Gene primo-1 in Drosophila melanogaster

Synonym: CG31311, CG33748, CG9599, Dmel\CG33748, LMW-PTP, primo, Dmel_CG33748, primo-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC2
Superfamily CC2
Family LMWPTP
Subfamily LMWPTP
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP058_AA protein Get Run
DmelP058_AA_0-151 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_LMWPTP_pd Subfamily LMWPTP 3-151 1.8e-67 215.9 In-house 2-151 (152) alignment 
Range on Protein: 3-151
Range on HMM: 2-151/152.0
RKVLMICLGNICRSPIAEVVMVDTLEKANVK-DVEVDSAAIGGWHVGNRADPRAISTLQKHGLKCTHIVRQIRKQDFSEFDYIFGMDEDNMSELRRLAP-
.|||..||||||||||||.|. ...||...| |..||||||  .|||...|.||.|.|.|||||..|..|||.|.||||||||..|||.|..||..||. 
kkvlfvClGniCrspiaEavlrklvekkglkedwkvdsaaissyhvGkepdkRalsilkkhglksshrarqitkedfsefdyilamDesnlkelkklake

-KGSKAELLMLGDFGlEKKNRIIEDPYYeRGAEGFETAYQQCVVACAAFMKE
 |.|||..|.||... .|...||||||| .... ||..|.|.. .|.||.|.
kkeskakvlllgeyd.kkgkeiiedpyy.gdekdFeavykqikecckaflkk
0046251 Phosphotyrosine protein phosphatases I 2-150 7.3e-46 146.4 In-house 5-156 (159) alignment 
Range on Protein: 2-150
Range on HMM: 5-156/159.0
VRKVLMICLGNICRSPIAEVVMVDTLEKANVKD--VEVDSAAIGGWHVGNRADPRAISTLQKHGLKCTHIVRQIRKQDFSEFDYIFGMDEDNMSELRRLA
. |||..|.|||||||.||... . ||.|...|  .|||||.....|||...||||...|...|....|. ||....|| |||.|..||..|...|.|||
kkkvlfvCtgNicRSpmAeallrhlledaglsdllievdSaGtsalhvgeppdpravavlkelgidlshrarqlteedfeefdlilamddsnlrdllrla

PKGSKAELLMLGDFGLEKK--NRIIEDPYYeRGAEGFETAYQQCVVACAAFMK
|.......|.|..|  . .  .  ..||||  | |.||....... |. |...
pgdargkvllllefagllellhwdvpDPyy.ggleaFeevldlieeavealle
0053360 Phosphotyrosine protein phosphatases I 2-150 1.4e-43 138.8 In-house 5-154 (157) alignment 
Range on Protein: 2-150
Range on HMM: 5-154/157.0
VRKVLMICLGNICRSPIAEVVMVDTLEKANVKD-VEVDSAAIGGWHVGNRADPRAISTLQKHGLKCTHIVRQIRKQDFSEFDYIFGMDEDNMSELRRLAP
. |||..|.|||||||.||... . ||.|...| .||||| ....|||...||||...|...|....|. ||....|. |||.|. ||..|..||..|.|
mkkvLfvCtgNicRSpmAeallrhlleeaglgdrfevdSaGtsalhvggpvdpravevlaelgidlshrarqlteedleefdliltmddsnleellplfp

K--GSKAELLMLGDFGlEKKNRIIEDPYyERGAEGFETAYQQCVVACAAFMK
.  ..|...|.|..|  .  .. ..|||  .|.|.||....... |. |...
glleakgkvllllefa.gllhwdvpDPy.yggleafelvldlieeavealle
0048765 Phosphotyrosine protein phosphatases I 1-150 1.7e-43 138.5 In-house 1-151 (154) alignment 
Range on Protein: 1-150
Range on HMM: 1-151/154.0
MVRKVLMICLGNICRSPIAEVVMVDTLEKANVKD-VEVDSAAIGGWHVGNRADPRAISTLQKHGLKCTHIVRQIRKQDFSEFDYIFGMDEDNMSELRRLA
|. |||..|.|||||||.|| .. . ||.|...| |||||| ....|||...||||...|...|....|. ||....|. |||.|. ||..|..||..|.
mmkkvLfvCtgNicRSpmAeallrhlleeaglgdrvevdSaGtsayhvgepvdpravevlaelgidlshrarqlteedleefdliltmddsnleellplf

