Gene DDB_G0274153 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP105_AA protein Get Run
DdisP105_AA_113-641 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Subfamily Dicty-PPM1L-like 115-433 4.5e-166 544.1 In-house 1-305 (305) alignment 
Range on Protein: 115-433
Range on HMM: 1-305/305.0
HHLSFETKYGVNVSQGNRKYQEDRHKVKMGLENNQYLSLFGVFDGHGGDRASNFVKKKIVNCVNKYVKENKAGYSSKNLNSSSSPTGSTSSASSSGSSSS
.||..||||...||...|||||||.|||..||..|.||||||||||.||.|...||||.|..|||||||||.|||.||||....|.....|||.|...||
nhliletkyelyvsansrkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkklveivnkyvkenkvGysaknlnvddlpleaiksaslstdkss

SASSSGGGGGGGGPLNGSSSSIGMPHASTISPTPSSGNSSTSSGASSSGVSSANSPIGVGFDSPGWMKFNHLYNQNNFQQEIQNRSEFLQAALYNTFQFL
..|........|..|||||.|.......||..|.|......||||...|.|..|||.|||||||||||||||||||||..||..|.|.|||||||....|
ldsaesdnkkaGttlngssasvilerertivstasdtevvlssGaiaeglsiinsPkgvgfdspgwmkfnhlynqnnfldeiririeslqaalynygell

DNRYCKKYRQKGDGGTTCLVAllsnPPNAQPLLVVANAGDSRGVLCRNGKAYALSYDHKPGNPKEKQRITSSGGKIEWDFNErIWRVSGILSVSRGIGDi
.||..||.|.|||.....||.    |.|..||||||.|.|...||...|....|||.......||..|..||..|||||||| |.||.....|.||.|| 
vnrllkksrskGdknlkelvi....PnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfne.isrviveeavkrgsgD.

plkkwvicDPEFVVFPLKG
        ....|...||.
........nitlviiklkq
PP2Cc_SM00332 120-431 2.2e-46 151.5 In-house 9-209 (274) alignment 
Range on Protein: 120-431
Range on HMM: 9-209/274.0
ETKYGVNVSQGNRKYQEDRHKVKMGLENNQYLSLFGVFDGHGGDRASNFVKKKIVNCVNKYVKENKAGYssknlnssssptgstssasssgsssssasss
.  ||.. .||.|| .||.| |.. | ...  ..|||||||||.....||.||.......  |. |  .                               
glsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel...............................

ggggggggplngssssigmphastisptpssgnsstssgasssgvssanspigvgfdspgwmkfnhlynqnnfqqeiqnrSEFLQAALYNTFQFLDNRYC
                                                                                ..  ..||.. |. .|... 
................................................................................eddveealkkaflstdeeil

KKYRQKG----DGGTTCLVALLSNPPnaqplLVVANAGDSRGVLCRNGKAYALSYDHKPGNPKEKQRITSSGGKIEWDfneriwRVSGILSVSRGIGDIP
.....|     . |.|..||||..       |.|||.|||| |||||||| .||.|||| ...|..|| ..||..|..      ||.| |.||| .||  
eeeqskelenalsGstavvallkked.....lyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekg......rvngglavsrafGdhf

LK-------KWVICDPEFVVFPL
||       . ....|.  |  |
lkknkklkepyitaepdvkvvtl
0034914 PP2C-like 114-432 3.1e-45 147.3 In-house 14-226 (295) alignment 
Range on Protein: 114-432
Range on HMM: 14-226/295.0
EHHLSFETKYGVNVSQGNRKYQEDRHKVKMGLEN-NQYLSLFGVFDGHGGDRASNFVKKKIVNCVNKYVKENKAGYSSKnlnssssptgstssasssgss
 ..| . ...||   ||.||..||.. | ..| . .. |.||||||||||..|...... .|. . .....    ...                      
lsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltls.....................

sssasssggggggggplngssssigmphastisptpssgnsstssgasssgvssanspigvgfdspgwmkfnhlynqnnfqqeiqnrSEFLQAALYNTFQ
                                                                                       .| .. ||...|.
.......................................................................................ledieealrkafl

FLDNRYCKKYRQ---KGDGGTTCLVALLSNPpnaqpLLVVANAGDSRGVLCRNGKAYALSYDHKPGNPKEKQRITSSGGKIEWdfneriWRVSGILSVSR
 .|...... ..      .|||..|||. .       |.|||.|||| ||.|||... |..|||| |. |..|| |.|| . .      .|| |.| |.|
aadeellelallrpelagsGtTavvalirgn.....klyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh......grvngvlavtR

GIGDIPLK---------KWVICDPEFVVFPLK
 .|| .||          .|.. |.. |..|.
alGdfdlklllslllleplvsaePdvtvlelt
subfamily_PPM1L_pd Subfamily PPM1L 127-431 2.6e-41 134.6 In-house 11-204 (269) alignment 
Range on Protein: 127-431
Range on HMM: 11-204/269.0
VSQGNRKYQEDRHKVKMGLENNQYLSLFGVFDGHGGDRASNFVKKKIVNCVNKYVKENkagyssK------NLnssssptgstssasssgsssssasssg
  .| |.  ||| ... ...|.   |.|.|||||||. |..|.|...|. . . ..|       .                                   
svlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknkliel......dadkentep...........................

