Gene Y40H4A.2 in Caenorhabditis elegans

Synonym: CELE_T16G12.7, T16G12.7

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP216_AA protein Get Run
CeleP216_AA_45-329 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP1C_pd Subfamily PPP1C 44-329 1.2e-116 381.8 In-house 6-281 (282) alignment 
Range on Protein: 44-329
Range on HMM: 6-281/282.0
VDVTVSKEEIRIISNYAAASFGSFSTLMRVDEdclPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCR
 .|.....||. ....| . . | ..|.....   ||.||||.||.. ||.|.| ..|||  |.|.|||||||||.|..||..||.||.. ||..|||.|
kevklkeaeieallkkareillsqpillelea...PvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllr

GNHEDYNTTMTYGFFDECRMKYGKKgtlAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLACDLVWSDPEKTsNVGWSL
||||.......|||.|||...|..|    | .....||.||||||. .|.||.|||.||....||.|.|||||. .|..||.|||.||||.|. ..||| 
GnhesasinriyGfydeckrrysik...lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdke.vlgwse

SARGISFSFDDITIEKFCQDNGLDLIVRAHQISSEmirgGHKWHANGRMVTIFSAANYLS-MGNDSCVIRIDEQKTMQFCLLRPVKK
..||.||.|.. ..|||.|.| |||||||||. ..    |....|. ..||.|||.||.. ..|...|...||.....|..|.|.||
ndrGvsftfgkdvvekflqkndldlivrahqvved....Gyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpakk
0045823 Metallo-dependent phosphatases 46-329 9.7e-89 291.1 In-house 41-326 (473) alignment 
Range on Protein: 46-329
Range on HMM: 41-326/473.0
VTVSKEEIRIISNYAAASFGSFSTLMRVDEdclPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGN
 ....|... . ..|.  . . ..| ...    .. ..||.||.. ||.|.. . | |.  ..|||||.|||| ...|.. ||.|. ..||.. || |||
gllpeedllklldeakeilkkepnllelsm...rivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGN

HEDYNTTMTYGFFDECRMKYGKKgtlAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLACDLVWSDPekTSNVG-----
||... .  |||.||.. ||| .    . .... ...|||||.| .|.|..|||.||... |..|..|.||  ||..||..||.||||  ..  |     
HElrllnglygfgdetlekyged...lyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP..weddgdgllr

---WSLSARGISFSFDDITIEKFCQDNGLDLIVRAHQISSEmirgGHKWHANGR------MVTIFSAANYLS-MGNDSCVIRIDEQKtMQFCLLRPVKK
   .  | ||... |.   .|.|...||||||||.|.   |    |.... .|.       .|.||| ||.  .|| ..|..|||.. ..| ...|.. 
lrffgnsprgagylFgpdaveeflkkngldlivrGHthvpe....GyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsph
PP2Ac_SM00156 49-327 5.6e-85 277.6 In-house 2-270 (271) alignment 
Range on Protein: 49-327
Range on HMM: 2-270/271.0
SKEEIRIISNYAAASFGSFSTLMRVDedcLPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHED
||||.. . . ... . . ..|..|.    || .|||.|| . || |..   | |  ..||||||||||| |.||...||.|.. |||....| |||||.
skeevlelleevkeilkqeknlvevs...apvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEs

YNTTMTYGFFDECRMKYgkkGTLAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLACDLVWSDPeKTSNVGWSLSARGI
 .....|||..|.. ||   |. ..  . .||. ||||||. .|.||||||.||....|.||.|..|.  .|  ||..||.|||| .... |.. |.||.
ssvnkiygfeeevkrky...gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdp.eqkekgfqpskrgl

SFSFDDITIEKFCQDNGLDLIVRAHQISSemirGGHKWHANGRMVTIFSAANYLS-MGNDSCVIRIDEQKTMQFCLLRPV
|. |    ...|.. | |.||.|||....     |... |....|||||| ||.. ..|  .|...... .... .|.. 
svvFgedavkeflkknnlkliiRahevvd....eGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
0049330 Metallo-dependent phosphatases 47-329 9.4e-83 270.9 In-house 29-301 (309) alignment 
Range on Protein: 47-329
Range on HMM: 29-301/309.0
TVSKEEIRIISNYAAASFGSFSTLMRVDedcLPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNH
..|.||.. . ..|   . |...|....    .....||.||.. ||.|.. . | |.  ..|||||.|||| ...|.. ||.|. .||||. ||.||||
llseeellllllkakeilksepnllels...mrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvfllrGNH

EDYNTTMTYGFFDECRMKYGKKgtlAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLACDLVWSDPEKTSNvGWSLSAR
|... .. |||.||. .||| .    | .... ...|||||.| .|.||.|||.||... |..|....||. || .|| |||.||||  . . |.  . |
Elrllnglygfgdetlrkygae...lweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpire.gfapnpr

GISFSFDDITIEKFCQDNGLDLIVRAHQIssemIRGGHKWHANGRMVTIFSAANYLS-MGNDSCVIRIDEQKTMQFCLLRPVKK
|... |.  ..|.|.. ||||||.|.|.       ||......|...|.||| ||.  .||  .|..|||.....|.|..||. 
glgvvfghtaverflkkngldliirghga....vfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpl
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 29-329 7.3e-81 264.5 In-house 8-296 (298) alignment 
Range on Protein: 29-329
Range on HMM: 8-296/298.0
SRLMTAPMKEKSpaeVDVTVSKEEIRIISNYAAASFGSFSTLMRVDEdclPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLL
...... ..||.   .  ....|..  . . |   | . ..|. ||    |... ||.|| . || |.|   | |  . |.||||||||||| .|...||
ievlsvslsekk...ltkvikeedveklielakkifkkqkslvevda...pikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivll

MAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRMKYGKKGtlAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLACDL
.||   ||...|| |||||      .|||..||. .| .     . .  ..||.|||.||| ...||||||.|.....|... ...||.  ..  || ||
laykvkypnnffllrGnheceainrvyGfyeeckrrykslr..lyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidl

VWSDPEKTsNVGWSLSARGISFSFDDITIEKFCQDNGLDLIVRAHQIssemIRGGHKWHANGRMVTIFSAANYLS-MGNDSCVIRIDEQKTMQFCLLRPV
.|.|||..   ||. ..||.|. | . ........  .||.|||||.    .. |... |. ..|||||| .|.  . | ..|...||. .. | .|.| 
lwadpena.vkgwaensrGvsvvfGedvvkdllekldidlvvrahqv....vqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpe

KK
||
kk
PPP_3 52-322 4.1e-80 261.6 In-house 6-267 (271) alignment 
Range on Protein: 52-322
Range on HMM: 6-267/271.0
EIRIISNYAAASFGSFSTLMRVDedcLPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYNT
|.. . . ..  . . |.|....    || ..||.|| . || ..| . | .  ..|.||||||||| ...|...||.|. ..||....| |||||. . 
elkelvkklkeilekesnlveis...apvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqi

TMTYGFFDECRMKYGkkGTLAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLACDLVWSDPEKTSNvGWSLSARGISFS
. .||| .|.  |.|  |.  . .. . |. ||||||| .|||..|||.||.|..|..| |..|.. .|. |. .|| .|..... . |.. |.||... 
nkvYgFkkevlkkkg..gkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekee.glenskrGagll

FDDITIEKFCQDNGLDLIVRAHQISSEmirgGHKWHANGRMVTIFSAANYLS-MGNDSCVIRIDEQKTMQFC
|     |.|...| |.||.|||.. .|    |.. ...|..||.||| ||.. ..|  ......|..|..| 
FgpdvteefleknkLkliiRaHelkee....GyeilhdgkvvtvfSapnycerasnagailkleealtsefk
0053225 Metallo-dependent phosphatases 47-327 6.1e-77 251.9 In-house 21-291 (293) alignment 
Range on Protein: 47-327
Range on HMM: 21-291/293.0
TVSKEEIRIISNYAAASFGSFSTLMRVDedcLPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNH
..|.||.. . ..|   . . ..|....    .. ..||.||.. ||.... . | |. ...|||||.|||| ...|.. ||.|. .||||. .| ||||
llseeelllllleakeilkkepnllels...mriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNH

EDYNTTMTYGFFDECRMKYGkkGTLAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLACDLVWSDPEktSNVGWSLSAR
|... .. |||.||. .|||  .   | .... ...||||||| .|.|..|||.||..  |..|..|.||. || .|| .||.||||      ||  | |
Elmllnglygfgdetlrkyg..aaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd..lwsgwlpsyr

GISFSFDDITIEKFCQDNGLDLIVRAHQIssemIRGGHKWHANGRMVTIFSAANYLS-MGNDSCVIRIDEQKTMQFCLLRPV
|... |.  ....|.. ||||||.|.||       .|.... .|..||.||| |||  .|| ..|. .||. ...|.|..||
glgvvfghtavlrflkkngldliirghqv....vpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_PPP4C_pd Subfamily PPP4C 70-325 4.4e-76 248.9 In-house 38-283 (288) alignment 
Range on Protein: 70-325
Range on HMM: 38-283/288.0
LMRVDEdclPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRMKYGKKg
. |||    || . ||.|| | ||...| . |     .|.||||.||||   .|| .||.|... |||.. | |||||  . | .|||.|||  |||.  
vqrvds...pvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitqvygfydeclrkygsa.

tLAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLACDLVWSDPEKTSnvGWSLSARGISFSFDDITIEKFCQDNGLDLI
   | .  . |..|.|||.| .|..|.|||.||.|..|..|  |.| . .|  |  |||.|||||...  ||..| ||  . | . ..|.|...|...||
.nvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae..gwavsprgagylfgsdvveqfneandieli

VRAHQISSEmirgGHKWHANGRMVTIFSAANYL-SMGNDSCVIRIDEQKTMQFCLLR
.||||.  |    |.|.| | ...|..|| ||    || . ....||.   .| .. 
crahqlvme....gyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkife
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 27-330 1.2e-73 241.0 In-house 6-297 (299) alignment 
Range on Protein: 27-330
Range on HMM: 6-297/299.0
FISRLMTAPMKEKSpaeVDVTVSKEEIRIISNYAAASFGSFSTLMRVDEdclPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVM
..|.|..  | ||.   .  .| ..|.. . . |  .| | ..|. |.    |. ..||.|| . || ||| . | |  . ..||||||||||| .|...
llskllnvgmsekr...ltksvkeqelqtlcavaksvfasqasllevea...piivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelit

LLMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRMKYgkKGTLAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLAC
||....  ||...|. |||||       |||..||  .|  | |  |. . .||. .||. ||  ..||||||.||..|.|. . ...||   |.  |  
lllcfkikyperffmlrgnhecpainrvygfyeecnkry..kstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgi

DLVWSDPEKtSNVGWSLSARGISFSFDDITIEKFCQDNGLDLIVRAHQIssemIRGGHKWHANGRMVTIFSAANYLS-MGNDSCVIRIDEQKTMQFCLLR
||.|.||.. | ..|   .||.|. | .  ... ..  ..||. ||||.    .. |... |. ..||||||  |   . | ......||.    | .|.
dllwadpdq.svkdwlanvrgvsyvfgqdvvadvisrldidlvarahqv....vqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlk

PVKKS
| .||
ptpks
PPP_1 78-307 2.7e-73 239.5 In-house 28-257 (264) alignment 
Range on Protein: 78-307
Range on HMM: 28-257/264.0
LPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRmkYGKKGTLAWLHII
 .. ..||.|| | || ..| . | .  ..|.||||||||| . .|...||.|.   ||..||| |||||. . | .||| .|..  . | ..  .  . 
eeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkvygFkkEvl..kkkyskeiyktlt

NAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLACDLV-------WSDPEKTsNVGWSLSARGISFSFDDITIEKFCQDNGLDLIV
..|. ||||||| .|.|..|||.||... |..| |..| | .|. | .|||.       .||.... . ... | ||... |    .|||.| |.|.||.
dvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeq.eeavansiRGagylfgkdvtekflqknnlklii

RAHQISSEmirgGHKWHANGRMVTIFSAANYLSMGND
|||.. .|    |.........||||||.|| . |..
RaHevkee....Gyeflkkrkvvtifsasnyyeegsn
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 45-326 2.2e-71 233.4 In-house 5-276 (281) alignment 
Range on Protein: 45-326
Range on HMM: 5-276/281.0
DVTVSKEEIRIISNYAAASFGSFSTLMRVDEdclPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRG
.| ..||||  .   . | | . ..|. .|.   |. .|||||..| ||.|.| . | .    .|||||||||| |..|...||....  |.|...| ||
kvqytkeeienvireveaifseekaLveidk...PivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrg

NHEDYNTTMTYGFFDECRMKYGKKgtlAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLACDLVWSDPEKtSNVGWSLS
|||  .    |||. || .|||..    |  . . ||.||..|||  .|||||||.|| .  |... .. .|   .  ||  ||.|.||.. .  .|  |
nheiasvnkiygfyvecvtkyGee...lwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdn.kveewkas

ARGISFSFDDITIEKFCQDNGLDLIVRAHQisseMIRGGHKWHANGRMVTIFSAANYLSM-GNDSCVIRIDEQKTMQFCLLRP
.||.|| |    ... |.  ...||.||||    ..  | .  .  ...|.||. || ..  | ..|...||.  ...  | |
srGssftfGknvvddvckrleveliirahq....vvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvp
subfamily_PPZ_pd Subfamily PPZ 28-328 3.3e-71 233.2 In-house 7-295 (300) alignment 
Range on Protein: 28-328
Range on HMM: 7-295/300.0
ISRLMTAPMKEKSPAevDVTVSKEEIRIISNYAAASFGSFSTLMRVdedCLPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVML
| .|. |    |     .| . ..||  |   |   | .  .|. .   . .|.||||.||...|| |.|   | | .. |.|||||||||.| .||..|
iqklldagyaakrtk..nvclknseilqicikarelflaqpallel...spsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletill

LMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRMKYGKKgtlAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLACD
|..|.  ||. .|| |||||  | |  |||.|||. .   |    |  ....|| |||||..  |..|.|||.|| .. ...| .. ||| .| .||  |
llcykikypenffllrgnhecanvtrvygfydeckrrcnik...iwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglind

LVWSDPEKTSNvGWSLSARGISFSFDDITIEKFCQDNGLDLIVRAHQIssemIRGGHKWHANGRMVTIFSAANYLS-MGNDSCVIRIDEQKTMQFCLLRP
|.||||  .||  |    ||.|. .. ..|.|| .  |.||..||| .    .  |...  .  .||.||| ||   . |  .|. . |     | || |
llwsdptdssn.ewednergvsycynkvainkflnkfgfdlvcrahmv....vedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp

VK
. 
ld
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 69-327 6.9e-70 228.4 In-house 27-275 (280) alignment 
Range on Protein: 69-327
Range on HMM: 27-275/280.0
TLMRVDEdclPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRMKYGKK
|.. ||    || ..||||| . || |.|   . |  . |.||||||||||| .| ..||.||.  ||..... |||||  .   .||| ||.. .| ..
tmvevda...pvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygfkdevkrrysla

gtlAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLACDLVWSDPEKTsNVGWSLSARGISFSFDDITIEKFCQDNGLDL
    . .. . ...|||.||.  ..||||||.|.... |.|. ...||   .   || ||.|.|||.    ||. ..||.|  | .  . ....   .||
...lynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenk.vtgwaensrgvsvifganvvkdltekldidl

