Gene ZK938.1 in Caenorhabditis elegans

Synonym: CELE_ZK938.1, CELE_ZK938.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP245_AA protein Get Run
CeleP245_AA_21-299 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 21-300 3.5e-180 590.2 In-house 1-280 (280) alignment
Range on Protein: 21-300
Range on HMM: 1-280/280.0
SLTHCIKEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGN
.|..||||||||.|||.||.||.||||||||.||.|||||.|||||||||.|.|.|||||||||||||||||||||||||.||.||||||||.|.|||||
tllacikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgn

HECASINRTYGFYDECKRRYSLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLLWADPENNHTGWGKNSRGVS
||..||||.|||.||.|||||||||||||.|..||||.|..||||.|||||||..|||...||...||||....|||||||||||||..|||..||||||
hevisinrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvs

YIFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKPAMREVK
.|||||||||.|||..|||||||||||||||||||||.|||.||||||.|||||.|...|||||||.|||.||||.||||
vifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpalrevk

subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 5-298 2.1e-159 522.3 In-house 4-297 (298) alignment
Range on Protein: 5-298
Range on HMM: 4-297/298.0
PNFIDKVLSVNdTSNASLTHCIKEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLM
 ... .||||. .|...||..|||.|.. .||..|.|...|...|||.|||.|||||||||.||||.|....||||.||||||||||||||.||||.||.
dellievlsvs.lsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlll

AYKVRYPNGFFILRGNHECASINRTYGFYDECKRRY-SLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLLWA
||||.||| ||.|||||||..|||.||||.|||||| ||.||.|||..||.|||.|.|.|||.|||||||..|.|..||... ||||.....||.|||||
aykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwa

DPENNHTGWGKNSRGVSYIFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKPAMRE
||||...|| .||||||..||..||||..||..|||..|.||||||||||||.|.||||||||.|||.|||.|..|.|||.|..|||.|||...|
dpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekke

subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 3-300 3.5e-133 436.4 In-house 2-299 (299) alignment
Range on Protein: 3-300
Range on HMM: 2-299/299.0
NIPNFIDKVLSVNdTSNASLTHCIKEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICL
.. ... |.|.|   |. .||...|| ..  . . .|...  ||...||.||| |||||||||.||||||.. .|||| |.||||||||||||.||.|.|
dvdellskllnvg.msekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitl

LMAYKVRYPNGFFILRGNHECASINRTYGFYDECKRRY-SLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLL
|...|..||. ||.||||||| .||| ||||.||..|| |  |.  ||. |. .||. .|..||.||||||||.| .  || .. || ||||  | .|||
llcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidll

WADPENNHTGWGKNSRGVSYIFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKPAMREVK
||||..   .|  | |||||.|| .||.|  ....|||.|| ||||||||||||.|.||||||||.|||.||| | || ||| |. .| .|||. ...|
wadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpkslk

subfamily_PPP1C_pd Subfamily PPP1C 23-296 1.1e-128 421.3 In-house 7-280 (282) alignment
Range on Protein: 23-296
Range on HMM: 7-280/282.0
THCIKEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHE
.  .|||.|  .... ..|| .|....|..||. ..|||||||.||||.|... .||..||||||||||||.| ||.|.||.|||..||. .|.||||||
evklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhe

CASINRTYGFYDECKRRYSLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLLWADPENNHTGWGKNSRGVSYI
.|||||.||||||||||||  |.. |.. || |||.|... .|.|.|||||||| |  |. || || . |.  |..||||.||.....||..|.||||. 
sasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsft

FGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKPAM
||..||..| .|...||| |.||||.|||||||...|||.||||.|||||||..... |||.|..||.||||| 
fgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpak

PP2Ac_SM00156 28-295 9.6e-113 368.7 In-house 3-270 (271) alignment
Range on Protein: 28-295
Range on HMM: 3-270/271.0
EADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHECASIN
. ..  ..||.|.||......|||.||. |.||||||..||||....  .||...|.||||||||| |..|||.||.|.|..||. ...||||||. |.|
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn

RTYGFYDECKRRYSLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLLWADPENNHTGWGKNSRGVSYIFGANV
..|||..|.||.|.  .|..|...|..|||.|... .|.|||||||||| |. ...|. |. ..|. .|..||||.|||... |. ...||.|..||...
kiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFgeda

VKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKPA
||.| .|.|..|| |.|.||..||||||||.||||||||.||.||.| | .. |.. | .|.| ||..
vkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq

subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 26-297 7.2e-109 356.6 In-house 3-276 (284) alignment
Range on Protein: 26-297
Range on HMM: 3-276/284.0
IKEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHECAS
|   |.. .. .. .|.  |  ..||..|| .|||||||..||||.|..  ||   ||||||||||||.. || | ||.|||| .|| ||.|||||||. 
ippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecsl

INRTYGFYDECKRRYSL-ALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPN-ACLAMDLLWADPENNHTGWGKNSRGVSYIF
||. ||||.||.|||   ..|  |. .|  .|| |..  ||.|||||.|  |   .||  | |||| |.   ||.|.||.|| | . ||  |||||||.|
inkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvf

GANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKPAMR
|.. .. . ....|||. | ||||||||||||..||||||||| |||.||| | .| |.. |. || .|.|  .
gsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkk

subfamily_PPZ_pd Subfamily PPZ 2-294 4.7e-107 350.9 In-house 1-293 (300) alignment
Range on Protein: 2-294
Range on HMM: 1-293/300.0
VNIPNFIDKVLSVNDTSNASLTHCIKEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVIC
|.| . |.|.|    ... .   |.|...|  .  ...... || ...|.  .. . ||.||||.||||.| .| |||  ||||||||||||.| || | 
vdideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletil

LLMAYKVRYPNGFFILRGNHECASINRTYGFYDECKRRYSLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLL
||..||..||. ||.|||||||| . | ||||||||||  . ... | . ||.|||.|...|.|||.|||||| | |  .. ...|| | |.  |  |||
lllcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindll

WADPENNHTGWGKNSRGVSYIFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKP
|.|| ..   |  | ||||| .    .. | .|. .||..| | ||.|||||| |. |||.||||.|||||||   .| | | |. |||.| |
wsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp

0045823 Metallo-dependent phosphatases 24-299 1.8e-106 349.5 In-house 41-328 (473) alignment
Range on Protein: 24-299
Range on HMM: 41-328/473.0
HCIKEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHEC
  ..| |.  ...|.|.||. . ...|....|.|.||||||..||||..... |||.....||||.|||| . |||..||.|.|..||. .|.||||||.
gllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHEl

ASINRTYGFYDECKRRYSLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLLWADPeNNHTG--------WGKN
. .|  |||.||. ..|.  ||.||.....||||.| | |.|...||||||.| .. |...| ||...|. .|..||||.||  .  |        .| .
rllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddgdgllrlrffgns

SRGVSYIFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKR------LVTIFSAPKYCGEFDNNAGIMIVDERLiISFEILKPAMREV
 ||..|.||...|..| .|...||| |||..|..|||.. |..      ..|.|||| |||...| |.....|| | ||| ...|.  ..
prgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphpl

subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 6-295 1.3e-104 342.7 In-house 4-295 (297) alignment
Range on Protein: 6-295
Range on HMM: 4-295/297.0
NFIDKVLSVnDTSNASLTHCIKEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMA
. |  |||   | .  |.. | |  .  ... . |.. || .||||.||| ||||||||. ||||.| |  .||  |||||||||||||  .| | ||.|
siiidvlsa.sthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivllla

YKVRYPNGFFILRGNHECASINRTYGFYDECKRRY-SLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSP---ELVSWTQLAKIIRPFDPPNaCLAMDLL
|||..|  .|.|||||||  .|..||||.||..|| |. .|  ||..|| |||. .|. .|.||||||||   . ..   | || |. .  .  |  |||
ykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegke.rlvadll

WADPENNHTGWGKNSRGVSYIFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKPA
||||    .|. .| ||    || . | .   ....||..| |||||||||||| ..||||||||.|||.||| | .| .||.|  |||||.|.
wadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt

subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 27-295 8.2e-103 336.7 In-house 9-283 (284) alignment
Range on Protein: 27-295
Range on HMM: 9-283/284.0
KEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFP------PDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGN
|| ..  .   .....  .   .|..||. ..||||||. ||| ...   .|       ...|||||||||||   .||| ||.|||...|.  |.||||
kekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgn

HECASINRTYGFYDECKRRYSLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLLWADPENNHTGWGKNSRGVS
||   .|. |||| |||.||| |||. ||  ||..||||..| .|.|||||.| .|.. .|| |. ||.| |.  .  || |||||.. .|. .  ||  
hesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprgag

YIFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKPA
 .|||. ||.|..|...||. | ||||.||||||||..|||||||| |||..|| | .. ||| |..|| .||| 
kvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkpd

0049330 Metallo-dependent phosphatases 22-296 9.7e-103 336.4 In-house 26-300 (309) alignment
Range on Protein: 22-296
Range on HMM: 26-300/309.0
LTHCIKEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNH
 .....| ..  .....|.||  . ...|....|.|.||||||..||||..... |||.....||||.|||| . |||..||.|.|..||...|.|||||
klkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvfllrGNH

ECASINRTYGFYDECKRRYSLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLLWADPENNHTGWGKNSRGVSY
|.. .|. |||.||..|.|.  |..||.....||||.| | |.|.|.||||||.|... |.... ||...|.  | .||||.|| . . |...| ||...
ElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpiregfapnprglgv

IFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKPAM
.||...|..| .| ..||| |||..|..||..|.|..|.|.||||.|||...| ......|| | ||| ...|. 
vfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvp

subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 23-297 2.8e-102 334.5 In-house 7-284 (287) alignment
Range on Protein: 23-297
Range on HMM: 7-284/287.0
THCIKEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHE
...... ||  |.|. ..||    ...||.|||...||||||. ||||||| .  .|. .||||||||||| . |||. ||...|..||.   .||||||
ldafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhe

CASINRTYGFYDECKRRYSLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPfDPPNAC---LAMDLLWADPENNHTGWGKN-SRG
.  ||..|||..| ||...  ||..|...|. |||||..| ||.|||||.||.| |. .|  . .|   | ||   | .||||||||..  .   |  |.
vkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkp.ttplacdeglqvdllwadpekdaktfelnkira

VSYIFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKPAMR
.| .|| ..| |. .|..|||| | |.|...||.|..||||||.||||.|.||  | . .. |.. | .||  |||   
isvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedf

PPP_3 26-293 4e-101 330.6 In-house 2-270 (271) alignment
Range on Protein: 26-293
Range on HMM: 2-270/271.0
IKEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHECAS
..| ... .....|.||. ....||..||. ||||||||..|||..|. . ..|...||||||||||| . |||..||.|.|..||. ...||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INRTYGFYDECK-RRYSLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLLWADPENNHTGWGKNSRGVSYIFG
||..|||..|.. ....  .|...|..|. |||.|.|.......||||||.. |. |. |. |. . |. .. .|||. .......|.....||....||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

ANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILK
..|...| ||....||.| |.....|||...|...||.||||.||....| . |. ..|.|  .|..|.
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle

subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 28-295 4.1e-97 317.8 In-house 10-277 (281) alignment
Range on Protein: 28-295
Range on HMM: 10-277/281.0
EADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHECASIN
. .|  || | . |.| . ..||...||.| ||.|.|..|| |.|.  . .|.. ..||||||||| | |||. ||...|.||..  ..|||||| ||.|
keeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvn

RTYGFYDECKRRYSLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLLWADPENNHTGWGKNSRGVSYIFGANV
. |||| ||. .|   |. .||. || ||. |.|. |. ||||||||||..  .| .. .| ....  | .|||||||.|.  .| . |||.|..|| ||
kiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknv

VKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKPA
|.|   .....|| |.||||||||| .. ..|.|.||.|.||  . | | .. ||| | ||.  | ||
vddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpa

PPP_1 28-279 1.7e-96 315.6 In-house 3-262 (264) alignment
Range on Protein: 28-279
Range on HMM: 3-262/264.0
EADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHECASIN
|. .  .... |..|. . ...||...| ||||||||..|||..|. . ..|..|||||||||||| . .|...||.|.|..||. .|.||||||.....
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

RTYGFYDECK-RRYSLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLL-------WADPENNHTGWGKNSRGV
..|||..|.. ..||  .|. ....|. |||.|.| ..|...|||||||| .  |  |. |  . |. . ..|||       . |........ .. ||.
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

SYIFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIM
.|.||..|...| .| |..||.| |.|...||||......||||||. |. |..|.. ..
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayv

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 81-295 1.7e-96 316.1 In-house 101-315 (317) alignment
Range on Protein: 81-295
Range on HMM: 101-315/317.0
QNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHECASINRTYGFYDECKRRYSLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWT
..|||||||||||   .||. ||.|.|..||.  |.||||||  ..|. |||| |.|.||| |||. ||. || |||||... .|.|||||.| ||.. .
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QLAKIIRPFDPPNACLAMDLLWADPENNHTGWGKNSRGVSYIFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMI
|| |. ||.| |.  .  || ||||... .|. . .|| . .|||. ||.|..|...||. |.||||.||||||||..||||||||.|||..|| | .. 
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDERLIISFEILKPA
||. | ||...|.| 
vdkklkisinvlrpe

0053225 Metallo-dependent phosphatases 23-295 8.9e-96 313.6 In-house 19-291 (293) alignment
Range on Protein: 23-295
Range on HMM: 19-291/293.0
THCIKEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHE
. ...| ..  ...|.|.||. . ...|....|.|.|||||...|||...... |||. ...||||.|||| . |||..||.|.|..||.....||||||
lkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNHE

CASINRTYGFYDECKRRY-SLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLLWADPEnNHTGWGKNSRGVSY
.. .|  |||.||..|.| . .|..|......||||.| | |.|...||||||.|... |...| ||...|.  | .|||| ||    .||... ||...
lmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.lwsgwlpsyrglgv

IFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKPA
.||...|..| .| ..||| ||||||.|||... |..|||.||||.|.|...| ......|| | ..| ...| 
vfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv

subfamily_PPP4C_pd Subfamily PPP4C 23-295 8.1e-88 287.4 In-house 13-285 (288) alignment
Range on Protein: 23-295
Range on HMM: 13-285/288.0
THCIKEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHE
.. ||| ..  . .. ..||  .. . .|..|. ||||||||. |||..|.     |..|||||||.||||   .| . ||.|.|||||.   ..|||||
celikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhe

CASINRTYGFYDECKRRY-SLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLLWADPENNHtGWGKNSRGVSY
. .| ..||||||| |.| | ....   ..|. |.|.|.| |.|||.||||||.. .  ..  | |  . |.     ||||.|||. . ||.   ||  |
srqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae.gwavsprgagy

IFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKPA
.||..||..|.|. .|.||.| ||.|..|| .  .....|..||| ||    | | |. .||.|   |.|.. |
lfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaa

subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 29-294 3.6e-87 285.4 In-house 9-274 (280) alignment
Range on Protein: 29-294
Range on HMM: 9-274/280.0
ADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHECASINR
 .|  .|   . |.  .. ..| .||| | |||| || |. |.|.     |... .||||||||| | .||. ||.. |.|| .  ..||||||  |.|.
heiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnk

TYGFYDECKRRYSLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLLWADPENNHTGWGKNSRGVSYIFGANVV
 |||| ||. .| ..|. .||. || .|....|| |..||||||||||.    . .| || .| .  | .||||.|| |.  || .. ||.||.||  ||
iygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvv

KDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKP
..  . ..|||| |.|||||||||..| .||.|.|| |.|| .| | | .....  | .||. | |
eqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlip

subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 22-296 5.7e-87 284.4 In-house 12-290 (290) alignment
Range on Protein: 22-296
Range on HMM: 12-290/290.0
LTHCIKEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNH
 ...... ||  ..|. ..||    ...||.|||.. ||||||  .||| |.   .||. ..|||||||||| . |||  ||. ||.||..   .|||||
vldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnh

ECASINRTYGFYDECKRRYSLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPP--NACLAMDLLWADPEN--NHTGWGKNSR
|.  .|| |||..|  |. .  |.. .|..|. |.||| .. .|.|||||.|... ||  |  . .|  |   .  | .|||||||..  ..|   .  |
evrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqr

GVSYIFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKPAM
..| .|| ... |. .|. ..|| | |.| ..|..|  ||.|||.|||| |.|.  |   |. | | | .|. .||| .
aisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkprk

subfamily_PPP2C_pd Subfamily PPP2C 24-298 7.7e-87 284.1 In-house 15-289 (290) alignment
Range on Protein: 24-298
Range on HMM: 15-289/290.0
HCIKEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHEC
. ..|...  ..|. |.||| .. . ||..|..||||.|||. ||| .|.     || ||||||||||||   .| ..||.| ||||..   ||||||| 
kqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhes

ASINRTYGFYDECKRRYSL-ALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLLWADPEnNHTGWGKNSRGVSYI
  | . ||||||| |.|.  .... | .||. |||.|.. ..|||.||||||.. .  .. .. |  . |.     ||||.||. . .|||   ||  | 
rqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagyt

FGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKPAMRE
|| .. ..| .. .. |||| ||.| .||..  |...|||||||.||    |.|.|. .|..|  ||   .|| |.
fgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr

subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 48-300 2.5e-80 262.9 In-house 2-261 (263) alignment
Range on Protein: 48-300
Range on HMM: 2-261/263.0
MVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHECASINRTYGFYDECKRRYSL-----
..|.|||| .||| |||| ||||||| |      .||||||||||| . |||| ||.. |.  |  ...||||||  .||. |||. | |.|.       
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

ALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPN-ACLAMDLLWADPENNHTGWGKNS-RGVSYIFGANVVKDFTEKMNIDLI
..|| |...|. .||||..| ||.|||||.|| | |  ..  |  |..  .   || ||||||||..  |.  |  | .| .|| . | |. ....||||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

ARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKPAMREVK
 | ||||. || ||||.||.|.||| .|  |. | | ...|.. | .||  |||   ||.
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpedfevr

subfamily_PPP6C_pd Subfamily PPP6C 24-286 1.4e-78 257.0 In-house 13-275 (290) alignment
Range on Protein: 24-286
Range on HMM: 13-275/290.0
HCIKEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHEC
. . |.|.  . .  .|.|. ..... |..|..||||||||. ||. .|.     ||..|.||||.||||   || . .|.. |..||.   .||||||.
kylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhes

ASINRTYGFYDECKRRYSLA-LYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLLWADPENNhTGWGKNSRGVSYI
  | . |||||||...|  |  .. . ..|. |...|.| ....|.||||||..    |.  | |  . |.     ||.|.|||.    |   .||  |.
rqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedv.etwavsprgagyl

FGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLI
||..|.|.|..  |..||.| ||.|..|.... |..|||..||| ||    | | |.....   
fgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaee

subfamily_PPP5C_pd Subfamily PPP5C 34-285 2.5e-77 253.0 In-house 42-299 (322) alignment
Range on Protein: 34-285
Range on HMM: 42-299/322.0
VIEECKDILSAQATMVEVQAP----IAVCGDIHGQYTDLLRIFNRCSFPP-DQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHECASINR
.. | |..|......||.. .    ..||||||||. ||| ||.    |  .. ||| ||.||||   .||| .|...|. ||| ||. |||||  ..|.
illeakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnk

TYGFYDECKRRYSLALYNEFQNLFNSLPLCAMISGRIFCMHGGL-SPELVSWTQLAKIIRPFDPPNACLAMDLLWADPENNhTGWGKNSRGVSYIFGANV
 ||| .|.| .|. .... |...||.|||. .|  ... .|||| | . |.  .| || |  .||.  | ..|||.||... .| .. .|||.  || .|
lyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqea.nGrspskrGvgvqfGpdv

VKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIV-DERL
 | | .. |..|| | |.| ..|||.  | .|.|.|||| || . .| .... . .. |
tkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddl

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 82-299 1.5e-76 250.7 In-house 121-338 (339) alignment
Range on Protein: 82-299
Range on HMM: 121-338/339.0
NYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHECASINRTYGFYDECKRRYSLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQ
 |||||||||||   .||. || | |. ||.  ..||||||  |.| .|||| | . ||   ||. |||.|| .|.||.|   |.|||||.|  | |. |
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

LAKIIRPFDPPNACLAMDLLWADPENNHTGWGKNSRGVSYIFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIV
.. . ||.. |.  .  || ||||.    |.   .|| |..||   .. | .|...... ||||||.||||||  .|||||||||.|||. || | .. .
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DERLIISFEILKPAMREV
|..| || ....|  |. 
dkklkisinvfrpesrdk

subfamily_PPP3C_pd Subfamily PPP3C 26-284 2e-75 247.3 In-house 41-312 (452) alignment
Range on Protein: 26-284
Range on HMM: 41-312/452.0
IKEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHECAS
..|...  .|||. ..|. . |..||.|||.|.||||||. |||..|.    | ...|||||||||||   .|..  |.| |. ||. .|.|||||||  
leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrh

INRTYGFYDECKRRYSLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLLWADPENNHTG------WGKN-SRG
.   . | .||| .|| ..|... . |.|||| |.. .. .|.|||||||. |  .. |. |  .||.  .  ||||.|| ...        . .|  ||
lteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvrG

VSYIFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFAD------KRLVTIFSAPKYCGEFDNNAGIMIVDER
 ||... . | .| .| ..  | | |.. ..||. . .        |.|.|||| |.. ..| | .. ... 
csyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn

subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 24-298 7.4e-73 238.4 In-house 19-295 (307) alignment
Range on Protein: 24-298
Range on HMM: 19-295/307.0
HCIKEaDIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHEC
.  || ... || |.. |.|.. ..|... |  | ||.|||. ||. .|     ||.  |.| |||||||   ||.| ||..||. ||.   .|||||| 
qytke.efenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnhei

ASINRTYGFYDECKRR---YSLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLLWADPENNHTGWGKNSRGVS
| .|. ||||.||          ..  ||  || ||. |.|. .|.|||||||| |    .| .  .|   |   .  |.|||||.     |   |||  
arvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsg

YIFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKPAMRE
. ||.||. |   .. ..|| | ||.. |||  .. ..|.|||||| ||  . |   .. ||| | |    . |.  .
ftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpesen

subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 28-294 1.1e-72 237.7 In-house 8-299 (302) alignment
Range on Protein: 28-294
Range on HMM: 8-299/302.0
EADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRC------------SFPpDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFF
. ..  .||.  . |. . |..|. .|... ||||||. ||.||.|              ||   . ..|||||||||.. .| |||..|.|| ||. . 
ksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfs.sdkfvflGdyvdrGsksieciclvfalkvlyptnyi

ILRGNHECASINRTYGFYDECKRRYSLA----LYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDP-PNACLAMDLLWADPENNH-
.||||||. .|| .||| .| . |.. .    ....|.. |  .|| |..  .|.|.|||.|| | |. .. || ||.    .  || |||.||| . . 
llrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvql

-------TGWGKN-SRGVSYIFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKP
         . ||  ||.|..|    |.|. ...|..|| |.||..  |. |||||.|.||||||.|  | ||.  .. ||    .|  .|..
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn

subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 27-293 2.3e-72 236.7 In-house 8-299 (302) alignment
Range on Protein: 27-293
Range on HMM: 8-299/302.0
KEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRC------------SFPpDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGF
.. ..  .||.  . |. . |..|. .|... ||||||. ||.||.|              ||   . ..|||||||||.. .| |||..|.|| ||. .
sksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfs.sdkfvflGdyvdrGsksieciclvfalkvlyptny

FILRGNHECASINRTYGFYDECKRRYSLA----LYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDP-PNACLAMDLLWADPENNH
 .||||||. .|| .||| .| . |.. .    ....|.. |  .|| |..  .|.|.|||.|| | |. .. || ||.    .  || |||.||| . .
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

