Gene DDB_G0290075 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP106_AA protein Get Run
DdisP106_AA_249-535 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 251-535 1.9e-49 161.1 In-house 14-287 (295) alignment 
Range on Protein: 251-535
Range on HMM: 14-287/295.0
EEEEILDLNYSGNTVLGTRDENQDTFFQKN---FKSEGIRVIGVFDGHGdeGMDASATTRDIISKIVEKEIVN-SNDNKKSDDFYDKCITSSFLEANEAL
   ..| |.... .. | |..|.| ..      .  |.. ..|||||||  | .|.   .... ... ... .  . .  |.. . ......||.|.|.|
lsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhg..Ghaaaevasellvelllellekllllltlsledieealrkaflaadeel

LEKGKI---TGDWGTTATLAIIKDNHIRVGWVGDSMAVLFkqsANGkdyTPIQLSNDHKPENPLEKKRIITTGGRVVFrcgcyrviPNKNdysnddimkq
||..        .||||..|.|..|.. |..|||| |||.    ||   ...||..|||| |.||..||.. ||.|..        . .|          
lelallrpelagsGtTavvalirgnklyvanvGDSravll...rng...elvqltvdhkpvnelererilsaggavsh........grvn..........

rLALNMSRALGHVVLS--------KYGVSSTPEFQSESL--NPGDYVIVASDGLWNVLDFKACCKYIKK----STSVKELTDLLLSVVESkcqsfKIPCD
   |...||||.. |         ...||..|.... .|  ...|....||||||.||. . .......    .....|. . |.  . .     .  .|
.gvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla.....rgsrD

NVTICC
|.|...
NiTvvv
PP2Cc_SM00332 250-535 1.4e-43 142.3 In-house 2-273 (274) alignment 
Range on Protein: 250-535
Range on HMM: 2-273/274.0
KEEEEILDLNYSGNTVLGTRDENQDTFFQKNF--KSEGIRVIGVFDGHGdeGMDASATTRDIISKIVEKEIVNSNDNKksDDFYDKCITSSFLEANEALL
.|... |.| |. ..  | |....| .....   ..|.  ..|||||||  | ...  ... . .....|. . .|..  .|   ... ..||...|..|
sesgsnlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhg..Gsevakfvskklpealkeelkkkkdel..eddveealkkaflstdeeil

EKGKITG----DWGTTATLAIIKDNHIRVGWVGDSMAVLFKQSAngkdytPIQLSNDHKPENPLEKKRIITTGGrvvfrcgcyrvipnkndysndDIMKQ
|. .       . |.||..|..|.... | .|||| |||....        .|||.|||||.. |.||| . ||                      ..|.
eeeqskelenalsGstavvallkkedlyvanvGDSravlcrngk......avqlsvdhkpedederkRikkagg.....................vvekg

RL--ALNMSRALGHVVLS------KYGVSSTPEFQSESL-NPGDYVIVASDGLWNVLDFKACCKYIKKST------SVKELTDLLLSVVESKcqsfKIPC
|.   |..|||.| . |       . .....|. . ..| . .. .|.||||||.||. .  .....|        ...|  .||   . ..    .  .
rvngglavsrafGdhflkknkklkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairr....ggse

DNVTICC
||.|...
DniTvvv
0049733 PP2C-like 258-535 8.9e-41 132.7 In-house 3-230 (235) alignment 
Range on Protein: 258-535
Range on HMM: 3-230/235.0
LNYSGNTVLGT-RDENQDTFFQknfkseGIRVIGVFDGHGdeGMDASATTRDIISKIVEKEIVNsndnkKSDDFYDKCITSSFLEANEALLEKGKI---T
|.... .. |  |..|.|...       |. ...|.||||  |. |..  .... ... ... .      .   . ......||.|||||||...     
lsvgaasdigrvrkvneDavlv......glllfavaDGhg..ghaagevasellvetllellle.....lllldleealrkaflaaneallelalaspel

GDWGTTATLAIIKDNHIRVGWVGDSMAVLFKqsangkDYTPIQLSNDHKPENPLEKKRIITTGGRVvfrcgcyrvipnkndysnddimKQRLALNMSRAL
   ||||..|.. .... | .|||| |.|..      | . .||. ||.| |.||..|||| ||.|                           | ..|||
agmgtTavvalldggklyvanvGDsrayllr......dgklvqltedhspvnelerqriitaggav......................rvpgrlaltral

