Synonym: CELE_ZK484.6, ZK484.6
Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_STS_pd | Subfamily STS | 3-126 | 2e-40 | 130.7 | In-house | 1-150 (245) | alignment | ||
Range on Protein: 3-126
Range on HMM: 1-150/245.0
RTIWLVRHGQRVDNVDKKW------------------------KANNDAKWDDPeLTLRGKQQAHEVGKHF--ANMNIEAIVVSPFTRCIETAAQIVAMM
|||..||||.|||.| .|| ....| |.|.| || ||..||...|... |...||.|..||..|||.|||.|. ..
rtiyivRhgeRvdevfgkWlksfdegkyerkdlnlpkelprrpdglkdyksDpP.lterGviqAkllgraLleagikiehifcSPslrciqTaaailkgl
ENKAKICVEPGLMEPLYLCKNP-PTIPSMDKIKEYSTQVDESYKPVFEKLP
..|.||.|||||.|.|.|...| |...|....|.. .|.||.||||... .
gkkikikvepgllewlkldrkpipellspeelkkffpqidedYkpvlslse
|
|||||||||
0051064 | Phosphoglycerate mutase-like | 1-96 | 1.4e-25 | 83.1 | In-house | 2-95 (241) | alignment | ||
Range on Protein: 1-96
Range on HMM: 2-95/241.0
MSRTIWLVRHGQRVDNVDKKWKAnndakWDDPELTLRGKQQAHEVGKHFAN--MNIEAIVVSPFTRCIETAAQIVAMMENK-AKICVEPGLMEPLYLCK
| ....|||||....|..... | |..|| .|..||...|...|. ....|...||..|.|.||. | . . .. .. |.|.|.| . .
mmkrlyLvRHGesewnaegrlqg.....wtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgal
|
|||||||||
0043909 | Phosphoglycerate mutase-like | 1-91 | 5.5e-25 | 80.7 | In-house | 1-89 (249) | alignment | ||
Range on Protein: 1-91
Range on HMM: 1-89/249.0
MSRTIWLVRHGQRVDNVDKKWKAnndakWDDPELTLRGKQQAHEVGKHFA--NMNIEAIVVSPFTRCIETAAQIVAMMENK-AKICVEPGLMEP
|.....|||||. ..|..... | |..|| .|..||...|.... .....|...||..|.|.||. | . ... .. |.|.|.|
mmkrlyLvRHGetewnaegrfqg.....wlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrEr
|
|||||||||
0048955 | Phosphoglycerate mutase-like | 4-95 | 8.4e-25 | 80.5 | In-house | 2-91 (240) | alignment | ||
Range on Protein: 4-95
Range on HMM: 2-91/240.0
TIWLVRHGQRVDNVDKKWKAnndakWDDPELTLRGKQQAHEVGKHFAN--MNIEAIVVSPFTRCIETAAQIVAMMENK-AKICVEPGLMEPLYLC
...|||||....|..... | |..|| .|..||...|...|. ........||..|.|.||. | . . .. ...|.|.|.| . .
rlyLvRHGesewnaegrlqg.....wtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfga
|
|||||||||
0036777 | Phosphoglycerate mutase-like | 1-101 | 1.2e-24 | 79.8 | In-house | 1-122 (247) | alignment | ||
Range on Protein: 1-101
Range on HMM: 1-122/247.0
MSRTIWLVRHGQRVDNVDKKWKAnndakWDDPELTLRGKQQAHEVGKHFAN--MNIEAIVVSPFTRCIETAAQIVAMMENK-AKICVEPGLMEP------
|.....|||||. ..|..... | |..|| .|..||...|..... ....|...||..|.|.||. | . ... .. |.|.|.|
mmkrlyLvRHGetewnaegrfqg.....wlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGale
-----------------LYLCKNPPTI
.. .. ....
gltkaeiaekypeelvawwrdpydyrp
|
|||||||||
0036887 | Phosphoglycerate mutase-like | 3-96 | 8.4e-24 | 76.7 | In-house | 2-88 (202) | alignment | ||
Range on Protein: 3-96
Range on HMM: 2-88/202.0
RTIWLVRHGQRVDNVDKKWKAnndakWDDPELTLRGKQQAHEVGKHFANMNIEAIVVSPFTRCIETAAQIVAMMEnkAKICVEPGLMEPLYLCK
....|||||....||.... . |..|| .|..||...|...|.... |...||..|.|.||. |.. .. ...|.|.|.| . .
