Gene ZC477.2 in Caenorhabditis elegans

Synonym: CELE_ZC477.2, ZC477.2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf5
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP233_AA protein Get Run
CeleP233_AA_45-348 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 48-348 3.5e-153 502.1 In-house 2-301 (302) alignment
Range on Protein: 48-348
Range on HMM: 2-301/302.0
SKNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALLARTEQDiTDEQKSNFStrqFVRDKYVFLGNYIDKGPRSIECICLLFAF
.|...|..|......|||...|||..|.|.|.|||..||.||.|.||.|.|.||.... ....||..|   |..||.||||.|.|.|..|||||||.||.
rkkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvske.eakkksays...fssdkfvflGdyvdrGsksieciclvfal

KICFPQKYILLRGPHECPSVN-SSEFLGVMET-FSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEDPLATDLL
|...|..||||||.||....| ...| ...|. ......|.|..||||.||.|||||.||.|||||||||||.|.|.|||.|||||||..|||.||.|||
kvlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdll

FADTLDFDLIHIPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNES-NYGAVLKIDGNAKITIISL
|||.||..|......||||..|..|..||..|||||...|...|||||.|.|...|.|..||..|.|.|||......||| |.|||||.|.|.|..|..|
fadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvl

LPQQ
 ...
rnkk

subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 46-347 1.7e-152 499.9 In-house 1-301 (302) alignment
Range on Protein: 46-347
Range on HMM: 1-301/302.0
KRSKNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALLARTEQDiTDEQKSNFStrqFVRDKYVFLGNYIDKGPRSIECICLLF
|..|...|..|......|||...|||..|.|.|.|||..||.||.|.||.|.|.||.... ....||..|   |..||.||||.|.|.|..|||||||.|
kyrkkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvske.eakkksays...fssdkfvflGdyvdrGsksieciclvf

AFKICFPQKYILLRGPHECPSVN-SSEFLGVMET-FSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEDPLATD
|.|...|..||||||.||....| ...| ...|. ......|.|..||||.||.|||||.||.|||||||||||.|.|.|||.|||||||..|||.||.|
alkvlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqd

LLFADTLDFDLIHIPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNES-NYGAVLKIDGNAKITII
|||||.||..|......||||..|..|..||..|||||...|...|||||.|.|...|.|..||..|.|.|||......||| |.|||||.|.|.|..|.
llfadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsis

SLLPQ
.| ..
vlrnk

PP2Ac_SM00156 53-347 6e-101 330.0 In-house 2-270 (271) alignment
Range on Protein: 53-347
Range on HMM: 2-270/271.0
SSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlarteqditdeqksnFSTRQFVRDKYVFLGNYIDKGPRSIECICLLFAFKICFP
|..||......|.. .|.|.||.||||||||.||.||...||.| |                ..... ..||||||.|.|.||.|||.|.||||.||..|
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrll...............elageppeekyvFlGdYVDRGpqsiEvillLfalkilyp

QKYILLRGPHECPSVNssEFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRpLKDATEDPLATDLLFADTldf
.|..|||| ||..|||  .. |..|... .. |.|..||.||||..||||.|..||||.|||.||.|.|..||||.||  |. .|..|..|||..|.   
ekvvLLRGnHEsssvn..kiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkr.vkekpeegllidllwsdp...

dlihiPTRKPKYEFNViRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE-SNYGAVLKIDGNAKITIISLLPQ
      .........  |..||...|.||..|..|.|||||||.|. |. ||.||..|.|.|||... ...| ||..||||.. |.|..|..| .|
.....eqkekgfqpsk.rglsvvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq

0045823 Metallo-dependent phosphatases 48-348 5.9e-76 249.0 In-house 39-325 (473) alignment
Range on Protein: 48-348
Range on HMM: 39-325/473.0
SKNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRaLLARTEqdiT---DeqksnfstrqfvrdKYVFLGNYIDKGPRSIECICLL
  . |. ........ ... .||| || |.|....||||.||...|| | ||.. .       |              ..||||...|.|| |.|...||
kegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlr.llekig...fpped..............rlvflGDlvDrGpdslevlell

FAFKICFPQKYILLRGPHECPSVNSSefLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLkDATEDPLATDL
.|.||..|.. .|||| ||.  .|    .| ....      .. . |.| ....|||||.|.|||.||||.|| |.....||.|.||| .  .|.|..||
lalkikypgnvfllrGNHElrllngl..ygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpl.eipddgllldl

LFADTlDFDLIHIPTRKpKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKR------LITIFNSTGFQN-ESNYGAVLKIDGNA
|..|. . |  .  .|   .  |  |........ || .|..|..|.||.|.|  || ||...  ..      .||.| .. . .   | .|||.||.. 
lwsdP.weddgdgllrl.rffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl

kITIISLLPQQ
 |..| . | .
.isfiqfdpsp

subfamily_PPP1C_pd Subfamily PPP1C 47-347 7e-71 231.7 In-house 5-279 (282) alignment
Range on Protein: 47-347
Range on HMM: 5-279/282.0
RSKNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALLARTEQDITdeqksnfstrqfvrdKYVFLGNYIDKGPRSIECICLLFA
... .|...|. .....  . ....  |.|..|||...||.||...|| | . .    . .               .|.|||.|.|.| .|.| |.||.|
gkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpes...............nylflGdyvdrGkqsletivllla

