Gene Y18H1A.4 in Caenorhabditis elegans

Synonym: CELE_Y18H1A.4, Y18H1A.4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily CeleHP1-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP209_AA protein Get Run
CeleP209_AA_3-216 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_STS_pd Subfamily STS 7-217 4e-55 178.9 In-house 1-240 (245) alignment 
Range on Protein: 7-217
Range on HMM: 1-240/245.0
RKIWIVRHAEREDNINRNW---------------------RKLDGADGLTSDNSmLSVRGRQQAKECKNRF--ENAQISHTFASPFDRTIETASTIIEDK
|.|.||||.||.|.....|                     |. ||.....||.. |. || .|||......  ....|.|.|.||. |.|.||..|... 
rtiyivRhgeRvdevfgkWlksfdegkyerkdlnlpkelprrpdglkdyksDpP.lterGviqAkllgraLleagikiehifcSPslrciqTaaailkgl

G--MKVKADGGLCEALYLCDKP-PGFWETDKLAEKFPLVDLDYIPVFSKYTLPReGCGDDACVPRVGKTLRAIFEKY--EGNLLLVGHGASIGACHEVLM
|  .|.| . ||.|.|.|..|| | ......|...|| .|.|| ||.|...| . .. ..... |. |....|.||.  .||.|.|.|.|.. |... |.
gkkikikvepgllewlkldrkpipellspeelkkffpqidedYkpvlslselks.keseeelyeRikkvvkeiiekvpedgniliVahaatldalsrqll

GDFkYVGQATVSEFEETAP----GKYRHNYSSDSSHLSDKKNL
|   .  ....... ...|     |...|.......|.|...|
gls.presedlkklvikspycslakleenkeerkwkltdsgil
0043909 Phosphoglycerate mutase-like 6-215 4.3e-28 90.8 In-house 2-244 (249) alignment 
Range on Protein: 6-215
Range on HMM: 2-244/249.0
PRKIWIVRHAEREDNINRNWRKldgadglTSDnSMLSVRGRQQAKECKNRFE--NAQISHTFASPFDRTIETASTIIEDKG---MKVKADGGLCEA----
......|||.| |.| .. .          .| | |. .||.||... ...   . .... ..||. |.|.||  | |  |   ..|. | .| |     
mkrlyLvRHGetewnaegrfqg.......wlD.spLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGa

---------------------LYLCDKPPGFWETDKLAEKFPLVDLDYIPVFSKYTLPREGCGDDACVPRVGKTLRAIFEKY---EGNLLLVGHGASIGA
                      . .| .| ..|.. .   . |.|. ...... .  | .|    ..| || ..|. .....   .||.|.|.||... |
legltkaeiaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlra

CHEVLMG-DFK-----YVGQATVSEFEETAPGK--YRHNYSSDSSHLSDKK
.   |.| ..      ........ .| .. ||  ... . .| |||....
llayllglsledilrlnlpngsitvlelddggkpvvvlvllndtshleall
0039931 Phosphoglycerate mutase-like 8-216 9.8e-27 86.2 In-house 1-196 (219) alignment 
Range on Protein: 8-216
Range on HMM: 1-196/219.0
KIWIVRHAEREDNINRNWRKldgadgltsdNSMLSVRGRQQAKECKNRFEN--AQISHTFASPFDRTIETASTIiedkGMKVKADGGLCEalylcdKPPG
....|||.| |.| .. .            .| |. |||.||... .|. .   .. . ..||. |.|.||  |    |..|. | .|.|         |
rlyLvRHGetewnvegrlqg..........dspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii....glpveidprLrE......idfg

FWETDKLAEKFPLVDLDYIPVFSK--YTLPREGCGDDACVPRVGKTLRAIFEkyEGNLLLVGHGASIGACHEVLMG------DFKYVGQATVSEFEETAp
 .|   |.|   ... ..   .    .. | .|    ..| || . |.....  ..|.|.|.||..| |    |.|         ......|...| .. 
dlegltleeiaekypeelaawlrdpydyrppggEsladvvaRvlpaleella..genvlvVsHggvirallayllglsleeilrlnlpngsvtvleldd.

