Gene PpN58A in Drosophila melanogaster

Synonym: CG8822, D6, Dmel\CG8822, PP1, Dmel_CG8822, PpD6

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP094_AA protein Get Run
DmelP094_AA_33-313 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP1C_pd Subfamily PPP1C 38-312 1.1e-144 473.9 In-house 5-279 (282) alignment 
Range on Protein: 38-312
Range on HMM: 5-279/282.0
GSVVQISVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGN
|. |... .||||....|||.||.||.|||. ||....||||||| .|||.||..|.||.| ||.|||||||||||.||..||||.| .||....|||||
gkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGn

HECSSINHFYGFYDECKRRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDILWSDPDLRIMGWGPNERGVS
||..|||..|||||||||||..|||.||.|..|||||||...|.|.|.||||||.| |..|||.|.||.|.||.||.||.|||||| ...||. |.||||
hesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvs

HTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFRVQRPI
.|||.|||..||....|.||.|.||||||||||||||||.|.|||||||||||||||.......||..|.. .| 
ftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpa
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 39-312 2.1e-121 397.6 In-house 20-294 (298) alignment 
Range on Protein: 39-312
Range on HMM: 20-294/298.0
SVVQISVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNH
 . .|. ...| ... |.... ||..|.|. |||.. ||||||| .||| |. .|.|||. ||.||||||||.|..|...|||| |..||..|.||||||
ltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnh

ECSSINHFYGFYDECKRRY-TVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDILWSDPDLRIMGWGPNERGVS
||..||. ||||.||||||  ..|. .| | .| |||.|.| . |.| |||||..| |..|.||..||.. .|. |  |.||.||.  . || .|.||||
eceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrGvs

HTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFRVQRPI
 .||.|||  .|......|..|.|||| |||||||...|.||||||.|||.|||. |.| ....| ..|.| .| 
vvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpe
subfamily_PPZ_pd Subfamily PPZ 24-313 2.1e-113 371.8 In-house 3-295 (300) alignment 
Range on Protein: 24-313
Range on HMM: 3-295/300.0
LDQIIAKLKLIGEIG---SVVQISVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLL
.|.|| ||   |        | .   ||  .| .|||..| ||.|||.  .....||.|||| .||| |   |.|| . ||.|||||||||||.||. ||
ideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletilll

LALKARYPTKFYLLRGNHECSSINHFYGFYDECKRRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDILWS
|. | .|| .|.||||||||. . . ||||||||||  .|.|.|||| .| ||||||.  .||| |||||| | ||..|| . || ..|. ||| |.|||
lcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllws

DPDLRIMGWGPNERGVSHTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFRVQRPIL
||      |  ||||||. .    .  || .| ..|.|| | |||||||||  | |.|.|||||||||||| ||.|.... |||.| .  |. 
dptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldpld
0045823 Metallo-dependent phosphatases 34-313 8.5e-112 367.1 In-house 34-325 (473) alignment 
Range on Protein: 34-313
Range on HMM: 34-325/473.0
IGEIGSVVQISVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYL
|  .    .......  ....|.|.| |.|.|||....|  .||||||.  ||| .| .|.||.  ...|||.|||| .|.|.| |||||| .||....|
iehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfl

LRGNHECSSINHFYGFYDECKRRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDILWSDPdLRIMG-----
||||||.  .|  |||.||. ..|...|.. |... ..|||||.|...|...||||||.| ...||||| ||.|||..||..|.|||||   ..|     
lrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddgdgllr

---WGPNERGVSHTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQ------LITIFSAPNYCGEFDNAGAMMCINQDLlCTFRVQRPIL
   .|.. ||....|| |.|  ||....|.||.|||..|..|||.. ...      .||.||||||||...| .|...|..|| ..|.. .|. 
lrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsp
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 22-312 1.5e-111 365.4 In-house 1-294 (299) alignment 
Range on Protein: 22-312
Range on HMM: 1-294/299.0
INLDQIIAKLKLIGEIGSVVQISVRE--IEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTL
...|....||  .|  .. .  ||.|  .  .|. |..|...|..|||. ||| . ||||||| .||| |. .|.|||. .|.||||||||.| .|..||
ldvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitl

LLALKARYPTKFYLLRGNHECSSINHFYGFYDECKRRYT-VKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDIL
||. | .|| .|..||||||| .||  ||||.||..||.  .||  | |... .||. .|   |.| ||||||.| ...|.|.. || . |.  |  |.|
llcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidll

WSDPDLRIMGWGPNERGVSHTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFRVQRPI
|.|||  ...| .| ||||. || |||.  ..|....|..| ||||.|||||||...|.|||||| |||.|||. |.| ....|.||| | .| 
wadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkpt
0049330 Metallo-dependent phosphatases 38-311 7.2e-108 353.2 In-house 25-298 (309) alignment 
Range on Protein: 38-311
Range on HMM: 25-298/309.0
GSVVQISVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGN
  ....|..|.  .. .|.|.|...|.|||....|   ||||||.  ||| .| .|.||.  ...|||.|||| .|.|.|.|||||| .|| ...|||||
lklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvfllrGN

HECSSINHFYGFYDECKRRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDILWSDPDLRIMGWGPNERGVS
||.  .| .|||.||..|.| ..||. |.|....|||||.|...|.|.||||||.| ...||||. ||.|||. ||.||.|||||.  . |..|| ||..
HElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpiregfapnprglg

HTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFRVQRP
..|| ..|  ||....|.||.|||..|..||..|....|||.||||||||...|.||...|..||...|.. .|
vvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfep
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 43-315 1.4e-107 352.0 In-house 6-278 (280) alignment 
Range on Protein: 43-315
Range on HMM: 6-278/280.0
ISVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSS
|   .|..|  . ...|. | |..|. ||... ||.|||| .||| |.  ..|||. ||.||||||||.| .| . |||| |.||| .|..||||||. |
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

INHFYGFYDECKRRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDILWSDPDLRIMGWGPNERGVSHTFGS
||. |||.||.||||. .|.  | . .. |||.|..   |.| |||||..| |.....|.|||.. ... |  |.||.||. .. ||. | ||||. ||.
inrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifga

DVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFRVQRPILSE
.||  . ......||.||||||.|||||||...|.|.||||.|.|||||. |.. ... |  .| | .| | |
nvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpalre
PP2Ac_SM00156 46-309 1.2e-106 348.7 In-house 4-267 (271) alignment 
Range on Protein: 46-309
Range on HMM: 4-267/271.0
REIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSSINH
 |. .......|.| ....|.|. ||.   ||||||.  ||| .|..|.||.. |..||||||||.||||...||.||| .||.|..|||||||.||.| 
eevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvnk

FYGFYDECKRRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDILWSDPDLRIMGWGPNERGVSHTFGSDVV
.|||..|.||.|. ...  | .....|||||.....|.| ||||||.| |...||...|. |.||.||..|.|||||. . .|. |. ||.|..||.|.|
iygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFgedav

SAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFRVQ
. ||....|.||.|.|.||..||||||...|.|||||||||.||.|..|.. ....| ... . 
keflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieql
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 45-311 2.3e-102 335.3 In-house 10-282 (284) alignment 
Range on Protein: 45-311
Range on HMM: 10-282/284.0
VREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYP------PDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNH
 .|.  .| ||||.. |..  ||| ||... ||||||. .||  .. ||.|       .. ||.||||||||  ||| .|||.|.| ..| | .||||||
ekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnh

ECSSINHFYGFYDECKRRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDILWSDPDLRIMGWGPNERGVSH
|   .|  |||| |||.||...|. .|  ..|..||.|.....|.| |||.| .|....|. ...|||.||. |.|.|. |.||. ...|.   .||  .
esrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprgagk

TFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFRVQRP
.||.. |  ||..|||.|. | |||| ||||||| |.|.|||||| |||..||..|.. ....|...| | .|
vfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
PPP_3 43-308 6.2e-102 333.2 In-house 2-268 (271) alignment 
Range on Protein: 43-308
Range on HMM: 2-268/271.0
ISVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSS
.| .|.. ......|.| |...|.|| ||.. .||||||.  ||. |.. | .|.. || |||||||||.|.|.|.|||||| .||....|||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INHFYGFYDECK-RRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDILWSDPDLRIMGWGPNERGVSHTFG
||. |||..|.. .... |..... .....|||||.|.|.....||||||.. |..||....|.||.||.|...| |.|... .  |.....||.. .||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

SDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFRV
.||.. ||.. ||.||.| |...|.|||........|.|||||||....||||.. ....| ..|..
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkq
0053225 Metallo-dependent phosphatases 34-311 2.5e-100 328.5 In-house 13-290 (293) alignment 
Range on Protein: 34-311
Range on HMM: 13-290/293.0
IGEIGSVVQISVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYL
|. .  ....|. |.  ..  |.|.|.|.|.|||....|  .|||||..  ||. .|  |.||.. ...|||.|||| .|.|.|.||||||..||....|
ielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvl

LRGNHECSSINHFYGFYDECKRRY-TVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDILWSDPDlRIMGWGPN
||||||.  .| .|||.||..|.|   .||. ..|....|||||.|...|...||||||.| ...||||| ||..||. ||..|.|||||| ...||.|.
lrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.lwsgwlps

ERGVSHTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFRVQRP
 ||....|| ..|  ||....|.||.|||||| |||... ...|.|.||||||.|...|.||.......|...| . .|
yrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 44-315 9.9e-100 326.6 In-house 4-277 (284) alignment 
Range on Protein: 44-315
Range on HMM: 4-277/284.0
SVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSSI
.  ..|..  .| ... ||| |.|. .|||. ||||||. .||| |. ||.|  . ||.|||||||||. .||. ||.| |  .| .|..|||||||| |
ppedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecsli

NHFYGFYDECKRRYTV-KLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPES-GLICDILWSDPDLRIMGWGPNERGVSHTFG
|. ||||.||.|||    .. .|   .  .||.|.. . |.| |||.|  |  . |.| |.||.. ||   |  |||||||     || || ||||. ||
nkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfg

SDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFRVQRPILSE
|| .  .| |....|. | ||||.|||||||.|.|.|||||| |||.|||| |.| .|..|.|.| | ||    
sdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkki
PPP_1 46-296 1.1e-98 322.7 In-house 4-262 (264) alignment 
Range on Protein: 46-296
Range on HMM: 4-262/264.0
REIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSSINH
.|. .......|.| |...|||. ..| . ||||||.  ||. |.  | .|.. || |||||||||.|.|.|.|||||| .|| ...|||||||......
eelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtk

FYGFYDECK-RRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDIL-------WSDPDLRIMGWGPNERGVS
 |||..|.. ..|. ....|..|....|||||.|.|.|...||||||.| ...|||..|| .|.||.| .|| |       .||.. . ...  ..||..
vygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGag

HTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMM
..||.||.. ||....|.||.| |.|.|.||||..||...|||||.||. |..|.||..
ylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayv
subfamily_PPP4C_pd Subfamily PPP4C 35-308 6.3e-93 304.1 In-house 8-281 (288) alignment 
Range on Protein: 35-308
Range on HMM: 8-281/288.0
GEIGSVVQISVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLL
 .. ..  |. .|..|.|..|||.|...  . .. .|. . ||||||. .||. |. .|  |.  ||.|||.||||. |.||. ||||||.||| . .|.
eklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritli

RGNHECSSINHFYGFYDECKRRYT-VKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDILWSDPDlRIMGWGPNE
|||||. .| . ||||||| |.|  ...||  .. .. |.|||||...||| ||||||.. ....|| | | .|.|..| .||.|||||.  . ||.   
rgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpe.daegwavsp

RGVSHTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFRV
||  . ||||||. | .. ...|||| ||.| .|| .  .....|..||||||    |  |.. ....|   |..
rgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfki
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 41-306 1.5e-92 302.8 In-house 6-271 (281) alignment 
Range on Protein: 41-306
Range on HMM: 6-271/281.0
VQISVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHEC
||.. .|||.|   .. .. .. .| || .|| ..||.|.|. .| | ||  | .|. |...||||||||.||.|.| ||..|| ||. . .||||||| 
vqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhei

SSINHFYGFYDECKRRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDILWSDPDLRIMGWGPNERGVSHTF
.|.|. |||| ||. .| ..||  |  |.| ||..| |.. . | |||||| | .....|.. .||. .. ||. |.||.||| . ..|    ||.|.||
asvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftf

GSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTF
| .||     |....|| |.|||| |||| .. |.|||.||.||||  . ||.|.......|  ..
GknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgisl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 99-311 3.4e-92 302.0 In-house 102-314 (317) alignment 
Range on Protein: 99-311
Range on HMM: 102-314/317.0
VYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSSINHFYGFYDECKRRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQ
 ||.||||||||  ||| ..||.||| .|| | .|||||||  ..|  |||| |.|.|| ..|. .|   .|.|||.|.....|.| |||.| .|....|
kylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlkq

IREIRRPIEIPESGLICDILWSDPDLRIMGWGPNERGVSHTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCI
. ...||..||. |...|. |.||| .. |. . .|| .. ||.. | .||....|.|. |.|||||||||||| |.|.||||||.|||..||..|.. .
ldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavlsv

NQDLLCTFRVQRP
...| ... | ||
dkklkisinvlrp
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 53-312 5.4e-92 301.2 In-house 33-295 (297) alignment 
Range on Protein: 53-312
Range on HMM: 33-295/297.0
SRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSSINHFYGFYDE
  | .|. .| ...|. |||.. ||||||. .||| |   |.|| . ||.||||||||. ||||. |||| | ..|....||||||||  .|. ||||.|
dlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkvygfyee

CKRRY-TVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSP---HLFSMQQIREIRRPIEIPEsGLICDILWSDPDLRIMGWGPNERGVSHTFGSDVVSAF
|..|| .|... .| | .| |||. .| ..|.| ||||||   . |... .|.| |. |  | .|..|.||.||   . |.  |.||    || | |   
cqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegke.rlvadllwadpisglsgfmenqrgagcgfgrdavlkl

LHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFRVQRPI
   |||.|.|| ||||.||||||| |.|.|||||| |||.|||. |.|  .. | |.| . || 
csefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
subfamily_PPP2C_pd Subfamily PPP2C 34-307 3.9e-91 298.2 In-house 8-281 (290) alignment 
Range on Protein: 34-307
Range on HMM: 8-281/290.0
IGEIGSVVQISVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYL
| .. .  |..  |....| .|.|.| |.  . |. .|. . ||.|||. .||  |   |  ||. ||.||||||||  |.||.||| ||| ||. .  .
ieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeriti

LRGNHECSSINHFYGFYDECKRRYT-VKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDILWSDPDLRiMGWGPN
||||||   |   ||||||| |.|.  ..|. | | ...|||.|...|.||| ||||||.. ....||.. |  |.|. | .||.|||||| |  |||  
lrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddr.ggwgis

ERGVSHTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFR
.||  .||| |.  .| .. .|.|| | ||.| .||..  .|...|||||||||    | .|.. ....|  .| 
prgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysfl
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 39-311 1.1e-87 286.6 In-house 6-281 (287) alignment 
Range on Protein: 39-311
Range on HMM: 6-281/287.0
SVVQISVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNH
 .  .| ..|  |  ...|.|   |.|||. |||...||||||. .|||.|.. |..|.  ||.|||||||| .|.|   ||..|| .|| | .||||||
vldafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnh

ECSSINHFYGFYDECKRRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPE--SGLICDILWSDPDLRIMGWGPNE-RG
|.  ||. |||..| ||..  .|...| | .. ||| |.... |.| |||.||.| |..... ...|    .   ||. |.||.||.    .  .|  |.
evkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkira

VSHTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFRVQRP
.|  ||  .|  .|......|| | |.|.|.||.|.....|.|.|||| |.||  | ||.. ... |  .| | .|
isvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp
subfamily_PPP6C_pd Subfamily PPP6C 43-307 4.3e-85 278.4 In-house 15-279 (290) alignment 
Range on Protein: 43-307
Range on HMM: 15-279/290.0
ISVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSS
..  .....|..  ..||.. ..  . .|. . ||||||. .|.  | . |  ||. |..|||.||||  |.||.|.||.|||.|| .  |||||||.  
lpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrq

INHFYGFYDECKRRYT-VKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDILWSDPDlRIMGWGPNERGVSHTFG
| . |||||||...|  .. |. ... .. |..||||.|...| ||||||..  ..||| | | .|||. | .||..||||.  .  |   .||  . ||
itqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpe.dvetwavsprgagylfg

SDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFR
| |.. |.|  .|.|||| ||.||.|.... . .|.|..||||||    |  ... ....   ...
skvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereak
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 45-308 7.4e-83 271.2 In-house 8-271 (280) alignment 
Range on Protein: 45-308
Range on HMM: 8-271/280.0
VREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSSIN
 .|| |.      .....  | |  |||...|||| || .. | |.  |  |.   ..|||||||| | || | ||..|| ||  . ||||||||  |.|
gheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvn

HFYGFYDECKRRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDILWSDPDLRIMGWGPNERGVSHTFGSDV
. |||| ||. .| | ||  |  |.| .|....| . ..| |||||| |  .. ||.| ||.|  . ||. |.|||||  .  ||  . ||.|. ||  |
kiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgv

VSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFRV
|    . ....|| |.||||.||||..| |.|||.|| |||| .| || |..|.| .|  .|. 
veqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqq
subfamily_PPP3C_pd Subfamily PPP3C 42-303 2.5e-82 270.0 In-house 40-314 (452) alignment 
Range on Protein: 42-303
Range on HMM: 40-314/452.0
QISVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECS
... ...  . ..| ..| |..||||. ||| ..||||||...||. || .| | .. ||.||||||||  |||..  |.|||  ||....|||||||| 
rleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecr

SINHFYGFYDECKRRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDILWSDPDLR------IMGWGPNE-R
 . ... | .||| .|. ... ........|||||..... .|.||||||.. |...|... |  |.|.||..||.|||||  .         . ||. |
hlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvr

GVSHTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAK------RQLITIFSAPNYCGEFDNAGAMMCINQDLL
| |. ..   |. ||.. .|  | | |.. ..||. . |        |||.||||||.. ..| .|.. .... .
GcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 38-311 4.4e-77 251.9 In-house 11-288 (290) alignment 
Range on Protein: 38-311
Range on HMM: 11-288/290.0
GSVVQISVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGN
| .  .| ..|  .  ...|.|   |.|||. ||| ..||||||  .|||||.. ||||.  .|.|||||||| .|.|   ||. .| ||. | .|||||
gvldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgn

HECSSINHFYGFYDECKRRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIE--IPESGLICDILWSDPDL-RIMGWGPN-E
||.  .|..|||..|  |. . .||. . | .. |.| | ....|.| |||.|... | . .. ...|      . ||. |.||.||.  .      |  
hevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkq

RGVSHTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFRVQRP
|..|  || ...  .|... |.|| | |.| |.|..|  ...|.|.|||| |.|.  | ||.. . . |  .. | .|
raisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkp
subfamily_PPP5C_pd Subfamily PPP5C 48-304 6.3e-77 251.7 In-house 39-301 (322) alignment 
Range on Protein: 48-304
Range on HMM: 39-301/322.0
IEAVCSRAREVLLKQPTLLEIPAP----INLLGDIHGQYLNLLRYFESNGYPP-DSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSS
. .. ..|.|.| |.|.|.||  .    . . ||||||...||  || ||.|  .  ||. ||.||||  |.|.. .||..|  || .|.| ||||| ..
alkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdn

INHFYGFYDECKRRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGL-SPHLFSMQQIREIRRPIEIPESGLICDILWSDPDlRIMGWGPNERGVSHTFG
.|..||| .|.| .|| |.   | . .| |||| .|.|... .|||| | .  .....|.| |  . ||.||....|||||. . .| .| .|||...||
mnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpq.eanGrspskrGvgvqfG

SDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCI-NQDLLC
 || . ||.  .|.|| | |.| |.|||.  . .|||.||||||| . .| ||.. . ..||  
pdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlkl
subfamily_PPG1_pd Subfamily PPG1 47-306 2.2e-76 250.0 In-house 18-290 (300) alignment 
Range on Protein: 47-306
Range on HMM: 18-290/300.0
EIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSSINHF
 ..... . .|.|.|.  . || .|. ..||.|||. ..|  |.  |  ||. ||.||||||||  |.||..||..|| |||..  |||||||   |   
tvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqv

YGFYDECKRRY--TVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDILWSDPD---------LRIMG--WGPNE
|||| || |.|    ..|. . . .. | |||||.|.|.| ||||||   |..||. . |  |.|. | ..|.|||||.             |  .   .
ygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsq

RGVSHTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTF
||  ...| |||  ||.  ..| | | ||.. .||. .   .| |..||||||    |  ... ... .   |
rgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyf
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 100-312 2.7e-74 243.3 In-house 122-334 (339) alignment 
Range on Protein: 100-312
Range on HMM: 122-334/339.0
YLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSSINHFYGFYDECKRRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQI
||.||||||||  |.| . || |||  || . ||||||||  |.|  |||| | . ||  .|.  | . .| .|..|.|.. |.| |||.| || |..|.
ylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnqf

REIRRPIEIPESGLICDILWSDPDLRIMGWGPNERGVSHTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCIN
  ..||.|||. |.. |. |.|||    |. |  || |  ||   . |||... |... |||||||||||||  |.|.||||||||||. ||. |.. |.
svfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsid

QDLLCTFRVQRPI
. |  .  | || 
kklkisinvfrpe
PPP_2 72-263 1.2e-71 233.5 In-house 1-197 (198) alignment 
Range on Protein: 72-263
Range on HMM: 1-197/198.0
INLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSSINHFYGFYDECK-RRYTVKLWRTFVDCYN
....||.|||.  ||. |.. . .|.. || |||||||||.|.|.|.|||||| .||....|||||||....|. |||..|.. .... |..... ....
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

CLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDIL----WSDPDLRIMGWGPNERGVSHTFGSDVVSAFLHRFKLNLICRGHQV
.|||||.|.|.....|||||... ...||....|.||.||.|...| |    .|||. .  .. ...||.. .||.||.. .|...||.||.| |.|
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 73-263 1.1e-70 230.7 In-house 2-196 (197) alignment 
Range on Protein: 73-263
Range on HMM: 2-196/197.0
NLLGDIHGQYLNLLRYFESNG-YPP-DSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSSINHFYGFYDECKRRYTVKLWRTFVDCYN
   ||||||. .|| ..  ||  |. .. |. |||||||||.|.|.|.|||||| .||....|||||||..|.| .|||..|...... ...... |...
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

CLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIP-ESGLICDI-LWSDPDLRIMGWGPNERGVSHTFGSDVVSAFLHRFKLNLICRGHQV
.|||||.|.|.....|||||..| |...|..|.|.||.| |.....|. |||||  .  |. ...||....||.||.. ||.. .|.||.|.|..
llplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 65-317 1.5e-67 221.0 In-house 2-261 (263) alignment 
Range on Protein: 65-317
Range on HMM: 2-261/263.0
LLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSSINHFYGFYDECKRRYTV-----
|||. ||||. || |||| .||| |.. |    . ||.|||||||| .|.| . ||..||   | |..|||||||  .||. |||. | |.|.       
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPES-GLICDILWSDPDLRIMGWGPNE-RGVSHTFGSDVVSAFLHRFKLNLI
 ..  | . .. .||.||. . |.| |||.|||| |...|| |  |.|  ..  | ||.||.||.    |. ||. | .|  ||   |  . .|. ..||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFRVQRPILSEQR
 | ||||| || ||| |.|||.|||  |  |. |  |.. .|. |  .|   .|   | |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpedfevr
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 41-302 2.7e-67 220.1 In-house 18-282 (307) alignment 
Range on Protein: 41-302
Range on HMM: 18-282/307.0
VQISVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHEC
.| .  |.| |   |. ..  . .|..|  |  ..||.|||. .|.  |   | ||..||.. |||||||  |.|.. ||.. |  || .  ||||||| 
iqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnhei

SSINHFYGFYDECKR---RYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDILWSDPDLRIMGWGPNERGVS
. .|. ||||.||     .   ..|  |  |.| ||..|.|  .|.| |||||| |  ....|.  .||  |  |.. |.||.|||  .. |    ||  
arvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsg

HTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDL
 |||..|.    .|. ..|| | ||.. |||  .. |.|||||||| ||  . |||... ... |
ftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetl
PPP_5_Dcr2 73-264 3.6e-67 219.2 In-house 2-199 (199) alignment 
Range on Protein: 73-264
Range on HMM: 2-199/199.0
NLLGDIHGQYLNLLRYFESNG-YPP-DSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSSINHFYGFYDECKRR-YTVKLWRTFVDCY
  .||.|||. .|| ... .|  |. .  |. |||||||||.|.|.|.|||||| .|| ...|||||||....| .|||..|.... .  |..... |..
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIP-ESGLICDI-LWSDPDLRIMG-WGPNERGVSHTFGSDVVSAFLHRFKLNLICRGHQVV
..|||||.|.|.....||||||.. |......|.|.|||| |.|  .|. |||||  .  | . ..|||....|| ||.. ||.. .|.||.|.|...
dwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 44-301 2.2e-66 217.1 In-house 7-289 (302) alignment 
Range on Protein: 44-301
Range on HMM: 7-289/302.0
SVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYP-----------PDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFY
|  |. ....   | | |. || || .|. ..||||||. .|.| . ..                . ...||||||||..||| ..|..|||  |||.. 
sksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyi

LLRGNHECSSINHFYGFYDECKRRY----TVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPI-EIPESGLICDILWSDPD----
|||||||. .||. ||| .| . |.    . ..|. | ...  .||||.. |.|.| |||.||.| |...|..|.||. |. |  |  |.|..||     
llrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvql

LRIMGWGP-----NERGVSHTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQD
| ..   |     . ||.|..|    |  . .|. |.|| |.||..  |. |||...|.||||||.|  | || ||.. .. .
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 44-301 4e-66 216.2 In-house 8-290 (302) alignment 
Range on Protein: 44-301
Range on HMM: 8-290/302.0
SVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYP-----------PDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFY
|  |. ....   | | |. || || .|. ..||||||. .|.| . ..                . ...||||||||..||| ..|..|||  |||.. 
sksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyi

LLRGNHECSSINHFYGFYDECKRRY----TVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPI-EIPESGLICDILWSDPD----
|||||||. .||. ||| .| . |.    . ..|. | ...  .||||.. |.|.| |||.||.| |...|..|.||. |. |  |  |.|..||     
llrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvql

LRIMGWGP-----NERGVSHTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQD
| ..   |     . ||.|..|    |  . .|..|.|| |.||..  |. |||...|.||||||.|  | || ||.. .. .
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn
subfamily_PPPLV_pd Subfamily PPPLV 49-303 7.9e-57 185.8 In-house 3-280 (290) alignment 
Range on Protein: 49-303
Range on HMM: 3-280/290.0
EAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLlRYFESNGYP-----PDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSSI
 ..|. | ..|...  |||. .|. .|||.||.| .|  |||.  .        . .|.||||||||. |.| .. |||||  ||.|..|||||||  |.
lslcdvavdilaaeerllelksptyvlgdlhgnyrdl.iyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesv

NHFYGFYDECKRRYTVKL---WRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQ---QIREIRRPI--EIPESGLICDILWSDPD----LRIM----
 . . .. |.. ..  .|   | .| .... |||||.|....||.|.|.     .      |..|   .  .|  . |  |||||||.    | ..    
qesieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelv

---GWGPNE-RGVSHTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAgAMMCINQDLL
   |. .|. || .| |..| . |||.|  |. . | |.| | |...  | .|.|.||. .|||  ..| |.. .... |
lneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssnea.alilvdkkkl
Metallophos Calcineurin-like phosphoesterase 71-263 2e-42 138.8 Pfam-A 2-198 (200) alignment 
Range on Protein: 71-263
Range on HMM: 2-198/200.0
PINLLGDIHGQYLNL----LRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLL--LALKARYPTKFYLLRGNHECSSINHFYGFYDECK----------
.| ..||.||..  |    |.... .....  ..| |||.||||. |.||| ||  |.|| ..|....|||||||....| .|||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------RRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIreirrpieipesglicdilwsdpdlrimgwg
                         ... . .. . .....|||.|... .|...||.||... |  .|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

pnergVSHTFGSDVVSAFLHRFKLNLICRGHQV
      |  ||.|... .| . .. |..|||. 
.....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 56-204 1.2e-33 109.4 In-house 46-201 (383) alignment 
Range on Protein: 56-204
Range on HMM: 46-201/383.0
REVLLKQPTLLEI----PAPINLLGDIHGQYLNLLRYFESNGYP-PDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSSINHFYGFY
..|| . | . ..       . . ||.||.  .||  .  ||.| ..  |.. ||.|||||.|.| | .||||   ||...|| ||||| . .|  ||| 
kkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfi

DECKRRY---TVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHlFSMQQIREIRR
 | . .|   . |. |.. | .  ||||..|.|.|. .|||.| .  ... . .| |
keveskykvhgkkilrlledvfawlplatlidekilivhGGisdk.tdlelldkier
subfamily_PPP7C_pd Subfamily PPP7C 213-306 3.4e-21 68.4 In-house 236-329 (383) alignment 
Range on Protein: 213-306
Range on HMM: 236-329/383.0
LICDILWSDPDLRIMGWGPNERGVSHTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMCINQDLLCTF
 . |||||||  .   .    ||    ||.|| . .|....|.|. | |.   .||||  .....||||| ||  |  | || . ...||   .
qvldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpri
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 45-95 5.4e-14 45.1 In-house 11-61 (317) alignment 
Range on Protein: 45-95
Range on HMM: 11-61/317.0
VREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYP
 .|.  .| ||||.. |.|  ||. ||. ..||||||. .||  .. ||.|
ekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 43-97 4.9e-11 35.3 In-house 11-65 (339) alignment 
Range on Protein: 43-97
Range on HMM: 11-65/339.0
ISVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESNGYPPD
.   |.  .| ||||..  .| .|.. ||| ..||||||. .||  .. ||.|  
fcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwpls
subfamily_YNL217W_pd Subfamily YNL217W 74-201 1.4e-07 24.2 In-house 14-149 (235) alignment 
Range on Protein: 74-201
Range on HMM: 14-149/235.0
LLGDIHGQYLNLLRYFE--SNGYPPDSVYLLLGDYVDRGKQSIETLTLLlalkarYPTKFYLLRGNHECSSIN------HFYGFYDE--CKRRYTV--KL
. ||.|| | .|.. ..    |  .. . .|.|| ...| .|.|.. ..        .. . ..||||   .       .  |. .    ..  ..  ||
vvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsfleskl

WRTFVDCYNCLPLA-AIIEENIFCCHGGLSPHLFS-MQQIRE
 .  .. .  |. .  |  ....  |.||.|  |   ..| |
skadmeyarelgfsldipsdellvvhaGlvpgkfleenside