Gene ZK354.9 in Caenorhabditis elegans

Synonym: CELE_ZK354.9, CELE_ZK354.9

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP235_AA protein Get Run
CeleP235_AA_22-291 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 23-293 4.7e-200 655.8 In-house 14-284 (284) alignment 
Range on Protein: 23-293
Range on HMM: 14-284/284.0
RTCNIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDEC
....||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||
hafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeec

QRRYNKPSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLAIDILWSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDR
||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
qrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsdalrklldr

LQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRKKIARRRMMP
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkkiarrrmmp
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 24-286 6e-152 497.8 In-house 36-297 (298) alignment 
Range on Protein: 24-286
Range on HMM: 36-297/298.0
TCNIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQ
. .||.||..|.| ..||..|||||||.|||||||||.|||..|||||||||||||...||.|.||.|||| .||.||.|||||||..||..||||.||.
akkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnheceainrvyGfyeeck

RRYNKPSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPnTLAIDILWSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDRL
|||.. ..| .|..||. .|||||.|.||||||||.||.|....|||..|||||..|. .||||.||.||.|..|||..||||||.|||.|....||..|
rrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskee.slaidllwadpenavkgwaensrGvsvvfGedvvkdllekl

QIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRKKI
.|||||||||||||||||||...||||||||.|||||||.||||.|...||.||.||.|.||.
didlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekke
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 26-287 3e-124 407.1 In-house 38-298 (299) alignment 
Range on Protein: 26-287
Range on HMM: 38-298/299.0
NIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQRR
..| .|. |.| ..|| .|||||||.|||||.|||.|||  .|.||||||||||.  ||.| ||...|. .|..||||||||||  ||..||||.||..|
svfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecnkr

YNKPSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPnTLAIDILWSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDRLQI
|.   ... |.  |. |||| |.| ||||||||.|  ||.. ||| . || | |.| .| ||.||.|| .. |.| .| |||||||| | ... ..||.|
ykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnp.slgidllwadpdqsvkdwlanvrgvsyvfgqdvvadvisrldi

DLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRKKIA
||| ||||||||||||||...|||||||| |||||||.||.| |..||||.||||.| .| .
dlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpksl
subfamily_PPP1C_pd Subfamily PPP1C 24-285 3.6e-120 393.4 In-house 22-281 (282) alignment 
Range on Protein: 24-285
Range on HMM: 22-281/282.0
TCNIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQ
. .|. .||.|.| . |..|.||||||..||||||...|.| ..|||||||||||||. ||||.||.|||. .|...|.||||||.. ||.||||||||.
areillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasinriyGfydeck

RRYNKPsVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPnTLAIDILWSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDRL
|||..  .. .|  ||. .||.||| ..|||.|||.|. |....|.| |.|| . ||  .|..|.||||| . ..||. |.||||..||.|...|.| . 
rrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpek.gllcdllWsdpdkevlgwsendrGvsftfgkdvvekflqkn

QIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRKK
..||.|||||||.|||||||.|.|||.|||| |||.||||.||. |...|..|| .|.|.||
dldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpakk
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 25-283 6.8e-116 379.3 In-house 19-275 (280) alignment 
Range on Protein: 25-283
Range on HMM: 19-275/280.0
CNIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQR
 .|.  |  ..| ..|...|||.|||..||||||.. .||   ||||||||||||.. || ||||.|||| .||.|..||||||.  ||. |||.||..|
kkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygfkdevkr

RYNKpSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEpNTLAIDILWSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDRLQ
||.. ..|  |. ..  .||.|||. ||||||||.|. |. ...|. ..||||... ..|| |.||.|| | . ||  ||||||..||.. ...| ..|.
rysl.alynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsed.eclamdllwadpenkvtgwaensrgvsvifganvvkdltekld

IDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPR
|||..| ||||||||||||...|||.|||| |.|.|||.|||. |...|. || ||.| 
idliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
PP2Ac_SM00156 23-283 8e-116 378.8 In-house 12-270 (271) alignment 
Range on Protein: 23-283
Range on HMM: 12-270/271.0
RTCNIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDEC
....|......|.|...|. ..||||||..|||||....|.|.. .|.|||||||||....|.||||||.|...|.....||||||.| .||||||..|.
evkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvnkiygfeeev

QRRYnKPSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRpFDNPEPNTLAIDILWSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDR
.|.| . ..|  || .|| .||.|||...|||||||.|..|......| .|| ..... ..|.||.|||||.. .||..|..||.|.|||.||....|..
krky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkr.vkekpeegllidllwsdpeqkekgfqpskrglsvvFgedavkeflkk

LQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPR
....|..|||.||..||||||...|||||||| ||..|.|.|||. |.||| .|...|.. 
nnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 25-283 2.4e-104 341.7 In-house 36-295 (297) alignment 
Range on Protein: 25-283
Range on HMM: 36-295/297.0
CNIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQR
 ..|..|  ..| |.||..|||||||| |||||| . |.|  |||||||||||||.  .|||.||.|||| ||  .|.||||||| ..||.||||.|||.
ldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkvygfyeecqk

RYNKPSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQ---NVSQLRAIKRPFDNPEpnTLAIDILWSDPTNFQKGWNPNSRGVSYVFGSDALRKLLD
||.   .|..|. ||  .||| |. ..|||||||.| .|     .  || |.|. .  |  .|  |.||.||     |.  | ||    || ||. ||  
ryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegke..rlvadllwadpisglsgfmenqrgagcgfgrdavlklcs

RLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPR
 ...|||.|||||||||||||| |.|||||||| |||||||.||.| ....| ||| .||| 
efkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 23-282 4.2e-101 331.1 In-house 19-282 (284) alignment 
Range on Protein: 23-282
Range on HMM: 19-282/284.0
RTCNIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFP------HRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIY
|. ..| |... .| ..|..|.||||||| ||| |.| ||.|      .  .||||||||||| . .| |.||||||...|.. |.||||||   .|. |
rarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqy

GFYDECQRRYNKpSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNtLAIDILWSDPTNFQKGWNPNSRGVSYVFGSDAL
||| ||..|| . ..| .|.  |  |||.|.|...|.|||||.|. | .. || ...||.| |.   .  |. |.|| .  .|..   ||   |||..|.
gfyleckkryse.alyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdig.viadltwadpeaevegykesprgagkvfgakav

RKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRP
...|.. ..||||||||||.|||||||.|.||||||||.||||.||.|||. |...||.||.||.|
keflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_PPZ_pd Subfamily PPZ 4-285 6.4e-100 327.5 In-house 19-296 (300) alignment 
Range on Protein: 4-285
Range on HMM: 19-296/300.0
RRRVVCLRARARPQSLRRRRtcNIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFML
| . |||.     |   . |  ..|  || |.| . ...| ||.|||..|||||| | |||  ||||||||||||||..|||||||..||. .|. ||.|
rtknvclknseilqicikar..elflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffll

RGNHECSLINKIYGFYDECQRRYNKpSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPnTLAIDILWSDPTNFQKGWNPN
||||||. . ..|||||||.|| |   .. .|   |  .||.|.|  .|.|.|||.| .|... ..| . || | |.   |  |.||||||. .. |. |
rgnhecanvtrvygfydeckrrcni.kiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdf.glindllwsdptdssnewedn

SRGVSYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRKK
 |||||..   |. |.|... .|||.||| ||.|||||| .| |||.|||| |||.|||  ||| |.. |.||| .| |   
ergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldplds
0045823 Metallo-dependent phosphatases 23-291 2.6e-99 326.0 In-house 54-332 (473) alignment 
Range on Protein: 23-291
Range on HMM: 54-332/473.0
RTCNIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDEC
....|..|.|.|.| . .| ..||||||. |||||..|.|||.  ...||||.|||| . ||...||.|.|. .|...|.||||||. |.| .|||.||.
eakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdet

QRRYNKPsVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEpNTLAIDILWSDPtNFQKG--------WNPNSRGVSYVFGSD
 ..|. . .|  |  ... .||.|..|..||..|||.|  |....|.|.|.||.. |. . |. |.|||||   ..|        . .. ||..|.|| |
lekyged.lyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipd.dgllldllwsdP.weddgdgllrlrffgnsprgagylFgpd

