Gene CG10592 in Drosophila melanogaster

Synonym: Dmel\CG10592, Dmel_CG10592, CG10592

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold AP
Superfamily AP
Family AP
Subfamily AP
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP002_AA protein Get Run
DmelP002_AA_45-516 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_AP_pd Subfamily AP 49-516 2.1e-193 633.9 In-house 3-469 (472) alignment 
Range on Protein: 49-516
Range on HMM: 3-469/472.0
TRFWHDKAQSILADKLAGHkkLNENRAKNVILFLGDGMSVHTIAATRAFMGD------SNKQVFFEKFPYLGLSKTYAVNERTPDSANTATAYLTGVKAN
..||..|||. |...|. .   |...||||||||||||.|.|..|.| ..|.      ..... .|.|||.||||||.... .|||| ||||||.|||.|
akfwlkkaqeelkealelq..snskkakNvilflgdGmgvstvtaaRilkgqlkgelgeeasLaleeFpyvglsktyssdkqvpdsaatAtAylcGvktn

YGTIGVNAQVQRGDCVTNSSSHVQSIGQWAQEAGKWAGLVTTARVTHASPAGVYAHVSERNWEHDGEIiSSKCSPDVNTDIARQLVEWPVGQELRVIMGG
.|||||.|.|.|.|| ......|.|| ..|..|||..|||||.|||||||||.||||..||||.| |. .......  .|||.||.|..||.||.||.||
ngtiGvdaaverkdCeasagkevdsileaAkkaGkatGlVtttrvthAsPaglyahvanRnwesdeev.paeaekegckdiaqQLieeevgkeldvilGG

GRSYFRDQSQHDETGVS-GLRTDGRDLISDWreikKQQGAEGKYVWSLKGLKETDISKTDYLLGLFDTSHLPYHGDRrrthYEDAEPSLSDMTEAAIKML
||..| .....|... . | |.|||.||..|    ... .. |||.. | |...| ||||.|||||..|||.|. ||     |..||||..|||.|...|
GrkkflpktvkdseyekkgerkDgrnLieew....ekekknakyvenrkelenvdksktdrllGlfadshlkyeidr....dekeePsLkemtekAlevL

SKNEEGYFLFVESGRIDMAHHATKAMKALEDTEEFAAAVELARKMTDEEDTLIVVTSDHSHTMSINGYPYRRQNILSLAP-NLADDELPFTILSYANGPG
||||.|.|||||.||||.|||..||.||||.| || .|||||...|||||||||||.|||||..|.|||.|...||.||. . ..||||.|.||||||||
sknenGffLfVEggrIDhahhenkakkaleetlefdeavelaleltdeedTlivvtaDHshtltiagypkrgssilglakesksadelpyttlsyangpg

FDDTYSTK--DGRIDLSHADTTSAEFEFQATVPLSSETHGAEDVGVFASGPFEHLFTGNYEQSAIPAMMAYAANIGPF
...|.|..  . | ||..|.|.. ....||.|||..||||.|||.|.|||| .||.||..||| |...|||||..|. 
yeltesdleegerkdlteaeteakdyvsqaavpleeetHggeDvavyasGpqshlltGvveqstiahvmayaaclgea
0037220 Alkaline phosphatase-like 46-516 9.7e-151 492.8 In-house 6-471 (479) alignment 
Range on Protein: 46-516
Range on HMM: 6-471/479.0
ELDTRFWHDKAQSILADKLagHKKLNENRAKNVILFLGDGMSVHTIAATRAFMG------DSNKQVFFEKFPYLGLSKTYAVNERTPDSANTATAYLTGV
.|.. ...  |. .|.  |  . .||...|||||||.||||.|.|..|.| ..|      . ... ...|||..||.|||.|.. ..|||..|||..|||
llllllllllalallllal..llllnkskaknvilfigDGmgvstvtaariylgqllgglgeegllaldkfplvglvkTysvdslvtDSAaaaTAlatGv

KANYGTIGVNAQVQRGDCVTNSSSHVQSIGQWAQEAGKWAGLVTTARVTHASPAGVYAHVSERNWEHDGEIISSKCSPDvNTDIARQLVewpVGQELRVI
|.|.|.|||.|.|.|..| .. ...|..| ..|.||||. |||||.|.|||.||..|||| .||||.| ..   .....  .|||.|||   .|. | ||
KtnngaigvdadvsrdncddplgnpvetilelakeaGkatGlVtTtrithATPAafyAhvanRnweddialqllgleag.ckdiatqlv...lgsgldvi

MGGGRSYFRDQSQHDETGV-----SGLRTDGRDLISDWREIKKQqgaeGKYVWSLKGLKETDI-SKTDYLLGLFDTSHLPYHGDRrrthYEDAEPSLSDM
.||||.|| .....|...      .| |.|||||.. ..|.||.      ||.....| . |. |..|.|||||..|||||. ||      . ||||..|
lGGGrkyflpkgtldpeydlelllggkrldgrdlleeakekkkg....ytyvtnreeldaldlgsnvdkllGlfadshlpyeldr....daseePsLaem