GKYRHNYSSDSSHLSDKKN
|...  .  . |||.| ..
ggwvlvllnltshlddllr
0036887 Phosphoglycerate mutase-like 6-211 1.2e-26 86.0 In-house 1-201 (202) alignment 
Range on Protein: 6-211
Range on HMM: 1-201/202.0
PRKIWIVRHAEREDNINRNWRKldgadgltSDNSMLSVRGRQQAKECKNRFENAQISHTFASPFDRTIETASTIIEDKGMKVKADGGLCEALYLCDkppG
......|||.|.|.|... .            .. |. .||.||... .|. . .. . ..||. |.|.||  | |  |..|. | .|.|  . .     
mtrlyLvRHGetewnvegrlqg........dldvpLtelGreqaralgerlaglpfdavysSpllRaiqTaeiiaealglpvivdprlrEidfgal...e

FWETDKLAEKFPLVDLDYIPVFSKYTLPrEGCGDDACVPRVGKTLRAIFEKY-EGNLLLVGHGASIGACHEVLMG-------DFKYVGQATVSEFEEtAP
 . .. .|||.|    ...  .  .. | .|    ..| || ..|....... .||.|.|.||... |.   |.|       ...... ..|. .|   .
gltleeiaekypeelaawlrdpydfrpp.ggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlel.dd

GKYRHNYSSDSSHL
|...  .  | |||
ggwvlvllndtshL
0035570 Phosphoglycerate mutase-like 8-215 2e-26 85.3 In-house 1-197 (219) alignment 
Range on Protein: 8-215
Range on HMM: 1-197/219.0
KIWIVRHAEREDNINRNWRKldgadgltsdNSMLSVRGRQQAKECKNRFEN--AQISHTFASPFDRTIETASTIiedkGMKVKADGGLCEALYlcdkppG
....|||.|.|.|... .            .. |. |||.||... ... .   .. . ..||. |.|.||  |    |..|. | .|.|  .      |
rlyLvRHGetewnlegrlqg..........dvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii....glpveidprLrEidf......g

FWETDKLAEKFPLVDLDYIPVF--SKYTLPREGCGDDACVPRVGKTLRAIfEKyEGNLLLVGHGASIGACHEVLMG------DFKYVGQATVSEFEETAP
 .|   |.|   . . ..  ..  . .. | .|    ..| || . |... |. ..|.|.|.||..| |   .|.|       .  .....|. .| ...
dlegltldeiaekypeelaawlrdpydyrppggEsladvvaRvlpaleel.ed.genvlvVsHggvirallayllglpleeilrlnlpngsvtvleldgg

G-KYRHNYSSDSSHLSDKK
| |... . .| |||....
ggkwvlvllndtshlelll
0036777 Phosphoglycerate mutase-like 6-214 2.1e-26 85.5 In-house 2-238 (247) alignment 
Range on Protein: 6-214
Range on HMM: 2-238/247.0
PRKIWIVRHAEREDNInrnwrkldgaDGL---TSDnSMLSVRGRQQAKECKNRFEN--AQISHTFASPFDRTIETASTIIEDKG---MKVKADGGLCEA-
......|||.| |.|.          .|.    .| . |. .||.|||..  .. .   .. . ..||. |.|.||  | |  |   ..|. | .| |  
mkrlyLvRHGetewna..........egrfqgwlD.vpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErd

------------LYLCDKPPGFWETDKLAEKFPLVDLDYIPVFSKYTLP--------REGCGDDACVPRVGKTLRAIFEKY---EGNLLLVGHGASIGAC
            .   ..   .| .|..   .||..|..  ......           .|    ..| || ..|. .....   ..|.|.|.||... |.
yGalegltkaeiaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlral

HEVLMG------DFKYVGQATVSEFEETAPGK-YRHNYSSDSSHLSDK
  .|.|         ... .... .| ...|| ... .  | |||...
layllglsledilrlnlpngsitvleldddgklwvleslndtshlelg
0051064 Phosphoglycerate mutase-like 6-213 2.7e-25 82.1 In-house 3-238 (241) alignment 
Range on Protein: 6-213
Range on HMM: 3-238/241.0
PRKIWIVRHAEREDNINRNWRKldgadglTSDnSMLSVRGRQQAKECKNRFEN--AQISHTFASPFDRTIETASTIIEDKG---MKVKADGGLCEALYLC
......|||.|.|.| .. .          .| . |. .||.||... .|. .   .... ..||. |.|.||  | |  |   ..|. | .| |  . .
mkrlyLvRHGesewnaegrlqg.......wtD.vpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfga

DKP-------------PGFWETDKLAEKFPLVDLDYIPVFSKYTLP--------REGCGDDACVPRVGKTLRAIFEK---YEGNLLLVGHGASIGACHEV
.                 .| .|.|   .||..|. . ..   ..           |   .... || . |. ....    ..|.|.|.||..| |.  .
legltleeiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallay

LMG-------DFKyVGQATVSEFEETAPG-KYRHNYSSDSSHLSD
|.|       ... .. ..|. .| .. | .... .  | |||.|
llglpleellrln.lpngsvtvleldddgkrvvlvllndtshled
0048955 Phosphoglycerate mutase-like 8-179 4.4e-24 78.1 In-house 2-194 (240) alignment 
Range on Protein: 8-179
Range on HMM: 2-194/240.0
KIWIVRHAEREDNINRNWRKldgadglTSDnSMLSVRGRQQAKECKNRFEN--AQISHTFASPFDRTIETASTIIEDKG---MKVKADGGLCEALYLCDK
....|||.|.|.| .. .          .| . |. .||.||... .|. .   .... ..||. |.|.||  | |  |   ..|  | .| |  . .. 
rlyLvRHGesewnaegrlqg.......wtD.vpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgale

PpgfWETDKLAEKFPLVdLDYIPVFSKYTLP-------------------------REGCGDDACVPRVGKTLRAIFEK---YEGNLLLVGHGASIGACH
       | .||||| . |. .   . ...|                          .|   .... || . |. ....    ..| |.|.||..| |. 
g...ltldeiaekfpee.lvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirall

EVLMG
 .|.|
ayllg
His_Phos_1 Histidine phosphatase superfamily (branch 1) 8-173 9.3e-24 77.1 Pfam-A 1-158 (158) alignment 
Range on Protein: 8-173
Range on HMM: 1-158/158.0
KIWIVRHAEREdninrnWRKLDGADGLTSdnSMLSVRGRQQAKECKNRFE--NAQISHTFASPFDRTIETASTIIEDKGMKVKADGGLCEALYlCDKpPg
....|||.|.|      |.| . ..| .   . |. .||.||.|. ....  . .|.. ..||. |.|.||  . |....... . .| |  .  .    
rlylvRHGese......wnkegrlqgwsd..vpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdf.gew.e.

FWETDKLAEKFPLVDLDYIPVFSKYTLPrEGCGDDACVPRVGKTLRAIF--EKYEGNLLLVGHGASIGAC
   .....|.||  .  ..    ... | ||   .... || ..|....  .. ..|.|.|.||... |.
glpkeevkeefpeeyekwkrdkkefrpp.egesladvyeRvapfleelieakdkgenvlivsHggvlral
His_Phos_1 Histidine phosphatase superfamily (branch 1) 8-173 9.3e-24 77.1 In-house 1-158 (158) alignment 
Range on Protein: 8-173
Range on HMM: 1-158/158.0
KIWIVRHAEREdninrnWRKLDGADGLTSdnSMLSVRGRQQAKECKNRFE--NAQISHTFASPFDRTIETASTIIEDKGMKVKADGGLCEALYlCDKpPg
....|||.|.|      |.| . ..| .   . |. .||.||.|. ....  . .|.. ..||. |.|.||  . |....... . .| |  .  .    
rlylvRHGese......wnkegrlqgwsd..vpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdf.gew.e.

FWETDKLAEKFPLVDLDYIPVFSKYTLPrEGCGDDACVPRVGKTLRAIF--EKYEGNLLLVGHGASIGAC
   .....|.||  .  ..    ... | ||   .... || ..|....  .. ..|.|.|.||... |.
glpkeevkeefpeeyekwkrdkkefrpp.egesladvyeRvapfleelieakdkgenvlivsHggvlral
0037864 Phosphoglycerate mutase-like 4-179 1.7e-23 75.6 In-house 5-176 (211) alignment 
Range on Protein: 4-179
Range on HMM: 5-176/211.0
TYPRKIWIVRHAEREDNINRNWRKldgadgltSDNSMLSVRGRQQAKECKNRFEN--AQISHTFASPFDRTIETASTIIEDKG---MKVKADGGLCEaly
........|||.|.|.|... .            .. |. .||.||... ... .   .... ..||. |.|.||  | |  |   ..|. | .| |   
llmtrlyLvRHGetewnaegrlqg........wldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrE...

lcdKPPGFWET---DKLAEKFPLVDLDYIPVFSkYTLPREGCGDDACVPRVGKTLRAIFEKY---EGNLLLVGHGASIGACHEVLMG
      | .|    . .|||.|     ..  .  .. | .|    ..| || ..|. .....   ..|.|.|.||... |.  .|.|
...rdfgalegltleeiaekypeelvawlrdpy.dfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllg
0053607 Phosphoglycerate mutase-like 6-179 4.2e-21 67.8 In-house 1-156 (191) alignment 
Range on Protein: 6-179
Range on HMM: 1-156/191.0
PRKIWIVRHAEREDNINRNWRKldgadgltsdNSMLSVRGRQQAKECKNRFE--NAQISHTFASPFDRTIETASTIiedkGMKVKADGGLCEALYlcdkp
......|||.| | | .. .            .. |. .||.||. . ...   . .. . ..||. |...||  |    |..|. | .| |  .     
mtrlyLvRHGetewnaegrlqg..........dvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii....glpvevdprlrEidf.....

pGFWETDK---LAEKFPLVDLDYIPVFSKYTLPrEGCGDDACVPRVGKTLRAIFEkyEGNLLLVGHGASIGACHEVLMG
 | ||      ||||.| .   ..     |. | .|   .... || ..|. ...  .||.|.|.||..| |    |.|
.gdwegltleelaekypeelaawlrdpldyrpp.ggEsladvaaRvlpaleella..ggnvlvVaHggvirallayllg
0049178 Phosphoglycerate mutase-like 6-210 1.1e-19 63.6 In-house 3-231 (243) alignment 
Range on Protein: 6-210
Range on HMM: 3-231/243.0
PRKIWIVRHAEREDNINRNWRKldgadglTSDnSMLSVRGRQQAKECKNRFE--NAQISHTFASPFDRTIETASTIIEDKG---MKVKADGGLCEALYlc
......|||.| | |  . .          .| | |. .||.||... ...   . .. . ..||  |.|.||  | |  |   ..|. | .| |  .  
mtrlyLvRHGetewnaegrlqg.......wtD.spLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdf..

dkppGFWETDKLAEKFP-------------------------LVDLDYIPVFSKYTLPREGCGDDACVPRVGKTLRAIFEK---YEGNLLLVGHGASIGA
    | .|   .|| .                          |.   ..... .. |. .|   .... || ..|. ....    ....|.|.||..| |
....GalegltkaeiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvira

CHEVLMG-DFK-----YVGQATVSEFEETApGKYRHNYSSDSSH
    |.| ...      .. ..|...| .  |...  .  | ||
llalllglpleellrlnlpngsvtvleldd.ggwvlvslndtsh
subfamily_TFC7_pd Subfamily TFC7 8-127 4e-15 47.1 In-house 2-124 (255) alignment 
Range on Protein: 8-127
Range on HMM: 2-124/255.0
KIWIVRHAEREDNINRNWRKlDGADGLTSDNSmLSVRGRQQAKECKNRFENAQISH--TFASPFDRTIETASTIIEDKGMKVKADGGLCEAlYLCDKPPG
.|.| ||  |.. ... ..  |   |. ||   || || .||||  .  .. .. .   |.||..| .||. .|.|   . |. | |. |  |  |. | 
tiyiarhGyrsnwlpkgpyp.dpltgidsdvP.lserGveqakelaiylkkldlkpeaifssPlyrcletskpiaeeleiPvyvdrGvgew.ykpdrrPv

F---WETDKLAEKFPL-VDLDYIPVF
       . |  .||  ..||| .  
ilePasnevlskffPsvisldyestl
0050036 Phosphoglycerate mutase-like 8-179 7.3e-15 47.2 In-house 2-146 (171) alignment 
Range on Protein: 8-179
Range on HMM: 2-146/171.0
KIWIVRHAEREDNINRNWRKLdgadgltsDNSMLSVRGRQQAKECKNRFenaQISHTFASPFDRTIETASTIIedkgMKVKADGGLCEALYlcdkppGFW
....|||.| | |... .            .. |. .||.||.   ...   .. . ..||  |...||  |     ..|  | .| |  .      | |
rlyLvRHGetewnlegrfqgw........tdvpLtelgraqaralgell...pfdavysSpllRArqTaelil....lpvivdprLrErdf......Gaw

ETDKLAEKFPLVDLdyIPVFSKYTLPREGCGDDACVPRVGKTLRAIFekyeGNLLLVGHGASIGACHEVLMG
|   |.| .  .    .     .  | .|    ... || ..|. .     ||.|.|.||..| |   .|.|
egltldeiaakype..wlldlldlappggEsladvlaRvlpaleell....gnvlvvaHggvirallalllg
subfamily_TIGAR_pd Subfamily TIGAR 9-90 1.5e-10 33.2 In-house 3-80 (222) alignment 
Range on Protein: 9-90
Range on HMM: 3-80/222.0
IWIVRHAEREDNINRNwrkldgADGLtsDNSMLSVRGRQQAKECKNRFENAQISHTFASPFDRTIETASTIIEDKG----MKVKAD
...||| | | | ..         |    .. || .|..|||   .| .|..| . |.|. .|. .||. | .       ..|. |
livVrhGetefnkeki......lqgq..tdtpLsekGveQakrvakrLsnekinyifsSdllRAkqTaeiilkalkekkreaverd
subfamily_PFKFB_pd Subfamily PFKFB 6-97 2.9e-10 31.9 In-house 6-92 (198) alignment 
Range on Protein: 6-97
Range on HMM: 6-92/198.0
PRKIWIVRHAEREDNinrnwrkldgADGLTSDNSMLSVRGRQQAKECKNRFENAQIS--HTFASPFDRTIETASTIiEDKGMKVK----ADGGLCEAL
||.|..|||.| |.|          . |  . .| |. ||...||. .. ... ...  . ..| . |||.||... . .  ..|     | | |. |
preiylvRhGesekn..........kkgriggdseLterGveyakklakfikeenlkelrvwtselkrtiqTaell.glpkeqwkaLdeldaGkcdgl
subfamily_Cele-STS-like_pd Subfamily Cele-STS-like 58-175 1.1e-06 19.1 In-house 71-185 (229) alignment 
Range on Protein: 58-175
Range on HMM: 71-185/229.0
NAQISHTFASPFDRTIETASTIIEDKG---MKVKADGGLCEALYLcdKPPGFWETDKLAEKFPlVDLDYIPVfskYTLPREGCGDDaCVPRVGKTLRAIF
 ...|. | ||  |...|| ....  |   .... . || |. .   ..  . . .  .  .| || .| |.     | ..   .|  | |. .... . 
giepsvvFCSPdlrsvqtaalllkglGlkraaisvePgLleyrka..revllppkafkklgyp.vdekYkPl...kelsmaeslsd.fvariqaafkkll

EKYEGNLLLV-GHGASIGACHE
.| | .|.||  ...|.  ...
skveqklilvvadnvsleltrr
0053031 Phosphoglycerate mutase-like 9-80 1.5e-06 21.0 In-house 7-88 (342) alignment 
Range on Protein: 9-80
Range on HMM: 7-88/342.0
IWIVRHAER--EDNINRNWRKLDGAdgltSDN-SMLSVRGRQQAKECKNRFE-----------NAQISHTFASPFDRTIETASTII
|..||| .|  ..... ....        ... ..|. .||.||.|.  |.            | .. . ..|..|||...|  ..
ivlvRHGaRtPlskgpldplnewfy....pcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqafl
0047369 Phosphoglycerate mutase-like 9-79 3.2e-06 19.7 In-house 48-144 (438) alignment 
Range on Protein: 9-79
Range on HMM: 48-144/438.0
IWIVRHAER------EDNINRNWRKLDGADGLTSDN-------------SMLSVRGRQQAKECKNRFEN-------AQISHTFASPFDRTIETASTI
....|| .|       ...  .| .|. | ...|..              .|. .||.||.|.  |. .        .. . ..|..|||...|   
qvlfRHGaRtPtksklkkleplwellenattypsgplsflndwlgpcgagqLTplGreqayelGkrlrkrYglLnpedvlyvrssdvdRtlqSAqaf