FKICFPQKYILLRGPHECPSVNSseFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLkDATEDPLATDLLF
.|| .|..  |||| ||. |.|   . | ..     . .|. |.|...|...||||.| .||||||||.||.|.| |.||||.||| .  |. |..|||.
ykikypenlfllrGnhesasinr..iyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPl.evpekgllcdllW

ADTlDFDLIhiptrkpKYEFNViRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQN-ESNYGAVLKIDGNAKITIISLL
.|  | .         ... |  | .|. ... .|..|..|..|.||.|.|. |  ||.||....|.|.| .. . .   | ||||..| . ...   | 
sdp.dkevl.......gwsend.rGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilk

PQ
|.
pa

0049330 Metallo-dependent phosphatases 46-348 1.7e-68 224.1 In-house 24-300 (309) alignment
Range on Protein: 46-348
Range on HMM: 24-300/309.0
KRSKNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRaLLARTEQDitdeqksnfstrqFVrDKYVFLGNYIDKGPRSIECICLLF
 .    || .|.. ..  ... .|.| ||.|.|....||||.||...|| | ||.. . .              . |..||||...|.|| |.|...||.
llklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlr.llekigfp.............pe.drlvflGDlvdrGpdslevlllll

AFKICFPQKYILLRGPHECPSVNSSefLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEdPLATDLL
|.|...|.. .|||| ||.  .|    .| ....      .. ..|.. ....|||||.|.||||||||.|| |.....||...|||    . .| .|||
alkllypdnvfllrGNHElrllngl..ygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipld.gllcdll

FADTLDFDLIhiptrkpkYEFNViRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQN-ESNYGAVLKIDGNAKITIISL
..| |..           .  |. |...| ... || .|..|..|.||||.|  |. ||..| ...|||.|... . .  .|.||||.||.. .|... .
wsdplpireg........fapnp.rglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllf

LPQQ
 | .
epvp

subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 35-349 1.6e-67 220.6 In-house 7-296 (298) alignment
Range on Protein: 35-349
Range on HMM: 7-296/298.0
LKKMIQPGRVMKRSKNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlARteqditdeqkSNFSTRQfvrdKYVFLGNYIDKG
| .... .   |.  . .....| .... . . ||| . |.|| ||..| ||.||.. || | . ..          ..|  ..     |.|||.|.|.|
lievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlf.dk..........agfppda....nylflGdyvdrG

PRSIECICLLFAFKICFPQKYILLRGPHECPSVNSSefLGVMET-FSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLk
  ..| |.||.|.|. .|....|||| |||...|     |  |      .  .....|...|...||.|..|..|||.|||.|..|.|....|..|||  
rqnlevivlllaykvkypnnffllrGnheceainrv..yGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpf.

DATEDPLATDLLFADtldfdlihiPTRK-PKYEFNvIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE-SNYGAVL
|. |. ||.|||.||         |...   .. |  | .||.. | .| ...||... |..|.|  |  || ||.||.|.||| .  . ..  |  ||.
dskeeslaidllwad.........penavkgwaen.srGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavm

KIDGNAKITIISLLPQQS
|.| . ...   | |.. 
kvdeklvvsfevlkpekk

PPP_3 52-339 3.2e-67 219.4 In-house 2-264 (271) alignment
Range on Protein: 52-339
Range on HMM: 2-264/271.0
LSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLyrALLARTEQDITDeqksnfstrqfvrDKYVFLGNYIDKGPRSIECICLLFAFKICF
||.||. .... . . ..||.||.|.||||||.||.|| ..||    | .. ... .              ||.|||.|.|.|  |.|...||.|.|| .
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDL..lelfknggpspe.............tkYlFlGdyVDrGkkslEvlllLlalkiky

PQKYILLRGPHECPSVNSSeFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEDPLATDLlfadtld
|.. .|||| ||. ..|.  .    | ..  . ||..||..| |...||||.. .|.|.||||.||...|...|.|..|. .  .| .| ..|       
pkevhLlRGnhEsrqinkv.YgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldll.......

fdlIHIPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGF-QNESNYGAVLKIDGNAKI
   .  ...| .   |  | ..... . ....|.|| .||||||.|  .. ||... .....|.|  . . .. || ||.||.. ... 
...lssdpekeeglenskrGagllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealts

0053225 Metallo-dependent phosphatases 50-345 2.7e-65 213.7 In-house 20-289 (293) alignment
Range on Protein: 50-345
Range on HMM: 20-289/293.0
NNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlARTEQDitdeqksnfstrqFVrDKYVFLGNYIDKGPRSIECICLLFAFKI
  || .|.. ..  ... .|||.||.|.|....||||.|||..|| . | .. . .              . |..||||...|.|| |.|...||.|.|.
kllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlall.ekigfp.............pe.drlvflGDlvdrGpdslevlelllalkl

CFPQKYILLRGPHECPSVNSSEFlGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEdPLATDLLFADT
..|.. .|||| ||.  .|     .  ||.   . ... . ... ....||||..|.|||.||||.|| |.....||.|.|||   .| .| .|||. | 
lypdnvvllrGNHElmllnglyg.fgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriple.gllldllwsdp

LDFDLIHIPTrkpkyefnviRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQN-ESNYGAVLKIDGNAKITIISLL
 ... ...            |...| ... || .|..|..|.||||.|  || ||... ...|.|.|... . .  .|.||||..|.. ..... . 
dlwsgwlpsy..........rglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfa

subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 51-349 7.2e-65 211.7 In-house 9-284 (287) alignment
Range on Protein: 51-349
Range on HMM: 9-284/287.0
NLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlarteQDITDEQKSnfstrqfvrdKYVFLGNYIDKGPRSIECICLLFAFKIC
..| .....| . . . ..  . |.|| ||.|..||.||...|| | .     ...    |           .|.|||.|.|.|..|.| . |||..|| 
afsdkdilevlekieeileplpalleveapitivGdihGqlddllrif.....navGaapkv..........qylflGdyvdrGakslevslllfslkia

FPQKYILLRGPHECPSVNSseFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDAT-EDPLATDLLFADt
.|.|  |||| ||.  .|     |  | .  .. ....|.||. || .|| | |...|||.||||||.| |..... .|.| .. . .. |  |||.|| 
ypkkvhllrGnhevkkink..lyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwad.

ldfdlihiPTRK-PKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQ-NESNYGAVLKIDGNAKITIISLLPQ
        |...   .|.| || .||.. .  | ....|....||.|.|  .  || |. .|||.|.| .. .. ...|.|||....   ..... | |.
........pekdaktfelnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpe

QS
. 
df

PPP_1 53-332 1.6e-61 200.9 In-house 2-263 (264) alignment
Range on Protein: 53-332
Range on HMM: 2-263/264.0
SSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLyRALLarteqditdeQKSNFSTrqfvRDKYVFLGNYIDKGPRSIECICLLFAFKICFP
...|. .... . . ..||.||.|||...||.||.||.|.||   |           ... .|     . .|.||| |.|.|  |.|...||.|.|. .|
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDL.lklf..........kvggpsp....etnYlFlGDyVDRGkdSvEilllLlalklkyp

QKYILLRGPHECPSVNSSeFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKdATEDPLATDLLFADTLdf
..  |||| ||. .|..  .    |    .. |.|.| . ..| ..||||.. .|||.||||.|| |.. ..|||..|  .  .|.  ..||| .|.   
kelfllRGNHEsrqvtkv.ygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrkte.vpeegklcdllekdvd..

DLIHIPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNS-TGFQNESNYGAVLK
.|.. .... .   | || .. .... ....|..|.|||||||.|. .. ||.|.......||| . . ... || ||..|
illsddkeqeeavansiRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 46-347 9.2e-61 198.7 In-house 3-315 (317) alignment
Range on Protein: 46-347
Range on HMM: 3-315/317.0
KRSKNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALLAR----TEQDIT-----------DEQKSNF-------STRQFVRDK
|.... ....|.  .|    . | ||.  .|. ||||..||.||.|.||   |       ..|.             .. |...         ..  ..|
kkcqdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwplssqeeksepkslllesskdvkqtvaavksvnkevtkgykk

YVFLGNYIDKGPRSIECICLLFAFKICFPQKYILLRGPHECPSVNSSefLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWE
|.|||.|.|.|| ||| . ||||.|. .|.| .|||| ||  .|| .   |  .     . ..... |. ||  .||.|||..||||.|||||  |.. .
ylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntq..yGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

DIRKIKRPLkDATEDPLATDLLFADtldfdlihiPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQ-
 . |.|||| | ..  . .|| .||         |  . |.  .  |  . .. ..|| .|..|..|.|..|.|  |  || ||....|.||| .  .  
qldklkrpl.dipdvGvladltwad.........pdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycG

NESNYGAVLKIDGNAKITIISLLPQ
.  | .|||..| . ||.|  | |.
qldniaavlsvdkklkisinvlrpe

subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 49-343 5e-60 196.3 In-house 5-279 (284) alignment
Range on Protein: 49-343
Range on HMM: 5-279/284.0
KNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALLARTEQDITDEQKSnfstrqfvrDKYVFLGNYIDKGPRSIECICLLFAFK
.. |. .|.  .|    . | ||.  .|. |||...||.||.| ||   |       ..||.|.         .||.|||.|.|.|| ||| | ||||.|
qkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeake.........kkylflgdyvdrgpfsievitllfayk

ICFPQKYILLRGPHECPSVNSSefLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLkDATEDPLATDLLFAD
. .|.| .|||| ||   ||     | ..     . ..... |. ||  |||.|||..||.|.|||||  | . ... |..||. | ..  . .|| .||
lllpdkvfllrgnhesrpvnmq..ygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpi.dipdigviadltwad

tldfdlihiPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQN-ESNYGAVLKIDGNAKITIIS
         |  . ..  .  |    .. ..|| .|..||.|.|..|.|  |  || ||....|.||| .  .     | .|||..| .  ...  
.........peaevegykesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftv

subfamily_PPP3C_pd Subfamily PPP3C 50-337 4.4e-57 186.8 In-house 39-313 (452) alignment
Range on Protein: 50-337
Range on HMM: 39-313/452.0
NNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALLarteqdiT-DeqksnfstrQFVRDKYVFLGNYIDKGPRSIECICLLFAFK
 .|.....  . . . . .|||..|.||.||.|||||.|| |.|| . .                    .    ||.|||.|.|.|  ||||.  |.| |
grleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfe.......vgG.........dPastkylflGdyvdrGyfsiecvlylyalk

ICFPQKYILLRGPHECPSVnsSEFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRpLKDATEDPLATDLLFAD
|..|... |||| |||  .  .|..   |     . ....... |.|  .||||.. |. ||||||.|| ..| .||.|..| .|.  .  .  |||..|
iaypstlfllrGnhecrhl..teyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldr.fkeppasGplcdllWsd

