Gene DDB_G0272680 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP108_AA protein Get Run
DdisP108_AA_838-1146 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Subfamily Dicty-PPM1L-like 862-1147 7.1e-136 445.0 In-house 1-305 (305) alignment 
Range on Protein: 862-1147
Range on HMM: 1-305/305.0
NHVILEYPYELYglekkksvdsiAGANSNSNNNNNNNNCISILSSNEQFFFGVFDGHNGKIAAEYSRVNLpYEIFNSFIKINKVGNSANNNNVDDLCLEA
||.|||..||||           ..|||.......|...||..||.|...|||||||||.|||||....| .||.|...|.||||.||.|.|||||.|||
nhliletkyely...........vsansrkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkkl.veivnkyvkenkvGysaknlnvddlplea

IKQGYLNTDKYFLDYAESDNKKAGTTV----ATVILERERFIVSNAGDTEVVLCSGGIAEPLSIIHTPK---------------------LDTERIRIES
||...|.|||..||.|||||||||||.    |.|||||||.|||.|.||||||.||.|||.||||..||                     ||..||||||
iksaslstdkssldsaesdnkkaGttlngssasvilerertivstasdtevvlssGaiaeglsiinsPkgvgfdspgwmkfnhlynqnnfldeiriries

AGGSIIHYGTLRVNGLLSVSRSIGDKNLKEFIIPNPDSHIHNINKPNDQFLMIATDGLWEVFNHQDVVNEVLKLLQDKTIQK------DDISSIIVEEAI
.......||.|.||.||..|||.|||||||..|||.||......|.|||||..||||||||...||||.||..||.||..||      ..||..|||||.
lqaalynygellvnrllkksrskGdknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeav

KRNSKDNITLIIIFFNQ
||.|.|||||.||...|
krgsgDnitlviiklkq
0034914 PP2C-like 839-1146 5.6e-64 208.7 In-house 15-291 (295) alignment 
Range on Protein: 839-1146
Range on HMM: 15-291/295.0
NNGNKWFSVSIGETKGGRPHMEDNHVILEypyelyglekkksvdsiagansnsnnnnnnnnciSILS-SNEQFFFGVFDGHNGKIAAEYSRVNLPYEIFN
.  . ...|..  ..| |...|| ....                                   ..||  .....|||||||.|  |||. . .|......
sslllllrvgvasdqGrrksneDavlvvl..................................nllslledlllfgvfDGhgGhaaaevasellvellle

SFIKInkvgnSANNNNVDDLCLEAIKQGYLNTDKYFLDYAES--DNKKAGTTVATVILERERFIVSNAGDTEVVLCSGGIAEPLSIIHTPKLDTERIRIE
 . |.       .. . ..  .||.....|..|...|..|..  .    |||. .... .....| |.||. .||...| ...|.. |.|   .|| ||.
llekl.....lllltlsledieealrkaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelereril

SAGGSIIHygtLRVNGLLSVSRSIGDKNLK---------EFIIPNPDSHIHNINKPNDQFLMIATDGLWEVFNHQDVVNEVLKLLQdKTIQKDDISSIIV
|||| ..|    ||||.| |.|..|| .||          .... || ...... ..|.||..|.||||.|......|. | .||. |.   ....  .|
saggavsh...grvngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrslla.kgldleeaaeeLv

EEAIKRNSKDNITLIIIFFN
..|..|.|.|||| .....|
dlAlargsrDNiTvvvvrln
subfamily_PPM1E_pd Subfamily PPM1E 847-1147 5.2e-59 192.6 In-house 6-264 (265) alignment 
Range on Protein: 847-1147
Range on HMM: 6-264/265.0
VSIGETKGGRPHMEDNHVILEYPYELYGLekkksvdsiagansnsnnnnnnnncisiLSSNEQFFFGVFDGHNGKIAAEYSRVNLPYeifnSFIKINKV-
|||   |. | .||| ||.||   ||..|                              ..|. ||.||||| |  ||.|. ..|.       .. .|. 
vsiaavknkrrkmEDrhvaledlnelfel............................kdekeraffavfDGHgGveaakyaaahlhe....llvrqeklk

---GnsannnnvddlclEAIKQGYLNTDKYFLDYAESDNKKAGTTVATVILERERFIVSNAGDTEVVLCSGGIAEPLSIIHTPKLDTERIRIESAGGSII
                 ||.|... .||. ||  ||... |.|.|  .|..|.... |.  || ...|.. | |  |   | |. . |. |||.||| ..
edpa.............ealkeafkltDerflqkaereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvv

HYGTLRVNGLLSVSRSIGDKNLKEFIIPNPDSHIHNINKpNDQFLMIATDGLWEVFNHQDVVNEVLKLLQDKTIQKDDISSIIVEEAIKRNSKDNITLII
..|..|||| |||||.|||..||.... ..|    .... ....|..|.||||.|.|...||. | . |.|.. ......  .||.|....|.|||| ..
vigawRvnGvLsvsRaiGDvklkpyvsgeadvaeveldg.seeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvv

IFFNQ
.|...
vfldp
PP2Cc_SM00332 890-1143 7.9e-57 185.7 In-house 18-274 (274) alignment 
Range on Protein: 890-1143
Range on HMM: 18-274/274.0
NSNNNNNNNNCISIL---SSNEQFFFGVFDGHNGKIAAEYSRVNLPYEIFNSFIKINKVGnsannnnvDDLCLEAIKQGYLNTDKYFLDYAESDNK---K
  ......  .....   ....  ||||||||.|. .|.. . .||  . ..  | ..          .|   ||.|...|.||. .|. ..| ..   .
qgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel........eddveealkkaflstdeeileeeqskelenal

AGTTVATVILERERFIVSNAGDTEVVLCSGGIAEPLSIIHTPKLDTERIRIESAGGSIIHYgtlRVNGLLSVSRSIGDKNLK-------EFIIPNPDSHI
.|.|. ...| .|...|.|.|| ..|||..| | .||  |.|.  .|| ||..|||...     |||| |.|||..||. ||        .|.. || ..
sGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekg...rvngglavsrafGdhflkknkklkepyitaepdvkv

HNInKPNDQFLMIATDGLWEVFNHQDVVNEVLKLL-QDKTIQKDDISSIIVEEAIKR-NSKDNITLIII
... ...|.|| .|.||||.|...|.||. | ||| . || . ....  ..||||.| .|.|||| ...
vtl.tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
subfamily_PPM1A_pd Subfamily PPM1A 897-1146 4e-52 170.3 In-house 30-281 (282) alignment 
Range on Protein: 897-1146
Range on HMM: 30-281/282.0
NNNCISILSSNEQFFFGVFDGHNGKIAAEYSRVNLPYEIFNS--FIKinkvgnSANNNNVDDLCLEAIKQGYLNTDKYFLDYAESDN--KKAGTTVATVI
 .  .|. . ... || ||||| |. .|.|.  .|. .| ..  . .      .| ... .| ..||..||.|..|.   .  .. .  .|.|.|. ||.
htvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelke......aaleasekdevkealrqgfLaldeairelstdlktadksGsTavtvl

LERERFIVSNAGDTEVVLCSGGIAEPLSIIHTPKLDTERIRIESAGGSIIhygTLRVNGLLSVSRSIGDKNLKE---------FIIPNPDSHIHNINKPN
.. . .|. |.||.  |||..| |. |.  | |. ..|. ||| ||||..   . |||| | |||..||...||          ....|. .. .... .
vsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv...vsRvnGaLAvsRalGDyeykeeeekkaeeqlvsaepevtsierseed

DqFLMIATDGLWEVFNHQDVVNEVLKLLQDKtIQKDDISSIIVEEAIKRNSKDNITLIIIFFN
| ||..| ||.|.| . ..||. | | |. .  .   ... .|..|....|.||.......|.
d.flvlacDGiwDvlsdeevvelvrkrleva.deleevakalvdkalekgsrDNlsvlvvlfa
PP2C Protein phosphatase 2C 897-1138 1.2e-49 162.2 Pfam-A 25-255 (255) alignment 
Range on Protein: 897-1138
Range on HMM: 25-255/255.0
NNNCisiLSSNEQFFFGVFDGHNGKIAAEYSRVNLPyeifnSFIKINKVGNSANnnnvddLCLEAIKQGYLN-TDKYFLDYAES-DNKKAGTTVATVILE
....    . ..  ||.||||| |  ||.| | .|.      ..| .|  ....      .. .|.....|. ||. . . ...    | |.|  .... 
leks...sgkssvaffavfdghggreaakyarehle.....eilkeqksflele......kvekalrksfladtdeelksskantepsksGstavvalir

RERFIVSNAGDTEVVLCSGGIAE-PLSIIHTPKLDTERIRIESAGGSIIHygTLRVNGLLSVSRSIGDKNLKE----FIIPNPDSHIHNINKPnDQFLMI
 ....| |.||...|||... |.  |.  |.|. . || |||.||||...    |||| |.|||..||. ||.    .... ||.. .....  |.|| .
gkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvkltee.defliL