trlyLvRHGetewnvegrlqg.....dldvpLtelGreqaralgerlaglpfdavysSpllRaiqTaeiiaealg..lpvivdprlrEidfgal
|
|||||||||
0035570 | Phosphoglycerate mutase-like | 4-93 | 4.7e-23 | 74.3 | In-house | 1-79 (219) | alignment | ||
Range on Protein: 4-93
Range on HMM: 1-79/219.0
TIWLVRHGQRVDNVDKKWKAnndakwdDPELTLRGKQQAHEVGKHFAN--MNIEAIVVSPFTRCIETAAQIvammenKAKICVEPGLMEPLY
...|||||....|..... |..|| ||..||...|...|. ... |...||..|.|.||. | . .....|.|.| .
rlyLvRHGetewnlegrlqg.......dvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii......glpveidprLrEidf
|
|||||||||
His_Phos_1 | Histidine phosphatase superfamily (branch 1) | 4-106 | 4.8e-23 | 74.8 | Pfam-A | 1-101 (158) | alignment | ||
Range on Protein: 4-106
Range on HMM: 1-101/158.0
TIWLVRHGQRVDNVDKKWKANNDakwddPELTLRGKQQAHEVGKHFA--NMNIEAIVVSPFTRCIETAAQiVAMmENKAKICVEPGLMEPLY-LC--KNP
...|||||... | ..... ..| ..|| .|..||.|.||... . .|.|...||..|.|.||.. .. | . .|. ||.| | . . ..
rlylvRHGesewnkegrlqgwsd.....vpLtekGreqarelgkkLkradlpidavytSplkRaiqTaei.lle.eldipiikeprLrerdfgeweglpk
PTIPSMDK
. .... .
eevkeefp
|
|||||||||
His_Phos_1 | Histidine phosphatase superfamily (branch 1) | 4-106 | 4.8e-23 | 74.8 | In-house | 1-101 (158) | alignment | ||
Range on Protein: 4-106
Range on HMM: 1-101/158.0
TIWLVRHGQRVDNVDKKWKANNDakwddPELTLRGKQQAHEVGKHFA--NMNIEAIVVSPFTRCIETAAQiVAMmENKAKICVEPGLMEPLY-LC--KNP
...|||||... | ..... ..| ..|| .|..||.|.||... . .|.|...||..|.|.||.. .. | . .|. ||.| | . . ..
rlylvRHGesewnkegrlqgwsd.....vpLtekGreqarelgkkLkradlpidavytSplkRaiqTaei.lle.eldipiikeprLrerdfgeweglpk
PTIPSMDK
. .... .
eevkeefp
|
|||||||||
0039931 | Phosphoglycerate mutase-like | 4-91 | 1.1e-22 | 73.0 | In-house | 1-77 (219) | alignment | ||
Range on Protein: 4-91
Range on HMM: 1-77/219.0
TIWLVRHGQRVDNVDKKWKAnndakwdDPELTLRGKQQAHEVGKHFAN--MNIEAIVVSPFTRCIETAAQIvammenKAKICVEPGLMEP
...|||||. ..||.... |..|| ||..||...|..... ... |...||..|.|.||. | . .....|.|.|
rlyLvRHGetewnvegrlqg.......dspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii......glpveidprLrEi
|
|||||||||
0037864 | Phosphoglycerate mutase-like | 1-92 | 1.5e-22 | 72.5 | In-house | 1-95 (211) | alignment | ||
Range on Protein: 1-92
Range on HMM: 1-95/211.0
MS-----RTIWLVRHGQRVDNVDKKWKAnndakWDDPELTLRGKQQAHEVGKHFAN--MNIEAIVVSPFTRCIETAAQIVAMMENK-AKICVEPGLMEPL
|| ....|||||....|..... | |..|| .|..||...|...|. ....|...||..|.|.||. | . . .. |.|.|.|
MslnllmtrlyLvRHGetewnaegrlqg.....wldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErd
|
|||||||||
0049178 | Phosphoglycerate mutase-like | 1-91 | 6.9e-22 | 70.7 | In-house | 2-90 (243) | alignment | ||
Range on Protein: 1-91