GHVVLSkygvsstPEFQSESLNPGDYVIVASDGLWNVLDFKACCKYIKKsTSVKELTDLLLSVVESkcqsfKIPCDNVTICC
|.  |.       |....  |.|||....||||||.||. .  ...... ....|. . |.. . .     .  .||.|. .
Gdlllk.......pdvtvlelepgdflllasDGlwdvlsdeeivdllrs.ldleeaaerlvelala.....rggrDNiTvvv
PP2C Protein phosphatase 2C 261-508 1.9e-38 125.5 Pfam-A 4-233 (255) alignment 
Range on Protein: 261-508
Range on HMM: 4-233/255.0
SGNTVLGTRDENQDTFFQKN-F----KSEGIRVIGVFDGHGdeGMDASATTRDIISkivekEIVNSNDNKKSDDFYDKCITSSFLE-ANEALLEKGKI--
..... | |... |. .  . .    . . .....||||||  | .|.  .|  .      ||..... ..... ..|.. .|||. ..| |  . .   
gaselqgarksmedahialknlekssgkssvaffavfdghg..greaakyarehle.....eilkeqksflelekvekalrksfladtdeelksskante

TGDWGTTATLAIIKDNHIRVGWVGDSMAVLFKQSANGkdytpIQLSNDHKPENPLEKKRIITTGGRVVFrcgCYRVIPNkndysnddimkqrlaLNMSRA
  . |.||..|.|..... | .||||.|||.... .       .|..||||... |..|| . ||.|     . ||  .               |..|||
psksGstavvalirgkklyvAnvGDSravLcrkdnak.....keltedHkpsdedEreRIeeaggsvsn...ngrvngs...............LavsRa

LGHVVLSK---YGVSSTPEFQSESLNPGD-YVIVASDGLWNVLDFKACCKYIKKSTSVKE
|| . | .   . ||. |. .| .|.. | ..|.||||||.||. . ..  ...  | |.
lGdfelkpkeeqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk
PP2C Protein phosphatase 2C 261-508 1.9e-38 125.5 In-house 4-233 (255) alignment 
Range on Protein: 261-508
Range on HMM: 4-233/255.0
SGNTVLGTRDENQDTFFQKN-F----KSEGIRVIGVFDGHGdeGMDASATTRDIISkivekEIVNSNDNKKSDDFYDKCITSSFLE-ANEALLEKGKI--
..... | |... |. .  . .    . . .....||||||  | .|.  .|  .      ||..... ..... ..|.. .|||. ..| |  . .   
gaselqgarksmedahialknlekssgkssvaffavfdghg..greaakyarehle.....eilkeqksflelekvekalrksfladtdeelksskante

TGDWGTTATLAIIKDNHIRVGWVGDSMAVLFKQSANGkdytpIQLSNDHKPENPLEKKRIITTGGRVVFrcgCYRVIPNkndysnddimkqrlaLNMSRA
  . |.||..|.|..... | .||||.|||.... .       .|..||||... |..|| . ||.|     . ||  .               |..|||
psksGstavvalirgkklyvAnvGDSravLcrkdnak.....keltedHkpsdedEreRIeeaggsvsn...ngrvngs...............LavsRa

LGHVVLSK---YGVSSTPEFQSESLNPGD-YVIVASDGLWNVLDFKACCKYIKKSTSVKE
|| . | .   . ||. |. .| .|.. | ..|.||||||.||. . ..  ...  | |.
lGdfelkpkeeqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk
PPM_PTC7 266-511 7.4e-37 120.2 In-house 9-244 (259) alignment 
Range on Protein: 266-511
Range on HMM: 9-244/259.0
LGTRDENQDTFFQKN-FK----SEGIRVIGVFDGHGdeGMDASATTRDIISkivekEIVNSNDNKKSDDFYDKCITSSFLE--ANEALLEKGKIT--GDW
 | |... |. . .. .      . ... .||||||  |  |.  .| ..      ||....  ..... ..|... |||.  ..| |  . . |   . 
qgfrksmedahialanlesssgkdsvaffavfdghg..greaakyarehle.....eilkerksfeeleklekalrksflaldtdeelksseantepsts

GTTATLAIIKDNHIRVGWVGDSMAVLFKQSANGkdytpIQLSNDHKPENPLEKKRIITTGGRVVFRcGCYRVIPNkndysnddimkqrlaLNMSRALGHV
|.||..|.| .... | .||||.|||...  .       ||..||||.|. |..||   ||.|    |. ||  .               |..|||.| .
GstAvvalitgsklyvAnvGDSravLcrsgnav.....kqltedHkpsnedEreRiegaggsvsnv.gngrvngv...............lavsRafGdf