gggggggplngssssigmphastisptpssgnsstssgasssgvssanspigvgfdspgwmkfnhlynqnnfqqeiqnrSEFlQAALYNTFQFLDNRYCK
                                                                                .| .  | .    .|..  .
...............................................................................inf.sklltdeilsvdeklle

KYRQ-KGDGGTTCLVALLSNPPnaqplLVVANAGDSRGVLC-RNGKAYALSYDHKPGNPKEKQRITSSGGKIEwdFNeRIWRVSGILSVSRGIGDIPLK-
| .. .   |||.|.||...       |.||| |||||||. ..|||  ||.|||| ..||..|| ..|| |   |.  .|||.|.|..|| .|| ||| 
kakraediaGttalialvqesd.....livanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfia..fr.GvwrvaGvlatsralGdyplkd

-KWVICDPEFVVFPL
 . || ||. . | |
knlviadpdiltfdl
PP2C Protein phosphatase 2C 286-431 3.8e-32 104.9 Pfam-A 50-198 (255) alignment 
Range on Protein: 286-431
Range on HMM: 50-198/255.0
LYNQNNFQQEIQNRSEFLQA-----ALYNTFQF-LDNRYCK-KYR-QKGDGGTTCLVALLSNPPnaqplLVVANAGDSRGVLCRNGKAY-ALSYDHKPGN
 | ... .. ......||..     ||...|.  .|..  . | . .  . |.|..|||...       | |||.|||| ||||...|. .|..|||| .
kyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksGstavvalirgkk.....lyvAnvGDSravLcrkdnakkeltedHkpsd

PKEKQRITSSGGKIEWdfnerIWRVSGILSVSRGIGDIPLKK----WVICDPEFVVFPL
..|..||...||....     ..|| | |.||| .||  ||.    .|...|.  ...|
edEreRIeeaggsvsn.....ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvkl
PP2C Protein phosphatase 2C 286-431 3.8e-32 104.9 In-house 50-198 (255) alignment 
Range on Protein: 286-431
Range on HMM: 50-198/255.0
LYNQNNFQQEIQNRSEFLQA-----ALYNTFQF-LDNRYCK-KYR-QKGDGGTTCLVALLSNPPnaqplLVVANAGDSRGVLCRNGKAY-ALSYDHKPGN
 | ... .. ......||..     ||...|.  .|..  . | . .  . |.|..|||...       | |||.|||| ||||...|. .|..|||| .
kyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksGstavvalirgkk.....lyvAnvGDSravLcrkdnakkeltedHkpsd

PKEKQRITSSGGKIEWdfnerIWRVSGILSVSRGIGDIPLKK----WVICDPEFVVFPL
..|..||...||....     ..|| | |.||| .||  ||.    .|...|.  ...|
edEreRIeeaggsvsn.....ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvkl
0049733 PP2C-like 122-431 6.1e-32 103.9 In-house 4-175 (235) alignment 
Range on Protein: 122-431
Range on HMM: 4-175/235.0
KYGVNVSQGN-RKYQEDRHKVkmglennqYLSLFGVFDGHGGDRASNFVKKKIVNCVNKYVKEnkagY---Ssknlnssssptgstssasssgsssssas
..|.   .|. ||..||.. |         |.||.|.||||| .|.... . .|... ....|    .   .                            
svgaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllellle....lllld............................

ssggggggggplngssssigmphastisptpssgnsstssgasssgvssanspigvgfdspgwmkfnhlynqnnfqqeiqnrsefLQAALYNTFQFLDNR
                                                                                     |..||...|. ....
.....................................................................................leealrkaflaanea

YCKKYRQ---KGDGGTTCLVALLSnppnaQPLLVVANAGDSRGVLCRNGKAYALSYDHKPGNPKEKQRITSSGGKIewdfneriwRVSGILSVSRGIGDI
.......      .|||..||||      .  |.|||.|||| .|.|.||.. |..||.| |. |.|||.. || .         || |.| ..| .|| 
llelalaspelagmgtTavvalld.....ggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav.........rvpgrlaltralGdl

PLKkwvicdPEFVVFPL
.||      |...|..|
llk......pdvtvlel
PPM_PTC7 286-429 4.7e-31 101.1 In-house 50-201 (259) alignment 
Range on Protein: 286-429
Range on HMM: 50-201/259.0
LYNQNNFQQEIQNRSEFLQA-----ALYNTFQFLDNRYCKKY---R-QKGDGGTTCLVALLSNPPnaqplLVVANAGDSRGVLCRNGKAY-ALSYDHKPG
 | .... . ...|..| .      ||...|. || .. .|    . .. ..|.|..|||...       | |||.|||| ||||.|.|. .|..|||| 
kyarehleeilkerksfeeleklekalrksflaldtdeelksseantepstsGstAvvalitgsk.....lyvAnvGDSravLcrsgnavkqltedHkps

NPKEKQRITSSGGKIEWDfneRIWRVSGILSVSRGIGDIPLKK------WVICDPEFVVF
|..|..||...||.....   . .|| | | ||| .||  ||.      .|...|.  . 
nedEreRiegaggsvsnv...gngrvngvlavsRafGdfelkpketeeqlvsaePdisst
subfamily_PPM1E_pd Subfamily PPM1E 285-433 9.9e-30 96.6 In-house 61-199 (265) alignment 
Range on Protein: 285-433
Range on HMM: 61-199/265.0
HLYNQNNFQQEIQNRSEflqAALYNTFQFLDNRYCKK-YRQKGDGGTTCLVALLSNPPnaqplLVVANAGDSRGVLCRNGKAYALSYDHKPGNPKEKQRI
||...   |..... ..    || ..|. .|.|...|  |.|  .|.|  |.|...       | ||  |||...|.|.|.|  |   ||| ...||.||
hlhellvrqeklkedpa...ealkeafkltDerflqkaereklksGstavvvliekdq.....lyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRi

TSSGGKIEWDfneRIWRVSGILSVSRGIGDIPLKKWVICDPEFVVFPLKG
 . || . .      ||| |.||||| |||  ||..|. ..... ..|.|
eeagGlvvvi...gawRvnGvLsvsRaiGDvklkpyvsgeadvaeveldg
Subfamily Dicty-PPM1L-like 573-642 4.9e-28 90.8 In-house 235-304 (305) alignment 
Range on Protein: 573-642
Range on HMM: 235-304/305.0
VDQFFVLATDGIWDVFENQELVEFINAIIEESYHSKRLDWDPNEISKRVVQEAYRKGSGDNATVLIIKLY
 |||.||||||.|.|...|..||............|...||.||||...|.||...|||||.|..||||.
nDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgDnitlviiklk
subfamily_PPM1A_pd Subfamily PPM1A 287-418 8.7e-27 87.2 In-house 69-194 (282) alignment 
Range on Protein: 287-418
Range on HMM: 69-194/282.0
YNQNNFQ--QEIQNRSEFLQAALYNTFQFLDNRYCKKYRQK---GDGGTTCLVALLSnppnaQPLLVVANAGDSRGVLCRNGKAYALSYDHKPGNPKEKQ
 ......  .. .. .. .. || . |  ||..  .. ...      |.|....|.|     .  |..||.||||.||||||||  |..|||| .||||.
leeeelkeaaleasekdevkealrqgfLaldeairelstdlktadksGsTavtvlvs.....ekhliianlGDsRavlcrngkaaflteDHkpsrpkEkk

RITSSGGKIEwdfnerIWRVSGILSVSRGIGDIPLKK
||.  ||..       . || | | ||| .||  .|.
RieqAGGsvv......vsRvnGaLAvsRalGDyeyke
subfamily_PPM1K_pd Subfamily PPM1K 294-425 1.5e-25 82.8 In-house 58-191 (263) alignment 
Range on Protein: 294-425
Range on HMM: 58-191/263.0
QEIQNRSEFLQAALYNTFQFLDNRYCKKYR------QKGDGGTTCLVALLSNPPNaqplLVVANAGDSRGVLCRNGKAYALSYDHKPGNPKEKQRITSSG
... .. . |.  | |.|. ||... .  .      ..   |||  |.|| .  .    ||.|. |||| .|||||||  |. ||.|   .||.|| ..|
krllekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGte....lvlaslGdsrailcrnGkakkltrdhdPeleeekerikaag

GKIEWDFNERIwRVSGILSVSRGIGDIPLKKW-VICDPE
|..||.  ..  .| | |...| .||. ||.. || .||
Gsvewnslgkp.lvngrlamtrslGdldlkryGviatPe
subfamily_PPM1G2_pd Subfamily PPM1G2 287-425 7.7e-25 80.4 In-house 69-201 (287) alignment 
Range on Protein: 287-425
Range on HMM: 69-201/287.0
YNQNNFQQEIQNRSEF----LQAALYNTFQFLDNRYCKK-YRQKGDGGTTCLVALLSNPPnaqplLVVANAGDSRGVLCRNGKAYALSYDHKPGNPKEKQ
|  ..... |.....|    |. .| ..|  .|.   |.   .. . |.|..|.|...       |.|||||||| ||. .|.. |||.|||| . .||.
yagkklikkiakkksfkegaleqilkdafletDeellkdeklkdesaGstavvvlikeek.....lyvanaGDsravlsskgnvkalsfDhkPqeesekk

RITSSGGKIEWDfneriwRVSGILSVSRGIGDIPLKKWVICDPE
||. .|| .| .      ||.| |..|| .||   || |   ||
riiaagGfveln......rvngnLalsralgDfefkknvkkkpe
subfamily_PPM1G_pd Subfamily PPM1G 326-418 8.8e-25 80.6 In-house 294-376 (473) alignment 
Range on Protein: 326-418
Range on HMM: 294-376/473.0
GDGGTTCLVALLSNppnaqPLLVVANAGDSRGVLCRNGKAYALSYDHKPGNPKEKQRITSSGGKIEWDFneriwRVSGILSVSRGIGDIPLKK
 | |||  |||| .       |.|||||||| ||.|||||  ||.|||| ...|..||   |||.. |      || | | .|| .||   ||
edsGttAvvaLlke.....kklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedg.....RvnGGLnlsRAlGDhaYkk
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 329-426 1.1e-21 70.2 In-house 96-187 (255) alignment 
Range on Protein: 329-426
Range on HMM: 96-187/255.0
GTTCLVALLSNppnaqPLLVVANAGDSRGVLC-RNGKAYALSYDHKPGNPKEKQRITSSGGKIEWDfnERIWRVSGILSVSRGIGDIPLKKWVICDPEF
|||  ..|. .        ..|| |||| ||| ..| |  ||.|||| ...|..||.  ||..  .      || | |.||| .||. |. .|. ||..
Gttaasvliie.....dkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvst..vvtsrvnGtlavsralGdsflePfvvpdPdl
subfamily_PP2D1_pd Subfamily PP2D1 346-429 8.9e-20 63.8 In-house 189-273 (492) alignment 
Range on Protein: 346-429
Range on HMM: 189-273/492.0
LLVVANAGDSRGVLCRNGKAYALSYDHKPGNPKEKQRITSSGGKIEwdFNERIWRVSGILSVSRGI---GDIPLKKWVICDPEFVVF
.| .||||. . ||||.|||. |  .| |.|.||..|.. .|. .    .|.  .| |||.. ||.   ||  ||| ||..|..   
vlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvv..kseknglvnGildttRGLGnyGdpkLkksvipePkttsv
subfamily_PPM1A_pd Subfamily PPM1A 570-642 1.7e-17 56.7 In-house 216-281 (282) alignment 
Range on Protein: 570-642
Range on HMM: 216-281/282.0
YGEVDQFFVLATDGIWDVFENQELVEFINAIIEESYHSKRLdwdpneiSKRVVQEAYRKGSGDNATVLIIKLY
  | |.|.||| |||||| ...|.||...  .| ... ...       .|..|..|..|||.|| .||.. . 
rseeddflvlacDGiwDvlsdeevvelvrkrlevadeleev.......akalvdkalekgsrDNlsvlvvlfa
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 303-428 3.4e-17 55.9 In-house 59-198 (292) alignment 
Range on Protein: 303-428
Range on HMM: 59-198/292.0
LQAALYNTFQFLDNRYCKKYRQKGDGGTTCLVALLSnpPNA-QplLVVANAGDSRGVLCR-----NGKAYALSYDHKPGNPKEKQRITSSGGKIE-----
|  || .    .  .. | . ...  .||. |      ..  .  |..|| |||| .| |     . .   || |||| .| |..||  .||..|     
lsealllrildiaakldkltidaresattavvcarv..rddra..lilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvr

-WDF--NERIWRV---SGILSVSRGIGDIPLKK-WVICDPEFVV
 | |    |.||     | |..|| .||. |..  |...||. .
gwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaePelqi
0034914 PP2C-like 568-641 5.2e-17 54.8 In-house 223-290 (295) alignment 
Range on Protein: 568-641
Range on HMM: 223-290/295.0
YNYG-EVDQFFVLATDGIWDVFENQELVEFINAIIEEsyhskrlDWDPNEISKRVVQEAYRKGSGDNATVLIIKL
.... | |.|..||.||.|||..|.|.|....  ...        .|..|.....|..|...|| || ||....|
leltledddfllLasDGlwdvlsneeivdivrsllak.......gldleeaaeeLvdlAlargsrDNiTvvvvrl
PP2Cc_SM00332 571-639 6.9e-17 54.7 In-house 210-274 (274) alignment 
Range on Protein: 571-639
Range on HMM: 210-274/274.0
GEVDQFFVLATDGIWDVFENQELVEFINAIIEESyhskrLDWDPNEISKRVVQEAYRK-GSGDNATVLII
 . |.|..||.||.|||..|||.|.........       . || |.......||.|. || || ||...
tsedeflilaSDGlwdvlsnqevvdivrkllakg.....ktndpqeaaelldeeairrggseDniTvvvv
PP2C Protein phosphatase 2C 567-633 2.6e-15 49.7 Pfam-A 197-254 (255) alignment 
Range on Protein: 567-633
Range on HMM: 197-254/255.0
QYNYGevDQFFVLATDGIWDVFENQELVEFINAIIEESYhskrldwDPNEISKRVVQEAYRKGSGDN
. ..   |.|..||.||.|||...||.|....  ... .       .|.|.....|.||...|| ||
kltee..defliLasdGlwdvlsdqeavdlvrselskkk.......spmeaaeelvdeaiargsedn
PP2C Protein phosphatase 2C 567-633 2.6e-15 49.7 In-house 197-254 (255) alignment 
Range on Protein: 567-633
Range on HMM: 197-254/255.0
QYNYGevDQFFVLATDGIWDVFENQELVEFINAIIEESYhskrldwDPNEISKRVVQEAYRKGSGDN
. ..   |.|..||.||.|||...||.|....  ... .       .|.|.....|.||...|| ||
kltee..defliLasdGlwdvlsdqeavdlvrselskkk.......spmeaaeelvdeaiargsedn
subfamily_ILKAP_pd Subfamily ILKAP 293-425 4.4e-15 48.6 In-house 75-206 (293) alignment 
Range on Protein: 293-425
Range on HMM: 75-206/293.0
QQEIQNRSEFLQAALYNTFQFLDNRYCKKYRQK----GDGGTTCLVALLSNppnaqpLLVVANAGDSRGVLCRNGKAY------ALSYDHKPGNPKEKQR
....... . .. .| ..|.  |. . |. ...     || |. .|  | |      .| ||| |||. ||.|. ..       .|. ||.| . .|..|
ksdvsakekeikkclvdsfkktdeefLklaskakPvWkdGstatvvlvldn......vlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkr

ITSSGGKIEwdfNEriwRVSGILSVSRGIGDIPLKKW-VICDPE
|  .||...   .    || |.| ||| |||   |.  ||. |.
iqkaGgvvr...dg...rvlGvlevsrsiGdgrfkrlGvistPd
0049733 PP2C-like 567-641 1.2e-14 47.5 In-house 172-233 (235) alignment 
Range on Protein: 567-641
Range on HMM: 172-233/235.0
QYNYGEVDqFFVLATDGIWDVFENQELVEFINAiieesyhskrldWDPNEISKRVVQEAYRKGSGDNATVLIIKL
.... . | |..||.||.|||....|.|....              |..|. .|.|..|...|. || ||....|
vlelepgd.flllasDGlwdvlsdeeivdllrs............ldleeaaerlvelalarggrDNiTvvvvrl
subfamily_PPM1A_pd Subfamily PPM1A 120-182 2e-14 46.6 In-house 11-75 (282) alignment 
Range on Protein: 120-182
Range on HMM: 11-75/282.0
ETKYGVNVSQGNRKYQEDRHKVKMGLENNQYLSLFGVFDGHGGDRASNFVKKKIVNCVNKY--VK
. .|||.  || |.  ||.|.| . |.. .  |.| |||||.|......|||.... . .   .|
glrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelk
PPM_PTC7 572-633 3.4e-14 45.9 In-house 206-258 (259) alignment 
Range on Protein: 572-633
Range on HMM: 206-258/259.0
EvDQFFVLATDGIWDVFENQELVEFINAIIEESyhskrldwDPNEISKRVVQEAYRKGSGDN
| |.|..||.||.|||...||.|....  ...         ||.|.....|.||...|| ||
e.defliLasdGlwdvvsdqeavdlvrselskk........dpmeaaeklvdeaiargsedn
subfamily_KAPP-like_pd Subfamily KAPP-like 304-418 4.9e-14 45.0 In-house 80-184 (266) alignment 
Range on Protein: 304-418
Range on HMM: 80-184/266.0
QAALYNTFQFLDNRYcKKYRQKGDGGTTCLVALLSnppnAQPLLVVANAGDSRGVLCRNGKAYALSYDHKPGNPKEKQRITSSGGKIewdfNERIWRVSG
.  | |.|. .|..  |..  .|   | .||         | .| ||| |||   |.|  ..  ||.|||  .|.|||||   |  .     .   |. |
skllenafkevdakl.kdfeyeGatatlalvwsdG....qqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitl....sdnqtrinG

IlSVSRGIGDIPLKK
.  ||| .||  .|.
l.avsralGdhfike
PPM_PTC7_motif 578-633 6.5e-14 45.2 In-house 1-50 (51) alignment 
Range on Protein: 578-633
Range on HMM: 1-50/51.0
VLATDGIWDVFENQELVEFINAIIEESYHskrldwDPNEISKRVVQEAYRKGSGDN
.||.||.|||...||.|....  ... .       .|.|.....|.||  .|| ||
iLAsDGLWDvlsdqeavdlvrdqlskkgl......spqeaAeklvdealargseDn
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 289-418 2.9e-13 42.3 In-house 73-194 (276) alignment 
Range on Protein: 289-418
Range on HMM: 73-194/276.0
QNNFQQEIQNRSEFlqaaLYNTFQFLDNRYcKKYRQKGDGGTTCLVALLS--NPPNAQPLLVVANAGDSRGVLCRNGKAYALSYDHKPGNPKEKQRITSS
|..  ..| ..|.     | . |. .|..  |..  .|   | .||      .  . |  | ||| |||   |.|  ..  ||.|||  .|.|||||   
qddGGdniydqskl....lldlfkevdakl.kdfeyeGatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikdd

GGKIewdfNERIWRVSGIlSVSRGIGDIPLKK
|  .     .   |. |.  ||| .||  .|.
Gitl....sdnqtrinGl.avsralGdhfike
subfamily_PPM1G_pd Subfamily PPM1G 118-180 1e-12 40.8 In-house 16-76 (473) alignment 
Range on Protein: 118-180
Range on HMM: 16-76/473.0
SFETKYGVNVSQGNRKYQEDRHKVKMGLENNqyLSLFGVFDGHGGDRASNFVKKKIVNCVNKY
. |..||.   || |. ||| |.. . |...   |||.|.|||||   ...| ||. ..... 
neelsygasamqGwrvsqEDahncitdlded..tslfavyDGHGGkevakyvakklpdllkaq
subfamily_ILKAP_pd Subfamily ILKAP 570-641 1.9e-12 40.0 In-house 212-292 (293) alignment 
Range on Protein: 570-641
Range on HMM: 212-292/293.0
YGEVDQFFVLATDGIWDVFENQELVEFINAIIEESYHSKRLDWDPNE---------ISKRVVQEAYRKGSGDNATVLIIKL
 .| |.| ||| ||.|.||...| |.||....|. ....... ....         ...|. .|| ..||.|| |||..|.
LtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllvki
subfamily_PPM1E_pd Subfamily PPM1E 569-639 3.8e-12 38.9 In-house 196-260 (265) alignment 
Range on Protein: 569-639
Range on HMM: 196-260/265.0
NYGEVDQFFVLATDGIWDVFENQELVEFINAIIEESYHskrldwDPNEISKRVVQEAYRKGSGDNATVLII
.  . ... .||.||.|||....|.|. ... .... .      | .|..| .|..|. .|| || ||...
eldgseeylilacDGlwDvvneeevvklveefladgae......dlsevakllveaakeagssDnitvvvv
PPM_PTC7_SpoIIE 303-418 7.8e-12 38.5 In-house 69-162 (230) alignment 
Range on Protein: 303-418
Range on HMM: 69-162/230.0
LQAALYNTFQFLDNRYCKKyrqKGDGGTTCLVALLSNPPnaqPLLVVANAGDSRGVLCRN-GKayalsydhkpgnpkEKQRItSSGGKIEwD-F-NEriw
. ..|..... |. .. ..    ...|.|..|||. .       | |||||||. .|.|. |.              |. ||  .|| ..   . ..   
peeilrrlnlalaadlede...psssgaTavvalidpst...gklyvanaGdsppllvrddgg..............ereri.vagglps.lGilpg...

RVSGILSVSRGIGDIPLKK
|| | |.||. .||. |. 
rvfgvlavslapGdlllly
subfamily_PPM1L_pd Subfamily PPM1L 574-641 4.1e-11 35.6 In-house 209-266 (269) alignment 
Range on Protein: 574-641
Range on HMM: 209-266/269.0
DQFFVLATDGIWDVFENQELVEFINAIIEEsyhskrldwdPNEISKRVVQEAYRKGSGDNATVLIIKL
 .|..||.||.|| | |.| |.||   ..|          |.  .| .| |....|| || |||..||
peflilasdGlwdtfsneeavrfikerlke..........pdfGakslvlesfkrGsvdnitvlvvkl
subfamily_PPM1H_pd Subfamily PPM1H 288-383 1.1e-10 33.8 In-house 121-210 (404) alignment 
Range on Protein: 288-383
Range on HMM: 121-210/404.0
NQNNFQQEIQNRSEFLQAALYNTFQFLDNRYCKKYR-QKGDGGTTCLVALLsnppnAQPLLVVANAGDSRGVLCRNGKAYALSYDHKPGNpkEKQRI
 .. ....  .. | .  || . |. .|.   .  .  .  || | ||||.      .  | |||||||| .|.|...  .|| |. |    |.||.
vseiyeekeiskeeLviGalesaflemDeqiarereayrikGGCtalvalv.....llgklYvanaGDsRailvrkdeiiplsadftPet..eRqRl
subfamily_PPM1D_pd Subfamily PPM1D 125-179 1.4e-10 33.8 In-house 6-63 (309) alignment 
Range on Protein: 125-179
Range on HMM: 6-63/309.0
VNVSQGNRKYQEDRHKVKMGLENNQ---YLSLFGVFDGHGGDRASNFVKKKIVNCVNK
.. .||.||| ||. ....  |...     . ..|||||||  |..|....... ..|
seadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikk
subfamily_PPM1G2_pd Subfamily PPM1G2 120-191 1.7e-10 33.3 In-house 18-87 (287) alignment 
Range on Protein: 120-191
Range on HMM: 18-87/287.0
ETKYGVNVSQGNRKYQEDRHKV---KMGLENNQYLSLFGVFDGHGGDRASNFVKKKIVNCVNKyvkenKAGYSSK
 || |    || |  .|| | .    . ..... |.||.|||||||....... ||... ..|     |  ... 
ltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak.....kksfkeg
subfamily_PPM1G2_pd Subfamily PPM1G2 572-641 3.2e-10 32.4 In-house 218-286 (287) alignment 
Range on Protein: 572-641
Range on HMM: 218-286/287.0
EVDQFFVLATDGIWDVFENQELVEFINAIIEESyhsKrldwDPNEISKRVVQEAYRKGS------GDNATVLIIKL
| | | ||| ||||||..|.|.|....  . .    .    ...||........  . |       || ||.|. |
eddeflvLaCDGiWDvltnkevvdlvrerlvsg...a....kldeiieelldkclapdssntgvGcDnmtvvivvl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 568-641 4.8e-10 32.1 In-house 191-253 (255) alignment 
Range on Protein: 568-641
Range on HMM: 191-253/255.0
YNYGEVDQFFVLATDGIWDVFENQELVEFINAIIeesyhskrldwDPNEISKRVVQEAYRKGSGDNATVLIIKL
..  . |.|..|| |||||.  ..| || . .|            ||.. ....   || .|| || .|..|||
leiskkdkflilacdGiwdlisdeeaveivagis...........dpekaaeklrdlayssGstdnisvivikl
subfamily_PPM1K_pd Subfamily PPM1K 124-184 1.5e-09 30.4 In-house 7-64 (263) alignment 
Range on Protein: 124-184
Range on HMM: 7-64/263.0
GVNVSQGNRKYQEDRHKVKMgLENNqyLSLFGVFDGHGGDRASNFVKKKIVNCVNKYVKEN
|..  .| |.  ||| |.|  |...  |  ..|||||.|  | .|| .|. ...... ...
GkdsliGkraenedriklke.ldpe..llyvavfdGhaGsaaadfvhdklekilkrlleke
subfamily_PDP_pd Subfamily PDP 567-624 3e-09 29.5 In-house 278-335 (398) alignment 
Range on Protein: 567-624
Range on HMM: 278-335/398.0
QYNYGEVDQFFVLATDGIWDVFENQELVEFINAIIEESYHSKRLDWDPNEISKRVVQE
... .| |.|.||||||.||...|.| |. ..  .... ... .  ........ |.|
shklrendkFLvlatDGLwdllsneevvslVgehlakkkekepvkveeakltlkqvve
subfamily_PPM1G_pd Subfamily PPM1G 572-640 3.1e-09 29.4 In-house 400-469 (473) alignment 
Range on Protein: 572-640
Range on HMM: 400-469/473.0
EVDQFFVLATDGIWDVFENQELVEFINAIIEESYHSKRLDWDPNEISKRVVQEAYRKGSG-DNATVLIIK
| |.|.|||.||||.| | || |.|..| .... .|.  .   . . . ....    |.| || ||.|. 
eedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivl
subfamily_PPM1D_pd Subfamily PPM1D 323-392 5.8e-09 28.4 In-house 103-173 (309) alignment 
Range on Protein: 323-392
Range on HMM: 103-173/309.0
RQKGDGGTTCLVALLSNppnaqPLLVVANAGDSRGVLCRNGK------AYALSYDHKPGNPKEKQRITSSGGKIEW
 .    |||. | .. .       | ||. |||. ||  . .      |  |  |||| .|.||.|| ..||..  
gllstaGttasvviirr.....eklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaa
subfamily_TAB1_pd Subfamily TAB1 319-416 7.1e-09 27.9 In-house 120-212 (333) alignment 
Range on Protein: 319-416
Range on HMM: 120-212/333.0
CKKYRQKGDGGTTCLVALLSNppNAqplLVVANAGDSRGVLCR---NGKAYALSYDHKPGNPKEKQRITSSGGKIEWdfNERIWRVsGILSVSRGIGDIP
 ..  ..  |||| .|||. |  |    | |||.|||| .|..   . |   || ||.  |..| .|.   |  ||    .|  |. |     | |||  
lqeleeeisgGttAvvalifn..nk...LyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieq..ikrnkrl.gskentRsiGdyk

