Gene ZC477.2 in Caenorhabditis elegans

Synonym: CELE_ZC477.2, ZC477.2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf5
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP233_AA protein Get Run
CeleP233_AA_45-348 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 48-348 3.5e-153 502.1 In-house 2-301 (302) alignment 
Range on Protein: 48-348
Range on HMM: 2-301/302.0
SKNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALLARTEQDiTDEQKSNFStrqFVRDKYVFLGNYIDKGPRSIECICLLFAF
.|...|..|......|||...|||..|.|.|.|||..||.||.|.||.|.|.||.... ....||..|   |..||.||||.|.|.|..|||||||.||.
rkkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvske.eakkksays...fssdkfvflGdyvdrGsksieciclvfal

KICFPQKYILLRGPHECPSVN-SSEFLGVMET-FSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEDPLATDLL
|...|..||||||.||....| ...| ...|. ......|.|..||||.||.|||||.||.|||||||||||.|.|.|||.|||||||..|||.||.|||
kvlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdll

FADTLDFDLIHIPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNES-NYGAVLKIDGNAKITIISL
|||.||..|......||||..|..|..||..|||||...|...|||||.|.|...|.|..||..|.|.|||......||| |.|||||.|.|.|..|..|
fadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvl

LPQQ
 ...
rnkk
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 46-347 1.7e-152 499.9 In-house 1-301 (302) alignment 
Range on Protein: 46-347
Range on HMM: 1-301/302.0
KRSKNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALLARTEQDiTDEQKSNFStrqFVRDKYVFLGNYIDKGPRSIECICLLF
|..|...|..|......|||...|||..|.|.|.|||..||.||.|.||.|.|.||.... ....||..|   |..||.||||.|.|.|..|||||||.|
kyrkkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvske.eakkksays...fssdkfvflGdyvdrGsksieciclvf

AFKICFPQKYILLRGPHECPSVN-SSEFLGVMET-FSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEDPLATD
|.|...|..||||||.||....| ...| ...|. ......|.|..||||.||.|||||.||.|||||||||||.|.|.|||.|||||||..|||.||.|
alkvlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqd

LLFADTLDFDLIHIPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNES-NYGAVLKIDGNAKITII
|||||.||..|......||||..|..|..||..|||||...|...|||||.|.|...|.|..||..|.|.|||......||| |.|||||.|.|.|..|.
llfadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsis

SLLPQ
.| ..
vlrnk
PP2Ac_SM00156 53-347 6e-101 330.0 In-house 2-270 (271) alignment 
Range on Protein: 53-347
Range on HMM: 2-270/271.0
SSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlarteqditdeqksnFSTRQFVRDKYVFLGNYIDKGPRSIECICLLFAFKICFP
|..||......|.. .|.|.||.||||||||.||.||...||.| |                ..... ..||||||.|.|.||.|||.|.||||.||..|
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrll...............elageppeekyvFlGdYVDRGpqsiEvillLfalkilyp

QKYILLRGPHECPSVNssEFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRpLKDATEDPLATDLLFADTldf
.|..|||| ||..|||  .. |..|... .. |.|..||.||||..||||.|..||||.|||.||.|.|..||||.||  |. .|..|..|||..|.   
ekvvLLRGnHEsssvn..kiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkr.vkekpeegllidllwsdp...

dlihiPTRKPKYEFNViRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE-SNYGAVLKIDGNAKITIISLLPQ
      .........  |..||...|.||..|..|.|||||||.|. |. ||.||..|.|.|||... ...| ||..||||.. |.|..|..| .|
.....eqkekgfqpsk.rglsvvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
0045823 Metallo-dependent phosphatases 48-348 5.9e-76 249.0 In-house 39-325 (473) alignment 
Range on Protein: 48-348
Range on HMM: 39-325/473.0
SKNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRaLLARTEqdiT---DeqksnfstrqfvrdKYVFLGNYIDKGPRSIECICLL
  . |. ........ ... .||| || |.|....||||.||...|| | ||.. .       |              ..||||...|.|| |.|...||
kegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlr.llekig...fpped..............rlvflGDlvDrGpdslevlell

FAFKICFPQKYILLRGPHECPSVNSSefLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLkDATEDPLATDL
.|.||..|.. .|||| ||.  .|    .| ....      .. . |.| ....|||||.|.|||.||||.|| |.....||.|.||| .  .|.|..||
lalkikypgnvfllrGNHElrllngl..ygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpl.eipddgllldl

LFADTlDFDLIHIPTRKpKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKR------LITIFNSTGFQN-ESNYGAVLKIDGNA
|..|. . |  .  .|   .  |  |........ || .|..|..|.||.|.|  || ||...  ..      .||.| .. . .   | .|||.||.. 
lwsdP.weddgdgllrl.rffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl

kITIISLLPQQ
 |..| . | .
.isfiqfdpsp
subfamily_PPP1C_pd Subfamily PPP1C 47-347 7e-71 231.7 In-house 5-279 (282) alignment 
Range on Protein: 47-347
Range on HMM: 5-279/282.0
RSKNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALLARTEQDITdeqksnfstrqfvrdKYVFLGNYIDKGPRSIECICLLFA
... .|...|. .....  . ....  |.|..|||...||.||...|| | . .    . .               .|.|||.|.|.| .|.| |.||.|
gkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpes...............nylflGdyvdrGkqsletivllla

