Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_PHP_pd | Subfamily PHP | 28-145 | 6.3e-38 | 119.2 | In-house | 8-112 (114) | alignment | ||
Range on Protein: 28-145
Range on HMM: 8-112/114.0
VIDHIGDEKYVILELtpyvTTDSEGKPLKYLEKRYVLASTDTEAYhsgqkqwyvENTKELHKKKWRSPECLGGGIMTIDQNNKSIKTFGTSYGYGDPPIE
||. |..|||..|| |||||||. |.....|. |......| |..|| ..|......|||||....|...|.||..|.|.|.|....|
didskGkfkYvliel....ttdsegkksktivrgyskaeyhadiy.........eevkeeleklglkakclGGGriehdkekkkikvyGyskgfGkadhe
ILKSILNTVYPNYNLDIT
|.|.||.|.||.|...|.
iakeilktkypdykitis
|
|||||||||
0053050 | PHP14-like | 24-144 | 4.4e-28 | 87.0 | In-house | 5-116 (118) | alignment | ||
Range on Protein: 24-144
Range on HMM: 5-116/118.0
TYECVIDHIGDEKYVILELTPYVTTDSEGKPLkylekRYVLASTDTEAYHSgqkQWYVENTKELHKKKWRsPECLGGGIMTIDQNNKSIKTFGTSYGYGD
..|. ||. | |||....| . .|||.||. .... .... .||. ..| |..|||.| ... ||||||....|...|.||..|.|.|.|.
vpevdideeGvfkYvlikvtlkgltdsggkes.....klivrglkkaeyHa...diyeevskeleklgld.leclGGGriehdsekkkikvyGyslgfGk
PPIEILKSILNTVYPNYNLDI
. || ..||.|.||.|....
adheialeilktkypdyeitl
|
|||||||||
Ocnus | Janus/Ocnus family (Ocnus) | 40-141 | 2e-25 | 78.6 | Pfam-A | 1-107 (108) | alignment | ||
Range on Protein: 40-141
Range on HMM: 1-107/108.0
LELTPYVTTDSEGKpLKYL----------EKRYVLASTDTEAYHSgqkQWYVENTKELHKKKWrSPECLGGGIMTIDQNNKSIKTFGTSYGYGDPPIEIL
|. .| |..|.||| .||. |...|...... .||. ..| ...|||.| .. . |||||| ...|...|.||..|.|.|.|... ||
LakvpevdideeGk.fkYvlikvkikekdeskevvrglkkaeyHa...diyekvkkeleklgl.eteclGGGriehdeekkkikvyGyskgfGkadheia
KSILNTVYPNYN
|.||.. |..|.
keilkkkykdye
|
|||||||||
Ocnus | Janus/Ocnus family (Ocnus) | 40-141 | 2e-25 | 78.6 | In-house | 1-107 (108) | alignment | ||
Range on Protein: 40-141
Range on HMM: 1-107/108.0
LELTPYVTTDSEGKpLKYL----------EKRYVLASTDTEAYHSgqkQWYVENTKELHKKKWrSPECLGGGIMTIDQNNKSIKTFGTSYGYGDPPIEIL
|. .| |..|.||| .||. |...|...... .||. ..| ...|||.| .. . |||||| ...|...|.||..|.|.|.|... ||
LakvpevdideeGk.fkYvlikvkikekdeskevvrglkkaeyHa...diyekvkkeleklgl.eteclGGGriehdeekkkikvyGyskgfGkadheia
KSILNTVYPNYN
|.||.. |..|.
keilkkkykdye
|
|||||||||
PHP | 29-144 | 3.6e-14 | 42.8 | In-house | 11-116 (121) | alignment | |||
Range on Protein: 29-144
Range on HMM: 11-116/121.0
IDHIGDEKYVILELTPYVTTDSEGKplkyleKRYVLASTDTEAYHSgqkQWYVENTKELHKKKwRSPECLGGGIMTIDQNNKSIKTFGTSYGYGDPPIEI
||. | |||....| ..|. . .. |. . ||. | . ..||.|. . |||||| . |...|.|| .| |.||| ..
idpeGvfkyvlirvtskerkdgaaa......skevvrGyaraeyha...diydrvsselekqg.ldaeclGGGriehdseekkikvyGysvgyGkadhav
LKSILNTVYPNYNLDI
|..|.| ||.|....
tkeklktkyPdyeitl
|
|||||||||
Sars6 | Open reading frame 6 from SARS coronavirus | 127-156 | 6e-06 | 12.4 | Pfam-A | 13-43 (62) | alignment | ||
Range on Protein: 127-156
Range on HMM: 13-43/62.0
EILKSILNTVY-PNYNLDITITSEVRELVKP
||| |. | .|||. |.| || | ||
eiliiimrtfriaiwnldvlissivrqlfkP
|
|||||||||
Chordopox_L2 | Chordopoxvirus L2 protein | 12-40 | 8.8e-06 | 11.8 | Pfam-A | 9-37 (87) | alignment | ||
Range on Protein: 12-40
Range on HMM: 9-37/87.0
KKVYQDNKIENQTYECVIDHIGDEKYVIL
|.. ..||.... .|.||.| ....||
ksieeeNklneklldciideiekqqafil
|