PK--GSKAELLMLGDFGlEKKNRIIEDPYyERGAEGFETAYQQCVVACAAFMK
|.  ..|...|.|..|  .  .. ..|||  .| |.||....... |. |...
pglleakgkvllllefa.gllhwdvpDPy.yggleafeevldlieeavealle
0042188 Phosphotyrosine protein phosphatases I 2-151 6.6e-40 126.7 In-house 4-142 (146) alignment 
Range on Protein: 2-151
Range on HMM: 4-142/146.0
VRKVLMICLGNICRSPIAEVVMVDTLEKAnvkdVEVDSAAIGGWHVGNRADPRAISTLQKHGLKCT-HIVRQIRKQDFSEFDYIFGMDEDNMSELRRLAP
. |||..|.|||||||.||... . |..     |||||| ....|||...||||...|...|.. . |. ||....|. |||... ||..|...|..|.|
kkkvlfvCtgNicRSpmAeallrhllgdr....vevdSAGtsayhvgepvdpravevlaelgidisghrarqlteedleefDlvltmddsnlrdllplfp

KGSKAELLMLGDFGlekknrIIEDPYYERgaEGFETAYQQCVVACAAFMKE
. .|. .|.|..|        ..||||    |.||......  |. |....
gaakgkvllllefw......dvpDPyygg..eafeevldlieeavkallel
LMWPc Low molecular weight phosphotyrosine protein phosphatase 5-149 7.5e-39 123.8 Pfam-A 1-138 (138) alignment 
Range on Protein: 5-149
Range on HMM: 1-138/138.0
VLMICLGNICRSPIAEVVMVDTLEKANVKDVEVDSAAIGGWhVGNRADPRAISTLQKHGLKCT-HIVRQIRKQDFSEFDYIFGMDEDNMSELRRLAPKGS
||..|.|||||||.|| .. . ||||  ..||||||..... ||...||||...|...|.. . |. ||.......|||.|. .||.. .||...||. .
vlfvCtgNicRSpmAeallrallekalgdkvevdSAGteal.vgesvdpravevlkekgidisghrarqlseeelkefDliltldeeaarelcpvapekk

KAELLMLGDfglekkNRIIEDPYYERgAEGFETAYQQCVVACAAFM
.|   .||.      .. |.|||..  .| ||. ....  ......
eakvvllge......qwdipDPygke.eeefeevrdeieervkkll
LMWPc Low molecular weight phosphotyrosine protein phosphatase 5-149 7.5e-39 123.8 In-house 1-138 (138) alignment 
Range on Protein: 5-149
Range on HMM: 1-138/138.0
VLMICLGNICRSPIAEVVMVDTLEKANVKDVEVDSAAIGGWhVGNRADPRAISTLQKHGLKCT-HIVRQIRKQDFSEFDYIFGMDEDNMSELRRLAPKGS
||..|.|||||||.|| .. . ||||  ..||||||..... ||...||||...|...|.. . |. ||.......|||.|. .||.. .||...||. .
vlfvCtgNicRSpmAeallrallekalgdkvevdSAGteal.vgesvdpravevlkekgidisghrarqlseeelkefDliltldeeaarelcpvapekk

KAELLMLGDfglekkNRIIEDPYYERgAEGFETAYQQCVVACAAFM
.|   .||.      .. |.|||..  .| ||. ....  ......
eakvvllge......qwdipDPygke.eeefeevrdeieervkkll
LMWPc_SSU72_ArsC 4-141 4.3e-37 117.8 In-house 2-126 (126) alignment 
Range on Protein: 4-141
Range on HMM: 2-126/126.0
KVLMICLGNICRSPIAEVVMVDTLEKanvkDVEVDSAAIGGWHVGNRADPRAISTLQKHGLKCTHIVRQIRKQDFSEFDYIFGMDEDNMSELRRLAPKGS
|||..|||||||||.|| |. . ..|    ...|.||..| ...|...|.||...|...|.. .|  ||....|..|||.|..|||.|..|...|.|.  
kvlfvClgNicRSpmAeavlkkavkk....glnvsSaGtgaavpgksidsravellkengielkhkprqlqeedlkefdliltmdernkdevlellpera

KAELLMLgdfglekkNRIIEDPYYERgAEGFETAYQQC
.... .|        |. ..|||..  ..||| .....
tkkvhll........nldvkDpyega.esgfeevldli
0051181 Phosphotyrosine protein phosphatases I 4-149 5.2e-32 100.7 In-house 1-122 (124) alignment 
Range on Protein: 4-149
Range on HMM: 1-122/124.0
KVLMICLGNICRSPIAEVVMVDTLEKanvkdVEVDSAAIggwHVGNRADPRAISTLQKHGLKCTHIVRQIRKQDFSEFDYIFGMDEDNMSELRRLAPkgs
|||..|.|||||||.||... . |..     |||||| .   |.|...||||. .|...|...... .|....|. |||... ||..|.  |..|||   
kvlfvCtgNicRSpmAeallrhllgd.....vevdSAGt...hpggpvdpravevlaelgidlslrskqldeldleefdlvltmddsnlcpllplap...

kaellmlgdfglEKKNRIIEDPYyERGAEGFETAYQQCVVACAAFM
            .  .  ..||| . | |.||......  .. |..
............lllhwdvpDPy.yggleefeevldlieerveall
0047618 Phosphotyrosine protein phosphatases I 4-150 6.4e-31 97.4 In-house 3-134 (137) alignment 
Range on Protein: 4-150
Range on HMM: 3-134/137.0
KVLMICLGNICRSPIAEVVMVDTLEKAnvkdVEVDSAAIGGWHvgnrADPRAISTLQKHGLKCT-HIVRQIRKQDFSEFDYIFGMDEDNMSELRRLAPKG
|||..|.|||||||.||... . |..     |||||| .....    .||||. .|...|.. . |. .|....|. |||... ||......|..|||. 
kvlfvCtgNicRSpmAeallrhllgdr....vevdSAGtepag....vdpravevlaelgidisghrskqldeldlpefdlvltmddsalealpllapaa

SKAELlmlgdfglekknrIIEDPYYERG-----AEGFETAYQQCVVACAAFMK
  . .              ..||||  |     .|.||......  .. |...
lrlhw.............dvpDPyygggteeekleafervldlieervealle
LMWPc_SSU72 4-151 4.9e-29 92.0 In-house 2-137 (137) alignment 
Range on Protein: 4-151
Range on HMM: 2-137/137.0
KVLMICLGNICRSPIAEVVMVDTLEkanvkDVEVDSAAIGGWHVGNRADPRAISTLQKHGLKCTHIVRQIRKQDFSEFDYIFGMDEDNMSELRRLAPKG-
|||..|..||.||..|| .. . ||      .||.|| .| ...|...|..| ......||. ..  ..........||... ..|... .. . .|.  
kvlfVCasNinRSmeAeallkeale.....glevkSaGtgslvpgpsidkpaeelykenGlsikeapeklqeeelekfDlvitleervfdavvedlpers

-SKAELLMLgdfglekkNRIIEDPYYERgAEGFETAYQQCVVACAAFMKE
 .|.. ...        |  |.||..|   |||.......  .. ....|
elkrkvhvi........nvdikDpheea.iegfkaildlieervkellae
0047572 Phosphotyrosine protein phosphatases I 2-149 2.4e-27 85.7 In-house 2-128 (130) alignment 
Range on Protein: 2-149
Range on HMM: 2-128/130.0
VRKVLMICLGNICRSPIAEVVMVDTLekanVKDVEVDSAAIGgwhvGNRADPRAISTLQKHGLKC-THIVRQIRKQDFSEFDYIFGMDEDNMSELRRLAP
. |||..|.||.||||.||... . |     ..|||.|| ..    |...||||. .|...|..  .|. .|. .... |||... ||......|..|||
kkkvlfvCtgNscRSpmAeallrhll....gdrvevySAGte....gsgvdpravevlaelgidisghrskqldelllpefdlvitmddsalealpllap

KGSKAELlmlgdfglekknrIIEDPYYERgAEGFETAYQQCVVACAAFM
.   . .              |.|||.    |.|.......  .. |..
aalrlhw.............dipDPyggg.leafrevrdlierrvlall
subfamily_Sponge-LMWPTP-like_pd Subfamily Sponge-LMWPTP-like 4-41 1.5e-07 21.1 In-house 2-38 (173) alignment 
Range on Protein: 4-41
Range on HMM: 2-38/173.0
KVLMICLGNICRSPIAEVVmVDTLEKANVKDVEVDSAA
|.|..| || ||||.| .|  . .|    | .| ||||
kllfvcsgnscrspmamiv.aekmeaerekiiesdsaa