Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_PFKFB_pd | Subfamily PFKFB | 383-585 | 4.5e-86 | 279.4 | In-house | 1-195 (198) | alignment | ||
Range on Protein: 383-585
Range on HMM: 1-195/198.0
NLHLHPRPIWLTRQGESEFNAQNRIGGDSDLTERGDNYAHQLAVWISEwcskvraDGYDgEVVVWTSSLKRAIRTAQYISQPKVVMRALDEIDAGVCDGM
|.||.|| |.|.|.|||| |...||||||.|||||..||..|| .|.| . .. |. ||||.|||.|.||.... || ..||||.|||.|||.
nihlkpreiylvRhGeseknkkgriggdseLterGveyakklakfike.......enlk.elrvwtselkrtiqTaellglpkeqwkaLdeldaGkcdgl
TYEEIQEKMPDERAARDSDKLQYRYPRGESYEDVIQRLEPLLLELERTKSPVLIVSHQATLRCLYSYLKGRVKEECPFINIPLHTLIQLSPKAYGCEETT
|||||.||.|.| ..|..||..|||||||||||..|||||..|||||... |||..|||.||.|..||. . ||.|....||||.|.|.|.||||. ..
tyeeikekfpeefkerkkdkyryryprgEsyedlvqRlepvileLereqenvliiaHqavlrvllaylldksaeelpylkvplhtvikltpvaYgckvel
FKL
.||
lkl
|
|||||||||
6PF2K | 6-phosphofructo-2-kinase | 176-388 | 2.3e-80 | 259.2 | Pfam-A | 7-223 (223) | alignment | ||
Range on Protein: 176-388
Range on HMM: 7-223/223.0
TGLDKEKIVLVMVGLPARGKTYVARKICRMLNWMLVPAKVFNVGEYRRLRIGAGQPHDFFDPHNPEGIKARLHMAVAALDDMISWLH-NGGRVGIYDATN
. |...|.|.|.||||||||||...|..|.|.|. |..||||||.||| | . .||.|.|.|..|.| ..| |||.|....|. ..| |.|.||||
knlknsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgkyrreavkalsdaeffrpdneealklreklalaalkdllkylneeegqvaifDAtN
STNERRQLVEKRCTREKMTVVYVESICNDASVIEHNIKETKLLSPDYQGVDPSKAVQDFRDRINHYLKVYETVE---GEKTRYIKLFDVGKKIEVNNITG
.| |||.|. ........ |...||.|.| ..|..|||| || ||||.. ....|..|| |...| |.|| .. |. .|||..||||.. |||..|
ttrerRklilefveennlkvlflesvcsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyeplddeedeelsyIkvidvgkslvvnnvqg
YIPSRVVFFLMNLHLHP
|. ||.|..|.|.||.|
ylqsrivyyllNihlkp
|
|||||||||
0039931 | Phosphoglycerate mutase-like | 391-583 | 1.5e-50 | 163.9 | In-house | 2-185 (219) | alignment | ||
Range on Protein: 391-583
Range on HMM: 2-185/219.0
IWLTRQGESEFNAQNRIGGDSDLTERGDNYAHQLAVWISEWcsK--VradgydgeVVVWTSSLKRAIRTAQYISQPKVVMRALDEIDAGVCDGMTYEEIQ
..|.| ||.|.|...|. |||.||||| .|..|. ..... . . .|..| |.|||.||..| | ... .| |||.|...|.|.|||.
lyLvRHGetewnvegrlqgdspLterGreqaralgerlkdl..glpf........davysSpllRaiqTaeiiglpveidprLrEidfgdlegltleeia
EKMPDERAARDSDKLQYRYPRGESYEDVIQRLEPLLLELERtKSPVLIVSHQATLRCLYSYLKGRVKEECPFINIPLHTLIQLSPKAYGCEETTF
||.|.| ||. |.. ||.|.|||..||..|..|.| ||.. ..||.|||....|.|..|| | ||.. .|.| .... |.....|. ...
ekypeelaawlrdpydyrppggEsladvvaRvlpaleella.genvlvVsHggvirallayllglsleeilrlnlpngsvtvlelddggwvlvll
|
|||||||||
0035570 | Phosphoglycerate mutase-like | 391-577 | 6.7e-50 | 161.8 | In-house | 2-179 (219) | alignment | ||
Range on Protein: 391-577
Range on HMM: 2-179/219.0
IWLTRQGESEFNAQNRIGGDSDLTERGDNYAHQLAVWISEWcsKVRADgydgevVVWTSSLKRAIRTAQYISQPKVVMRALDEIDAGVCDGMTYEEIQEK
..|.| ||.|.|...|. ||..||||| .|..|. .... ... | .|..| |.|||.||..| | ... .| |||.|...|.|..||.||
lyLvRHGetewnlegrlqgdvpLterGreqaralgealadl..gipfd......avysSpllRaiqTaeiiglpveidprLrEidfgdlegltldeiaek
MPDERAARDSDKLQYRYPRGESYEDVIQRLEPLLLELeRTKSPVLIVSHQATLRCLYSYLKGRVKEECPFINIPLHTLIQLSPKAYG
.|.| ||. |.. ||.|.|||..||..|..|.| || . ..||.|||....|.|..|| | ||....|.| .... |.....|
ypeelaawlrdpydyrppggEsladvvaRvlpaleel.edgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggg
|
|||||||||
0053607 | Phosphoglycerate mutase-like | 389-578 | 2.4e-46 | 149.9 | In-house | 2-182 (191) | alignment | ||
Range on Protein: 389-578
Range on HMM: 2-182/191.0
RPIWLTRQGESEFNAQNRIGGDSDLTERGDNYAHQLAVWISEWcskvradgYDGEVVVWTSSLKRAIRTAQYISQPKVVMRALDEIDAGVCDGMTYEEIQ
. ..| | ||.|.||..|. ||..|||.| .|..|| .. |. .|..| |.||..||..|. | .|. .| |||.|...|.|.||..
trlyLvRHGetewnaegrlqgdvpLtelGreqaralaellael........glkfdavysSpllRarqTaeiiglpvevdprlrEidfgdwegltleela
EKMPDERAARDSDKLQYRYPRGESYEDVIQRLEPLLLELERtKSPVLIVSHQATLRCLYSYLKGRVKEECPFINIPLHTLIQLSPKAYGC
||.|.| ||. |.| ||.|.|||..||..|..|.| || . ..||.|.|....|.|..|| | ||....|.| .... |... .|.
ekypeelaawlrdpldyrppggEsladvaaRvlpaleella.ggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggw
|
|||||||||
0037864 | Phosphoglycerate mutase-like | 382-578 | 3.5e-45 | 146.3 | In-house | 1-202 (211) | alignment | ||
Range on Protein: 382-578
Range on HMM: 1-202/211.0
MNLHLHPRPIWLTRQGESEFNAQNRIGG--DSDLTERGDNYAHQLAVWISEWcsKVRADgydgevVVWTSSLKRAIRTAQYI----S---QPKVVMRALD
|.|.|... ..|.| ||.|.||..|. | |..|||.| .|..|. .. .. ... | .|..| |.|||.||..| . | .|. .|
MslnllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadl..glpfd......avysSpllRaiqTaeiilealglpllpvevdprlr
EIDAGVCDGMTYEEIQEKMPDERAARDSDKLQYRYPRGESYEDVIQRLEPLLLELERTK----SPVLIVSHQATLRCLYSYLKGRVKEECPFINIPLHTL
|.| |...|.|.|||.||.|.| .|. |.. .|.| |||..||..|..|.| || .. . ||.|||...||.|..|| | ||.. .|.| ...
ErdfgalegltleeiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsleellrlnlpngsv
IQLSPKAYGC
. | . .|.
tvlelddggw
|
|||||||||
0036777 | Phosphoglycerate mutase-like | 389-577 | 3.5e-45 | 146.8 | In-house | 3-221 (247) | alignment | ||
Range on Protein: 389-577
Range on HMM: 3-221/247.0
RPIWLTRQGESEFNAQNRIGG--DSDLTERGDNYAHQLAVWISEWcsKVRADgydgevVVWTSSLKRAIRTAQYI----S---QPKVVMRALDEIDAGVC
. ..|.| ||.|.||..|. | |..|||.| .|..|. ...| ... | .|..| |.|||.||..| | ||. .| |.| |..
krlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkel..glpfd......avysSpllRAiqTaeiilealglsllpvvvdprLrErdyGal
DGMTYEEIQEKMPDERAARDSDKLQYRY-------------------------PRGESYEDVIQRLEPLLLELERT----KSPVLIVSHQATLRCLYSYL
.|.|..||.||.|.| .|. |.. ||. | |||..||..|..| | || .. . ||.|||...||.|..||
egltkaeiaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayl
KGRVKEECPFINIPLHTLIQLSPKAYG
| |. . .|.| .... | ...|
lglsledilrlnlpngsitvleldddg
|
|||||||||
0043909 | Phosphoglycerate mutase-like | 389-581 | 6.6e-45 | 145.8 | In-house | 3-229 (249) | alignment | ||
Range on Protein: 389-581
Range on HMM: 3-229/249.0
RPIWLTRQGESEFNAQNRIGG--DSDLTERGDNYAHQLAVWISEWcsKVRADgydgevVVWTSSLKRAIRTAQYI----S---QPKVVMRALDEIDAGVC
. ..| | ||.|.||..|. | ||.|||.| |..|. ...| ... | .|..| |||||.||..| | .|. .| |.| |..
krlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkel..gipfd......avysSplkRAiqTaeiileelgldklpvevdprLrErdfGal
DGMTYEEIQEKMPDERAARDS-----------------------------DKLQYRYPRGESYEDVIQRLEPLLLELERT----KSPVLIVSHQATLRCL
.|.|..|| ||.|.| .|. |.| .|.|.|||..||..|..| | || .. . ||||.|...||.|
egltkaeiaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlral
YSYLKGRVKEECPFINIPLHTLIQLSPKAYGCEET
..|| |. |... .|.| .... | ....|...
layllglsledilrlnlpngsitvlelddggkpvv
|
|||||||||
0049178 | Phosphoglycerate mutase-like | 389-580 | 4.6e-44 | 143.2 | In-house | 4-223 (243) | alignment | ||
Range on Protein: 389-580
Range on HMM: 4-223/243.0
RPIWLTRQGESEFNAQNRIGG--DSDLTERGDNYAHQLAVWISEWcsKVRADgydgevVVWTSSLKRAIRTAQYI----S---QPKVVMRALDEIDAGVC
. ..| | ||.|.||..|. | ||.|||.| |..|. ...|. ... | .|..| |||||.||..| | ||. .| |.| |..
trlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellael..glkfd......avysSplkRaiqTaeiilealglpllpvvvdprLrErdfGal
DGMTYEEIQEKMPDERAARDSDKLQYRY-----------------------PRGESYEDVIQRLEPLLLELERT----KSPVLIVSHQATLRCLYSYLKG
.|.|..||..|.|.| .|. |.. .|. | |||..||..|..| | || .. . ||.|.|....|.|...| |
egltkaeiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllg
RVKEECPFINIPLHTLIQLSPKAYGCEE
|| . .|.| .... |. . .|.
lpleellrlnlpngsvtvlelddggwvl
|
|||||||||
0051064 | Phosphoglycerate mutase-like | 388-577 | 4e-43 | 140.4 | In-house | 3-222 (241) | alignment | ||
Range on Protein: 388-577
Range on HMM: 3-222/241.0
PRPIWLTRQGESEFNAQNRIGG--DSDLTERGDNYAHQLAVWISEWCSKVRadgydgevVVWTSSLKRAIRTAQYIS-------QPKVVMRALDEIDAGV
.. ..| | ||||.||..|. | |..|||.| .|..|. ..... |. .|..| |.|||.||..| | ||. .| ||| |.
mkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfd........avysSpllRaiqTaeiiaealglpllpvvvdprlrEidfga
CDGMTYEEIQEKMPDERAARDSDKLQYRY-------------------------PRGESYEDVIQRLEPLLLELERT----KSPVLIVSHQATLRCLYSY
..|.|.|||.||.|.| .|.. |.| .|. |.|||..||..|..| | || .. . ||.|||....|.|..|
legltleeiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallay
LKGRVKEECPFINIPLHTLIQLSPKAYG
| |. || . .|.| .... | ...|
llglpleellrlnlpngsvtvleldddg
|
|||||||||
0036887 | Phosphoglycerate mutase-like | 389-578 | 4e-43 | 139.6 | In-house | 2-190 (202) | alignment | ||
Range on Protein: 389-578
Range on HMM: 2-190/202.0
RPIWLTRQGESEFNAQNRIGG--DSDLTERGDNYAHQLAVWISewcsKVRADgydgevVVWTSSLKRAIRTAQYI----SQPKVVMRALDEIDAGVCDGM
. ..|.| ||.|.|...|. | |..|||.| .|..|. ... ... | .|..| |.|||.||..| . | .|. .| ||| |...|.
trlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla....glpfd......avysSpllRaiqTaeiiaealglpvivdprlrEidfgalegl
TYEEIQEKMPDERAARDSDKLQYRYPRGESYEDVIQRLEPLLLELERT--KSPVLIVSHQATLRCLYSYLKGRVKEECPFIN-IPLHTLIQLSPKAYGC
|.|||.||.|.| ||. |.. .|.|.|||..||..|....| || .. . ||.|||...||.|..|| |. |...... .| .... |. ...|.
tleeiaekypeelaawlrdpydfrppggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlelddggw
|
|||||||||
0048955 | Phosphoglycerate mutase-like | 391-575 | 3.2e-42 | 137.3 | In-house | 3-217 (240) | alignment | ||
Range on Protein: 391-575
Range on HMM: 3-217/240.0
IWLTRQGESEFNAQNRIGG--DSDLTERGDNYAHQLAVWISEWcsK--VRadgydgevVVWTSSLKRAIRTAQYI----S---QPKVVMRALDEIDAGVC
..| | ||||.||..|. | |..|||.| .|..|. ..... . .|..| |.|||.||..| . | ||. .| |.| |..
lyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadl..gikfd........lvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgal
DGMTYEEIQEKMPDERAARDSDKLQYRY-------------------------PRGESYEDVIQRLEPLLLELER----TKSPVLIVSHQATLRCLYSYL
.|.|..||.||.|.| ... |.| .|. |.|||..||..|... | || . . . ||.|||....|.|..||
egltldeiaekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayl
KGRVKEECPFINIPLHTLIQLSPKA
|. || . .||| . .. |. .
lglpleeilrlnipngsvtvleldd
|
|||||||||
0050036 | Phosphoglycerate mutase-like | 391-571 | 3.3e-38 | 122.9 | In-house | 3-165 (171) | alignment | ||
Range on Protein: 391-571
Range on HMM: 3-165/171.0
IWLTRQGESEFNAQNRIGG--DSDLTERGDNYAHQLAVWIsewcskvradgydGEVVVWTSSLKRAIRTAQYISQPKVVMRALDEIDAGVCDGMTYEEIQ
..| | ||.|.|...|. | |..|||.| .|..|. .. .|..| |.||..||..| | .|. .| |.| |...|.|..||.
lyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.............pfdavysSpllRArqTaelillpvivdprLrErdfGawegltldeia
EKMPDeraaRDSDKLQYRYPRGESYEDVIQRLEPLLLELErtkSPVLIVSHQATLRCLYSYLKGRVKEECPFINIPLHTLIQL
.|.|. .. |.| ...| |||..||..|. | | || ..||.|.|....|.|...| | || . ...| .... |
akype....wlldlldlappggEsladvlaRvlpaleell...gnvlvvaHggvirallalllglsleeilrlelpngsvlvl
|
|||||||||
His_Phos_1 | Histidine phosphatase superfamily (branch 1) | 391-546 | 1.5e-33 | 109.0 | Pfam-A | 2-158 (158) | alignment | ||
Range on Protein: 391-546
Range on HMM: 2-158/158.0
IWLTRQGESEFNAQNRIGGDSD--LTERGDNYAHQLAVWISEwcskvradgYDGEVV-VWTSSLKRAIRTAQYISQPK----VVMRALDEIDAGVCDGMT
..|.| ||||.|...|. |.|| |||.| . |..|. .... | .. |.|| ||||| ||..... . .| |.|.|...|..
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkr.........adlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglp
YEEIQEKMPDERAARDSDKLQYRYPRGESYEDVIQRLEPLLLELE---RTKSPVLIVSHQATLRCL
.||..|. |.| .....|| ..|.|.|||..||..|..|.| || ... ||||||...||.|
keevkeefpeeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
|
|||||||||
His_Phos_1 | Histidine phosphatase superfamily (branch 1) | 391-546 | 1.5e-33 | 109.0 | In-house | 2-158 (158) | alignment | ||
Range on Protein: 391-546
Range on HMM: 2-158/158.0
IWLTRQGESEFNAQNRIGGDSD--LTERGDNYAHQLAVWISEwcskvradgYDGEVV-VWTSSLKRAIRTAQYISQPK----VVMRALDEIDAGVCDGMT
..|.| ||||.|...|. |.|| |||.| . |..|. .... | .. |.|| ||||| ||..... . .| |.|.|...|..