VLSK-----YGVSSTPEFQSESLNPG-DYVIVASDGLWNVLDFKACCKYIKKSTSVK---ELTD
 | .       ||..|. .|  ...  ...|.||||||.|.. . ..  ...  | |   |...
elkpketeeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskkdpmeaae
subfamily_PPM1D_pd Subfamily PPM1D 277-535 4.9e-36 117.4 In-house 33-304 (309) alignment 
Range on Protein: 277-535
Range on HMM: 33-304/309.0
FqknfkseGIRVIGVFDGHGdeGMDASATTRDI-ISKIVEKEIVNSNDNKKSddfyDKCITSSFLEANEALLEK--------GKITGDWGTTATLAIIKD
        .  ...||||||  | .|.  .|.  .|.| ... . |.....      . | ..||. .||. .|         .     ||||.. ||..
l.......evafvavfDGHG..GkeAakfarehlwsvikkqkkflssepedv....leAireaflatheamkkkleeWpktksgllstaGttasvviirr

NHIRVGWVGDSMAVLFKQSANGKDYTPIQLSNDHKPENPLEKKRIITTGGRVVFRCGCYRVIPNK--NDYSNDDIMKQRLALNMSRALGHV-----VLSK
... |. |||| .|| ..  . |  .. .| .|||||.| ||.|| ..||.|  . | .||. ..   . ... ....   |...|.|| .        .
eklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLavaRslGDlWsynaksge

YGVSSTPEFQSESLNPG--DYVIVASDGLWNVLDFKACCKYIKKSTSVKELT-----DLLLSVVE---SKCQSFKIPCDNVTICC
. ||  |. .   |.|   ...|.|||||||||  ..  . ..|. ..|||.     .    .|.   .. .| |. .|||.. .
fvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnvsviv
subfamily_PPM1A_pd Subfamily PPM1A 250-534 1.1e-32 106.5 In-house 4-276 (282) alignment 
Range on Protein: 250-534
Range on HMM: 4-276/282.0
KEEEEILDLNYSGNTVLGTRDENQDTFF-QKNFKSE-GIRVIGVFDGHGDEGMdASATTRDIISKIVEKE-IVNSNDNKKSDDFYDKCITSSFLEANEAL
|...| ..| |. ... | | |. |..  ......  . .   |||||. . . |. ... ....|.|.| . ... .....| . . . ..||...||.
ksqaegnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsev.akyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeai

LEKGKITG---DWGTTATLAIIKDNHIRVGWVGDSMAVLFKQSangkdyTPIQLSNDHKPENPLEKKRIITTGGRVVfrcgCYRVIPNkndysnddimkq
 |. . .      |.||. ......|. .  .||| |||...       . . |..||||..| |||||   || ||      ||  .            
relstdlktadksGsTavtvlvsekhliianlGDsRavlcrng......kaaflteDHkpsrpkEkkRieqAGGsvv....vsRvnGa............

rlaLNMSRALGHVVLSK--------YGVSSTPEFQS-ESLNPGDYVIVASDGLWNVLDFKACCKYIKKSTSVK-ELTDLLLSVVeSKCQSfKIPCDNVTI
   | .|||||   . .          ||. || .| |  .  |....|.||.| ||. .  .....|. .|. ||. .  ..|  |. . |   ||...
...LAvsRalGDyeykeeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalv.dkale.kgsrDNlsv

C
.
l
subfamily_PPM1L_pd Subfamily PPM1L 260-505 4.3e-31 101.2 In-house 7-237 (269) alignment 
Range on Protein: 260-505
Range on HMM: 7-237/269.0
YSGNTVLGTRDENQDTFFQK-NFK-SEGIRVIGVFDGHGDEgmDASATTRDIISKIVEKEIVNSNDNKKSDD--FYDKCITSSFLEANEALLEKGKITGD
 .  .||| |.. .| |  . . | . |.....|||||| |   |.  ..|...| . ..... . .|.      ..| .|   | ..| |||| | . |
vavysvlGrrprmedrfeieediknktgesffavfdGhGGe..faaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraed

-WGTTATLAIIKDNHIRVGWVGDSMAVLFKQSANgkdytPIQLSNDHKPENPLEKKRIITTGGRVVFRcGCYRVipnkndysnDDImkqrlaLNMSRALG
  |||| .|....... |  ||||  ||. .. .      | || ||||... |.|||  .|| . || |..||           .      | .|||||
iaGttalialvqesdlivanvGdsrGvlydkrGk.....aiplsfdhkpqqvkerkrikkaGGfiafr.Gvwrv.........aGv......latsralG

HVVLSKY-GVSSTPEFQSESL---NPgDYVIVASDGLWNVLDFKACCKYIKKSTS
   | .   | ..|.  .  |   .| ...|.||||||. .  .  ...||.  .
dyplkdknlviadpdiltfdlddhkp.eflilasdGlwdtfsneeavrfikerlk
subfamily_PPM1E_pd Subfamily PPM1E 284-511 1.9e-30 98.9 In-house 38-237 (265) alignment 
Range on Protein: 284-511
Range on HMM: 38-237/265.0
EGIRVIGVFDGHGdeGMDASATT-RDIISKIVEKEIVNSNDNkksddfydKCITSSFLEANEALLEK-GKITGDWGTTATLAIIKDNHIRVGWVGDSMAV
. . . .||||||  |..|.  . . . . .|..| ....          . . ..| ...|..|.|  . .   |.||  ..|. ... |.|.||| |.
keraffavfDGHg..Gveaakyaaahlhellvrqeklkedpa........ealkeafkltDerflqkaereklksGstavvvliekdqlyvaWlGDsqal

LFKQSangkdyTPIQLSNDHKPENPLEKKRIITTGGRVVFRcGCYRVipnkndysNDdimkqrlALNMSRALGHVVLSKYgVSSTPEFQSESLNP-GDYV
| ..       . .|| . ||||.. ||||| ..|| ||.  |..||        |         |..|||.| | | .| ||. ... . .|.   .|.
lvrkg......eavqlmkpHkPeredEkkRieeagGlvvvi.gawRv........nG.......vLsvsRaiGDvklkpy.vsgeadvaeveldgseeyl

IVASDGLWNVLDFKACCKYIKKSTSVKE--LTD
|.|.||||.|.. .  .| .... . ..  |..
ilacDGlwDvvneeevvklveefladgaedlse
subfamily_PPM1G2_pd Subfamily PPM1G2 281-534 1.6e-27 89.2 In-house 47-282 (287) alignment 
Range on Protein: 281-534
Range on HMM: 47-282/287.0
FKSEGIRVIGVFDGHGDEGMDASaTTRDIISKIVEkeivnsnDNKKSDDFYDKCITSSFLEANEALLEKGKITGD-WGTTATLAIIKDNHIRVGWVGDSM
  .. . ...|||||| . .  . .....|.||..        .. ...  ....  .||| .| ||.. |.  .  |.||. ..||.... |. .||| 
sddkslalfavfDGhGGakvaky.agkklikkiak.......kksfkegaleqilkdafletDeellkdeklkdesaGstavvvlikeeklyvanaGDsr

AVLFKQSAnGKdytpiQLSNDHKPENPLEKKRIITTGGRVVFR--CGCYRVIPNKNDYSNDDIMKqrlalnmsralghVVLSKYGVSSTPEFQSESLNPG
||| ...   |     .|| ||||..  |||||| .|| | .   .|   .     |..  .  |             .      |  .|.   ..|.. 
avlsskgn.vk.....alsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvk.............kkpeeqivtavPDvlvkklded

-DYVIVASDGLWNVLDFKACCKYIKKSTSVK----E-LTDLLLSVVESKCQSFKIPCDNVTIC
 .....| ||.|.||  | .......  . .    |  ..|| . .  ....  . |||.|..
deflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvv
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 283-511 3.3e-25 81.8 In-house 33-231 (255) alignment 
Range on Protein: 283-511
Range on HMM: 33-231/255.0
SEGIRVIGVFDGHGdeGMDASATTRDIISKIVeKEIVNSNDNKKsddfyDKCITSSFLEANEALLEKGKITgdwGTTATLAIIKDNHIRVGWVGDSMAVL
 ..  .. .|||||  | .|.  . . . ||. .|... |. .       |... .. | .  . |..|     ||||. ..| .... .  |||| .||
ksdedyyalfdGhg..Graaakfaseelykil.aelldlnnanP.....vkslkkaykeistqiserpkfi...GttaasvliiedkvyianvGdsrvvl

FkqsanGKDYTPIQLSNDHKPENPLEKKRIITTGGRVVFRcgcyrvipnkndysnDDIMKQRLALNMSRALGHVVLSKYGVsSTPEFQ--SESLNPGDYV
       || |  .|| |||| .. |.|||   || ||                     .    | .||||| . |. . | . |...   |  .   ..
c.....qkdgtakrlsldhkPseeseekriselGGtvvst...............vvtsrvnGtlavsralGdsflePfvv.pdPdlsqsleiskkdkfl

IVASDGLWNVLDFKACCKYIKKSTSVKELTD
|.| ||.|...  .  .. . .... .. . 
ilacdGiwdlisdeeaveivagisdpekaae
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 268-492 4.3e-24 78.5 In-house 3-216 (292) alignment 
Range on Protein: 268-492
Range on HMM: 3-216/292.0
TRDENQDTFFQKNFkSEGIRV-IGVFDGHGDEGMDASATTRDIIskivEKEIVNSNDN-K-KSDDFYDKCItSSFLEANEALLEKGKITgdwGTTATLAI
 . |||| |   .  || .     |.|||| .|   .  . | .    |.|....  . .  |. .  . . .   . ..  ..... .   .|... |.
nkkenqdrfllveg.sealtflaavldGhGvnGdkvaqlaedtl....evelleltrqlqelsealllril.diaakldkltidaresa...ttavvcar

IKDN-HIRVGWVGDSMAVLFKqSANGKDYTPIQLSNDHKPENPLEKKRIITTGGRVV---FRCGCYRVIPNKndYsndDIMKQRLALNMSRALGHVVLSK
..|.  . .  |||| |.|..    | || .| ||.|||||.| |..||  .||||     |   .|  .    .      .|   | .||||| . | .
vrddralilanvGdsrallgr.clggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarv..w...rrrqqeGdlalsralGdfhlfe

YGVSSTPEFQSESlnpGDYVIVASDGLWNVLD
 || . ||.|  .   |   .    |||    
aGvvaePelqiha...grqylgrgpglwtrss
subfamily_PPM1K_pd Subfamily PPM1K 263-510 2.9e-21 68.8 In-house 9-235 (263) alignment 
Range on Protein: 263-510
Range on HMM: 9-235/263.0
NTVLGTRDENQDTFFQKNFKSEgIRVIGVFDGHGdeGMDASattrDIISKIVEKEIVNSNdNKKSDdfYDKCITSSFLEANEALLEKGKIT------GDW
.. .| | ||.| .  |... | .  ..|||||.  |  |     | . . .|| . .   .|  |   .. .. .|.| ...|    . .         
dsliGkraenedriklkeldpe.llyvavfdGha..Gsaaa....dfvhdklekilkrll.ekekd..leivlknafeeldkklkrylefsvaeaellss

GTTATLAIIKD-NHIRVGWVGDSMAVLFKqsaNGKdytPIQLSNDHKPENPLEKKRIITTGGRVVFrcgcyrvipnkNdYSNDDIMKQRlaLNMSRALGH
|||||.....| ... .  .||| |.| .   |||   . .|..||.||   ||.|| ..||.| .           |  ..   .  |  | |.|.|| 
GttatvsllrdGtelvlaslGdsrailcr...nGk...akkltrdhdPeleeekerikaagGsvew...........n.slgkplvngr..lamtrslGd

VVLSKYGVSSTPEFQSESL--NPGDYVIVASDGLWNVLDFKACCKYIKKSTSVKELT
. | .||| .||| .|  .  .   .... .||. .|.. .  |..... .  .| .
ldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrlchdpeeaa
subfamily_ILKAP_pd Subfamily ILKAP 287-419 3.6e-17 55.4 In-house 44-176 (293) alignment 
Range on Protein: 287-419
Range on HMM: 44-176/293.0
RVIGVFDGHGdeGMDASATTRDIISKIVEKEIVNsNDNKKSDDFYDKCITSSFLEANEALLEKG-KITGDW--GTTATLAIIKDNHIRVGWVGDSMAVLF
   .|||||.  |  ||  . . . | . ... . .| .. .    ||.. || . .| .|..  | .  |  |.|||. .. || . |. .||| ||| 
syyavfdGha..Gsrasefaaeklhkkileklpk.sdvsakekeikkclvdsfkktdeefLklaskakPvWkdGstatvvlvldnvlyvanlGdskavlv

