Gene alp in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold AP
Superfamily AP
Family AP
Subfamily AP
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP001_AA protein Get Run
DdisP001_AA_80-550 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_AP_pd Subfamily AP 94-547 7.4e-131 427.7 In-house 14-470 (472) alignment 
Range on Protein: 94-547
Range on HMM: 14-470/472.0
LLIVFLLPrgwEGPKKKTNIIMMIGDGMGPAALTMARVCFHT-KGESTSQAHLHLDPY-IVGTVKTYSSNSVVTDSAAAATAYASGVKTYNNAVGVDAN-
|   . |.   .  ||..|.|...|||||....|.||.. .. |||....|.|.|. . .||..|||||...|.||||.||||..||||.|...||||. 
lkealelq...snskkakNvilflgdGmgvstvtaaRilkgqlkgelgeeasLaleeFpyvglsktyssdkqvpdsaatAtAylcGvktnngtiGvdaav

---------GKPAGTIIEAAKKLGMKTGLVVTTRISDATPACYFAHSATR---HDEAF-----------IIDQLL----DKEIDVILGGGKQFFSNKTLQ
         ||....|.||||| |..||||.|||...|.||...||.|.|   .||..           |..||.    .||.|||||||.. |..|| .
erkdCeasagkevdsileaAkkaGkatGlVtttrvthAsPaglyahvanRnwesdeevpaeaekegckdiaqQLieeevgkeldvilGGGrkkflpktvk

DA------------------VSSKYNYSYVESKQEMEQV---EAGRILGLFADYNIPWEIDRlrDPTLlstKPSLQEMTTKALNLISQnNENGFFLMVEG
|.                   ..|.|..|||...|.|.|   ...|.||||||.....||||  |..    .|||.|||.|||...|. |||||||.|||
dseyekkgerkDgrnLieewekekknakyvenrkelenvdksktdrllGlfadshlkyeidr..deke...ePsLkemtekAlevLsk.nenGffLfVEg

SKIDVAAHINDAPTQIWETDAFDQTFNLVREWAEKdGNTIVIVTADHetggltlANQMVIDGNPKYSWSPETLLTVNKSADLMAELIkggadptkLIFDN
..||.|.| |.| ....|| .||....|..|....  .|...|||||       .....|.|.||...|...| . .|||| .....        |...|
grIDhahhenkakkaleetlefdeavelaleltde.edTlivvtaDH.......shtltiagypkrgssilglakesksadelpytt........lsyan

-TGYTLTSDDLKEiNRTKSAYYLNQVIGRIVSNYAdIGFTTGGHTGEDVNLYTFGDTISegkfetrlkdhqteivdnyidpILRGNINNIDIASFIIKTL
 .||.||..||.| ...|....... . ..||..| .......|.||||..|..|   .                      .|.|.... .||... ...
gpgyeltesdlee.gerkdlteaeteakdyvsqaa.vpleeetHggeDvavyasGpqsh......................lltGvveqstiahvmayaa

NLDIQS
.|. ..
clgeae
0037220 Alkaline phosphatase-like 81-550 2.4e-120 392.7 In-house 4-475 (479) alignment 
Range on Protein: 81-550
Range on HMM: 4-475/479.0
YILTSLAILVTVVLLIVFLLPRGWEGPKKKTNIIMMIGDGMGPAALTMARVCFH-TKGESTSQAHLHLDPY-IVGTVKTYSSNSVVTDSAAAATAYASGV
..|..| .|....| ...|. . .  ..|. |.|..||||||.. .|.||.  . ..|..  . .|.|| . .||.|||||..|.||||||||||.|.||
llllllllllllalallllalllllnkskaknvilfigDGmgvstvtaariylgqllgglgeegllaldkfplvglvkTysvdslvtDSAaaaTAlatGv

