Gene DDB_G0276253 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP086_AA protein Get Run
DdisP086_AA_310-506 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PFKFB_pd Subfamily PFKFB 312-507 1.2e-77 251.8 In-house 1-195 (198) alignment 
Range on Protein: 312-507
Range on HMM: 1-195/198.0
NLHLTPRPILLCRSGESEWEVLGRKGGDSELTAEGENFSHRLASWVDENSQNeEVTVWTSTFKRSIRTAQYIPHPKIHVKALDDLDRGEWQGLKREDILK
|.||.|| |.|.|.||||... || |||||||..|......||....|.. . |..||||..||.|.||... .|| ..||||.||.|...||. |.| .
nihlkpreiylvRhGeseknkkgriggdseLterGveyakklakfikeenlk.elrvwtselkrtiqTaellglpkeqwkaLdeldaGkcdgltyeeike

KMPEEFGAHSDDKLGYRIPRGECYLDVIQRLESVILELERTKNTSLIVSHPAPLRCLYGYITGEPIEKFPYINIPLNTVISLLPTAYGCEVKTYKL
|.|||| ....||. ||.||||.| |..||||.|||||||.... ||..| | ||.|..|.. . .|..||...||.|||.| |.||||.|...||
kfpeefkerkkdkyryryprgEsyedlvqRlepvileLereqenvliiaHqavlrvllaylldksaeelpylkvplhtvikltpvaYgckvellkl
6PF2K 6-phosphofructo-2-kinase 98-317 6.6e-71 228.3 Pfam-A 2-223 (223) alignment 
Range on Protein: 98-317
Range on HMM: 2-223/223.0
RQYVYTGFESDKIVVVMVGLPASGKTYISRKVRNLLNWMGVPAKVFTVGDYRRLRLGAKQPAEFFDPGNIDASRVRLHMAVAAIDDMMAWLN-SGAQAGI
.| ... ... |.|.|.||||| ||||||.|.   |.|.||..||| ||.|||    |.. ||||.| | .| ..| ..| ||..|....||  ..| .|
dqstvknlknsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgkyrreavkalsdaeffrpdneealklreklalaalkdllkylneeegqvai

FDATNLTTERRQLILSRCAREGiEKVIFVESFMTDKKKIETNMIENWKSSPDYEHHSQAEAVNHFRERLSYYEKEYVSID--KSDQLQFIKLFDVGKKII
||||| | |||.|||... ...  ||.|.||. .|.. |..|. |   |||||. ....||.. | .||. |||.| ..|  .  .|..||..||||...
fDAtNttrerRklilefveenn.lkvlflesvcsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyeplddeedeelsyIkvidvgkslv

ANNITGYLPSRIMFLLMNLHLTP
.||..||| |||.. |.|.||.|
vnnvqgylqsrivyyllNihlkp
0039931 Phosphoglycerate mutase-like 320-506 2.5e-44 143.5 In-house 2-186 (219) alignment 
Range on Protein: 320-506
Range on HMM: 2-186/219.0
ILLCRSGESEWEVLGRKGGDSELTAEGENFSHRLASWVDENsQNEEVTVWTSTFKRSIRTAQYIPHPKIHVKALDDLDRGEWQGLKREDILKKMPEEFGA
..|.| ||.|| | ||  |||.||..|.  ...|. .  .. . .   |..|...|.|.||..|. | .. ..| ..| | ..||  |.| .|.|||. |
lyLvRHGetewnvegrlqgdspLterGreqaralgerlkdl.glpfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltleeiaekypeelaa

HSDDKLGYRIPRGECYLDVIQRLESVILELERtKNTSLIVSHPAPLRCLYGYITGEPIEKFPYINIPLNTVISLLPTAYGCEVKTYK
.  |.. ||.|.||.. ||..|..... ||..  .. |.||| ...|.|. |..| ..| ....|.|  .|. | ....|. .... 
wlrdpydyrppggEsladvvaRvlpaleella.genvlvVsHggvirallayllglsleeilrlnlpngsvtvlelddggwvlvlln
0035570 Phosphoglycerate mutase-like 320-502 3.8e-43 139.8 In-house 2-182 (219) alignment 
Range on Protein: 320-502
Range on HMM: 2-182/219.0
ILLCRSGESEWEVLGRKGGDSELTAEGENFSHRLASWVDENsQNEEVTVWTSTFKRSIRTAQYIPHPKIHVKALDDLDRGEWQGLKREDILKKMPEEFGA
..|.| ||.|| . ||  ||..||..|.  ...|. .  .. . .   |..|...|.|.||..|  | .  ..| ..| |...|| ...| .|.|||. |
lyLvRHGetewnlegrlqgdvpLterGreqaralgealadl.gipfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltldeiaekypeelaa

HSDDKLGYRIPRGECYLDVIQRLESVILELeRTKNTSLIVSHPAPLRCLYGYITGEPIEKFPYINIPLNTVISLLPTAYGCEV
.  |.. ||.|.||.. ||..|..... || .  .. |.||| ...|.|. |..| |.| ....|.|  .|. | ....|. .
wlrdpydyrppggEsladvvaRvlpaleel.edgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggggkw
0053607 Phosphoglycerate mutase-like 318-505 8.4e-41 131.9 In-house 2-187 (191) alignment 
Range on Protein: 318-505
Range on HMM: 2-187/191.0
RPILLCRSGESEWEVLGRKGGDSELTAEGENFSHRLASWVDENsQNEEVTVWTSTFKRSIRTAQYIPHPKIHVKALDDLDRGEWQGLKREDILKKMPEEF
. ..|.| ||.|| . ||  ||..||..|.   ..|| .  |  . .   |..|...|...||..|  | .....| ..| |.|.|| .|.. .|.|||.
trlyLvRHGetewnaegrlqgdvpLtelGreqaralaellael.glkfdavysSpllRarqTaeiiglpvevdprlrEidfgdwegltleelaekypeel

GAHSDDKLGYRIPRGECYLDVIQRLESVILELERtKNTSLIVSHPAPLRCLYGYITGEPIEKFPYINIPLNTVISLLPTAYGCEVKTY
 |. .|.| ||.|.||.. ||..|..... || .  .. |.|.| ...|.|. |..| |.| ....|.|  .|. | .. .|. ....
aawlrdpldyrppggEsladvaaRvlpaleella.ggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggwvlvll
0037864 Phosphoglycerate mutase-like 311-505 1.9e-39 127.6 In-house 1-207 (211) alignment 
Range on Protein: 311-505
Range on HMM: 1-207/211.0
MNLHLTPRPILLCRSGESEWEVLGRKGG--DSELTAEGENFSHRLASWVDENsQNEEVTVWTSTFKRSIRTAQYI----P---HPKIHVKALDDLDRGEW
|.|.|... ..|.| ||.|| . ||  |  |..||..|.   ..|. .. .. . .   |..|...|.|.||..|    .    | .. ..| ..| |..
MslnllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadl.glpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgal

QGLKREDILKKMPEEFGAHSDDKLGYRIPRGECYLDVIQRLESVILELERTK----NTSLIVSHPAPLRCLYGYITGEPIEKFPYINIPLNTVISLLPTA
.||  |.| .|.|||. |.  |.. .|.| ||.. ||..|..... || ..     .. |.||| ..||.|. |..| ..| ....|.| ..|. |  . 
egltleeiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsleellrlnlpngsvtvleldd

YGCEVKTY
.|. ....
ggwvlvsl
0043909 Phosphoglycerate mutase-like 318-504 2.9e-39 127.3 In-house 3-230 (249) alignment 
Range on Protein: 318-504
Range on HMM: 3-230/249.0
RPILLCRSGESEWEVLGRKGG--DSELTAEGENFSHRLASWVDENSQNEEVtVWTSTFKRSIRTAQYI----P---HPKIHVKALDDLDRGEWQGLKRED
. ..|.| ||.|| . ||  |  ||.||..|.   ..|. .. |.  . .. |..|..||.|.||..|    .    | .  ..| ..| |...||. ..
krlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfda.vysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkae

ILKKMPEEFGAHSD-----------------------------DKLGYRIPRGECYLDVIQRLESVILELERT----KNTSLIVSHPAPLRCLYGYITGE
|..|.|||. |.                               |.| .|.|.||.. ||..|..... || ..     .. |||.| . ||.|. |..| 
iaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllgl

PIEKFPYINIPLNTVISLLPTAYGCEVKT
..| ....|.|  ... | ....|..|..
sledilrlnlpngsitvlelddggkpvvv
0036777 Phosphoglycerate mutase-like 318-499 2.1e-38 124.7 In-house 3-221 (247) alignment 
Range on Protein: 318-499
Range on HMM: 3-221/247.0
RPILLCRSGESEWEVLGRKGG--DSELTAEGENFSHRLASWVDENsQNEEVTVWTSTFKRSIRTAQYI----P---HPKIHVKALDDLDRGEWQGLKRED
. ..|.| ||.|| . ||  |  |..||..|.   ..|. .. |. .     |..|...|.|.||..|    .    | .  ..| ..| |...||....
krlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkel.glpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkae

ILKKMPEEFGAHSDDKLGYRI-------------------------PRGECYLDVIQRLESVILELERT----KNTSLIVSHPAPLRCLYGYITGEPIEK
|..|.|||. |. .|.. ||.                         | ||.. ||..|..... || ..     .. |.||| ..||.|. |..| ..| 
iaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsled

FPYINIPLNTVISLLPTAYG
....|.|  ... |  ...|
ilrlnlpngsitvleldddg
0049178 Phosphoglycerate mutase-like 317-505 2.4e-38 124.5 In-house 3-226 (243) alignment 
Range on Protein: 317-505
Range on HMM: 3-226/243.0
PRPILLCRSGESEWEVLGRKGG--DSELTAEGENFSHRLASWVDENsQNEEVTVWTSTFKRSIRTAQYI----P---HPKIHVKALDDLDRGEWQGLKRE
.. ..|.| ||.|| . ||  |  ||.||..|.   ..|. .  |. .     |..|. || |.||..|    .    | .....| ..| |...|| ..
mtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellael.glkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltka

DILKKMPEEFGAHSDDKLGYRI-----------------------PRGECYLDVIQRLESVILELERT----KNTSLIVSHPAPLRCLYGYITGEPIEKF
.| .|.|||. |. .|.. .|.                       | ||.. ||..|..... || ..     .| |.|.| ...|.|. ...| |.| .
eiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllglpleel

PYINIPLNTVISLLPTAYGCEVKTY
...|.|  .|. |  . .|. ....
lrlnlpngsvtvlelddggwvlvsl
0051064 Phosphoglycerate mutase-like 317-503 2.4e-37 121.5 In-house 3-226 (241) alignment 
Range on Protein: 317-503
Range on HMM: 3-226/241.0
PRPILLCRSGESEWEVLGRKGG--DSELTAEGENFSHRLASWVDENsQNEEVTVWTSTFKRSIRTAQ----YIP---HPKIHVKALDDLDRGEWQGLKRE
.. ..|.| ||||| . ||  |  |..||..|.  ...|. .  .. .     |..|...|.|.||.    ...    | .. ..| ..| | ..|| .|
mkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladl.gikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltle

DILKKMPEEFGAHSDDKLGYRI-------------------------PRGECYLDVIQRLESVILELERT----KNTSLIVSHPAPLRCLYGYITGEPIE
.| .|.|||. |.  |.| .|.                         |.||.. ||..|..... || ..     .. |.||| ...|.|..|..| |.|
eiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllglple

KFPYINIPLNTVISLLPTAYGCEVK
 ....|.|  .|. |  ...|..|.
ellrlnlpngsvtvleldddgkrvv
0036887 Phosphoglycerate mutase-like 318-505 3.1e-37 120.5 In-house 2-195 (202) alignment 
Range on Protein: 318-505
Range on HMM: 2-195/202.0
RPILLCRSGESEWEVLGRKGG--DSELTAEGENFSHRLASWVDensQNEEVTVWTSTFKRSIRTAQYI----PHPKIHVKALDDLDRGEWQGLKREDILK
. ..|.| ||.|| | ||  |  |..||..|.   ..|. ..    .     |..|...|.|.||..|    ..| |. ..| ..| | ..||  |.| .
trlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla...glpfdavysSpllRaiqTaeiiaealglpvivdprlrEidfgalegltleeiae

KMPEEFGAHSDDKLGYRIPRGECYLDVIQRLESVILELERT--KNTSLIVSHPAPLRCLYGYITGEPIEKFPYIN-IPLNTVISLLPTAYGCEVKTY
|.|||. |.  |.. .|.|.||.. ||..|..... || ..   .. |.||| ..||.|. |..| ..| ..... .|  .|. |  ...|. ....
kypeelaawlrdpydfrppggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlelddggwvlvll
0048955 Phosphoglycerate mutase-like 320-499 2.8e-36 118.0 In-house 3-219 (240) alignment 
Range on Protein: 320-499
Range on HMM: 3-219/240.0
ILLCRSGESEWEVLGRKGG--DSELTAEGENFSHRLASWVDENsQNEEVTVWTSTFKRSIRTAQ----YIP---HPKIHVKALDDLDRGEWQGLKREDIL
..|.| ||||| . ||  |  |..||..|.  ...|. .  .. .     |..|...|.|.||.    ...    | ..  .| ..| | ..|| ...| 
lyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadl.gikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeia

KKMPEEFGAHSDDKLGYRI-------------------------PRGECYLDVIQRLESVILELER----TKNTSLIVSHPAPLRCLYGYITGEPIEKFP
.|.|||. ..  |.| .|.                         |.||.. ||..|..... || .    . .. |.||| ...|.|..|..| |.| ..
ekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglpleeil

YINIPLNTVISLLPTAYG
..|||   |. |  . ..
rlnipngsvtvlelddgl
0050036 Phosphoglycerate mutase-like 320-491 1.8e-32 104.3 In-house 3-163 (171) alignment 
Range on Protein: 320-491
Range on HMM: 3-163/171.0
ILLCRSGESEWEVLGRKGG--DSELTAEGENFSHRLASWVdensqnEEVTVWTSTFKRSIRTAQYIPHPKIHVKALDDLDRGEWQGLKREDILKKMPEef
..|.| ||.|| . ||  |  |..||..|.   ..|. .       .   |..|. .|...||..|  | |....| ..| |.|.||  ..| .|.||  
lyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell......pfdavysSpllRArqTaelillpvivdprLrErdfGawegltldeiaakype..

