Gene Pp1-13C in Drosophila melanogaster

Synonym: CG15305, CG2096, DmPp1-9C, Dmel\CG2096, FLW, FLW/PP1B, PP-1, PP1, PP1 9C, PP1 b9C, PP1 beta9c, PP19C, PP1B_DROME, PP1beta, PP1beta-9C, PP1beta9C, PP1c, Pp1beta-9C, Pp1beta9C, XE55, anon-WO03040301.120, l(1)G0172, Dmel_CG2096, flw

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP087_AA protein Get Run
DmelP087_AA_7-299 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP1C_pd Subfamily PPP1C 21-299 5.3e-162 530.7 In-house 3-281 (282) alignment 
Range on Protein: 21-299
Range on HMM: 3-281/282.0
RPGKNVQLSEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLR
..||.|.|.| ||. |. |.|||||.||||||||||.||.|||||||.|||||||..|.|||.|||||||||||||||||||.|||||||||.||.||||
kkgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllr

GNHECASINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTIGWGENDRG
||||.|||||||||||||||||.|||||||||.|||||. |.|||||.|.||||||.|.|.||||.|.||..||..|||||||||||||.. ||.|||||
GnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrG

VSFTFGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILKPVEK
||||||..|| |||||.|||||.||||||||||||||||||||.|||||||||||||||..|||..|..|||||||..|
vsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpakk
subfamily_PPZ_pd Subfamily PPZ 7-298 4.2e-136 446.3 In-house 3-295 (300) alignment 
Range on Protein: 7-298
Range on HMM: 3-295/300.0
LESIISRLLEVR-GARPGKNVQLSEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLL
.. || .||.    |.  ||| | . ||  .| |.||..|||| ||||  ..|| ||.|||| ||||||   |.|| |||||||||||||||||||| ||
ideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletilll

LAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWS
|.||||| ||||||||||||| . |.||||||||||  ||.|||| | || ||. |||  |||| |||||| | ||..||...||||||| ||. |||||
lcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllws

DPDKDTIGWGENDRGVSFTFGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILKPVE
||   .  | .|.||||. .    . |||.|  .||.|||| |||||||||  | |||.|||||||||||| ||.||| . |.|||..| |..
dptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldpld
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 8-299 5.3e-135 442.2 In-house 4-296 (298) alignment 
Range on Protein: 8-299
Range on HMM: 4-296/298.0
ESIISRLLEVRGARPGKNVQLSEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLA
.......|.|  .      ...| ..  |. ....|. .|. |.|..||.|.|||||||| ||||||. .|.||.|||||||||||||.|.||.|.||||
dellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivllla

YKIKYSENFFLLRGNHECASINRIYGFYDECKRRY-TIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSD
||.|| .|||||||||||..|||.||||.||||||  ..|...| | || ||..|.. ..|.| |||||. |.|..|.|.. ||.| ... |  ||||.|
ykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwad

PDKDTIGWGENDRGVSFTFGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILKPVEK
|.. . || || ||||..||..|| ..|.| |.||..|||||| |||||||...|||.||||.|||.|||. |.|.||. |..||..||| .|
penavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekk
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 6-301 1e-124 408.6 In-house 2-298 (299) alignment 
Range on Protein: 6-301
Range on HMM: 2-298/299.0
NLESIISRLLEVRGARPGKNVQLSEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLL
... ..|.||.|  .       . | |.. ||  ...... |. |||.|||...|||||||| ||||.|.  |.||..|.||||||||||.| ||.|.||
dvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitll

LAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRYT-IKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLW
|..|||| |.||.||||||| .|||.||||.||..||.  .||  | |.|. .|.. ..  .|.| |||||| |....|.| . || | |.  |  ||||
lcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllw

SDPDKDTIGWGENDRGVSFTFGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILKPVEKRK
.|||.  ..|  | ||||. || .|| . ... |.||..||||||.|||||||...|||.|||| |||.|||. |.| ||. |.|.|..||| .|. 
adpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpksl
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 30-297 7.6e-120 392.2 In-house 8-275 (280) alignment 
Range on Protein: 30-297
Range on HMM: 8-275/280.0
EGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASIN
| .| ..  | ..||.||  ..|..||...|||.|||| ||||||.  ..||. ||||||||||||.| || |.||||||..| .||..||||||..|||
eadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisin

RIYGFYDECKRRYTIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTIGWGENDRGVSFTFGAEV
| |||.||.||||. .|.. | . .. ||.||.|  .|.| |||||..| |........|| | .|. |  ||||.||.... ||.|| ||||  |||.|
rkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganv

VVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILKPV
| .. .| |.|||.| ||||.|||||||...|||.||||.|.|||||. |.. ||. |. ||..||| 
vkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
0045823 Metallo-dependent phosphatases 21-299 5.4e-117 384.2 In-house 36-326 (473) alignment 
Range on Protein: 21-299
Range on HMM: 36-326/473.0
RPGKNVQLSEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLR
.  |. .|.| ... |. . .|||  .| ||||.... ..||||||..|||||.|  |.||| ...||||.|||| .|||...||||.|||| .|.||||
hlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllr

GNHECASINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPdKDTIG-------
||||.. .| .|||.||. ..|...|.. | .....||..|....||...||||||||....|||.| || ..|| |||.|||||||  .. |       
GNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddgdgllrlr

-WGENDRGVSFTFGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQ------LVTLFSAPNYCGEFDNAGAMMSVDNTLmCSFQILKPVEK
 .| . ||....||...| .||.|..||||.|.|..|..|||.. ...      ..|.||||||||...| .|.. .|..| .||....|.. 
ffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsph
PP2Ac_SM00156 30-297 1.7e-114 374.4 In-house 3-270 (271) alignment 
Range on Protein: 30-297
Range on HMM: 3-270/271.0
EGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASIN
. |.. |. ...||| ... |.|..||. ..||||||..|||||.| .|.||| .|.|||||||||.||.|.|.||.|.||.|.|...|||||||. |.|
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn

RIYGFYDECKRRYTIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTIGWGENDRGVSFTFGAEV
.||||..|.||.|. .... |...|..||. |.||.||.| ||||||.|.|...||.. |. . |..|||.|||||||.... |.  . ||.|..||...
kiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFgeda

VVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILKPV
| .||.|..|.||.|||.||..||||||...|||.|||||||.||.|..|...|...|..|.. ||. 
vkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
0049330 Metallo-dependent phosphatases 8-299 2.1e-114 374.7 In-house 10-301 (309) alignment 
Range on Protein: 8-299
Range on HMM: 10-301/309.0
ESIISRLLEVRGARPGKNVQLSEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLA
 ..| .||..   .. | ..||| |.. |.|| .|||. .|.||||.... ..||||||..|||||.|  |.||| ...||||.|||| .|||...||||
lelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevllllla

YKIKYSENFFLLRGNHECASINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDP
.|..| .|.||||||||.. .|..|||.||..|.| ..||. |.|....||..|....||.|.||||||||....|||...||...|. |||||||||||
lkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdp

DKDTIGWGENDRGVSFTFGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILKPVEK
. .. |...|.||....||. .| .||.|..||||.|.|..|..||..|....|.|.||||||||...|.||.. .|..|..||....||. 
lpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpl
PPP_1 30-283 4.2e-112 366.7 In-house 3-264 (264) alignment 
Range on Protein: 30-283
Range on HMM: 3-264/264.0
EGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASIN
| |.. |. |..|.|  ...|||.......|||||||..|||.||..|| .|| |||||||||||||.|.|...||||.|.|| ...||||||||.....
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

RIYGFYDECK-RRYTIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLL-------WSDPDKDTIGWGENDRGV
..|||..|.. ..|. ...||.||.|..||. |..||||...||||||.|....|||...| |.||..| |||||       .||..... .. ...||.
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

SFTFGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSV
...||..|. |||||..|.||.|||.|.|.||||..||..||.|||.||. |..|.||....
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
PPP_3 28-295 9.8e-112 365.4 In-house 2-270 (271) alignment 
Range on Protein: 28-295
Range on HMM: 2-270/271.0
LSEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECAS
||| |.. |. | .|||  ...|.|..||...|||||||..|||.||..|| .|| .||||||||||||.|||...||||.||||.....|||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INRIYGFYDECK-RRYTIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTIGWGENDRGVSFTFG
||..|||..|.. .... |..|.....|..||. |..|||....||||||...|..||... |...||..|.|.|||.|...... |.....||....||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

AEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILK
..|. .||.|..|.||.|||...|.|||.......||.|||||||....||||.......|...|..|.
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 28-296 2e-110 361.7 In-house 8-282 (284) alignment 
Range on Protein: 28-296
Range on HMM: 8-282/284.0
LSEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYP------PEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRG
|.| |.  ||...||..  ... ||.|||.||.||||||. ||| |..  |.|       | .|||||||||||  |.| | ||.|||... .. |||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHECASINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTIGWGENDRGV
|||   .|. |||| |||.||. .|...|  .||..|..|.|..||.| |||.| || ...|. .. ||.|.|| |...|| |.||...  |. | .|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SFTFGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILKP
  .|||. | .||.|..|||. |||||| ||||||| |.|||.|||| |||..||..|...||. |..||..|||
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 36-297 1.6e-105 345.6 In-house 31-295 (297) alignment 
Range on Protein: 36-297
Range on HMM: 31-295/297.0
LCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFY
|   . ... ||  ..|..||.|.|||||||. ||||||  ||.|| |||||||||||||. |.||| ||||||.|.  |.|||||||||  .|..||||
lldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkvygfy

DECKRRY-TIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLT---SMEQIRRIMRPTDVpDQGLLCDLLWSDPDKDTIGWGENDRGVSFTFGAEVVV
.||..|| ..... .| | || ||.. .. .||.| |||||| ||   ... .|.| |.|.   ..|..||||.||     |. ||.||    || . |.
eecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqrgagcgfgrdavl

KFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILKPV
|   . .|||.|||||||.||||||| |.|||.|||| |||.|||. |.||.|. | |||.||.| 
klcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
0053225 Metallo-dependent phosphatases 10-297 1.7e-105 345.5 In-house 4-291 (293) alignment 
Range on Protein: 10-297
Range on HMM: 4-291/293.0
IISRLLEVRGARPGKNVQLSEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYK
.| .||..   .  ....||| |.. |.|. .|||. .|.||||.... ..|||||...|||.|.|. |.||| ...||||.|||| .|||...||||.|
lilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalk

IKYSENFFLLRGNHECASINRIYGFYDECKRRY-TIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPD
..| .|..|||||||.. .| .|||.||..|.|   .||. ..|....||..|....||...||||||||....|||.|.||...|. |||.||||||||
llypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd

kDTIGWGENDRGVSFTFGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILKPV
 .  ||. . ||....||. .| .||.|..||||.|.|||| |||... ...|||.||||||.|...|.||.. .|. |...|....||
.lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 32-299 3.1e-105 344.6 In-house 7-276 (284) alignment 
Range on Protein: 32-299
Range on HMM: 7-276/284.0
EIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRI
..  | ... .|.  ||.|.| ..|..||||||||. ||||||.  |.|  ||||||||||||||. |||| ||.|||. . . ||.|||||||. ||.|
dvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinki

YGFYDECKRRYTI-KLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQG-LLCDLLWSDPDKDTIGWGENDRGVSFTFGAEV
||||.||.|||    ....|   |  .|. |.| ..|.| |||.|  |  . |.| | || | |.   |  |.||||| .   ||  | ||||. ||.. 
ygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsda

VVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILKPVEK
. |.|.. ..||. ||||||.|||||||.|.|||.|||| |||.|||| |.| |.. |.||| .|.| .|
lrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkk
subfamily_PPP4C_pd Subfamily PPP4C 28-296 1.1e-102 336.2 In-house 16-284 (288) alignment 
Range on Protein: 28-296
Range on HMM: 16-284/288.0
LSEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECAS
..| |.. || |.||||. .  . ....|  .|||||||.||||.||. ||  || |||||||.||||. |.||. ||||.|..| ..  |.|||||. .
ikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrq

INRIYGFYDECKRRYT-IKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTiGWGENDRGVSFTFG
| ..||||||| |.|  ...|.  |. |. |.. ||.|.|||| ||||||.......|| | | ..||..| |||||||||.. . ||.   ||  . ||
itqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae.gwavsprgagylfg

AEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILKP
..|| .| .. |..|||||||.| .|| .  .....|..||||||    |  |.. .|..|   |.|.. 
sdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifea
subfamily_PPP2C_pd Subfamily PPP2C 26-300 1.9e-102 335.4 In-house 15-289 (290) alignment 
Range on Protein: 26-300
Range on HMM: 15-289/290.0
VQLSEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHEC
 ||.| |.. || | .|||  .  . |...|. .|||.|||..||| ||  ||  |..||||||||||||  |.||..|| | |..| |   .|||||| 
kqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhes

ASINRIYGFYDECKRRYT-IKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDkDTIGWGENDRGVSFT
  | ..||||||| |.|.  ..|| ||| |..||. |.|||.||| |||||| ......|| . |  .||..| |||||||||| |  |||  .||  .|
rqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagyt

FGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILKPVEKR
|| ..  || .. .| || ||||.| .||..  .|..||.|||||||    | .|.. .|..|  ||   .|  .|
fgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 25-297 1.1e-97 319.6 In-house 5-277 (281) alignment 
Range on Protein: 25-297
Range on HMM: 5-277/281.0
NVQLSEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHE
.||... ||  .  . . |.  .  | |...| .. ||.|.|. || ||||  | .||  ..|||||||||.||||.. ||...||.| .. .|||||||
kvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe

CASINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTIGWGENDRGVSFT
 ||.|.||||| ||. .| ..||  |  ||| ||. | ..... | ||||||.||.....| . .| . .|.||. ||||.|||... .| .  ||.|||
iasvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssft

FGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILKPV
|| .|| .  .. ...|| |||||| |||| .. |.|.|.||.||||  . ||.|.. ||.||  |.. | | 
fGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpa
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 83-297 9e-97 317.0 In-house 101-315 (317) alignment 
Range on Protein: 83-297
Range on HMM: 101-315/317.0
ANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSME
 .|||||||||||  |.| . ||.|.|..| .. ||||||||  ..|. |||| |.|.||  .|...|   ||.||..|.|..||.| |||.| .|....
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QIRRIMRPTDVPDQGLLCDLLWSDPDKDTIGWGENDRGVSFTFGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMS
|. .. ||.|.|| |.|.|| |.|||..  |. |  || .. |||. | .||.|.||||. |||||||||||||| |.|||.||||.|||..||..|..|
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDNTLMCSFQILKPV
||. |..|...|.| 
vdkklkisinvlrpe
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 29-298 6.1e-96 313.7 In-house 11-283 (287) alignment 
Range on Protein: 29-298
Range on HMM: 11-283/287.0
SEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASI
|. .|  .  | .|||   | |||.|||..|.||||||. ||||.|.  |..|. .||||||||||| .||| . ||...||.|...  |||||||.  |
sdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkki

NRIYGFYDECKRRYTIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVP--DQGLLCDLLWSDPDKDTIGWGEND-RGVSFTF
|..|||..| ||..  .|.|.| | |. ||. |.|...|.| |||.||.| |..... . .||     |.||  ||||.||.||. .   |  |..|  |
nklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvf

GAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILKPVE
| ..| ..|.| |.||| |||.|.|.||.|.....|||.|||| |.||  | ||.. |...|  ||  ||| .
GkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkped
subfamily_PPP6C_pd Subfamily PPP6C 27-300 3.1e-92 301.8 In-house 14-287 (290) alignment 
Range on Protein: 27-300
Range on HMM: 14-287/290.0
QLSEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECA
 |.| ... || .  ..|| .  .  ...|. .|||||||.|||. ||  ||  |...|.||||.||||  ||||. .||. |.|| ..  |||||||. 
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

SINRIYGFYDECKRRYT-IKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDkDTIGWGENDRGVSFTF
 | ..|||||||...|   . || .|. |. |.. ||.||...| |||||||.. ..||| | | ...| .| .|||.||||. |   |   .||  . |
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpe.dvetwavsprgagylf

GAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILKPVEKR
|..|. .|..  .|.|||||||.||.|.... . .|||..||||||    |  ........   .....| |...
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpde
subfamily_PPP3C_pd Subfamily PPP3C 27-288 1.4e-88 290.6 In-house 40-314 (452) alignment 
Range on Protein: 27-288
Range on HMM: 40-314/452.0
QLSEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECA
.|.| ..  .  .. ..|  .. |||.|||. ..||||||.||||.||| || | ...|||||||||||  |.|..  |.| ||.|....||||||||| 
rleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecr

SINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDT------IGWGEN-DR
 .   . | .||| .|. .........|..||. |..... .|.||||||...|...|... |  ..| .|.||||||||| .|         . .|  |
hlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvr

GVSFTFGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAK------RQLVTLFSAPNYCGEFDNAGAMMSVDNTLM
| |. .. . |..|||| ||  | |||.. ..||. . |        |.||||||||.. ..| .|.. ..|  |
GcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 40-296 8.1e-88 287.5 In-house 18-274 (280) alignment 
Range on Protein: 40-296
Range on HMM: 18-274/280.0
SREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYDECK
   |.. .  | | |||.|. |||| || |. |||.  |  || . .||||||||| | .| . ||.. ||.| .  .|||||||  |.|.||||| ||.
veaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecq

RRYTIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTIGWGENDRGVSFTFGAEVVVKFLQKHDL
 .| . ||  |  ||| .|. ... ....| ||||||.|  .. || | || .  |.||| ||||||| .   ||  . ||.|. ||  || .  .  ..
ykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqackslei

DLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILKP
||| ||||||.||||..| |.|.|.|| |||| .| || |.. ..  |  ||| | |
dliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlip
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 29-296 3e-85 278.7 In-house 17-288 (290) alignment 
Range on Protein: 29-296
Range on HMM: 17-288/290.0
SEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASI
|. .|  .  | .|||   | |||.|||. | ||||||  .||| |.  ||||. ..|||||||||| .|||   ||. |||.||..  |||||||.  .
sdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkv

NRIYGFYDECKRRYTIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTD--VPDQGLLCDLLWSDPDK---DTIGWgENDRGVSF
||.|||..|  |. . .||| . | |. |.. | |..||.| |||.|... | | .. . .|      |.||  ||||.||..   |||   .  |..| 
nrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtial.nkqraisv

TFGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILKP
 || ... ..|.|  |.|| |||.| |.|..|  ...|||.|||| |.|.  | ||.. | ..|  |. .|||
vfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkp
subfamily_PPG1_pd Subfamily PPG1 27-294 8.7e-85 277.6 In-house 13-293 (300) alignment 
Range on Protein: 27-294
Range on HMM: 13-293/300.0
QLSEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECA
 | |  .. |. | .|.|. .  . |...|. . ||.|||.||.| .|. ||  |..||||||||||||  |.||| ||.. |..|     |||||||  
llpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesr

SINRIYGFYDECKRRY--TIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPD---------KDTIG--
 | ..|||| || |.|    ..|| .|. |. | ..||.||.|.| ||||||.  |..||. . |  .||..| |.|||||||.          |  |  
qitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqh

WGENDRGVSFTFGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQIL
. . .||  ...| .|| |||.. |.. | ||||.. .||. .   .| |..||||||    |  ... . . .   |.. 
fvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvy
subfamily_PPP5C_pd Subfamily PPP5C 40-292 8.5e-83 271.0 In-house 46-304 (322) alignment 
Range on Protein: 40-292
Range on HMM: 46-304/322.0
SREILLAQPILLELEAP----LKICGDIHGQYYDLLRLFEYGGYPPEA-NYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGF
..|.| ..| |.|.. .    | .|||||||.|||| .||  |.| |   ||| ||.||||  |.|.| .||..|. | ..||| |||||  ..|..|||
akellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGf

YDECKRRYTIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGL-SPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKdTIGWGENDRGVSFTFGAEVVVKF
 .|.| .|| |. . ||. || ||.  ...||.. .|||| | |  .....|.| | .. |..|||..||||||.. . | ..  |||...|| .|  ||
egevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe.anGrspskrGvgvqfGpdvtkkf

LQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSV-DNTLMCSFQ
|.. .|.|| |.|.| |.|||.  . .|.|.||||||| . .| ||.... .. |   |.
lkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfk
PPP_2 58-248 7.1e-81 263.6 In-house 2-197 (198) alignment 
Range on Protein: 58-248
Range on HMM: 2-197/198.0
KICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYDECK-RRYTIKLWKTFTDCFNC
..|||.|||..|||.||..|. .|| .||||||||||||.|||...||||.|..| ....|||||||....|..|||..|.. .... |..|.....|..
tvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfel

LPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLL----WSDPDKDTIGWGENDRGVSFTFGAEVVVKFLQKHDLDLICRAHQV
||. |..|||....|||||.......||... |....|..|.|.|||    .|||.... .. .. ||....||..|. ..|.|..|.||.|||.|
LplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 58-248 6.5e-78 254.3 In-house 2-196 (197) alignment 
Range on Protein: 58-248
Range on HMM: 2-196/197.0
KICGDIHGQYYDL-LRLFEYGGYPP-EANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRYTIKLWKTFTDCFN
 ..||||||..|| |.|...|| |. | .|.||||||||||.|||...||||.|..| ....|||||||..|.|..|||..|...... ...|...|.|.
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

CLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVP-DQGLLCDL-LWSDPDKDTIGWGENDRGVSFTFGAEVVVKFLQKHDLDLICRAHQV
.||. |..|||....|||||..|.|...|.|| |....| ......|| ||||| ... |. .. ||....||..|. |||.|..|.||.|.|..
llplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 84-302 2.8e-75 246.6 In-house 121-339 (339) alignment 
Range on Protein: 84-302
Range on HMM: 121-339/339.0
NYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRYTIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQ
 |||||||||||  |.| . || | |. | .  .|||||||  |.|  |||| | . ||  .|.. | . || .|..|.... |.| |||.|  |||..|
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRRIMRPTDVPDQGLLCDLLWSDPDKDTIGWGENDRGVSFTFGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSV
.  . || ..|| |.| || |.|||    |.    || || ||   .  ||.| ||... | |||||||||||  |.|||.||||||||. ||. |..|.
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DNTLMCSFQILKPVEKRKK
|. |  | ....|  . ||
dkklkisinvfrpesrdkk
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 26-289 1e-74 244.5 In-house 18-284 (307) alignment 
Range on Protein: 26-289
Range on HMM: 18-284/307.0
VQLSEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHEC
.| .  |.  .  ... |. ..  |.... |  . ||.|||. ||. .|   | |||. |.| |||||||  |||.| ||..||| |.||  ||||||| 
iqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnhei

ASINRIYGFYDECKR---RYTIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTIGWGENDRGVS
| .|. ||||.||     .   ..|  |  ||| ||. |..  ||.| |||||| || ....|   .|   | .|.. |.||.|||   . |    ||  
arvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsg

FTFGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMC
||||..|.    ..  ..|| ||||.. |||  .. |.|.|.|||| ||  . |||... ||.||  
ftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgi
PPP_5_Dcr2 58-249 5.6e-74 241.4 In-house 2-199 (199) alignment 
Range on Protein: 58-249
Range on HMM: 2-199/199.0
KICGDIHGQYYDL-LRLFEYGGYPP-EANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYDECKRR-YTIKLWKTFTDCF
 .|||.|||..|| |.||. || |. | .|.||||||||||.|||...||||.|..| ....|||||||. ..|.||||..|.... .  |..|...|.|
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVP-DQGLLCDL-LWSDPDKDTIG-WGENDRGVSFTFGAEVVVKFLQKHDLDLICRAHQVV
..||. |..|||....||||||.. |.|....| |....| ..|  .|| ||||| ... | . .. ||....|| .|. |||.|..|.||.|.|...
dwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 50-297 7.1e-73 238.5 In-house 2-256 (263) alignment 
Range on Protein: 50-297
Range on HMM: 2-256/263.0
LLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRYTI-----
||||.||..|||| |||| ||||.|.  |   ...||||||||||| .||| | ||.. |.    ...|||||||  .||. |||. | |.|.       
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPD-QGLLCDLLWSDPDKDTIGWGEND-RGVSFTFGAEVVVKFLQKHDLDLI
 ... | . |. .|..||| ..|.| |||.|| | |...|| |  | .    . | |||||.||.||. |.  |  | .|  || . |  . .. |.|||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILKPV
 ||||||| || ||| |.|.|.|||  |  |. |  |.. |.. |  ||  ||| 
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpe
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 28-296 3.3e-68 223.1 In-house 6-299 (302) alignment 
Range on Protein: 28-296
Range on HMM: 6-299/302.0
LSEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPP-----------EANYLFLGDYVDRGKQSLETICLLLAYKIKYSENF
.|. |.  |. .  | |  .  | |. .|. | ||||||. ||.|.. .                .  ..|||||||||..|.| |||..|.|. | .|.
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

FLLRGNHECASINRIYGFYDECKRRY----TIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRP-TDVPDQGLLCDLLWSDP-DKD
 |||||||. .||  ||| .| . |.    . ..|. | ..|  .|. |.| |||.| |||.|| |.|.|.|..| || ..| .. |  |||..|| | .
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

TIG-------WGEN-DRGVSFTFGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILKP
..        . .|  ||.|..|    | .. .. .|.|| ||||..  |. |||...|.|.||||.|  | || ||.. ||     | ..|..
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 28-295 7.1e-68 222.0 In-house 7-299 (302) alignment 
Range on Protein: 28-295
Range on HMM: 7-299/302.0
LSEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPP-----------EANYLFLGDYVDRGKQSLETICLLLAYKIKYSENF
.|. |.  |. .  | |  .  | |. .|. | ||||||. ||.|.. .                .  ..|||||||||..|.| |||..|.|. | .|.
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

FLLRGNHECASINRIYGFYDECKRRY----TIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRP-TDVPDQGLLCDLLWSDP-DKD
 |||||||. .||  ||| .| . |.    . ..|. | ..|  .|. |.| |||.| |||.|| |.|.|.|..| || ..| .. |  |||..|| | .
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

TIG-------WGEN-DRGVSFTFGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSFQILK
..        . .|  ||.|..|    | .. .. .|.|| ||||..  |. |||...|.|.||||.|  | || ||.. ||     | ..|.
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_PPPLV_pd Subfamily PPPLV 35-288 2.2e-56 184.3 In-house 4-280 (290) alignment 
Range on Protein: 35-288
Range on HMM: 4-280/290.0
GLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLL----RLFEYGGYPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINR
 || .. .||.|.  ||||..|  . ||.||.| ||      |.  |     |..||||||||||. |.| |. ||| |. |   ..|||||||  |.  
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

IYGFYDECKRRYTIKL---WKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQ---IRRIMR--PTDVPDQGLLCDLLWSDPDKDT-----------
 . .. |.. ..  .|   |..|...|. ||. |..|.|.||.|.|.     .  .   |. |.   . |.    |  |.|||||..|            
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

IGWGEND-RGVSFTFGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFdNAGAMMSVDNTLM
 |. .|| || .  |... . .||.. .|. . |||.| | |...  | .|.|.||. .|||   |  |.. ||.  .
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGss.neaalilvdkkkl
Metallophos Calcineurin-like phosphoesterase 57-248 2.6e-45 148.1 Pfam-A 3-198 (200) alignment 
Range on Protein: 57-248
Range on HMM: 3-198/200.0
LKICGDIHGQYYDL----LRLFEYGGYPPEANYLFLGDYVDRGKQSLETICLL--LAYKIKYSENFFLLRGNHECASINRIYGFYDECK-----------
  ..||.||...||    |.|.. .....  ..|||||.||||. |.||..||  |..|.... ..||||||||. ..|  |||..|.            
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

-----------------------RRYTIKLWKTFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIrrimrptdvpdqgllcdllwsdpdkdtigwge
                        ... . .  . ..|..||  |.|| ||...||.||... | ..|                                
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

ndrgVSFTFGAEVVVKFLQKHDLDLICRAHQV
     |. || ... |.|.|...||..|.|. 
....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 57-189 2e-37 121.8 In-house 66-201 (383) alignment 
Range on Protein: 57-189
Range on HMM: 66-201/383.0
LKICGDIHGQYYDLLRLFEYGGYPP-EANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRY---TIKLWKTFTD
. .|||.||.  ||| ..   |.|  | .|.| ||.|||||.|.| ...|||. . | ....| |||||   .|  |||  | . .|   . |. ... |
vtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlled

CFNCLPVVAIVDEKIFCCHGGLSpDLTSMEQIRRIMR
 |  ||. ...||||. .|||.| | |..| . .| |
vfawlplatlidekilivhGGis.dktdlelldkier
subfamily_PPP7C_pd Subfamily PPP7C 199-291 9.8e-21 66.9 In-house 237-329 (383) alignment 
Range on Protein: 199-291
Range on HMM: 237-329/383.0
LCDLLWSDPDKDTIGWGENDRGVSFTFGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCSF
. |.||||| ...  . .  ||    ||..|  |.|||..|.|. |.|.   .||||  .....|.||| ||  |  | || . . ..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpri
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 28-80 2.9e-16 52.5 In-house 9-61 (317) alignment 
Range on Protein: 28-80
Range on HMM: 9-61/317.0
LSEGEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYP
..| |.  ||...||..  .|. ||||||..|.||||||. ||| |..  |.|
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 31-80 6e-12 38.3 In-house 14-63 (339) alignment 
Range on Protein: 31-80
Range on HMM: 14-63/339.0
GEIRGLCLKSREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYP
 |.  || ..||.. ..||.|.||||. . ||||||. ||| ...  |.|
aelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwp
subfamily_YNL217W_pd Subfamily YNL217W 58-177 3.1e-09 29.7 In-house 13-139 (235) alignment 
Range on Protein: 58-177
Range on HMM: 13-139/235.0
KICGDIHGQYYDLLRLFE--YGGYPPEANYLFLGDYVDRGKQSLETICLLlaykikYSENFFLLRGNHECASINRIygfydEC-------------KRRY
 . ||.|| | .|..|..   ||  ...  ...|| ...| .|.|.. ..       ...   ..|||| . . ..     .              ..  
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay.....kwvkkpkgaeplefsskfs

TI--KLWKTFTDCFNCLPVV-AIVDEKIFCCHGGLSPD
..  || |  ..    |.    |  ....  |.||.| 
flesklskadmeyarelgfsldipsdellvvhaGlvpg