Gene primo-2 in Drosophila melanogaster

Synonym: CG31311, CG33747, CG9599, Dmel\CG33747, LMW-PTP, primo, Dmel_CG33747, primo-2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC2
Superfamily CC2
Family LMWPTP
Subfamily LMWPTP
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP059_AA protein Get Run
DmelP059_AA_5-156 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_LMWPTP_pd Subfamily LMWPTP 8-157 1.3e-64 206.6 In-house 2-151 (152) alignment 
Range on Protein: 8-157
Range on HMM: 2-151/152.0
SSVLMVCVGNLCRSPIAEAVMRDLVARAGLQGEWHVESAGIEDWHSGHQPDERALNVLARHNIEYNGKARVLAPEDFLEFDYIFAMDLSNLAALRRMAP-
..||.||.||.|||||||||.|.||...||. .|.|.||.|...| |..||.|||..| .|..... .||... ||| |||||.||| |||. |...|. 
kkvlfvClGniCrspiaEavlrklvekkglkedwkvdsaaissyhvGkepdkRalsilkkhglksshrarqitkedfsefdyilamDesnlkelkklake

-KGTTAKLLILGNFGlKPDERIIEDPYYdIGEASFEEIYRQCSIACRNFLKQ
 |...||.|.||... | ...|||||||  .|..||..|.|.. .|..|||.
kkeskakvlllgeyd.kkgkeiiedpyy.gdekdFeavykqikecckaflkk
0046251 Phosphotyrosine protein phosphatases I 7-156 2.1e-45 144.8 In-house 5-156 (159) alignment 
Range on Protein: 7-156
Range on HMM: 5-156/159.0
KSSVLMVCVGNLCRSPIAEAVMRDLVARAGLQGE-WHVESAGIEDWHSGHQPDERALNVLARHNIEYNGKARVLAPEDFLEFDYIFAMDLSNLAALRRMA
| .||.||.|| ||||.|||..|.|...|||..  ..| |||....| |..||.||. ||....|... .|| | .||| |||.|.||| |||..|.|.|
kkkvlfvCtgNicRSpmAeallrhlledaglsdllievdSaGtsalhvgeppdpravavlkelgidlshrarqlteedfeefdlilamddsnlrdllrla

PKGTTAKLLILGNFGLKPD--ERIIEDPYYdIGEASFEEIYRQCSIACRNFLK
|.....|.|.|..|    .     ..||||  | . |||.....  |....|.
pgdargkvllllefagllellhwdvpDPyy.ggleaFeevldlieeavealle
0053360 Phosphotyrosine protein phosphatases I 6-156 5.7e-44 140.1 In-house 4-154 (157) alignment 
Range on Protein: 6-156
Range on HMM: 4-154/157.0
QKSSVLMVCVGNLCRSPIAEAVMRDLVARAGLQGEWHVESAGIEDWHSGHQPDERALNVLARHNIEYNGKARVLAPEDFLEFDYIFAMDLSNLAALRRMA
.. .||.||.|| ||||.|||..|.|...|||.....| |||....| |...|.||. |||...|... .|| | .||. |||.|..|| |||..|....
kmkkvLfvCtgNicRSpmAeallrhlleeaglgdrfevdSaGtsalhvggpvdpravevlaelgidlshrarqlteedleefdliltmddsnleellplf

PK--GTTAKLLILGNFGlKPDERIIEDPYyDIGEASFEEIYRQCSIACRNFLK
|.  ....|.|.|..|  .   . ..|||   |.. ||......  |....|.
pglleakgkvllllefa.gllhwdvpDPy.yggleafelvldlieeavealle
0048765 Phosphotyrosine protein phosphatases I 8-156 1.1e-43 139.0 In-house 3-151 (154) alignment 
Range on Protein: 8-156
Range on HMM: 3-151/154.0
SSVLMVCVGNLCRSPIAEAVMRDLVARAGLQGEWHVESAGIEDWHSGHQPDERALNVLARHNIEYNGKARVLAPEDFLEFDYIFAMDLSNLAALRRMAPK
 .||.||.|| ||||.|||..|.|...|||.....| |||....| |...|.||. |||...|... .|| | .||. |||.|..|| |||..|....|.
kkvLfvCtgNicRSpmAeallrhlleeaglgdrvevdSaGtsayhvgepvdpravevlaelgidlshrarqlteedleefdliltmddsnleellplfpg

--GTTAKLLILGNFGlKPDERIIEDPYyDIGEASFEEIYRQCSIACRNFLK
  ....|.|.|..|  .   . ..|||   |.. |||.....  |....|.
lleakgkvllllefa.gllhwdvpDPy.yggleafeevldlieeavealle
0042188 Phosphotyrosine protein phosphatases I 6-156 3.2e-39 124.5 In-house 3-141 (146) alignment 
Range on Protein: 6-156
Range on HMM: 3-141/146.0
QKSSVLMVCVGNLCRSPIAEAVMRDLVaraglQGEWHVESAGIEDWHSGHQPDERALNVLARHNIEYNG-KARVLAPEDFLEFDYIFAMDLSNLAALRRM
.| .||.||.|| ||||.|||..|.|.     .. ..| |||....| |...|.||. |||...|...|  || | .||. |||....|| |||. |...
kkkkvlfvCtgNicRSpmAeallrhll.....gdrvevdSAGtsayhvgepvdpravevlaelgidisghrarqlteedleefDlvltmddsnlrdllpl

APKGTTAKLLILGNFGlkpderIIEDPYYDIgeASFEEIYRQCSIACRNFLK
.|. ...|.|.|..|        ..||||      |||.....  |....|.
fpgaakgkvllllefw......dvpDPyygg..eafeevldlieeavkalle
LMWPc Low molecular weight phosphotyrosine protein phosphatase 10-155 6.3e-38 120.8 Pfam-A 1-138 (138) alignment 
Range on Protein: 10-155
Range on HMM: 1-138/138.0
VLMVCVGNLCRSPIAEAVMRDLVARAgLQGEWHVESAGIEDWhSGHQPDERALNVLARHNIEYNGK-ARVLAPEDFLEFDYIFAMDLSNLAALRRMAPKG
||.||.|| ||||.|||..|.|. .| |. .. |.|||.| .  |...|.||..||... |. .|. || |  |.. |||.|...| .... |...||. 
vlfvCtgNicRSpmAeallralleka.lgdkvevdSAGteal.vgesvdpravevlkekgidisghrarqlseeelkefDliltldeeaarelcpvapek

TTAKLLILGNfglkpdERIIEDPYYDIgEASFEEIYRQCSIACRNFL
..||  .||.      .. |.|||..  |. |||.. ... .....|
keakvvllge......qwdipDPygke.eeefeevrdeieervkkll
LMWPc Low molecular weight phosphotyrosine protein phosphatase 10-155 6.3e-38 120.8 In-house 1-138 (138) alignment 
Range on Protein: 10-155
Range on HMM: 1-138/138.0
VLMVCVGNLCRSPIAEAVMRDLVARAgLQGEWHVESAGIEDWhSGHQPDERALNVLARHNIEYNGK-ARVLAPEDFLEFDYIFAMDLSNLAALRRMAPKG
||.||.|| ||||.|||..|.|. .| |. .. |.|||.| .  |...|.||..||... |. .|. || |  |.. |||.|...| .... |...||. 
vlfvCtgNicRSpmAeallralleka.lgdkvevdSAGteal.vgesvdpravevlkekgidisghrarqlseeelkefDliltldeeaarelcpvapek

TTAKLLILGNfglkpdERIIEDPYYDIgEASFEEIYRQCSIACRNFL
..||  .||.      .. |.|||..  |. |||.. ... .....|
keakvvllge......qwdipDPygke.eeefeevrdeieervkkll
LMWPc_SSU72_ArsC 9-147 1.9e-37 119.0 In-house 2-126 (126) alignment 
Range on Protein: 9-147
Range on HMM: 2-126/126.0
SVLMVCVGNLCRSPIAEAVMRDLVARaglqgEWHVESAGIEDWHSGHQPDERALNVLARHNIEYNGKARVLAPEDFLEFDYIFAMDLSNLAALRRMAPKG
.||.||.|| ||||.||||....|..     ...|.|||..... |...|.|| ..|....||.. |.| |  ||. |||.|..|| .| .......|. 
kvlfvClgNicRSpmAeavlkkavkk.....glnvsSaGtgaavpgksidsravellkengielkhkprqlqeedlkefdliltmdernkdevlellper

TTAKLLILgnfglkpdERIIEDPYYDIgEASFEEIYRQC
.|.|. .|        .. ..|||.   | .|||.....
atkkvhll........nldvkDpyega.esgfeevldli
0047618 Phosphotyrosine protein phosphatases I 9-156 5.2e-32 100.9 In-house 3-134 (137) alignment 
Range on Protein: 9-156
Range on HMM: 3-134/137.0
SVLMVCVGNLCRSPIAEAVMRDLvaragLQGEWHVESAGIEDWHsghqPDERALNVLARHNIEYNG-KARVLAPEDFLEFDYIFAMDLSNLAALRRMAPK
.||.||.|| ||||.|||..|.|     |.....| |||.|...    .|.||. |||...|...| ... | ..|. |||....|| |.|.||...||.
kvlfvCtgNicRSpmAeallrhl.....lgdrvevdSAGtepag....vdpravevlaelgidisghrskqldeldlpefdlvltmddsalealpllapa

GTTAKLlilgnfglkpderIIEDPYYDIG-----EASFEEIYRQCSIACRNFLK
 .....              ..||||  |     .. ||......  .....|.
alrlhw.............dvpDPyygggteeekleafervldlieervealle
0051181 Phosphotyrosine protein phosphatases I 9-156 3.3e-31 98.2 In-house 1-123 (124) alignment 
Range on Protein: 9-156
Range on HMM: 1-123/124.0
SVLMVCVGNLCRSPIAEAVMRDLVARaglqgeWHVESAGIedwHSGHQPDERALNVLARHNIEYNGKARVLAPEDFLEFDYIFAMDLSNLAALRRMAPkg
.||.||.|| ||||.|||..|.|...      ..| |||.   | |...|.||. |||...|... ... | ..|. |||....|| ||| .|...||  
kvlfvCtgNicRSpmAeallrhllgd......vevdSAGt...hpggpvdpravevlaelgidlslrskqldeldleefdlvltmddsnlcpllplap..

ttakllilgN---FglkpderIIEDPYyDIGEASFEEIYRQCSIACRNFLK
             .        ..|||   |.. |||.....  .....|.
.........lllhw.......dvpDPy.yggleefeevldlieervealle
0047572 Phosphotyrosine protein phosphatases I 7-156 4.8e-29 91.2 In-house 2-129 (130) alignment 
Range on Protein: 7-156
Range on HMM: 2-129/130.0
KSSVLMVCVGNLCRSPIAEAVMRDLVaraglQGEWHVESAGIEdwhsGHQPDERALNVLARHNIEY-NGKARVLAPEDFLEFDYIFAMDLSNLAALRRMA
| .||.||.|| ||||.|||..|.|.     .....| |||.|    |...|.||. |||...|.. . ... | .... |||....|| |.| ||...|
kkkvlfvCtgNscRSpmAeallrhll.....gdrvevySAGte....gsgvdpravevlaelgidisghrskqldelllpefdlvitmddsalealplla

PKGTTAKLlilgnfglkpderIIEDPYyDIGEASFEEIYRQCSIACRNFLK
|. ... .              |.|||  .| . |.|.....  .....|.
paalrlhw.............dipDPy.gggleafrevrdlierrvlalle
LMWPc_SSU72 9-156 3.8e-26 82.6 In-house 2-136 (137) alignment 
Range on Protein: 9-156
Range on HMM: 2-136/137.0
SVLMVCVGNLCRSPIAEAVMRDLVAraglqgEWHVESAGIEDWHSGHQPDERALNVLARHNIEYNGKARVLAPEDFLEFDYIFAMDLSNLAALRRMAPKG
.||.||..| .||..|||.... ..      .. |.|||..... |...|..| ...... .. . ... |  |.. .||...... ... |. ...|. 
kvlfVCasNinRSmeAeallkeale......glevkSaGtgslvpgpsidkpaeelykenGlsikeapeklqeeelekfDlvitleervfdavvedlper

--TTAKLLILgnfglkpdERIIEDPYYDIgEASFEEIYRQCSIACRNFLK
  ...| ...        .  |.||...   . |..|..... .....|.
selkrkvhvi........nvdikDpheea.iegfkaildlieervkella