ATDGLWEVFNHQDVVNEVLKLLQDKTiQKDDISSIIVEEAIKRNSKDNI
|.||||.|...|..|  | . |..|. ......  .|.|||.|.|.|||
asdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 897-1138 1.2e-49 162.2 In-house 25-255 (255) alignment 
Range on Protein: 897-1138
Range on HMM: 25-255/255.0
NNNCisiLSSNEQFFFGVFDGHNGKIAAEYSRVNLPyeifnSFIKINKVGNSANnnnvddLCLEAIKQGYLN-TDKYFLDYAES-DNKKAGTTVATVILE
....    . ..  ||.||||| |  ||.| | .|.      ..| .|  ....      .. .|.....|. ||. . . ...    | |.|  .... 
leks...sgkssvaffavfdghggreaakyarehle.....eilkeqksflele......kvekalrksfladtdeelksskantepsksGstavvalir

RERFIVSNAGDTEVVLCSGGIAE-PLSIIHTPKLDTERIRIESAGGSIIHygTLRVNGLLSVSRSIGDKNLKE----FIIPNPDSHIHNINKPnDQFLMI
 ....| |.||...|||... |.  |.  |.|. . || |||.||||...    |||| |.|||..||. ||.    .... ||.. .....  |.|| .
gkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvkltee.defliL

ATDGLWEVFNHQDVVNEVLKLLQDKTiQKDDISSIIVEEAIKRNSKDNI
|.||||.|...|..|  | . |..|. ......  .|.|||.|.|.|||
asdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargsedni
subfamily_PPM1L_pd Subfamily PPM1L 905-1147 6.3e-47 153.1 In-house 31-268 (269) alignment 
Range on Protein: 905-1147
Range on HMM: 31-268/269.0
SSNEQFFFGVFDGHNGKIAAEYSRVNLPYEIFNSFIKINKVGNSANNNNVDdlclEAIKQGYLNTDKYFLDYAESDNKKAGTTVATVILERERFIVSNAG
 . .. ||.||||| |..|||...  |. .| | .|....  . .   | .    . ...  |  |. .|. |.. .. ||||.   ... . .||.| |
nktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfs....klltdeilsvdekllekakraediaGttalialvqesdlivanvG

DTEVVLCS-GGIAEPLSIIHTPKLDTERIRIESAGGSIIHYGTLRVNGLLSVSRSIGDKNLKE--FIIPNPDSHIHNINKPNDQFLMIATDGLWEVFNHQ
|.  ||.   |.| |||  | |.   || ||..||| |   |. ||.|.|..||..||  ||.  ..|..||    .... . .||..|.||||. |  .
dsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdiltfdlddhkpeflilasdGlwdtfsne

DVVNEVLKLLQDKTIQkddISSiIVEEAIKRNSKDNITLIIIFFNQ
. |. ... |..  .      | .| |. || | ||||.... ...
eavrfikerlkepdfG...aks.lvlesfkrGsvdnitvlvvklkn
PPM_PTC7 897-1138 9e-47 152.7 In-house 25-259 (259) alignment 
Range on Protein: 897-1138
Range on HMM: 25-259/259.0
NNNCisiLSSNEQFFFGVFDGHNGKIAAEYSRVNLPyeifnSFIKINKVGNSANnnnvddLCLEAIKQGYLN--TDKYFLDYAES-DNKKAGTTVATVIL
....    . ..  ||.||||| |  ||.| | .|.      ..| .|  .. .      .. .|.. ..|.  ||. . . ...   .. |.|  ....
less...sgkdsvaffavfdghggreaakyarehle.....eilkerksfeele......klekalrksflaldtdeelksseantepstsGstAvvali

ERERFIVSNAGDTEVVLCSGGIAE-PLSIIHTPKLDTERIRIESAGGSIIHYGTLRVNGLLSVSRSIGDKNLKE------FIIPNPDSHIHNINKPnDQF
  ....| |.||...|||..| |  .|.  |.| .  || |||.||||... |  |||| | |||..||. ||.       ... || . ..|..  |.|
tgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsaePdisstkidee.def

LMIATDGLWEVFNHQDVVNEVLKLLQDKtiQKDDISSIIVEEAIKRNSKDNI
| .|.||||.|...|..|  | . |..|  ......  .|.|||.|.|.|||
liLasdGlwdvvsdqeavdlvrselskk..dpmeaaeklvdeaiargsedni
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 907-1145 1.1e-44 145.7 In-house 35-253 (255) alignment 
Range on Protein: 907-1145
Range on HMM: 35-253/255.0
NEQFfFGVFDGHNGKIAAEYSRVNLpYEIFNSFIKINKVgnsaNnnnvddlCLEAIKQGYLNTDKYFldyaES-DnKKAGTTVATVILERERFIVSNAGD
.|.. . .|||| |. ||...  .| | |.......|.     |        ....|. | ...  .    .    |  ||| |.|.. ... ...| ||
dedy.yalfdGhgGraaakfaseel.ykilaelldlnna....n.......Pvkslkkaykeistqi....serp.kfiGttaasvliiedkvyianvGd

TEVVLC-SGGIAEPLSIIHTPKLDTERIRIESAGGSIIHY-GTLRVNGLLSVSRSIGDKNLKEFIIPNPDSHIHNINKPNDQFLMIATDGLWEVFNHQDV
. ||||   |.|. ||. | |. . |. ||. .|| ..    | |||| |.|||..||  |. |..|.|| .  . .. .|.||..| ||.|..   .. 
srvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeea

VNEVLKLlqdktIQKDDISSIIVEEAIKRNSKDNITLIIIFF
|. |..       . .. .  . . | .. |.|||..|.| .
veivagi.....sdpekaaeklrdlayssGstdnisvivikl
0049733 PP2C-like 850-1146 2.8e-43 140.9 In-house 8-234 (235) alignment 
Range on Protein: 850-1146
Range on HMM: 8-234/235.0
GETKGG-RPHMEDNHVIleypyelyglekkksvdsiagansnsnnnnnnnncisilssnEQFFFGVFDGHNGKIAAEYSRVNLPYEIFNSFIKinkvgns
   .|  |...|| ...                                          ....|.|.|||.|  |.|. . .|.  . . . .       
asdigrvrkvneDavlv..........................................glllfavaDGhgghaagevasellvetllellle.......

annnNVDDLCLEAIKQGYLNTDKYFLDYAES--DNKKAGTTVATVILERERFIVSNAGDTEVVLCSGGIAEPLSIIHTPKLDTERIRIESAGGSIihygt
          .||... .| .....|..|..  .    |||.....|  ....| |.||. ..|...| ...|.  |.|  ..|| ||..||| .     
....lllldleealrkaflaaneallelalaspelagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav.....

lRVNGLLSVSRSIGDKNLKefiipnPDSHIHNINKPNdqFLMIATDGLWEVFNHQDVVNEVLKllqdktIQKDDISSIIVEEAIKRNSKDNITLIIIFFN
 ||.| | ..|..||  ||      || ....... .  ||..|.||||.|......|. . .         ... . .||.|..|...||||.......
.rvpgrlaltralGdlllk......pdvtvlelepgd..flllasDGlwdvlsdeeivdllrs......ldleeaaerlvelalarggrDNiTvvvvrld
subfamily_PPM1G2_pd Subfamily PPM1G2 845-1145 4.2e-42 137.0 In-house 19-286 (287) alignment 
Range on Protein: 845-1145
Range on HMM: 19-286/287.0
FSVSIGETKGGRPHMEDNHVILEYpyelyglekkksvdsiagansnsnnnnnnnnCISILSSNEQFFFGVFDGHNGKIAAEYSRVNLPYEIFNsfikink
. |.    .| | .||| |.. .                                 ..   ...  .|.||||| |. .|.|.  .|   | .       
tkvgssamqGyrlnmeDahilene...............................lleksddkslalfavfDGhGGakvakyagkklikkiak.......

vgnsaNNNNVDDLCLEAIKQGYLNTDKYFLDYAESDNKKAGTTVATVILERERFIVSNAGDTEVVLCSGGIAEPLSIIHTPKLDTERIRIESAGGSIihy
     ...  ..   ...|...|.||. .|   . ....||.|  .|... |...|.||||   ||.| | .. ||. | |.  .|..||. ||| .   
.....kksfkegaleqilkdafletDeellkdeklkdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfv...