KTYNNAVGVDAN----------GKPAGTIIEAAKKLGMKTGLVVTTRISDATPACYFAHSATRHDEAFIIDQLLD---------------KEIDVILGGG
||.|.|.||||.          |.| .||.|.||..|..||||.||||..||||...||.| |. |  |  |||.               . .|||||||
KtnngaigvdadvsrdncddplgnpvetilelakeaGkatGlVtTtrithATPAafyAhvanRnweddialqllgleagckdiatqlvlgsgldvilGGG

KQFFSNKTLQDAVS----------------------SKYNYSYVESKQEMEQVEA----GRILGLFADYNIPWEIDRlrdptLLSTKPSLQEMTTKALNL
 ..| .|.  |  .                       | .|.|| ...|......    ...|||||| ..|.|.||       |. ||| ||| |||.|
rkyflpkgtldpeydlelllggkrldgrdlleeakekkkgytyvtnreeldaldlgsnvdkllGlfadshlpyeldr.....daseePsLaemtekAldl

ISQnNENGFFLMVEGSKIDVAAHINDAPTQIWETDAFDQTFNLVREWAEkDGNTIVIVTADHETGGLTLANQMVidGNPKYSWSPETLLTVNKSADLMAE
.|. |..||||||||..|| |.| ||| ....|. |||.......|.|. |..|.|.|||||..|||.| ..    ||| . ..|. ||.. ....|.  
Lsk.ndkGFfLmvEggriDhagHandaaaalgevlafdeaveaalefak.dddTlvvvtADHshgglilgyadr..gnpilgllpgllldglpyttllya

LIKGGADPTKLIFDNtgytltsddlkeinrtksayYLNQVIGRIVSNYADIGFTTGGHTGEDVNLYTFGDTisEG-KfetrlkdhqteivdnyidpilRG
...| .  ..|..|                     .| ..........| .|.|.||||||||..| .|    .                        .|
ngpgflllldlrldl....................tllvtlallllqralvgwtsggHtgedVpvyayGpg..aelf.....................lg

NINNIDIASFIIKTLNLDIQSITE
...|.||| .|.. |.|...... 
vyentdiahviasalglgllevll
Alk_phosphatase Alkaline phosphatase 111-540 3.4e-99 323.2 Pfam-A 2-418 (421) alignment 
Range on Protein: 111-540
Range on HMM: 2-418/421.0
TNIIMMIGDGMGPAALTMARVCFHTKGESTSQAHLHLDP-YIVGTVKTYSSNSVVTDSAAAATAYASGVKTYNNAVGVDANGKPAGTIIEAAKKLGMKTG
 |.|..||||||.. .|.||   . . ... .  |.||  ..||. |||.... ||||||.|||||.||||||.|.||| .||.. ...||||| | .||
knvilligDGmgvstvtaaRslkeqakgklgeeilaldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvdthgkevksvleaAkkaGkstG

LVVTTRISDATPACYFAHSATRHDE---AF-----------IIDQLLDKE--IDVILGGGKQFF----------------SNKTLQDAVsSKYNYSYVES
||.|||. .|||| ..||.| |. |   |            |..||....  |||.||||.. |                 ...| . .  |  |.||. 
lVtTtrvthAtPaalvahvasRkweddaataasakkeGkkdiaeqlikakkkidvllGGGrkeflptgtkdeekerGtrldgrnlieea.kkagyqyvsd

KQEMEQVEAGR----ILGLFADYNIPWEIdrlrdPTLLSTKPSLQEMTTKALNLISQNNeNGFFLMVEGSKIDVAAHINDAPTQIWETDAFDQTFNLVRE
..|. ...  .    .|||||| ... |.     .   ...|||.||| .|..|.|.|. .||||.||||.|| ||| |||  .. |. .||. .. . |
rkeLlkakeensvkplLGLFadgdlkvel.....erdekeePsLkemtevAiklLskne.kGFFLlVEGsrIDhaaHendavgalsEvvefdeAvkaale