ALRKLLDRLQIDLVVRAHQVVQDGYEFFANRR------LVTIFSAPFYCGQFDNAAAVMYVNKNLvCSFVVLRPRKKIARRRM
|....|.. ..||.||.|..|..|||.. ...      ..|.|||| |||...| |||......| .||....| .   .. .
aveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphplilpl
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 26-285 6.7e-99 323.4 In-house 24-284 (287) alignment 
Range on Protein: 26-285
Range on HMM: 24-284/287.0
NIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQRR
.|..  | |.| ..||.|.||||||. ||||.|.. | . . .||||||||||| . || .||||..|. .|..  .||||||.  |||.|||..| .|.
eileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinklyGfkeelkrk

YNkPSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEP-NTLAIDILWSDPTNFQKGWNPN-SRGVSYVFGSDALRKLLDRL
..  ..|  |. |||..|| | |..||||||||.|. |. . .|.|.|.|  . .  . | .|.||.||.. .|. ..|  |..| |||   . .|| .|
rq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfGkkevddllkkl

QIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRKK
.|||.||||.|...||.|....||||.||||.|.|.  | .||. |.| |  |||||.| . 
didlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedf
PPP_3 23-280 2.4e-96 314.9 In-house 13-269 (271) alignment 
Range on Protein: 23-280
Range on HMM: 13-269/271.0
RTCNIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDEC
.. .|..|...|.| ..|...|||||||. |||.||.. |.... .||||||||||||. ||..|||.|.|. .|.....||||||.. |||.|||..|.
klkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqinkvYgFkkev

QRRYNKPSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEpNTLAIDILWSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDR
...... .||  .. ||. .||.||. ...|..|||.|. .....|.. ..|. . || ... .| |.|.... ..|.....||....||.|. ...|..
lkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpe.egklldlllssdpekeeglenskrGagllFgpdvteeflek

LQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVL
 ...|..|||.....|||.......||.|||| ||....||.|.. ....| ..|..|
nkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
0049330 Metallo-dependent phosphatases 23-288 3.7e-96 314.8 In-house 41-304 (309) alignment 
Range on Protein: 23-288
Range on HMM: 41-304/309.0
RTCNIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDEC
....|. ..|.|.| . .| ..||||||. |||||..|.|||   ...||||.|||| . ||..|||.|.|. .|...|.||||||. |.| .|||.||.
kakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvfllrGNHElrllnglygfgdet

QRRYNkPSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPnTLAIDILWSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDR
.|.|. ....  |  ... .||.|..|..|||.|||.|  |....|.|...||.. |.   |  |.|||||... .|. || ||...||| .|....| .
lrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipld.gllcdllwsdplpiregfapnprglgvvfghtaverflkk

LQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRKKIAR
...||..|.|..|..||..|....|.|.|||| |||...|..||......||.||....| . . .
ngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpllll
PPP_1 24-268 4.8e-91 297.7 In-house 13-263 (264) alignment 
Range on Protein: 24-268
Range on HMM: 13-263/264.0
TCNIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQ
. ...||...|.| ...| .|||||||| |||.|| . |.... |||||||||||||. .|..|||.|.|. .|...|.||||||.. ..|.|||..|..
lkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkvygFkkEvl

RRYNKPSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLAI------DILWSDPTNFQKGWNPNSRGVSYVFGSDALR
... . ..|  .. ||  .||.||. ..||..|||.|..|. . | | ..|  . ||  .|        |||.||... ..... . ||..|.||.|. .
kkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGagylfgkdvte

KLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMY
|.|.. ...|..|||.|...||||...|..||||||. |. ...|..|.. 
kflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 67-283 5.3e-91 298.1 In-house 101-315 (317) alignment 
Range on Protein: 67-283
Range on HMM: 101-315/317.0
ANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQRRYNKpSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNV
 .||||||||||| . .| ..||||.|. .|.. |.||||||   .|. |||| |...||.. ..| .|. .|  .||.|.|...|||||||.|. | ..
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysa.alyeafqlafnvlplcavvnkkilcmhGGiseelldl

