Gene PpD5 in Drosophila melanogaster

Synonym: 96A, CG6593, DmPp1-96A, Dmel\CG6593, PP1, PP1 96A, PP1 alpha96a, PP1alpha96A, PP1alpha[[1]], PP1c, PP1c 96A, Pp1-96A, pp1alpha96A, Dmel_CG6593, Pp1alpha-96A

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP092_AA protein Get Run
DmelP092_AA_25-316 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP1C_pd Subfamily PPP1C 40-314 9.3e-145 474.1 In-house 5-279 (282) alignment 
Range on Protein: 40-314
Range on HMM: 5-279/282.0
RRAGNLSEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGN
... .|.||.|.......||..||||.||||.|||||.||.|||..||||.|...|.|| |||||||||||||. |.||. |||.||..|||..||||||
gkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGn

HESADLNRVYGFFDECKRRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLLWSDPDETTGTWASNDRGVS
||||..||.|||.||||||||||||..|.|...|.|.||.....|.||||||||.|..|..||...||..||..||||||||||||... .|..||||||
hesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvs

FTFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVIIRPR
||||...|| ||......|||||||||||||||||.|||||.|||||||. |||.|||| ||..|...| |..|.
ftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpa
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 27-314 9.4e-124 405.3 In-house 6-294 (298) alignment 
Range on Protein: 27-314
Range on HMM: 6-294/298.0
VIIGQLKTMAVGNRRAGNLSEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYK
..| .|..   ... .  ..|. .. ... ....| .|..|.|. ||.|.|||.|||. ||||.|...| || .||||||||||||. ..|.. |||.||
llievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllayk

LRYPETFFLLRGNHESADLNRVYGFFDECKRRY-SIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLLWSDPD
..||. ||||||||| . .||||||..|||||| |..|. .| | .. .|..|.|..||.|.|||||. |..||..|.|.||.| ... |  ||||.||.
vkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpe

ETTGTWASNDRGVSFTFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVIIRPR
...  ||.| ||||..||.. |. .| . . .|.||||||| |||||||...||||||||.||. |||. ||. ||.|||. |....|.
navkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpe
subfamily_PPZ_pd Subfamily PPZ 26-313 1.2e-121 398.9 In-house 4-293 (300) alignment 
Range on Protein: 26-313
Range on HMM: 4-293/300.0
DVIIGQLKTMAVGNRRAGN--LSEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLL
| || .|       .|. |  | .. |  ||. .|||||.|| ||||| .||| ||.|||. ||||.| .||.|| .||||||||||||. |.||. |||
deiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillll

TYKLRYPETFFLLRGNHESADLNRVYGFFDECKRRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLLWSD
 ||..||| ||||||||| |.. |||||.||||||  ||.|..||| .. .|.|||.| .|||||||||| ||..|.||.. ||||||  ||. ||||||
cykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsd

PDETTGTWASNDRGVSFTFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVIIRP
| ...  |  |.||||. .    .. || .  |.|..||| ||||||||| || |||.|||||||  ||| |||. |   |.| | .. |
ptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 36-315 2.7e-113 371.2 In-house 15-295 (299) alignment 
Range on Protein: 36-315
Range on HMM: 15-295/299.0
AVGNRRAGNLSEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFL
  ..| . .. |  .  .|. ... |.||. |||. ||...|||.|||. ||||||.. | || .|.||||||||||   .|...||| .|..||| ||.
msekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffm

LRGNHESADLNRVYGFFDECKRRY-SIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLLWSDPDETTGTWASN
||||||   .||||||..||..|| | .||  | |... ||.. .|. ||.|.|||||| |..|| .| |.|| | |.  |  ||||.|||..   | .|
lrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlan

DRGVSFTFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVIIRPRP
 ||||. || ..|.  . . . .|. ||||||.|||||||...|||||||| ||  |||  |.. || .||| ||...| |
vrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptp
0045823 Metallo-dependent phosphatases 26-316 4.9e-112 367.9 In-house 31-326 (473) alignment 
Range on Protein: 26-316
Range on HMM: 31-326/473.0
DVIIGQLktmavgnRRAGNLSEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTY
|..| .|       .. | |.| .......  .|.. ..|.|||||... ..||.|||. ||||.....| ||  ...||||.||||. |.|.| ||| .
dlliehl.......kkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllal

KLRYPETFFLLRGNHESADLNRVYGFFDECKRRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLLWSDPD
|..||. .||||||||.. || .|||.||. ..|...|.. |... ...|.||.| ..|..|||||||||..||.||...|| ..|.||||.|||||||.
kikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPw

ETTGT-------WASNDRGVSFTFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQ------LVTIFSAPNYCDIFDNCGAVLVVDAKLvCHFVIIR
|. |.       .  . ||....||...|| || .....||||.|..|..|||.. |..      ..|.|||||||. ..|..||||.| .| ..|....
eddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfd

PRPF
| | 
psph
PP2Ac_SM00156 46-313 7.3e-111 362.5 In-house 2-269 (271) alignment 
Range on Protein: 46-313
Range on HMM: 2-269/271.0
SEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHESADL
|.  .  ......|.. ....|.|.|||| ..||.|||..||||.... |.|| ..|.|||||||||. |||...||...|..|||...|||||||| ..
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NRVYGFFDECKRRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLLWSDPDETTGTWASNDRGVSFTFGAN
|..|||..|.||.|. ...  | ......|.||.. ..|.|.||||||.|..|||||.|.|. . | .|||.|||||||.... ... . ||.|..||..
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

IVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVIIRP
.|. || .....||.|||.||..|||||||..|||||||||||| |.| .||| |. .| .... ...
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 46-314 2.2e-109 357.9 In-house 7-275 (280) alignment 
Range on Protein: 46-314
Range on HMM: 7-275/280.0
SEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHESADL
 || |  . .  ..... |  ..|. |||..|||||||. ||||.|.... || .||||||||||||.  .| . |||.||.|||..|..|||||| ...
keadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisi

NRVYGFFDECKRRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLLWSDPDETTGTWASNDRGVSFTFGAN
|| ||| ||.||||| .|.  | . .| .|..|... ||.|.|||||..|  |||...| || | . . |  ||||.||.. .  || | ||||  ||||
nrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifgan

IVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVIIRPR
.|  .  . . .||.| ||||.||||||||..|||.||||.|.. |||  |||.||..|.  | ...| 
vvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
0049330 Metallo-dependent phosphatases 26-316 1e-108 356.0 In-house 11-301 (309) alignment 
Range on Protein: 26-316
Range on HMM: 11-301/309.0
DVIIGQLKTMAVGNRRAGNLSEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTY
..|.. |. .    .. . ||| .. ....  .|...|.|.|||||... ..||.|||. ||||.....|.||  ...||||.||||. |.|.| ||| .
elilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllal

KLRYPETFFLLRGNHESADLNRVYGFFDECKRRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLLWSDPD
||.||. .||||||||.. ||..|||.||..|.|...||. |.|.....|.||.| ..|.||||||||||..||.||.|.||...| ||||||||||||.
kllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdpl

ETTGTWASNDRGVSFTFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVIIRPRPF
... ..| |.||....||...||.|| .....||.|.|..|..||..|.|..|.|.|||||||. ..|.||||..| .||..|....| |.
piregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpl
PPP_3 45-311 1.7e-105 344.9 In-house 2-269 (271) alignment 
Range on Protein: 45-311
Range on HMM: 2-269/271.0
LSEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHESAD
||| ... ...  .|.. ....|.|.||||..|||.|||..|||..|...| .| ..|||||||||||. |.|.| |||..|..||....||||||||..
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

LNRVYGFFDECK-RRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLLWSDPDETTGTWASNDRGVSFTFG
.|.|||| .|.. .... |... . ......|.||.| .....|||||||....||.|..|.|...||..|.|.|||.|...|.........||....||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

ANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVII
....| || ..|..||.|||...|.|||...|...||.|||||||. ..| ||.| ....| ..|...
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 45-313 3.4e-105 344.6 In-house 8-282 (284) alignment 
Range on Protein: 45-313
Range on HMM: 8-282/284.0
LSEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVP------PLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRG
|.|  .  .|  .||||  ... ||. |||||.||.||||.||| ...  | |        ..|||||||||||  ||| ..||..|||..|.  |||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHESADLNRVYGFFDECKRRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLLWSDPDETTGTWASNDRGV
||||  .|. |||. |||.||| .|. .|  .. .||..|.....|.|.|||.| || .|... .|.||.|.|  |...|| |.||...  ...  .|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SFTFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVIIRP
  .|||. |. || ..|..|.||||||| |||||||||.|||||||| ||  .|| .||| || .||. |....|
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
PPP_1 46-298 3e-103 337.7 In-house 2-262 (264) alignment 
Range on Protein: 46-298
Range on HMM: 2-262/264.0
SEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHESADL
.|.... ... ..||. ....|||.|.....|||.||||.|||..|...| .| .||||||||||||. |.|.| |||..||.||...|||||||||. .
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

NRVYGFFDECK-RRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLL-------WSDPDETTGTWASNDRG
..|||| .|.. ..|| .... ..|..|..|.||.| ..|..|||||||.|. ||.||...| |.||..| |||||       .||..|.....|...||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VSFTFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVL
....||....| || .....||.|||.|.|.||||...|..||||||.||.. ..| ||..
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayv
0053225 Metallo-dependent phosphatases 41-315 1.1e-99 326.5 In-house 18-292 (293) alignment 
Range on Protein: 41-315
Range on HMM: 18-292/293.0
RAGNLSEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNH
.   ||| .. ....  .|.....|.|||||... ..||.||.. |||......| || ....||||.||||. |.|.| ||| .||.||. ..||||||
llkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNH

ESADLNRVYGFFDECKRRY-SIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLLWSDPDETTGtWASNDRGVS
|.. || .|||.||..|.| . .||. ..|.....|.||.| ..|..|||||||||..||.||..|||...| .|||.||||||||. .| |. . ||..
ElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsg.wlpsyrglg

FTFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVIIRPRP
..||...|. || .....||.|.|||| |||... |..|||.||||||.. ..|.||||..| .||..|....|..
vvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPP4C_pd Subfamily PPP4C 40-311 4e-98 321.2 In-house 11-282 (288) alignment 
Range on Protein: 40-311
Range on HMM: 11-282/288.0
RRAGNLSEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGN
||.  ..| ... .|. .||... .  . .. .|| .|||.||||.|||..|.  |  |  |||||||.||||. |.||. |||..|.|||.   |.|||
rrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgn

HESADLNRVYGFFDECKRRY-SIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLLWSDPDETTgTWASNDRGV
||| .. .||||.||| |.| |...||  .. .| ...|||| ..||||||||||....||.|| ..| ..|| .| |||||||||.... .||   || 
hesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae.gwavsprga

SFTFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVII
 . ||...|| |  . ...||.||||.| .|| .  .....|..||||||    |  |.| .|..|  .| |.
gylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkif
subfamily_PPP2C_pd Subfamily PPP2C 41-314 6.5e-98 320.5 In-house 13-286 (290) alignment 
Range on Protein: 41-314
Range on HMM: 13-286/290.0
RAGNLSEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNH
.. .|.|...  .|.  .|.. ..  . |...|| .|||.||||.||| .|.  |  | .||||||||||||. |.||..|| . |.||.|   .|||||
eckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnh

ESADLNRVYGFFDECKRRYS-IKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLLWSDPDETTGtWASNDRGVS
|| .. .||||.||| |.|.  ..|. | | .|..|..|.. ..|||.|||||| .. ||.|| |.|  .|| .| ||||||||||. .| |.  .||  
esrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrgg.wgisprgag

FTFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVIIRPR
.||| .| | |  . ...||.||||.| .||..  ||..||||||||||    | .|.| .| ||  .|.   | 
ytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpa
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 57-314 7.7e-98 320.4 In-house 15-274 (284) alignment 
Range on Protein: 57-314
Range on HMM: 15-274/284.0
SRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHESADLNRVYGFFDECK
. ..|  ||||.|  .|..||||.|||| ||||.|.. |.|  .||||||||||||.  .||. ||..||. .|. ||.|||||| . .|..|||..||.
afsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeecq

RRYSI-KLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSD-GLLCDLLWSDPDETTGTWASNDRGVSFTFGANIVEGFLMQH
|||    .. ||   .  ||..|.. .||.|.|||.|  |.|. ..| ..|| | |    |  |.||||| .    |  | ||||. ||.. .  .| . 
rrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsdalrklldrl

KFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVIIRPR
. .|.|||||||.|||||||.|.|||||||| ||  |||. ||. |. .||| ||..|||
qidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrpr
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 45-313 4.4e-94 308.1 In-house 23-294 (297) alignment 
Range on Protein: 45-313
Range on HMM: 23-294/297.0
LSEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHESAD
..|  .  . . . ..| .|  ..|. ||.|.|||.|||| ||||.|.. | || .||||||||||||. ||||. |||.||...|  .||||||||   
iteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecef

LNRVYGFFDECKRRY-SIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSP---DLNNLDDIRRLNRPTDVpSDGLLCDLLWSDPDETTGTWASNDRGVSF
.|.||||..||..|| |.... .| | .. .|.. .||..|.|.||||||   .   || .|...|.|.   ..|..||||.||      .  |.||   
vnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqrgagc

TFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVIIRP
 || . |     . |..|..||||||.||||||| |.|||||||| ||  |||| |.. .| || | | |.||
gfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrp
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 50-315 1.4e-92 302.9 In-house 13-278 (281) alignment 
Range on Protein: 50-315
Range on HMM: 13-278/281.0
ITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHESADLNRVY
|  . .  . .| ..  | |. .|... ||||.||.|| |.|.  | .|   ..|||||||||  |.|.| ||.|.|.||..  .||||||| | .|..|
ienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiy

GFFDECKRRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLLWSDPDETTGTWASNDRGVSFTFGANIVEG
||. ||. .| ..||  |  |.. .|..| || |. |.||||||.| .||..|   .| . .  ||. ||||.|||. .  | .  ||.||||| |.|. 
gfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknvvdd

FLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVIIRPRP
   . . .||.|||||| |||| .. |.|.|.||.||||. . |..||| ||..|  ..| . | .
vckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpas
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 100-314 3.5e-91 298.7 In-house 101-315 (317) alignment 
Range on Protein: 100-314
Range on HMM: 101-315/317.0
SNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHESADLNRVYGFFDECKRRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLD
..|||||||||||  ||| ..||...||.||.  |||||||||  .|. |||. |.|.||| .|. .|   . ..|..|.....|.|.|||.| .| .|.
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

DIRRLNRPTDVPSDGLLCDLLWSDPDETTGTWASNDRGVSFTFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLV
 . .|.||.|.|  |.|.|| |.|||..  ...   || .. |||. |. || .....|.|||||||||||||||||.||||||||.||  .|| .||| 
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDAKLVCHFVIIRPR
|| ||.. . ..|| 
vdkklkisinvlrpe
subfamily_PPP6C_pd Subfamily PPP6C 43-304 2.5e-90 295.5 In-house 13-274 (290) alignment 
Range on Protein: 43-304
Range on HMM: 13-274/290.0
GNLSEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHES
  |.|. .  .|.   .|.| .  .  .|.|| .|||.|||| ||. .|.. |  | ..|.||||.||||. |.||...||| |..||.   ||||||||
kylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhes

ADLNRVYGFFDECKRRYS-IKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLLWSDPDETtGTWASNDRGVSFT
  . .||||.|||...|   . |. ... .| ...|||| ....|||||||||.. ||.|| ..| ...| .| .|||.||||..   |||  .||  . 
rqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedv.etwavsprgagyl

FGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKL
||..... |..  ...||.||||.||.|.... | .|||..||||||    |  ..| .. . 
fgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledae
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 45-316 1.1e-89 293.2 In-house 10-284 (287) alignment 
Range on Protein: 45-316
Range on HMM: 10-284/287.0
LSEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHESAD
.|.  |  . .  .|..   | |||. ||..|.||.|||..||||||...| .|  .|||||||||||  |.|   ||...|..||.   |||||||   
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

LNRVYGFFDECKRRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVP--SDGLLCDLLWSDPDETTGTWASND-RGVSFT
.|..||| .| ||... .|.. | | .. .|. |... ||.|.|||.||.|. ||... |..||      .||  ||||.||.. . | . |  |..|  
inklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvv

FGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVIIRPRPF
|| . |. .| . . .||||||.|.|.||.|..|..|||.|||| |.    |.|||.||.  |   || ..|  |
fGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedf
subfamily_PPP3C_pd Subfamily PPP3C 40-302 5.5e-86 282.1 In-house 36-311 (452) alignment 
Range on Protein: 40-302
Range on HMM: 36-311/452.0
RRAGNLSEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGN
 . |.|.|...  | . . .|. ... |||..||. ..||.|||| |||..|.  | |  ..|||||||||||  |||..  |.. |. ||.|.||||||
lkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGn

HESADLNRVYGFFDECKRRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLLWSDPDETTGTWA------S
||.  |   . | .||| .|| ... ......|..|.||.. .. .||||||||....||||..|.|  ..|. |.||||||||| |  |  .       
hecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvp

N-DRGVSFTFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFAD------RQLVTIFSAPNYCDIFDNCGAVLVVDA
|  || |. .. . |  || . ..  |.|||.. ..||. . .        |.|.||||||.|...| .||| .. 
nsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen
subfamily_PPG1_pd Subfamily PPG1 42-311 3.3e-85 279.0 In-house 11-293 (300) alignment 
Range on Protein: 42-311
Range on HMM: 11-293/300.0
AGNLSEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHE
|  | |.|.  ...  .||....  . |. .|| . ||.|||| |.| ||.  |  | .||||||||||||. |.||.|||.. |||||    |||||||
aellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhe

SADLNRVYGFFDECKRRY--SIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLLWSDPD----------ETTG
| .. .||||. || |.|    ..|. . . .| . .|||| . |.||||||||.   .|.|. |.|  .|| .| |.|||||||.          .  |
srqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdreg

-TWASNDRGVSFTFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVII
  .   .||  ...| ..|| || . ..| |.||||.. .||. . | .| |..||||||    |  ..| .  |.  .| . 
qhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvy
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 50-316 8.9e-83 271.0 In-house 11-277 (280) alignment 
Range on Protein: 50-316
Range on HMM: 11-277/280.0
ITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHESADLNRVY
|  | .    .|. .  | |  ||.|. ||.| |..|. |.|.  |  |  . .|||||||||   || | ||.  |.|| .  .|||||||.  .|..|
iiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiy

GFFDECKRRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLLWSDPDETTGTWASNDRGVSFTFGANIVEG
||. ||. .| . ||  |  |.. ||....|. |..|.||||||.| ||| || . || .    ||| ||||||| .    |  . ||.|. ||  .|| 
gfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveq

FLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVIIRPRPF
     . .||.||||||.||||..| |.|.|.|| ||||  | |. ||....|.|   |  . | |.
acksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipppl
subfamily_PPP5C_pd Subfamily PPP5C 32-301 2.2e-81 266.4 In-house 21-295 (322) alignment 
Range on Protein: 32-301
Range on HMM: 21-295/322.0
LKTMAVGNRRAGNLSEATITYICQASRELFLSQPMLLELSAP----VKICGDLHGQFKDLLRIFQQCGVPPLS-NYLFLGDYVDRGHCSIETLSLLLTYK
.| .    .   .| .  .. | . ..||. ..| |.|.. .    . .|||.|||| ||| ||.  |.|  .  ||| ||.||||  |.|.. .||..|
vkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfk

LRYPETFFLLRGNHESADLNRVYGFFDECKRRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGL-SPDLNNLDDIRRLNRPTDVPSDGLLCDLLWSDPD
| ||. ||| |||||| ..|..||| .|.| .|. |.   | . .. .|.| .| .... ||||| | |  .|||.|...| .. |..|||..||||||.
llyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpq

ETTGTWASNdRGVSFTFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVD
|..|...|. |||...|| .. . || . ...||.|.|.| |.|||.  | .|.|.||||||||  .| ||.. . 
eanGrspsk.rGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlr
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 45-314 7.1e-77 251.2 In-house 16-289 (290) alignment 
Range on Protein: 45-314
Range on HMM: 16-289/290.0
LSEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHESAD
.|.  |  | .  .|..   | |||. ||. | ||.|||...||| |.. | ||  ..||||||||||  |.|   ||. ||.||...  |||||||   
fsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrk

LNRVYGFFDECKRRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTD--VPSDGLLCDLLWSDPDE-TTGTWASN-DRGVSF
.||.||| .|  |. . .||. . | .. ... | .. .|.|.|||.|....  . .. |..|       .||  ||||.||..  . | | |  |..| 
vnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisv

TFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVIIRPR
 || . .. .| .  ..||||||.| |.|..|  |..|||.|||| |.    |.||.. |   |  ..|...||
vfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
PPP_2 74-265 1.3e-74 243.1 In-house 1-197 (198) alignment 
Range on Protein: 74-265
Range on HMM: 1-197/198.0
VKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHESADLNRVYGFFDECK-RRYSIKLWRSFVDCYD
|..|||||||..|||..|.... .| ..|||||||||||. |.|.| |||..||.||....||||||||...|.|||| .|.. .... |... . ....
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

CMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLL----WSDPDETTGTWASNDRGVSFTFGANIVEGFLMQHKFNLIVRAHQV
..|.||.| .....||||||.....||.|.. .|....|..|.|.|||    .|||.|.....|.. ||....||....| .| ..|..||.|||.|
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 56-313 1.6e-74 243.9 In-house 31-291 (307) alignment 
Range on Protein: 56-313
Range on HMM: 31-291/307.0
ASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHESADLNRVYGFFDEC
 .. .| |.  |...  |. . |||||||.||. .|   | || . |.| |||||||  |.|.. ||.|||. |||   ||||||| | .|. |||..||
eaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeec

KR---RYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVPSDGLLCDLLWSDPDETTGTWASNDRGVSFTFGANIVEGFLM
     .   ..|  |  |.. .|..|.|| .|.|.|||||| |  ||..|   .|   |  |.. |.||.||| .   | .  ||  ||||.|...    
vtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvck

QHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVIIRP
.   .||.||||.. |||  .. |.|.|||||| ||... |.|.|| ||  |  . | . |
rlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvp
PPP_4 74-265 1.1e-72 237.2 In-house 1-196 (197) alignment 
Range on Protein: 74-265
Range on HMM: 1-196/197.0
VKICGDLHGQFKDLLRIFQQCG-VPP-LSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHESADLNRVYGFFDECKRRYSIKLWRSFVDCY
| ..||.|||..||| .. ..|  |.  ..|.|||||||||. |.|.| ||| .||.||....||||||||..||..||| .|...... .... . |..
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

DCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVP-SDGLLCDL-LWSDPD-ETTGtWASNDRGVSFTFGANIVEGFLMQHKFNLIVRAHQV
|..|.||.|......||||||..|..||.|.|..|....| ......|| |||||  ...| .|.. ||....||....| || .....||.|.|..
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeg.lansvrGagllFgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 67-316 4.3e-72 235.9 In-house 2-258 (263) alignment 
Range on Protein: 67-316
Range on HMM: 2-258/263.0
LLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHESADLNRVYGFFDECKRRYSI-----
|||| ||..|||| |||..||||||. ||    ..|||||||||||  |.| . ||.. ||  |  ..|||||||   .|. |||. | |.|.       
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVP-SDGLLCDLLWSDPDETTGTWASN-DRGVSFTFGANIVEGFLMQHKFNLI
 ..  | . .  ||..||.. ||.|.|||.|| |..||||| .  | .   .  | |||||.||.. .  .  |  | .|  || . |. .  .   .||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

VRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFVIIRPRPF
|||||||| || |||||.|.|.|||  |   . |  ||.||.  |   || ..|  |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpedf
PPP_5_Dcr2 74-266 4.6e-69 225.4 In-house 1-199 (199) alignment 
Range on Protein: 74-266
Range on HMM: 1-199/199.0
VKICGDLHGQFKDL-LRIFQQCGVPP-LSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHESADLNRVYGFFDECKRR-YSIKLWRSFVDC
| .|||||||..|| |..|...| |.   .|.|||||||||. |.|.| ||| .||.||....|||||||. .||..||| .|.... .. |... . |.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

YDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRPTDVP-SDGLLCDL-LWSDPD-ETTGTWASNDRGVSFTFGANIVEGFLMQHKFNLIVRAHQVV
.|..|.||.|......|||||||............|....| ..|  .|| |||||  ...|..... ||....|| ...| || .....||.|.|...
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 40-303 1.8e-67 220.6 In-house 2-290 (302) alignment 
Range on Protein: 40-303
Range on HMM: 2-290/302.0
RRAGNLSEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCG---------VP--PLSNYLFLGDYVDRGHCSIETLSLLLTYKLR
.|  ..|.  .  ...|  ||.  .  | |.|.|| | ||.||||.||.||...           .     . ..|||||||||. ||| ..|....|. 
yrkkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvl

YPETFFLLRGNHESADLNRVYGFFDECKRRYS----IKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRP-TDVPSDGLLCDLLWSD
||. . |||||||.  .|  ||| .| . |..     ..|. | ...  ||.||.. ..|.|||||.|| |. |.||....|| ..| .| |  |||..|
yptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfad

PDETTG--------TWASN-DRGVSFTFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAK
| .. .         .| |  ||.|..|    |. .  . ...|||||||..  |. ||||..|.||||||.| .  || |||| ||..
pldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 43-303 1.8e-67 220.6 In-house 4-289 (302) alignment 
Range on Protein: 43-303
Range on HMM: 4-289/302.0
GNLSEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCG---------VP--PLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPE
 ..|.  .  ...|  ||.  .  | |.|.|| | ||.||||.||.||...           .     . ..|||||||||. ||| ..|....|. ||.
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlypt

TFFLLRGNHESADLNRVYGFFDECKRRYS----IKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNRP-TDVPSDGLLCDLLWSDPDE
 . |||||||.  .|  ||| .| . |..     ..|. | ...  ||.||.. ..|.|||||.|| |. |.||....|| ..|  | |  |||..|| .
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

TTG--------TWASN-DRGVSFTFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAK
. .         .| |  ||.|..|    |. .  .  ..|||||||..  |. ||||..|.||||||.| .  || |||| ||..
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 101-314 1.9e-67 220.8 In-house 121-334 (339) alignment 
Range on Protein: 101-314
Range on HMM: 121-334/339.0
NYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHESADLNRVYGFFDECKRRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDD
 |||||||||||  |.| . || . || ||.  .||||||||  .|  |||. | . ||  .|.  | . .. .|..|.| . |.|.|||.|  |  ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRRLNRPTDVPSDGLLCDLLWSDPDETTGTWASNDRGVSFTFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVV
.  ..|| ..|  |.| || |.||| |   .    || || ||   .  || .  .....| |||||||||||  |.|||||||||||   ||  ||. .
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DAKLVCHFVIIRPR
| ||     ..|| 
dkklkisinvfrpe
subfamily_PPPLV_pd Subfamily PPPLV 52-303 5.4e-52 169.9 In-house 4-278 (290) alignment 
Range on Protein: 52-303
Range on HMM: 4-278/290.0
YICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRI---FQQCGVP-PLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHESADLNR
 .|. . . ....  |||| .|. . |||||...||  .   . . ||    ...||||||||||. |.| .. ||. |. ||  ..|||||||   .  
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