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkr.........adlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglp
YEEIQEKMPDERAARDSDKLQYRYPRGESYEDVIQRLEPLLLELE---RTKSPVLIVSHQATLRCL
.||..|. |.| .....|| ..|.|.|||..||..|..|.| || ... ||||||...||.|
keevkeefpeeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
|
|||||||||
subfamily_TIGAR_pd | Subfamily TIGAR | 391-527 | 3.2e-10 | 32.0 | In-house | 3-134 (222) | alignment | ||
Range on Protein: 391-527
Range on HMM: 3-134/222.0
IWLTRQGESEFNAQNRIGGDS--DLTERGDNYAHQLAVWISEwcskvradgyDGEVVVWTSSLKRAIRTAQYISQPK--------VVMRALDEIDAGVCD
... | ||.|||... . | . |.|.| . | ..| .|. .. . . .| |.|| .||..| .. .. | | . ||
livVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsn..........ekinyifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvye
GMTYEEIQEKMPDERaardsDKLQYRYPRGESYEDVIQRLEPLLLEL
|....|..| . .. . . . ||| | . .|| . | ||
Gvaldelrellkaag.....nvpsfvpegGesieqlelrlvaaleel
|
|||||||||
AAA_33 | AAA domain | 184-336 | 1.4e-09 | 28.5 | Pfam-A | 1-139 (143) | alignment | ||
Range on Protein: 184-336
Range on HMM: 1-139/143.0
VLVMVGLPARGKTYVARKICRMLNWMLVPAKVfnvgEYRRLRIgagqphdffDPHNPEGIKARLH-MAVAALDDMISWLHNGGRVGIYDATNSTNERRQL
....||||. ||...|..... | . .. . . . |||. . .... .|.. . ..| ... . || | |||| ..|.|.
lvllvGlpGsGKstlaerllkklgyvrlsqdt....lrrrlfg.........tdqqsltdytrvlkrlyqilnklarkalsagrsvivdatnlsreerar
VEKRCTREKMTVVYVESICnDASVIEHNIKETKLLSpDYQGVDPSKAVQDFRDR
. | . | .. | | . . ......... . . |.. | .|......|
fvklakrlgvpvrivylev.peetlaeRlakRerng.ddrsevpeealdrmlar
|
|||||||||
subfamily_PGAM_pd | Subfamily PGAM | 392-461 | 5.3e-08 | 24.4 | In-house | 4-67 (248) | alignment | ||
Range on Protein: 392-461
Range on HMM: 4-67/248.0
WLTRQGESEFNAQNRIGG--DSDLTERGDNYAHQLAVWISEwcskvraDGYDGEvVVWTSSLKRAIRTAQYI
| | ||||.| .|.. | | .|.|.| . |.... . . ... . .|.|| ||||..|.. |
vllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkq.......anlefd.ivytSvlkRaqqTlevi
|
|||||||||
subfamily_PGAM_pd | Subfamily PGAM | 495-564 | 8.9e-08 | 23.7 | In-house | 138-208 (248) | alignment | ||
Range on Protein: 495-564
Range on HMM: 138-208/248.0
RAArdsDKLQYRYPRGESYEDVIQRLEPLLLE----LERTKSPVLIVSHQATLRCLYSYLKGRVKEECPFINIP
| . .. . ..|. || ..|..||.|.| | .... ||||.| ..|.| ..|.| .|. ...|
rye...elkeeelPesEslkevveRllpvlneeilkeikegkrvlivahgnsvrallkvlegisdeaikeldlp
|
|||||||||
AAA_17 | AAA domain | 186-273 | 6e-06 | 17.7 | Pfam-A | 3-78 (121) | alignment | ||
Range on Protein: 186-273
Range on HMM: 3-78/121.0
VMVGLPARGKTYVARKICRMLNwmlvpAKVFNVGEYRRLRIGAGQPHDFFDPhnpegIKARLHMAVAALD------DMISWLHNGgrvgiydaT
. .| |. ||...|..... |. .|.. ....| . .. ...... . | .. | || | ||. .| .
aitGppGsGKsTlakeLaerlg.....lpvlslddllreeglkelddgeres.....kdadadllaaildglaakkdtlswvidg........a
|