Gene Pp1-87B in Drosophila melanogaster

Synonym: 13C, CG9156, DmPp1-13C, Dmel\CG9156, PP1, PP1 13C, PP1 beta13c, PP1-13C, PP13C, PP1alpha-13C, PP1alpha13C, PP1c, Pp1, pp1-13C, Dmel_CG9156, Pp1-13C

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP088_AA protein Get Run
DmelP088_AA_5-299 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP1C_pd Subfamily PPP1C 21-299 5.1e-163 534.0 In-house 3-281 (282) alignment 
Range on Protein: 21-299
Range on HMM: 3-281/282.0
RPGKNVQLSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLR
..||.|.|.| ||. |. |.|||.||||||||||||.||.|||||||.|||||||..|.|||||||||||||||||||||||.|||||||||.||.||||
kkgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllr

GNHECASINRIYGFYDECKRRYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRG
||||.|||||||||||||||||||||||||||.|||||.||.|||||.|.||||||.|.|.||||.|.||..||..|||||||||||||...||.|||||
GnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrG

VSFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPADK
||||||..||.|||||...|||.|||||||||||||||| |||.|||||||||||||||..|||..|..||||||||.|
vsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpakk
subfamily_PPZ_pd Subfamily PPZ 6-299 3.4e-140 459.8 In-house 2-296 (300) alignment 
Range on Protein: 6-299
Range on HMM: 2-296/300.0
NIDSIISRLLEVR-GARPGKNVQLSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICL
.|| || .||.    |.  ||| | . ||  .| |.||.||.|| ||||  ..|| ||.|||| ||||||   |||| .||||||||||||||||||| |
dideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletill

LLAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLW
||.||||| ||||||||||||| . |.||||||||||  ||.|||| | || ||.||||  |||| |||||| | ||..||...||||||| ||. ||||
llcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllw

SDPDKDTMGWGENDRGVSFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPADK
|||   .  | .|.||||. .    . |||.|  |||.|||| |||||||||  | |||.|||||||||||| ||.||| . |.|||..| | | 
sdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldplds
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 6-299 4.9e-136 445.6 In-house 2-296 (298) alignment 
Range on Protein: 6-299
Range on HMM: 2-296/298.0
NIDSIISRLLEVRGARPGKNVQLSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL
..|......|.|  .      ...| ..  |. ....|| .|. |.|..||.|.|||||||| ||||||. .||||..||||||||||||.|.||.|.||
evdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivll

LAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRY-SIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLW
||||.|| .|||||||||||..|||.||||.|||||| |..|...| | || ||..|.. ..|.| |||||. |.|..|.|.. ||.| ... |  ||||
laykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllw

SDPDKDTMGWGENDRGVSFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPADK
.||.. . || || ||||..||..||...|.| . ||..|||||| |||||||.. |||.||||.|||.|||. |.|.||. |..||..|||..|
adpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekk
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 5-301 7.1e-128 419.0 In-house 1-298 (299) alignment 
Range on Protein: 5-301
Range on HMM: 1-298/299.0
MNIDSIISRLLEVRGARPGKNVQLSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICL
...| ..|.||.|  .       . | |.. ||  ....|.||. |||.|||...|||||||| ||||.|.  ||||..|.||||||||||.| ||.|.|
ldvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitl

LLAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRY-SIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLL
||..|||| |.||.||||||| .|||.||||.||..|| | .||  | |.|. .|.. ..  .|.| |||||| |....|.| . || | |.  |  |||
llcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidll

WSDPDKDTMGWGENDRGVSFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPADKRK
|.|||.  ..|  | ||||. || .|||. ... . ||..||||||.|||||||.. |||.|||| |||.|||. |.| ||. |.|.|..|||..|. 
wadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpksl
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 30-297 6.3e-120 392.5 In-house 8-275 (280) alignment 
Range on Protein: 30-297
Range on HMM: 8-275/280.0
EGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASIN
| .| ..  | ..|.. |  ..|..||...|||.|||| ||||||.  .|||..||||||||||||.| || |.||||||..| .||..||||||..|||
eadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisin

RIYGFYDECKRRYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGVSFTFGAEV
| |||.||.||||| .|.. | . .. ||..|.|  .|.| |||||..| |........|| | .|. |  ||||.||.... ||.|| ||||  |||.|
rkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganv

VAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPA
| .. .| . |||.| ||||.|||||||.. |||.||||.|.|||||. |.. ||. |. ||..||||
vkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
0045823 Metallo-dependent phosphatases 14-299 3.4e-117 384.9 In-house 37-326 (473) alignment 
Range on Protein: 14-299
Range on HMM: 37-326/473.0
LlevrgarpGKNVQLSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYS
|         |. .|.| ... |. . .||. ..| ||||.... ..||||||..|||||.|  ||||| ...||||.|||| .|||...||||.|||| 
l........kkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikyp

ENFFLLRGNHECASINRIYGFYDECKRRYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPdKDTMG
.|.||||||||.. .| .|||.||. ..|...|.. | .....||.||....||...||||||||....|||.| || ..|| |||.|||||||  ...|
gnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddg

--------WGENDRGVSFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRM------LVTLFSAPNYCGEFDNAGAMMSVDDTLmCSFQILKPADK
        .| . ||....||...| .||.|. .|||.|.|..|..|||.. ..       ..|.||||||||...| .|.. .|..| .||....|.. 
dgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsph
PP2Ac_SM00156 30-297 2.4e-115 377.2 In-house 3-270 (271) alignment 
Range on Protein: 30-297
Range on HMM: 3-270/271.0
EGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASIN
. |.. |. ...||. ... |.|..||. ..||||||..|||||.| .|.|||..|.|||||||||.||.|.|.||.|.||.|.|...|||||||. |.|
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn

RIYGFYDECKRRYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGVSFTFGAEV
.||||..|.||.|. .... |...|..||.||.||.||.| ||||||.|.|...||.. |. . |..|||.|||||||.....|.  . ||.|..||...
kiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFgeda

VAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPA
| .||.|....||.|||.||..||||||.. |||.|||||||.||.|..|...|...|..|.. ||..
vkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
0049330 Metallo-dependent phosphatases 6-299 2.9e-114 374.2 In-house 8-301 (309) alignment 
Range on Protein: 6-299
Range on HMM: 8-301/309.0
NIDSIISRLLEVRGARPGKNVQLSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL
 ....| .||..   .. | ..||| |.. |.|| .||..|.|.||||.... ..||||||..|||||.|  ||||| ...||||.|||| .|||...||
lllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevllll

LAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWS
||.|..| .|.||||||||.. .|..|||.||..|.|...||. |.|....||.||....||.|.||||||||....|||...||...|. |||||||||
lalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllws

DPDKDTMGWGENDRGVSFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPADK
||. .. |...|.||....||. .| .||.|. .|||.|.|..|..||..|... |.|.||||||||...|.||.. .|..|..||....|.. 
dplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpl
PPP_1 30-283 2.3e-113 370.8 In-house 3-264 (264) alignment 
Range on Protein: 30-283
Range on HMM: 3-264/264.0
EGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASIN
| |.. |. |..|.. ....|||.......|||||||..|||.||..||..||.|||||||||||||.|.|...||||.|.|| ...||||||||.....
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

RIYGFYDECK-RRYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLL-------WSDPDKDTMGWGENDRGV
..|||..|.. ..|| ...||.||.|..||.||..||||...||||||.|....|||...| |.||..| |||||       .||........ ...||.
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

SFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSV
...||..|..|||||....||.|||.|.|.||||..|| .||.|||.||. |..|.||....
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
PPP_3 28-295 1.6e-112 367.9 In-house 2-270 (271) alignment 
Range on Protein: 28-295
Range on HMM: 2-270/271.0
LSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECAS
||| |.. |. | .||. ....|.|..||...|||||||..|||.||..||..||..||||||||||||.|||...||||.||||.....|||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INRIYGFYDECK-RRYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGVSFTFG
||..|||..|.. .... |..|.....|..||.||..|||....||||||...|..||... |...||..|.|.|||.|...... |.....||....||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

AEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILK
..|...||.|....||.|||...|.|||..... .||.|||||||....||||.......|...|..|.
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 28-296 1.4e-111 365.5 In-house 8-282 (284) alignment 
Range on Protein: 28-296
Range on HMM: 8-282/284.0
LSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFP------PESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRG
|.| |.  ||...||.|  ... ||.|||.||.||||||. ||| |..  |.|       |..|||||||||||  |.| | ||.|||... .. |||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHECASINRIYGFYDECKRRYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGV
|||   .|. |||| |||.||| .|...|  .||..|..|.|..||.| |||.| || ...|. .. ||.|.|| |...|| |.||... .|. | .|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKP
  .|||. | .||.|...||. |||||| ||||||| | |||.|||| |||..||..|...||. |..||..|||
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 32-299 7.7e-106 346.6 In-house 7-276 (284) alignment 
Range on Protein: 32-299
Range on HMM: 7-276/284.0
EIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRI
..  | ... .||  ||.|.| ..|..||||||||. ||||||.  |||  .|||||||||||||. |||| ||.|||. . . ||.|||||||. ||.|
dvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinki

YGFYDECKRRYSI-KLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQG-LLCDLLWSDPDKDTMGWGENDRGVSFTFGAEV
||||.||.|||    ....|   |  .|..|.| ..|.| |||.|  |  . |.| | || | |.   |  |.||||| .   ||  | ||||. ||.. 
ygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsda

VAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPADK
. |.|.. . ||. ||||||.|||||||.| |||.|||| |||.|||| |.| |.  |.||| .|.|  |
lrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkk
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 28-297 5.1e-105 344.0 In-house 23-295 (297) alignment 
Range on Protein: 28-297
Range on HMM: 23-295/297.0
LSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECAS
..|. .  |   . ..| .|  ..|..||.|.|||||||. ||||||  ||.|| .||||||||||||. |.||| ||||||.|.  |.|||||||||  
iteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecef

INRIYGFYDECKRRY-SIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLT---SMEQIRRIMRPTDVpDQGLLCDLLWSDPDKDTMGWGENDRGVSF
.|..||||.||..|| |.... .| | || ||.. .. .||.| |||||| ||   ... .|.| |.|.   ..|..||||.||     |. ||.||   
vnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqrgagc

TFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPA
 || . | |   . ..||.|||||||.||||||| | |||.|||| |||.|||. |.||.|. | |||.||.|.
gfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
0053225 Metallo-dependent phosphatases 10-296 6.9e-105 343.5 In-house 4-290 (293) alignment 
Range on Protein: 10-296
Range on HMM: 4-290/293.0
IISRLLEVRGARPGKNVQLSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYK
.| .||..   .  ....||| |.. |.|. .||....|.||||.... ..|||||...|||.|.|. |||||....||||.|||| .|||...||||.|
lilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalk

IKYSENFFLLRGNHECASINRIYGFYDECKRRY-SIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPD
..| .|..|||||||.. .| .|||.||..|.| . .||. ..|....||.||....||...||||||||....|||.|.||...|. |||.||||||||
llypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd

kDTMGWGENDRGVSFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKP
 . .||. . ||....||. .| .||.|. .|||.|.|||| |||... .. |||.||||||.|...|.||.. .|. |...|....|
.lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap
subfamily_PPP4C_pd Subfamily PPP4C 28-297 4.5e-103 337.4 In-house 16-285 (288) alignment 
Range on Protein: 28-297
Range on HMM: 16-285/288.0
LSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECAS
..| |.. || |.|||.. .  . ....|  .|||||||.||||.||. ||  || |||||||.||||. |.||. ||||.|..| ..  |.|||||. .
ikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrq

INRIYGFYDECKRRY-SIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDkDTMGWGENDRGVSFTFG
| ..||||||| |.| |...|.  |. |. |..|||.|.|||| ||||||.......|| | | ..||..| |||||||||. |. ||.   ||  . ||
itqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpe.daegwavsprgagylfg

AEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPA
..||..| .. ...|||||||.| .|| .  .. ..|..||||||    |  |.. .|..|   |.|.. |
sdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaa
subfamily_PPP2C_pd Subfamily PPP2C 26-300 2.3e-102 335.1 In-house 15-289 (290) alignment 
Range on Protein: 26-300
Range on HMM: 15-289/290.0
VQLSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHEC
 ||.| |.. || | .||. ..  . |...|. .|||.|||..||| ||  ||  |..||||||||||||  |.||..|| | |..| |   .|||||| 
kqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhes

ASINRIYGFYDECKRRYS-IKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDkDTMGWGENDRGVSFT
  | ..||||||| |.|.  ..|| ||| |..||..|.|||.||| |||||| ......|| . |  .||..| |||||||||| |  |||  .||  .|
rqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagyt

FGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPADKR
|| ..  || .. .. || ||||.| .||..  .| .||.|||||||    | .|.. .||.|  ||   .|| .|
fgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 25-298 8.3e-100 326.6 In-house 5-278 (281) alignment 
Range on Protein: 25-298
Range on HMM: 5-278/281.0
NVQLSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHE
.||... ||  .  . . || ..  | |...| .. ||.|.|. || ||||  | .||  ..|||||||||.||||.. ||...||.| .. .|||||||
kvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe

CASINRIYGFYDECKRRYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGVSFT
 ||.|.||||| ||. .| ..||  |  ||| ||..| ..... | ||||||.||.....| . .| . .|.||. ||||.|||.....| .  ||.|||
iasvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssft

FGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPAD
|| .|| .  .. | .|| |||||| |||| .. | |.|.||.||||  . ||.|.. ||.||  |.. | || 
fGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpas
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 83-297 1.8e-96 316.1 In-house 101-315 (317) alignment 
Range on Protein: 83-297
Range on HMM: 101-315/317.0
SNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSME
..|||||||||||  |.| . ||.|.|..| .. ||||||||  ..|. |||| |.|.||| .|...|   ||.||..|.|..||.| |||.| .|....
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGVSFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMS
|. .. ||.|.|| |.|.|| |.|||..  |. |  || .. |||. | .||.|...||. |||||||||||||| | |||.||||.|||..||..|..|
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDDTLMCSFQILKPA
||. |..|...|.| 
vdkklkisinvlrpe
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 29-299 1.1e-94 309.5 In-house 11-284 (287) alignment 
Range on Protein: 29-299
Range on HMM: 11-284/287.0
SEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASI
|. .|  .  | .||.   | |||.|||..|.||||||. ||||.|.  | .|. .||||||||||| .||| . ||...||.|...  |||||||.  |
sdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkki

NRIYGFYDECKRRYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVP--DQGLLCDLLWSDPDKDTMGWGEND-RGVSFTF
|..|||..| ||... .|.|.| | |. ||. |.|...|.| |||.||.| |..... . .||     |.||  ||||.||.||. .   |  |..|  |
nklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvf

GAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPADK
| ..| ..|.| . ||| |||.|.|.||.|.... |||.|||| |.||  | ||.. |...|  ||  ||| | 
GkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedf
subfamily_PPP6C_pd Subfamily PPP6C 27-295 1.1e-91 300.0 In-house 14-282 (290) alignment 
Range on Protein: 27-295
Range on HMM: 14-282/290.0
QLSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECA
 |.| ... || .  ...| .  .  ...|. .|||||||.|||. ||  ||  |...|.||||.||||  ||||. .||. |.|| ..  |||||||. 
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

SINRIYGFYDECKRRYS-IKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDkDTMGWGENDRGVSFTF
 | ..|||||||...|   . || .|. |. |..|||.||...| |||||||.. ..||| | | ...| .| .|||.||||. |   |   .||  . |
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpe.dvetwavsprgagylf

GAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILK
|..|. .|..  ...|||||||.||.|.... .  |||..||||||    |  ......|.   .....|
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 37-297 4.7e-89 291.6 In-house 15-275 (280) alignment 
Range on Protein: 37-297
Range on HMM: 15-275/280.0
CLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYD
      ||. .  | | |||.|. |||| || |. |||.  |  || . .||||||||| | .| . ||.. ||.| .  .|||||||  |.|.||||| 
irmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyv

ECKRRYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGVSFTFGAEVVAKFLQK
||. .| . ||  |  ||| .|..... ....| ||||||.|  .. || | || .  |.||| ||||||| .   ||  . ||.|. ||  || .  . 
ecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqacks

HEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPA
 | ||| ||||||.||||..| | |.|.|| |||| .| || |.. ..  |  ||| | | 
leidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
subfamily_PPP3C_pd Subfamily PPP3C 27-288 1.4e-88 290.7 In-house 40-314 (452) alignment 
Range on Protein: 27-288
Range on HMM: 40-314/452.0
QLSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECA
.|.| ..  .  .. ... ... |||.|||. ..||||||.||||.||| || | ...|||||||||||  |.|..  |.| ||.|....||||||||| 
rleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecr

SINRIYGFYDECKRRYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMG------WGEN-DR
 .   . | .||| .|| .........|..||.||..... .|.||||||...|...|... |  ..| .|.||||||||| .|         . .|  |
hlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvr

GVSFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAK------RMLVTLFSAPNYCGEFDNAGAMMSVDDTLM
| |. .. . |..|||| ..  | |||.. ..||. . |        |.||||||||.. ..| .|.. ...  |
GcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
subfamily_PPG1_pd Subfamily PPG1 27-298 1.3e-84 277.0 In-house 13-297 (300) alignment 
Range on Protein: 27-298
Range on HMM: 13-297/300.0
QLSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECA
 | |  .. |. | .|.....  . |...|. . ||.|||.||.| .|. ||  |..||||||||||||  |.||| ||.. |..|     |||||||  
llpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesr

SINRIYGFYDECKRRY--SIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPD---------KDTMG--
 | ..|||| || |.|    ..|| .|. |. | .|||.||.|.| ||||||.  |..||. . |  .||..| |.|||||||.          |  |  
qitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqh

WGENDRGVSFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPAD
. . .||  ...| .|| |||.. ... | ||||.. .||. .   .| |..||||||    |  ... . . .   |.. . | 
fvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeap
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 29-297 1.5e-83 273.1 In-house 17-289 (290) alignment 
Range on Protein: 29-297
Range on HMM: 17-289/290.0
SEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASI
|. .|  .  | .||.   | |||.|||. | ||||||  .||| |.  |.||. ..|||||||||| .|||   ||. |||.||..  |||||||.  .
sdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkv

NRIYGFYDECKRRYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTD--VPDQGLLCDLLWSDPDK---DTMGWgENDRGVSF
||.|||..|  |. . .||| . | |. |.. | |..||.| |||.|... | | .. . .|      |.||  ||||.||..   ||.   .  |..| 
nrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtial.nkqraisv

TFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPA
 || ... ..|.|  ..|| |||.| |.|..|  .. |||.|||| |.|.  | ||.. | ..|  |. .||| 
vfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
subfamily_PPP5C_pd Subfamily PPP5C 39-286 1.4e-82 270.2 In-house 45-298 (322) alignment 
Range on Protein: 39-286
Range on HMM: 45-298/322.0
KSREIFLSQPILLELEAP----LKICGDIHGQYYDLLRLFEYGGFPPES-NYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYG
...|.. ..| |.|.. .    | .|||||||.|||| .||  | | |.  ||| ||.||||  |.|.| .||..|. | ..||| |||||  ..|..||
eakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyG

FYDECKRRYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGL-SPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKdTMGWGENDRGVSFTFGAEVVAK
| .|.| .|. |. . ||. || ||.| ...||.. .|||| | |  .....|.| | .. |..|||..||||||.. ..| ..  |||...|| .|  |
fegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe.anGrspskrGvgvqfGpdvtkk

FLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSV-DDT
||.. ...|| |.|.| |.|||.  .  |.|.||||||| . .| ||.... .| 
flkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgdd
PPP_2 58-248 4.1e-82 267.7 In-house 2-197 (198) alignment 
Range on Protein: 58-248
Range on HMM: 2-197/198.0
KICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYDECK-RRYSIKLWKTFTDCFNC
..|||.|||..|||.||..|...||..||||||||||||.|||...||||.|..| ....|||||||....|..|||..|.. .... |..|.....|..
tvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfel

LPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLL----WSDPDKDTMGWGENDRGVSFTFGAEVVAKFLQKHEFDLICRAHQV
||.||..|||....|||||.......||... |....|..|.|.|||    .|||.... .. .. ||....||..|....|.|....||.|||.|
LplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 58-248 4e-79 258.2 In-house 2-196 (197) alignment 
Range on Protein: 58-248
Range on HMM: 2-196/197.0
KICGDIHGQYYDL-LRLFEYGGFPP-ESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRYSIKLWKTFTDCFN
 ..||||||..|| |.|...||.|. |..|.||||||||||.|||...||||.|..| ....|||||||..|.|..|||..|...... ...|...|.|.
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

CLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVP-DQGLLCDL-LWSDPDKDTMGWGENDRGVSFTFGAEVVAKFLQKHEFDLICRAHQV
.||.||..|||....|||||..|.|...|.|| |....| ......|| ||||| ... |. .. ||....||..|. |||.|....||.|.|..
llplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 25-292 4.2e-76 249.1 In-house 17-287 (307) alignment 
Range on Protein: 25-292
Range on HMM: 17-287/307.0
NVQLSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHE
..| .  |.  .  ... || |.  |.... |  . ||.|||. ||. .|   | |||. |.| |||||||  |||.| ||..||| |.||  |||||||
kiqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnhe

CASINRIYGFYDECKR---RYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGV
 | .|. ||||.||     .   ..|  |  ||| ||..|..  ||.| |||||| || ....|   .|   | .|.. |.||.|||   . |    || 
iarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgs

SFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQ
 ||||..|.    ..   .|| ||||.. |||  .. | |.|.|||| ||  . |||... ||.||     
gftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlv
PPP_5_Dcr2 58-249 3.2e-75 245.5 In-house 2-199 (199) alignment 
Range on Protein: 58-249
Range on HMM: 2-199/199.0
KICGDIHGQYYDL-LRLFEYGGFPP-ESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYDECKRR-YSIKLWKTFTDCF
 .|||.|||..|| |.||. ||.|. | .|.||||||||||.|||...||||.|..| ....|||||||. ..|.||||..|.... .. |..|...|.|
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVP-DQGLLCDL-LWSDPDKDTMG-WGENDRGVSFTFGAEVVAKFLQKHEFDLICRAHQVV
..||.||..|||....||||||.. |.|....| |....| ..|  .|| ||||| ... | . .. ||....|| .|. |||.|....||.|.|...
dwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 84-302 3.5e-74 242.9 In-house 121-339 (339) alignment 
Range on Protein: 84-302
Range on HMM: 121-339/339.0
NYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQ
 |||||||||||  |.| . || | |. | .  .|||||||  |.|  |||| | . ||  .|.. | . || .|..|.... |.| |||.|  |||..|
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGVSFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSV
.  . || ..|| |.| || |.|||    |.    || || ||   .  ||.| ..... | |||||||||||  | |||.||||||||. ||. |..|.
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DDTLMCSFQILKPADKRKK
|  |  | ....|  . ||
dkklkisinvfrpesrdkk
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 50-298 1.6e-72 237.4 In-house 2-257 (263) alignment 
Range on Protein: 50-298
Range on HMM: 2-257/263.0
LLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRYSI-----
||||.||..|||| |||| ||||.|.  |   ...||||||||||| .||| | ||.. |.    ...|||||||  .||. |||. | |.|.       
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPD-QGLLCDLLWSDPDKDTMGWGEND-RGVSFTFGAEVVAKFLQKHEFDLI
 ... | . |. .|..||| ..|.| |||.|| | |...|| |  | .    . | |||||.||.||. |.  |  | .|  || . |  . .. . |||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPAD
 ||||||| || ||| | |.|.|||  |  |. |  |.. |.  |  ||  ||| |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkped
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 28-295 2.1e-68 223.7 In-house 6-298 (302) alignment 
Range on Protein: 28-295
Range on HMM: 6-298/302.0
LSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYG------------GFpPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSEN
.|. |.  |. .  | .  .  | |. .|. | ||||||. ||.|.. .             .|  .. ..|||||||||..|.| |||..|.|. | .|
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlyptn

FFLLRGNHECASINRIYGFYDECKRRYS----IKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRP-TDVPDQGLLCDLLWSDP-DK
. |||||||. .||  ||| .| . |..     ..|. | ..|  .|.||.| |||.| |||.|| |.|.|.|..| || ..| .. |  |||..|| | 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

D-------TMGWGEN-DRGVSFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILK
.       .  . .|  ||.|..|    | .. .. ...|| ||||..  |. |||.. |.|.||||.|  | || ||.. ||     | ..|.
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 27-295 4.1e-68 222.8 In-house 6-299 (302) alignment 
Range on Protein: 27-295
Range on HMM: 6-299/302.0
QLSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYG------------GFpPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSE
..|. |.  |. .  | .  .  | |. .|. | ||||||. ||.|.. .             .|  .. ..|||||||||..|.| |||..|.|. | .
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlypt

NFFLLRGNHECASINRIYGFYDECKRRYS----IKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRP-TDVPDQGLLCDLLWSDP-D
|. |||||||. .||  ||| .| . |..     ..|. | ..|  .|.||.| |||.| |||.|| |.|.|.|..| || ..| .. |  |||..|| |
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

KD-------TMGWGEN-DRGVSFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILK
 .       .  . .|  ||.|..|    | .. .. ...|| ||||..  |. |||.. |.|.||||.|  | || ||.. ||     | ..|.
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_PPPLV_pd Subfamily PPPLV 35-287 2.5e-56 184.1 In-house 4-279 (290) alignment 
Range on Protein: 35-287
Range on HMM: 4-279/290.0
GLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLL----RLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINR
 || .. .|....  ||||..|  . ||.||.| ||      |.  |     ...||||||||||. |.| |. ||| |. |   ..|||||||  |.  
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

IYGFYDECKRRYSIKL---WKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQ---IRRIMR--PTDVPDQGLLCDLLWSDPDKD-----------T
 . .. |.. ..  .|   |..|...|. ||.||..|.|.||.|.|.     .  .   |. |.   . |.    |  |.|||||..|            
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

MGWGEND-RGVSFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAgAMMSVDDTL
 |. .|| || .  |... . .||.. . . . |||.| | |...  |  |.|.||. .|||  ..| |.. ||   
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssnea.alilvdkkk
Metallophos Calcineurin-like phosphoesterase 57-248 1.5e-44 145.7 Pfam-A 3-198 (200) alignment 
Range on Protein: 57-248
Range on HMM: 3-198/200.0
LKICGDIHGQYYDL----LRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL--LAYKIKYSENFFLLRGNHECASINRIYGFYDECK-----------
  ..||.||...||    |.|.. .. ..  ..|||||.||||. |.||..||  |..|.... ..||||||||. ..|  |||..|.            
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

-----------------------RRYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIrrimrptdvpdqgllcdllwsdpdkdtmgwge
                        ..  . .  . ..|..|| .|.|| ||...||.||... | ..|                                
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

ndrgVSFTFGAEVVAKFLQKHEFDLICRAHQV
     |. || ... |.|.|.  ||..|.|. 
....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 57-189 3.6e-38 124.3 In-house 66-201 (383) alignment 
Range on Protein: 57-189
Range on HMM: 66-201/383.0
LKICGDIHGQYYDLLRLFEYGGFPPE-SNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRY---SIKLWKTFTD
. .|||.||.  ||| ..   |.| |  .|.| ||.|||||.|.| ...|||. . | ....| |||||   .|  |||  | . .|   . |. ... |
vtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlled

CFNCLPVAAIVDEKIFCCHGGLSpDLTSMEQIRRIMR
 |  ||.|...||||. .|||.| | |..| . .| |
vfawlplatlidekilivhGGis.dktdlelldkier
subfamily_PPP7C_pd Subfamily PPP7C 199-291 9.4e-21 66.9 In-house 237-329 (383) alignment 
Range on Protein: 199-291
Range on HMM: 237-329/383.0
LCDLLWSDPDKDTMGWGENDRGVSFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSF
. |.||||| ...  . .  ||    ||..| .|.|||....|. |.|.   .||||  .. ..|.||| ||  |  | || . . ..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpri
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 28-81 4.9e-17 55.1 In-house 9-62 (317) alignment 
Range on Protein: 28-81
Range on HMM: 9-62/317.0
LSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPP
..| |.  ||...||.| ..|. ||||||..|.||||||. ||| |..  |.| 
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 31-82 2.5e-12 39.6 In-house 14-65 (339) alignment 
Range on Protein: 31-82
Range on HMM: 14-65/339.0
GEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPE
 |.  || ..||.  |.||.|.||||. . ||||||. ||| ...  |.|  
aelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwpls
subfamily_YNL217W_pd Subfamily YNL217W 58-181 9.2e-09 28.1 In-house 13-127 (235) alignment 
Range on Protein: 58-181
Range on HMM: 13-127/235.0
KICGDIHGQYYDLLRLFE--YGGFPPESNYLFLGDYVDRGKQSLETICLLlaykikYSENFFLLRGNHECASINRIygfydECKRRYSIKLWKTFTDCFN
 . ||.|| | .|..|..   ||  ..   ...|| ...| .|.|.. ..       ...   ..|||| . . ..     .  ..      ..|.. |.
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay.....kwvkkpkgaeplefsskfs

CLPVAAIVDEKIFCCHGGLSPDLTSM
 |. .   .. ..    | | |..| 
flesklskadmeyarelgfsldipsd