Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_PPTC7_pd | Subfamily PPTC7 | 170-388 | 2.7e-81 | 265.7 | In-house | 5-251 (252) | alignment | ||
Range on Protein: 170-388
Range on HMM: 5-251/252.0
GKQQGICEDSHFLS--KDFTTIGVADGVGSWRSVGIDPGEYSRFLMSFIYGQSLTTPY--LKPYELIESAYRESVNIP----GSSTICILKIIGS--KVY
||.| ..||..|.| |.....|||||||.||||||||.|.||.||.... .| .. . |||.||.|.||.|... . ||||.||... .| |..
gkrqkageDayfvsseksadvlgvADGVggWrsvGiDpsefsreLmkaceklskeskaeelkPvelleaayqelleekvpvlGssTacivvldksdkkle
SGLVGDSSFIQIRKDQIYFRSNEQTHKPNFPYQL--------GQNSVDKPSSGVYMEHPIQENDIFVIGTDGFFDNIFDQEIVKAIKEVN-----SIESF
| .|||.|...||....|||.||.||.|.|||| |....|||.............||.|..|||.|||....||....||.. |..|.
sanlGDSgflvvRkgkvvfrskeqqhkfntPyQLsiapegregkvildkpeaadsksfavkkgDiivlatDGlfDNlledeileilkelkeseksslqsl
FKCLMELAKSKSQDPEAQTPIGQRNGKI-----GGKNDDITVGCFVI
.|.|.| |...|.|||...|..|...| |||.||||| ..|.
akklaekarelsldpeyespfaqkakkngleasGGKpDDitvvvavv
|
|||||||||
0049733 | PP2C-like | 167-385 | 6.6e-30 | 97.3 | In-house | 9-230 (235) | alignment | ||
Range on Protein: 167-385
Range on HMM: 9-230/235.0
NSVGKQQGICEDSHFLskDFTTIGVADGVGSWRSVGIDPGEYSRFLMSFIYGqsltTPYLKPYELIESAYRES------------VNIPGSSTICILKII
.|... ..||.... ... ..||||.|... .. . . ..|...... ...|.. |....|... . .|.... ..
sdigrvrkvneDavlv..glllfavaDGhgghaagevasellvetllellle....lllldleealrkaflaaneallelalaspelagmgtTavvalld
GSKVYSGLVGDSSFIQIRKDQIYFRSNEQTHKPNFPYQ--------------------LGqN-SVDkpssGVYMEHPIQENDIFVIGTDGFFDNIFDQEI
|.|.| |||| .. .|........ .... ....| || . .. .........|.... .||..|.. |.||
ggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggavrvpgrlaltralG.dlllk....pdvtvlelepgdflllasDGlwdvlsdeei
VKAIKEvNSIESFFKCLMELAKSksqdpeaqtpigqrngkiGGKNDDITVGC
|. ... ...| ..|.||| . .|. |.||| .
vdllrs.ldleeaaerlvelala..................rggrDNiTvvv
|
|||||||||
0034914 | PP2C-like | 145-388 | 1.7e-25 | 82.7 | In-house | 5-290 (295) | alignment | ||
Range on Protein: 145-388
Range on HMM: 5-290/295.0
SNPNYEIIVQNSTKKFYFKGMINSVGKqQGICEDSHFL-------SKDFTTIGVADGVGSWRSVGIDPGEYSRFLMSFIYGQ--SLTTPYLKPYELIESA
|.|..|.. .| . .. |. .|. .||... .|.. .||.||.|... . . ..|.... . .||... . | ...|
slpllellllsslllllrvgvasdqGr.rksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrka
YRES------------VNIPGSSTICILKIIGSKVYSGLVGDSSFIQIRKDQIYFRSNEQTHKPNFPYQ-----------------------LGQNSVD-
. . . ...|.... |.|.|.| . |||| .. .|...... ...... . .. || .
flaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlkl
-------------KPSSGvYMEHPIQENDIFVIGTDGFFDNIFDQEIVKAIKE----VNSIESFFKCLMELAKSksqdpeaqtpigqrngkiGGKNDDIT
| ..| ....|......||..|.. ..|||. ... ...| . |..|| . .|. |.||
llslllleplvsaePdvt.vleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla..................rgsrDNiT
VGCFVI
| . .
vvvvrl
|
|||||||||
PP2C_SIG_SM00331 | 183-383 | 6.1e-08 | 25.5 | In-house | 27-212 (217) | alignment | |||
Range on Protein: 183-383
Range on HMM: 27-212/217.0
SKDFTTIGVADGVGswrsVGIDPGEYSRFLMSFIYGQSLT--TPYLKPYELIESAYRESVNIPGSSTICILKI--IGSKVYSGLVGDSSFIQIRKDQIYF
... . . ||||.| |.. ...|. | . . .. .. . .|.. .|.|... . |...... ..|.. .||| .. .|... .
negrlllvvaDgmG....kGlaAaaassqlrtalrellsegeelsqalkrlnraiyeekeekgmfaTlllalydfssgklsyanaGdsrpyllrdgklve
RSNEqthkpNFPYQLGQNSVDKpssGVYMEHPIQENDIFVIGTDGFFDNIFD--------QEIVKAI--KEVNSIES-FFKCLMELAKSKSQdpeaqtpi
. . . ...|| . . | ... |.... ||| ... . .||... |. . . ....|.|||| . .
ilkd.....vegaplGlepevs...vdirelelekgdllllytDGltearsekgfaeerleeiledlvdseaqelaqkiveellelakgsng........
gqrngkiggkNDDITV
.|||||
..........eDdiTv
|
|||||||||
PP2Cc_SM00332 | 309-384 | 2e-06 | 20.4 | In-house | 208-272 (274) | alignment | |||
Range on Protein: 309-384
Range on HMM: 208-272/274.0
HPIQENDIFVIGTDGFFDNIFDQEIVKAIKEVN------SIESFFKCLMELAKSKsqdpeaqtpigqrngkiGGKNDDITVG
.|...... .|| .|.. .||.|. ... . . . . |.|.| .. ||..|.|||
tltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairr.................ggseDniTvv
|