TLD-FDLIHiptRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSE------KRLITIFNSTGFQN-ESNYGAVLKIDGNA
 |. ..  .    . |.  | .|  |..|. .||..| .| .|  |||.|     ||| . .        |||.| .. . .  .| .||||.. | 
Pledygeek...teekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennv

subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 57-346 1.7e-56 184.4 In-house 11-274 (280) alignment
Range on Protein: 57-346
Range on HMM: 11-274/280.0
VWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRaLLARTeqditdeqksNFSTRQfvrdKYVFLGNYIDKGPRSIECICLLFAFKICFPQKYI
. .| . . . .. .. ..|| |||.| ||.||.. || | |.||.          .|   |    .|.|||.|.|.|   .| |.||.|.|. .|....
idrviekckkiltaqatmvevdapvavcgdlhgqytdllr.lfarv..........sfppdq....nylflgdyvdrgrqqlevillllaykvrypnnfl

LLRGPHECPSVNSSefLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLkDATEDPLATDLLFADtldfdlih
.||| ||. |.|     |  .     . ......|.| .  .||.|.|. .|||.|||.|..| |..|.....||. |. .. ||.|||.||        
ilrgnhevisinrk..ygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpf.dsedeclamdllwad........

iPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE-SNYGAVLKIDGNAKITIISLLP
 |  |     .  | .||.. .  | ...||... ||.| |  |  || ||..|.|.|.| .  . .| .|  |||..| . ....  | |
.penkvtgwaensrgvsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkp

subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 34-349 2.5e-56 184.1 In-house 6-296 (299) alignment
Range on Protein: 34-349
Range on HMM: 6-296/299.0
FLKKMIQPGRVMKRSKNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlarteqditdeQKSNFSTRQfvrdKYVFLGNYIDK
.| |... |   ||  ...  .|. ..|.   . | ..  |.|| ||. | ||.||.. || | .           .|..|        ...|||.|.|.
llskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrif...........dkagfppdv....nflflgdyvdr

GPRSIECICLLFAFKICFPQKYILLRGPHECPSVNSseFLGVMETFS-PNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPl
| . .| |.||..||| .|... .||| ||||..|     |  |      .  ..   |..||..|||. ..| .|||.|||.||.|.. . .|.. || 
grqnlelitlllcfkikyperffmlrgnhecpainr..vygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrp.

KDATEDPLATDLLFADTLDFdLIhiptrkpKYEFNvIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE-SNYGAVL
.|  .  |  |||.||  .. ..       ..  | .| .| .. .  |.. ...... |. |.|  |  || ||..|.|.||| .  .  .  |  |..
qdppnpslgidllwadpdqs.vk.......dwlan.vrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaim

KIDGNAKITIISLLPQQS
|.| |   |.  | | . 
kvdenlvctfvvlkptpk

subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 52-348 8.1e-56 182.3 In-house 8-278 (281) alignment
Range on Protein: 52-348
Range on HMM: 8-278/281.0
LSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlarteqDITDeqksnfstRqFVRDKYVFLGNYIDKGPRSIECICLLFAFKICF
.. .|. .| | |   | .|..|.|. .|..|.||.|..|.|| |..      .. .        |   ....||||.|.|.||.|.|.. |||..||..
ytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlf......ellg........r.vpeevlvflgdyvdrgpqslevlillftlkiry

PQKYILLRGPHECPSVNSSefLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATeDPLATDLLFADtld
... .|||| || .|||     |  .       ...  .|.. |  .|..| . ...||.|||.|| ||. ...|.. .|...     |  |||.||   
rdrivllrgnheiasvnki..ygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnld.rGlviDllwad...

fdlihiPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE-SNYGAVLKIDGNAKITIISLLPQQ
      |. | .  .. .| .| .. .. | . | .... ||||.|  |  ||. .| ..|||.|    . .   | .||||.| . .|....|.|. 
......pdnkveewkassrGssftfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpas

subfamily_PPZ_pd Subfamily PPZ 33-337 1.1e-55 182.2 In-house 5-284 (300) alignment
Range on Protein: 33-337
Range on HMM: 5-284/300.0
EFLKKMIQPGRVMKRSKNN-LSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlarteqdiTdeqKSNFSTRqfvrDKYVFLGNYI
| ..|... |   ||.||  |  .|.  .|    . |  . .|.|.| .| ..|||||.. || | .        |   |  |        .|.|||.|.
eiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlf........t...kcgfpps....anylflgdyv

DKGPRSIECICLLFAFKICFPQKYILLRGPHECPSVnsSEFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRP
|.| .|.| | ||...|| .|....|||| |||  |  .   |. .        || | | ..|  .||||.|  ||.|||||.|| | | ..||.. ||
drgkqsletillllcykikypenffllrgnhecanv..trvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrp

lKDATEDPLATDLLFADTLDfdlihiptRKPKYEFNvIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE-SNYGAV
  |  .  |  |||..|  |           ..| |  | .|  ||. |. .| .|| . |. |.|| |  || || .. |.|.|..  .  |  |.|||
.tdvpdfglindllwsdptd........ssnewedn.ergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgav

LKIDGNA
. .    
msvsegl

subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 74-348 8.7e-55 179.2 In-house 2-257 (263) alignment
Range on Protein: 74-348
Range on HMM: 2-257/263.0
LMEVSAPVTVIGDVHGNFHDLYRALLARTEqditdeqksnfSTrqfvRDKYVFLGNYIDKGPRSIECICLLFAFKICFPQKYILLRGPHECPSVNSSE-F
|.|. ||. . || ||.. || | . |              .|    . .|.|||.|.|.| .|.| | |||..|...|.|  |||| ||  ..|    |
llelqapinicgdthgqyndllrifnacga...........at....ktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygf

L-GVMETFSP-NHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEDPLATDLLFADTLDfDlihiptrKPKYEFNVIR
   . . |   . .. ....||. ||.|||.|.| ..|||.||||||.| | .||| |  ||. |   ||| |||.||    |          .| | ||
haelkkrfqreevyesvynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.d.......akgfepnkir

NMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE-SNYGAVLKIDGNAKITIISLLPQQ
 .| .. .  | ..|..... ||.|.|  | .|| ||...||||.|... .| |  || ||. ..   ..... | |..
aisnvfgkkevddlckrldidlivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkped

subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 50-347 5e-54 176.3 In-house 14-289 (290) alignment
Range on Protein: 50-347
Range on HMM: 14-289/290.0
NNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlarteQDITDEQKsnFstrqfvrdKYVFLGNYIDKGPRSIECICLLFAFKI
. .| ...... . . . ..    |.|| ||....||.||.. .| | .     ...    |  .        |..|||.|.|.|..|.|   ||| .||
dafsdkdileilekieeileplpalleveapivivgdihgqldallryf.....davgyppk..v........kflflgdyvdrgakslevslllfcyki

CFPQKYILLRGPHECPSVNSseFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDA-TEDPLATDLLFAD
 ...|  |||| ||.  ||   . |  | .      .. |.... |. ..| | ||.||||.|||||... ||| .. .|.|  .   .. |  |||.||
ryskkvhllrgnhevrkvnr..lygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwad

tldfdlihiPT--RKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGF-QNESNYGAVLKIDGNAKITIISLL
         ||  .   ...|  | .||.. . .. ....|. |.||.|.|     |. |  .|.|.|.| .  .  |..| ||....    ...|. | 
.........ptrdkddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlk

PQ
|.
pr

PPP_2 81-298 2e-50 164.3 In-house 1-196 (198) alignment
Range on Protein: 81-298
Range on HMM: 1-196/198.0
VTVIGDVHGNFHDLyrALLARTEQDITDeqksnfstrqfvrDKYVFLGNYIDKGPRSIECICLLFAFKICFPQKYILLRGPHECPSVNSSeFLGVMETFS
|||.||.||...||    | .. .....              ||.|||.|.|.| .|.|...||.|.|. .|.. .|||| ||. .||.  .    | ..
vtvcGDlHGqldDL..lilfknglpspe.............rkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkv.ygFkkevlk

PNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEDPLATDLlFADTldfdlIHIPTRKPKYEFNVIRNMSVMYNEAA
  . ||..||..| |...||||.. .|.|.||||.|........|.|..|. .  .| .| ..|   .      .  |..| .   |  | ....... .
kkggkkvykklqevfelLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldll.eeek.....lsdpkekeellansarGagllfgpdv

VTQFCEKFNLKLIIRSHM
.....||..||||||.| 
teelleknklkliiRaHe

subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 57-349 5.6e-50 163.3 In-house 8-276 (284) alignment
Range on Protein: 57-349
Range on HMM: 8-276/284.0
VWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlarteqditdeQKSNFSTrqfvRDKYVFLGNYIDKGPRSIECICLLFAFKICFPQKYI
| ..   ... |.|.  |.|| .|. . ||.||.| || | .           .|  |      | .|.|||.|.|.| . .| | ||||.|. ||....
vetllfhafsifnkqpmlievnspinicgdihgqfsdllrlf...........dkngfph....ranylflgdyvdrgkhcletilllfaykvifpnhff

LLRGPHECPSVNSSefLGVMETFSPNHFK-KIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEDPLATDLLFADTLDFDLI
.||| |||  .|     |. |     . |  ... |.  || |||.|.|||.|||.|||.|  |    ..| ||||. .   . || |.|..|  .|.  
mlrgnhecslinki..ygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkg

HIPtrkpkyefNvIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE-SNYGAVLKIDGNAKITIISLLPQQS
  |        |  | .| ..   |. .. ..... |..|.|  |  || ||...||.||| .  .  .  |  ||. .. |   ... | |.. 
wnp........n.srgvsyvfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkk

PPP_5_Dcr2 81-298 1.1e-48 158.9 In-house 1-197 (199) alignment
Range on Protein: 81-298
Range on HMM: 1-197/199.0
VTVIGDVHGNFHDLYRALLARTeqdiT---DeqksnfstrqfvRDKYVFLGNYIDKGPRSIECICLLFAFKICFPQKYILLRGPHECPSVNSseFLGVME
|||.||.|| ..||   |. .                      ...|||||.|.|.|..|.|...||.|.|. .|....|||| ||. ..|.  . |. .
vtvcGDlHGqlddlllilfkeg....gdpse............erlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlne..iygftk

-TFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEDPLATDL-LFADTLdfdlihipTRKPKYEFNVIRNMSVM
   |. | ||| |.... |.|.||||.. .|.|.||||.|| . |.|...||.|. .  .|.    || |..|           .. ..  | .|  ...
evlskyhgkkiykilsdvfdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdpr........daqegcklnseRGagll