TEAAIKMLSKNEEGYFLFVESGRIDMAHHATKAMKALEDTEEFAAAVELARKMTDEEDTLIVVTSDHSHTMSINGYPYRRQNILSLAPNLADDELPFTIL
||.|...||||..|.||.||.||||.|.||..|. ||.....|  |||.|.......|||.|||.||||...|.||..| . || |.|.|. | ||.| |
tekAldlLskndkGFfLmvEggriDhagHandaaaalgevlafdeaveaalefakdddTlvvvtADHshgglilgyadrgnpilgllpgllldglpyttl

SYANGPGFDDTYSTkdgRIDLSHADTTSAEFEFQATVPLSSETHGAEDVGVFASGPFEHLFTGNYEQSAIPAMMAYAANIGPF
.|||||||  ....   |.||....|..  . ..|.|...|..|..||| |.|.|| ..||.|.||.. |. ..|.|...|..
lyangpgflllldl...rldltllvtlallllqralvgwtsggHtgedVpvyayGpgaelflgvyentdiahviasalglgll
Alk_phosphatase Alkaline phosphatase 75-512 1e-130 427.0 Pfam-A 1-420 (421) alignment 
Range on Protein: 75-512
Range on HMM: 1-420/421.0
AKNVILFLGDGMSVHTIAATRAFMGDSNKQ-----VFFEKFPYLGLSKTYAVNERTPDSANTATAYLTGVKANYGTIGVNaqvqrgdcvtNSSSHVQSIG
||||||..||||.| |..|.| . .. ...     . ....|..||||||||... .||| |||||..|||.. |.|||.          .  ..|.|. 
aknvilligDGmgvstvtaaRslkeqakgklgeeilaldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd..........thgkevksvl

QWAQEAGKWAGLVTTARVTHASPAGVYAHVSERNWEHDGEIiSSKCSPDVNTDIARQLVEWPvgQELRVIMGGGRSYFRDQSQHDETGVSGLRTDGRDLI
..|..|||  |||||.|||||.||...|||..|.|| | .  ...   . . ||| ||.. .  ... |..||||..| .....||.. .|.|.|||.||
eaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaat.aasakkeGkkdiaeqlikak..kkidvllGGGrkeflptgtkdeekerGtrldgrnli

SDWreikKQQGAegKYVWSLKGLKETDISK-TDYLLGLFDTSHLPYHGDRRrthyEDAEPSLSDMTEAAIKMLSKNEEGYFLFVESGRIDMAHHATKAMK
 ..    |..|.  .||.  | |...  .. ...|||||. ..|... .|.    |. ||||..|||.|||.|||||.|.||.|| .||| |.|...|..
eea....kkagy..qyvsdrkeLlkakeensvkplLGLFadgdlkvelerd....ekeePsLkemtevAiklLsknekGFFLlVEGsrIDhaaHendavg

ALEDTEEFAAAVELARKMT-DEEDTLIVVTSDHSHTMSINGYPYRRQNILSLAPNLA-DDELPFTILSYANGPGFDDTYstkDGRIDLSHADTTSAEFEF
||... ||  ||. | ...  |..||.|||.||||..||.||. | ..| .||. .. .|  ......|.||.| . .    . | ... ..... ....
alsEvvefdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaakktkdgkakklilygngegakved...garenvtaeealekiyrk

QATVPLSSETHGAEDVGVFASGPFEHLFTGNYEQSAIPAMMAYAAN
.. |.|.||.|..||| ||| || ..|..|..||  |. ..|.|..
rsavgltseeHtgedvavfAygpkaelvrGvqeqteiakvlaaale
Alk_phosphatase Alkaline phosphatase 75-512 1e-130 427.0 In-house 1-420 (421) alignment 
Range on Protein: 75-512
Range on HMM: 1-420/421.0
AKNVILFLGDGMSVHTIAATRAFMGDSNKQ-----VFFEKFPYLGLSKTYAVNERTPDSANTATAYLTGVKANYGTIGVNaqvqrgdcvtNSSSHVQSIG
||||||..||||.| |..|.| . .. ...     . ....|..||||||||... .||| |||||..|||.. |.|||.          .  ..|.|. 
aknvilligDGmgvstvtaaRslkeqakgklgeeilaldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd..........thgkevksvl

QWAQEAGKWAGLVTTARVTHASPAGVYAHVSERNWEHDGEIiSSKCSPDVNTDIARQLVEWPvgQELRVIMGGGRSYFRDQSQHDETGVSGLRTDGRDLI
..|..|||  |||||.|||||.||...|||..|.|| | .  ...   . . ||| ||.. .  ... |..||||..| .....||.. .|.|.|||.||
eaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaat.aasakkeGkkdiaeqlikak..kkidvllGGGrkeflptgtkdeekerGtrldgrnli

