |. |. |||..| .||..|||||||||  .   .|||| |. ....    .... .|  .||..||.||.. |..| |||||  
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrys....aalyeafqlafnvlplcavvnkkilcmhGGisee

LESLEDINSIERPLVVPPYGLACDLLWSDPAqPERNGWGLSHRGISFTYGKSVVEEFCAKNDIALVIRGHQLFKEMYPqgcvLRFGGRLISLFSALNYEG
| .|. .. ..||| .|  |. .|| |.||  .| .|.  | || .. .|.. |.||. | |. ||.|.||. .. |     .  . .|...||| .| |
lldlkqldklkrpldipdvGvladltwadpd.aevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGye....ffadrklvtifsapsycG

HKNNSS-VL
...| . ||
qldniaavl
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 47-316 1.7e-59 194.4 In-house 7-292 (302) alignment 
Range on Protein: 47-316
Range on HMM: 7-292/302.0
ITISEISQLTDKMKKAFLEQPALLEISNePITVVADMHGQSIHLLRIFLTNEAP-----------PNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQH
 . ||. .| ... ... .. .| |||  |.|.| |.|||   |.||....               ..|..||||||||||.|.  .||.|..|  ||..
ysksellllieaviellkkektlaeisp.PvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

VFLLRGNHEDVNTTLNYGFYDECLEQWKNDEGEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLV-VPPYGLACDLLWSDPAQP
  |||||||       ||| .|  ..  . .| ..|. | ..|  |||||..| |..| |||||| |||||||..|.|||  | .  || |||..||.. 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

E-------RNGW-GLSHRGISFTYGKSVVEEFCAKNDIALVIRGHQlfkeMYPQGCVLRFGGRLISLFSALNYEGHK-NNSSVLKLEFVGQ
.       .  .     ||.|... .. |...| . .. |..|.||    | |.|  .    .|...||| .|     |. .|||..  |.
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahq....miPeGfkffadkklltifsaprymnesdnkGavlkvdtngk
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 50-309 2e-59 194.3 In-house 9-259 (280) alignment 
Range on Protein: 50-309
Range on HMM: 9-259/280.0
SEISQLTDKMKKAFLEQPALLEiSNEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDVNTT
 ||  .   ..  |.|.  | | .. || |..|.| |   . |.|      |..| .||||||||| | . |. ||||.| || ....|||||||  .  
heiiaiirmveaifmeesnlce.aeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvn

LNYGFYDECleQWKNdeGEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLLWSDPAQpERNGWGLSHRGISFT
  |||| ||  |.|   |  .|  |   || ||....|  .|.| |||.|| |  |. |  | ||      ||  |||||||.. . .||  | ||||. 
kiygfyvec..qyky..gvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptn.kgegwfhsirgisym

YGKSVVEEFCAKNDIALVIRGHQLFKEMYpqgcVLRFGGRLISLFSALNYEGHKNNSSV-L
.|| |||. |   .| |.||.||. .. |     .  | |||..||  ||  .  |..  .
fgkgvveqacksleidliirahqvvqdgy....emmagrrlitvfsvpnycaqftnaaavv
subfamily_PPP5C_pd Subfamily PPP5C 54-320 5.2e-59 192.8 In-house 41-303 (322) alignment 
Range on Protein: 54-320
Range on HMM: 41-303/322.0
QLTDKMKKAFLEQPALLEISN---EPITVVADMHGQSIHLLRIFLTNEAPP-NQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDVNTT
..  ..|. . ..|.|.||..   . .||  |.|||   || ||  |  |  .. ||| ||.||||| || |. .|...|  ||.|.|| |||||  |  
killeakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmn

LNYGFYDECLEQWKndegEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPW-LESLEDINSIERPLVVPPYGLACDLLWSDPAqpERNGWGLSHRGISF
  ||| .|. ....    |||  .| ..|| .||| ||  ||.  |||.      .|.|.  |.|    |  || ..||||||   |.|| . |.||...
klyGfegevkakyt....ekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpq..eanGrspskrGvgv

TYGKSVVEEFCAKNDIALVIRGHqlfkEMYPQGCVLRFGGRLISLFSALNYEGHKNN-SSVLKLEFVGQRVKV
..|  | ..|. .|.. |.|| |    |.  .|  ..  |.||..||| ||  ...| .....|.   ...|.
qfGpdvtkkflkennleliirsh....evkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkf
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 55-328 3.4e-57 187.0 In-house 11-274 (284) alignment 
Range on Protein: 55-328
Range on HMM: 11-274/284.0
LTDKMKKAFLEQPALLEIsNEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDVNTTLNYGF
|  .  . | .|| |.|. | || .. |.|||   |||.|  |  |   .||||||||||| . .  . |||. |  .|.|.|.||||||       |||
llfhafsifnkqpmliev.nspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygf

YDECLEQWKNdegEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVP-PYGLACDLLWSDPAQPeRNGWGLSHRGISFTYGKS
|.||  ....     |.  |   |  |||.|..| ...| |||.|  |. . .. .|.||.  | |  || |.|||||..  ..||    ||.|. .|  
yeecqrrynk...psvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnf.qkgwnpnsrgvsyvfgsd

VVEEFCAKNDIALVIRGHQLFKEMYPqgcvLRFGGRLISLFSALNYEGHKNNSSVLKleFVGQRVKVKQVLYRCR
 . ..  . .| ||.| ||. .. |     .    ||...|||  | |. .|.. .   .| . . .  |. | |
alrklldrlqidlvvrahqvvqdgye....ffanrrlvtifsapfycgqfdnaaavm..yvnknlvcsfvvlrpr
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 45-312 5.2e-55 179.8 In-house 18-279 (307) alignment 
Range on Protein: 45-312
Range on HMM: 18-279/307.0
VDITISEISQLTDKMKKAFLEQPALLEIsNEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHE
.. |  |. ..  . .  |  . ||..| . |  || |.|||   |. .|.    ||.  |.| |||||||  |. .. |||..|  ||... |||||||
iqytkeefenviyeaqtifssekalvdi.dppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnhe

DVNTTLNYGFYDECLEQWKnDEGEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVVPPYGLACDLLWSDPaQPERNGWGLSHR
 .    .||||.||.       ||..| .|   || .|..|.|  |..| |||.|| |  |...    .|.  |  |.  |.||.|| .|    |  | |
iarvnkkygfyeecvtsip.kcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadp.dpsvfewkassr

GISFTYGKSVVEEFCAKNDIALVIRGHQLFKEMYpqgcVLRFGGRLISLFSALNYE-GHKNNSSVLKLE
|  ||.|  |... | .  . |.|| ||.  . |     .  | .||..|||  |   .||   |||..
gsgftfgtnviddvckrlgveliirahqmcfdgy....wvlsgrklitifsapmycnfyknagcvlkvd
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 68-303 6.1e-54 176.4 In-house 1-233 (263) alignment 
Range on Protein: 68-303
Range on HMM: 1-233/263.0
ALLEIsNEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDVNTTLNYGFYDECLEQWKNDE-
||||. . || .. | |||   ||||| .  |  . .||||||||||| .|. |. ||| .|   |....|||||||      ||||. |  .... .| 
allel.qapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreev

GEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDINSIERPLVV-PPYGLACDLLWSDPAQPERNGWGLSHRGISFTYGKSVVEEFCAKNDIA
 | |.  | . |. |||.|..  ...| |||||| |.||.|| .|  ||     . |||||||.|| .  .       | ||  .||  |...| . || 
yesvynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldid

LVIRGHQLFKEMYpqgcVLRFGGRLISLFSALNYEGHK
|..| ||. .  |     .    |||..|||  |.   
livrahqvveygy....affadrrlitvfsasryqiel
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 45-307 2.3e-50 164.6 In-house 21-276 (297) alignment 
Range on Protein: 45-307
Range on HMM: 21-276/297.0
VDITISEISQLTDKMKKAFLEQPALLEIsNEPITVVADMHGQSIHLLRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHE
  ||   . .| |   . |  | ...|. | || |. |.|||   |||.|     ||  .|||||||||||  |.  . ||.. | ..|  .||||||||
kviteervlklldlaldvfkaqksmvev.napikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhe

DVNTTLNYGFYDECLEQWKndeGEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWL---ESLEDINSIERPLVvPPYGLACDLLWSDPAQpERNGWGL
       ||||.|| ....     ...  | | || .||. .|  |..| |||.|| |    .|. .. |||.      .| .||||.||      |.  
cefvnkvygfyeecqkryq...svrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierste.gkerlvadllwadpis.glsgfme

SHRGISFTYGKSVVEEFCAKNDIALVIRGHQLFKEMYPqgcvLRFGGRLISLFSALNYEGHKNNSS
 .||    .|.  | . |.. .. || | ||. .. |     .  | .|...|||  | |. .| .
nqrgagcgfgrdavlklcsefkldlvcrahqvvqdgye....ffagrklvtifsaphycgqfdnca
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 103-309 2.6e-48 157.8 In-house 120-317 (339) alignment 
Range on Protein: 103-309
Range on HMM: 120-317/339.0
QKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDVNTTLNYGFYDECleQWKNDegEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWL
..|||||||||||  |. |. || ..|  ||....|||||||       |||| |   ... |   ...  | . || .|..|||   ..| |||||  |
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrev..nyryd..aqlyecfqnmfnvfpfcavinntimcmhggisehl

ESLEDINSIERPLVVPPYGLACDLLWSDPaQPERNGWGLSHRGISFTYGKSVVEEFCAKNDIALVIRGHQLFKEMYpqgcVLRFGGRLISLFSALNYEGH
 |....  ..||| .|  |.  || |.|| .|  .|.  | || || .|   .  |  | |. .||||||. .. |     .  | ||...||| || |.
tsfnqfsvfkrpleipdvgvltdltwadp.dptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgy....effdgrrlvtifsapnycgq

KNNSSVL
..|.. .
ndntaav
Metallophos Calcineurin-like phosphoesterase 76-272 1.1e-40 133.1 Pfam-A 2-197 (200) alignment 
Range on Protein: 76-272
Range on HMM: 2-197/200.0
PITVVADMHGQSIHL----LRIFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLL--FCMKHRYPQHVFLLRGNHEDVNTTLNYGFYDECLEQ--------
.|.|..|.||.  .|    |...  .. .... .|||||.||||  |  . .||  .. |...| .|||||||||. . .  |||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

----------------------WKNDEGEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLESLEDInsierplvvppyglacdllwsdpaqperngw
                      .. . | ...... ..|...||.| ..||....||..|. ..| .||                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

glshrgISFTYGKSVVEEFCAKNDIALVIRGHQ
       |. .|. ..|... |... ||.|||.
......gselfgpdalekllekygvdlvlrGHt
subfamily_PPPLV_pd Subfamily PPPLV 55-309 3.8e-40 131.0 In-house 5-273 (290) alignment 
Range on Protein: 55-309
Range on HMM: 5-273/290.0
LTDKMKKAFLEQPALLEISnEPITVVADMHGQSIHLLR----IFLTNEAPPNQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDVNTTL
| |.  . ....  |||.   |. |. |.||.   |      .. |       ..||||||||||  || ... |. .|  || .|.|||||||    . 
lcdvavdilaaeerllelk.sptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

NYGFYDECLEQWKNDEgEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWLE------SLEDI-NSIERPLVVPPygLACDLLWSDPAQPE--------
.. .. |.  .. ..  |.||  | ..|. .||||||  ||||.|.||           ...|| . .. ..   |  || |.||||||. .        
sieykgegsfkfgdsl.eevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgap..laldilwsdpaedrdlslrgel

--RNGWGL-SHRGISFTYGKSVVEEFCAKNDIALVIRGHQLFKemypQGCVLRFGGRLISLFSALNYEGHKNNSSVL
   .|.   ..|| .  ...  .| |  .|..  |.| |.  .    .|  |. .|||. .||. .| |  |.....
vlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevke....kGirlqqkgrlltvfsssrycGssneaali
subfamily_PPP7C_pd Subfamily PPP7C 59-214 2.1e-35 115.1 In-house 45-202 (383) alignment 
Range on Protein: 59-214
Range on HMM: 45-202/383.0
MKKAFLEQPALLEIS---NEPITVVADMHGQSIHLLRIFLTNEAPP-NQKYLFLGDYVDRGSQSVVVMCLLFCMKHRYPQHVFLLRGNHEDVNTTLNYGF
 || . . | . ..|    . .||  |.||.   || |.  |  |  .. |.| ||.||||..|| ....|...   ||..|.| ||||||    | |||
akkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGf

YDECLEQWKNdEGEKVWRMFIDTFNCMPLAAVIGGKVFCAHGGISPWlESLEDINSIERP
  |  ...|. .|.|. |.. | |  .|||..|  |.. .|||||    .|| ...||| 
ikeveskykv.hgkkilrlledvfawlplatlidekilivhGGisdk.tdlelldkiers
subfamily_PPP7C_pd Subfamily PPP7C 224-311 9.4e-09 27.4 In-house 238-321 (383) alignment 
Range on Protein: 224-311
Range on HMM: 238-321/383.0
CDLLWSDPAQpERNGWGLSHRGISFTYGKSVVEEFCAKNDIALVIRGHqlfkEMYPQGCVLRFGGRLISLFSALNYEG-HKNNSSVLKL
 |.||||| . ..  .  . ||    .|  | ... .| .. |.|| |    |  |.|  .    .....||| ||     |  . .||
ldilwsdpka.keGckpntlrGgGsyfGpdvtkkllqkynlkllirsh....eckpeGyefvhdkkvltifsasnyyeeGsnrGayvkl