KQSANGKDYTPIQLSNDHKPENPLEKKRIITTGGRV
... .|. .. ..|. ||.| .  |.|||  .|| |
rkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvv
PPM_PTC7_SpoIIE 286-505 2.7e-16 53.1 In-house 32-210 (230) alignment 
Range on Protein: 286-505
Range on HMM: 32-210/230.0
I--RVIGVFDGhgdEGMDASATTRDIISKIVEKEiVNSNDnkksddFYDKCITSSFLEANEALLEKgkiTGDWGTTATLAIIKDNH--IRVGWVGDSMAV
    |.|..||    |..|..... . ... |    .. .        ..... ..|... .| ..    .. |.||..|.|  ..  ..| ..||| ..
rlalvvgdvdG...hGgraalamgllrtalrela.fagle......kpeeilrrlnlalaadlede...psssgaTavvalidpstgklyvanaGdsppl

LFKQSANgkdytpiqlsndhkpenplEKKRIiTTGGRV-V-FRCGcyRVIPNkndysnddimkqrlaLNMSRALGHVVLSK--YGVSSTPEfQSESLNPG
|.....                    |..|| . || . . .. |  || ..               |..|.| | . |      |.. |. .|. . .|
lvrddgg...................ereri.vagglpslGilpg..rvfgv...............lavslapGdllllytDGvveaepd.tsdgelfg

--DYVIVASDGLWNVLDFKACCKYIKKSTS
  ...|.||||||.||. . ..  .... .
kdeflilasdglwdvlspqelvdlvrdele
subfamily_PPM1G_pd Subfamily PPM1G 349-419 3.9e-14 45.5 In-house 289-353 (473) alignment 
Range on Protein: 349-419
Range on HMM: 289-353/473.0
KGKITGDWGTTATLAIIKDNHIRVGWVGDSMAVLFKQsanGKdytPIQLSNDHKPENPLEKKRIITTGGRV
| .   | ||||. |..|.... |  .||| .|| ..   ||    ..|| |||||.. |..||   ||.|
keepGedsGttAvvaLlkekklivAnaGDsRcvlsrn...Gk...AldlslDHkPeDevEleRiekAGGkv
PP2C_SIG_SM00331 284-533 8.5e-14 44.6 In-house 28-212 (217) alignment 
Range on Protein: 284-533
Range on HMM: 28-212/217.0
EGIRVIGVFDGHGdEGMDASATTRDIISKIVEKEIVNsndnkksddfydKCITSSFLEANEALLEKgKITGDWGTTATLAII--KDNHIRVGWVGDSMAV
||  .. |.||.|  | .|.| .. . ... |    .            . ... . ..|.|. |. | ... ..|..||..  .......  .|||  .
egrlllvvaDgmG.kGlaAaaassqlrtalrellseg............eelsqalkrlnraiyee.keekgmfaTlllalydfssgklsyanaGdsrpy

LFKqsaNGKDYTPIQLsndhkpenplekkriittggrvvfrcgcyrvipnkndysnddimkqrlalNMSRALGHVVLSKygvsstPEFQSESLNPGDYVI
|.    .||  ....                                                   .....||. . ..      .. .. .|..|| ..
llr...dgklveilkd..................................................vegaplGlepevs......vdirelelekgdlll

VASDGLWNV-----LDFKACCKYIKKSTsVKELTDLLLSVVESKCQSFKIP--CDNVTI
 ..|||...     .. .  .. .....   |. .|  . ||. ... | .   |..|.
lytDGltearsekgfaeerleeiledlv.dseaqelaqkiveellelakgsngeDdiTv
subfamily_KAPP-like_pd Subfamily KAPP-like 283-416 6.6e-13 41.3 In-house 31-158 (266) alignment 
Range on Protein: 283-416
Range on HMM: 31-158/266.0
SEGIRVIGVFDGHGDEGMDASAttRDIISKIVEKEIVNSNDNKKSDDFYDKciTSSFLEANEALLEKGKITGDWGTTATLAIIK----DNHIRVGWVGDS
.  | ...|||||   |   .|  .... |..|| . ......  |. ||.     ...| . . .| |     |.|||||..       ...|. ||||
csnialfavfdGhaGkGaadaa..kklfpkelekllkstkqddGGdniydq..skllenafkevdaklkdfeyeGatatlalvwsdGqqrylqvanvGds