L
.
v
subfamily_PDP_pd Subfamily PDP 135-191 2.7e-08 26.3 In-house 11-65 (398) alignment 
Range on Protein: 135-191
Range on HMM: 11-65/398.0
QEDRHKVKMGLENNqyLSLFGVFDGHGGDRASNFVKKKIVNCVNKYVKENKAGYSSK
 |||. .   ||.|  . ||||||||||  ... |.|.... |.. . ...   ...
iEDrrseakllesn..gvlfgvfDGHggaacaeavskrLlkyvaasllkkqvleeae
subfamily_PDP_pd Subfamily PDP 290-417 3e-08 26.2 In-house 102-241 (398) alignment 
Range on Protein: 290-417
Range on HMM: 102-241/398.0
NNFQQEIQNRSEFLQAALYNTFQFLDNRY------------CKKYRQKGDGGTTCLVALLSNPPnaqplLVVANAGDSRGVLCRN---G--KAYALSYDH
...|. .. . | .. || ..|. ||.               ..  ...  |...|.||...       | |||.||.| ||...   |  .| .|| |.
kylqelleaevekvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegte.....lhvAntGDcravlgvqeeegsweavkLskdq

KPGNPKEKQRITSSGGKIEWDFNERIWRVSGILSVSRGIGDIPLK
   |..| .|| .   . |     |  |. | |  .|  ||. .|
tadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryK
PPM_PTC7 122-179 5e-08 25.7 In-house 2-62 (259) alignment 
Range on Protein: 122-179
Range on HMM: 2-62/259.0
KYGVNVSQGNRKYQEDRHKVKMGLE---NNQYLSLFGVFDGHGGDRASNFVKKKIVNCVNK
..|..  || ||  ||.| .. .||    ... ..|.|||||||..|........ .....
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilke
PPM_PTC7_SpoIIE_motif 577-641 5.5e-08 26.4 In-house 15-80 (81) alignment 
Range on Protein: 577-641
Range on HMM: 15-80/81.0
FVLATDGIW-------DVFENQELVefinAIIEESyHSKRldwdPNEISKRVVQEAYRKG---SGDNATVLIIKL
..|.|||..       ..|...||.    .....  ..|.    . |.....|.|. . |   . |..|.|....
llLyTDGltEardsdgelfgkeell....rladra.egks....lqeladklvdevlengsgereDDitllvlrv
PP2C_SIG_SM00331 572-641 9.1e-08 24.9 In-house 149-217 (217) alignment 
Range on Protein: 572-641
Range on HMM: 149-217/217.0
EvDQFFVLATDGIWDV-----FENQELVEFINAIIeeSYHSKRLDWdpnEISKRVVQEAYRKGSGDNATVLIIKL
. . ...|.|||....     |....| |.. .    . ....|.    .| ......| ...  |..||...|.
k.gdllllytDGltearsekgfaeerleeiledlv..dseaqelaq...kiveellelakgsngeDdiTvvvvkv
subfamily_PPM1E_pd Subfamily PPM1E 125-179 2e-07 23.5 In-house 8-68 (265) alignment 
Range on Protein: 125-179
Range on HMM: 8-68/265.0
VNVSQGNRKYQEDRHKVK------MGLENNQYLSLFGVFDGHGGDRASNFVKKKIVNCVNK
..  ...|. .|||| .       ..|....  . |.|||||||  |... .... . . .
iaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvr
PP2C Protein phosphatase 2C 122-186 4.6e-07 22.7 Pfam-A 2-69 (255) alignment 
Range on Protein: 122-186
Range on HMM: 2-69/255.0
KYGVNVSQGNRKYQEDRHKVKMGLE---NNQYLSLFGVFDGHGGDRASNFVKKKIVNCVNKYVKENKA
..|..  || ||  ||.|     ||    ..  ..|.|||||||..|... .... .....  . ...
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflel
PP2C Protein phosphatase 2C 122-186 4.6e-07 22.7 In-house 2-69 (255) alignment 
Range on Protein: 122-186
Range on HMM: 2-69/255.0
KYGVNVSQGNRKYQEDRHKVKMGLE---NNQYLSLFGVFDGHGGDRASNFVKKKIVNCVNKYVKENKA
..|..  || ||  ||.|     ||    ..  ..|.|||||||..|... .... .....  . ...
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflel
subfamily_ILKAP_pd Subfamily ILKAP 129-184 5.2e-07 22.1 In-house 13-76 (293) alignment 
Range on Protein: 129-184
Range on HMM: 13-76/293.0
QGNRKYQEDRHKVKMGLEN------N--QYLSLFGVFDGHGGDRASNFVKKKIVNCVNKYVKEN
.|.|.  .| | .   |..      .  . .| ..|||||.|.|||.|...|. . . . . ..
kGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpks
subfamily_PPM1K_pd Subfamily PPM1K 573-641 6.1e-07 21.8 In-house 201-258 (263) alignment 
Range on Protein: 573-641
Range on HMM: 201-258/263.0
VDQFFVLATDGIWDVFENQELVEFINAIieesyHskrldwDPNEISKRVVQEAYRKGSGDNATVLIIKL
 | |.|| |||| .| ..||| ....       |      ||.| .. ... | . || ||||.... |
adsflvlitdgisfvvnsqelcdlvrlc.....h......dpeeaahalteqalqygsednatavvvpl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 128-186 2.4e-06 20.0 In-house 13-71 (255) alignment 
Range on Protein: 128-186
Range on HMM: 13-71/255.0
SQGNRKYQEDRHKVKMGLENNQYLSLFGVFDGHGGDRASNFVKKKIVNCVNKYVKENKA
  | |   ||.  .    ....   .. .||||||..|..|  ... . ...... |.|
miGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnna
subfamily_PPM1D_pd Subfamily PPM1D 571-640 2.7e-06 19.7 In-house 235-306 (309) alignment 
Range on Protein: 571-640
Range on HMM: 235-306/309.0
GEVDQFFVLATDGIWDVFENQELVEFINAIIEESYHSKRLDwdpNEISKRVVQEAYRKGSG-----DNATVLIIK
.. ..| .||.||.|.| . .. |....   | ..  .  .   ....|..|.||  . .      || .|... 
pneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs...rsvakalvkealqrwrskklraDnvsvivvi
subfamily_TAB1_pd Subfamily TAB1 134-174 6e-06 18.3 In-house 13-50 (333) alignment 
Range on Protein: 134-174
Range on HMM: 13-50/333.0
YQEDRhKVKMGLENNQYlsLFGVFDGHGGDRASNFVKKKIV
..||.   ..  ||...  |..||||. |..|..||....|
evedk.vflfktendpi..lyavFdGydGnkaakfveqrLv
Nbl1_Borealin_N Nbl1 / Borealin N terminal 290-318 6.4e-06 12.0 Pfam-A 8-36 (59) alignment 
Range on Protein: 290-318
Range on HMM: 8-36/59.0
NNFQQEIQNRSEFLQAALYNTFQFLDNRY
.||..|...| |.| . . |. . |..|.
qnfdlEveeRierlrshyenllkklrarl