Gene PpD6 in Drosophila melanogaster

Synonym: CG10138, D5, Dmel\CG10138, anon-WO0140519.107, Dmel_CG10138, PpD5

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP093_AA protein Get Run
DmelP093_AA_48-321 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP1C_pd Subfamily PPP1C 47-320 1.8e-142 466.6 In-house 5-278 (282) alignment 
Range on Protein: 47-320
Range on HMM: 5-278/282.0
MQRLPLLESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGN
 ... | |.|.. |.. |||..|..|.||.. ||...|||||||..|||......|.||...||||||||||||.|.|||.||||...|.|....|||||
gkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGn

HESQSVNRVYGFFDECKRRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLLWSDPDRYGFGWTSSDRGVS
|||.|.||.|||.|||||||..||||||.|..||.|.||.....|.|.||||||.||.|..|..|.||.||||.||||||||||||.   ||...|||||
hesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvs

YLYGRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISFDIQRG
. .|.||.||||||||.||..||||||||||||||||||||||||||||| .||||| . ||..|..|| | . 
ftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkp
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 35-322 5.1e-118 386.4 In-house 6-295 (298) alignment 
Range on Protein: 35-322
Range on HMM: 6-295/298.0
LLNKLMSFRRSKMQ-RLPLLESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALR
|| ...|   |. .    . |..|. |..||...| . ..|..| |||.| ||||||. |||...|..|.||.. |||||||||||....|.|.|||| .
llievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllayk

VKFPKHIYLLRGNHESQSVNRVYGFFDECKRRY-TVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLLWSDPD
||.|....||||||| ...||||||..||||||  ..|...| | .| .|..|.|..||.| |||||..||.|... .. ||.. .|. |  ||||.||.
vkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpe

RYGFGWTSSDRGVSYLYGRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISFDIQRGDI
..  ||... ||||. .|.||....|.| | |||.|||||| |||||||...|||.||||.||| .||. | | ||..||.||.. .   
navkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
subfamily_PPZ_pd Subfamily PPZ 46-317 1.7e-113 372.1 In-house 19-290 (300) alignment 
Range on Protein: 46-317
Range on HMM: 19-290/300.0
KMQRLPLLESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRG
. . . | .||.  .|  |||||| .| ||..  ....|||.|||. |||... .||.||.. ||||||||||||.|.||| |||. ..|.|. ..||||
rtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrg

NHESQSVNRVYGFFDECKRRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLLWSDPDRYGFGWTSSDRGV
|||   | |||||.||||||  .|.|||||| .| .|.|||.. .||| |||||| |. . .|  ..|||.||. ||. |||||||      |   .|||
nhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergv

SYLYGRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISFDI
|| | .  ..|||.|  |||||||| |||||||||  | |||||||||||| .|| || | | . |. ||..
sycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfel
0045823 Metallo-dependent phosphatases 49-321 6.8e-111 364.1 In-house 40-324 (473) alignment 
Range on Protein: 49-321
Range on HMM: 40-324/473.0
RLPLLESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHE
   | |...  |.. |.|..  ||.||.....| |.||||||..|||..|...|.|| .|..||||.|||| .|.|.. ||||| .|.|....|||||||
egllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHE

SQSVNRVYGFFDECKRRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLLWSDPdRYGFG--------WTS
.  .| .|||.||. ..|...|.. |... ...|.||.| ..|...||||||.|. |. |..| || |.|. |||.|||||||    .|        .. 
lrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddgdgllrlrffgn

SDRGVSYLYGRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQ------LVTVFSAPNYCGLYDNAGASMGVDKDLvISFDIQRGD
| ||..||.|.|..|.||.||..||..|.|..|..|||.. ...      ..|||||||||| ..| .| . .|.|| ||| . . .
sprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdps
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 32-321 9e-110 359.6 In-house 3-294 (299) alignment 
Range on Protein: 32-321
Range on HMM: 3-294/299.0
LNDLLNKLMSFRRSKMQ-RLPLLESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLL
...|| ||..   |. .    . | |.  ||..|.. |.... ||.| |||.|.||||||. |||.|.|. |.||.. .||||||||||.. .|.|||||
vdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlll

ALRVKFPKHIYLLRGNHESQSVNRVYGFFDECKRRYT-VKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLLWS
. ..|.|.....||||||  ..||||||..||..||.  .||  | |... ||.. .|. ||.| ||||||.|..| ..  ..|| . |.  |  ||||.
cfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwa

DPDRYGFGWTSSDRGVSYLYGRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISFDIQRGD
|||..  .| .  |||||..|.||... ... | |||.||||||.|||||||...|||.|||| ||| .||. | | ||..|| .| . .  
dpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkpt
0049330 Metallo-dependent phosphatases 51-316 3.6e-107 350.9 In-house 29-294 (309) alignment 
Range on Protein: 51-316
Range on HMM: 29-294/309.0
PLLESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQ
 | |.|. ||.. |.|....||.||.....| |.||||||..|||..|...|.|| .|..||||.|||| .|.|...||||| ...|....|||||||. 
llseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvfllrGNHElr

SVNRVYGFFDECKRRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLLWSDPDRYGFGWTSSDRGVSYLYG
 .|..|||.||..|.| ..||. |.|.....|.||.| ..|.|.||||||.|. |..|... ||.|.|..|||||||||||...  |.. ..||.....|
llnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpiregfapnprglgvvfg

RDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISFD
 ...|.||.||..||..|.|..|..||..|....|.|||||||||| ..|.|| . .|.|||||| 
htaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfl
PP2Ac_SM00156 54-316 5.2e-107 349.9 In-house 3-265 (271) alignment 
Range on Protein: 54-316
Range on HMM: 3-265/271.0
ESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVN
..||  |.  ..|..  |..|..| ||. ||||||||..|||..|.. |.||...|.|||||||||..|.|.|.||.|| ...|....||||||||.|||
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn

RVYGFFDECKRRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLLWSDPDRYGFGWTSSDRGVSYLYGRDV
..|||..|.||.|. .... | ......|.||.....|.| ||||||.|..|..|... |. | || |||.|||||||..   |.. | ||.|...|.|.
kiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFgeda

LEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISFD
...||.||...|..|||.||..||||||...|||.|||||||. ..|..| . |.|.| .|. 
vkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsie
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 52-321 1e-103 339.7 In-house 8-283 (284) alignment 
Range on Protein: 52-321
Range on HMM: 8-283/284.0
LLESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYP------PQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRG
| | |.  ||  |||||  |.. |.. ||...|||||||| ||| .||  |.|       ...|||||||||||  |.| ||||.|.....|....||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHESQSVNRVYGFFDECKRRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLLWSDPDRYGFGWTSSDRGV
||||. ||. |||. |||.||...|...|  ..|.||..|..|..|.| |||.| .| .| ... . ||...|. |...|| |.||.   .|.. |.|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SYLYGRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISFDIQRGD
  ..| . ...||.| ..||| |||||| ||||||| |.|||.|||| ||| .||..| . ||..||.|| . . |
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkpd
PPP_3 54-316 2.6e-103 337.7 In-house 4-267 (271) alignment 
Range on Protein: 54-316
Range on HMM: 4-267/271.0
ESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVN
|.|.. |.. ..|..  |..|... ||. |.||||||..|||.. ...| .|.|.||||||||||||.|.|...||||| .|.||...||||||||...|
enelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqin

RVYGFFDECK-RRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLLWSDPDRYGFGWTSSDRGVSYLYGRD
.|||| .|.. .... |..|.. ......|.||.|.......||||||..|.|..|... |..||||.|.|.|||.|....   |...|.||...|.| |
kvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFgpd

VLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISFD
| |.||.||...|..|||...|.|||.......||||||||||. ..|||| . ....|  .| 
vteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefk
0053225 Metallo-dependent phosphatases 51-316 1.7e-100 329.1 In-house 21-286 (293) alignment 
Range on Protein: 51-316
Range on HMM: 21-286/293.0
PLLESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQ
 | |.|. ||...|.|... ||.||.....| |.|||||...|||..|...|.|| .|..||||.|||| .|.|...||||| ...|....|||||||. 
llseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNHElm

SVNRVYGFFDECKRRY-TVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLLWSDPDrYGFGWTSSDRGVSYLY
 .| .|||.||..|.|   .||. ..|.....|.||.| ..|...||||||.|  |..|..| ||...|..|||.|||||||| . .||. | ||.....
llnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.lwsgwlpsyrglgvvf

GRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISFD
| .....||.||..||..|.|||| |||... ...||||||||||.| ..|.|| . .|..||..| 
ghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfk
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 57-325 2.2e-100 328.4 In-house 11-279 (280) alignment 
Range on Protein: 57-325
Range on HMM: 11-279/280.0
VNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVNRVY
.. .    ..... .  ...| ||..|.||.|||. |||........||.. |||||||||||.  .| | |||| .|..|.....||||||  |.|| |
idrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrky

GFFDECKRRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLLWSDPDRYGFGWTSSDRGVSYLYGRDVLEK
|| ||.||||. .|.. | . .. .|..|..| ||.| |||||..|. |...  . || . ..  |  ||||.||.    ||. . ||||...| .|. .
gfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganvvkd

FLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISFDIQRGDIRRI
. .| | ||..| ||||.|||||||...||||||||.|.| .||. | . ||. |..||.. . ..| .
ltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpalrev
PPP_1 54-305 4.2e-100 327.4 In-house 3-262 (264) alignment 
Range on Protein: 54-305
Range on HMM: 3-262/264.0
ESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVN
|.|.  |.. ..||.  |..||.| ..| |.|||||||.||||.  ..| .|.|.||||||||||||.|||...||||| .|.||...||||||||..|.
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

RVYGFFDECK-RRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLL-------WSDPDRYGFGWTSSDRGV
.|||| .|.. ..|. ...||..|.....|.||.| ..|...||||||.|. | .|. . | |||||.| |||||       .||...   ....|.||.
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

SYLYGRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASM
.||.|.|| |||||||...|..|||.|.|.||||..||..||.|||.||.   .|.|| .
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayv
subfamily_PPP4C_pd Subfamily PPP4C 52-317 5.5e-99 324.0 In-house 16-281 (288) alignment 
Range on Protein: 52-317
Range on HMM: 16-281/288.0
LLESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQS
. |.||. ||. |||....|  . .| .|. | |||||||||||....  |  |.|.||||||.||||..||||. |||||.|..|..|.|.||||||..
ikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrq

VNRVYGFFDECKRRYT-VKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLLWSDPDRYGfGWTSSDRGVSYLYG
. .||||.||| |.|  ...|.  .. .. ...|||| ..||| ||||||....| .| || | .|||. | |||||||||.    ||. | ||  ||.|
itqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae.gwavsprgagylfg

RDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISFDI
 || |.| ..||..|.|||||.| .|| .  .....||.||||||    |  | . .|..|   | |
sdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfki
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 56-320 8.2e-98 320.3 In-house 7-273 (284) alignment 
Range on Protein: 56-320
Range on HMM: 7-273/284.0
EVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVNRV
.|. |   | ..|  .|||..| .|| ..||||||| |||...|. |.| .. ||||||||||||  .||| ||.| .| ||.|...||||||   .|..
dvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinki

YGFFDECKRRYTV-KLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETG-LLCDLLWSDPDRYGFGWTSSDRGVSYLYGRDV
|||..||.|||    ....|   .  ||..|.. .||.| |||.|  |...|.. .| || . ||   |  |.|||||  .  ||    |||||..| | 
ygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsda

LEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISFDIQRG
| |.|.. . ||| ||||||.|||||||.|.|||.|||| ||| .||| | | |.|.|| || . | 
lrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrp
subfamily_PPP2C_pd Subfamily PPP2C 51-316 4.7e-97 317.7 In-house 16-281 (290) alignment 
Range on Protein: 51-316
Range on HMM: 16-281/290.0
PLLESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQ
.| ||||. ||  |.|..  |  . .| .|. |.||.||||.|||...   |  |.| |||||||||||  ||||.||| ||.|.... | .|||||||.
qleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesr

SVNRVYGFFDECKRRYT-VKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLLWSDPDRYGfGWTSSDRGVSYLY
 . .||||.||| |.|.  ..|| | | ....|..|.. ..||| ||||||... | .|... |  |||. | ||||||||||  | ||. |.||  | .
qitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg.gwgisprgagytf

GRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISFD
|.|. ||| ..|.. |. ||||.| .||..  .|..||.|||||||    | .| . .|..|  || 
gkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysfl
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 54-315 3e-94 308.4 In-house 10-271 (281) alignment 
Range on Protein: 54-315
Range on HMM: 10-271/281.0
ESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVN
. |.. .   .. .| .|  | .. .|| ||||.|.|| || ....  | .|.....|||||||||..|.|.. ||..|.......|.|||||||  |||
keeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvn

RVYGFFDECKRRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLLWSDPDRYGFGWTSSDRGVSYLYGRDV
..|||. ||. .| ..||  |  |.| .|..| |..|. | ||||||.|  | ..  . .| . .. ||. ||||.|||  ...| .| ||.|...|..|
kiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknv

LEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISF
...  .. . .|. |||||| |||| .. |.|.||||.||||  | ||.| . ||..| ||.
vddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgisl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 106-321 1.2e-92 303.4 In-house 100-315 (317) alignment 
Range on Protein: 106-321
Range on HMM: 100-315/317.0
QTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVNRVYGFFDECKRRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKEL
. .|||||||||||  |.| ..||.||....|....||||||||..||. |||. |.|.|| ..|...|   .|..|..|.....|.| |||.| .| .|
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldl

SNIESIARPTEVPETGLLCDLLWSDPDRYGFGWTSSDRGVSYLYGRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASM
.... . ||...|. |.|.|| |.|||    |.  | || . ..| . ...||.| |.||| |||||||||||||| |.|||.||||.|||  ||..| .
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

GVDKDLVISFDIQRGD
 |||.|.||. . | .
svdkklkisinvlrpe
subfamily_PPP6C_pd Subfamily PPP6C 52-309 1.3e-90 296.4 In-house 15-272 (290) alignment 
Range on Protein: 52-309
Range on HMM: 15-272/290.0
LLESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQS
| |.... || |  .|.|.|  . .| .|. |.||||||||||.... . |  |.|.|.||||.||||  |.||.|.||.|..|.|..| ||||||||. 
lpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrq

VNRVYGFFDECKRRYT-VKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLLWSDPDRYGfGWTSSDRGVSYLYG
. .||||.|||...|  .. || ... .. ...|||| ....| ||||||..| | .|. | | .|.|. | .|||.||||.     |. |.||  ||.|
itqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedve.twavsprgagylfg

RDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDK
. | ..|.. |...|.|||||.||.|.... . .||||.||||||    |  . . ...
skvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaled
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 53-319 4.3e-90 295.0 In-house 24-293 (297) alignment 
Range on Protein: 53-319
Range on HMM: 24-293/297.0
LESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSV
 |  |  |  || ..|  .  ...| |||.|.||||||| |||... . |.|| . |||||||||||. |.||| |||| .||||  ..||||||| . |
teervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefv

NRVYGFFDECKRRY-TVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQ-LKE--LSNIESIARPTEVPEtGLLCDLLWSDPDRYGFGWTSSDRGVSYL
|.||||..||..|| .|... .| | .| .|.. .|. .|.| ||||||   ||  |  .  | |.||  | .|..||||.||     |.   .||    
nkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegke.rlvadllwadpisglsgfmenqrgagcg

YGRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISFDIQR
.||| . |   . ..||||||||||.||||||| |.|||.|||| ||| .||. | | .|. |  ||.| |
fgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilr
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 64-317 4.6e-88 287.9 In-house 22-278 (287) alignment 
Range on Protein: 64-317
Range on HMM: 22-278/287.0
ARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVNRVYGFFDECK
..|..   | ||.| ||| .|||||||. |||.|....|..|...||||||||||| .|.| . ||..|....||...||||||| . .|..||| .| |
ieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinklyGfkeelk

RRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPET--GLLCDLLWSDPDRYGFGWTS-SDRGVSYLYGRDVLEKFLQK
|..  .|.|.| | .. .|. |..|.||.| |||.||.|| | ..... .||   .   ||  ||||.||..   .      |..| ..|. .....|.|
rkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfGkkevddllkk

NDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISFDI
 | ||. |||.|.|.||.|.....|||||||| |.|   | || . |.| | .||  
ldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvv
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 61-316 8.4e-88 287.4 In-house 15-270 (280) alignment 
Range on Protein: 61-316
Range on HMM: 15-270/280.0
CTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVNRVYGFFD
  .   .|..|  | .  |||.|.|||| |. |. ...|  |  |. . .||||||||| . .| . ||..|....  .|||||||||. |||..|||. 
irmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyv

ECKRRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLLWSDPDRYGFGWTSSDRGVSYLYGRDVLEKFLQK
||. .| | ||  |  |.| ||....||.|..| ||||||.| .|  |  | || |  . ||| |||||||   | ||  | ||.||..|. |.|.  . 
ecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqacks

NDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISFD
 . ||. ||||||.||||..| |.|.|||| ||||  . || | . .. .| .||.
leidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfq
subfamily_PPP3C_pd Subfamily PPP3C 52-310 1.2e-86 284.3 In-house 41-312 (452) alignment 
Range on Protein: 52-310
Range on HMM: 41-312/452.0
LLESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQS
| |...  . . | .|. .|. ||.| ||| |.||||||||||||...  | | .|.|||||||||||  |.|..  |.||....|....|||||||.. 
leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrh

VNRVYGFFDECKRRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLLWSDP-DRYGFGW------TSSDRG
.   . | .||| .|. .............|.||.. .. .|.||||||..|.| .|... |  |.|..|.||||||||| ..||           | ||
lteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvrG

VSYLYGRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAK------RQLVTVFSAPNYCGLYDNAGASMGVDKD
 ||.|.     .||||||.  . |||.. ..||. . |        |.|.||||||.. |.| .| . ....
csyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn
subfamily_PPG1_pd Subfamily PPG1 47-311 1.3e-83 273.7 In-house 11-286 (300) alignment 
Range on Protein: 47-311
Range on HMM: 11-286/300.0
MQRLPllESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGN
 . ||  |. |. |.   .||...|  . .. .|. ||||.||||||.|.|..  |  |.| |||||||||||  |||||.||..|....|  | |||||
aellp..evtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgn

HESQSVNRVYGFFDECKRRY--TVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLLWSDPD-----------R
|||. . .||||. || |.|    ..|| . . .. . .|||| . |.| ||||||. . . .|  . |  |||. | |.|||||||.           |
hesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdr

YGFGWTSSDRGVSYLYGRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDL
 |  .. |.||  | ||.|| ||||..||.. . ||||.. .||. .   .| ||.||||||    |  . . . . .
egqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekd
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 64-319 2.2e-77 252.9 In-house 28-287 (290) alignment 
Range on Protein: 64-319
Range on HMM: 28-287/290.0
ARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVNRVYGFFDECK
..|..   | ||.| ||| .|||||||. .||. .|. ||||. ..|||||||||| .|.|   ||. ......|...||||||| . |||.||| .|  
ieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrlygfkeela

RRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTE--VPETGLLCDLLWSDPDR--YGFGWTSSDRGVSYLYGRDVLEKFLQ
|. . .||| . | .. ... | ....|.| |||.|....    .... .|      . ||  ||||.||.|           |..| ..|...|...|.
rkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvvfgkkglddllk

KNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISFDIQR
|  ..|. |||.| |.|..|  ...|||||||| |.|   | || . | . | .|. . .
klalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlk
subfamily_PPP5C_pd Subfamily PPP5C 64-314 4.9e-77 252.1 In-house 46-302 (322) alignment 
Range on Protein: 64-314
Range on HMM: 46-302/322.0
ARELFLDEPMLLNVPAP----IRVVGDIHGQFYDLLKILDQCGYPPQT-RYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVNRVYGF
|.||. ..| |...  .    . | ||||||||||| |..  |.| ..  ||| ||.||||  |||.| .||.... .|.|..| ||||||...|..|||
akellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGf

FDECKRRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSP-QLKELSNIESIARPTEVPETGLLCDLLWSDPDRYgFGWTSSDRGVSYLYGRDVLEKF
 .|.| .|| |. . | . .| .|.| .| .... .||||   .   |...  | | .. || |||..||||||..   | ..| |||.  .| || .||
egevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqea.nGrspskrGvgvqfGpdvtkkf

LQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGV-DKDLVIS
|..|...|. |.|.| |.|||.  . .|.|||||||||   .| || . . ..|| . 
lkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 107-323 5.8e-75 245.5 In-house 120-336 (339) alignment 
Range on Protein: 107-323
Range on HMM: 120-336/339.0
TRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVNRVYGFFDECKRRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELS
 ||||||||||||  |.| . || ||.. .| .||||||||||.|||  |||. | . ||  .|.. | . .| .|..|.|   |.| |||.| .|  . 
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

NIESIARPTEVPETGLLCDLLWSDPDRYGFGWTSSDRGVSYLYGRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMG
..  . || |.|. |.| || |.|||    |.  | || |...|   |  ||.| |...| | |||||||||||  |.|||.||||||||  ||. | . 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

VDKDLVISFDIQRGDIR
.|| | || .. | . |
idkklkisinvfrpesr
PPP_2 81-272 1e-74 243.5 In-house 1-197 (198) alignment 
Range on Protein: 81-272
Range on HMM: 1-197/198.0
IRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVNRVYGFFDECK-RRYTVKLWKTFVDCYN
..|.||.|||..|||.. .... .|...||||||||||||.|.|...||||| ...||...||||||||..||.|||| .|.. .... |..|.. ....
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

CMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLL----WSDPDRYGFGWTSSDRGVSYLYGRDVLEKFLQKNDFDLVCRAHQV
..|.||.|.......|||||...|.|..|... |..|.||.|.|.|||    .|||..   ....| ||...|.|.|| |..|.||...|..|||.|
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 81-272 8.4e-74 240.9 In-house 1-196 (197) alignment 
Range on Protein: 81-272
Range on HMM: 1-196/197.0
IRVVGDIHGQFYDL-LKILDQCGYPP-QTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVNRVYGFFDECKRRYTVKLWKTFVDCY
. ||||||||..|| ||.|.  | |. ...|.||||||||||.|.|...||||| ...||...||||||||.|.|..||| .|...... ...|.. |..
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

NCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVP-ETGLLCDL-LWSDPDRYGFGWTSSDRGVSYLYGRDVLEKFLQKNDFDLVCRAHQV
...|.||.|.......|||||..|..|..|| |.|..|.| | ....|| ||||| .   |...| ||...|.|.|| ||||.||...|..|.|..
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 81-273 4.8e-70 228.6 In-house 1-199 (199) alignment 
Range on Protein: 81-273
Range on HMM: 1-199/199.0
IRVVGDIHGQFYDL-LKILDQCGYPP-QTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVNRVYGFFDECKRR-YTVKLWKTFVDC
. |.||.|||..|| |......| |. ...|.||||||||||.|.|...||||| ...||...|||||||....|..||| .|.... .  |..|.. |.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

YNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVP-ETGLLCDL-LWSDPDRYGFG-WTSSDRGVSYLYGRDVLEKFLQKNDFDLVCRAHQVV
....|.||.|. .....||||||..|.....| |.|..|.| |.|  .|| ||||| .   | ...| ||...|.|.|| ||||.||...|..|.|...
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 48-314 1.2e-69 227.8 In-house 16-285 (307) alignment 
Range on Protein: 48-314
Range on HMM: 16-285/307.0
QRLPLLESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNH
...     |.. .   |. .|  |  |...  |  ||||.|||| ||....   | ||.| |.| |||||||  |.|.| ||.. .. .|..| ||||||
hkiqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnh

ESQSVNRVYGFFDECKR---RYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLLWSDPDRYGFGWTSSDRG
|   ||. |||..||     .   ..|  |  |.| .|..|.|. .|.| |||||| |  | ..    .|   |  |.. |.||.|||   | | .| ||
eiarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrg

VSYLYGRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVIS
  . .| .|..   ..   .|. ||||.. |||  .. |.|.|.|||| || .| |||. . ||. | | 
sgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiq
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 74-315 1.8e-69 227.3 In-house 2-250 (263) alignment 
Range on Protein: 74-315
Range on HMM: 2-250/263.0
LLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVNRVYGFFDECKRRYTV-----
||.. ||| ..|| |||. |||.|.. ||   .|.|||||||||||  |.| | ||..|.. .|....||||||| ...|. |||. | |.|.       
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPET-GLLCDLLWSDPDRYGFGWTSS-DRGVSYLYGRDVLEKFLQKNDFDLV
 ... | . .. ||..||.|.||.| |||.||.|| | .| .|  | |  .|  | |||||.||..   |.     | .| ..|.  .. . .. | ||.
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISF
 ||||||| || ||| |.|.|||||  |     |  | . |.| | .||
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsf
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 54-315 7.5e-65 212.1 In-house 8-294 (302) alignment 
Range on Protein: 54-315
Range on HMM: 8-294/302.0
ESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQ------------CGYpPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIY
.||. ||.    ||.  |  | .. .|. .|||||||| ||..|| .             ..  . ...|||||||||..|.| |.|..||.| .|..  
ksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlyptnyi

LLRGNHESQSVNRVYGFFDECKRRY----TVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARP-TEVPETGLLCDLLWSDPDRYGF
|||||||....|  ||| .| . |.    . ..|. | ...  ||.||.. ..|.| |||.||.|. | .|..| || .|| |  |  |||..||     
llrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvql

GWT---------SSDRGVSYLYGRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISF
  .            ||.|...    .... .. ...|. ||||..  |. |||...|.|.||||.|    || || . || .  .| 
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsi
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 53-315 1.1e-64 211.5 In-house 8-295 (302) alignment 
Range on Protein: 53-315
Range on HMM: 8-295/302.0
LESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQ------------CGYpPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHI
 .||. ||.    ||.  |  | .. .|. .|||||||| ||..|| .             ..  . ...|||||||||..|.| |.|..||.| .|.. 
sksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlyptny

YLLRGNHESQSVNRVYGFFDECKRRY----TVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARP-TEVPETGLLCDLLWSDPDRYG
 |||||||....|  ||| .| . |.    . ..|. | ...  ||.||.. ..|.| |||.||.|. | .|..| || .|| |  |  |||..||    
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

FGWT---------SSDRGVSYLYGRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDLVISF
   .            ||.|...    .... .. ...|. ||||..  |. |||...|.|.||||.|    || || . || .  .| 
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsi
subfamily_PPPLV_pd Subfamily PPPLV 60-309 4e-57 186.7 In-house 5-277 (290) alignment 
Range on Protein: 60-309
Range on HMM: 5-277/290.0
LCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQ---CGYP-PQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVNRV
||  | . ...|  ||.. .|. |.||.||.. ||  . ..    |     . .||||||||||. ||| |. ||||.| .| ...||||||| .||   
lcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqes

YGFFDECKRRYTVKL---WKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKE---LSNIESIAR--PTEVPETGLLCDLLWSDPDR-------------Y
. .  |.. ..  .|   |..| .... .|.||.| ...||.|.|.    .    .| |. |    . ..  . |  |.|||||.               
ieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlne

GFGWTsSDRGVSYLYGRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAgASMGVDK
||    . || ..... | ||.||..|. . | |||.| | |...  | .|.||||. .|||. ..| | . |||
Gfvdn.drrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssnea.alilvdk
Metallophos Calcineurin-like phosphoesterase 80-272 1.2e-42 139.4 Pfam-A 2-198 (200) alignment 
Range on Protein: 80-272
Range on HMM: 2-198/200.0
PIRVVGDIHGQFYDL----LKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLL--LALRVKFPKHIYLLRGNHESQSVNRVYGFFDECK----------
.| |.||.||...||    |..|. ..... . .|||||.||||..| ||. ||  |.| ...|....|||||||| ..| .|||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------RRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIesiarptevpetgllcdllwsdpdrygfgwt
                         ... . .  . ......| .|..  .|...||.||. ..    |                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

ssdrgVSYLYGRDVLEKFLQKNDFDLVCRAHQV
      |.|.|.|.|||.|.|.. |||.|.|. 
.....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 80-213 9.3e-37 119.6 In-house 65-201 (383) alignment 
Range on Protein: 80-213
Range on HMM: 65-201/383.0
PIRVVGDIHGQFYDLLKILDQCGYPPQ-TRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVNRVYGFFDECKRRY---TVKLWKTFV
 . | ||.||.. ||| || . |.| .   |.| ||.|||||.||| . .|||| . .||..|| ||||| . .|  |||  | . .|   . |. ... 
evtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlle

DCYNCMPVAAIISHRIFCCHGGLSPQlKELSNIESIAR
| .  .|.|..| ..|. .|||.| .  .|. ...|.|
dvfawlplatlidekilivhGGisdk.tdlelldkier
subfamily_PPP7C_pd Subfamily PPP7C 223-311 8.5e-19 60.5 In-house 237-325 (383) alignment 
Range on Protein: 223-311
Range on HMM: 237-325/383.0
LCDLLWSDPDRYGFGWTSSDRGVSYLYGRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLVTVFSAPNYCGLYDNAGASMGVDKDL
. |.|||||      .. . ||    .| || .|.||| ...|. |.|.   .||||  .....|.||| ||     | || . . |||
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 52-104 2.4e-15 49.5 In-house 9-61 (317) alignment 
Range on Protein: 52-104
Range on HMM: 9-61/317.0
LLESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYP
. |.|.  ||  |||||  ||. |.. ||. .|||||||| ||| .||  |.|
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 55-104 3e-13 42.6 In-house 14-63 (339) alignment 
Range on Protein: 55-104
Range on HMM: 14-63/339.0
SEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYP
.|.  ||  ||||   ||..|.. ||| |.||||||| ||| .||  |.|
aelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwp
subfamily_YNL217W_pd Subfamily YNL217W 82-201 2.1e-09 30.2 In-house 13-139 (235) alignment 
Range on Protein: 82-201
Range on HMM: 13-139/235.0
RVVGDIHGQFYDLLKILD--QCGYPPQTRYLFLGDYVDRGKNSVETITLLlalrvkFPKHIYLLRGNHESQSVN------RVYGFFDE--CKRRYTV--K
 ||||.|| . .|...||  . |  ..   ...|| ...| .|||.. ..        .. . ..||||   .       .  |. .    ..  ..  |
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsflesk

LWKTFVDCYNCMPVA-AIISHRIFCCHGGLSPQ
| |  .. .  .. .  | |. ..  |.||.|.
lskadmeyarelgfsldipsdellvvhaGlvpg
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 82-270 4.5e-07 22.0 Pfam-A 4-117 (156) alignment 
Range on Protein: 82-270
Range on HMM: 4-117/156.0
RVVGDIHGQFYDLLKILDQCgyPPQTRYLFLGDYVDRgknsVETITLLlalrVKFPkhIYLLRGNHESQSVNRVYGFFDeckrrytvklwktfvdcYNCM
 ...|.||.. .| ..|...       .|..||.|..     |.. ||     ..|  .. .||||. . ..  . .                   ..  
aiiSDlHgnldaleavledi..kevdlilhaGDlvep....eevvell....edip..vlavrGnhDeaelpkelavel.................llaa

PVAAIISHRIFCCHGGLSPqlkelsniesiarptevpetgllcdllwsdpdrygfgwtssdrgvsYLYGRDVLEKFLQKNDFDLVCRAH
 .  |   |.. .||   .                                                 ... |.. |.....|||. .|
aaleiegdrvllvhgtpls..............................................vqsseeelaellkeagadlvflGH