Gene CG14297 in Drosophila melanogaster

Synonym: Dmel\CG14297, LMW-PTP, Dmel_CG14297, CG14297

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC2
Superfamily CC2
Family LMWPTP
Subfamily LMWPTP
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP056_AA protein Get Run
DmelP056_AA_1-152 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_LMWPTP_pd Subfamily LMWPTP 4-153 7.4e-58 184.7 In-house 2-150 (152) alignment 
Range on Protein: 4-153
Range on HMM: 2-150/152.0
KKILFVCMGNSCSSPMAEVIMQNLMVKTSLY--WEVDSAGLRTWNTGRRPNKRCLQILREHGLRSDHFCRQFTVNDFLYFDYVVAMDEAVFKELLLWAAD
||.||||.|| |.||.||.....|..|..|.  |.||||.......|..|.||.|.||..|||.|.|..||.| .|| .|||..||||...|||  .|..
kkvlfvClGniCrspiaEavlrklvekkglkedwkvdsaaissyhvGkepdkRalsilkkhglksshrarqitkedfsefdyilamDesnlkelkklake

NRAGKhCQVLLLSSFGKNGlPAFIDSLSPtHKLKNFRSAYYQIKECCKQLIL
... | ..||||....|.| ...|....  .. |.|...|.|||||||... 
kkesk.akvlllgeydkkg.keiiedpyy.gdekdFeavykqikecckaflk
0046251 Phosphotyrosine protein phosphatases I 2-152 1.2e-37 119.7 In-house 4-155 (159) alignment 
Range on Protein: 2-152
Range on HMM: 4-155/159.0
TFKKILFVCMGNSCSSPMAEVIMQNLMVKTSLY---WEVDSAGLRTWNTGRRPNKRCLQILREHGLRSDHFCRQFTVNDFLYFDYVVAMDEAVFKELLLW
..||.||||.||.| |||||.....|. ...|    .||||||......|..|..|....|.|.|.  .|..||.|  ||  ||...|||.. ...|| .
mkkkvlfvCtgNicRSpmAeallrhlledaglsdllievdSaGtsalhvgeppdpravavlkelgidlshrarqlteedfeefdlilamddsnlrdllrl

AADNRAGKHCQVLLLSSFGKNGLPAFIDSLSPThkLKNFRSAYYQIKECCKQLI
| ..  || . .| . .  .     . |    .  |..|. .. .|.|....|.
apgdargkvllllefagllellhwdvpDPyygg..leaFeevldlieeaveall
0053360 Phosphotyrosine protein phosphatases I 2-152 1.8e-35 112.5 In-house 4-153 (157) alignment 
Range on Protein: 2-152
Range on HMM: 4-153/157.0
TFKKILFVCMGNSCSSPMAEVIMQNLMVKTSLY--WEVDSAGLRTWNTGRRPNKRCLQILREHGLRSDHFCRQFTVNDFLYFDYVVAMDEAVFKELLLWA
..||.||||.||.| |||||.....|. ...|   .||||||......|.....|....|.|.|.  .|..||.|  |.  ||....||.. ..||| ..
kmkkvLfvCtgNicRSpmAeallrhlleeaglgdrfevdSaGtsalhvggpvdpravevlaelgidlshrarqlteedleefdliltmddsnleellplf

ADNRAGKHCqVLLLSSFGKNGLPAFIDSLspTHKLKNFRSAYYQIKECCKQLI
 .    |.  |||| .| .     . |     . |..|. .. .|.|....|.
pglleakgk.vllllefagllhwdvpDPy..yggleafelvldlieeaveall
0048765 Phosphotyrosine protein phosphatases I 3-152 6.3e-35 110.7 In-house 2-150 (154) alignment 
Range on Protein: 3-152
Range on HMM: 2-150/154.0
FKKILFVCMGNSCSSPMAEVIMQNLMVKTSLY--WEVDSAGLRTWNTGRRPNKRCLQILREHGLRSDHFCRQFTVNDFLYFDYVVAMDEAVFKELLLWAA
.||.||||.||.| ||||| ....|. ...|   .||||||......|.....|....|.|.|.  .|..||.|  |.  ||....||.. ..||| .. 
mkkvLfvCtgNicRSpmAeallrhlleeaglgdrvevdSaGtsayhvgepvdpravevlaelgidlshrarqlteedleefdliltmddsnleellplfp

DNrAGKHCQVLLLSSFGKNGLPAFIDSLspTHKLKNFRSAYYQIKECCKQLI
.   . . .|||| .| .     . |     . |..|. .. .|.|....|.
gl.leakgkvllllefagllhwdvpDPy..yggleafeevldlieeaveall
0042188 Phosphotyrosine protein phosphatases I 2-152 1.6e-34 109.3 In-house 3-140 (146) alignment 
Range on Protein: 2-152
Range on HMM: 3-140/146.0
TFKKILFVCMGNSCSSPMAEVIMQNLMvktSLYWEVDSAGLRTWNTGRRPNKRCLQILREHGLRSD-HFCRQFTVNDFLYFDYVVAMDEAVFKELLLWAA
..||.||||.||.| |||||.....|.   . ..||||||......|.... |....|.|.|.  . |..||.|  |. .||.|..||.. ...|| .. 
kkkkvlfvCtgNicRSpmAeallrhll...gdrvevdSAGtsayhvgepvdpravevlaelgidisghrarqlteedleefDlvltmddsnlrdllplfp

DNRAGKHCQVLL-LssfgknglpafiDSLSPTHKLKNFRSAYYQIKECCKQLI
..  || . .|               |   |. . . |. .. .|.|..|.|.
gaakgkvllllefw............dvpDPyyggeafeevldlieeavkall
0047618 Phosphotyrosine protein phosphatases I 4-151 8.6e-28 87.3 In-house 2-132 (137) alignment 
Range on Protein: 4-151
Range on HMM: 2-132/137.0
KKILFVCMGNSCSSPMAEVIMQNLMVKTslyWEVDSAGLRTWNtgrrPNKRCLQILREHGLRSD-HFCRQFTVNDFLYFDYVVAMDEAVFKELLLWAADN
||.||||.||.| |||||.....|. .    .||||||.....    .. | ...|.|.|.  . |. .|..  |.  ||.|..||.  ...|.|.| . 
kkvlfvCtgNicRSpmAeallrhllgdr...vevdSAGtepag....vdpravevlaelgidisghrskqldeldlpefdlvltmddsalealpllapaa

RAGKHcqvlllssfgknglpAFID----SLSPTHKLKNFRSAYYQIKECCKQL
.  ..                . |    . ....||. |. .. .|.|....|
lrlhw...............dvpDPyygggteeekleafervldlieerveal
LMWPc_SSU72_ArsC 4-107 1.6e-27 86.9 In-house 1-98 (126) alignment 
Range on Protein: 4-107
Range on HMM: 1-98/126.0
KKILFVCMGNSCSSPMAEVIMQNLMVKtslYWEVDSAGLRTWNTGRRPNKRCLQILREHGLRSDHFCRQFTVNDFLYFDYVVAMDEAVFKELLLWAADNr
||.||||.||.| ||||| ...... |    ..|.|||. ... | ....|. ..|.|.|.. .|  ||.. .|.  ||....|||....|.|  .  . 
kkvlfvClgNicRSpmAeavlkkavkk...glnvsSaGtgaavpgksidsravellkengielkhkprqlqeedlkefdliltmdernkdevlellper.

agKH
  ..
..at
0051181 Phosphotyrosine protein phosphatases I 5-151 9.5e-27 83.8 In-house 1-121 (124) alignment 
Range on Protein: 5-151
Range on HMM: 1-121/124.0
KILFVCMGNSCSSPMAEVIMQNLMVKtslyWEVDSAGLrtwNTGRRPNKRCLQILREHGLRSDHFCRQFTVNDFLYFDYVVAMDEAVFKELLLWAAdnra
|.||||.||.| |||||.....|. .    .||||||.   ..|.....|....|.|.|.  .....|..  |. .||.|..||.  .. || .|     
kvlfvCtgNicRSpmAeallrhllgd....vevdSAGt...hpggpvdpravevlaelgidlslrskqldeldleefdlvltmddsnlcpllplap....

gkhcqvlllssfgK---NglpAFIDSLspTHKLKNFRSAYYQIKECCKQL
             .        . |    .. |. |. .. .|.|....|
.............lllhw...dvpDPy..yggleefeevldlieerveal
LMWPc Low molecular weight phosphotyrosine protein phosphatase 6-151 1.6e-26 83.8 Pfam-A 1-137 (138) alignment 
Range on Protein: 6-151
Range on HMM: 1-137/138.0
ILFVCMGNSCSSPMAEVIMQNLMVKT-SLYWEVDSAGLRTWnTGRRPNKRCLQILREHGLRSD-HFCRQFTVNDFLYFDYVVAMDEAVFKELLLWAADnr
.||||.||.| ||||| ....|. |  .  .||||||.. .  |.....| ...|.|.|.. . |  ||.. ...  ||.....||.  .||   |    
vlfvCtgNicRSpmAeallrallekalgdkvevdSAGteal.vgesvdpravevlkekgidisghrarqlseeelkefDliltldeeaarelcpvape..

aGKHCQVLLLSSfgknglpaFIDSLSPTH-KLKNFRSAYYQIKECCKQL
  |. .| || .          |   |   . ..|.. . .|.|..|.|
.kkeakvvllge........qwdipDPygkeeeefeevrdeieervkkl
LMWPc Low molecular weight phosphotyrosine protein phosphatase 6-151 1.6e-26 83.8 In-house 1-137 (138) alignment 
Range on Protein: 6-151
Range on HMM: 1-137/138.0
ILFVCMGNSCSSPMAEVIMQNLMVKT-SLYWEVDSAGLRTWnTGRRPNKRCLQILREHGLRSD-HFCRQFTVNDFLYFDYVVAMDEAVFKELLLWAADnr
.||||.||.| ||||| ....|. |  .  .||||||.. .  |.....| ...|.|.|.. . |  ||.. ...  ||.....||.  .||   |    
vlfvCtgNicRSpmAeallrallekalgdkvevdSAGteal.vgesvdpravevlkekgidisghrarqlseeelkefDliltldeeaarelcpvape..

aGKHCQVLLLSSfgknglpaFIDSLSPTH-KLKNFRSAYYQIKECCKQL
  |. .| || .          |   |   . ..|.. . .|.|..|.|
.kkeakvvllge........qwdipDPygkeeeefeevrdeieervkkl
0047572 Phosphotyrosine protein phosphatases I 3-151 3.6e-26 81.9 In-house 2-127 (130) alignment 
Range on Protein: 3-151
Range on HMM: 2-127/130.0
FKKILFVCMGNSCSSPMAEVIMQNLMVKTslyWEVDSAGLRtwntGRRPNKRCLQILREHGLRS-DHFCRQFTVNDFLYFDYVVAMDEAVFKELLLWAAd
.||.||||.|||| |||||.....|. .    .||.|||..    |.... |....|.|.|.   .|...|..  ..  ||.|..||.  ...|.|.|  
kkkvlfvCtgNscRSpmAeallrhllgdr...vevySAGte....gsgvdpravevlaelgidisghrskqldelllpefdlvitmddsalealpllap.

NRAGKHCqvlllssfgknglpAFIDSLSPThkLKNFRSAYYQIKECCKQL
. . .|                . |    .  |. || .. .|......|
aalrlhw..............dipDPyggg..leafrevrdlierrvlal
LMWPc_SSU72 4-102 1.2e-21 68.0 In-house 1-95 (137) alignment 
Range on Protein: 4-102
Range on HMM: 1-95/137.0
KKILFVCMGNSCSSPMAEVIMQNLMVktslYWEVDSAGLRTWNTGRRPNKRCLQILREHGLRSDHFCRQFTVNDFLYFDYVVAMDEAVFKELLLWAADN
.|.||||..|.. |..|| .... .      .||.|||....  |....|.  ....|.||. ..  .... ...  ||.|....| ||.... .. ..
lkvlfVCasNinRSmeAeallkeale....glevkSaGtgslvpgpsidkpaeelykenGlsikeapeklqeeelekfDlvitleervfdavvedlper
subfamily_Sponge-LMWPTP-like_pd Subfamily Sponge-LMWPTP-like 5-41 8.2e-08 22.0 In-house 2-38 (173) alignment 
Range on Protein: 5-41
Range on HMM: 2-38/173.0
KILFVCMGNSCSSPMAEVIMQNLMVKTSLYWEVDSAG
|.|||| |||| |||| .. ...  .     | ||| 
kllfvcsgnscrspmamivaekmeaerekiiesdsaa