IVRAHQIssemIRGGHKWHANGRMVTIFSAANYL-SMGNDSCVIRIDEQKTMQFCLLRPV
|.| ||.    .. |... |. ..||.||| .|| .. |...|...||.  . | .|.| 
iarghqv....vqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
subfamily_PPP6C_pd Subfamily PPP6C 77-329 4.3e-69 225.8 In-house 41-286 (290) alignment 
Range on Protein: 77-329
Range on HMM: 41-286/290.0
CLPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRMKYGKkgTLAWLHI
  || ..||.|| | ||  .|   |    ..||||||.||||   .||. .|.. .  |||.. | |||||  . |  |||.|||  |||.  . || ..
sspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygfydeclnkygn..anawkyc

INAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLACDLVWSDPEKTSNvgWSLSARGISFSFDDITIEKFCQDNGLDLIVRAHQIS
.. |. |..||.| ..|||.|||.||... |..|  |.| . ||  |  |||||||||. ..  |..| ||  . |     ..|.. | |.||.||||. 
tkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet..wavsprgagylfgskvtkefvhinnlklicrahqlv

SEmirgGHKWHANGRMVTIFSAANYL-SMGNDSCVIRIDEQKTMQFCLLRPVKK
.|    | |.. . ..||..|| ||    || ........... .. |.. |..
ee....glkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpd
subfamily_PPP2C_pd Subfamily PPP2C 72-327 2.4e-68 223.5 In-house 38-286 (290) alignment 
Range on Protein: 72-327
Range on HMM: 38-286/290.0
RVDEDCLPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRMKYGKKGtl
 | |   || ..||.|| | ||  .| | |    . |.|||||||||   .||| ||.| .  |.. . . |||||  . |  |||.|||  |||.    
nvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqitqvygfydeclrkygnan..

AWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLACDLVWSDPEktSNVGWSLSARGISFSFDDITIEKFCQDNGLDLIVR
 | .. . |..|||.||. ....|.|||.||.|. |..| ...|   .|  |  |||.||||.     ||..| ||  ..| .   ||| . ||| ||.|
vwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd..drggwgisprgagytfgkdisekfnktngltliar

AHQISSEmirgGHKWHANGRMVTIFSAANYL-SMGNDSCVIRIDEQKTMQFCLLRPV
|||.  |    |..|  . ..|||||| ||    || .... .|.. ...|    | 
ahqlvme....gynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpa
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 78-326 6.8e-68 222.2 In-house 35-282 (284) alignment 
Range on Protein: 78-326
Range on HMM: 35-282/284.0
LPVHIVGDLHGHFGDLRRIFGIHGAP------GISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRMKYGKKgtl
 ||.||||.|| | ||  .. ..| |        ..|.|||||||||   || ..||.||. |.||..|| |||||     | |||. ||. .| ..   
apvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyleckkrysea...

AWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLACDLVWSDPEKTSnVGWSLSARGISFSFDDITIEKFCQDNGLDLIVR
 .  .  ||| .||.|.. .|..||||||| .. .|...||..||. ||  |. .||.|.|||..  .|.  | ||   .| . ....|..   |||.||
lyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaev.egykesprgagkvfgakavkeflkkfkldlvvr

AHQIssemIRGGHKWHANGRMVTIFSAANYLS-MGNDSCVIRIDEQKTMQFCLLRP
|||.    .  |... |. ..||||||  |   . | ..|...||.    | .|.|
ahqv....vmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_PPP3C_pd Subfamily PPP3C 48-316 7.7e-67 219.0 In-house 41-312 (452) alignment 
Range on Protein: 48-316
Range on HMM: 41-312/452.0
VSKEEIRIISNYAAASFGSFSTLMRVDEdclPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHE
...|..  | . ||. . . .||..|.    |. ..||.|| | || ..| . | |  ..|.|||||||||   ||.|. |.|  . ||..||| |||||
leeeaalkiieeaakllkkektllevea...PitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhe

DYNTTMTYGFFDECRMKYGKKgtlAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLACDLVWSDPEKT------SNVGW
    |  . | .||..||...    . .....|. ||||||. .. ||.|||.||.|..|.||.|..|   .|..|. |||.|||| .       ..   
crhlteyftfkeeckikysee...vydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfv

SLSARGISFSFDDITIEKFCQDNGLDLIVRAHQISSEMIRGGHKWHANG--RMVTIFSAANYLSMG-NDSCVIRIDEQ
  |.|| |. .   .. .| |.| |  |.|||.   .  |  .| .| |   ..|.|||.||| .  | . |......
pnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 51-328 4.8e-66 215.6 In-house 13-283 (287) alignment 
Range on Protein: 51-328
Range on HMM: 13-283/287.0
EEIRIISNYAAASFGSFSTLMRVDEdclPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYN
..|  . . .   .  ...|..|..   |. ||||.|| ..|| |||   ||.   .|.||||||||| . .| ..||...  .|| .. | |||||  .
kdilevlekieeileplpallevea...pitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

TTMTYGFFDECRMKYGkkgTLAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSY--GLACDLVWSDPEKTSNVGWSLSARGI
   .||| .| . |..      . .  . |..||| | .  ..|||||||||... |...  ...||   .   ||  ||.|.|||| ..       |.|
inklyGfkeelkrkrq...erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkirai

SFSFDDITIEKFCQDNGLDLIVRAHQISSEmirgGHKWHANGRMVTIFSAANYLS-MGNDSCVIRIDEQKTMQFCLLRPVK
|  | . .......  ..|||||||..| |    |... .. |.||.|||. |     | ..|. ...   ..|  |.| .
svvfGkkevddllkkldidlivrahevsee....Gyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkped
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 105-327 1.1e-64 211.6 In-house 100-315 (317) alignment 
Range on Protein: 105-327
Range on HMM: 100-315/317.0
ISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRMKYGKKgtlAWLHIINAFNHLPLAALILDKVLCMHGGISPHI
 ..|.|||||||||   || |.||.|.. ||||..|| |||||  .  . |||. |.. .| ..    .    .||| |||.|.. .|.|||||||| ..
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaa...lyeafqlafnvlplcavvnkkilcmhGGiseel

QKLEDIDKIQRPTFIPSYGLACDLVWSDPEKTSnVGWSLSARGISFSFDDITIEKFCQDNGLDLIVRAHQIssemIRGGHKWHANGRMVTIFSAANYLS-
 .|. .||..||. ||  |. .||.|.||...   |.  |||| ...| . ....|..   |||.|||||.    .. |... |. ..|||||| .|   
ldlkqldklkrpldipdvGvladltwadpdaev.kgykesarGagkvfGakavkeflkkldldlvvrahqv....vedGyeffadrklvtifsapsycGq

MGNDSCVIRIDEQKTMQFCLLRPV
. | ..|...|.. .. . .||| 
ldniaavlsvdkklkisinvlrpe
subfamily_PPP5C_pd Subfamily PPP5C 49-321 1.3e-64 211.2 In-house 36-303 (322) alignment 
Range on Protein: 49-321
Range on HMM: 36-303/322.0
SKEEIRIISNyAAASFGSFSTLMRVDED-CLPVHIVGDLHGHFGDLRRIFGIHGAPGISH-YVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNH
 |  ..|... | . . . ..|. .. .    . . ||.||.| ||  || ..| |. .. |.| ||.||||   .|....|.... |||.|.|| ||||
kkyalkille.akellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnh

EDYNTTMTYGFFDECRMKYGKKgtLAWLhIINAFNHLPLAALILDKVLCMHGGIS-PHIQKLEDIDKIQRPTFIPSYGLACDLVWSDPEKtsNVGWSLSA
|  |    ||| .|...|| .|  .| |   . || |||| .| .||| .|||.   .  .|.|. ||.| .  |. || ..|.||||..  . | | | 
esdnmnklyGfegevkakytek..vadl.ftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe..anGrspsk

RGISFSFDDITIEKFCQDNGLDLIVRAHQISSEmirgGHKWHANGRMVTIFSAANYL-SMGNDSCVIRI-DEQKTMQF
||... |     .||...|.|.||.|.|.. .|    |.. . .|...|.||| ||  .||| ...|.. .......|
rGvgvqfGpdvtkkflkennleliirshevkee....GyevehdGklitvfsapnycdqmgnkgafitlrgddlklkf
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 60-330 4.5e-64 209.6 In-house 15-277 (284) alignment 
Range on Protein: 60-330
Range on HMM: 15-277/284.0
AAASFGSFSTLMRVDedcLPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFD
| . |     |. |.    |. |.||.||.| || |.|   | |  . |.|||||||||.. .||..||.||. ..|.|.|. |||||       |||..
afsifnkqpmlievn...spinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfye

ECRMKYGKKGtlAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPS-YGLACDLVWSDPEKTsNVGWSLSARGISFSFDDITIE
||. .| |     .  .   |  .||.||. ...||||||.|  .|.. ..  |.||   |    || |..|||| .  . ||   .||.|. |   .. 
ecqrrynkps..vyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnf.qkgwnpnsrgvsyvfgsdalr

KFCQDNGLDLIVRAHQIssemIRGGHKWHANGRMVTIFSAANYLS-MGNDSCVIRIDEQKTMQFCLLRPVKKS
|. .   .||.|||||.    .. |... || |.||||||  |   . | ..|. ....    | .||| || 
klldrlqidlvvrahqv....vqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkki
PPP_2 80-275 4.5e-63 205.5 In-house 1-197 (198) alignment 
Range on Protein: 80-275
Range on HMM: 1-197/198.0
VHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRMKYGkkGTLAWLHIINA
|...||||| . || ..|   . .  ..|.|||||||||....|...||.|. . ||....| |||||. . . .||| .|.  |.|  |. .. .. . 
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkg..gkkvykklqev

FNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLACDLV----WSDPEKTSNvGWSLSARGISFSFDDITIEKFCQDNGLDLIVRAHQI
|. ||||||| .|||..|||.|..|..|..| |..|.. .|. |. .||     .|||..... ... ||||... |   ..|.....| |.||.|||..
felLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekee.llansarGagllfgpdvteelleknklkliiRaHev
PPP_4 80-275 1.4e-60 197.7 In-house 1-196 (197) alignment 
Range on Protein: 80-275
Range on HMM: 1-196/197.0
VHIVGDLHGHFGDL-RRIFGIHGAPG-ISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRMKygkKGTLAWLHII
| .|||.|| . ||  ... . | |   ..||||||||||| ...|...||.|. . ||....| |||||. ...  ||| .|.  |   .|  ..  . 
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek...hgkeilkklq

NAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIP-SYGLACDLV-WSDPEKTSNVgWSLSARGISFSFDDITIEKFCQDNGLDLIVRAHQI
. |. ||||||| .|||..|||.|.....|..|..|.|.. .| . ....||  ||||... .  .. |.||... | .  .|||...|.|.||.|.|..
dvfdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeg.lansvrGagllFgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 46-326 5e-60 196.2 In-house 18-291 (307) alignment 
Range on Protein: 46-326
Range on HMM: 18-291/307.0
VTVSKEEIRIISNYAAASFGSFSTLMRVDEDCLpvhIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGN
.  .|||.  .   | . | |  .|. .|  |.   .||||||.| ||  .| . | |  . ||| |||||||   .|...||..|.  ||... | |||
iqytkeefenviyeaqtifssekalvdidppcv...vvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgn

HEDYNTTMTYGFFDECRMKYGKKGTLAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLACDLVWSDPEkTSNVGWSLSA
||       |||..||     | |   |  .  .|| ||..|||  |.||||||.|| .  |... .  .|   |  |.  |..|.||.  | . |  |.
heiarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpd.psvfewkass

RGISFSFDDITIEKFCQDNGLDLIVRAHQISSEmirgGHkWHANGR-MVTIFSAANYLSM-GNDSCVIRIDEQKTMQFCLLRP
||  |.|    |.  |.  |..||.||||.  .    |. |   || ..|||||  |  .  |  ||...||   .|   . |
rgsgftfgtnviddvckrlgveliirahqmcfd....gy.wvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvp
PPP_5_Dcr2 80-275 1.1e-59 194.7 In-house 1-198 (199) alignment 
Range on Protein: 80-275
Range on HMM: 1-198/199.0
VHIVGDLHGHFGDL-RRIFgIHG-APG-ISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRMKYgkKGTLAWLHI
| ..||||| ..||  ..|  .|  |     |||||||||||....|...||.|. ..||....| |||||| ...  ||| .|.  ||  .|  ..  .
vtvcGDlHGqlddlllilf.keggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlsky..hgkkiykil

INAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIP-SYGLACDLV-WSDPEKTSNVGWSLSARGISFSFDDITIEKFCQDNGLDLIVRAHQ
 . |. ||||||| .|||..|||.||.|...|...||.|.. || . |  .||. ||||... .  .  | ||... |    .|||...|.|.||.|.|.
sdvfdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshe

I
.
l
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 64-327 1.9e-58 191.1 In-house 36-295 (297) alignment 
Range on Protein: 64-327
Range on HMM: 36-295/297.0
FGSFSTLMRVDEDCLPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRM
.. | .   . |   |....||.||.| || |.|   | |  . |.||||||||||  |||..||.||.  .|  ||| |||||      .|||..||. 
ldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkvygfyeecqk

KYGKKGTlaWLHIINAFNHLPLAALILDKVLCMHGGISPHIQK---LEDIDKIQRPTFiPSYGLACDLVWSDPEKtSNVGWSLSARGISFSFDDITIEKF
.|       .  . . || |||. || .|.||||||.|| . |   |. . ||.|.|     .| .||.|.||      |.    ||    |   .. | 
ryqsvrm..yaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierste.gkerlvadllwadpis.glsgfmenqrgagcgfgrdavlkl

CQDNGLDLIVRAHQIssemIRGGHKWHANGRMVTIFSAANYLSM-GNDSCVIRIDEQKTMQFCLLRPV
| .  |||..||||.    .. |... |  ..||||||  |     | ....  ||.    | .||| 
csefkldlvcrahqv....vqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 50-322 2.4e-58 190.8 In-house 9-270 (280) alignment 
Range on Protein: 50-322
Range on HMM: 9-270/280.0
KEEIRIIsNYAAASFGSFSTLMrvdEDCLPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDY
.| | ||     | |   | |    |   |....||.| .. |. |.| . |     . .||||||||| |||| ..||.. .  | |...| |||||  
heiiaii.rmveaifmeesnlc...eaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetp

NTTMTYGFFDECRMKYGKKgtlAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLACDLVWSDPEKTSNvGWSLSARGIS
.    |||. ||. |||      |  . ..||..|...||  .|||||||.|| . .|. | .| ||      ||  ||.|||| .  . ||  | ||||
svnkiygfyvecqykygvg...lwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkge.gwfhsirgis

FSFDDITIEKFCQDNGLDLIVRAHQIssemIRGGHKWHANGRMVTIFSAANYLS-MGNDSCVIRIDEQKTMQFC
. |    .|. |.   .|||.||||.    .. |..  |  |..|.||  || . . | ..|. .. .  . | 
ymfgkgvveqacksleidliirahqv....vqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfq
subfamily_PPG1_pd Subfamily PPG1 78-322 4.1e-58 190.0 In-house 41-291 (300) alignment 
Range on Protein: 78-322
Range on HMM: 41-291/300.0
LPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRMKYGKKGTlAWLHII
 || .|||.|| | |.  || | |    . |.|||||||||   .||..||.. .  ||  . | |||||  . | .|||. ||  ||| . .  | .. 
spvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyteclrkyggnsr.vwkylt

NAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFIPSYGLACDLVWSDPE--------KTSNVG--WSLSARGISFSFDDITIEKFCQDNGLD
. |..| |||.| ... |.|||.|| .. ...|  ..|   .|  |  .||.|||||        .  . |  .  | ||  .|.    .||| . | ..
eifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsqrgagysygkdvvekflrnndmn

LIVRAHQISSEmirgGHKWHANGRMVTIFSAANYLS-MGNDSCVIRIDEQKTMQFC
 |.||||.  |    |.. . .... |..|| ||    || . .. . |.. . | 
riirahqlcne....gyqilfdnklstvwsapnycyrcgnkasilelyekderyfn
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 61-327 1.6e-56 184.4 In-house 29-289 (290) alignment 
Range on Protein: 61-327
Range on HMM: 29-289/290.0
AASFGSFSTLMRVDEdclPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDE
   .  . .|..| .   |. ||||.|| ...| | |   | |   ...||||||||| . .|  .||. |. .|. .. | |||||  .    ||| .|
eeileplpallevea...pivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrlygfkee

CRMkygKKGTLAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTFI--PSYGLACDLVWSDPEKTSNVGWS-LSARGISFSFDDITI
      |.|.  |    . |. |.| | .  |.||||||||..|.  | .  ...|        ||  ||.|.||..  .   .    |.||  | . ..
lar...krgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvvfgkkgl

EKFCQDNGLDLIVRAHQISSEmirgGHKWHANGRMVTIFSAANYLSM-GNDSCVIRIDEQKTMQFCLLRPV
.....  .|.||||||... |    |...  . ..||.|||  |     |  ..... |   ...  |.| 
ddllkklalslivrahevkee....gfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 49-328 2.2e-56 184.3 In-house 7-301 (302) alignment 
Range on Protein: 49-328
Range on HMM: 7-301/302.0
SKEEIRIISNYAAASFGSFSTLMRVDEdclPVHIVGDLHGHFGDLRRIFGIHGAP-----------GISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPD
||.|.  . .   . .   .||...     || ||||.||.| || ||.  .                ...||||||||||.. || . |..|.  ||| 
sksellllieaviellkkektlaeisp...PvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlypt

HLFLCRGNHEDYNTTMTYGFFDECRMKYGKKG-TLAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTF-IPSYGLACDLVWSDPEK
.  | |||||     ..||| .|   ..|||     | .  ..| ..|||||. .|.||.||||||... ||||.||.|| . .    || ||...||  
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

TSNVGWS--------LSARGISFSFDDITIEKFCQDNGLDLIVRAHQisseMIRGGHKWHANGRMVTIFSAANYLSMG-NDSCVIRIDEQKTMQFCLLRP
.  .              ||.|..|.. .....|.  .|.|||||||    ||  |.|..|. ...|||||..|.    |   |...| .  ..   ||.
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahq....miPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn

VK
 |
kk
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 48-326 5e-56 183.1 In-house 7-300 (302) alignment 
Range on Protein: 48-326
Range on HMM: 7-300/302.0
VSKEEIRIISNYAAASFGSFSTLMRVDEdclPVHIVGDLHGHFGDLRRIFGIHGAP-----------GISHYVFLGDYVDRGRQGIETVMLLMAYHCLYP
 ||.|.  . .   . .   .||...     || ||||.||.| || ||.  .                ...||||||||||.. || . |..|.  |||
ysksellllieaviellkkektlaeisp...PvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyp

DHLFLCRGNHEDYNTTMTYGFFDECRMKYGKKG-TLAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTF-IPSYGLACDLVWSDPE
 .  | |||||     ..||| .|   ..|||     | .  ..| ..|||||. .|.||.||||||... ||||.||.|| . . .  || ||...|| 
tnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpl

KTSNVGWS--------LSARGISFSFDDITIEKFCQDNGLDLIVRAHQisseMIRGGHKWHANGRMVTIFSAANYLSMG-NDSCVIRIDEQKTMQFCLLR
 .  .              ||.|..|.. .....|.  .|.|||||||    ||  |.|..|. ...|||||..|.    |   |...| .  ..   ||
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahq....miPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr

P
.
n
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 78-326 1.4e-53 175.3 In-house 7-255 (263) alignment 
Range on Protein: 78-326
Range on HMM: 7-255/263.0
LPVHIVGDLHGHFGDLRRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRMKYGKKGTL--AWLH
 |. |.|| ||.. || |||   ||   ..|.||||||||| . .| .|||.. .   | ...| |||||       |||. | . .. ..      . |
apinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvynh

IINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQRPTF-IPSYGLACDLVWSDPEKTSNVGWSLSARGISFSFDDITIEKFCQDNGLDLIVRAHQ
. . |...||.|..  ..||||||||||.. |.||  |  |     .. |||||.|.|||| ..       | ||  |    .. .|.   .||||||||
fnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivrahq

IssemIRGGHKWHANGRMVTIFSAANY-LSMGNDSCVIRIDEQKTMQFCLLRP
.    .  |. . |. |..|.|||. | . . | ..|. ...   . |  |.|
v....veygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 104-329 1.9e-48 158.3 In-house 118-336 (339) alignment 
Range on Protein: 104-329
Range on HMM: 118-336/339.0
GISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRMKYGKKgtlAWLHIINAFNHLPLAALILDKVLCMHGGISPH
|  .|.|||||||||   .| |.|| | .  |||...| |||||      .|||. |   .|  .    .  . | || .|..|.| . ..||||||| |
gykrylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaq...lyecfqnmfnvfpfcavinntimcmhggiseh