--------TGWGKN-SRGVSYIFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILK
          . ||  ||.|..|    |.|. ...|..|| |.||..  |. |||||.|.||||||.|  | ||.  .. ||    .|  .|.
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr

PPP_2 55-246 3.3e-72 235.3 In-house 1-197 (198) alignment
Range on Protein: 55-246
Range on HMM: 1-197/198.0
IAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHECASINRTYGFYDECK-RRYSLALYNEFQNLFN
. ||||.|||..|||..|. . ..|...|||||||||||.. |||..||.|.|..||. ...||||||....|..|||..|.. .... ..|...|..|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

SLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLL----WADPENNHTGWGKNSRGVSYIFGANVVKDFTEKMNIDLIARGHQV
 |||.|.|.......|||||.|. ...|  |. |. . |. .. .|||    . ||....... ...||....||..|.....||....|| | |.|
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev

subfamily_PPG1_pd Subfamily PPG1 26-295 2.9e-71 233.2 In-house 14-296 (300) alignment
Range on Protein: 26-295
Range on HMM: 14-296/300.0
IKEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHECAS
. |. .  ...  |..|  .. ..|...|..| ||.|||. |.| ||.     || ||||||||||||   .| | ||.. |.|||    .||||||   
lpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrq

INRTYGFYDECKRRY--SLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPPNACLAMDLLWADPE--NN-------HTG--W
| ..|||| || |.|     ... . ..|. | |.|.|   |.|.||||||.  |  |.  . |  . ||     ||||.|||  ||       . |  .
itqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhf

GKNSRGVSYIFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNAGIMIVDERLIISFEILKPA
 .  ||  | .| .||. | .. ... | | ||....||. . |..| |..|||.||    | | |. . |..   |.. . |
vvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeea

PPP_4 55-246 2.2e-69 226.4 In-house 1-196 (197) alignment
Range on Protein: 55-246
Range on HMM: 1-196/197.0
IAVCGDIHGQYTDLLRIFNRCS-FPP-DQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHECASINRTYGFYDECKRRYSLALYNEFQNLF
. |.||||||..||| .. ... .|. ...|.||||||||| . |||..||.|.|..||. ...||||||..|.|. |||..|......  .....|..|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

NSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPP-NACLAMDL-LWADPENNHTGWGKNSRGVSYIFGANVVKDFTEKMNIDLIARGHQV
. |||.|.|.......|||||.|| |.... .| |... | . ....|| ||.||.....|. .. ||....||..|...| || |..|| |.|..
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel

PPP_5_Dcr2 55-247 6.1e-68 221.7 In-house 1-199 (199) alignment
Range on Protein: 55-247
Range on HMM: 1-199/199.0
IAVCGDIHGQYTDL-LRIFNRCSFPP-DQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHECASINRTYGFYDECKRR-YSLALYNEFQNL
. ||||.|||. || |..|... .|. ...|.|||||||||...|||..||.|.|..||. ...||||||. ..|. |||..|.... ..  .|. ....
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FNSLPLCAMISGRIFCMHGGLSPELVSWTQLAKIIRPFDPP-NACLAMDL-LWADPENNHTG-WGKNSRGVSYIFGANVVKDFTEKMNIDLIARGHQVV
|. |||.|.|.......|||||||. |...|.|| |... | .    .|| ||.||.....| . .. ||....|| .|...| || |..|| |.|...
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk

subfamily_PPPLV_pd Subfamily PPPLV 36-284 4e-53 173.6 In-house 7-278 (290) alignment
Range on Protein: 36-284
Range on HMM: 7-278/290.0
EECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRI---FNRC-SFPPDQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHECASINRTYG
.   ||| |.  ..|...|. | ||.||.| ||  .   . |        ..||||||||||   .|.|. |.| || ||  ...||||||  |.  .. 
dvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesie

FYDECKRRYSLAL---YNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLAK---IIRP--FDPPNACLAMDLLWADPENN-----------HTGW
.. |.. ..   |   .. |.| |. ||| |.|  ..||.|.|.     . ....    |.     |   | ||.|.||.||...             |.
ykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGf

GKN-SRGVSYIFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEfDNNAGIMIVDER
 .| .|| ...|... .. | .. |.. . | |.| . |...  . ||.|.||. .|||   |.| ...||..
vdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvdkk

Metallophos Calcineurin-like phosphoesterase 54-247 2.7e-42 138.3 Pfam-A 2-199 (200) alignment
Range on Protein: 54-247
Range on HMM: 2-199/200.0
PIAVCGDIHGQYTDL----LRIFNRCSFPPDQNYLFLGDYVDRGRQQLEVICLL--MAYKVRYPNGFFILRGNHECASINRTYGFYDECK----------
.|.|.||.||.. ||    |.... .. .. ...|||||.||||.  .|...||   ..|...|. .| ||||||. ..|  |||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------RRYSLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSPELVSWTQLakiirpfdppnaclamdllwadpennhtgwg
                         ..    . |... |. |||.| . |.|...||.||... |...                                
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

knsrgVSYIFGANVVKDFTEKMNIDLIARGHQVV
      |. || ... .. || ..||. |||. .
.....gselfgpdalekllekygvdlvlrGHtHk

subfamily_PPP7C_pd Subfamily PPP7C 35-184 5.3e-36 117.1 In-house 42-198 (383) alignment
Range on Protein: 35-184
Range on HMM: 42-198/383.0
IEECKDILSAQATMVEVQ----APIAVCGDIHGQYTDLLRIFNRCSFPP-DQNYLFLGDYVDRGRQQLEVICLLMAYKVRYPNGFFILRGNHECASINRT
. |.|..| .   . .|.      ..||||.||.  ||| |. .  .|  ...|.| ||.||||.. .|....|.|. . ||. ... |||||   .|  
lreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlr

YGFYDECKRRY---SLALYNEFQNLFNSLPLCAMISGRIFCMHGGLSpELVSWTQLAK
|||  | . .|   .  . . ....|  |||...|  .|. .|||.| .  . . | |
yGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldk

subfamily_PPP7C_pd Subfamily PPP7C 198-276 1.8e-17 56.2 In-house 238-316 (383) alignment
Range on Protein: 198-276
Range on HMM: 238-316/383.0
MDLLWADPENNHTGWGKNSRGVSYIFGANVVKDFTEKMNIDLIARGHQVVQDGYEFFADKRLVTIFSAPKYCGEFDNNA
.|.||.||....  .    ||    ||..| |.. .| |..|. | |.  ..||||  ||...|||||  |  |  |  
ldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrG

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 25-78 1.8e-09 30.2 In-house 8-61 (317) alignment
Range on Protein: 25-78
Range on HMM: 8-61/317.0
CIKEADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFP
 .||...  .    ....  .  ..|..||....||||||. ||| ...   .|
lfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp

subfamily_YNL217W_pd Subfamily YNL217W 55-175 1.5e-08 27.4 In-house 12-139 (235) alignment
Range on Protein: 55-175
Range on HMM: 12-139/235.0
IAVCGDIHGQYTDLLRIFNRCSFPPDQN--YLFLGDYVDRGRQQLEVICLLmaykvRYPNGfFILRGNHECASIN------RTYGFYDE--CKRRYS--L
. | ||.|| | .|.....      |.|   ...|| ...| ...||. ..     |  ..   ..|||| . .       .  |. .    ..     .
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv.....rkdqv.kcvkGnheelvllaykwvkkpkgaeplefsskfsfles

ALYNEFQNLFNSLPLCAMISG-RIFCMHGGLSPE
.| ..  ..  .|.    |..  .. .|.||.| 
klskadmeyarelgfsldipsdellvvhaGlvpg

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 29-78 1.7e-06 20.4 In-house 14-63 (339) alignment
Range on Protein: 29-78
Range on HMM: 14-63/339.0
ADIDGVIEECKDILSAQATMVEVQAPIAVCGDIHGQYTDLLRIFNRCSFP
|..  .   ..... ..  .....|||.| ||||||. ||| ...   .|
aelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwp