Gene DDB_G0284243 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP107_AA protein Get Run
DdisP107_AA_146-403 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1A_pd Subfamily PPM1A 147-403 3.7e-83 272.1 In-house 8-280 (282) alignment
Range on Protein: 147-403
Range on HMM: 8-280/282.0
KTRSVRdFGVSFEKNarYRRTMEDEHVIIDCFGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLD-------EINKSPEGDILELFRNSYLLTDKQMNE
.....| .|||  ..  .|..|||.|... ..|. .....||..|||.|. ......|.|. |.|.       ....|.. ...| .|...| .|....|
egnglr.ygvssmqg..wrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeaire

SEIQFS-----GTTSITALIRknpvdgEKYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNGRVNGILAVTRSLGDHSMKD----
.. . .     |.|..|.|..      ||.|..||.||.|||.|.|. |..|..|||.|.|.| |||..|||.|...|||| |||.|.|||...|.    
lstdlktadksGsTavtvlvs......ekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeek

-----HVIGDPYKRSIKLDSGHTHLILACDGLWDVTSDQDAVDLILNE----TEAQKMSDKLLLHALKKGSTDNISIIVVIL
     .|...|. .||. .. ...|.|||||.|||.||...|.|. ..    .|.......|. .||.|||.||.|..||..
kaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlf

0034914 PP2C-like 151-403 1.8e-68 223.4 In-house 18-290 (295) alignment
Range on Protein: 151-403
Range on HMM: 18-290/295.0
VRDFGVSFEKNARYRRTMEDEHVIIDCFGG-DANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDE------INKSPEGDILELFRNSYLLTDKQMNESEIQ
   . |..  .  .|...|| .... ..   . ....|...|||||  | |. ...|. .||..      .. ... ||.| .|...| .|... |  ..
llllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelall

-----FSGTTSITALIRKNpvdgekYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNGRVNGILAVTRSLGDHSMK---------
     .|||| ..||||.|      .|||||.|| |||...|.....|..||| ....|..|| .|||.| .|||||.|||||.|||...|         
rpelagsGtTavvalirgn......klyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllslllle

DHVIGDPYKRSIKLD-SGHTHLILACDGLWDVTSDQDAVDLILN----ETEAQKMSDKLLLHALKKGSTDNISIIVVIL
 .|.  |. ....|. . .  |.||.|||||| |....||.. .     .........|. .||..||.|||...|| |
plvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrl

PP2C Protein phosphatase 2C 155-396 5.7e-68 222.2 Pfam-A 2-255 (255) alignment
Range on Protein: 155-396
Range on HMM: 2-255/255.0
GVSFEKNARYRRTMEDEHVIID---CFGGDANQGYFAIYDGHGGRGAVEFTAKTLHvNLLDEINKSPEG-DILELFRNSYLL-TDKQMNE---S-EIQFS
.|..... ..|..|||.|....   . .|. . ..||..|||||| | ......|. ..|.|  . .|. .  ...|.|.|  ||....    . | . |
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehle.eilkeqksflelekvekalrksfladtdeelksskantepsks

GTTSITALIRKNPvdgekyLYVANAGDARAVVCHNKVAE-RLSYDHKGSDPEEVKRIDAAGGFVC-NGRVNGILAVTRSLGDHSMKD----HVIGDPYKR
|.|...||||..       |||||.||.|||.| .. |. .|..||| ||..|..|| .|||.|  |||||| |||.|.|||. .|.    .|. .|. .
Gstavvalirgkk......lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvt

SIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETE----AQKMSDKLLLHALKKGSTDNI
|.||.. .  ||||.|||||| |||.||||. .| .    .......|. .|...||.|||
svklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni

PP2C Protein phosphatase 2C 155-396 5.7e-68 222.2 In-house 2-255 (255) alignment
Range on Protein: 155-396
Range on HMM: 2-255/255.0
GVSFEKNARYRRTMEDEHVIID---CFGGDANQGYFAIYDGHGGRGAVEFTAKTLHvNLLDEINKSPEG-DILELFRNSYLL-TDKQMNE---S-EIQFS
.|..... ..|..|||.|....   . .|. . ..||..|||||| | ......|. ..|.|  . .|. .  ...|.|.|  ||....    . | . |
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehle.eilkeqksflelekvekalrksfladtdeelksskantepsks