GTLRVNGLLSVSRSIGDKNLKEFI---------IPNPDSHIHNINkPNDQFLMIATDGLWEVFNHQDVVNEVLKLLQDKtIQKDDISSIIVEEAIKRNSK
   |||| |..||..|| . |.              ||  ..... ..| ||..| ||.|.|.. ..||. | . |...  . |.|.. .........|.
elnrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsg.akldeiieelldkclapdss

------DNITLIIIFF
      ||.|..|. .
ntgvGcDnmtvvivvl
subfamily_PPM1K_pd Subfamily PPM1K 886-1146 1.3e-36 119.1 In-house 7-259 (263) alignment 
Range on Protein: 886-1146
Range on HMM: 7-259/263.0
GANSNSNNNNNNNNCISILSSN-EQFFFGVFDGHNGKIAAEYSRVNLPYEIfNSFIkinkvGNSANNNNVDDLCLEAIKQGYlNTDKYfLDYAESDNKKA
| .|     ..|.. |...  . | ....||||| |  ||..   .|   . . .       .  . . |    .| ... . .   . . .||.. ...
GkdsliGkraenedriklkeldpellyvavfdGhaGsaaadfvhdklekil.krll.....ekekdleivlknafeeldkkl.kryle.fsvaeaellss

GTTvATVILERE--RFIVSNAGDTEVVLCSGGIAEPLSIIHTPKLDTERIRIESAGGSIIH--YGTLRVNGLLSVSRSIGDKNLKEF-IIPNPDSHIHNI
||| ||| | |.   ..... ||.  .||  | |. |.. |.|.|..|. || .||||.     | ..||| |...||.|| .||.. .| .|...  ..
Gtt.atvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkv

NKPNDQFLMIATDGLWEVFNHQDVVNEVlKLLQDktiqKDDISSIIVEEAIKRNSKDNITLIIIFFN
.. .| ||.. |||.  | | |.. . | .| .|     .. .. ..| |..  |.|| | ... ..
dhaadsflvlitdgisfvvnsqelcdlv.rlchd....peeaahalteqalqygsednatavvvplg
subfamily_ILKAP_pd Subfamily ILKAP 908-1143 1.5e-36 119.1 In-house 42-290 (293) alignment 
Range on Protein: 908-1143
Range on HMM: 42-290/293.0
EQFFFGVFDGHNGKIAAEYSRVNLPYEIFNSFIKiNKVGNSAnnNNVDdlclEAIKQGYLNTDKYFLDYAESDN--KKAGTTVATVILERERFIVSNAGD
   ...||||| |. |.|..  .|  .| . . | ..| .    ...      .. . . .||. ||  |....   | |.|...|.   . . |.| ||
rvsyyavfdGhaGsrasefaaeklhkkileklpk.sdvsake..keik....kclvdsfkktdeefLklaskakPvWkdGstatvvlvldnvlyvanlGd

TEVVLCSGG------IAEPLSIIHTPKLDTERIRIESAGGSIIHyGtlRVNGLLSVSRSIGDKNLKEF-IIPNPDSHIHNINkPNDQFLMIATDGLWEVF
.  ||.         .. .|.  |||    || ||. |||.. . |  ||.|.| ||||||| . |.  .| .|| .  ... .||.|...| ||||.||
skavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrd.g..rvlGvlevsrsiGdgrfkrlGvistPdvkkceLt.endlfvvlaCdGLwkvf

NHQDVVNEVLKLLQDK----TIQK------DDI-----SSIIVEEAIKRNSKDNITLIII
. ..||. .||.|.|.    .|..      ...     .  .  ||.||.| ||.| ...
sadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllv
subfamily_PPM1D_pd Subfamily PPM1D 848-1146 4.2e-33 107.8 In-house 5-308 (309) alignment 
Range on Protein: 848-1146
Range on HMM: 5-308/309.0
SIGETKGGRPHMEDNHVILEYPYELYGlEKkksvdsiagansnsnnnnnnnncisilssnEQFFFGVFDGHNGKIAAEYSRVNLpyeifNSFIKINKVGN
.   ..|||..|||  .|   . |    |.                              |. |..||||| || ||.. | .|      |.|| .|   
tseadqGgrkymeDvvaivleeeesae.el..............................evafvavfDGHGGkeAakfarehl.....wsvikkqkkfl

SANNNNVddlcLEAIKQGYLNTDKYFLDYAES-------DNKKAGTTVATVILERERFIVSNAGDTEVVLCSGGI------AEPLSIIHTPKLDTERIRI
| ....|    ||||....|.| .      |.       .   ||||...||. ||.. |.. || ..|| .         |..|   | |.  .|. ||
ssepedv....leAireaflatheamkkkleeWpktksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekeri

ESAGGSIIHY-GTLRV---------NG--------LLSVSRSIGD-----KNLKEFII-PNPDSHIHNINKPNDQFLMIATDGLWEVFNHQDVVNEVLKL
|..||.. .  |  ||         ||         |.|.||.||     .. .||.. |.||   ....  ...|...|.||||.| . .|.|. | | 
eelGGevaaksGvkRvvWkRprlehngptvideiPFLavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvveke

LQDKTI---QKDDISSIIVEEAIKRNSK-----DNITLIIIFFN
 . |..   |. .... .|.||..| ..     ||...|.....
eekkelkeeqsrsvakalvkealqrwrskklraDnvsvivvile
subfamily_PPM1G_pd Subfamily PPM1G 975-1125 3.3e-29 95.2 In-house 287-441 (473) alignment 
Range on Protein: 975-1125
Range on HMM: 287-441/473.0
DYAESDNKKAGTTVATVILERERFIVSNAGDTEVVLCSGGIAEPLSIIHTPKLDTERIRIESAGGSIIHYGtlRVNGLLSVSRSIGDKNLKE--------
...|.  ...|||   ..|. .. || ||||.  ||.. | |  ||. | |. ..|. ||| ||| . . |  |||| | .|| .|| . |.        
eekeepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedg..RvnGGLnlsRAlGDhaYkkneeLplke

-FIIPNPDSHIHNINkPNDQFLMIATDGLWEVFNHQDVVNEVLKLLQDKTIQkdDISSII
  |   || ... .  ..|.||..|.||.| | . |.||. | . |.... .   .|.|.
qmisAlPDikvltlt.eedeFlvlAcDGiWnvmesqevvdfvraklkkgees..vlseiv
subfamily_KAPP-like_pd Subfamily KAPP-like 910-1143 6.1e-27 87.3 In-house 35-264 (266) alignment 
Range on Protein: 910-1143
Range on HMM: 35-264/266.0
FFFGVFDGHNGKIAAEYSRVNLPYEIfNSFIKINKVGNS-ANNNNVDDLCLEAIKqgylNTDKYFLDYaesDNKKAGTTVATVILE-RERFIV-SNAGDT
 .|.||||| || ||. ..  .| |. .  .|  |  .   |. .  .| ..|.|    . |. . |.   . . | .|.| |  . . |..  .| ||.
alfavfdGhaGkGaadaakklfpkel.ekllkstkqddGGdniydqskllenafk....evdaklkdf...eyeGatatlalvwsdGqqrylqvanvGds

EVVLCSGGIAEPLSIIHTPKLDTERIRIESAGGSIIHyGTLRVNGLlSVSRSIGDKNLKEFIIP-NPDSHIHN--INKPNDQFLMIATDGLWEVFNHQDV
   |. |  .  ||  |  | . |. ||   | .. . .  |.|||  |||..||. .||  |    . .. |  .  | |.||..|.||||.| . .| 
saflsrGneslelskdhkakdpeekqrikddGitlsd.nqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkda

VNEVlKLLQDKTIQKDDISSIIVEEAIKR-NSKDNITLIII
.. | | | |.   .|...| ..| ||.   .|||...|..
iekv.kslydqqatedkmasslletaiqsikakdnvsvivv
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 910-1143 1.9e-24 79.0 In-house 34-274 (276) alignment 
Range on Protein: 910-1143
Range on HMM: 34-274/276.0
FFFGVFDGHNGKIAAEYSRVNLPYEIfNSFIKINKVGNSANNNNVDDLC--LEAIKQGYLNTDKYFLDYaesDNKKAGTTVATVILE-------RERFI-
 .|.||||| || ||. ..  .| |. . ..|  .   . ...  |.     . ... . . |. . |.   . . | .|.| |  .       ..|.. 
alfavfdGhaGkGaadaakklfpkel.ekllksgnysltkqddGGdniydqskllldlfkevdaklkdf...eyeGatatlalvwsdGeeqqqqqqrylq

VSNAGDTEVVLCSGGIAEPLSIIHTPKLDTERIRIESAGGSIIHyGTLRVNGLlSVSRSIGDKNLKEFIIP-NPDSHIHN--INKPNDQFLMIATDGLWE
|.| ||.   |. |  .  ||  |  .   |. ||   | .. . .  |.|||  |||..||. .||  |    . .. |  .  | |.||..|.||||.
vanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsd.nqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwd

VFNHQDVVNEVlKLLQDKTIQKDDISSIIVEEAIKR-NSKDNITLIII
| . .| .. | | | |.   .|...| ..| ||.   .|||...|..
visGkdaiekv.kslydqqatedkmasslletaiqsikakdnvsvivv
subfamily_PP2D1_pd Subfamily PP2D1 998-1121 2.7e-24 78.7 In-house 190-318 (492) alignment 
Range on Protein: 998-1121
Range on HMM: 190-318/492.0
FIVSNAGDTEVVLCSGGIAEPLSIIHTPKLDTERIRIESAGGSIIHYGT-LRVNGLLSVSRS---IGDKNLKEFIIPNPDSHIHNINKpNDQFLMIATDG
  ..|||... ||| .| |  |   |||.   || |.| ||...   .   .|||.|.. |    .|| .||. .||.|  .  .... ..|||..|. |
lyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvklde.aaqflvlAsnG