FKICFPQKYILLRGPHECPSVNSseFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLkDATEDPLATDLLF
.|| .|..  |||| ||. |.|   . | ..     . .|. |.|...|...||||.| .||||||||.||.|.| |.||||.||| .  |. |..|||.
ykikypenlfllrGnhesasinr..iyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPl.evpekgllcdllW

ADTlDFDLIhiptrkpKYEFNViRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQN-ESNYGAVLKIDGNAKITIISLL
.|  | .         ... |  | .|. ... .|..|..|..|.||.|.|. |  ||.||....|.|.| .. . .   | ||||..| . ...   | 
sdp.dkevl.......gwsend.rGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilk

PQ
|.
pa
0049330 Metallo-dependent phosphatases 46-348 1.7e-68 224.1 In-house 24-300 (309) alignment 
Range on Protein: 46-348
Range on HMM: 24-300/309.0
KRSKNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRaLLARTEQDitdeqksnfstrqFVrDKYVFLGNYIDKGPRSIECICLLF
 .    || .|.. ..  ... .|.| ||.|.|....||||.||...|| | ||.. . .              . |..||||...|.|| |.|...||.
llklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlr.llekigfp.............pe.drlvflGDlvdrGpdslevlllll

AFKICFPQKYILLRGPHECPSVNSSefLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEdPLATDLL
|.|...|.. .|||| ||.  .|    .| ....      .. ..|.. ....|||||.|.||||||||.|| |.....||...|||    . .| .|||
alkllypdnvfllrGNHElrllngl..ygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipld.gllcdll

FADTLDFDLIhiptrkpkYEFNViRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQN-ESNYGAVLKIDGNAKITIISL
..| |..           .  |. |...| ... || .|..|..|.||||.|  |. ||..| ...|||.|... . .  .|.||||.||.. .|... .
wsdplpireg........fapnp.rglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllf

LPQQ
 | .
epvp
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 35-349 1.6e-67 220.6 In-house 7-296 (298) alignment 
Range on Protein: 35-349
Range on HMM: 7-296/298.0
LKKMIQPGRVMKRSKNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlARteqditdeqkSNFSTRQfvrdKYVFLGNYIDKG
| .... .   |.  . .....| .... . . ||| . |.|| ||..| ||.||.. || | . ..          ..|  ..     |.|||.|.|.|
lievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlf.dk..........agfppda....nylflGdyvdrG

PRSIECICLLFAFKICFPQKYILLRGPHECPSVNSSefLGVMET-FSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLk
  ..| |.||.|.|. .|....|||| |||...|     |  |      .  .....|...|...||.|..|..|||.|||.|..|.|....|..|||  
rqnlevivlllaykvkypnnffllrGnheceainrv..yGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpf.

DATEDPLATDLLFADtldfdlihiPTRK-PKYEFNvIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE-SNYGAVL
|. |. ||.|||.||         |...   .. |  | .||.. | .| ...||... |..|.|  |  || ||.||.|.||| .  . ..  |  ||.
dskeeslaidllwad.........penavkgwaen.srGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavm

KIDGNAKITIISLLPQQS
|.| . ...   | |.. 
kvdeklvvsfevlkpekk
PPP_3 52-339 3.2e-67 219.4 In-house 2-264 (271) alignment 
Range on Protein: 52-339
Range on HMM: 2-264/271.0
LSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLyrALLARTEQDITDeqksnfstrqfvrDKYVFLGNYIDKGPRSIECICLLFAFKICF
||.||. .... . . ..||.||.|.||||||.||.|| ..||    | .. ... .              ||.|||.|.|.|  |.|...||.|.|| .
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDL..lelfknggpspe.............tkYlFlGdyVDrGkkslEvlllLlalkiky

PQKYILLRGPHECPSVNSSeFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEDPLATDLlfadtld
|.. .|||| ||. ..|.  .    | ..  . ||..||..| |...||||.. .|.|.||||.||...|...|.|..|. .  .| .| ..|       
pkevhLlRGnhEsrqinkv.YgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldll.......

fdlIHIPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGF-QNESNYGAVLKIDGNAKI
   .  ...| .   |  | ..... . ....|.|| .||||||.|  .. ||... .....|.|  . . .. || ||.||.. ... 
...lssdpekeeglenskrGagllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealts
0053225 Metallo-dependent phosphatases 50-345 2.7e-65 213.7 In-house 20-289 (293) alignment 
Range on Protein: 50-345
Range on HMM: 20-289/293.0
NNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlARTEQDitdeqksnfstrqFVrDKYVFLGNYIDKGPRSIECICLLFAFKI
  || .|.. ..  ... .|||.||.|.|....||||.|||..|| . | .. . .              . |..||||...|.|| |.|...||.|.|.
kllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlall.ekigfp.............pe.drlvflGDlvdrGpdslevlelllalkl

CFPQKYILLRGPHECPSVNSSEFlGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEdPLATDLLFADT
..|.. .|||| ||.  .|     .  ||.   . ... . ... ....||||..|.|||.||||.|| |.....||.|.|||   .| .| .|||. | 
lypdnvvllrGNHElmllnglyg.fgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriple.gllldllwsdp

LDFDLIHIPTrkpkyefnviRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQN-ESNYGAVLKIDGNAKITIISLL
 ... ...            |...| ... || .|..|..|.||||.|  || ||... ...|.|.|... . .  .|.||||..|.. ..... . 
dlwsgwlpsy..........rglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfa
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 51-349 7.2e-65 211.7 In-house 9-284 (287) alignment 
Range on Protein: 51-349
Range on HMM: 9-284/287.0
NLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlarteQDITDEQKSnfstrqfvrdKYVFLGNYIDKGPRSIECICLLFAFKIC
..| .....| . . . ..  . |.|| ||.|..||.||...|| | .     ...    |           .|.|||.|.|.|..|.| . |||..|| 
afsdkdilevlekieeileplpalleveapitivGdihGqlddllrif.....navGaapkv..........qylflGdyvdrGakslevslllfslkia

FPQKYILLRGPHECPSVNSseFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDAT-EDPLATDLLFADt
.|.|  |||| ||.  .|     |  | .  .. ....|.||. || .|| | |...|||.||||||.| |..... .|.| .. . .. |  |||.|| 
ypkkvhllrGnhevkkink..lyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwad.

ldfdlihiPTRK-PKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQ-NESNYGAVLKIDGNAKITIISLLPQ
        |...   .|.| || .||.. .  | ....|....||.|.|  .  || |. .|||.|.| .. .. ...|.|||....   ..... | |.
........pekdaktfelnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpe

QS
. 
df
PPP_1 53-332 1.6e-61 200.9 In-house 2-263 (264) alignment 
Range on Protein: 53-332
Range on HMM: 2-263/264.0
SSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLyRALLarteqditdeQKSNFSTrqfvRDKYVFLGNYIDKGPRSIECICLLFAFKICFP
...|. .... . . ..||.||.|||...||.||.||.|.||   |           ... .|     . .|.||| |.|.|  |.|...||.|.|. .|
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDL.lklf..........kvggpsp....etnYlFlGDyVDRGkdSvEilllLlalklkyp

QKYILLRGPHECPSVNSSeFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKdATEDPLATDLLFADTLdf
..  |||| ||. .|..  .    |    .. |.|.| . ..| ..||||.. .|||.||||.|| |.. ..|||..|  .  .|.  ..||| .|.   
kelfllRGNHEsrqvtkv.ygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrkte.vpeegklcdllekdvd..

DLIHIPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNS-TGFQNESNYGAVLK
.|.. .... .   | || .. .... ....|..|.|||||||.|. .. ||.|.......||| . . ... || ||..|
illsddkeqeeavansiRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 46-347 9.2e-61 198.7 In-house 3-315 (317) alignment 
Range on Protein: 46-347
Range on HMM: 3-315/317.0
KRSKNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALLAR----TEQDIT-----------DEQKSNF-------STRQFVRDK
|.... ....|.  .|    . | ||.  .|. ||||..||.||.|.||   |       ..|.             .. |...         ..  ..|
kkcqdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwplssqeeksepkslllesskdvkqtvaavksvnkevtkgykk

YVFLGNYIDKGPRSIECICLLFAFKICFPQKYILLRGPHECPSVNSSefLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWE
|.|||.|.|.|| ||| . ||||.|. .|.| .|||| ||  .|| .   |  .     . ..... |. ||  .||.|||..||||.|||||  |.. .
ylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntq..yGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

DIRKIKRPLkDATEDPLATDLLFADtldfdlihiPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQ-
 . |.|||| | ..  . .|| .||         |  . |.  .  |  . .. ..|| .|..|..|.|..|.|  |  || ||....|.||| .  .  
qldklkrpl.dipdvGvladltwad.........pdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycG

NESNYGAVLKIDGNAKITIISLLPQ
.  | .|||..| . ||.|  | |.
qldniaavlsvdkklkisinvlrpe
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 49-343 5e-60 196.3 In-house 5-279 (284) alignment 
Range on Protein: 49-343
Range on HMM: 5-279/284.0
KNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALLARTEQDITDEQKSnfstrqfvrDKYVFLGNYIDKGPRSIECICLLFAFK
.. |. .|.  .|    . | ||.  .|. |||...||.||.| ||   |       ..||.|.         .||.|||.|.|.|| ||| | ||||.|
qkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeake.........kkylflgdyvdrgpfsievitllfayk

ICFPQKYILLRGPHECPSVNSSefLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLkDATEDPLATDLLFAD
. .|.| .|||| ||   ||     | ..     . ..... |. ||  |||.|||..||.|.|||||  | . ... |..||. | ..  . .|| .||
lllpdkvfllrgnhesrpvnmq..ygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpi.dipdigviadltwad

tldfdlihiPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQN-ESNYGAVLKIDGNAKITIIS
         |  . ..  .  |    .. ..|| .|..||.|.|..|.|  |  || ||....|.||| .  .     | .|||..| .  ...  
.........peaevegykesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftv
subfamily_PPP3C_pd Subfamily PPP3C 50-337 4.4e-57 186.8 In-house 39-313 (452) alignment 
Range on Protein: 50-337
Range on HMM: 39-313/452.0
NNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALLarteqdiT-DeqksnfstrQFVRDKYVFLGNYIDKGPRSIECICLLFAFK
 .|.....  . . . . .|||..|.||.||.|||||.|| |.|| . .                    .    ||.|||.|.|.|  ||||.  |.| |
grleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfe.......vgG.........dPastkylflGdyvdrGyfsiecvlylyalk

ICFPQKYILLRGPHECPSVnsSEFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRpLKDATEDPLATDLLFAD
|..|... |||| |||  .  .|..   |     . ....... |.|  .||||.. |. ||||||.|| ..| .||.|..| .|.  .  .  |||..|
iaypstlfllrGnhecrhl..teyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldr.fkeppasGplcdllWsd