WAEKDGNTIVIVTADHETGgltlanqMVIDGNPKYSWSPETLLTVNKSADLMAELI-KGGADPTKLIFDntgytltsddlkeinRTKSAYYLNQVIGRIV
 |.|. .|.|.|||||...       ..| |.... .|.| | ...|. | .|. . . |  . . . |               ...     .. . .|.
fakkeketlvvvTaDHshv.......fsiggytqrgtsieglaaakktkdgkakklilygngegakved...............garenvtaeealekiy

SNYADIGFTTGGHTGEDVNLYTFGDTISegkfetrlkdhqteivdnyidpILRGNINNIDIASFIIKT
.. ...|.|. .||||||...  | . .                       .||.... .|| .. . 
rkrsavgltseeHtgedvavfAygpkae......................lvrGvqeqteiakvlaaa
Alk_phosphatase Alkaline phosphatase 111-540 3.4e-99 323.2 In-house 2-418 (421) alignment 
Range on Protein: 111-540
Range on HMM: 2-418/421.0
TNIIMMIGDGMGPAALTMARVCFHTKGESTSQAHLHLDP-YIVGTVKTYSSNSVVTDSAAAATAYASGVKTYNNAVGVDANGKPAGTIIEAAKKLGMKTG
 |.|..||||||.. .|.||   . . ... .  |.||  ..||. |||.... ||||||.|||||.||||||.|.||| .||.. ...||||| | .||
knvilligDGmgvstvtaaRslkeqakgklgeeilaldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvdthgkevksvleaAkkaGkstG

LVVTTRISDATPACYFAHSATRHDE---AF-----------IIDQLLDKE--IDVILGGGKQFF----------------SNKTLQDAVsSKYNYSYVES
||.|||. .|||| ..||.| |. |   |            |..||....  |||.||||.. |                 ...| . .  |  |.||. 
lVtTtrvthAtPaalvahvasRkweddaataasakkeGkkdiaeqlikakkkidvllGGGrkeflptgtkdeekerGtrldgrnlieea.kkagyqyvsd

KQEMEQVEAGR----ILGLFADYNIPWEIdrlrdPTLLSTKPSLQEMTTKALNLISQNNeNGFFLMVEGSKIDVAAHINDAPTQIWETDAFDQTFNLVRE
..|. ...  .    .|||||| ... |.     .   ...|||.||| .|..|.|.|. .||||.||||.|| ||| |||  .. |. .||. .. . |
rkeLlkakeensvkplLGLFadgdlkvel.....erdekeePsLkemtevAiklLskne.kGFFLlVEGsrIDhaaHendavgalsEvvefdeAvkaale

WAEKDGNTIVIVTADHETGgltlanqMVIDGNPKYSWSPETLLTVNKSADLMAELI-KGGADPTKLIFDntgytltsddlkeinRTKSAYYLNQVIGRIV
 |.|. .|.|.|||||...       ..| |.... .|.| | ...|. | .|. . . |  . . . |               ...     .. . .|.
fakkeketlvvvTaDHshv.......fsiggytqrgtsieglaaakktkdgkakklilygngegakved...............garenvtaeealekiy

SNYADIGFTTGGHTGEDVNLYTFGDTISegkfetrlkdhqteivdnyidpILRGNINNIDIASFIIKT
.. ...|.|. .||||||...  | . .                       .||.... .|| .. . 
rkrsavgltseeHtgedvavfAygpkae......................lvrGvqeqteiakvlaaa
Metalloenzyme Metalloenzyme superfamily 313-391 1.8e-06 17.7 Pfam-A 121-196 (252) alignment 
Range on Protein: 313-391
Range on HMM: 121-196/252.0
TKPSLQEMTTKALNLISQNNENgfFLMVEGSKIDVAAHINDAPTQIWETDAFDQTFNLVREWAEKDGNtIVIVTADHET
.. | .|.| |.|. . ... .  |..|   ..| ..| .|.  ..    |.|.  . . . .||... ..|.|||| .
pemsakeitdkllealekgkyd..fvvvnlantDmvGHtgdveakvkaieavDerlkelldavekedd.lliitADHgn