LWEVFNHQDVVNEVLKLLQ--DKTIQKDDI
||||.....|.. | ..|.   . .... .
lWevlseeevlsLvkqtlaiyksrvraenv
PPM_PTC7_SpoIIE 904-1126 7.1e-21 68.1 In-house 29-227 (230) alignment 
Range on Protein: 904-1126
Range on HMM: 29-227/230.0
LSSNEQFFFGVFDGHNGKIAAEYSRVNlpyeifnSFIKINKvGNSANnnnvddLCLEAIKQGYLN----TDKYfldyaesdNKKAGTTVATVILERER--
   .  ...|..||| |  |.  ....       .... ..  ....      .  |... ..|.    ....        ... |.|.  .... ..  
sggrlalvvgdvdGhGgraalamgllr.......talrela.fagle......kpeeilrrlnlalaadlede........psssgaTavvalidpstgk

FIVSNAGDTEVVLCSG-GIaeplsiihtpkldtERIRIeSAGGSI-IHYGTLRVNGLLSVSRSIGDKNLKE---FIIPNPDsHIHNINKPNDQFLMIATD
. |.||||  ..|... |               ||.||  ||| . .  .  ||.| |.||...||. |.     . . || ..... . .|.|| .|.|
lyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvveaepd.tsdgelfgkdeflilasd

GLWEVFNHQDVVNEVLKLLQD---KTIQKDDISSIIV
|||.| . |..|  |.. | .   . ...|||. ..|
glwdvlspqelvdlvrdelekpaaeglleDDitllvv
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 893-1078 2.1e-13 43.5 In-house 5-200 (292) alignment 
Range on Protein: 893-1078
Range on HMM: 5-200/292.0
NNNNNNNCISILSSNEQFFFGVFDGHN--GKIAAEYSRVNLPYEIFNSFIKINKVGNSANNNNVdDlcleaikqGYLNTDKYFLDyaesDNKKAGTTVAT
 .|... ..   |.   |.  |.|||   |.  |...  .| .|. ... .  .. ..  .. . |           . || ..|     ...|.|.|  
kenqdrfllvegsealtflaavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllril.d........iaakldkltid....aresattavvc

VILERE-RFIVSNAGDTEVVLCS--GGI---AEPLSIIHTPKLDTERIRIESAGGSII--------HYGTLRV------NGLLSVSRSIGDKNLKEF-II
 .   . ..|..| ||....|    ||      |||  | |.   || ||  ||| .         . || ||      .| |..||..||  |.|  ..
arvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvv

PNPDSHIHN
 .|. .|| 
aePelqiha
PP2C_SIG_SM00331 903-1144 3.4e-12 39.4 In-house 23-216 (217) alignment 
Range on Protein: 903-1144
Range on HMM: 23-216/217.0
ILSSNE-QFFFGVFDGHN-GKIAAEYSRVNLPYeiFNSFIKINkvgnsannnnvddlclEAIKQ-----------GylntdkyfldyaeSDNKKAGTTVA
... || .... |.||.  |. ||..|.  ..   .  ... .                |...|                         ...|  ..|. 
vvklnegrlllvvaDgmGkGlaAaaassqlrta..lrellseg................eelsqalkrlnraiyee.............keekgmfaTll

TVI--LERERFIVSNAGDTEVVLCS-GGIAEPLSIihtpkldteririesaggsiihygtlrvngllSVSRSI------GdknlkefiipnPDSHIHNIN
  .  ... .. . ||||  ..|   |.  |.|.                                   .. .                  .|..  ...
lalydfssgklsyanaGdsrpyllrdgklveilkd................................vegaplGlepevs...........vdirelele

KpnDQFLMIATDGLWEVF-----NHQDVVNEVLKLLQDKTIQKDD-ISSIIVEEAIKRNSKDNITLIIIF
|  . .|...||||.|.      . ... . . .|...   . .. |   ..|.|  .| .|.||.....
k..gdllllytDGltearsekgfaeerleeiledlvdseaqelaqkiveellelakgsngeDdiTvvvvk
PPM_PTC7_motif 1089-1138 9.3e-10 31.9 In-house 2-51 (51) alignment 
Range on Protein: 1089-1138
Range on HMM: 2-51/51.0
IATDGLWEVFNHQDVVNEVLKLLQDKTIQKDDISSIIVEEAIKRNSKDNI
.|.||||.|...|..|. | . | .|  .   ... .|.||..|.|.|||
LAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
subfamily_PDP_pd Subfamily PDP 1072-1118 5.4e-09 28.6 In-house 274-319 (398) alignment 
Range on Protein: 1072-1118
Range on HMM: 274-319/398.0
PDSHIHNInKPNDQFLMIATDGLWEVFNHQDVVNEVLKLLQDKTIQK
|.   |.. ..||.||..||||||.......||. | . |..|. ..
Pevtshkl.rendkFLvlatDGLwdllsneevvslVgehlakkkeke
subfamily_PHLPP_pd Subfamily PHLPP 1000-1109 1.9e-08 26.5 In-house 109-214 (246) alignment 
Range on Protein: 1000-1109
Range on HMM: 109-214/246.0
VSNAGDTEVVLCSGGIaePLSIIHTPKLDTE-RIRIESAGGSIIHygTLRVNGLLSVSRSIGDKNLKEFIIPNPdsHIHNIN-KPNDQFLMIATDGLWEV
| . |  . ||. .|   .| . .. .....   ||  | . |      ..||... .| .|   |  ...|.|  |....  ...| .|..  . ||||
vAsvGtlqavliRngk..klrlsksyviekdelkrikeakaiite..dnkingviestrllGytflfPvvlPkp..hvrevlLteqdellivGnkalWev

FNHQDVVNEVLK
.. ...|..| |
lsideaveavrk
subfamily_TAB1_pd Subfamily TAB1 891-967 4.8e-08 25.2 In-house 9-83 (333) alignment 
Range on Protein: 891-967
Range on HMM: 9-83/333.0
SNNNNNNNNCISILSSNEQFFFGVFDGHNGKIAAEYSRVNLPYEIFNSFikINKVGNSANNNNVDDLCLEAIKQGYL
........... . . |... ..||||..|. ||..   .|..|...    ...  ..|. ..|    .|......|
kedhevedkvflfktendpilyavFdGydGnkaakfveqrLvaellleq..ltdelaeaevkevlkrafeeverkfl
subfamily_PPM1H_pd Subfamily PPM1H 952-1033 1.1e-07 24.0 In-house 130-211 (404) alignment 
Range on Protein: 952-1033
Range on HMM: 130-211/404.0
NNVDDLCLEAIKQGYLNTDKYFLDYAESDNKKAGTTVATVILERERFIVSNAGDTEVVLCSGGIAEPLSIIHTPKLDTERIR
 . ..| . |. . .|. |.      |. ..| | |.  ...  ... |.||||.  .|.  .   |||  .||. . .|..
iskeeLviGalesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPeteRqRlq
subfamily_PPM1H_pd Subfamily PPM1H 1054-1118 1.5e-07 23.5 In-house 282-358 (404) alignment 
Range on Protein: 1054-1118
Range on HMM: 282-358/404.0
SVSRSIGDK---------NLKEFIIPNPDSHIHNIN---KPNDQFLMIATDGLWEVFNHQDVVNEVLKLLQDKTIQK
.|.| .||          ..| |. | |. .. ...   . .|. |..||||||.| . ..| . | ..|.. . . 
gvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskveped
PPM_PTC7_SpoIIE_motif 1083-1143 1e-06 22.3 In-house 11-78 (81) alignment 
Range on Protein: 1083-1143
Range on HMM: 11-78/81.0
NDQFLMIATDGLWEVFNHQDVV---NEVLKLLQDK---TiqKDDISSIIVEEAIKRN---SKDNITLIII
..  |...||||.|  . .. .    |.|.|...    .   ....  .|.|.....   ..|.|||...
pgdvllLyTDGltEardsdgelfgkeellrladraegks..lqeladklvdevlengsgereDDitllvl
subfamily_PDP_pd Subfamily PDP 890-961 1.6e-06 20.4 In-house 6-77 (398) alignment 
Range on Protein: 890-961
Range on HMM: 6-77/398.0
NSNNNNNNNNCISILSSNEQFFFGVFDGHNGKIAAEYSRVNLPYEIFNSFIKINKVGNSANNNNVDDLCLEA
.||. .  .. .. | ... ..||||||| |. .||  . .|.. .  | .| ... .. .. . .. .|. 
asNePiEDrrseakllesngvlfgvfDGHggaacaeavskrLlkyvaasllkkqvleeaekalesgkallkl