MAVLFKqsanGKDytPIQLSNDHKPENPLEKKRIITTG
 | | .    | .   ..|| ||| ..| ||.||   |
saflsr....Gne..slelskdhkakdpeekqrikddG
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 355-514 3.3e-12 38.2 In-house 133-292 (317) alignment 
Range on Protein: 355-514
Range on HMM: 133-292/317.0
DWGTTATLAIIKDN-HIRVGWVGD--SMAVLFKQSANG--KDYTPIQLSNDHKPENPLEKKRIITTGG-RVVFRCGCYRVIpnkndysNDDImKQRLALN
|.||||..|.. |. |. |.  ||  .. .| .|. .     .    ||  |. .   |..|.  . . .  .    |  |       .|.   ..  |.
dfGttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsvealsvrhtlrskaerarvaevlpgaahvtedgylai.......ldea.laayelq

MSRALGHVVLSKYGVSSTPEFQSESLNPGDY--VIVASDGLWNVLDFKACCKYIKKSTSVKELTDLLL
....|||  |...||.  || .|. |. ..   |.| |||. . |  .     . .... .| .. | 
ltkslGhkllkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraataleasevlc
PP2C_2 Protein phosphatase 2C 268-491 3.9e-10 32.4 Pfam-A 8-181 (212) alignment 
Range on Protein: 268-491
Range on HMM: 8-181/212.0
TRDENQDTFFqkNFKSEGIRVIGVFDGHGDEG--MDASATTRDIISKIVEKEIVNSNDNKkSDDFYDKCItSSFL----EANEALLEkGKITGDWGTTAT
..  .|| ..   ..... ... | ||.|.    . ...    .. . .|| . ... .. .... ...  .  |     ..||  . ..   | .|| .
kgkpcqDala..ireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqe.eeallrqie.neilasvklkqeaeaq.qeelkdyatTll

LAIIKDNHIRVGWVGDSMAVLFKQSANGKDYTPiqlsnDHKPENPLEkkriittggrvV-----------Frcgcyrvipnkndysnddimkqrlalnms
||.|....| ....||...|..... . .  .      ... |   |           .           .                             
lavitpgeivffqiGDgaivvrdrdgevqllge.....pdsgeyane...........ttfltsedaeeel.............................

ralghvvlskygvsstpEFQSESLNPGDYVIVASDGLWNVL
                 ....  |.||| ... .||... |
.................rirrlklepgdalllmTDGvsdsl
PP2C_2 Protein phosphatase 2C 268-491 3.9e-10 32.4 In-house 8-181 (212) alignment 
Range on Protein: 268-491
Range on HMM: 8-181/212.0
TRDENQDTFFqkNFKSEGIRVIGVFDGHGDEG--MDASATTRDIISKIVEKEIVNSNDNKkSDDFYDKCItSSFL----EANEALLEkGKITGDWGTTAT
..  .|| ..   ..... ... | ||.|.    . ...    .. . .|| . ... .. .... ...  .  |     ..||  . ..   | .|| .
kgkpcqDala..ireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqe.eeallrqie.neilasvklkqeaeaq.qeelkdyatTll

LAIIKDNHIRVGWVGDSMAVLFKQSANGKDYTPiqlsnDHKPENPLEkkriittggrvV-----------Frcgcyrvipnkndysnddimkqrlalnms
||.|....| ....||...|..... . .  .      ... |   |           .           .                             
lavitpgeivffqiGDgaivvrdrdgevqllge.....pdsgeyane...........ttfltsedaeeel.............................

ralghvvlskygvsstpEFQSESLNPGDYVIVASDGLWNVL
                 ....  |.||| ... .||... |
.................rirrlklepgdalllmTDGvsdsl
subfamily_ILKAP_pd Subfamily ILKAP 447-512 5.9e-10 31.8 In-house 185-251 (293) alignment 
Range on Protein: 447-512
Range on HMM: 185-251/293.0
LNMSRALGHVVLSKYGVSSTPEFQSESLNPGD-YVIVASDGLWNVLDFKACCKYIKKSTSVKELTDL
|..||..|     . ||.|||. .   |.. | .|..| ||||.|.. ..  |.| |    .|  . 
levsrsiGdgrfkrlGvistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrk
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 283-416 6.6e-10 31.3 In-house 30-168 (276) alignment 
Range on Protein: 283-416
Range on HMM: 30-168/276.0
SEGIRVIGVFDGHGDEGMDASAttRDIISKIVEKEIVN-----SNDNKKSDDFYDKciTSSFLEANEALLEKGKITGDWGTTATLAIIKDN---------
.  | ...|||||   |   .|  .... |..|| .       .....  |. ||.  .  .|.. . . .| |     |.|||||..  .         
csnialfavfdGhaGkGaadaa..kklfpkelekllksgnysltkqddGGdniydq..skllldlfkevdaklkdfeyeGatatlalvwsdGeeqqqqqq

