Gene DDB_G0282759 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP087_AA protein Get Run
DdisP087_AA_381-583 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PFKFB_pd Subfamily PFKFB 383-585 4.5e-86 279.4 In-house 1-195 (198) alignment 
Range on Protein: 383-585
Range on HMM: 1-195/198.0
NLHLHPRPIWLTRQGESEFNAQNRIGGDSDLTERGDNYAHQLAVWISEwcskvraDGYDgEVVVWTSSLKRAIRTAQYISQPKVVMRALDEIDAGVCDGM
|.||.|| |.|.|.|||| |...||||||.|||||..||..|| .|.|       . .. |. ||||.|||.|.||.... ||  ..||||.|||.|||.
nihlkpreiylvRhGeseknkkgriggdseLterGveyakklakfike.......enlk.elrvwtselkrtiqTaellglpkeqwkaLdeldaGkcdgl

TYEEIQEKMPDERAARDSDKLQYRYPRGESYEDVIQRLEPLLLELERTKSPVLIVSHQATLRCLYSYLKGRVKEECPFINIPLHTLIQLSPKAYGCEETT
|||||.||.|.| ..|..||..|||||||||||..|||||..|||||... |||..|||.||.|..||. .  ||.|....||||.|.|.|.||||. ..
tyeeikekfpeefkerkkdkyryryprgEsyedlvqRlepvileLereqenvliiaHqavlrvllaylldksaeelpylkvplhtvikltpvaYgckvel

FKL
.||
lkl
6PF2K 6-phosphofructo-2-kinase 176-388 2.3e-80 259.2 Pfam-A 7-223 (223) alignment 
Range on Protein: 176-388
Range on HMM: 7-223/223.0
TGLDKEKIVLVMVGLPARGKTYVARKICRMLNWMLVPAKVFNVGEYRRLRIGAGQPHDFFDPHNPEGIKARLHMAVAALDDMISWLH-NGGRVGIYDATN
. |...|.|.|.||||||||||...|..|.|.|. |..||||||.|||    | .  .||.|.|.|..|.| ..| |||.|....|. ..| |.|.||||
knlknsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgkyrreavkalsdaeffrpdneealklreklalaalkdllkylneeegqvaifDAtN

STNERRQLVEKRCTREKMTVVYVESICNDASVIEHNIKETKLLSPDYQGVDPSKAVQDFRDRINHYLKVYETVE---GEKTRYIKLFDVGKKIEVNNITG
.| |||.|. ........ |...||.|.| ..|..|||| || ||||.. ....|..||  |...| |.|| ..    |. .|||..||||.. |||..|
ttrerRklilefveennlkvlflesvcsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyeplddeedeelsyIkvidvgkslvvnnvqg

YIPSRVVFFLMNLHLHP
|. ||.|..|.|.||.|
ylqsrivyyllNihlkp
0039931 Phosphoglycerate mutase-like 391-583 1.5e-50 163.9 In-house 2-185 (219) alignment 
Range on Protein: 391-583
Range on HMM: 2-185/219.0
IWLTRQGESEFNAQNRIGGDSDLTERGDNYAHQLAVWISEWcsK--VradgydgeVVVWTSSLKRAIRTAQYISQPKVVMRALDEIDAGVCDGMTYEEIQ
..|.| ||.|.|...|. |||.|||||  .|..|. .....  .  .         .|..| |.|||.||..|  | ... .| |||.|...|.|.|||.
lyLvRHGetewnvegrlqgdspLterGreqaralgerlkdl..glpf........davysSpllRaiqTaeiiglpveidprLrEidfgdlegltleeia

EKMPDERAARDSDKLQYRYPRGESYEDVIQRLEPLLLELERtKSPVLIVSHQATLRCLYSYLKGRVKEECPFINIPLHTLIQLSPKAYGCEETTF
||.|.| ||.  |.. ||.|.|||..||..|..|.| ||..  ..||.|||....|.|..|| |   ||.. .|.| .... |.....|.  ...
ekypeelaawlrdpydyrppggEsladvvaRvlpaleella.genvlvVsHggvirallayllglsleeilrlnlpngsvtvlelddggwvlvll
0035570 Phosphoglycerate mutase-like 391-577 6.7e-50 161.8 In-house 2-179 (219) alignment 
Range on Protein: 391-577
Range on HMM: 2-179/219.0
IWLTRQGESEFNAQNRIGGDSDLTERGDNYAHQLAVWISEWcsKVRADgydgevVVWTSSLKRAIRTAQYISQPKVVMRALDEIDAGVCDGMTYEEIQEK
..|.| ||.|.|...|. ||..|||||  .|..|. ....   ... |      .|..| |.|||.||..|  | ... .| |||.|...|.|..||.||
lyLvRHGetewnlegrlqgdvpLterGreqaralgealadl..gipfd......avysSpllRaiqTaeiiglpveidprLrEidfgdlegltldeiaek

MPDERAARDSDKLQYRYPRGESYEDVIQRLEPLLLELeRTKSPVLIVSHQATLRCLYSYLKGRVKEECPFINIPLHTLIQLSPKAYG
.|.| ||.  |.. ||.|.|||..||..|..|.| || .  ..||.|||....|.|..|| |   ||....|.| .... |.....|
ypeelaawlrdpydyrppggEsladvvaRvlpaleel.edgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggg
0053607 Phosphoglycerate mutase-like 389-578 2.4e-46 149.9 In-house 2-182 (191) alignment 
Range on Protein: 389-578
Range on HMM: 2-182/191.0
RPIWLTRQGESEFNAQNRIGGDSDLTERGDNYAHQLAVWISEWcskvradgYDGEVVVWTSSLKRAIRTAQYISQPKVVMRALDEIDAGVCDGMTYEEIQ
. ..| | ||.|.||..|. ||..|||.|  .|..|| .. |.             .|..| |.||..||..|. | .|. .| |||.|...|.|.||..
trlyLvRHGetewnaegrlqgdvpLtelGreqaralaellael........glkfdavysSpllRarqTaeiiglpvevdprlrEidfgdwegltleela

EKMPDERAARDSDKLQYRYPRGESYEDVIQRLEPLLLELERtKSPVLIVSHQATLRCLYSYLKGRVKEECPFINIPLHTLIQLSPKAYGC
||.|.| ||.  |.| ||.|.|||..||..|..|.| || .  ..||.|.|....|.|..|| |   ||....|.| .... |... .|.
ekypeelaawlrdpldyrppggEsladvaaRvlpaleella.ggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggw
0037864 Phosphoglycerate mutase-like 382-578 3.5e-45 146.3 In-house 1-202 (211) alignment 
Range on Protein: 382-578
Range on HMM: 1-202/211.0
MNLHLHPRPIWLTRQGESEFNAQNRIGG--DSDLTERGDNYAHQLAVWISEWcsKVRADgydgevVVWTSSLKRAIRTAQYI----S---QPKVVMRALD
|.|.|... ..|.| ||.|.||..|. |  |..|||.|  .|..|. .. ..  ... |      .|..| |.|||.||..|    .    | .|. .| 
MslnllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadl..glpfd......avysSpllRaiqTaeiilealglpllpvevdprlr

EIDAGVCDGMTYEEIQEKMPDERAARDSDKLQYRYPRGESYEDVIQRLEPLLLELERTK----SPVLIVSHQATLRCLYSYLKGRVKEECPFINIPLHTL
|.| |...|.|.|||.||.|.| .|.  |.. .|.| |||..||..|..|.| || ..     . ||.|||...||.|..|| |   ||.. .|.| ...
ErdfgalegltleeiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsleellrlnlpngsv

IQLSPKAYGC
. |  . .|.
tvlelddggw
0036777 Phosphoglycerate mutase-like 389-577 3.5e-45 146.8 In-house 3-221 (247) alignment 
Range on Protein: 389-577
Range on HMM: 3-221/247.0
RPIWLTRQGESEFNAQNRIGG--DSDLTERGDNYAHQLAVWISEWcsKVRADgydgevVVWTSSLKRAIRTAQYI----S---QPKVVMRALDEIDAGVC
. ..|.| ||.|.||..|. |  |..|||.|  .|..|. ...|   ... |      .|..| |.|||.||..|         | ||. .| |.| |..
krlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkel..glpfd......avysSpllRAiqTaeiilealglsllpvvvdprLrErdyGal

DGMTYEEIQEKMPDERAARDSDKLQYRY-------------------------PRGESYEDVIQRLEPLLLELERT----KSPVLIVSHQATLRCLYSYL
.|.|..||.||.|.| .|.  |.. ||.                         | |||..||..|..| | || ..     . ||.|||...||.|..||
egltkaeiaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayl

KGRVKEECPFINIPLHTLIQLSPKAYG
 |   |. . .|.| .... |  ...|
lglsledilrlnlpngsitvleldddg
0043909 Phosphoglycerate mutase-like 389-581 6.6e-45 145.8 In-house 3-229 (249) alignment 
Range on Protein: 389-581
Range on HMM: 3-229/249.0
RPIWLTRQGESEFNAQNRIGG--DSDLTERGDNYAHQLAVWISEWcsKVRADgydgevVVWTSSLKRAIRTAQYI----S---QPKVVMRALDEIDAGVC
. ..| | ||.|.||..|. |  ||.|||.|   |..|. ...|   ... |      .|..| |||||.||..|         | .|. .| |.| |..
krlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkel..gipfd......avysSplkRAiqTaeiileelgldklpvevdprLrErdfGal

DGMTYEEIQEKMPDERAARDS-----------------------------DKLQYRYPRGESYEDVIQRLEPLLLELERT----KSPVLIVSHQATLRCL
.|.|..|| ||.|.| .|.                               |.| .|.|.|||..||..|..| | || ..     . ||||.|...||.|
egltkaeiaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlral

YSYLKGRVKEECPFINIPLHTLIQLSPKAYGCEET
..|| |.  |... .|.| .... | ....|... 
layllglsledilrlnlpngsitvlelddggkpvv
0049178 Phosphoglycerate mutase-like 389-580 4.6e-44 143.2 In-house 4-223 (243) alignment 
Range on Protein: 389-580
Range on HMM: 4-223/243.0
RPIWLTRQGESEFNAQNRIGG--DSDLTERGDNYAHQLAVWISEWcsKVRADgydgevVVWTSSLKRAIRTAQYI----S---QPKVVMRALDEIDAGVC
. ..| | ||.|.||..|. |  ||.|||.|   |..|. ...|.  ... |      .|..| |||||.||..|         | ||. .| |.| |..
trlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellael..glkfd......avysSplkRaiqTaeiilealglpllpvvvdprLrErdfGal

DGMTYEEIQEKMPDERAARDSDKLQYRY-----------------------PRGESYEDVIQRLEPLLLELERT----KSPVLIVSHQATLRCLYSYLKG
.|.|..||..|.|.| .|.  |.. .|.                       | |||..||..|..| | || ..     . ||.|.|....|.|...| |
egltkaeiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllg

RVKEECPFINIPLHTLIQLSPKAYGCEE
   || . .|.| .... |. . .|.  
lpleellrlnlpngsvtvlelddggwvl
0051064 Phosphoglycerate mutase-like 388-577 4e-43 140.4 In-house 3-222 (241) alignment 
Range on Protein: 388-577
Range on HMM: 3-222/241.0
PRPIWLTRQGESEFNAQNRIGG--DSDLTERGDNYAHQLAVWISEWCSKVRadgydgevVVWTSSLKRAIRTAQYIS-------QPKVVMRALDEIDAGV
.. ..| | ||||.||..|. |  |..|||.|  .|..|. .....  |.         .|..| |.|||.||..|         | ||. .| ||| |.
mkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfd........avysSpllRaiqTaeiiaealglpllpvvvdprlrEidfga

CDGMTYEEIQEKMPDERAARDSDKLQYRY-------------------------PRGESYEDVIQRLEPLLLELERT----KSPVLIVSHQATLRCLYSY
..|.|.|||.||.|.| .|.. |.| .|.                         |.|||..||..|..| | || ..     . ||.|||....|.|..|
legltleeiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallay

LKGRVKEECPFINIPLHTLIQLSPKAYG
| |.  || . .|.| .... |  ...|
llglpleellrlnlpngsvtvleldddg
0036887 Phosphoglycerate mutase-like 389-578 4e-43 139.6 In-house 2-190 (202) alignment 
Range on Protein: 389-578
Range on HMM: 2-190/202.0
RPIWLTRQGESEFNAQNRIGG--DSDLTERGDNYAHQLAVWISewcsKVRADgydgevVVWTSSLKRAIRTAQYI----SQPKVVMRALDEIDAGVCDGM
. ..|.| ||.|.|...|. |  |..|||.|  .|..|. ...    ... |      .|..| |.|||.||..|    . | .|. .| ||| |...|.
trlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla....glpfd......avysSpllRaiqTaeiiaealglpvivdprlrEidfgalegl