YNEAAVTQFCEKFNLKLIIRSHM
... .. .|.|| ||||||||| 
fgpdvtekfleknnlkliirshe

subfamily_PPPLV_pd Subfamily PPPLV 59-344 3.5e-48 157.4 In-house 4-285 (290) alignment
Range on Protein: 59-344
Range on HMM: 4-285/290.0
SVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDL--YRALLARTEQDITDeqkSNfstrqfvrdkYVFLGNYIDKGPRSIECICLLFAFKICFPQKYI
|.|   .| . .|..|.|. .|. |.||.|||..||  .   | ||  |.|    ..          ..|||.|.|.|. |.| |. |.| |. .| |..
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltp...as..........llflgdyvdrgdfsveliayllalkvlypskvl

LLRGPHECPSVNSS-EFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTS---WEDIRKIKRPLKDATE-DPLATDLLFADTL-
|||| ||  ||  | |. |       ...... . ||..| ..|||||. .|..|||.||     .      |..|   |||  .  ||| |.|..|   
llrgnhelesvqesieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpae

--DFDLIHIPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNESNYGAVLKIDgNAKITIISL
  |  |    . .  . .|  |  . .. |.|. .| .. ||. ..|.|     |.|.  . ||.|.| |. .   ||  |.. .| . |. ||. 
drdlslrgelvlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalilvd.kkklriitt

PPP_4 81-298 1.2e-47 155.5 In-house 1-195 (197) alignment
Range on Protein: 81-298
Range on HMM: 1-195/197.0
VTVIGDVHGNFHDLYRALLArTEQDITDEqksnfstrqfvrDKYVFLGNYIDKGPRSIECICLLFAFKICFPQKYILLRGPHECPSVNSseFLGVMETFS
|||.||.|| ..||   ||  .  . ..|            ..|||||.|.|.|..|.|...||.|.|. .|....|||| ||. |.|.  . |  . . 
vtvvGDiHGqlddlllkllk.ngglpsee............rsyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnl..lygfkkevl

PNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEDPLATDLL-FADTLdfdlihiptRKPKYEFNVIRNMSVMYNEA
  | |.| ||... |...||||.. .|.|.||||.|. |.|...|..|.|. .  .|. .. ||| ..|           .. .   | .| ..... . 
ekhgkeilkklqdvfdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpr.........eaqeglansvrGagllFgpd

AVTQFCEKFNLKLIIRSHM
....|.|| ||||||||| 
vtekfleknnlkliirshe

subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 50-347 1.9e-47 155.0 In-house 4-275 (280) alignment
Range on Protein: 50-347
Range on HMM: 4-275/280.0
NNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlarteqDITDeqksnfstrQFVRDKYVFLGNYIDKGPRSIECICLLFAFKI
| ..  |. .. | |   | .| || |  ||. ||||.| ...|. | .      |.           .   .| .|||.|.|.||. || . |||..||
nvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlf......dlig.........rvpeeklmflgdyvdrgpqgievlillfclki

CFPQKYILLRGPHECPSVNSSefLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKdATEDPLATDLLFADt
 . ..  |||| || ||||     |.      ..   .   |. .|  ||..... ...||.|||.|| |   . ||.| || .   .  |  |||..| 
ryrdriyllrgnhetpsvnki..ygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpce.pldrgllidllwsd.

ldfdlihiPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE-SNYGAVLKIDGNAKITIISLLPQ
        || | .  |  || .| |. .. | | |. ... ||||.|  |  || ... .||||.|.   .  . .|  ||. .. | ....  |.| 
........ptnkgegwfhsirgisymfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp

subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 56-324 3.8e-45 147.4 In-house 27-271 (297) alignment
Range on Protein: 56-324
Range on HMM: 27-271/297.0
EVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRaLLARTEQDITdeqksnfstrqfvrDKYVFLGNYIDKGPRSIECICLLFAFKICFPQKY
 |  .    .| ||......|| ||. | ||.||.| || | |. |     |               .|.|||.|.|.|  ||| | ||.|.|. || ..
rvlklldlaldvfkaqksmvevnapikvcgdihgqfpdllr.lfhrggwppt..............anylflgdyvdrgrfsietivlllaykvkfpgnl

ILLRGPHECPSVNSSefLGVMETFS-PNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLT---SWEDIRKIKRPLkDAtEDPLATDLLFADTLD
.|||| |||  ||     |. |      .  ...  |.. | |.||. .. .||||.|||.|| ||   . . .|||.|.  .  .. | .|||.|| . 
fllrgnhecefvnkv..ygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierst.eg.kerlvadllwadpis

fDLIHIptrkpkyeFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE
  |  .        ..  |   . .   || . | .|.| |. |.|  |  || ||. ..|.||| .  .  .
.glsgf........menqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgq

subfamily_PPP4C_pd Subfamily PPP4C 50-338 7.4e-45 146.4 In-house 14-276 (288) alignment
Range on Protein: 50-338
Range on HMM: 14-276/288.0
NNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlaRTEQDITDEqksnfstrqfvrdKYVFLGNYIDKGPRSIECICLLFAFKI
. .. .|| ..|. . . . .| |. .| .|||| ||.||.|.|| . .  .   |. ..             .|.|||...|.|  |.|.. || |.|.
elikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelf..kvggdvpet.............nylflgdfvdrgfysvetfllllalkv