Range on HMM: 2-90/243.0
MSRTIWLVRHGQRVDNVDKKWKAnndakWDDPELTLRGKQQAHEVGKHFA--NMNIEAIVVSPFTRCIETAAQIVAMMENK-AKICVEPGLMEP
| ....|||||. . |..... | |..|| .|..||...|...| .....|...|| .|.|.||. | . . . .. |.|.|.|
mmtrlyLvRHGetewnaegrlqg.....wtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrEr
|
|||||||||
0053607 | Phosphoglycerate mutase-like | 3-92 | 2e-20 | 65.6 | In-house | 2-80 (191) | alignment | ||
Range on Protein: 3-92
Range on HMM: 2-80/191.0
RTIWLVRHGQRVDNVDKKWKAnndakwdDPELTLRGKQQAHEVGKHFA--NMNIEAIVVSPFTRCIETAAQIvammenKAKICVEPGLMEPL
....|||||. . |..... |..|| .|..||. .....| .... |...||..|...||. | . .. |.|.|.|
trlyLvRHGetewnaegrlqg.......dvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii......glpvevdprlrEid
|
|||||||||
0053031 | Phosphoglycerate mutase-like | 4-125 | 1.5e-16 | 53.8 | In-house | 6-159 (342) | alignment | ||
Range on Protein: 4-125
Range on HMM: 6-159/342.0
TIWLVRHGQR--VDNVDKKWKANNDAKWDDPELTLRGKQQAHEVGKHFANM---------NIE--AIVVSPFTRCIETAAQIVAMME--NK---------
.|.||||| | ... .. .. . .....||| .|..||.|.|... .. | . . .|.. |....|. ..| . ..
vivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllg
---AKICVEPGLMEPL-----YLCKNPPTIPSMDKIKEYSTQVDESYKPVFEKL
.| .|| ...| . |.. .. . .. |. .. |.|.....||
wqpipihtepessdalllpnydpcpafdkllkealaseevkellerylellqkl
|
|||||||||
subfamily_TFC7_pd | Subfamily TFC7 | 4-124 | 1.6e-16 | 51.7 | In-house | 2-126 (255) | alignment | ||
Range on Protein: 4-124
Range on HMM: 2-126/255.0
TIWLVRHGQRVDNVDKKWKANNDA-KWDDPELTLRGKQQAHEVGKHFANMNIE--AIVVSPFTRCIETAAQIVAMMEnkAKICVEPGLMEPLYLCKNPpT
||.. ||| | . ..| .... .|. |. || .||.|.... ..... ||. ||. ||.||. |. ..| . |. |..| . . |
tiyiarhGyrsnwlpkgpypdpltgidsdvPlserGveqakelaiylkkldlkpeaifssPlyrcletskpiaeele..iPvyvdrGvgewykpdrrP.v
IPSM---DKIK-EYSTQVDESYKPVFEK
|. . .. . . ... |.. .
ilePasnevlskffPsvisldyestltp
|
|||||||||
0050036 | Phosphoglycerate mutase-like | 4-91 | 1.8e-16 | 52.5 | In-house | 2-75 (171) | alignment | ||
Range on Protein: 4-91
Range on HMM: 2-75/171.0
TIWLVRHGQRVDNVDKKWkanndAKWDDPELTLRGKQQAHEVGKHFanmNIEAIVVSPFTRCIETAAQIVammenkAKICVEPGLMEP
...|||||. . |..... | |..|| .|..||. .|... .. |...|| .|...||. | .. |.|.|.|
rlyLvRHGetewnlegrf.....qgwtdvpLtelgraqaralgell...pfdavysSpllRArqTaelil......lpvivdprLrEr
|
|||||||||
0049226 | Phosphoglycerate mutase-like | 4-124 | 2e-13 | 43.4 | In-house | 6-158 (342) | alignment | ||
Range on Protein: 4-124
Range on HMM: 6-158/342.0
TIWLVRHGQR--VDNVDKKWKANNDAKWDDPELTLRGKQQAHEVGKHFANM-----------NIEAIVVSPFTRCIETAAQIVAMMENK-----------
...|.||| | ... .. .. . ....||| .|..||.|.|... .. .. . |.. |....|. ..| . .
