Synonym: Dmel\CG3264, Dmel_CG3264, CG3264
Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_AP_pd | Subfamily AP | 61-529 | 3.4e-194 | 636.5 | In-house | 2-471 (472) | alignment | ||
Range on Protein: 61-529
Range on HMM: 2-471/472.0
DPQYWYNIADEEITKRLQLPqPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQGNTGEESSLSFERFPYTGLSRTYCSNAQVPDSACTATAYLCGVKTN
....|.. |.||....|.|. .||.||||.|.|||||| .|||.||||||||..|..|||.||..|.|||.|||.||.|..||||||.||||||||||||
sakfwlkkaqeelkealelq.snskkakNvilflgdGmgvstvtaaRilkgqlkgelgeeasLaleeFpyvglsktyssdkqvpdsaatAtAylcGvktn
IVNIGVSAAVEYNNCTASQdpANRLTSIAEWAQNAGKSTGIVTTTTLTHASPSGAYAKTANRMWECDTDVTSYGVdANSCIDMATQLVTQTPGKNFEVMF
.|||.||||...|.||. .....||.|.|..|||.||.||||..|||||.|.||..|||.||.|..|.... ...| |.|.||.....||...|..
ngtiGvdaaverkdCeasa..gkevdsileaAkkaGkatGlVtttrvthAsPaglyahvanRnwesdeevpaeae.kegckdiaqQLieeevgkeldvil
GGGMGKFLPNSIVDSHGNP-GERSDGVNLLSRWQGLHDGGVLVTNRNQLLKLNVSAVSSVIGLFQSKLMNFHLEADDTYQPTLSELTEVTIKKLSQnKEH
|||. ||||.. ||.... |||.|| ||...|. ... ..|.||..|.....|......|||... .......|.. .|.|.|.||.... ||. .|.
GGGrkkflpktvkdseyekkgerkDgrnLieewekekknakyvenrkelenvdksktdrllGlfadshlkyeidrdekeePsLkemtekAlevLsk.nen
GYFAFIEGGLIDYGNHYTKAGYALDEALEFEKAIQLARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILGINQHDTDINGVQYSVLNYAAGPNQYLDE
|.| |.|||.||...| .|| .||.|.|||..|..||...|| |||||||||||.|...||||| ||..|||....... ....|..|.|| ||...|.|
GffLfVEggrIDhahhenkakkaleetlefdeavelaleltdeedTlivvtaDHshtltiagypkrgssilglakesksadelpyttlsyangpgyelte
N----GQRIPLDDIL-GSDDAITPSYIPKDQGVHSGEDVGIFASGPQSHLFTGVMQQSTIPHLMAYAACIGSGKQ
. |.| |... ...|.......| ....|.||||...||||||||.|||..||||.|.||||||.|....
sdleegerkdlteaeteakdyvsqaavpleeetHggeDvavyasGpqshlltGvveqstiahvmayaaclgeaet
|
|||||||||
0037220 | Alkaline phosphatase-like | 56-531 | 1.9e-147 | 481.9 | In-house | 3-475 (479) | alignment | ||
Range on Protein: 56-531
Range on HMM: 3-475/479.0
PPEEMDPQYWYNIADEEITKRLqLPQPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQGNTGEESSLSFERFPYTGLSRTYCSNAQVPDSACTATAYLC
. ...........| . .. | |...|..||||.|.|.|||| .|||.||||..|| .|..|||. |....||..||..||.....|.|||..|||...
lllllllllllllalallllal.llllnkskaknvilfigDGmgvstvtaariylgqllgglgeegllaldkfplvglvkTysvdslvtDSAaaaTAlat
GVKTNIVNIGVSAAVEYNNCTASQDpaNRLTSIAEWAQNAGKSTGIVTTTTLTHASPSGAYAKTANRMWECDTDVTSYGVDANsCIDMATQLVtqtPGKN
|||||. |||.|.|...||... . |....|.|.|. |||.||.||||..|||.|.. ||..||| ||.|... .|..|. | |.||||| .|..
GvKtnngaigvdadvsrdncddplg..npvetilelakeaGkatGlVtTtrithATPAafyAhvanRnweddialqllgleag.ckdiatqlv...lgsg
FEVMFGGGMGKFLPNSIVDSHGN-----PGERSDGVNLLSRWQGLHDGGVLVTNRNQLLKLNV-SAVSSVIGLFQSKLMNFHLEADDTYQPTLSELTEVT
..|..|||. |||.. .| ... .| |.|| .||. .. ..| .||||..|..|.. |.|. ..|||... ....|. | . .|.|.|.||.
ldvilGGGrkyflpkgtldpeydlelllggkrldgrdlleeakekkkgytyvtnreeldaldlgsnvdkllGlfadshlpyeldrdaseePsLaemtekA
IKKLSQnKEHGYFAFIEGGLIDYGNHYTKAGYALDEALEFEKAIQLARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILGINQHDtDINGVQYSVLNY
.. ||. ...|.| ..||| ||...| ..| .||.|.|.|..|...|..... .|||.||||||.|...| ||..||.||||. .. ...|..|. | |
ldlLsk.ndkGFfLmvEggriDhagHandaaaalgevlafdeaveaalefakdddTlvvvtADHshgglilgyadrgnpilgllpgl.lldglpyttlly
AAGPNQYLDENGQRIPLDDILGSDDAITPSYIPKDQGVHSGEDVGIFASGPQSHLFTGVMQQSTIPHLMAYAACIGSGKQVC
| ||. .| . .. .. . . ....... ..| |.|||| ..|.||...||.||.... |.|..|.|...| . ..
angpgflllldlrldltllvtlallllqralvgwtsggHtgedVpvyayGpgaelflgvyentdiahviasalglgllevll
|
|||||||||
Alk_phosphatase | Alkaline phosphatase | 87-524 | 7.6e-123 | 401.1 | Pfam-A | 1-421 (421) | alignment | ||
Range on Protein: 87-524
Range on HMM: 1-421/421.0
AKNIIMFLGDGMPLSTVAAARILKGQRQGNTGEESsLSFERFPYTGLSRTYCSNAQVPDSACTATAYLCGVKTNIVNIGVSaaveynnctasqDPANRLT
|||.|...|||| |||.|||.||.|..|..||| | ..|.|..|||.||....||.|||.|||||.|||||. |||. . .. .
aknvilligDGmgvstvtaaRslkeqakgklgeei.laldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd............thgkevk
SIAEWAQNAGKSTGIVTTTTLTHASPSGAYAKTANRMWECDTDVtSYGVDANSCIDMATQLVTQTpgKNFEVMFGGGMGKFLPNSIVDSHGNPGERSDGV
|. |.|..||||||.|||| .|||.|.. .|..|.| || |... . . . |.|.||. .. |...|..||| .|||.. |.... | | ||
svleaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaat.aasakkeGkkdiaeqlikak..kkidvllGGGrkeflptgtkdeekerGtrldgr
NLLSRWqgLHDGGVLVTNRNQLLKLNVSA-VSSVIGLFQSKLMNFHLEADDTYQPTLSELTEVTIKKLSQNKeHGYFAFIEGGLIDYGNHYTKAGYALDE
|| .. . | .|..|..||| . . |. ..|||. . ....|| |.. .|.|.|.||| ||.||.|. .|.| ..||. || ..| ..| ||.|
nlieea..kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkvelerdekeePsLkemtevAiklLskne.kGFFLlVEGsrIDhaaHendavgalsE
ALEFEKAIQLARDMT-DIEDTLIVVTADHGHAVSIAGYPGRGTPILGINQHDTDINGVQYSVLNYAAGPNQYLDE-NGQRIPLDDIlGSDDAITPSYIPK
..||..|.. | ... ..||.|||||| |..||.||. ||| | |. . .. .| .. ...|. |. . ... . . . .. ... . | ..
vvefdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaakktkdgkakklilygngegakvedgarenvtaeea.lekiyrkrsavgl
DQGVHSGEDVGIFASGPQSHLFTGVMQQSTIPHLMAYAACI
.. |.|||| .|| ||...|..||..| .|.. .|.|...
tseeHtgedvavfAygpkaelvrGvqeqteiakvlaaalel
|
|||||||||
Alk_phosphatase | Alkaline phosphatase | 87-524 | 7.6e-123 | 401.1 | In-house | 1-421 (421) | alignment | ||
Range on Protein: 87-524
Range on HMM: 1-421/421.0
AKNIIMFLGDGMPLSTVAAARILKGQRQGNTGEESsLSFERFPYTGLSRTYCSNAQVPDSACTATAYLCGVKTNIVNIGVSaaveynnctasqDPANRLT
|||.|...|||| |||.|||.||.|..|..||| | ..|.|..|||.||....||.|||.|||||.|||||. |||. . .. .
aknvilligDGmgvstvtaaRslkeqakgklgeei.laldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd............thgkevk
SIAEWAQNAGKSTGIVTTTTLTHASPSGAYAKTANRMWECDTDVtSYGVDANSCIDMATQLVTQTpgKNFEVMFGGGMGKFLPNSIVDSHGNPGERSDGV
|. |.|..||||||.|||| .|||.|.. .|..|.| || |... . . . |.|.||. .. |...|..||| .|||.. |.... | | ||
svleaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaat.aasakkeGkkdiaeqlikak..kkidvllGGGrkeflptgtkdeekerGtrldgr
NLLSRWqgLHDGGVLVTNRNQLLKLNVSA-VSSVIGLFQSKLMNFHLEADDTYQPTLSELTEVTIKKLSQNKeHGYFAFIEGGLIDYGNHYTKAGYALDE
|| .. . | .|..|..||| . . |. ..|||. . ....|| |.. .|.|.|.||| ||.||.|. .|.| ..||. || ..| ..| ||.|
nlieea..kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkvelerdekeePsLkemtevAiklLskne.kGFFLlVEGsrIDhaaHendavgalsE
ALEFEKAIQLARDMT-DIEDTLIVVTADHGHAVSIAGYPGRGTPILGINQHDTDINGVQYSVLNYAAGPNQYLDE-NGQRIPLDDIlGSDDAITPSYIPK
..||..|.. | ... ..||.|||||| |..||.||. ||| | |. . .. .| .. ...|. |. . ... . . . .. ... . | ..
vvefdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaakktkdgkakklilygngegakvedgarenvtaeea.lekiyrkrsavgl
DQGVHSGEDVGIFASGPQSHLFTGVMQQSTIPHLMAYAACI
.. |.|||| .|| ||...|..||..| .|.. .|.|...
tseeHtgedvavfAygpkaelvrGvqeqteiakvlaaalel
|