CFPQKYILLRGPHECPSVNSSefLGVM-ETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPlKDATEDPLATDLLFAD
 .|..  |.|| ||. ..  .   |   |. .     .. .   | | ...|||.. .||.|||||.|| ... ..|| | |  ..  ..   .|||..|
rypdritlirgnhesrqitqv..ygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrk.qevphegplcdllwsd

TLDFDLIHIPTrkpkyefnviRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQN-ESNYGAVLKIDGNAK
  | .   .            |    .. . .|.||.|. ...||.|.|  |  ||..  .....|.. .  .     |  |.|..| ...
pedaegwavsp..........rgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeld

subfamily_PPP6C_pd Subfamily PPP6C 49-337 1.3e-43 142.2 In-house 12-274 (290) alignment
Range on Protein: 49-337
Range on HMM: 12-274/290.0
KNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRalLARTEQDITDeqksnfstrqfvrDKYVFLGNYIDKGPRSIECICLLFAFK
 . |. |..  .|  |.| . .| |.. ||.|||| ||.||.|.||    | ||  .. |             ..|||||...|.|  |.| . .|...|
ckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydlee..lfrtggqvpd.............tsyvflgdfvdrgyysletftrlltlk

ICFPQKYILLRGPHECPSVnsSEFLGVM-ETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEDPLaTDLLFA
. .|.. .|||| ||.  .  ..  |   | ..     . .| . . |  ...||.. ...||||||.||...  ..|| |.|  . . . .. .||...
akypdritllrgnhesrqi..tqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgaf.cdlvws

DTLDFDLIHIPTRKPKYEFNVI--RNmsvmyneaavtqFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQN-ESNYGAVLKIDGNA
|  | .  .. .|   | |     ..            |..  |||||.|.|  |  |.... ...|.|.. .  .     |  ..|... . 
dpedvetwavsprgagylfgskvtke............fvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledae

subfamily_PPP2C_pd Subfamily PPP2C 49-343 1.4e-42 138.8 In-house 14-282 (290) alignment
Range on Protein: 49-343
Range on HMM: 14-282/290.0
KNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRalLARTEQDITDeqksnfsTrqfvrdKYVFLGNYIDKGPRSIECICLLFAFK
 ..|. .|| ..|  . . ..||.|. ||..||||.|||||.||||    | .   .  |       |      .|.|||.|.|.|  |.|...|| |.|
ckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdlle..lfkiggkspd.......t......nylflgdyvdrgyysvetvtllvalk

ICFPQKYILLRGPHECPSVNSseFLGV-METFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEDPLaTDLLFA
. ....  .||| ||   .      |   | .      .. | | . | ..||.|.| ..|.|.|||.||.... ..||...|  .   | || .|||..
vrykeritilrgnhesrqitq..vygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegpl.cdllws

DTLDFDLIHIPTRKPKYEFNviRNMSvmyneaavTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE-SNYGAVLKIDGNAKITIIS
|  | .   |  |   | |   ...|         .| .. .|.||.|.|  |  ||..  .....||| .  . .   | .|.|..| . | ... 
dpddrggwgisprgagytfg..kdis........ekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflq

subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 59-352 4.4e-41 134.0 In-house 27-297 (307) alignment
Range on Protein: 59-352
Range on HMM: 27-297/307.0
SVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALLARTEQDITdeqksnfstrqfVrdkYVFLGNYIDKGPRSIECICLLFAFKICFPQKYILL
 |       |  |. |...  |. |.||.||.| ||   ..       |            |   ||| |.|.|.|  |.||| |||..|||.|.. .||
nviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppet............v...yvftgdyvdrgllslecilllftykicypenivll

RGPHECPSVNSS-EFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEdPLATDLLFADTlDFDLihi
|| ||   ||    |     |  |.  ..|   |. .|  .|..|..  ||||.|||.|| ||  ...|.  .|...     .  |.|.||  |  .   
rgnheiarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfr.givndmlwadp.dpsv...

ptrkpkYEFN-VIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQN-ESNYGAVLKIDGNAKITIISLLPQQSKAE
      .|..   |   . .    . . | .. ..||||.|  .  ||  .| ..||||| .  . |   | |.|||.|    | .....|.  . |
......fewkassrgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpesenie

subfamily_PPP5C_pd Subfamily PPP5C 32-338 1.8e-40 131.9 In-house 18-299 (322) alignment
Range on Protein: 32-338
Range on HMM: 18-299/322.0
FEFLKKMIQpgrVMKrSKNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAP----VTVIGDVHGNFHDLYRALlarteqditdEQKSNFSTrqfvRDKYVFL
 ||.|....    .| ....|    . ..   . . .||.  |.|.. .    .|| ||.||.|.||.  .          | .   |.    .. |.| 
kefvkelle...lfk.kqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnif..........elnGlpse....enpylfn

GNYIDKGPRSIECICLLFAFKICFPQKYILLRGPHECPSVNssEFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISP-RLTSWEDIR
|...|.|  |.|.| .|..||. .|... | || ||  ..|  .. |  .     . .|. . |.| |.|.||| |. .|.| ||||.      . .|.|
GdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmn..klyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlr

KIKRPLKDATEDPLaTDLLFADtldfdlihiPTRKPKyEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQ-NES
||.|  .. .|. |  .||..|         | ...    .  | ..| .     ..|... ||.||||||     ||..  . .|||.| .  .  . .
kidrnaqppeegll.vellwsd.........pqeanG.rspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmg

NYGAVLKIDGNAK
| ||.... |. .
nkgafitlrgddl

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 122-347 2.2e-40 131.8 In-house 120-334 (339) alignment
Range on Protein: 122-347
Range on HMM: 120-334/339.0
DKYVFLGNYIDKGPRSIECICLLFAFKICFPQKYILLRGPHECPSVNSSefLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTS
 .|.|||.|.|.|| |.| . || |.|...|..  |||| ||  |||.|   |.       .  .... |.. |  .|..||. . |.|.||||| .|||
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvnts..ygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehlts

WEDIRKIKRPLKdATEDPLATDLLFADTldfDlihiPTRKPkYEfNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGF
....  .||||.   .  . ||| .||    |    || |  |.    |  |...   |.  | .|..|...|| |  |  || ||  .||.||| .  .
fnqfsvfkrple.ipdvgvltdltwadp...d....ptekg.yk.psargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapny

Q-NESNYGAVLKIDGNAKITIISLLPQ
  .. |  ||. || . ||.|  . |.
cgqndntaavfsidkklkisinvfrpe

subfamily_PPP7C_pd Subfamily PPP7C 47-347 5.5e-38 123.7 In-house 28-335 (383) alignment
Range on Protein: 47-347
Range on HMM: 28-335/383.0
RSKNNLSSNEVWSVCRAVIDEFKKEQNLMEVS----APVTVIGDVHGNFHDLYRALlarteqditdeQKSNFSTrqfVRDKYVFLGNYIDKGPRSIECIC
. |. | .. |  . |   ...|. .|. .||      ||| ||.||.. ||   |            |  . .    .. ||| |...|.| .|.| ..
kekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllil...........yknGlps...eenpyvfnGdfvdrGkesveill

LLFAFKICFPQKYILLRGPHECPSVNSS-EFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRlTSWEDIRKIKRP-LKDATEDPL
.|.|. . .|..  | || ||   .|    |.  .|.  ..| ||| . ... |.|.|||... .||| |||||| . |. | . ||.|  |.   . ||
illalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdk.tdlelldkiersklvsvlrppl

ATDL----------LFADTLD----FDLI-HIPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTG-FQNE
 ..           .  |. .    .|..   |  |     |..|   . .     ... .|.||||.||||   | || |  .|...||| ..  ... 
kegeeaekekeessvkvdkeewrqvldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeG

SNYGAVLKIDGNAKITIISLLPQ
|| || .|.  . .  |.    .
snrGayvklgkdltprivqyqas

subfamily_PPG1_pd Subfamily PPG1 56-324 1.1e-35 116.4 In-house 18-272 (300) alignment
Range on Protein: 56-324
Range on HMM: 18-272/300.0
EVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlaRTEQDITDeqksnfsTrqfvrdKYVFLGNYIDKGPRSIECICLLFAFKICFPQKY
 | ...  . . . || |..|. .||||.|||||.|.|.   .  .   .. |       |      .|.|||.|.|.|  |.| | || ..|. .| . 
tvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleif..kiggqvpd.......t......nylflgdyvdrglysvetisllivlklrypsri

ILLRGPHECPSVNSS-EFLG-VMETFSPNhfKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRpLKDATEDPLATDLLFADTL--D
 |||| ||   .  .  | . ... .. |   .. | . | | .. |||.. ..| |||||.||   | ..|. . | ...  ..   .|||..|    .
tllrgnhesrqitqvygfyteclrkyggn..srvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldr.frevpnegaladllwsdpeenn

FDLIHIPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE
   .. | |. ..  .  |     | .  | .| .. ... |||.|  .  ||. . ...| |.. .  . . 
nptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyr

Metallophos Calcineurin-like phosphoesterase 80-298 4.4e-32 105.0 Pfam-A 2-197 (200) alignment
Range on Protein: 80-298
Range on HMM: 2-197/200.0
PVTVIGDVHGNFHDLYrallarteqdItDEQKSNFSTRQFVRDKYVFLGNYIDKGPRSIECICLL--FAFKICFPQKYILLRGPHECPSVNSSEFLGVME
...||||.||...||.          . .. . .    .   | ..||| ..| |..|.|...||  .. |. .| ...|||| ||....||        
rilvigDlHgglddle..........d.lllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleq

T--------------------------------FSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIrkikrplkdatedplatdll
                                 . |......  ...| | ..||.| |..|||..||..|... |..||                    
lkdlrglangeeeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi....................

fadtldfdlihiptrkpkyefnvirnMSVMYNEAAVTQFCEKFNLKLIIRSHM
                           |. ... |.  ..|| ...|..|.| 
..........................gselfgpdalekllekygvdlvlrGHt

subfamily_YNL217W_pd Subfamily YNL217W 81-218 8.8e-06 18.4 In-house 12-139 (235) alignment
Range on Protein: 81-218
Range on HMM: 12-139/235.0
VTVIGDVHGNFHDLYRaLLartEQDITDEQkSNFStrqfvrdkYVFLGNYIDKGPRSIECICLLfafkicFPQKYILLRGPHECPSVNSSEFLGVMETFS
. |.|||||.. .| . ||   .. | . .  |           |..|. |.|||.|.| . ..        ..   ..| ||   . . ...   . . 
llvvGdvhgaYDelie.Ll...ddkiggkd.envl........vvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgae

PN----HFKKI-HKKFNEAFSW---MPLA-AVVGQKILCVHGGISPR
|     .|. . .|  ..  ..   .. .  . ....| ||.|..| 
plefsskfsflesklskadmeyarelgfsldipsdellvvhaGlvpg