TLD-FDLIHiptRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSE------KRLITIFNSTGFQN-ESNYGAVLKIDGNA
 |. ..  .    . |.  | .|  |..|. .||..| .| .|  |||.|     ||| . .        |||.| .. . .  .| .||||.. | 
Pledygeek...teekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennv
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 57-346 1.7e-56 184.4 In-house 11-274 (280) alignment 
Range on Protein: 57-346
Range on HMM: 11-274/280.0
VWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRaLLARTeqditdeqksNFSTRQfvrdKYVFLGNYIDKGPRSIECICLLFAFKICFPQKYI
. .| . . . .. .. ..|| |||.| ||.||.. || | |.||.          .|   |    .|.|||.|.|.|   .| |.||.|.|. .|....
idrviekckkiltaqatmvevdapvavcgdlhgqytdllr.lfarv..........sfppdq....nylflgdyvdrgrqqlevillllaykvrypnnfl

LLRGPHECPSVNSSefLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLkDATEDPLATDLLFADtldfdlih
.||| ||. |.|     |  .     . ......|.| .  .||.|.|. .|||.|||.|..| |..|.....||. |. .. ||.|||.||        
ilrgnhevisinrk..ygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpf.dsedeclamdllwad........

iPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE-SNYGAVLKIDGNAKITIISLLP
 |  |     .  | .||.. .  | ...||... ||.| |  |  || ||..|.|.|.| .  . .| .|  |||..| . ....  | |
.penkvtgwaensrgvsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkp
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 34-349 2.5e-56 184.1 In-house 6-296 (299) alignment 
Range on Protein: 34-349
Range on HMM: 6-296/299.0
FLKKMIQPGRVMKRSKNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlarteqditdeQKSNFSTRQfvrdKYVFLGNYIDK
.| |... |   ||  ...  .|. ..|.   . | ..  |.|| ||. | ||.||.. || | .           .|..|        ...|||.|.|.
llskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrif...........dkagfppdv....nflflgdyvdr

GPRSIECICLLFAFKICFPQKYILLRGPHECPSVNSseFLGVMETFS-PNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPl
| . .| |.||..||| .|... .||| ||||..|     |  |      .  ..   |..||..|||. ..| .|||.|||.||.|.. . .|.. || 
grqnlelitlllcfkikyperffmlrgnhecpainr..vygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrp.

KDATEDPLATDLLFADTLDFdLIhiptrkpKYEFNvIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE-SNYGAVL
.|  .  |  |||.||  .. ..       ..  | .| .| .. .  |.. ...... |. |.|  |  || ||..|.|.||| .  .  .  |  |..
qdppnpslgidllwadpdqs.vk.......dwlan.vrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaim

KIDGNAKITIISLLPQQS
|.| |   |.  | | . 
kvdenlvctfvvlkptpk
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 52-348 8.1e-56 182.3 In-house 8-278 (281) alignment 
Range on Protein: 52-348
Range on HMM: 8-278/281.0
LSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlarteqDITDeqksnfstRqFVRDKYVFLGNYIDKGPRSIECICLLFAFKICF
.. .|. .| | |   | .|..|.|. .|..|.||.|..|.|| |..      .. .        |   ....||||.|.|.||.|.|.. |||..||..
ytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlf......ellg........r.vpeevlvflgdyvdrgpqslevlillftlkiry

PQKYILLRGPHECPSVNSSefLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATeDPLATDLLFADtld
... .|||| || .|||     |  .       ...  .|.. |  .|..| . ...||.|||.|| ||. ...|.. .|...     |  |||.||   
rdrivllrgnheiasvnki..ygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnld.rGlviDllwad...

fdlihiPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE-SNYGAVLKIDGNAKITIISLLPQQ
      |. | .  .. .| .| .. .. | . | .... ||||.|  |  ||. .| ..|||.|    . .   | .||||.| . .|....|.|. 
......pdnkveewkassrGssftfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpas
subfamily_PPZ_pd Subfamily PPZ 33-337 1.1e-55 182.2 In-house 5-284 (300) alignment 
Range on Protein: 33-337
Range on HMM: 5-284/300.0
EFLKKMIQPGRVMKRSKNN-LSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlarteqdiTdeqKSNFSTRqfvrDKYVFLGNYI
| ..|... |   ||.||  |  .|.  .|    . |  . .|.|.| .| ..|||||.. || | .        |   |  |        .|.|||.|.
eiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlf........t...kcgfpps....anylflgdyv

DKGPRSIECICLLFAFKICFPQKYILLRGPHECPSVnsSEFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRP
|.| .|.| | ||...|| .|....|||| |||  |  .   |. .        || | | ..|  .||||.|  ||.|||||.|| | | ..||.. ||
drgkqsletillllcykikypenffllrgnhecanv..trvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrp

lKDATEDPLATDLLFADTLDfdlihiptRKPKYEFNvIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE-SNYGAV
  |  .  |  |||..|  |           ..| |  | .|  ||. |. .| .|| . |. |.|| |  || || .. |.|.|..  .  |  |.|||
.tdvpdfglindllwsdptd........ssnewedn.ergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgav

LKIDGNA
. .    
msvsegl
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 74-348 8.7e-55 179.2 In-house 2-257 (263) alignment 
Range on Protein: 74-348
Range on HMM: 2-257/263.0
LMEVSAPVTVIGDVHGNFHDLYRALLARTEqditdeqksnfSTrqfvRDKYVFLGNYIDKGPRSIECICLLFAFKICFPQKYILLRGPHECPSVNSSE-F
|.|. ||. . || ||.. || | . |              .|    . .|.|||.|.|.| .|.| | |||..|...|.|  |||| ||  ..|    |
llelqapinicgdthgqyndllrifnacga...........at....ktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygf

L-GVMETFSP-NHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEDPLATDLLFADTLDfDlihiptrKPKYEFNVIR
   . . |   . .. ....||. ||.|||.|.| ..|||.||||||.| | .||| |  ||. |   ||| |||.||    |          .| | ||
haelkkrfqreevyesvynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.d.......akgfepnkir

NMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE-SNYGAVLKIDGNAKITIISLLPQQ
 .| .. .  | ..|..... ||.|.|  | .|| ||...||||.|... .| |  || ||. ..   ..... | |..
aisnvfgkkevddlckrldidlivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkped
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 50-347 5e-54 176.3 In-house 14-289 (290) alignment 
Range on Protein: 50-347
Range on HMM: 14-289/290.0
NNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlarteQDITDEQKsnFstrqfvrdKYVFLGNYIDKGPRSIECICLLFAFKI
. .| ...... . . . ..    |.|| ||....||.||.. .| | .     ...    |  .        |..|||.|.|.|..|.|   ||| .||
dafsdkdileilekieeileplpalleveapivivgdihgqldallryf.....davgyppk..v........kflflgdyvdrgakslevslllfcyki

CFPQKYILLRGPHECPSVNSseFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDA-TEDPLATDLLFAD
 ...|  |||| ||.  ||   . |  | .      .. |.... |. ..| | ||.||||.|||||... ||| .. .|.|  .   .. |  |||.||
ryskkvhllrgnhevrkvnr..lygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwad

tldfdlihiPT--RKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGF-QNESNYGAVLKIDGNAKITIISLL
         ||  .   ...|  | .||.. . .. ....|. |.||.|.|     |. |  .|.|.|.| .  .  |..| ||....    ...|. | 
.........ptrdkddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlk

PQ
|.
pr
PPP_2 81-298 2e-50 164.3 In-house 1-196 (198) alignment 
Range on Protein: 81-298
Range on HMM: 1-196/198.0
VTVIGDVHGNFHDLyrALLARTEQDITDeqksnfstrqfvrDKYVFLGNYIDKGPRSIECICLLFAFKICFPQKYILLRGPHECPSVNSSeFLGVMETFS
|||.||.||...||    | .. .....              ||.|||.|.|.| .|.|...||.|.|. .|.. .|||| ||. .||.  .    | ..
vtvcGDlHGqldDL..lilfknglpspe.............rkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkv.ygFkkevlk

PNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEDPLATDLlFADTldfdlIHIPTRKPKYEFNVIRNMSVMYNEAA
  . ||..||..| |...||||.. .|.|.||||.|........|.|..|. .  .| .| ..|   .      .  |..| .   |  | ....... .
kkggkkvykklqevfelLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldll.eeek.....lsdpkekeellansarGagllfgpdv

VTQFCEKFNLKLIIRSHM
.....||..||||||.| 
teelleknklkliiRaHe
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 57-349 5.6e-50 163.3 In-house 8-276 (284) alignment 
Range on Protein: 57-349
Range on HMM: 8-276/284.0
VWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlarteqditdeQKSNFSTrqfvRDKYVFLGNYIDKGPRSIECICLLFAFKICFPQKYI
| ..   ... |.|.  |.|| .|. . ||.||.| || | .           .|  |      | .|.|||.|.|.| . .| | ||||.|. ||....
vetllfhafsifnkqpmlievnspinicgdihgqfsdllrlf...........dkngfph....ranylflgdyvdrgkhcletilllfaykvifpnhff

LLRGPHECPSVNSSefLGVMETFSPNHFK-KIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEDPLATDLLFADTLDFDLI
.||| |||  .|     |. |     . |  ... |.  || |||.|.|||.|||.|||.|  |    ..| ||||. .   . || |.|..|  .|.  
mlrgnhecslinki..ygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkg

HIPtrkpkyefNvIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE-SNYGAVLKIDGNAKITIISLLPQQS
  |        |  | .| ..   |. .. ..... |..|.|  |  || ||...||.||| .  .  .  |  ||. .. |   ... | |.. 
wnp........n.srgvsyvfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkk
PPP_5_Dcr2 81-298 1.1e-48 158.9 In-house 1-197 (199) alignment 
Range on Protein: 81-298
Range on HMM: 1-197/199.0
VTVIGDVHGNFHDLYRALLARTeqdiT---DeqksnfstrqfvRDKYVFLGNYIDKGPRSIECICLLFAFKICFPQKYILLRGPHECPSVNSseFLGVME
|||.||.|| ..||   |. .                      ...|||||.|.|.|..|.|...||.|.|. .|....|||| ||. ..|.  . |. .
vtvcGDlHGqlddlllilfkeg....gdpse............erlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlne..iygftk

-TFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEDPLATDL-LFADTLdfdlihipTRKPKYEFNVIRNMSVM
   |. | ||| |.... |.|.||||.. .|.|.||||.|| . |.|...||.|. .  .|.    || |..|           .. ..  | .|  ...
evlskyhgkkiykilsdvfdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdpr........daqegcklnseRGagll

