Gene pho2a in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP2C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP077_AA protein Get Run
DdisP077_AA_4-292 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP2C_pd Subfamily PPP2C 5-293 2e-185 607.7 In-house 2-290 (290) alignment 
Range on Protein: 5-293
Range on HMM: 2-290/290.0
QDVDKYISILKECKPLSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRY
.|.||.|. |||||.|.||||..|||||.||||||||||.|.||||||||.|||||||.|||||||..|||||||.|||||||.||||||||||||||||
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

KDRVTILRGNHESRQITQVYGFYDECLRKYGNPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDLLWSDPDDRL
|.|.||||||||||||||||||||||||||||.||||.|||||||||||||...|.|||||||||||||||.|..|||.|||||||..||||||||||| 
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

GFGYSPRGAGYTFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDPAPRRG
|.|.|||||||||||||||.||..|||||.|||||||||||||.||.||||||||||||||||| |||.|.|.|.|..|||||||||||
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprrg
subfamily_PPP4C_pd Subfamily PPP4C 5-290 2.3e-148 486.1 In-house 1-286 (288) alignment 
Range on Protein: 5-290
Range on HMM: 1-286/288.0
QDVDKYISILKECKPLSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRY
.|.|. |  |..|. ..|.||..||.|||||| .||||| | .||||||||||||.||.||||.||..|.|||||.||.||||||||||  ||.||||||
sdldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvry

KDRVTILRGNHESRQITQVYGFYDECLRKYGNPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDLLWSDPDDRL
 ||.|..||||||||||||||||||||||||. |||.. |..||||.|.|.|....||.||||||||.|||.|  .|| |||||||..||||||||.|  
pdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae

GFGYSPRGAGYTFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDPAP
|.. ||||||| ||.|..||||..|...|..||||||||||..  ...|.|..|||||||||||.|||.|.||.... |  |. |.
gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaa
subfamily_PPP6C_pd Subfamily PPP6C 6-289 7.6e-137 448.2 In-house 1-284 (290) alignment 
Range on Protein: 6-289
Range on HMM: 1-284/290.0
DVDKYISILKECKPLSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYK
..||.|.. |.|| |.|.... ||..  ..|..|||||||..||||||||||||.||.|||. ||. |||.|.|.||.||||.||.||.|.|..||..| 
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

DRVTILRGNHESRQITQVYGFYDECLRKYGNPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDLLWSDPDDRLG
||.|.|||||||||||||||||||||.|||| |.|| .|..|| |...|.|..||.|.|||||| . |||.|. ..| ||.||.||.|||.||||.|   
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

FGYSPRGAGYTFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDPA
.  ||||||| ||. ....|.|.| | |..||||||.||...  |...||..|||||||||||.|.|...... ....  |.  
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkav
subfamily_PPG1_pd Subfamily PPG1 8-291 2.4e-130 427.2 In-house 2-298 (300) alignment 
Range on Protein: 8-291
Range on HMM: 2-298/300.0
DKYISILKECKPLSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDR
|. .  |. .. | |. |..|..| .|.| |||||. .|.|||| ||.||||.|..|.|||||..|||||||.|||||||.|||||..||..||.||  |
decleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsr

VTILRGNHESRQITQVYGFYDECLRKY-GNPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDLLWSDPD-----
.|.||||||||||||||||| |||||| ||..||| .|..|||| |.|.|.....|.|||||||. ..| |  ||| .|||.|||..|||||||.     
itllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnp

-----DRLG--FGYSPRGAGYTFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDPAPR
     || |  |  |.|||||..|||. |.| .|| .  . |||||..|||.   |. . |..||||||||||| |.|.|. || .. |  .. ||.
tldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeape
0045823 Metallo-dependent phosphatases 5-291 2.3e-121 398.6 In-house 28-326 (473) alignment 
Range on Protein: 5-291
Range on HMM: 28-326/473.0
QDVDKYISILKECKPLSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRY
 |.|..|..||... |.|.... |...|.|||.||.|....  ...|.||||||..||..|... |  |.....|.||.|||| .|.|.. || |||..|
ldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkiky

KDRVTILRGNHESRQITQVYGFYDECLRKYgNPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDLLWSDPDDRL
 ..|..||||||.|.....|||.||.|.|| . .... | .....|||.|.|...... ||||||....|| |....|..|.|..|...|||||||..  
pgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPwedd

G--------FGYSPRGAGYTFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQN------VVTIFSAPNYCYRCGNLAAIMEIDEKMkHTFLQFDPAP
|        || |||||||.||.|. |.| ..|||.|. |.|. |.|||....| .      ..|.|||||||.|.|||||...|||..  .| ||||.|
gdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsp

R
 
h
PPP_3 20-286 2e-118 387.3 In-house 2-269 (271) alignment 
Range on Protein: 20-286
Range on HMM: 2-269/271.0
LSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHESRQ
|||.|...|..|..|||.||||.. .. |||||||||||..||.||||.||..|.|.|||.||||||| .|.|...||.|||..|...|..|||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECLRKYGNPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDL-LWSDPDDRLGFGYSPRGAGYTFG
|..||||..|.|.|.|. .|.| ....|..|||.|||...|...||||||||..||.|..|.| .|||.||...|| |.|||... |.. |.||||..||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

KDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQF
.|..|.|...| |.|..|||.|..|||. .||..|||.|||||||.|..|..||....|.....| |.
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
PPP_1 21-274 1.5e-114 374.7 In-house 2-263 (264) alignment 
Range on Protein: 21-274
Range on HMM: 2-263/264.0
SESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHESRQI
.|.|...|..|..|.|.||.|.. |. ..||||||||||.||..|||.||..|.|||||.||||||| .|||...||.|||..|......|||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECLRKYGNPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDLL--------WSDPDDRLGFGYSPRG
|.||||..|.|.|... ...|..||.||.|||.|||.......||||||..|.||.|....| .|||.||..||||        ..|.... ..  |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGYTFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIME
|||.||||..|.|...|.|.|..|||....|||.......|||||||.||.....|..|...
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
0049330 Metallo-dependent phosphatases 5-292 2.6e-113 371.1 In-house 15-302 (309) alignment 
Range on Protein: 5-292
Range on HMM: 15-302/309.0
QDVDKYISILKECKPLSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRY
...|..|..|. .| |||.|.. |..||.||| .|.|....  ...|.||||||..||..|... |  |.....|.||.|||| .|.|...|| |||..|
slldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalklly

KDRVTILRGNHESRQITQVYGFYDECLRKYGnPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDLLWSDPD-DR
 |.|..||||||.|.....|||.||.||||| ...|. |.|....|||.|.|.....| ||||||.. .||.|..|.|..|.|..| .||||||||. .|
pdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpir

LGFGYSPRGAGYTFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDPAPRR
 ||. .|||.|..|| .. |.| . |||.|. |.|..|..|| ...|....|.|||||||.|.|||.|..||||.....||.|.|.|. 
egfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
PP2Ac_SM00156 21-289 4.4e-110 360.0 In-house 2-270 (271) alignment 
Range on Protein: 21-289
Range on HMM: 2-270/271.0
SESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHESRQI
|..||. |.|...|||..|.|.  |  ||||.||||||..||..|.. .| .|...|.|.||||||| .|.|...||.|||..| ..|..|||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECLRKYgNPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDLLWSDP-DDRLGFGYSPRGAGYTFGK
...|||..|. ||| . .... |...|..|||.||......|.||||||.. .||.|..|.||.| |.|| ..||||||| ..  ||  | ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDPA
|. ..| ..| | |. |||..|.|||....|...||||||||||....|.||........|... |....
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
0053225 Metallo-dependent phosphatases 6-290 2.3e-109 358.2 In-house 8-292 (293) alignment 
Range on Protein: 6-290
Range on HMM: 8-292/293.0
DVDKYISILKECKPLSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYK
..|..|..|. .| |||.|.. |...|.|||.||.|..... ...|.|||||...||..|... | .|.....|.||.|||| .|.|...|| |||..|.
lldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllyp

DRVTILRGNHESRQITQVYGFYDECLRKYGNPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDLLWSDPDDRLG
|.|..||||||.......|||.||.|||||. ..|. ..|....|||.|||...... ||||||....||.|....|....|.||...||||||||.. |
dnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsg

FGYSPRGAGYTFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDPAP
.. |.||.|..|| .. ..| ..|||.|. |.||.|..|| ...|...||.||||||..|.|||.|....||... .| .|.| .
wlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPP1C_pd Subfamily PPP1C 19-286 3e-106 347.7 In-house 9-276 (282) alignment 
Range on Protein: 19-286
Range on HMM: 9-276/282.0
PLSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHESR
 |.|.|.. |..|||||| ... .  .. ||...||||||..||. ||...|  |..||||.|||||||  |.||..||.|.|..|.... .||||||| 
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesa

QITQVYGFYDECLRKYGNPnVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDLLWSDPDD-RLGFGYSPRGAGYTF
.|...||||||| |.|..  .|| ||| |..|||.||......|.||||||... |..|... |  |||..| .|||||||||. .||.. . ||  .||
sinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftf

GKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQF
|||. |.| ..| | |. ||||.| .||..  ....||.||||||| . .| .|....||... .|  .
gkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqil
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 15-290 2e-97 318.8 In-house 19-295 (298) alignment 
Range on Protein: 15-290
Range on HMM: 19-295/298.0
KECKPLSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGN
| .| ..|..|  |.|.|..|..| . .  |  |..||||||||. ||. ||. .|  ||.||||.||||||| ...|...||.| ||.|.... .||||
kltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGn

HESRQITQVYGFYDECLRKYGNPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDLLWSDPDD-RLGFGYSPRGA
||  .| .|||||.|| |.| . .... | |.|. ||||||| ....|.|||||. . .||.. .| | .. ..|    ||||.||..   |.  . ||.
heceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrGv

GYTFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDPAP
...||.|  ... ..  . ||.||||.| .||..  ....|||||||.|| .  | ||.|..|||.. .|  . |. 
svvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
subfamily_PPP3C_pd Subfamily PPP3C 19-279 3e-88 289.6 In-house 40-313 (452) alignment 
Range on Protein: 19-279
Range on HMM: 40-313/452.0
PLSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHESR
 |.|...  . |.| ..|.||...  |  |.||.|||||||.||..||..||.  .|.|||.||||||| .|.|.|  | |||. |.... .||||||.|
rleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecr

QITQVYGFYDECLRKYGNpNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDLLWSDPDDRLGFGY--------SP
 .|. . | .||  ||.. .|.. ... || |||.||...| .|.|||||| | .|| |..||| .|.|. |..|||||||| .. |           |.
hlteyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsv

RGAGYTFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHD------QNVVTIFSAPNYCYRCGNLAAIMEIDEKM
||  | ..   . .| ..| |  . |||.   .||.  ..        ..|.||||||.    | ||....... 
rGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennv
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 18-292 6.1e-88 287.9 In-house 22-297 (299) alignment 
Range on Protein: 18-292
Range on HMM: 22-297/299.0
KPLSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHES
| . | |.. ||. |.... ... .  |  |. ||||||||. ||. .|.. |  ||.|.||.|||||||   .|..|||.. |..|..|  .|||||| 
ksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhec

RQITQVYGFYDECLRKYGNPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDLLWSDPDDRL-GFGYSPRGAGYT
  | .|||||.|| ..|    .| .| | |...||| || ....|.|||||| ..||| . .| | |. |      ||||.|||. . ..    ||  | 
painrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyv

FGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDPAPRR
||.|. ..  .. .. |||||||.| .||..  ....||||||| || .  | ||||..||..  ||  . |.|..
fgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpks
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 20-288 9.8e-88 287.3 In-house 8-282 (284) alignment 
Range on Protein: 20-288
Range on HMM: 8-282/284.0
LSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNC------PDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRG
|.| |. .|| .|||.. ||.  . ...||...||||||| ||. |... |         ...|||.||||||| .|.| .||| |.|... |.|..|||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHESRQITQVYGFYDECLRKYGNpNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDLLWSDPDDRL-GFGYSPRG
||||| . . |||| || ..| . .... |   |  .||.|.......|.|||.|  .  |. ...|.|  ..|  | ..|| |.||. .. |.  ||||
nhesrpvnmqygfyleckkryse.alyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprg

AGYTFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDP
|| .||..  ..|...  | || ||||.||.||..  |...||||||| || .  |.||....||..  .|  . |
agkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_PPP5C_pd Subfamily PPP5C 8-288 3.6e-84 275.5 In-house 22-308 (322) alignment 
Range on Protein: 8-288
Range on HMM: 22-308/322.0
DKYISILKECKPLSESEVRDLCEKAREILSKESNVQPVRCP----VTVCGDIHGQFHDLMELFKIGGNC-PDTNYLFMGDYVDRGFYSVETVTLLVALKV
.. .. .|. | | .  .  .  .|.|.|.|.. .  .. .    .||||||||||.||...|.. |   ..  ||| ||.|||| .|||.. .|...|.
kellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkl

RYKDRVTILRGNHESRQITQVYGFYDECLRKYGNpNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSI-DTLDHIENLDRVQEVPHEGAMCDLLWSDPD
 | ... . |||||| .. ..||| .|.  || . .| .|||..|..|||. .|...|. .||||  .   |||.. ..|| .. |.||....||||||.
lyPnhfflsrGnhesdnmnklyGfegevkakyte.kvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpq

DRLGFGYSPRGAGYTFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEI-DEKMKHTFLQFDP
.. | . | || | .|| |....| ..|.|.|. |.|.. .|||.  || ...|.||||||| . ||..|.... ....| .| .|. 
eanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfea
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 17-289 8.9e-83 270.6 In-house 5-275 (280) alignment 
Range on Protein: 17-289
Range on HMM: 5-275/280.0
CkpLSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHE
|  . | ..  . || ..||. .. .  | .||.||||.|||. ||. ||.  .  ||.||||.||||||| . .| . ||.| |||| ..  |||||||
c..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhe

SRQITQVYGFYDECLRKYGNpNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDLLWSDPD-DRLGFGYSPRGAGY
  .| . |||.||. |.| . .... | .|.| |||.||.  ...|.|||||. . .||.. .| |  . ..|    ||||.||. .  |.. ..||. .
visinrkygfkdevkrrysl.alynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsv

TFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDPA
 ||...  .. .   . |.|| ||.| .||..  |...||.||||.|.    | ||.. .||... .|  . ||
ifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 21-291 1.2e-81 267.0 In-house 9-279 (281) alignment 
Range on Protein: 21-291
Range on HMM: 9-279/281.0
SESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHESRQI
.. |. ..  ... |.|.|...  .  |..| ||.|.||.|| .||.. |  |.. ..|.|||||||  |.|.. || .||.||.||. .||||||  ..
tkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasv

TQVYGFYDECLRKYGNpNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDLLWSDPDDR-LGFGYSPRGAGYTFGK
 ..|||| ||  |||  ..| ||   |. ||..|||...| |.|||||| . .||.. |  .  . .. | . ||||.|||..  ..  | ||...||||
nkiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGk

DISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDPAPR
.. ..   . .. |. ||||.|..||.    ....|.||.||||    | ||.. .||... ..... ||. 
nvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpase
PPP_2 49-240 5.7e-80 260.7 In-house 1-197 (198) alignment 
Range on Protein: 49-240
Range on HMM: 1-197/198.0
VTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHESRQITQVYGFYDECLRKYGNPNVWKLFTDLFD
||||||.|||..||..||| |...|...|||.||||||| .|.|...||.|||..|...|..|||||||.....||||..|.|.|.|. .|.| ....|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDL-----LWSDPDDRLGFGYSPRGAGYTFGKDISEQFNHNNGLTLVARAHQL
.|||.|||...|...|||||..|..||.|.. .| .|.|.||...||     |....... ..  | ||||..||.|..|.. ..| |.|. |||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 17-286 9.7e-78 254.4 In-house 20-292 (297) alignment 
Range on Protein: 17-286
Range on HMM: 20-292/297.0
CKPLSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHE
.| ..|  |  | . | ... .. ..  | .|. ||||||||| ||. ||. ||  | .||||.||||||| .|.||. ||.| ||..   . .||||||
skviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhe

SRQITQVYGFYDECLRKYGNPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSP---SIDTLDHIENLDRVQEVpHEGAMCDLLWSDPDDRL-GFGYSPRG
   . .|||||.|| ..|    ..  | |.|..|||| || ....|.||||||      ||| . ...| .|  .|. ..||||.||   | ||    ||
cefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqrg

AGYTFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQF
||  ||.|   .   .  | ||.||||.| .||..   ...||||||| || .  | ||.|  |||.. .|  .
agcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeil
subfamily_PPZ_pd Subfamily PPZ 20-288 1.1e-77 254.5 In-house 25-293 (300) alignment 
Range on Protein: 20-288
Range on HMM: 25-293/300.0
LSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHESRQ
| .||. ..| ||||..  . ..  .  .| . ||.|||. ||. ||   |  | .||||.|||||||  |.||. ||.. |..| . . .||||||  .
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecan

ITQVYGFYDECLRKyGNPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDLLWSDPDDR-LGFGYSPRGAGYTFG
.|.|||||||| |.  | ..|| | | |. |||.|..  ..||.|||||| ....| |  . |  .||  | . ||||||| |    .    ||  | . 
vtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycyn

KDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDP
|   ..|  . |. ||.||| .| .||..  |...||.|||||||    |  |.| . | .  .|  .||
kvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
PPP_4 49-240 3.1e-76 248.8 In-house 1-196 (197) alignment 
Range on Protein: 49-240
Range on HMM: 1-196/197.0
VTVCGDIHGQFHDL-MELFKIGGNCP-DTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHESRQITQVYGFYDECLRKyGNPNVWKLFTDL
|||.||||||..|| ..|.|.||. . ...|.|.||||||| .|.|...||.|||..|...|..|||||||......|||..|.|.|  . ...| ..|.
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVP-HEGAMCDL-LWSDPD-DRLGFGYSPRGAGYTFGKDISEQFNHNNGLTLVARAHQL
||.|||.|||...|...|||||.....||.||...| .|.| .|....|| |||||  .  |.  | ||||..||.|. |.| ..|.| |. |.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 75-289 1.6e-75 247.2 In-house 101-315 (317) alignment 
Range on Protein: 75-289
Range on HMM: 101-315/317.0
TNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHESRQITQVYGFYDECLRKYGNpNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTL
 .|||.||||||| .|.| |.||.|||..| |.|..|||||||| . . |||| |. ..| . .... |   |  |||.|.......|.|||.| ..  |
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysa.alyeafqlafnvlplcavvnkkilcmhGGiseelldl

DHIENLDRVQEVPHEGAMCDLLWSDPDDR-LGFGYSPRGAGYTFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIM
. ...|.|  ..|  | ..|| |.||| .  |.  |.||||  ||..  ..|...  | || ||||.|..||..  |...|||||||.|| .  |.||..
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