VYGFFDECKRRYSIKL---WRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLN------NLDDIR-RLNrpTDVPSDGLLCDLLWSDPDETT---------
 . .  |.. ..  .|   | .| ...| .|.||.| ...||||.|.            ..||  ||.   |.    |  |.|||||.|           
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlk..ddidgaplaldilwsdpaedrdlslrgelv

--GTWASND-RGVSFTFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFdNCGAVLVVDAK
    ...|| || .  |... .| || .   . ..|||.| | |...  . .|.|.||. .||    |  |...|| |
lneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGss.neaalilvdkk
Metallophos Calcineurin-like phosphoesterase 73-265 2.3e-39 128.8 Pfam-A 2-198 (200) alignment 
Range on Protein: 73-265
Range on HMM: 2-198/200.0
PVKICGDLHGQFKDL----LRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLL--LTYKLRYPETFFLLRGNHESADLNRVYGFFDECK----------
.. ..|||||.. ||    |.... .. ..  ..|||||.||||  |.||| ||  | .||..|  .|||||||||  .| .|||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------RRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIrrlnrptdvpsdgllcdllwsdpdettgtwa
                         ..  . .. . ......| .|..  .|...||.||..... |||                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sndrgVSFTFGANIVEGFLMQHKFNLIVRAHQV
      |. || . .| .| ...  |..|.|. 
.....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 70-206 3.1e-37 121.2 In-house 62-201 (383) alignment 
Range on Protein: 70-206
Range on HMM: 62-201/383.0
LSAPVKICGDLHGQFKDLLRIFQQCGVPPLSN-YLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHESADLNRVYGFFDECKRRY---SIKLWR
.|  | .||||||...||| |. . |.|  .| |.| ||.||||. |.| | .||.. | ||. ..| |||||   ||  |||  | . .|   . |. |
iskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilr

SFVDCYDCMPVAAIIADRIFCVHGGLSpDLNNLDDIRRLNR
 . | .  .|.|..| ..|. ||||.| |  .|. . ...|
lledvfawlplatlidekilivhGGis.dktdlelldkier
subfamily_PPP7C_pd Subfamily PPP7C 217-309 1e-22 73.4 In-house 238-330 (383) alignment 
Range on Protein: 217-309
Range on HMM: 238-330/383.0
CDLLWSDPDETTGTWASNDRGVSFTFGANIVEGFLMQHKFNLIVRAHQVVEDGYEFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFV
 |.||||| ...| ..   ||    ||... . .| .....|..|.|.   .||||  |....||||| || ..  | || . .  .|  ..|
ldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpriv
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 45-97 9.8e-15 47.5 In-house 9-61 (317) alignment 
Range on Protein: 45-97
Range on HMM: 9-61/317.0
LSEATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVP
..|. .. .|  .|||| ..|. ||| |||.|.||.||||.||| ...  | |
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 47-97 8.6e-11 34.5 In-house 13-63 (339) alignment 
Range on Protein: 47-97
Range on HMM: 13-63/339.0
EATITYICQASRELFLSQPMLLELSAPVKICGDLHGQFKDLLRIFQQCGVP
 | .. .|. .|||  |.|..|.| ||. . ||.|||| ||| ...  | |
aaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwp
DUF316 Domain of unknown function (DUF316) 26-75 7.5e-06 11.8 Pfam-A 124-173 (282) alignment 
Range on Protein: 26-75
Range on HMM: 124-173/282.0
DViiGQLKTMAVGNRRAGNLSEATITYIC--QASRELFLSQPMLLELSAPVK
..   .|. . . . .  ... |..  ||    | .   ..|||.|| .| .
ei..eelskkkgkrskkakitrayvlniCknikskqklsakpmlvelekple