gaHSDDKLGYRIPRGECYLDVIQRLESVILELErtkNTSLIVSHPAPLRCLYGYITGEPIEKFPYINIPLNTVI
  .  |.| ...| ||.. ||..|. ... ||    .. |.|.| . .|.|. ...| ..| ......|  .|.
..wlldlldlappggEsladvlaRvlpaleell...gnvlvvaHggvirallalllglsleeilrlelpngsvl
His_Phos_1 Histidine phosphatase superfamily (branch 1) 320-468 2.1e-25 82.5 Pfam-A 2-158 (158) alignment 
Range on Protein: 320-468
Range on HMM: 2-158/158.0
ILLCRSGESEWEVLGRKGGDSE--LTAEGENFSHRLASWVDEnsQNEEVT-VWTSTFKRSIRTAQYIPH----PKIHVKALDDLDRGEWQGLKREDILKK
..|.| |||||.  ||  |.|.  ||..|..  ..|. . ..  ...... |.||..||.| ||...      | |  ..|  .| |||.||..|.. ..
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkr..adlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkee

MPEEFGAHSDDKLGYRIPRGECYLDVIQRLESVILELER---TKNTSLIVSHPAPLRCL
 |||. .  .||  .|.|.|| . ||..|..... || .   .... ||||| . ||.|
fpeeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
His_Phos_1 Histidine phosphatase superfamily (branch 1) 320-468 2.1e-25 82.5 In-house 2-158 (158) alignment 
Range on Protein: 320-468
Range on HMM: 2-158/158.0
ILLCRSGESEWEVLGRKGGDSE--LTAEGENFSHRLASWVDEnsQNEEVT-VWTSTFKRSIRTAQYIPH----PKIHVKALDDLDRGEWQGLKREDILKK
..|.| |||||.  ||  |.|.  ||..|..  ..|. . ..  ...... |.||..||.| ||...      | |  ..|  .| |||.||..|.. ..
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkr..adlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkee

MPEEFGAHSDDKLGYRIPRGECYLDVIQRLESVILELER---TKNTSLIVSHPAPLRCL
 |||. .  .||  .|.|.|| . ||..|..... || .   .... ||||| . ||.|
fpeeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
AAA_33 AAA domain 111-238 1.4e-09 28.5 Pfam-A 1-114 (143) alignment 
Range on Protein: 111-238
Range on HMM: 1-114/143.0
VVVMVGLPASGKTYISRKVRNLLNWMGVPAKVftvgdYRRlRLGA-KQPAEFfdpgniDASRvRLHMAVAAIDDMMAWLNSGAQAGIFDATNLTTERRQL
.|..||||.|||.. .... . | .  . . .     .|| || . .|. .       | .| .|. . ... .. ..  |  .. |.|||||. |.|. 
lvllvGlpGsGKstlaerllkklgyvrlsqdt.....lrr.rlfgtdqqslt......dytr.vlkrlyqilnklarkalsagrsvivdatnlsreerar

ILSRCAREGIEKVIFVesFMTDKKKIETN
..  . | | .  |..  . ....... .
fvklakrlgvpvrivy..levpeetlaeR
AAA_17 AAA domain 111-191 2.2e-06 19.1 Pfam-A 1-77 (121) alignment 
Range on Protein: 111-191
Range on HMM: 1-77/121.0
VVVMVGLPASGKTYISRKVRNLLNwmgvpAKVFTVGDYRRLRLGAKQPAEFFDPgnIDASRVRLHMAVAAI---DDMMAWLNSG
|.. .| |.|||....... . |.      .|.  .|..| .  .. ......   .||.. .|.  ....   .| . |. .|
viaitGppGsGKsTlakeLaerlg.....lpvlslddllreeglkelddgeres..kdadadllaaildglaakkdtlswvidg
subfamily_PGAM_pd Subfamily PGAM 320-415 5.5e-06 17.8 In-house 3-106 (248) alignment 
Range on Protein: 320-415
Range on HMM: 3-106/248.0
ILLCRSGESEWEVLGRKGG--DSELTAEGENFSHRLASWVDENSQNEeVTVWTSTFKRSIRTAQYIP----HPKIHVK---ALDDLDRGEWQGLKREDIL
..| | ||||.    .  |  | .|. .|..  ....  . ..  .    |.||. ||...|.. |     . || |.    | .   |...||......
lvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlef.divytSvlkRaqqTlevileeldqekiPvektwrLnErhyGaltglnkaeva

KKMPE
||  |
kkyGe