SQLRAIKRPFDNPEPNTLAiDILWSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAV
.|| ..|||.| |.   || |. |.|| .  ||... .|| . |||..|....|..|..||||||||||.|||||||.|.||||||||.||||.||.|||
kqldklkrpldipdvGvla.dltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav

MYVNKNLVCSFVVLRPR
. |.|.|..|. |||| 
lsvdkklkisinvlrpe
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 26-283 4.9e-89 291.3 In-house 22-277 (281) alignment 
Range on Protein: 26-283
Range on HMM: 22-277/281.0
NIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQRR
 || ..  |.|...|| . ||.|.|| || |||.  | . .  ..|||||||||...||...|||..|. .... ..|||||| . .||||||| ||. .
aifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygfyvecvtk

YNKpSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEpNTLAIDILWSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDRLQI
| .  ... |.  |  .|..||. .|.||||||.|  | .  .|| . .| .|..   | ||.||.||.|  ..|   |||.|..|| . . .   ||..
yGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnld.rGlviDllwadpdnkveewkassrGssftfGknvvddvckrlev

DLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPR
.|..||||||||||| .. |.|.|.||.| || .. |||||. |...|  |.| | | 
eliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpa
0053225 Metallo-dependent phosphatases 23-283 1.6e-88 289.9 In-house 33-291 (293) alignment 
Range on Protein: 23-283
Range on HMM: 33-291/293.0
RTCNIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDEC
 ...|. |.|.|.| . .| ..|||||.. |||.|..| |||.  ...||||.|||| . ||...||.|.|. .|.....||||||. |.| .|||.||.
eakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNHElmllnglygfgdet

QRRYNKPSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNtLAIDILWSDPTnFQKGWNPNSRGVSYVFGSDALRKLLDR
 |.|   ...  .  ... .||.||.|..||..|||.|  | ...|.| |.||.. |. . |  |.|||||. . .|| |. ||...||| .|....|..
lrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplripleg.llldllwsdpd.lwsgwlpsyrglgvvfghtavlrflkk

LQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPR
 ..||..|.||||.|||... ...|||.|||| |.|...|..||......||..|....|.
ngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 34-289 1.3e-85 280.3 In-house 2-262 (263) alignment 
Range on Protein: 34-289
Range on HMM: 2-262/263.0
LIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQRRYNKP----
|.| ..||||||| |||. ||||.|.  |   ...||||||||||| | || |.|||. |. .| ....||||||   ||| |||. | ..|...     
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

SVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLAIDILWSDPTNFQKGWNPNS-RGVSYVFGSDALRKLLDRLQIDLV
|||  |. ||| ||| |.| .||||||||.|  |... ..|||  |..  .   || |.||.|| .  ||..||  | .| |||   .  |  ||.|||.
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

VRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRKKIARR
|||||||. || |||.|||.|.|||  |  .. | |||. ||| |  ||| |.|     ||
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpedfevrr
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 25-282 1e-83 274.1 In-house 19-274 (280) alignment 
Range on Protein: 25-282
Range on HMM: 19-274/280.0
CNIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQR
  || ..  |.||..||.. |||| |. |. ||||  |     . .||||||||| . .| ..|||. |. . .. ..||||||   .||||||| ||| 
eaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqy

RYNKpSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDnPEPNTLAIDILWSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDRLQ
.|    ..  |. .|  ||...|. .|.||||||.|  | |.  .| | || . |    | ||.|||||||  .||  . ||.||.||   . .    |.
kygv.glwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpce.pldrgllidllwsdptnkgegwfhsirgisymfgkgvveqacksle

IDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRP
|||..|||||||||||..| |||.|.|| | || || |||||. .| ||  ||  | |
idliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlip
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 26-284 4.2e-83 271.7 In-house 30-290 (290) alignment 
Range on Protein: 26-284
Range on HMM: 30-290/290.0
NIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQRR
.|..  | |.| ..|| | ||||||. .||| ||. |.| . ..|||||||||| . ||  |||| ||. ....  .||||||.  .|..|||..|  |.
eileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrlygfkeelark

YNKpSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEP-NTLAIDILWSDPTN-FQKGWNP-NSRGVSYVFGSDALRKLLDR
 .   ..  .. ||....| | ||..|||||||.|. ..    |.|.|.|  . .  . | .|.||.|||.  ..  .    |..| ||| ..| .|| .
rgs.rlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvvfgkkglddllkk

LQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRK
| ..|.||||.| ..|..|  ...|||.||||.|.|.  |  |.. | . |  |.|||.|||
lalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkprk
subfamily_PPP4C_pd Subfamily PPP4C 26-280 5.3e-81 265.0 In-house 30-282 (288) alignment 
Range on Protein: 26-280
Range on HMM: 30-282/288.0
NIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQRR
.|. ..  . . .||. .|||||||| |||.||. .|  .  |||||||.||||.. .||.||| |.|| .|..  ..|||||.  | ..||||||| |.
eilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitqvygfydeclrk

YNKPSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLaIDILWSDPTNFQkGWNPNSRGVSYVFGSDALRKLLDRLQI
| . .|.     ||  ..|.|.. ..|.|.|||.|  .... ..|.| |  . |.  .| .|.||||| . . ||.   ||  |.||||.  .. .. .|
ygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegpl.cdllwsdpedae.gwavsprgagylfgsdvveqfneandi

DLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVL
.|..||||.|..|| .  |....|..||| || .  | ||.. ....|   | ..
elicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkif
subfamily_PPP2C_pd Subfamily PPP2C 25-282 8.5e-79 257.7 In-house 30-285 (290) alignment 
Range on Protein: 25-282
Range on HMM: 30-285/290.0
CNIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQR
 .|..|.  . | ..|. .|||.|||| ||| ||   |    .|||||||||||| . .||. || | || ...   .||||||   | ..||||||| |
keilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqitqvygfydeclr

RYNKPSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLAiDILWSDPTNfQKGWNPNSRGVSYVFGSDALRKLLDRLQ
.| ...|.  |  .|  .|||||| ..|.|.|||.| ... . ..||..|  . |.  .|. |.||||| . ..||.   ||  | || |  .|. .. .
kygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplc.dllwsdpdd.rggwgisprgagytfgkdisekfnktng

IDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRP
. |..||||.| .||..  .|..||||||| || .  | ||.. ....|  ||.   |
ltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdp
subfamily_PPP5C_pd Subfamily PPP5C 26-273 1.6e-75 247.1 In-house 48-299 (322) alignment 
Range on Protein: 26-273
Range on HMM: 48-299/322.0
NIFNKQPMLIEANS----PINICGDIHGQFSDLLRLFDKNGFPHRA-NYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYD
....|.| |.| .      . .|||||||| ||| .|..|| | .   ||| ||.|||| . .|.||.|...|...|||||. ||||| . .||.||| .
ellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfeg

ECQRRYNKpSVYVSFEGVFSDMPLTALVGQRILCMHGGVS-KMLQNVSQLRAIKRPFDNPEPNTLaIDILWSDPTNfQKGWNPNSRGVSYVFGSDALRKL
|.. .|..  |.  |  ||. .||. .. ...| .|||.  .   ....|| |.|  ..|| ..| ...||||| . ..| .| .|||.  || |  .|.
evkakyte.kvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegll.vellwsdpqe.anGrspskrGvgvqfGpdvtkkf

LDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYV-NKNL
|.  ...|..|.|.| ..|||.  . .|.|.|||| || | .| .|.. . ...|
lkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddl
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 26-284 1.5e-74 243.9 In-house 20-301 (302) alignment 
Range on Protein: 26-284
Range on HMM: 20-301/302.0
NIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKN----------GFPH-RANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINK
. ..|.  |.|  .|. | ||||||| ||.|.. ..           . . .  ..|||||||||.. .| | |.||.||..|... .||||||.  || 
ellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainf

IYGFYDECQRRYNKPS---VYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLAIDILWSDPTNFQKGW--------NP-
 ||| .| . |. |     ..  |. ||| |||.||||..|||.|||.|. |. . ... ||||. .  ...|| |.|..||...|.          .  
aygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaavsekPkyakn

NSRGVSYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRK
. ||.|.||   |.|..  ||...|.|||||..  |. |||...|.|||||| |  . ||  ||. |. |   |  |||..|
ivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrnkk
subfamily_PPP3C_pd Subfamily PPP3C 24-273 1.9e-74 244.1 In-house 53-313 (452) alignment 
Range on Protein: 24-273
Range on HMM: 53-313/452.0
TCNIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQ
......|.. |.| ..|| ..||||||| |||.||. .| |. ..||||||||||| . .|..| |.| |. .|...|.|||||||  . . . | .||.
aakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeck

RRYNKpSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRpFDNPEPNTLAIDILWSDPT-NFQK-----GWNPNS-RGVSYVFGSDAL
 .|.. .|| ..   |  .||.||. |. ||.|||.|  .... ... ..| | .|.   .  |.|||||. ....      . ||| || ||...  | 
ikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldr.fkeppasGplcdllWsdPledygeekteekfvpnsvrGcsyfysykav

RKLLDRLQIDLVVRAHQVVQDGYEFFAN------RRLVTIFSAPFYCGQFDNAAAVMYVNKNL
 ..|.. ..  ..|||.. ..||. . .        |.|.|||| |.. ..| |||. ...| 
ceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennv
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 26-283 4.9e-74 242.2 In-house 21-301 (302) alignment 
Range on Protein: 26-283
Range on HMM: 21-301/302.0
NIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKN----------GFPH-RANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINK
. ..|.  |.|  .|. | ||||||| ||.|.. ..           . . .  ..|||||||||.. .| | |.||.||..|... .||||||.  || 
ellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainf

IYGFYDECQRRYNKPS---VYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLAIDILWSDPTNFQKGW--------NP-
 ||| .| . |. |     ..  |. ||| |||.||||..|||.|||.|. |. . ... ||||. .  ...|| |.|..||...|.          .  
aygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaavsekPkyakn

NSRGVSYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPR
. ||.|.||   |.|..  ||...|.|||||..  |. |||...|.|||||| |  . ||  ||. |. |   |  |||..
ivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrnk
subfamily_PPP6C_pd Subfamily PPP6C 25-273 5.5e-73 238.6 In-house 28-274 (290) alignment 
Range on Protein: 25-273
Range on HMM: 28-274/290.0
CNIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQR
.... ..  .   .||. .|||||||| ||. || . |    ..|.||||.|||| . |||. .|.. |. .|..  .||||||.  | ..|||||||..
ldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygfydecln

RYNKPSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLAiDILWSDPTNFQKgWNPNSRGVSYVFGSDALRKLLDRLQ
.| . ...  .  ||  ....|.. ...||.|||.|  .. . |.| |.|  . |.  ... |..|||| . .. |.  .||  |.|||   ....   .
kygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafc.dlvwsdpedvet.wavsprgagylfgskvtkefvhinn

IDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNL
..|..||||.|..|.... . .|||..||| || .  | |... .... 
lklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledae
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 68-284 2.6e-72 236.8 In-house 121-335 (339) alignment 
Range on Protein: 68-284
Range on HMM: 121-335/339.0
NYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQRRYNKpSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVS
 |||||||||||   .| ..|| | |. .|.. ..||||||   .|  |||| | . ||.   .|  |. .|  .|. |.. . |.|||||.|. |  . 
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryda.qlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QLRAIKRPFDNPEPNTLaIDILWSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVM
|.  .|||.. |.   |  |. |.||   .||..| .|| |.|||  ||| .| .|....|.| ||||.||||||  |||||||||| |||| ||.|||.
qfsvfkrpleipdvgvl.tdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavf

YVNKNLVCSFVVLRPRK
 ..|.|  |  |.||  
sidkklkisinvfrpes
PPP_2 41-234 1.5e-69 226.7 In-house 1-197 (198) alignment 
Range on Protein: 41-234
Range on HMM: 1-197/198.0
INICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQRRYNKPSVYVSFEGVFS
...|||.|||..|||.||.. ..... .||||||||||||. ||..|||.|.|. .|.....||||||.. .||.|||..|....... .||  .. ||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

DMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLaIDIL----WSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDRLQIDLVVRAHQV
 .||.||. ...|..|||.|. .....| . ..|. . || ..| .| |    .|||.. ........||....||.|. ..||.. ...|..|||.|
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegkl.ldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 41-234 3.5e-67 219.3 In-house 1-196 (197) alignment 
Range on Protein: 41-234
Range on HMM: 1-196/197.0
INICGDIHGQFSDL-LRLFDKNGFPH-RANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQRRyNKPSVYVSFEGV
. ..||||||. || |.|... |.|. . .|.||||||||||. ||..|||.|.|. .|.....||||||.. .|..|||..|.... .. ...  .. |
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLAIDI-LWSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDRLQIDLVVRAHQV
|. .||.||. ...|..|||.|. |........|.|... |  .... |. |||||.. |.|.... ||....||.|. .|.|.. ...|..|.|..
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 26-283 9.2e-67 218.4 In-house 34-292 (307) alignment 
Range on Protein: 26-283
Range on HMM: 34-292/307.0
NIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQRR
 ||  .  |.. . |  . ||.|||| ||. .|   | |  . |.| |||||||  .||.|||||.||...|..  .|||||| . .|| ||||.||   
tifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvts

YNKP--SVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEpNTLAIDILWSDPTNFQKGWNPNSRGVSYVFGSDALRKLLDRL
  |    ..  |. .| ..|..||.  .|||||||.|  |  . .||   .|  ||    .  |.||.||      |.  |||  . ||.. .  .  ||
ipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpf.rgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrl

QIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPR
 ..|..||||.. |||  .. |.|.||||||.||  . || .|. |.. |    | . | 
gveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpe
PPP_5_Dcr2 41-235 1.4e-65 214.0 In-house 1-199 (199) alignment 
Range on Protein: 41-235
Range on HMM: 1-199/199.0
INICGDIHGQFSDL-LRLFdKNG-FPH-RANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQRRYNKPSVYVSFEG
. .|||.|||. || |.|| |.| .|  . .|.||||||||||. ||..|||.|.|. .|.....||||||.. .|.||||..|....|.. ..|  .. 
vtvcGDlHGqlddlllilf.keggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsd

VFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLAIDI-LWSDPTNFQKG-WNPNSRGVSYVFGSDALRKLLDRLQIDLVVRAHQVV
||. .||.||. ...|..|||.|. ......|..|.|... || .    |. |||||.. |.| . .. ||....|| |. .|.|.. ...|..|.|...
vfdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_PPG1_pd Subfamily PPG1 30-278 3.8e-62 203.2 In-house 32-291 (300) alignment 
Range on Protein: 30-278
Range on HMM: 32-291/300.0
KQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQRRY-NK
|.  .|| .||. . ||.|||| |.| .|.  |    .|||||||||||| . .||| || . |. .|    .||||||   | ..|||| || |.|  .
kesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyteclrkyggn

PSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLRAIKRPFDNPEPNTLAiDILWSDPT---------NFQKG--WNPNSRGVSYVFGSDALR
. |.  .  .|  . |.|.. . | |.|||.|   . . |.. . |  . |.  .|| |.|||||            ..|  .    ||  | .| |   
srvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegala.dllwsdpeennnptldhpdregqhfvvsqrgagysygkdvve

KLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFV
|.|   ... ..||||....||. . . .| |..||| || .  | |... .....   | 
kflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfn
subfamily_PPPLV_pd Subfamily PPPLV 25-272 2.1e-54 177.8 In-house 10-279 (290) alignment 
Range on Protein: 25-272
Range on HMM: 10-279/290.0
CNIFNKQPMLIEANSPINICGDIHGQFSDLLrLFDKN----GF-PHRANYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFY
 .|. ..  |.| .||. . ||.||.. ||   |.|     |     |..||||||||||.. .| |  |.| ||..| ....||||||   . . . ..
vdilaaeerllelksptyvlgdlhgnyrdli.yfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieyk

DECQRRYNK--PSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQL---RAIKRPF-DNPEPNTLAIDILWSDPTN-----------FQKGWNP
 |.. .. .   .|. .|  ||  .||.| . ....|.|.|. .  .  ...   . |   . |. .   ||.||||||| .            ..|. .
gegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGfvd

NS-RGVSYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKN
|. || ..||..||| ..| | ... |.|||.| . |...  . ||.|.||.  |||. ..|| ..  .|.
ndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalilvdkkk
Metallophos Calcineurin-like phosphoesterase 40-235 8.3e-43 140.0 Pfam-A 2-199 (200) alignment 
Range on Protein: 40-235
Range on HMM: 2-199/200.0
PINICGDIHGQFSDL----LRLFDKNGFPHRANYLFLGDYVDRGKHCLETILLL--FAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQR---------
.| ..||.||.. ||    |.|..... .   ..|||||.||||.. .||. ||  ...|. .|...|.||||||.. .|. |||..|. .         
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------RYNKPSVYVSFEGVFSDMPLTALVGQRILCMHGGVSKMLQNVSQLraikrpfdnpepntlaidilwsdptnfqkgw
                         ....|..  .. .|  .|| |||...||..||..|. .... .                                
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

npnsrgVSYVFGSDALRKLLDRLQIDLVVRAHQVV
       |. ||.|||.||| . ..|||.|.|. .
......gselfgpdalekllekygvdlvlrGHtHk
subfamily_PPP7C_pd Subfamily PPP7C 38-174 3.2e-40 131.0 In-house 63-201 (383) alignment 
Range on Protein: 38-174
Range on HMM: 63-201/383.0
NSPINICGDIHGQFSDLLRLFDKNGFPHRA-NYLFLGDYVDRGKHCLETILLLFAYKVIFPNHFFMLRGNHECSLINKIYGFYDECQRRY--NKPSVYVS
   . .|||.||.. ||| .. |||.|    .|.| ||.|||||. .| .|.|.|. ...|..... ||||| ...|  |||  | . .|  ..  .   
skevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrl

FEGVFSDMPLTALVGQRILCMHGGVSKMlQNVSQLRAIKR
.| ||. .||..|. ..|| .|||.|..  ... |  |.|
ledvfawlplatlidekilivhGGisdk.tdlelldkier
subfamily_PPP7C_pd Subfamily PPP7C 186-284 1e-20 66.8 In-house 238-336 (383) alignment 
Range on Protein: 186-284
Range on HMM: 238-336/383.0
IDILWSDPTNfQKGWNPN-SRGVSYVFGSDALRKLLDRLQIDLVVRAHQVVQDGYEFFANRRLVTIFSAPFYCGQFDNAAAVMYVNKNLVCSFVVLRPRK
.||||||| . ..| .||  ||    ||.|  .|||.. ...|..|.|.  ..||||  .....|||||  |  .  |  | . ..|.|   .|     |
ldilwsdpka.keGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqask
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 23-66 1.5e-12 40.4 In-house 20-63 (317) alignment 
Range on Protein: 23-66
Range on HMM: 20-63/317.0
RTCNIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPHR
|. ..| |.|. .| ..|. |.||||||| ||| |.| ||.|. 
rarelfwkeplkleleapvtivGdihGqfedllalldlnGwpls
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 23-65 1.2e-08 27.5 In-house 22-64 (339) alignment 
Range on Protein: 23-65
Range on HMM: 22-64/339.0
RTCNIFNKQPMLIEANSPINICGDIHGQFSDLLRLFDKNGFPH
|. ..   .|.... ..|| . ||||||| ||| ..| ||.| 
rareliwsepiflkleapicvmgdihgqfddllamldmngwpl
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 43-232 1.7e-06 20.2 Pfam-A 5-117 (156) alignment 
Range on Protein: 43-232
Range on HMM: 5-117/156.0
ICGDIHGQFSDLLRLFDKNgfPHRANYLFLGDYVDRgkhcLETILLLFAYkvifPnhFFMLRGNHEcslinkiygfY----DECQRRYnkpsvyvsfegv
| .|.||....| .. ..      . .|..||.|..     |.. || ..    |  . ..||||.          .    .| ....            
iiSDlHgnldaleavledi..kevdlilhaGDlvep....eevvelledi....p..vlavrGnhD..........eaelpkelavel............

FSDMPLTALVGQRILCMHGGVSKmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsYVFGSDALRKLLDRLQIDLVVRAH
...   . . |.|.| .||   .                                                 .. ..|..||.  . |||. .|
llaaaaleiegdrvllvhgtpls...............................................vqsseeelaellkeagadlvflGH