GTTSITALIRKNPvdgekyLYVANAGDARAVVCHNKVAE-RLSYDHKGSDPEEVKRIDAAGGFVC-NGRVNGILAVTRSLGDHSMKD----HVIGDPYKR
|.|...||||..       |||||.||.|||.| .. |. .|..||| ||..|..|| .|||.|  |||||| |||.|.|||. .|.    .|. .|. .
Gstavvalirgkk......lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvt

SIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETE----AQKMSDKLLLHALKKGSTDNI
|.||.. .  ||||.|||||| |||.||||. .| .    .......|. .|...||.|||
svklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni

PPM_PTC7 156-396 7.3e-68 221.8 In-house 3-259 (259) alignment
Range on Protein: 156-396
Range on HMM: 3-259/259.0
VSFEKNARYRRTMEDEHVIID---CFGGDANQGYFAIYDGHGGRGAVEFTAKTLHvNLLDEINKSPEG-DILELFRNSYLL--TDKQMNE---S-EIQFS
...... ..|..||| |.. .   . .|. . ..||..|||||| | ......|. . |.|    .|. .  . .|.|.|   ||. ..    . | . |
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehle.eilkerksfeeleklekalrksflaldtdeelksseantepsts

GTTSITALIRKNPvdgekyLYVANAGDARAVVCHNKVAE-RLSYDHKGSDPEEVKRIDAAGGFVC---NGRVNGILAVTRSLGDHSMKD------HVIGD
|.| ..|||...       |||||.||.|||.| .. |  .|..||| |...|..|| .|||.|    |||||| |||.|..||. .|.      .|. .
GstAvvalitgsk......lyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsae

PYKRSIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETEA---QKMSDKLLLHALKKGSTDNI
|.  |.|.|. . .||||.|||||| |||.||||. .| ..   .. ..||. .|...||.|||
PdisstkideedefliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargsedni

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 153-402 1.7e-66 217.1 In-house 5-252 (255) alignment
Range on Protein: 153-402
Range on HMM: 5-252/255.0
DFGVSFEKNARYRRTMEDEHVIIDCFGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSPEgDILELFRNSYLLTDKQMNESEiQFSGTTSITA
 | |.| .    | ||||| ||   | .. .. |.|..|||||| | .|....|.  | . ..  .  . .. ....|  .. |..|   .| |||....
rfkvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnna.nPvkslkkaykeistqiserp.kfiGttaasv

LIRKNpvdgekYLYVANAGDARAVVC-HNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNG----RVNGILAVTRSLGDHSMKDHVIGDPYKR-SIKLDSG
|| ..      . |.|| ||.|.|.| .. .|.|||.||| |...| ||| ..||.| ..    |||| |||.|.|||  .. .|. ||.   |..    
liied......kvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskk

HTHLILACDGLWDVTSDQDAVDLILNETEAQKMSDKLLLHALKKGSTDNISIIVVI
. .|||||||.||. ||..||..... ....| . ||  .| ..|||||||.||. 
dkflilacdGiwdlisdeeaveivagisdpekaaeklrdlayssGstdnisvivik

PP2Cc_SM00332 147-401 1.2e-65 214.7 In-house 3-274 (274) alignment
Range on Protein: 147-401
Range on HMM: 3-274/274.0
KTRSVRDFGVSFEKNARYRRTMEDEHVIIDCFGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSPE---GDILELFRNSYLLTDKQMNESEI-
...|. ..  .. ..  .|..||| ||.. ..   .. ..|...|||||  ...|..| |. .| .|..|  .    |. |. ....| ||....|.|  
esgsnlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqs

-----QFSGTTSITALIRKNPvdgekyLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNGRVNGILAVTRSLGDHSMK-------D
     . ||.| ..||..|.       |||||.|| |||.| |. | .||.|||..|..|.||| .|||.| .||||| |||.|..||| .|        
kelenalsGstavvallkked......lyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknkklkep

HVIGDPYKRSIKLDSGHTHLILACDGLWDVTSDQDAVDLILNET------EAQKMSDKLLLHALKK-GSTDNISIIVV
... .|    ..|.| .  ||||.|||||| |.|..||.. .        ..|.....|  .|... ||.|||...||
yitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv

subfamily_PPM1E_pd Subfamily PPM1E 162-403 1.7e-56 184.4 In-house 12-262 (265) alignment
Range on Protein: 162-403
Range on HMM: 12-262/265.0
ARYRRTMEDEHVIIDCF----G--GDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSPEGDilELFRNSYLLTDKQMNES---EIQFSGTTSITA
   ||.||| ||... .    .  .. .. .||..|||||  | ...|. || .| .. .   .    | ..... |||... .    |   ||.|....
knkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa..ealkeafkltDerflqkaereklksGstavvv

LIRKNPvdgekyLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCN---GRVNGILAVTRSLGDHSMKDHVIGDPYKRSIKLDSGHTH
||.|.       ||||  ||..|.....  | .|   || ....| |||..|||.|..    ||||.|.|.|..|| . |..|.|..   ...||. .  
liekdq......lyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaeveldgseey

LILACDGLWDVTSDQDAVDLILNET-----EAQKMSDKLLLHALKKGSTDNISIIVVIL
|||||||||||  ....|.|. .       . .... .|. .| ..||.|||...||.|
lilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl

0049733 PP2C-like 163-402 3.4e-53 173.3 In-house 13-232 (235) alignment
Range on Protein: 163-402
Range on HMM: 13-232/235.0
RYRRTMEDEHVIidcfggdaNQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSPEGDILELFRNSYLLTDKQMNESEIQF-----SGTTSITALIRkn
|.|...|| ...        ....||..|||||  | |. ...|. .||... . .. |..|..|...| ..... |  ..      .||| ..||..  
rvrkvneDavlv........glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmgtTavvalld..

pvdgEKYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVcngRVNGILAVTRSLGDHSMKdhvigdPYKRSIKLDSGHtHLILACDGL
    ...|||||.|| ||...... ...|..||. ....|..|| .|||.|   ||.|.||.||.|||. .|      |. ....|..|.  |.||.|||
....ggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk......pdvtvlelepgd.flllasDGl

WDVTSDQDAVDLILNeTEAQKMSDKLLLHALKKGSTDNISIIVVI
||| ||...|||. . ...... ..|. .||..|..|||...|| 
wdvlsdeeivdllrs.ldleeaaerlvelalarggrDNiTvvvvr

subfamily_PPM1G2_pd Subfamily PPM1G2 163-403 6.7e-52 169.2 In-house 28-286 (287) alignment
Range on Protein: 163-403
Range on HMM: 28-286/287.0
RYRRTMEDEHVI-IDC--FGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSpEGDILELFRNSYLLTDKQMNES---EIQFSGTTSITALIRK
 ||..||| |..  .      | .  .||..|||||. . ....| |.  .    . . || . .......| ||... .    . . .|.|....||..
GyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfk.egaleqilkdafletDeellkdeklkdesaGstavvvlike

NPvdgekyLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNGRVNGILAVTRSLGDHSMKDHVIGDPYKR---------SIKLDSGH
.       ||||||||.|||....  .. ||.||| .. .| ||| ||||||  .|||| ||. |.|||.. |..|   |  .           |||. .
ek......lyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkkldedd

THLILACDGLWDVTSDQDAVDLI----LNETEAQKMSDKLLLHALKKGST------DNISIIVVIL
  |.|||||.||| .... |||.     .... ......|| ..|.. |       ||.....|.|
eflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl

subfamily_PPM1L_pd Subfamily PPM1L 165-402 4.5e-44 143.7 In-house 16-265 (269) alignment
Range on Protein: 165-402
Range on HMM: 16-265/269.0
RRTMEDEHVIIDCFGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEI-----NKSPEG--DILELFRNSYLLTDKQMNES---EIQFSGTTSITALI
|  |||   | .    .... .||..|||||  | ||. . |  ......     .|  .   .  .|. .  |  |... |    . . .|||.. ||.
rprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraediaGttalialv

RknpvdgEKYLYVANAGDARAVVCHNK-VAERLSYDHKGSDPEEVKRIDAAGGFVC-NG--RVNGILAVTRSLGDHSMKDH--VIGDPYKRSIKLDSGHT
.      |. | ||| ||.| |.. ..  |  ||.|||  ...| |||  ||||.. .|  ||.|.||..|.|||. .||.  || ||   ...||  . 
q......esdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdiltfdlddhkp

H-LILACDGLWDVTSDQDAVDLILNETEAQKMSDK-LLLHALKKGSTDNISIIVVI
. ||||.|||||  |...||  |... .  ..  | | |.. |.||.|||...|| 
eflilasdGlwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvk

subfamily_ILKAP_pd Subfamily ILKAP 164-401 4.1e-40 130.8 In-house 15-290 (293) alignment
Range on Protein: 164-401
Range on HMM: 15-290/293.0
YRRTMEDEHVIIDCFGGD---A-----NQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSPE----GDILELFRNSYLLTDKQMNE----SEIQ-FSG
 | .|.|.|||.. .  .   .     .  |.|..|||.|. | ||.|..|| ..|... ||       .|   . .|.  ||... .    .. .   |
ereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskakPvWkdG

TTSITALIRKNpvdgekYLYVANAGDARAVVCHNKVAER------LSYDHKGSDPEEVKRIDAAGGFVCNGRVNGILAVTRSLGDHSMKDH-VIGDPYKR
.| .. |.  |       ||||| ||..||.. .| . .      |. ||.  . || |||. |||.| .|||.|.| |.||.||   |   ||  |  .
statvvlvldn......vlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlGvistPdvk

SIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETEAQ--------------------KMSDKLLLHALKKGSTDNISIIVV
 ..|.    ...|||||||.| | ...|. ||.  |..                      ...|  .|.|.||.||.....|
kceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllv

subfamily_KAPP-like_pd Subfamily KAPP-like 168-403 5.3e-39 126.9 In-house 12-266 (266) alignment
Range on Protein: 168-403
Range on HMM: 12-266/266.0
MEDEHVIIDCFGGDA------NQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINK-------SPEGDILELFRNSYLLTDKQMNESEiqFSGTTSITALI
||| .. |  .. .       | . ||..||| |.|| . . | .  .| . ...        .  |  .|..|..   |..... |  . |.|.  ||.
medvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfe..yeGatatlalv

RKNPvdGEKYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNG--RVNGIlAVTRSLGDHSMKDHVI---GDPYK-RSIKLDSGHT
 ..     .|| ||| ||. | ...   .  ||.|||  |||| .||   |  ....  |.||. ||.|.|||| .|.  |   ..||    | |   . 
wsdG..qqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdk

HLILACDGLWDVTSDQDAVDLILN----ETEAQKMSDKLLLHALKKG-STDNISIIVVIL
.||.| |||||| | .||.. .      .. ..||.. ||  |..   . ||.|.||| |
flivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl

subfamily_PPM1K_pd Subfamily PPM1K 181-402 1.4e-38 125.5 In-house 28-257 (263) alignment
Range on Protein: 181-402
Range on HMM: 28-257/263.0
DANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEInkSPEGDILELFRNSYLLTDKQM--------NESEIQFSGTTSITALIRknpvDGEKyLYVANAGD
| .  |.|..|||.|  |..|. . |.  | .      | |. ....|...  ||..         |.| . ||||.  .|.|    || . | .|. ||
dpellyvavfdGhaGsaaadfvhdklekilkrll..ekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllr....dGte.lvlaslGd

ARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVC-----NGRVNGILAVTRSLGDHSMKDH-VIGDPYKRSIKLDSG-HTHLILACDGLWDVTSDQD
.||..| |  |..|. ||. .  || .|| ||||.|      . .||| ||.||||||  .| . || .|  .|.|.| .  . |.|  ||. .| ..|.
srailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqe

AVDLILNETEAQKMSDKLLLHALKKGSTDNISIIVVI
  ||.   .. .. .. |   ||. || || ...|| 
lcdlvrlchdpeeaahalteqalqygsednatavvvp

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 168-403 1.9e-36 118.3 In-house 11-276 (276) alignment
Range on Protein: 168-403
Range on HMM: 11-276/276.0
MEDEHVIIDCFGGDA------NQGYFAIYDGHGGRGAVEfTAKTLHVNLLDEINKS-------------PEGDILELFRNSYLLTDKQMNESEiqFSGTT
||| .. |  .. .       | . ||..||| |.|| . .|| |  . |  . ||             .  |  .|. . .   |..... |  . |.|
medvslaiyplldekdlsncsnialfavfdGhaGkGaad.aakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfe..yeGat

SITALIRKNP----VDGEKYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVCNG--RVNGIlAVTRSLGDHSMKDHVI---GDPYK-
.  ||. ..      . ..|| ||| ||. | ...   .  ||.||| .||||..||   |  ....  |.||. ||.|.|||| .|.  |   ..||  
atlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinGl.avsralGdhfikelniGlisepyvs

RSIKLDSGHTHLILACDGLWDVTSDQDAVDLILN----ETEAQKMSDKLLLHALKKG-STDNISIIVVIL
  | |   . .||.| |||||| | .||.. .      .. ..||.. ||  |..   . ||.|.||| |
nrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl

PPM_PTC7_SpoIIE 156-395 2.9e-35 115.2 In-house 3-229 (230) alignment
Range on Protein: 156-395
Range on HMM: 3-229/230.0
VSFEKNARYRRTMEDEHVIID---CFGGDANQGYFAIYDGHGGRGavEFTAKTLHvNLLDEINkSPEGD-ILELFRNSYLLTDKQMNESeIQFSGTTSIT
... .. ..|..||| |.. .   . .|.    .....||||||    .....|. ..|.|.   ....   |..|...|. .......  . ||.| . 
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllr.talrela.faglekpeeilrrlnlalaadlede.psssgaTavv

ALirknpVDGEK-YLYVANAGDARAVVCHNKVAerlsydhkgsdpeEVKRIdAAGGFV-C---NGRVNGILAVTRSLGDHSMKD---HVIGDPYkRSIKL
||     .|...  |||||||| ........               |..|| .|||..     .|||.| |||... ||  ...    |   |.  | ..
al.....idpstgklyvanaGdsppllvrddgg.............ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvveaepd.tsdge

DSG-HTHLILACDGLWDVTSDQDAVDLILNETEAQkMSDKLLLHALKKGSTDN
. | . .||||.|||||| |.|..|||...| |.  ....|| ...  .....
lfgkdeflilasdglwdvlspqelvdlvrdelekp.aaeglleDDitllvvrv

subfamily_PPM1G_pd Subfamily PPM1G 237-380 1e-32 106.8 In-house 288-435 (473) alignment
Range on Protein: 237-380
Range on HMM: 288-435/473.0
MNESEIQFSGTTSITALIRKNpvdgekYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVC-NGRVNGILAVTRSLGDHSMKDHVIG-
 .|.. . |||| . ||....       |.||||||.|.|...| .|  ||.|||  |..| .||..||| |  .||||| | . | ||||. |      
ekeepGedsGttAvvaLlkek......klivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLp

--------DPYKRSIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETEAQKMS
         |  .  .| . .  |.|||||.|.| . |. || . .. . .. |
lkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgees

subfamily_PP2D1_pd Subfamily PP2D1 264-372 7.7e-25 80.5 In-house 189-304 (492) alignment
Range on Protein: 264-372
Range on HMM: 189-304/492.0
YLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGGFVC----NGRVNGILAVTRSLG---DHSMKDHVIGDPYKRSIKLDSGHTHLILACDG
 ||.||||. .||.|.. .| .|  .|   ...| .|.  ||. |     ||.||||| .|| ||   |  .|  || .|. .|.|||     |.||  |
vlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaaqflvlAsnG

LWDVTSDQDAVDLILN
||.| |... . |. .
lWevlseeevlsLvkq

subfamily_PHLPP_pd Subfamily PHLPP 186-402 3.6e-20 64.9 In-house 29-244 (246) alignment
Range on Protein: 186-402
Range on HMM: 29-244/246.0
YFAIYDGHGGRGAVEFTAKTLHVNLLDEINKSPEGdiLELFRNSYLLTDKQMNEsEIQFSGTTSITALIRKNPVDGEK--YLYVANAGDARAVVCHNKVA
 . ..||.  .   .   ....  |..|..|. .    |  .| .| . ... | . .  |.. .  |||...||  |   | ||. |   ||.. |.  
lyGlfdGdrneelssllqrlmkdvlkeevqkdkne..eeymkntllvaqrklGe.aGeklgsaallilirhdkvdPaksfsLevAsvGtlqavliRngkk

ERLSYDHKGSDPeEVKRIDAAGGFVC-NGRVNGILAVTRSLGDHSMKDHVIGDPYKRSIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETEAQKMSDK
 |||  .. ..  |.|||  | ...  ....||... || ||  ..   |. .|  |...| .    ||.  . ||.| | ..||. . .| ..     |
lrlsksyviekd.elkrikeakaiitednkingviestrllGytflfPvvlPkphvrevlLteqdellivGnkalWevlsideaveavrkeedplvaAkk

LLLHALKKGSTDNISIIVVI
|   |   | .|..|..|| 
lvdlaqsygaadsvsvlvvr

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 187-336 3.5e-18 59.1 In-house 24-194 (292) alignment
Range on Protein: 187-336
Range on HMM: 24-194/292.0
FAIYDGHG--GRGAVEFTAKTLHVNLLDEINksPEGDILELFRNSYLLTDKQMNESEIQFSGTTSITALIRKNPvDgEKYLYVANAGDARAVVCH-----
 |..||||  |.   .....|| |.||.  .  .  .. | . .  | .  ..... |.    .. ..   . . | .. |..|| ||.||..       
aavldGhGvnGdkvaqlaedtlevelleltr..qlqelsealllrildiaakldkltidaresattavvcarvr.d.dralilanvGdsrallgrclggs

NKVAERLSYDHKGSDPEEVKRIDAAGGFVC-----------NGRV------NGILAVTRSLGDH-SMKDHVIGDP
..    || ||| .||.| .|| .|||.|              ||      .| ||..|.|||   ..  |. .|
dyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaeP

subfamily_PPM1D_pd Subfamily PPM1D 157-310 4e-18 58.6 In-house 5-173 (309) alignment
Range on Protein: 157-310
Range on HMM: 5-173/309.0
SFEKNARYRRTMEDEHVIIDCF---GGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLD--EINKSPEGDILELFRNSYLLTDKQMNESEIQ--------
. | ..  |. |||  .|       . . .. ..|..|||||. | .|. . |  .. .  ..  |.. |.||  |...| | ..|...  .        
tseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgl

--FSGTTSITALIRKNpvdgekYLYVANAGDARAVVCHNKV------AERLSYDHKGSDPEEVKRIDAAGGFVCN
   .|||  . .||..       ||||. ||...|.  ..       |. |  ||| ..|||..||. .|| | .
lstaGttasvviirre......klyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaa

subfamily_PP2D1_pd Subfamily PP2D1 153-216 2.6e-17 55.7 In-house 2-65 (492) alignment
Range on Protein: 153-216
Range on HMM: 2-65/492.0
DFGVSFEKNARYRRTMEDEHVIIDCFGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINK
 .|.  .||.|.. .|||.... | || |.|...|.||||. |. | | .||.||. ||.|..|
avGiCedknsrWKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelek

PPM_PTC7_motif 351-396 1.3e-14 47.4 In-house 1-51 (51) alignment
Range on Protein: 351-396
Range on HMM: 1-51/51.0
ILACDGLWDVTSDQDAVDLILNETEA-----QKMSDKLLLHALKKGSTDNI
|||.|||||| |||.||||.  . ..     |. . ||  .||..||.|||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni

subfamily_TAB1_pd Subfamily TAB1 245-330 6.5e-12 37.9 In-house 129-214 (333) alignment
Range on Protein: 245-330
Range on HMM: 129-214/333.0
SGTTSITALIRKNpvdgekYLYVANAGDARAVVCH---NKVAERLSYDHKGSDPEEVKRIDAAGGFVCNGRVNGI---LAVTRSLGDHSMKD
 ||| . |||  |       |||||.||.||....   ..  . || ||.   ..|..|.   |  . . . |..      |||.||...| 
gGttAvvalifnn......kLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkk

PP2C_SIG_SM00331 178-401 1e-11 37.8 In-house 24-215 (217) alignment
Range on Protein: 178-401
Range on HMM: 24-215/217.0
FGGDANQGYFAIYDGHG-GRGAVEFTAKTLHvnLLDEINKSPeGDILELFRNSYLLTDKQmneSEIQFSGTTSITALIrkNPVDGEkyLYVANAGDARAV
.  .. .  ... ||.| |  | ........  .|.|. ..   .. .....   . ...   .| . ...| . ||.  .. .|.  |..||||| | .
vklnegrlllvvaDgmGkGlaAaaassqlrt..alrellseg.eelsqalkrlnraiyee...keekgmfaTlllaly..dfssgk..lsyanaGdsrpy

VCHnkvAERLSYDHKGsdpeevkridaaggfvcngrvngilAVTRSLG--DHSMkdhvigdPYKRSIKLDSGHThLILACDGLWDVTSDQ----DAVDLI
. .    ..| ...|                            .. ||  ....       .. |...|. | . |.|. |||... |..    . . .|
llr...dgklveilkd.........................vegaplGlepevs.......vdirelelekgdl.lllytDGltearsekgfaeerleei

LNET---EAQKMSD----KLLLHALKKGSTDNISIIVV
| ..   |||....    .|| .|  ..  |.|...||
ledlvdseaqelaqkiveellelakgsngeDdiTvvvv

subfamily_PDP_pd Subfamily PDP 234-329 4.1e-11 35.6 In-house 140-241 (398) alignment
Range on Protein: 234-329
Range on HMM: 140-241/398.0
DKQMNE-SEIQFSGTTSITALIRKNPvdgekyLYVANAGDARAVVCHNK-----VAERLSYDHKGSDPEEVKRIDAA------GGFVCNGRVNGILAVTR
.|...|  .  .||.....|||...       |.|||.||.|||.. ..      | .|| |. .. .|||.|| ..         . |||. | |. .|
ekslreallvalsGacallaliegte......lhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlR

SLGDHSMK
  ||   |
AFGdvryK

subfamily_PPM1G_pd Subfamily PPM1G 142-241 9.7e-11 34.3 In-house 7-103 (473) alignment
Range on Protein: 142-241
Range on HMM: 7-103/473.0
TEPSSKTRSVRDFGVSFEKNARYRRTMEDEHVIIDCFggDANQGYFAIYDGHGGRGAVEFTAKTLHvNLLDEINKSPEGDILELFRNSYLLTDKQMNESE
.| .|...| ... ...     .|  .|| |  |  .  | .   ||.||||||.   ...||.|  .|| . .   |||. . .....|  |..... |
vekesedesneelsygasamqGwrvsqEDahncitdl..dedtslfavyDGHGGkevakyvakklp.dllkaqkgykegdvekaleeaflalDeklkaee





Subfamily Dicty-PPM1L-like 300-402 3.2e-10 32.3 In-house 185-302 (305) alignment
Range on Protein: 300-402
Range on HMM: 185-302/305.0
RIDAAGGFVCN-G--RVNGILAVTRSLGDHSMKDHVIGDPYKRSIKL-DSGHTHLILACDGLWDVTSDQDAVDLIL---NETEAQK--------MSDKLL
||. ... . | |  .||..| . || || ..|  || .. .    . ...   |.|| ||||.| | || |. ..   ...  ||        .|    
rieslqaalynygellvnrllkksrskGdknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviv

LHALKKGSTDNISIIVVI
  |.|.|| ||| .... 
eeavkrgsgDnitlviik

subfamily_PPM1D_pd Subfamily PPM1D 317-403 6.4e-10 31.6 In-house 201-307 (309) alignment
Range on Protein: 317-403
Range on HMM: 201-307/309.0
LAVTRSLGDH-----SMKDHVI-GDPYKRSIKLDSGHT-HLILACDGLWDVTSDQDAVDLILNETEAQKM--------SDKLLLHALKKGST-----DNI
|||.|||||       .. .|.  .|.    .||  .. ..||| ||||.| . .|||... .| | ...        . .|. .||.. ..     ||.
LavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnv

SIIVVIL
|.|||||
svivvil

PPM_PTC7_SpoIIE_motif 341-401 3.7e-09 30.1 In-house 7-78 (81) alignment
Range on Protein: 341-401
Range on HMM: 7-78/81.0
IKLDSGHThLILACDGLW-------DVTSDQDAVDLILNE--TEAQKMSDKLLLHALKKG---STDNISIIVV
..|  | . |.|..|||.       .. .......|. ..   ..|...|||. ..|. |   ..|.|...|.
fqLkpgdv.llLyTDGltEardsdgelfgkeellrladraegkslqeladklvdevlengsgereDDitllvl

subfamily_PPM1H_pd Subfamily PPM1H 230-291 1.7e-07 23.4 In-house 144-202 (404) alignment
Range on Protein: 230-291
Range on HMM: 144-202/404.0
YLLTDKQMNESEIQFSGTTSITALIRknpVDGEKYLYVANAGDARAVVCHNKVAERLSYDHK
.|  |.|... . ..  .   |||.    .  .. ||||||||.||......    || |. 
flemDeqiarereayrikGGCtalva...lvllgklYvanaGDsRailvrkdeiiplsadft

subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 317-387 2.1e-07 22.4 In-house 223-295 (317) alignment
Range on Protein: 317-387
Range on HMM: 223-295/317.0
LAVTRSLGDHSMKD-HVIGDPYKRSIKLDSGHTHLILAC-DGLWDVTSDQDAVDLILNETEAQKMSDKLLLHA
| .|.||| . .|   || ||  ||  || . .. .... ||. |  . .| .| .|. . |.. |..|   |
lqltkslGhkllkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraataleasevlcdda

Subfamily Dicty-PPM1L-like 245-306 9.8e-07 20.9 In-house 211-270 (305) alignment
Range on Protein: 245-306
Range on HMM: 211-270/305.0
SGTTSITALIRknPVDGEKYLYVANAGDARAVVCHNKVAERLSYDHKGSDPEEVKRIDAAGG
 |  ... |.   | . .. | ||.|.| . |.. . ..| |||...  ...|. |.   ..
kGdknlkelvi..PnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqk

subfamily_PDP_pd Subfamily PDP 336-383 1.3e-06 20.7 In-house 274-321 (398) alignment
Range on Protein: 336-383
Range on HMM: 274-321/398.0
PYKRSIKLDSGHTHLILACDGLWDVTSDQDAVDLILNETEAQKMSDKL
|   | || .    |.|| |||||. |....|.|. . .. .| ....
PevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepv

subfamily_PPM1H_pd Subfamily PPM1H 175-216 6.3e-06 18.2 In-house 53-94 (404) alignment
Range on Protein: 175-216
Range on HMM: 53-94/404.0
IDCFGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDEINK
 . .   ..  ||...|||.| ||   ..|.||  | .....
ekseeeklplayfglfDGhaGsgaalvaskllhkhlkekled