SDWreikKQQGAegKYVWSLKGLKETDISK-TDYLLGLFDTSHLPYHGDRRrthyEDAEPSLSDMTEAAIKMLSKNEEGYFLFVESGRIDMAHHATKAMK
 ..    |..|.  .||.  | |...  .. ...|||||. ..|... .|.    |. ||||..|||.|||.|||||.|.||.|| .||| |.|...|..
eea....kkagy..qyvsdrkeLlkakeensvkplLGLFadgdlkvelerd....ekeePsLkemtevAiklLsknekGFFLlVEGsrIDhaaHendavg

ALEDTEEFAAAVELARKMT-DEEDTLIVVTSDHSHTMSINGYPYRRQNILSLAPNLA-DDELPFTILSYANGPGFDDTYstkDGRIDLSHADTTSAEFEF
||... ||  ||. | ...  |..||.|||.||||..||.||. | ..| .||. .. .|  ......|.||.| . .    . | ... ..... ....
alsEvvefdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaakktkdgkakklilygngegakved...garenvtaeealekiyrk

QATVPLSSETHGAEDVGVFASGPFEHLFTGNYEQSAIPAMMAYAAN
.. |.|.||.|..||| ||| || ..|..|..||  |. ..|.|..
rsavgltseeHtgedvavfAygpkaelvrGvqeqteiakvlaaale
Metalloenzyme Metalloenzyme superfamily 325-406 4.6e-08 22.9 Pfam-A 120-200 (252) alignment 
Range on Protein: 325-406
Range on HMM: 120-200/252.0
DAEPSLSDMTEAAIKMLSKNEEGyFLFVESGRIDMAHHATKAMKALEDTEEFAAAVELARKMTDEEDTLIVVTSDHSHTMSI
..| |  ..|......| |..   |..|    .||. |. .. .. .  |.. ....   .  ..||.|...|.||.   ..
kpemsakeitdkllealekgkyd.fvvvnlantDmvGHtgdveakvkaieavDerlkelldavekeddlliitADHgnaeem
Sulfatase Sulfatase 77-409 2.1e-07 20.0 Pfam-A 2-257 (308) alignment 
Range on Protein: 77-409
Range on HMM: 2-257/308.0
NVILFLGDGMSVHtiaATRAFMGDSNKQVFFEKFPYLGLSKTYAVnERTPDSANTATAYLTGVKANYGTIGVNAQVQRgdcvTNSSSHVQSIGQWAQEAG
||.| |.| .. .      .. |  .   . ..  . ||  | ..   .| ....  | |||  ..   ...| .|.      ..  ........ .|||
nvvliladdlgag...dlglyggktattpnldrlaeeglrftnfy.saaplcspsraalltgryphnsgvasntevge....gglpqteatLpellkeaG

KWAGLVTTARVTHASPAGVYAhvserNWEHDGeIISSKCSPDVNTDIARQL------Vewpvgqelrvimgggrsyfrdqsqhdetgvsglrtdgrdlis
   ...    ... |  .||      |.  |  ....    .  ..  ..       .                                          
Yntaaigkwhlgwssrqsvyk.....nrgfdr.flgfptgeaalknpekveyngevlr..........................................

dwreIKKQQGAEGKYVWSLKGL-KETDiSKTDYLLGLFDTSHLP-YHGDRRRTHYEDAEPSLSDMTEaaikmlskneegyflfvesgridmaHHATKAMK
    ......   .... . .. .... .|  .|   .  .| | .  |.  . |.. ...... ..                         .....   
....ppeggysddrlldealefllarn.dkpfflylatlapHappeapdeyaekyatffddgeeaar.........................qlleayln

ALEDTEEF-AAAVELARKMTDEEDTLIVVTSDHSHTMSINGY
..| . .. .  .. ...    ..||.|.|||| . .  ...
sveyvDdligrvlaaLeenglldntlvvftSDhgasleesng
Phosphodiest Type I phosphodiesterase / nucleotide pyrophosphatase 324-419 3.3e-07 19.5 Pfam-A 161-262 (365) alignment 
Range on Protein: 324-419
Range on HMM: 161-262/365.0
EDAEPSLSDMTEAAIKMLSKNEEGYFLFVESGRIDMAHH--ATKAMKALEDTEEFAAAVELARKMTDEE----DTLIVVTSDHSHTMSINGYPYRRQNIL
   || ... .....|.| ..|. ..|.|.   .| ..|     .... .  ..   |..  ..  ||.    .|.|...|||  .  .| .  . ...|
lesepkvdtilsdvakrlleeerpdlllvylselDsvgHkfgpdspevedalrrvDraigeLlealdergllentniilvSDHGmadvlnkkvidlnell

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