IQKLEDIDKIQRPTFIPSYGLACDLVWSDPEKTsNVGWSLSARGISFSFDDITIEKFCQDNGLDLIVRAHQIssemIRGGHKWHANGRMVTIFSAANYLS
.  ....  ..||  ||  |.  || |.||. | . |.  |||| || |   ..  | .   |....| ||.    .  |...    |.|||||| ||  
ltsfnqfsvfkrpleipdvgvltdltwadpdpt.ekgykpsargasfvfgppalraflkkldlqmvirghqv....vedgyeffdgrrlvtifsapnycg

MG-NDSCVIRIDEQKTMQFCLLRPVKK
   | ..|. ||..  .   ..||  .
qndntaavfsidkklkisinvfrpesr
subfamily_PPPLV_pd Subfamily PPPLV 79-317 3.3e-44 144.3 In-house 25-279 (290) alignment 
Range on Protein: 79-317
Range on HMM: 25-279/290.0
PVHIVGDLHGHFGDLRRIFGIHGA----PGISHYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRMKYGKKGTLAWL
|....||||| . ||  .             . ..|||||||||  ..| .  |.| . ||| ...| |||||    . .. .  |. .|.|..   .| 
ptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkfgdsleevwe

HIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIDKIQR-----PTFIPSYGLACDLVWSDPEK----------TSNVGWSL-SARGISFSFDDITIE
 . |.|. ||||| | .||.|.|.||   |.    |  ||      .  |    || |..||||..          . | |.   . || .  |   ..|
afnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGfvdndrrGtghvfsedale

KFCQDNGLDLIVRAHQISSEmirgGHKWHANGRMVTIFSAANYLSMGNDSCVIRIDEQK
.| . |.|. ..|||..  .    | .   .||..|.||...|    |.. .| .|..|
aflkrnnlsfvlrahevkek....GirlqqkgrlltvfsssrycGssneaalilvdkkk
Metallophos Calcineurin-like phosphoesterase 78-274 1.3e-39 129.6 Pfam-A 1-197 (200) alignment 
Range on Protein: 78-274
Range on HMM: 1-197/200.0
LPVHIVGDLHGHFGDL----RRIFGIHGAPGISHYVFLGDYVDRGRQGIETVMLL--MAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRM--------
|.. ..|||||.. ||    .... | . ...  ..||||.||||. ..|| .||   ..  |.|...||.|||||... .  |||..|.          
lrilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglang

-----------------------KYGKKGTLAWLHIINAFNHLPLAALILDKVLCMHGGISPHIQKLEDIdkiqrptfipsyglacdlvwsdpektsnvg
                       .|...|. |. .. . |. |||.||.  |.|..||..|.. .  .||                              
eeeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi..............................

wslsargISFSFDDITIEKFCQDNGLDLIVRAHQ
        |. |     ||.....|.||..|.|.
.......gselfgpdalekllekygvdlvlrGHt
subfamily_PPP7C_pd Subfamily PPP7C 80-218 1.6e-37 122.2 In-house 66-204 (383) alignment 
Range on Protein: 80-218
Range on HMM: 66-204/383.0
VHIVGDLHGHFGDLRRIFGIHGAPGIS-HYVFLGDYVDRGRQGIETVMLLMAYHCLYPDHLFLCRGNHEDYNTTMTYGFFDECRMKYGKKGTLAWLHIIN
| . |||||.. ||  |.   | |  .  ||| ||.||||....| ...|.|.  .|| ...| ||||||.   . |||  |   || ..|.     . .
vtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlled

AFNHLPLAALILDKVLCMHGGISpHIQKLEDIDKIQRPTF
 |  ||||.|| .|.| .||||| .. .|| .|||.|  .
vfawlplatlidekilivhGGis.dktdlelldkierskl
subfamily_PPP7C_pd Subfamily PPP7C 226-321 1.2e-11 36.9 In-house 238-329 (383) alignment 
Range on Protein: 226-321
Range on HMM: 238-329/383.0
CDLVWSDPEKTSNVgWSLSARGISFSFDDITIEKFCQDNGLDLIVRAHQISSEmirgGHKWHANGRMVTIFSAANYLSMG-NDSCVIRIDEQKTMQF
 |..||||....   .. . ||    |     .|. |  .|.|..|.|.   |    |...  . ...|||||.||  .| |    ... ...| ..
ldilwsdpkakeGc.kpntlrGgGsyfGpdvtkkllqkynlkllirsheckpe....GyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpri
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 81-198 9.8e-07 20.9 Pfam-A 4-89 (156) alignment 
Range on Protein: 81-198
Range on HMM: 4-89/156.0
HIVGDLHGHFGDLRRIFGIHgaPGISHYVFLGDYVDRgrqgIETVMLLMAYhclyPdhLFLCRGNHEDYNTTMTYGFFDecrmkygkkgtlawlhiinaF
 |..||||.. .|...   .   .. .....||.|..     |.| ||...    |  .  .||||.. .. ... .                      .
aiiSDlHgnldaleavledi..kevdlilhaGDlvep....eevvelledi....p..vlavrGnhDeaelpkelavel....................l

----------NhlplaalildKVLCMHG
          .          .|| .||
laaaaleiegd..........rvllvhg