vqvliRHGdRtPlakgpldflnewfwgcglgeLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSaqaflaGlfppeltpilvplld
---AKICVEPGLMEPLYLCkNPPTIPSMDKIK------EYSTQVDESYKPVFEK
.| .|| ...| | . . | .||. |. .. |.......|
wqpipiitepesndtllll.pydscpnfdkllkellkseevqlfleeildllkk
|
|||||||||
0046349 | Phosphoglycerate mutase-like | 4-92 | 2.4e-13 | 43.1 | In-house | 10-123 (409) | alignment | ||
Range on Protein: 4-92
Range on HMM: 10-123/409.0
TIWLVRHGQRV--------DNVDKKWKANndAKWDDPELTLRGKQQAHEVGKHFANM---------------NIEAIVVSPFTRCIETAAQIVAMMENKA
...|.|||.| .|.. .. | ......|| .|..||.|.||.. .. .. .. |.. |....|. ..| .
vqvlfRHGaRtPtkklsflpnwpginwtn..gpcgagqLTplGreqayelGkrlrkrYvdlgLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfppl
KICVE----PGLMEPL
.. . ..|..|.
ggeivpllrqdlldpp
|
|||||||||
subfamily_Cele-STS-like_pd | Subfamily Cele-STS-like | 31-121 | 1.5e-12 | 38.3 | In-house | 49-139 (229) | alignment | ||
Range on Protein: 31-121
Range on HMM: 49-139/229.0
DPELTLRGKQQAHEVGKHFANMNIEAIV--VSPFTRCIETAAQIVAMME-NKAKICVEPGLMEplYLCKNPPTIPSMdKIKEYSTQVDESYKPV
|| || .|| ... .|. . || | || |...||| .. . ..|.| |||||.| | .. .| ..|. ||| |||.
dpPlteiGkiaskligRaLrdrgiepsvvFCSPdlrsvqtaalllkglGlkraaisvePgLle..yrkarevllppk.afkklgypvdekYkPl
|
|||||||||
0047369 | Phosphoglycerate mutase-like | 4-119 | 1.1e-11 | 37.7 | In-house | 47-208 (438) | alignment | ||
Range on Protein: 4-119
Range on HMM: 47-208/438.0
TIWLVRHGQRVD---------NVDKKWKANNDAKWDD-------------PELTLRGKQQAHEVGKHFANM-------NIEAIVVSPFTRCIETAAQIVA
...|.||| | .. ....... .... ..|| .|..|| |.||.. .. .. . |.. |....|. .|
vqvlfRHGaRtPtksklkkleplwellenattypsgplsflndwlgpcgagqLTplGreqayelGkrlrkrYglLnpedvlyvrssdvdRtlqSAqafla
MME--N-----------KAKICVEPGLMEPLYLCKNPPTIPSMDKIKEYSTQVDES----YK
. . ..| ..|. ...|. . . | .|.... . || .|
Glfppegtgelapilwqpipihtipesddfllnllpsdscpafdellkeflasdeflelllk
|
|||||||||
0048946 | Phosphoglycerate mutase-like | 5-92 | 1.5e-11 | 37.0 | In-house | 45-176 (447) | alignment | ||
Range on Protein: 5-92
Range on HMM: 45-176/447.0
IWLVRHGQRV-------------------------------DNVDKKWKANNDAKWDDPELTLRGKQQAHEVGKHFANM--------NIEAIVVSPFTRC
. |.||| | .. .. .|.. .. ..|| .|..|..|.||.. .. . . |.. |.
qvlfRHGaRtPtkkylkgleplldllknanvlelggdlsflndwkyqlkneplwpcglgqLTplGreqlyelGkrlrkrYlgllpnpseiyvrssdvdRt
IETAAQIVAMMENKA-----KICVEPGLMEPL
...|. .| . .. .. . . ....