TYEEIQEKMPDERAARDSDKLQYRYPRGESYEDVIQRLEPLLLELERT--KSPVLIVSHQATLRCLYSYLKGRVKEECPFIN-IPLHTLIQLSPKAYGC
|.|||.||.|.| ||.  |.. .|.|.|||..||..|....| || ..   . ||.|||...||.|..|| |.  |...... .| .... |. ...|.
tleeiaekypeelaawlrdpydfrppggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlelddggw
0048955 Phosphoglycerate mutase-like 391-575 3.2e-42 137.3 In-house 3-217 (240) alignment 
Range on Protein: 391-575
Range on HMM: 3-217/240.0
IWLTRQGESEFNAQNRIGG--DSDLTERGDNYAHQLAVWISEWcsK--VRadgydgevVVWTSSLKRAIRTAQYI----S---QPKVVMRALDEIDAGVC
..| | ||||.||..|. |  |..|||.|  .|..|. .....     .         .|..| |.|||.||..|    .    | ||. .| |.| |..
lyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadl..gikfd........lvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgal

DGMTYEEIQEKMPDERAARDSDKLQYRY-------------------------PRGESYEDVIQRLEPLLLELER----TKSPVLIVSHQATLRCLYSYL
.|.|..||.||.|.| ...  |.| .|.                         |.|||..||..|... | || .    . . ||.|||....|.|..||
egltldeiaekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayl

KGRVKEECPFINIPLHTLIQLSPKA
 |.  || . .||| . .. |. . 
lglpleeilrlnipngsvtvleldd
0050036 Phosphoglycerate mutase-like 391-571 3.3e-38 122.9 In-house 3-165 (171) alignment 
Range on Protein: 391-571
Range on HMM: 3-165/171.0
IWLTRQGESEFNAQNRIGG--DSDLTERGDNYAHQLAVWIsewcskvradgydGEVVVWTSSLKRAIRTAQYISQPKVVMRALDEIDAGVCDGMTYEEIQ
..| | ||.|.|...|. |  |..|||.|  .|..|. ..                .|..| |.||..||..|  | .|. .| |.| |...|.|..||.
lyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.............pfdavysSpllRArqTaelillpvivdprLrErdfGawegltldeia

EKMPDeraaRDSDKLQYRYPRGESYEDVIQRLEPLLLELErtkSPVLIVSHQATLRCLYSYLKGRVKEECPFINIPLHTLIQL
.|.|.    .. |.| ...| |||..||..|. | | ||    ..||.|.|....|.|...| |   || . ...| .... |
akype....wlldlldlappggEsladvlaRvlpaleell...gnvlvvaHggvirallalllglsleeilrlelpngsvlvl
His_Phos_1 Histidine phosphatase superfamily (branch 1) 391-546 1.5e-33 109.0 Pfam-A 2-158 (158) alignment 
Range on Protein: 391-546
Range on HMM: 2-158/158.0
IWLTRQGESEFNAQNRIGGDSD--LTERGDNYAHQLAVWISEwcskvradgYDGEVV-VWTSSLKRAIRTAQYISQPK----VVMRALDEIDAGVCDGMT
..|.| ||||.|...|. |.||  |||.| . |..|. ....          | ..  |.|| ||||| ||..... .        .| |.|.|...|..
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkr.........adlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglp

YEEIQEKMPDERAARDSDKLQYRYPRGESYEDVIQRLEPLLLELE---RTKSPVLIVSHQATLRCL
.||..|. |.| .....|| ..|.|.|||..||..|..|.| ||    ...  ||||||...||.|
keevkeefpeeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
His_Phos_1 Histidine phosphatase superfamily (branch 1) 391-546 1.5e-33 109.0 In-house 2-158 (158) alignment 
Range on Protein: 391-546
Range on HMM: 2-158/158.0
IWLTRQGESEFNAQNRIGGDSD--LTERGDNYAHQLAVWISEwcskvradgYDGEVV-VWTSSLKRAIRTAQYISQPK----VVMRALDEIDAGVCDGMT
..|.| ||||.|...|. |.||  |||.| . |..|. ....          | ..  |.|| ||||| ||..... .        .| |.|.|...|..
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkr.........adlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglp

YEEIQEKMPDERAARDSDKLQYRYPRGESYEDVIQRLEPLLLELE---RTKSPVLIVSHQATLRCL
.||..|. |.| .....|| ..|.|.|||..||..|..|.| ||    ...  ||||||...||.|
keevkeefpeeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
subfamily_TIGAR_pd Subfamily TIGAR 391-527 3.2e-10 32.0 In-house 3-134 (222) alignment 
Range on Protein: 391-527
Range on HMM: 3-134/222.0
IWLTRQGESEFNAQNRIGGDS--DLTERGDNYAHQLAVWISEwcskvradgyDGEVVVWTSSLKRAIRTAQYISQPK--------VVMRALDEIDAGVCD
... | ||.|||... . | .   |.|.| . | ..|  .|.          .. . . .| |.|| .||..| ..         ..   | | . ||  
livVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsn..........ekinyifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvye

GMTYEEIQEKMPDERaardsDKLQYRYPRGESYEDVIQRLEPLLLEL
|....|..| .  ..     .  .   . ||| | . .|| . | ||
Gvaldelrellkaag.....nvpsfvpegGesieqlelrlvaaleel
AAA_33 AAA domain 184-336 1.4e-09 28.5 Pfam-A 1-139 (143) alignment 
Range on Protein: 184-336
Range on HMM: 1-139/143.0
VLVMVGLPARGKTYVARKICRMLNWMLVPAKVfnvgEYRRLRIgagqphdffDPHNPEGIKARLH-MAVAALDDMISWLHNGGRVGIYDATNSTNERRQL
....||||. ||...|..... | . .. . .    . |||.          . ....   .|..  . ..| ... .    ||  | |||| ..|.|. 
lvllvGlpGsGKstlaerllkklgyvrlsqdt....lrrrlfg.........tdqqsltdytrvlkrlyqilnklarkalsagrsvivdatnlsreerar

VEKRCTREKMTVVYVESICnDASVIEHNIKETKLLSpDYQGVDPSKAVQDFRDR
. | . | .. |  |   . . ......... .  . |..   | .|......|
fvklakrlgvpvrivylev.peetlaeRlakRerng.ddrsevpeealdrmlar
subfamily_PGAM_pd Subfamily PGAM 392-461 5.3e-08 24.4 In-house 4-67 (248) alignment 
Range on Protein: 392-461
Range on HMM: 4-67/248.0
WLTRQGESEFNAQNRIGG--DSDLTERGDNYAHQLAVWISEwcskvraDGYDGEvVVWTSSLKRAIRTAQYI
 | | ||||.| .|.. |  | .|.|.| . |....  . .        ... . .|.|| ||||..|.. |
vllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkq.......anlefd.ivytSvlkRaqqTlevi
subfamily_PGAM_pd Subfamily PGAM 495-564 8.9e-08 23.7 In-house 138-208 (248) alignment 
Range on Protein: 495-564
Range on HMM: 138-208/248.0
RAArdsDKLQYRYPRGESYEDVIQRLEPLLLE----LERTKSPVLIVSHQATLRCLYSYLKGRVKEECPFINIP
| .   .. . ..|. || ..|..||.|.| |      .... ||||.|  ..|.| ..|.|  .|.   ...|
rye...elkeeelPesEslkevveRllpvlneeilkeikegkrvlivahgnsvrallkvlegisdeaikeldlp
AAA_17 AAA domain 186-273 6e-06 17.7 Pfam-A 3-78 (121) alignment 
Range on Protein: 186-273
Range on HMM: 3-78/121.0
VMVGLPARGKTYVARKICRMLNwmlvpAKVFNVGEYRRLRIGAGQPHDFFDPhnpegIKARLHMAVAALD------DMISWLHNGgrvgiydaT
. .| |. ||...|..... |.      .|.. ....| .  .. ......      . | ..   | ||      |  ||. .|        .
aitGppGsGKsTlakeLaerlg.....lpvlslddllreeglkelddgeres.....kdadadllaaildglaakkdtlswvidg........a