-HIRVGWVGDSMAVLFKqsanGKDytPIQLSNDHKPENPLEKKRIITTG
 ...|. |||| | | .    | .   ..|| ||| ..| ||.||   |
rylqvanvGdssaflsr....Gne..slelskdhkatdpeekqrikddG
subfamily_PDP_pd Subfamily PDP 352-413 2.8e-09 29.6 In-house 148-208 (398) alignment 
Range on Protein: 352-413
Range on HMM: 148-208/398.0
ITGDWGTTATLAIIKDNHIRVGWVGDSMAVLFKQSANGKdYTPIQLSNDHKPENPLEKKRII
 ..  |..|.|| |..... |  .||. ||| .|. .|. .. ..||.|.  .|. | .|| 
lvalsGacallaliegtelhvAntGDcravlgvqeeegs.weavkLskdqtadneeEveRik
subfamily_TAB1_pd Subfamily TAB1 357-414 1.5e-08 26.8 In-house 130-184 (333) alignment 
Range on Protein: 357-414
Range on HMM: 130-184/333.0
GTTATLAIIKDNHIRVGWVGDSMAVLFKQSAngkDYTPIQLSNDHKPENPLEKKRIIT
|||| .|.|  |.. |  |||| |.| |.          ||| ||. .|. | .|.  
GttAvvalifnnkLyVaNvGdsrAllvkrke...sekvkqLsvdHttdNedEllRlkd
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 447-534 9e-08 24.3 In-house 181-272 (276) alignment 
Range on Protein: 447-534
Range on HMM: 181-272/276.0
LNMSRALGHVVLS--KYGVSSTPEFQS-ESLNPGD-YVIVASDGLWNVLDFKACCKYIKKSTSVKELTDL-LLSVVESKCQSFKIpCDNVTIC
| .|||||.  .     |..|.|   .  .| | | ..||||||||.|.. |   . .|     ..  |    |..|.  || |   |||.. 
lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsika.kdnvsvi
subfamily_KAPP-like_pd Subfamily KAPP-like 447-534 9.2e-08 24.4 In-house 171-262 (266) alignment 
Range on Protein: 447-534
Range on HMM: 171-262/266.0
LNMSRALGHVVLS--KYGVSSTPEFQS-ESLNPGD-YVIVASDGLWNVLDFKACCKYIKKSTSVKELTDL-LLSVVESKCQSFKIpCDNVTIC
| .|||||.  .     |..|.|   .  .| | | ..||||||||.|.. |   . .|     ..  |    |..|.  || |   |||.. 
lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsika.kdnvsvi
PPM_PTC7_SpoIIE_motif 471-535 4.4e-07 23.5 In-house 6-77 (81) alignment 
Range on Protein: 471-535
Range on HMM: 6-77/81.0
SESLNPGDYVIVASDGLW-------NVLDFKACCKYIKKS--TSVKELTDLLLSVVESkcqsF--KIPCDNVTICC
.. | ||| .....|||.       .... .. ......    | .|| | |.  |..         . |..|. .
efqLkpgdvllLyTDGltEardsdgelfgkeellrladraegkslqeladklvdevle....ngsgereDDitllv
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 272-315 6.5e-07 20.8 In-house 10-55 (317) alignment 
Range on Protein: 272-315
Range on HMM: 10-55/317.0
NQDTFFQKNFKSEGIR--VIGVFDGHGDEGMDASATTRDIISKIVE
|||..|   || .| |  .  |||||.  |  |.| .|| ....  
nqdvyflasfklaGhrialaavfdGhsllGeiaaamardtltallP
subfamily_PPM1G_pd Subfamily PPM1G 447-518 1.8e-06 20.2 In-house 363-442 (473) alignment 
Range on Protein: 447-518
Range on HMM: 363-442/473.0
LNMSRALGHVV--------LSKYGVSSTPEFQSESLNPGD-YVIVASDGLWNVLDFKACCKYIKKSTSVKELTdLLLSVVE
||.|||||  .        |    .|  |. . . | . | ....|.||.|||.. .    ....  . .| .  | ..||
LnlsRAlGDhaYkkneeLplkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgees.vlseive