lqSaqaflaGlfppepplgyqpipihtvpssn
|
|||||||||
0049059 | Phosphoglycerate mutase-like | 4-117 | 2.1e-11 | 36.5 | In-house | 46-200 (435) | alignment | ||
Range on Protein: 4-117
Range on HMM: 46-200/435.0
TIWLVRHGQRV--------------------DNVDKKWKANNDA--KWDDPELTLRGKQQAHEVGKHFANM-------NIEAIVVSPFTRCIETAAQIVA
.. |.||| | ... ... || ....||| .|..||.| ||.. .. . . |.. |....|. .|
vqvlfRHGaRtPtsklikklealwekllslltypngplsflndwnyplgageLTplGreqayelGkrlrkrYgfLynpdevyvrssdvdRtlqSaqafla
MMENKA------------KICVEPGLMEPLYLCKNPPTIPSMDKIKEYSTQVDES
. . .. | . ..... . .. . | .|.... . ||
Glfppeilgsqllnplnvyqpvpietvdsdndtlpydscpafdellkellasdef
|
|||||||||
subfamily_TIGAR_pd | Subfamily TIGAR | 5-90 | 4.7e-11 | 34.8 | In-house | 3-85 (222) | alignment | ||
Range on Protein: 5-90
Range on HMM: 3-85/222.0
IWLVRHGQRVDNVDKKWKANNdakwdDPELTLRGKQQAHEVGKHFANMNIEAIVVSPFTRCIETAAQIVAMMEN--KAKICVEPGLME
...||||. | | . . | |. .| .|| |.| .|..|. |. |. | .|| | .. .... ... | |
livVrhGetefnkekilqgqt.....dtpLsekGveQakrvakrLsnekinyifsSdllRAkqTaeiilkalkekkreaverdkrLrE
|
|||||||||
0048439 | Phosphoglycerate mutase-like | 5-84 | 1e-10 | 34.6 | In-house | 13-116 (391) | alignment | ||
Range on Protein: 5-84
Range on HMM: 13-116/391.0
IWLVRHGQRVDNVDKKWK-------ANNDAKWDDPELTLRGKQQAHEVGKHFA---------------NMNIEAIVVSPFTRCIETAAQIVAMMENK--A
. |.||| | .. . | . .....||| .|..|..| |... | .. . |.. |....|. .| . .
qvlfRHGaRtPtssypnkldpllnkllpngpcglgeLTplGreqlyelGrrlrkrYvdlgllpskytlnpsevyvrssdvdRtlqSAqaflaGlfpplgl
KICV
.. .
tvil
|
|||||||||
subfamily_PFKFB_pd | Subfamily PFKFB | 2-78 | 2.2e-10 | 32.3 | In-house | 6-77 (198) | alignment | ||
Range on Protein: 2-78
Range on HMM: 6-77/198.0
SRTIWLVRHGQRVDNVDKKWKANNDakwddpeLTLRGKQQAHEVGKHFANMNIEAIVV--SPFTRCIETAAQIVAMMEN
|.|.|||||. .|. .. .... || ||...|....|.... |.. . | | . | |.|| . . |.
preiylvRhGeseknkkgriggdse.......LterGveyakklakfikeenlkelrvwtselkrtiqTaellglpkeq
|
|||||||||
subfamily_PGAM5_pd | Subfamily PGAM5 | 3-92 | 3.8e-10 | 31.2 | In-house | 2-83 (189) | alignment | ||
Range on Protein: 3-92
Range on HMM: 2-83/189.0
RTIWLVRHGQRVDnvdkkwkannDAKWDDPELTLRGKQQAHEVGKHFANMNI--EAIVVSPFTRCIETAAQIVAMMENKAKICVEPGLMEPL
| . |||||| |. | . |. || .|..||...|| ....|. . .| | .| .||| |. .... | . | |
rhlilvrhgqyvl..........dddsdkkiltelGrrqaeltGkrlkelnlkftklvastmvravetadiiskqlpdvpkktktellreGa
|
|||||||||
subfamily_PGAM_pd | Subfamily PGAM | 4-79 | 7.2e-10 | 30.6 | In-house | 2-74 (248) | alignment | ||
Range on Protein: 4-79
Range on HMM: 2-74/248.0
TIWLVRHGQRVDNVDKKWKAnndakWDDPELTLRGKQQAHEVGKHFAN--MNIEAIVVSPFTRCIETAAQIVAMMENK
.. |.|||. | ..|. . | | .|. .||..|...|| . .... .. | .|...|.. |. ....
klvllRhGeselnkenkfcg.....wvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqe
|
|||||||||
subfamily_Dicty-HP1-1_pd | Subfamily Dicty-HP1-1 | 4-83 | 3e-09 | 27.0 | In-house | 2-82 (210) | alignment | ||
Range on Protein: 4-83
Range on HMM: 2-82/210.0
TIWLVRHGQRVDNVDKkwKANNDAKWDDPELTLRGKQQAHEVGKHFANM--NIEAIVVSPFTRCIETAAQ-IVAMMENKAKIC
....|||. |.. . .| | || ||.|| |. . .. ..| .. ||.|| ..|. . .. .. .|. |
kvyiirhgestfnkay..nekvdpylfdarlteegkkqanelsenvekllqdvelvisspltraldttkiallkllkeksikc
|