EIDEKMKHTFLQFDPA
..|.|.| ..  . | 
svdkklkisinvlrpe
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 20-288 4.1e-75 245.3 In-house 10-281 (287) alignment 
Range on Protein: 20-288
Range on HMM: 10-281/287.0
LSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHESRQ
.|.... .. ||..|||   . .  |. |.|..||||||..||. .|.  |. |...|||.|||||||  |.| . || .||..|  .| .|||||| ..
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

ITQVYGFYDECLRKYGnPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRV--QEVPHEGAMCDLLWSDPDD-RLGFGYS-PRGAGY
| ..|||..|  ||..  ...| | |.|..||| | ......|.|||.|| ...|| .. | .   .   .|| . ||||.||.    .|     |.   
inklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisv

TFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDP
 |||   ... .. .. |. |||... |||..  |...||.|||| |. .  ||.|.. ... .. .| .. |
vfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp
PPP_5_Dcr2 49-240 1.9e-74 243.0 In-house 1-198 (199) alignment 
Range on Protein: 49-240
Range on HMM: 1-198/199.0
VTVCGDIHGQFHDL-MELFKIGGNCP-DTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHESRQITQVYGFYDECLRKYGNPNVWKLFTDL
||||||.|||..|| ..||| ||. . ...|.|.||||||| .|.|...||.|||..|...|..||||||..|....|||..|.|.||.. ...| ..|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVP-HEGAMCDL-LWSDPD-DRLG-FGYSPRGAGYTFGKDISEQFNHNNGLTLVARAHQL
||.|||.|||...|...||||||.|......|...| .|.| ..| ..|| |||||  .  | .  | ||||..||.|. |.| ..|.| |. |.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 20-290 3e-70 229.9 In-house 6-276 (280) alignment 
Range on Protein: 20-290
Range on HMM: 6-276/280.0
LSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHESRQ
..  |.  .      |. .|||.    .|. | |||| |..|.  || . |  |. . .|.|||||||   .| . ||..||.||.||. .||||||.  
mtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetps

ITQVYGFYDECLRKYGNPnVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDLLWSDPDDR-LGFGYSPRGAGYTFG
. ..|||| ||  |||   .|  |   |. .|...|| ..|.|.|||||| .  || | |. |  |    | . ||||||| ..  |. .| ||  | ||
vnkiygfyvecqykygvg.lwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfg

KDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDPAP
| . ||  ..  . |. ||||.| .||.    . ..|.|| |||| .  | ||.. .. ... .| |. | |
kgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlippp
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 23-288 4.4e-69 226.0 In-house 6-273 (284) alignment 
Range on Protein: 23-288
Range on HMM: 6-273/284.0
SEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHESRQITQ
 .|  |  .| .|. |.  .  |  |. .|||||||| ||. ||   |    .||||.||||||| . .||. ||.| || . ... .||||||   | .
edvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

VYGFYDECLRKYGNPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAM-CDLLWSDPDD-RLGFGYSPRGAGYTFGKD
.||||.|| |.| .| |.. |  .|  .|||||. ....|.|||.|  .. . ..  . |  . |   ..  |.||||| . . |.    ||  | || |
iygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsd

ISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDP
   ..     . || ||||.| .||..  .. .||||||| || .  | ||.| .....  .|. . |
alrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrp
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 20-288 3.5e-68 222.7 In-house 16-288 (290) alignment 
Range on Protein: 20-288
Range on HMM: 16-288/290.0
LSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHESRQ
.|.... .. ||..|||     .  |  |... ||||||. .|.. |.  |  |. ..||.|||||||  |.|   ||  .|.||  .| .|||||| |.
fsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrk

ITQVYGFYDECLRKYGnPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLD--RVQEVPHEGAMCDLLWSDPDD--RLGFGY-SPRGAG
. ..|||..|  || |  ..|| . |.|. |.| | ......|.|||.|. |.. . .. |   ||.   .|| . ||||.||.      . .   |.  
vnrlygfkeelarkrg.srlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqrais

YTFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDP
  |||.  ... .. .| |. |||..  ||.|.  |...||.|||| |. .  || ||... | .. ..  . |
vvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkp
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 23-290 2.1e-65 213.9 In-house 23-293 (307) alignment 
Range on Protein: 23-290
Range on HMM: 23-293/307.0
SEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHESRQITQ
 |. ..  .|. |.| |  .  .  |. | ||.|||| ||...| . |  |.| |.| |||||||. |.|.. ||.. |. | . . .||||||  .. .
eefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnk

VYGFYDECLRK---YGNpNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDLLWSDPDDR-LGFGYSPRGAGYTFG
 ||||.||.      |. ..| ||   |. ||..|||  ...|.||||||..  || . |  .    |  | . |.||.|||   . .  | ||.|.|||
kygfyeecvtsipkcge.eiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfg

KDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDPAP
 .. ..  .  |. |. ||||....||     ....|||||| ||    |  ... .|| .    . | |. 
tnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpes
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 76-291 2.5e-58 190.8 In-house 121-336 (339) alignment 
Range on Protein: 76-291
Range on HMM: 121-336/339.0
NYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHESRQITQVYGFYDECLRKYgNPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLD
 |||.||||||| .|.| | || |||. | ||. .|||||||| .   |||| |   .| . .... | ..|. .|. |.|.| ..|.|||.|  . ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

HIENLDRVQEVPHEGAMCDLLWSDPDD-RLGFGYSPRGAGYTFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIME
..  . |  |.|  | . || |.|||    |.  | ||| . ||      | ..  | .| | ||.| .||..   . .|||||||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

IDEKMKHTFLQFDPAPR
||.|.| .   | |  |
idkklkisinvfrpesr
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 20-282 7.2e-57 185.8 In-house 6-293 (302) alignment 
Range on Protein: 20-282
Range on HMM: 6-293/302.0
LSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFK-----------IGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRV
.|.||.  |.|.  | |.||...  .  |||. |||||||.||. ...           .        ..|.|||||||  |.| ..|. |||| |. . 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TILRGNHESRQITQVYGFYDECLRKYGNPN---VWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDR-VQEVPHEGAMCDLLWSDPDDRL
 .||||||.. |   ||| .|   ..|. .   .|. | . | ..||.||. ....|.|||.|| ...|..|....| ..|| ..    |||..|| |  
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GFGYSPRGAGY----------TFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHT
.    ..   |          .| .   ... .. .| |. |||| . ||...  |....||||||.|     |  |....| . | .
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngkls
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 20-282 1.2e-56 185.2 In-house 7-294 (302) alignment 
Range on Protein: 20-282
Range on HMM: 7-294/302.0
LSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFK-----------IGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRV
.|.||.  |.|.  | |.||...  .  |||. |||||||.||. ...           .        ..|.|||||||  |.| ..|. |||| |. . 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TILRGNHESRQITQVYGFYDECLRKYGNPN---VWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDR-VQEVPHEGAMCDLLWSDPDDRL
 .||||||.. |   ||| .|   ..|. .   .|. | . | ..||.||. ....|.|||.|| ...|..|....| ..|| ..    |||..|| |  
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GFGYSPRGAGY----------TFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHT
.    ..   |          .| .   ... .. .| |. |||| . ||...  |....||||||.|     |  |....| . | .
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngkls
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 46-288 2.1e-54 177.9 In-house 6-255 (263) alignment 
Range on Protein: 46-288
Range on HMM: 6-255/263.0
RCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHESRQITQVYGFYDECLRKYGNPN----VWK
..|. .||| |||. ||. .|.  | .  |.|||.||||||| .|.| . ||..||.    .. .|||||| . | . |||. |  ...   .    |..
qapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvyn

LFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPH-EGAMCDLLWSDPD-DRLGFGYS-PRGAGYTFGKDISEQFNHNNGLTLVARAH
 | ..| |.|| |.. ....|.|||.|| . .|| |  .    |  .     |||||.||. |  ||     |     |||   ... .   . |. |||
hfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivrah

QLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDP
|.|  || .  |. ..|.|||  |     | ||.. ... .. .|.|. |
qvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp
subfamily_PPPLV_pd Subfamily PPPLV 27-279 1.4e-53 175.1 In-house 4-279 (290) alignment 
Range on Protein: 27-279
Range on HMM: 4-279/290.0
DLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLM----ELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHESRQITQ
 ||..| .|| .| .. ... |. | ||.||...||.     |...| .   ...||.||||||| .||| .. |.|||| |  .| .|||||| . ...
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

VYGFYDECLRKYGNP--NVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQE---VPHEGA--MCDLLWSDPDDR------------
 . .. |.  |.|.   .||. |.. ||.|||.| |...||| |.|.  .| |  .|  .. . |    . .||    |.|||||..             
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

LGFGY-SPRGAGYTFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRcGNLAAIMEIDEKM
 ||   . || |. |..|  |.| ..|.|  | |||.   .|..  ..  ..|.||. .||    | ||.. .|.| 
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvdkkk
Metallophos Calcineurin-like phosphoesterase 48-240 1.7e-44 145.5 Pfam-A 2-198 (200) alignment 
Range on Protein: 48-240
Range on HMM: 2-198/200.0
PVTVCGDIHGQFHDL----MELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLL--VALKVRYKDRVTILRGNHESRQITQVYGFYDECL----------
...|.||.||...||    ..|.||..... ...||.||.|||| .| ||  ||   .||......|  |||||||......|||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGNPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIenldrvqevphegamcdllwsdpddrlgfgy
                       .........  . . |..||| ||....... ||.||.| .. | |                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGYTFGKDISEQFNHNNGLTLVARAHQL
    ... ||.|  | .  ..|..|| |.|. 
....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 5-184 4.2e-38 124.1 In-house 18-203 (383) alignment 
Range on Protein: 5-184
Range on HMM: 18-203/383.0
QDVDKYISILKECKPLSESEVRDLCEKAREILSKESNVQPVRC----PVTVCGDIHGQFHDLME-LFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVA
..|.| |  .|| | |    |  .  .|...| .  |.. |       ||||||.||.. ||.  |.| |   .. .|.| ||.||||  ||| . .|.|
deveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillilla

LKVRYKDRVTILRGNHESRQITQVYGFYDECLRKY--GNPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDtLDHIENLDRVQ
| . |   | . |||||   .   |||  |   ||   . .. .|. |.| .|||..||..... .|||.| . | |. .....| .
lllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktd.lelldkiersk
subfamily_PPP7C_pd Subfamily PPP7C 192-289 6.2e-22 70.8 In-house 237-335 (383) alignment 
Range on Protein: 192-289
Range on HMM: 237-335/383.0
MCDLLWSDPDDRLGF-GYSPRGAGYTFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDPA
. |.|||||  . |    . ||.|  || |..... .. .|.|. |.|.  .|||...||..|.||||| ||     |  | . . ....  ..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 20-70 6.4e-14 44.8 In-house 9-59 (317) alignment 
Range on Protein: 20-70
Range on HMM: 9-59/317.0
LSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGG
..|.|. .|| .|||.. ||     ...|||..|||||||.||. |... |
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_YNL217W_pd Subfamily YNL217W 50-122 6.6e-09 28.6 In-house 13-81 (235) alignment 
Range on Protein: 50-122
Range on HMM: 13-81/235.0
TVCGDIHGQFHDLMELFK--IGGNCPDTNYLFMGDYVDRGFYSVETVTLLvalkvrYKDRVTILRGNHESRQITQ
 | ||.|| . .|.||..  |||  ..   ...|| ...|  |||.| ..       || |  ..||||   . .
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvlla
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 22-70 1.1e-08 27.6 In-house 13-61 (339) alignment 
Range on Protein: 22-70
Range on HMM: 13-61/339.0
ESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGG
 .|. .|| .|||..  |  .  . .|. | ||||||| ||. .. . |
aaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmng