Gene Pp1-Y1 in Drosophila melanogaster

Synonym: 87B, CG5650, DmPp1-87B, Dmel\CG5650, PP-1alpha, PP1, PP1 87B, PP1 beta87b, PP1-87B, PP187B, PP1A87B, PP1B, PP1alpha-87B, PP1alpha87B, PP1alpha[[2]], PP1c, PP1c 87B, PPI 87B, Pp-1alpha, Pp1, Pp1-87Bb, Pp1alpha-87B, Ppl-87B, Su(Var)3-6, Su(var)(3)6, Su(var)3-6, Su-var(3)6, Suvar(3)6, ck19, dPP1beta, l(3)87Bg, l(3)ck19, l(3)j6E7, pp1-87B, su-var(3)6, Dmel_CG5650, Pp1-87B

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP089_AA protein Get Run
DmelP089_AA_19-209 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP1C_pd Subfamily PPP1C 27-209 1.1e-91 300.0 In-house 2-184 (282) alignment 
Range on Protein: 27-209
Range on HMM: 2-184/282.0
WKIDRKMMVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLL
.| ...... |..| .|||.||..|.|.|.||..||||...|||||||.||||.|||||.||...||.||||||||| |.||..||||||..||....||
skkgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfll

RGNHESAAINRYYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
||||||| |||.||||||||||..|.||..|.|...|||.||....||...||||||.|..|..|...||| ||...||||||
rGnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdl
0045823 Metallo-dependent phosphatases 23-209 2.2e-70 230.6 In-house 31-217 (473) alignment 
Range on Protein: 23-209
Range on HMM: 31-217/473.0
SLLSWKIDRKMMVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTS
.||   . .  ..||.|..|||..|...|..||.|| ..... |.||||||. |||| .|  |.||. |...|||.|||| .|.|.| ||||.|..||..
dlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgn

IHLLRGNHESAAINRYYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
..|||||||....| .|||.||. ......|...|... ..||.||.|..||. .||||||.|..|..| ...|| |....|||.||
vfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldl
PPP_1 37-209 4.9e-70 228.8 In-house 3-176 (264) alignment 
Range on Protein: 37-209
Range on HMM: 3-176/264.0
ESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAIN
|. ...|.|.....|..|..||.|.... | ||||||..|||. |...|..|...|| |||||||||.|||.|.||||.|..|| ...||||||||. ..
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

RYYGFYDECK-RRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
..|||..|.. .... .......|..|.||.||.|. ||. .||||||.|. |..|....|  ||  .| ||||
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdl
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 18-209 5.3e-69 225.5 In-house 4-199 (298) alignment 
Range on Protein: 18-209
Range on HMM: 4-199/298.0
DEMIASLLSWKID---RKMMVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLA
||.....||  .       .. |.|. ||...|.... . ..|. |.||..| |||||||.|||| |. .|.||.. ||.||||||||....|...||||
dellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivllla

YKVRYPTSIHLLRGNHESAAINRYYGFYDECKRRF-TIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
|||.||. . ||||||| .|||| ||||.|||||.  .||.  | | .. ||..|.| ..|.  |||||. |..|.....|.|| . . . |  ||
ykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidl
PPP_3 35-209 6.8e-69 224.9 In-house 2-177 (271) alignment 
Range on Protein: 35-209
Range on HMM: 2-177/271.0
VPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAA
..|... .|.|.....|..|..|....|||.|.||||||..|||. |...|..|...|| |||||||||.|.|.|.||||.|..||...|||||||||. 
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INRYYGFYDECK-RRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
||..|||..|.. .. . ...... .....||.||.|..|.. .|||||||...|..|..|.|. ||  .|.|.||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldl
PP2Ac_SM00156 37-209 7.9e-69 224.7 In-house 3-175 (271) alignment 
Range on Protein: 37-209
Range on HMM: 3-175/271.0
ESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAIN
......||......|..|..|. |.||| | ||||||..|||| .|. | ||...|..||||||||..|.|...||.|.|..||. ..||||||||  .|
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn

RYYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
..|||..|.||. . ... .| .....||.||...|||.  ||||||.|..|.||..|.|..|  ..|||.||
kiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidl
subfamily_PPZ_pd Subfamily PPZ 27-209 1.4e-67 221.4 In-house 17-199 (300) alignment 
Range on Protein: 27-209
Range on HMM: 17-199/300.0
WKIDRKMMVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLL
 |  ... . .|.|... ..||......| || .  .|...||.||||.|||| |   | ||.  ||.||||||||| |.||. |||.||..||  . ||
akrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffll

RGNHESAAINRYYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
||||| | . | ||||||||||  |..|. ||| .. ||.|||.  |||  |||||| | ....|.|. ||..|   ||. ||
rgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindl
0049330 Metallo-dependent phosphatases 20-209 3e-67 220.0 In-house 12-204 (309) alignment 
Range on Protein: 20-209
Range on HMM: 12-204/309.0
MIASLLSWKID---RKMMVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYK
.| |||.. |.   .  ...|.....|| .|...|.|||.|| ..... | ||||||. |||| .|  | ||  |...|||.|||| .|.|.|.||||.|
lilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalk

VRYPTSIHLLRGNHESAAINRYYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
..|| ...|||||||....|..|||.||..|.. ..||..|.|....||.||.|..||. .||||||.|..|..|..|.|| |..  ||||||
llypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdl
subfamily_PPP4C_pd Subfamily PPP4C 30-209 7.1e-66 215.4 In-house 11-191 (288) alignment 
Range on Protein: 30-209
Range on HMM: 11-191/288.0
DRKMMVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGN
 |  .. |... .| ..||..|. |  . .|..|| | ||||||..|||. |. .|. |...||.|||.||||.|||||. ||||.|||||  |.|.|||
rrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgn

HESAAINRYYGFYDECKRRF-TIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
|||  | . ||||||| |.. ....||. .. .| |..||||. |||  |||||||...|..|. ..|  || ..| ||||
hesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdl
subfamily_PPP3C_pd Subfamily PPP3C 24-209 5e-65 213.0 In-house 30-215 (452) alignment 
Range on Protein: 24-209
Range on HMM: 30-215/452.0
LLSWKIDRKMMVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSI
.|  .. ..  . |....|....| ..| .|. ||.||||. |.||||||. |||. || .|.| . .||.|||||||| .|.|..  |.| |. ||...
vlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstl

HLLRGNHESAAINRYYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
.|||||||.  .  |. | .||| ... ... ......|.||.||..| . . .|||||| ...|.||..|.|  |..  |.||||
fllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdl
0053225 Metallo-dependent phosphatases 29-209 3.1e-63 207.0 In-house 16-197 (293) alignment 
Range on Protein: 29-209
Range on HMM: 16-197/293.0
IDRKMMVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRG
. . ....|.....|| .|...|..||.|| ..... |.|||||.. |||. .|  | ||  |...|||.|||| .|.|.|.||||.|..||....||||
llllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrG

NHESAAINRYYGFYDECKRRF-TIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
|||.. .| .|||.||..|..   .||....|....||.||.|..||. .||||||.|..|..| ...|| ... .|||.||
NHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldl
subfamily_PPP2C_pd Subfamily PPP2C 31-209 1e-62 205.0 In-house 13-192 (290) alignment 
Range on Protein: 31-209
Range on HMM: 13-192/290.0
RKMMVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNH
.   . ||.. .| ..|...|..|  .  |..|| | ||.|||. |||  |   |. |.  ||.|||||||| |||||.||| | ||||.  | .|||||
eckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnh

ESAAINRYYGFYDECKRRFT-IRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
||  | . ||||||| |...   .|..| | .|.||..|.....||  |||||||.. |..|..|.|  || ..| ||||
esrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdl
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 36-208 2.9e-61 199.9 In-house 11-185 (287) alignment 
Range on Protein: 36-208
Range on HMM: 11-185/287.0
PESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAI
 ..||...|......|   | || ||||....||||||..||||.|.  |..|| .||.||||||||  |.|   ||...|..|| ..||||||||  .|
sdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkki

NRYYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDR--NGLLCD
|. |||..| ||..  ||.. | | .. ||. |... .|.  |||.|| |. |.... |..|       .||  |
nklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvd
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 18-205 1.1e-60 198.5 In-house 4-195 (299) alignment 
Range on Protein: 18-205
Range on HMM: 4-195/299.0
DEMIASLLSWKIDRKM---MVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLA
||... ||.     |     | | ....| . |..|..|.. || ||||. | ||||||| |||| |. .| ||.  .|.||||||||.  .|..||||.
dellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllc

YKVRYPTSIHLLRGNHESAAINRYYGFYDECKRRFT-IRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGL
.|..||  ...||||||  |||| ||||.||..|..  ||| .| |... .|.. .|.|.|.  |||||| |..|. ...|.|| .     |
fkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpsl
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 35-209 5.4e-60 195.9 In-house 6-180 (280) alignment 
Range on Protein: 35-209
Range on HMM: 6-180/280.0
VPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAA
. | || ..... ...|. .  .. |.|||.| ||.||||.|||| |.  . || . ||.||||||||.. .| . |||||||||| .. .|||||| . 
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

INRYYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
||| |||.||.|||..  |.  | . .| ||..|... .|.  |||||. |  |.|...|.|| . . . |  ||
inrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdl
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 33-209 6.9e-59 192.6 In-house 6-188 (284) alignment 
Range on Protein: 33-209
Range on HMM: 6-188/284.0
MMVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHP------PKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLL
 .. | ..|.|  .||...  |.. | .||||.. ||||||..|||  ..  |.|       .|.||.|||||||| .|.| .|||.|||...|  . ||
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHESAAINRYYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
||||||  .|. |||| |||.|.. .|. .|  .. ..|..|....||.  |||.|  | .|.....|.|| ..   |...||
rgnhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadl
subfamily_PPP6C_pd Subfamily PPP6C 33-209 9.1e-59 191.9 In-house 13-190 (290) alignment 
Range on Protein: 33-209
Range on HMM: 13-190/290.0
MMVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHES
 ..||.|. || ..  ..|. |  . .|..|| | ||||||. ||.  | |.|. |...|..|||.|||| ||.||.|.||. |..||  | ||||||||
kylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhes

AAINRYYGFYDECKRRFT-IRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
  | . |||||||....     |. ... .| |..||||. ...  |||||| .. |..|. ..|  |. ..| .|||
rqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdl
PPP_2 64-208 3.5e-58 189.6 In-house 1-146 (198) alignment 
Range on Protein: 64-208
Range on HMM: 1-146/198.0
VNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAINRYYGFYDECK-RRFTIRLWRMFVDCYD
|.|.||.|||..|||. |......|...|| |||||||||.|.|.|.||||.|..||...|||||||||. .|..|||..|.. .. . ...... ....
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

CLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCD
.||.||.|..|.. .|||||.....|..|.. .|. |.  .|.|.|
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklld
subfamily_PPG1_pd Subfamily PPG1 28-209 1.9e-57 187.8 In-house 7-190 (300) alignment 
Range on Protein: 28-209
Range on HMM: 7-190/300.0
KIDRKMMVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLR
|. .  ..||. . .| .. ...|..|  .  ...|| |.||.|||. |.|  |.  |. |   ||.|||||||| |||||..||.. |.|||. |.|||
klqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllr

GNHESAAINRYYGFYDECKRRF--TIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
|||||  | . |||| || |..    |.|. . . .| | .||||. .|.  |||||||   ...|. |.|  || ..| |.||
gnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladl
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 33-209 2.8e-57 187.1 In-house 6-182 (281) alignment 
Range on Protein: 33-209
Range on HMM: 6-182/281.0
MMVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHES
. . . .|........ ....|  |  ...|. |.||.|.|.||| | ||  | .|......||||||||. |.|.| ||...|.||.  | ||||||| 
vqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhei

AAINRYYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
|..|. |||| ||. .. . ||  |  |.. ||..| |. ..   |||||| | .|....   .| .    ||. ||
asvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDl
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 20-199 5.7e-56 182.7 In-house 3-180 (290) alignment 
Range on Protein: 20-199
Range on HMM: 3-180/290.0
MIASLLSWKIDRKmmVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRY
||  || . .       ..||...|......|   | || ||||. ..|||||| ..|||||.  |.||| ..|.||||||||  |.|   ||. ||.||
miehllkygvlda..fsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiry

PTSIHLLRGNHESAAINRYYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAE
. ..||||||||   .|| |||..|  |. . |||... | .. |.. | .. ||.  |||.|. ..  . .. |..|  
skkvhllrgnhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprv
PPP_4 64-208 1.6e-54 178.0 In-house 1-148 (197) alignment 
Range on Protein: 64-208
Range on HMM: 1-148/197.0
VNVLGDIHGQYNDL-LRYFETSGHPP-KKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAINRYYGFYDECKRRFTIRLWRMFVDCY
| | ||||||..|| |. ....|.|. ...|. |||||||||.|.|.|.||||.|..||. ..||||||||...|..|||..|.... . ...... |..
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

DCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVD-RNGLLCD
|.||.||.|..|.. .|||||..|..|..|....|. |.. ......|
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkd
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 19-208 4.7e-54 176.7 In-house 4-199 (297) alignment 
Range on Protein: 19-208
Range on HMM: 4-199/297.0
EMIASLLSWKIDRKM---MVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAY
..|  .||     |.   .. |  ..|||  | .|. ..  .. |.||..| ||||||. |||| |   | ||   ||.||||||||..|.||. |||||
siiidvlsasthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllay

KVRYPTSIHLLRGNHESAAINRYYGFYDECKRRF-TIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPS---LHNLNDIQHLQRPAEVdRNGLLCD
||..|. . |||||||   .|. ||||.||..|. ..|..  | | .. ||.. .| .||.  ||||||       |. .....|. |  ...|..|
kvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvad
PPP_5_Dcr2 64-207 3.4e-52 170.3 In-house 1-148 (199) alignment 
Range on Protein: 64-207
Range on HMM: 1-148/199.0
VNVLGDIHGQYNDLLRYFETSG-HPP-KKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAINRYYGFYDECKRR-FTIRLWRMFVDC
| |.||.|||..||| ...  | .|. ...|. |||||||||.|.|.|.||||.|..||  .||||||||. ..|..|||..|....    ...... |.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

YDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVD-RNGLLC
.|.||.||.|..|.. .||||||............|. |.   .|  .
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgeka
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 34-200 4.6e-51 166.9 In-house 2-169 (284) alignment 
Range on Protein: 34-200
Range on HMM: 2-169/284.0
MVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESA
..|  |.  || .| ...  .|||. |..|.|. ||||||. |||| |.  | | .  ||.|||||||||. .||. ||.|||| .|  . .|||||| .
lippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecs

AINRYYGFYDECKRRFTI-RLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEV
 ||. ||||.||.||.    ..  |   .  .|..|..  .|.  |||.|  |.|. ... ..|| . 
linkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdn
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 38-209 8.2e-50 162.8 In-house 9-180 (280) alignment 
Range on Protein: 38-209
Range on HMM: 9-180/280.0
SDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAINR
 .|| ...    ..| |  |   |||..|.|||| ||.|. | |.  |. |... ..||||||||   .| | ||.. |.||   |.|||||||. ..|.
heiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnk

YYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDL
 |||| ||. .. . ||  |  |.. .|....|. ...  |||||| | ||. |. . ||.|    ||| ||
iygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidl
subfamily_PPP5C_pd Subfamily PPP5C 18-209 1.3e-49 162.0 In-house 18-214 (322) alignment 
Range on Protein: 18-209
Range on HMM: 18-214/322.0
DEMIASLLSWKIDRKMmVPESDIIKLLKQARQVLMSEPMLLTVEAP----VNVLGDIHGQYNDLLRYFETSGHPP-KKRYLMLGDYVDRGKYSVETLTLL
 |..  ||..  ..|. ...  ..|.|..|...| ..| |. .. .    . | ||||||. |||  ||  |.|  .. ||. ||.|||| .|||.. .|
kefvkellelfkkqkk.lhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltl

LAYKVRYPTSIHLLRGNHESAAINRYYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSP-SLHNLNDIQHLQRPAEVDRNGLLCDL
|..|. || ...| ||||||  .|. ||| .|.| ..| ..  .| . .. ||.| .||.|.. .||||      .|.|.....| |.  ..|||..|
lgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvel
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 89-209 6e-45 146.8 In-house 100-220 (317) alignment 
Range on Protein: 89-209
Range on HMM: 100-220/317.0
KKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAINRYYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNL
.|.||.|||||||| .|.| ..||.|.|..||  ..|||||||| ..|. |||| |.|.|.  .|. .|   . .||..|..|.||.  |||.| .| .|
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldl

NDIQHLQRPAEVDRNGLLCDL
. ...|.|| ..   |.|.||
kqldklkrpldipdvGvladl
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 57-209 7.6e-43 140.0 In-house 2-160 (263) alignment 
Range on Protein: 57-209
Range on HMM: 2-160/263.0
LLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAINRYYGFYDECKRRFTI-----
|| ..||.|. || ||||||||| |.. |   | .||.|||||||| .|.| . ||.. |.  |  .||||||||  |||. |||. | |.||       
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

RLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRN-GLLCDL
 ..  | . .  .|..||.. .|.  |||.|| |..|.||. .  | |  .   | |||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdl
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 33-206 2.2e-42 138.3 In-house 18-194 (307) alignment 
Range on Protein: 33-206
Range on HMM: 18-194/307.0
MMVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHES
.     .. ... .|. .. ||  |. .. |. |.||.|||.|||.  |   | ||.  |.. |||||||  |.|.. ||..||. || .| ||||||| 
iqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnhei

AAINRYYGFYDECKRR---FTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPAEVDRNGLL
| .|. ||||.||          .| .|  |.. ||..|.| .||.  ||||||.|  |....   .|      |..
arvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgiv
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 32-205 4.8e-41 133.9 In-house 3-192 (302) alignment 
Range on Protein: 32-205
Range on HMM: 3-192/302.0
KMMVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHP-----------PKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYP
|    .|....|...  . |  |  | .. .|| ..||||||..||.| . .  .             ......||||||||. |.| ..|..|.|| ||
kkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyp

TSIHLLRGNHESAAINRYYGFYDECKRRFT----IRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPA-EVDRNGL
|   |||||||. |||  ||| .| . |..     ..|. | ...  .|.||.. .||.  |||.|| |. |.||....||  ||  . |
tnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedsl
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 32-205 6.5e-41 133.5 In-house 4-193 (302) alignment 
Range on Protein: 32-205
Range on HMM: 4-193/302.0
KMMVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHP-----------PKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYP
|    .|....|...  . |  |  | .. .|| ..||||||..||.| . .  .             ......||||||||. |.| ..|..|.|| ||
kkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyp

TSIHLLRGNHESAAINRYYGFYDECKRRFT----IRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDIQHLQRPA-EVDRNGL
|   |||||||. |||  ||| .| . |..     ..|. | ...  .|.||.. .||.  |||.|| |. |.||....||  ||  . |
tnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedsl
subfamily_PPPLV_pd Subfamily PPPLV 43-190 3.7e-36 117.9 In-house 5-159 (290) alignment 
Range on Protein: 43-190
Range on HMM: 5-159/290.0
LLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLrYFET-----SGHPPKKRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAINR
| ..| ..|..|  || ...|. ||||.||.|.||  |||              .|.||||||||..||| .. ||| || ||. ..|||||||  ..  
lcdvavdilaaeerllelksptyvlgdlhgnyrdli.yfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

YYGFYDECKRRFTIRL---WRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLND
 . .. |.. .|  .|   |  | ...| ||.||.|. |.| .|.|.  . .    
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqay
subfamily_PPP7C_pd Subfamily PPP7C 32-196 6.7e-36 116.8 In-house 30-201 (383) alignment 
Range on Protein: 32-196
Range on HMM: 30-201/383.0
KMMVPESDIIKLLKQARQVLMSEPMLLTVEA----PVNVLGDIHGQYNDLLRYFETSGHPPK-KRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLL
| ..    ....|..|..|| . | .  |..     | | ||.||. .|||  .   | | . . |.. ||.||||| ||| | .|||. . ||....| 
kkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevyln

RGNHESAAINRYYGFYDECKRRF---TIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSlHNLNDIQHLQR
|||||   .|  |||  | . ..   . .. |.. | .  ||.|..|..||. .|||.| .  .|. .....|
rGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdk.tdlelldkier
Metallophos Calcineurin-like phosphoesterase 63-191 1.3e-34 113.2 Pfam-A 2-170 (200) alignment 
Range on Protein: 63-191
Range on HMM: 2-170/200.0
PVNVLGDIHGQYNDL----LRYFETSGHPPKKRYLMLGDYVDRGKYSVETLTLL--LAYKVRYPTSIHLLRGNHESAAINRYYGFYDECK----------
.. |.||.||...||    |....  ....   .| |||.||||..| ||| ||  |..|...|. ..||||||||  .| .|||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------RRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLNDI
                         . . . .... .....|| .|... ||. .||.||.|. . .||
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 90-209 3e-34 111.6 In-house 120-239 (339) alignment 
Range on Protein: 90-209
Range on HMM: 120-239/339.0
KRYLMLGDYVDRGKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAINRYYGFYDECKRRFTIRLWRMFVDCYDCLPVAAIINSKIFWCHGGLSPSLHNLN
||||.|||||||| .|.| . || | |. ||  |.|||||||| ..|  |||| | . |.  .|.  | . .. .|..|.||  |.  |||.|  |  .|
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

DIQHLQRPAEVDRNGLLCDL
..  ..|| |.   |.| ||
qfsvfkrpleipdvgvltdl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 33-87 1e-14 47.4 In-house 7-61 (317) alignment 
Range on Protein: 33-87
Range on HMM: 7-61/317.0
MMVPESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHP
 .. |...|.|  .||... .||. | .|||| ..||||||..|||  ..  |.|
dlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 37-87 5.2e-12 38.5 In-house 13-63 (339) alignment 
Range on Protein: 37-87
Range on HMM: 13-63/339.0
ESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHP
 ... .| ..||... |||..| .|||. |.||||||..|||  ..  | |
aaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwp
subfamily_YNL217W_pd Subfamily YNL217W 65-183 5.5e-08 25.6 In-house 13-138 (235) alignment 
Range on Protein: 65-183
Range on HMM: 13-138/235.0
NVLGDIHGQYNDLLRYFE--TSGHPPKKRYLMLGDYVDRGKYSVETLTLLlaykvrYPTSIHLLRGNHESAAINRY------YGFYDE--CKRRFTI--R
 | ||.|| |..|.. ..  . |. .    ...|| ...|  |||.. ..        .  . ..|||| ... .|       |. .    ..  ..  .
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsflesk

LWRMFVDCYDCLPVA-AIINSKIFWCHGGLSP
| .  .. .  |. .  |   ...  |.||.|
lskadmeyarelgfsldipsdellvvhaGlvp