YNEAAVTQFCEKFNLKLIIRSHM
... .. .|.|| ||||||||| 
fgpdvtekfleknnlkliirshe
subfamily_PPPLV_pd Subfamily PPPLV 59-344 3.5e-48 157.4 In-house 4-285 (290) alignment 
Range on Protein: 59-344
Range on HMM: 4-285/290.0
SVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDL--YRALLARTEQDITDeqkSNfstrqfvrdkYVFLGNYIDKGPRSIECICLLFAFKICFPQKYI
|.|   .| . .|..|.|. .|. |.||.|||..||  .   | ||  |.|    ..          ..|||.|.|.|. |.| |. |.| |. .| |..
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltp...as..........llflgdyvdrgdfsveliayllalkvlypskvl

LLRGPHECPSVNSS-EFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTS---WEDIRKIKRPLKDATE-DPLATDLLFADTL-
|||| ||  ||  | |. |       ...... . ||..| ..|||||. .|..|||.||     .      |..|   |||  .  ||| |.|..|   
llrgnhelesvqesieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpae

--DFDLIHIPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNESNYGAVLKIDgNAKITIISL
  |  |    . .  . .|  |  . .. |.|. .| .. ||. ..|.|     |.|.  . ||.|.| |. .   ||  |.. .| . |. ||. 
drdlslrgelvlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalilvd.kkklriitt
PPP_4 81-298 1.2e-47 155.5 In-house 1-195 (197) alignment 
Range on Protein: 81-298
Range on HMM: 1-195/197.0
VTVIGDVHGNFHDLYRALLArTEQDITDEqksnfstrqfvrDKYVFLGNYIDKGPRSIECICLLFAFKICFPQKYILLRGPHECPSVNSseFLGVMETFS
|||.||.|| ..||   ||  .  . ..|            ..|||||.|.|.|..|.|...||.|.|. .|....|||| ||. |.|.  . |  . . 
vtvvGDiHGqlddlllkllk.ngglpsee............rsyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnl..lygfkkevl

PNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEDPLATDLL-FADTLdfdlihiptRKPKYEFNVIRNMSVMYNEA
  | |.| ||... |...||||.. .|.|.||||.|. |.|...|..|.|. .  .|. .. ||| ..|           .. .   | .| ..... . 
ekhgkeilkklqdvfdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpr.........eaqeglansvrGagllFgpd

AVTQFCEKFNLKLIIRSHM
....|.|| ||||||||| 
vtekfleknnlkliirshe
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 50-347 1.9e-47 155.0 In-house 4-275 (280) alignment 
Range on Protein: 50-347
Range on HMM: 4-275/280.0
NNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlarteqDITDeqksnfstrQFVRDKYVFLGNYIDKGPRSIECICLLFAFKI
| ..  |. .. | |   | .| || |  ||. ||||.| ...|. | .      |.           .   .| .|||.|.|.||. || . |||..||
nvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlf......dlig.........rvpeeklmflgdyvdrgpqgievlillfclki

CFPQKYILLRGPHECPSVNSSefLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKdATEDPLATDLLFADt
 . ..  |||| || ||||     |.      ..   .   |. .|  ||..... ...||.|||.|| |   . ||.| || .   .  |  |||..| 
ryrdriyllrgnhetpsvnki..ygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpce.pldrgllidllwsd.

ldfdlihiPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE-SNYGAVLKIDGNAKITIISLLPQ
        || | .  |  || .| |. .. | | |. ... ||||.|  |  || ... .||||.|.   .  . .|  ||. .. | ....  |.| 
........ptnkgegwfhsirgisymfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 56-324 3.8e-45 147.4 In-house 27-271 (297) alignment 
Range on Protein: 56-324
Range on HMM: 27-271/297.0
EVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRaLLARTEQDITdeqksnfstrqfvrDKYVFLGNYIDKGPRSIECICLLFAFKICFPQKY
 |  .    .| ||......|| ||. | ||.||.| || | |. |     |               .|.|||.|.|.|  ||| | ||.|.|. || ..
rvlklldlaldvfkaqksmvevnapikvcgdihgqfpdllr.lfhrggwppt..............anylflgdyvdrgrfsietivlllaykvkfpgnl

ILLRGPHECPSVNSSefLGVMETFS-PNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLT---SWEDIRKIKRPLkDAtEDPLATDLLFADTLD
.|||| |||  ||     |. |      .  ...  |.. | |.||. .. .||||.|||.|| ||   . . .|||.|.  .  .. | .|||.|| . 
fllrgnhecefvnkv..ygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierst.eg.kerlvadllwadpis

fDLIHIptrkpkyeFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE
  |  .        ..  |   . .   || . | .|.| |. |.|  |  || ||. ..|.||| .  .  .
.glsgf........menqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgq
subfamily_PPP4C_pd Subfamily PPP4C 50-338 7.4e-45 146.4 In-house 14-276 (288) alignment 
Range on Protein: 50-338
Range on HMM: 14-276/288.0
NNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlaRTEQDITDEqksnfstrqfvrdKYVFLGNYIDKGPRSIECICLLFAFKI
. .. .|| ..|. . . . .| |. .| .|||| ||.||.|.|| . .  .   |. ..             .|.|||...|.|  |.|.. || |.|.
elikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelf..kvggdvpet.............nylflgdfvdrgfysvetfllllalkv

CFPQKYILLRGPHECPSVNSSefLGVM-ETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPlKDATEDPLATDLLFAD
 .|..  |.|| ||. ..  .   |   |. .     .. .   | | ...|||.. .||.|||||.|| ... ..|| | |  ..  ..   .|||..|
rypdritlirgnhesrqitqv..ygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrk.qevphegplcdllwsd

TLDFDLIHIPTrkpkyefnviRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQN-ESNYGAVLKIDGNAK
  | .   .            |    .. . .|.||.|. ...||.|.|  |  ||..  .....|.. .  .     |  |.|..| ...
pedaegwavsp..........rgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeld
subfamily_PPP6C_pd Subfamily PPP6C 49-337 1.3e-43 142.2 In-house 12-274 (290) alignment 
Range on Protein: 49-337
Range on HMM: 12-274/290.0
KNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRalLARTEQDITDeqksnfstrqfvrDKYVFLGNYIDKGPRSIECICLLFAFK
 . |. |..  .|  |.| . .| |.. ||.|||| ||.||.|.||    | ||  .. |             ..|||||...|.|  |.| . .|...|
ckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydlee..lfrtggqvpd.............tsyvflgdfvdrgyysletftrlltlk

ICFPQKYILLRGPHECPSVnsSEFLGVM-ETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEDPLaTDLLFA
. .|.. .|||| ||.  .  ..  |   | ..     . .| . . |  ...||.. ...||||||.||...  ..|| |.|  . . . .. .||...
akypdritllrgnhesrqi..tqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgaf.cdlvws

DTLDFDLIHIPTRKPKYEFNVI--RNmsvmyneaavtqFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQN-ESNYGAVLKIDGNA
|  | .  .. .|   | |     ..            |..  |||||.|.|  |  |.... ...|.|.. .  .     |  ..|... . 
dpedvetwavsprgagylfgskvtke............fvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledae
subfamily_PPP2C_pd Subfamily PPP2C 49-343 1.4e-42 138.8 In-house 14-282 (290) alignment 
Range on Protein: 49-343
Range on HMM: 14-282/290.0
KNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRalLARTEQDITDeqksnfsTrqfvrdKYVFLGNYIDKGPRSIECICLLFAFK
 ..|. .|| ..|  . . ..||.|. ||..||||.|||||.||||    | .   .  |       |      .|.|||.|.|.|  |.|...|| |.|
ckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdlle..lfkiggkspd.......t......nylflgdyvdrgyysvetvtllvalk

ICFPQKYILLRGPHECPSVNSseFLGV-METFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEDPLaTDLLFA
. ....  .||| ||   .      |   | .      .. | | . | ..||.|.| ..|.|.|||.||.... ..||...|  .   | || .|||..
vrykeritilrgnhesrqitq..vygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegpl.cdllws

DTLDFDLIHIPTRKPKYEFNviRNMSvmyneaavTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE-SNYGAVLKIDGNAKITIIS
|  | .   |  |   | |   ...|         .| .. .|.||.|.|  |  ||..  .....||| .  . .   | .|.|..| . | ... 
dpddrggwgisprgagytfg..kdis........ekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflq
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 59-352 4.4e-41 134.0 In-house 27-297 (307) alignment 
Range on Protein: 59-352
Range on HMM: 27-297/307.0
SVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALLARTEQDITdeqksnfstrqfVrdkYVFLGNYIDKGPRSIECICLLFAFKICFPQKYILL
 |       |  |. |...  |. |.||.||.| ||   ..       |            |   ||| |.|.|.|  |.||| |||..|||.|.. .||
nviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppet............v...yvftgdyvdrgllslecilllftykicypenivll

RGPHECPSVNSS-EFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRPLKDATEdPLATDLLFADTlDFDLihi
|| ||   ||    |     |  |.  ..|   |. .|  .|..|..  ||||.|||.|| ||  ...|.  .|...     .  |.|.||  |  .   
rgnheiarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfr.givndmlwadp.dpsv...

ptrkpkYEFN-VIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQN-ESNYGAVLKIDGNAKITIISLLPQQSKAE
      .|..   |   . .    . . | .. ..||||.|  .  ||  .| ..||||| .  . |   | |.|||.|    | .....|.  . |
......fewkassrgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpesenie
subfamily_PPP5C_pd Subfamily PPP5C 32-338 1.8e-40 131.9 In-house 18-299 (322) alignment 
Range on Protein: 32-338
Range on HMM: 18-299/322.0
FEFLKKMIQpgrVMKrSKNNLSSNEVWSVCRAVIDEFKKEQNLMEVSAP----VTVIGDVHGNFHDLYRALlarteqditdEQKSNFSTrqfvRDKYVFL
 ||.|....    .| ....|    . ..   . . .||.  |.|.. .    .|| ||.||.|.||.  .          | .   |.    .. |.| 
kefvkelle...lfk.kqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnif..........elnGlpse....enpylfn

GNYIDKGPRSIECICLLFAFKICFPQKYILLRGPHECPSVNssEFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISP-RLTSWEDIR
|...|.|  |.|.| .|..||. .|... | || ||  ..|  .. |  .     . .|. . |.| |.|.||| |. .|.| ||||.      . .|.|
GdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmn..klyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlr

KIKRPLKDATEDPLaTDLLFADtldfdlihiPTRKPKyEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQ-NES
||.|  .. .|. |  .||..|         | ...    .  | ..| .     ..|... ||.||||||     ||..  . .|||.| .  .  . .
kidrnaqppeegll.vellwsd.........pqeanG.rspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmg

NYGAVLKIDGNAK
| ||.... |. .
nkgafitlrgddl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 122-347 2.2e-40 131.8 In-house 120-334 (339) alignment 
Range on Protein: 122-347
Range on HMM: 120-334/339.0
DKYVFLGNYIDKGPRSIECICLLFAFKICFPQKYILLRGPHECPSVNSSefLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTS
 .|.|||.|.|.|| |.| . || |.|...|..  |||| ||  |||.|   |.       .  .... |.. |  .|..||. . |.|.||||| .|||
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvnts..ygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehlts

WEDIRKIKRPLKdATEDPLATDLLFADTldfDlihiPTRKPkYEfNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGF
....  .||||.   .  . ||| .||    |    || |  |.    |  |...   |.  | .|..|...|| |  |  || ||  .||.||| .  .
fnqfsvfkrple.ipdvgvltdltwadp...d....ptekg.yk.psargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapny

Q-NESNYGAVLKIDGNAKITIISLLPQ
  .. |  ||. || . ||.|  . |.
cgqndntaavfsidkklkisinvfrpe
subfamily_PPP7C_pd Subfamily PPP7C 47-347 5.5e-38 123.7 In-house 28-335 (383) alignment 
Range on Protein: 47-347
Range on HMM: 28-335/383.0
RSKNNLSSNEVWSVCRAVIDEFKKEQNLMEVS----APVTVIGDVHGNFHDLYRALlarteqditdeQKSNFSTrqfVRDKYVFLGNYIDKGPRSIECIC
. |. | .. |  . |   ...|. .|. .||      ||| ||.||.. ||   |            |  . .    .. ||| |...|.| .|.| ..
kekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllil...........yknGlps...eenpyvfnGdfvdrGkesveill

LLFAFKICFPQKYILLRGPHECPSVNSS-EFLGVMETFSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRlTSWEDIRKIKRP-LKDATEDPL
.|.|. . .|..  | || ||   .|    |.  .|.  ..| ||| . ... |.|.|||... .||| |||||| . |. | . ||.|  |.   . ||
illalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdk.tdlelldkiersklvsvlrppl

ATDL----------LFADTLD----FDLI-HIPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTG-FQNE
 ..           .  |. .    .|..   |  |     |..|   . .     ... .|.||||.||||   | || |  .|...||| ..  ... 
kegeeaekekeessvkvdkeewrqvldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeG

SNYGAVLKIDGNAKITIISLLPQ
|| || .|.  . .  |.    .
snrGayvklgkdltprivqyqas
subfamily_PPG1_pd Subfamily PPG1 56-324 1.1e-35 116.4 In-house 18-272 (300) alignment 
Range on Protein: 56-324
Range on HMM: 18-272/300.0
EVWSVCRAVIDEFKKEQNLMEVSAPVTVIGDVHGNFHDLYRALlaRTEQDITDeqksnfsTrqfvrdKYVFLGNYIDKGPRSIECICLLFAFKICFPQKY
 | ...  . . . || |..|. .||||.|||||.|.|.   .  .   .. |       |      .|.|||.|.|.|  |.| | || ..|. .| . 
tvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleif..kiggqvpd.......t......nylflgdyvdrglysvetisllivlklrypsri

ILLRGPHECPSVNSS-EFLG-VMETFSPNhfKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIRKIKRpLKDATEDPLATDLLFADTL--D
 |||| ||   .  .  | . ... .. |   .. | . | | .. |||.. ..| |||||.||   | ..|. . | ...  ..   .|||..|    .
tllrgnhesrqitqvygfyteclrkyggn..srvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldr.frevpnegaladllwsdpeenn

FDLIHIPTRKPKYEFNVIRNMSVMYNEAAVTQFCEKFNLKLIIRSHMKVPFGYRFFSEKRLITIFNSTGFQNE
   .. | |. ..  .  |     | .  | .| .. ... |||.|  .  ||. . ...| |.. .  . . 
nptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyr
Metallophos Calcineurin-like phosphoesterase 80-298 4.4e-32 105.0 Pfam-A 2-197 (200) alignment 
Range on Protein: 80-298
Range on HMM: 2-197/200.0
PVTVIGDVHGNFHDLYrallarteqdItDEQKSNFSTRQFVRDKYVFLGNYIDKGPRSIECICLL--FAFKICFPQKYILLRGPHECPSVNSSEFLGVME
...||||.||...||.          . .. . .    .   | ..||| ..| |..|.|...||  .. |. .| ...|||| ||....||        
rilvigDlHgglddle..........d.lllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleq

T--------------------------------FSPNHFKKIHKKFNEAFSWMPLAAVVGQKILCVHGGISPRLTSWEDIrkikrplkdatedplatdll
                                 . |......  ...| | ..||.| |..|||..||..|... |..||                    
lkdlrglangeeeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi....................

fadtldfdlihiptrkpkyefnvirnMSVMYNEAAVTQFCEKFNLKLIIRSHM
                           |. ... |.  ..|| ...|..|.| 
..........................gselfgpdalekllekygvdlvlrGHt
subfamily_YNL217W_pd Subfamily YNL217W 81-218 8.8e-06 18.4 In-house 12-139 (235) alignment 
Range on Protein: 81-218
Range on HMM: 12-139/235.0
VTVIGDVHGNFHDLYRaLLartEQDITDEQkSNFStrqfvrdkYVFLGNYIDKGPRSIECICLLfafkicFPQKYILLRGPHECPSVNSSEFLGVMETFS
. |.|||||.. .| . ||   .. | . .  |           |..|. |.|||.|.| . ..        ..   ..| ||   . . ...   . . 
llvvGdvhgaYDelie.Ll...ddkiggkd.envl........vvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgae

PN----HFKKI-HKKFNEAFSW---MPLA-AVVGQKILCVHGGISPR
|     .|. . .|  ..  ..   .. .  . ....| ||.|..| 
plefsskfsflesklskadmeyarelgfsldipsdellvvhaGlvpg