Gene PpY-55A in Drosophila melanogaster

Synonym: CG3245, DmPpN-58A, Dmel\CG3245, PPN, PPN 58A, PpN-58A, Dmel_CG3245, PpN58A

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP095_AA protein Get Run
DmelP095_AA_11-298 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP1C_pd Subfamily PPP1C 20-297 2.2e-144 472.8 In-house 4-281 (282) alignment 
Range on Protein: 20-297
Range on HMM: 4-281/282.0
NGSECTLKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRG
.|.|..|||. ||.|....||... ||.||||.|||.|.||||||..||||.|...|.||..|||||||||||||||||||.||.|||.||| |.|||||
kgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrG

NHESASINKIYGFYDEIKRRHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLNHTTKGWGHNDRGV
||||||||.|||||||.|||....||..|||.||.||.|||| |.|.|.||||||.|..|.||..||||...|..|..|||||.| .....||..|||||
nhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGv

SFTFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVIILPCHK
||||.| .|..||. .||.|.||||.||||||||||.||||||||||||||...|||.|.||...|..|| |. |..|
sftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpakk
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 24-297 1.3e-126 414.7 In-house 22-296 (298) alignment 
Range on Protein: 24-297
Range on HMM: 22-296/298.0
CTLKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHES
 ..||| .|.||.......| |..|.|..||...|||||||..||||.|. .||||.|||||||||||||.|.||.|.||.||||||| |||||||||| 
kvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnhec

ASINKIYGFYDEIKRRH-TVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLNHTTKGWGHNDRGVSFT
..||..||||.|.|||.  .||...| | ||.||..||.|.||.| |||||. |..|.|.....||.| ..| .  |||||| ....||| .| ||||..
eainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrGvsvv

FDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVIILPCHK
| .  |.|.|. .|. |.|||| || |||||||...|||.||||.||| ..|. .||.|. .|..||... | .|
fGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekk
subfamily_PPZ_pd Subfamily PPZ 24-294 9.9e-118 386.0 In-house 23-293 (300) alignment 
Range on Protein: 24-294
Range on HMM: 23-293/300.0
CTLKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHES
  ||.. | .. ...||..  || ||||  .|.| ||.|||..||||.|  |||||.|||||||||||||||||||| ||..||.||| |||||||||| 
vclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhec

ASINKIYGFYDEIKRRHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLNHTTKGWGHNDRGVSFTF
| . ..|||||| |||  ...|..| | || ||.||.|  .||| |||||| | ....| |. ||||.|| |.. ||||.|   ... |  |.||||. .
anvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycy

DKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVIILP
.|| .  ||. | ..|..||| ||||||||| .| |||||||||||| ..| | |||||  |.||| .. |
nkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 24-295 7.4e-112 366.0 In-house 5-275 (280) alignment 
Range on Protein: 24-295
Range on HMM: 5-275/280.0
CtLKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHES
| .||  |.|.|.. ..... |  ..|..|||..|||.|||.|||||.|. ..|||  ||||||||||||.| || |.||.||||.|| ||..|||||| 
c.ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhev

ASINKIYGFYDEIKRRHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLNHTTKGWGHNDRGVSFTF
.|||. |||.||.|||..  |.  | . .. ||..|||. ||.| |||||. |. |.......|| | .|| .  |||||| .  . ||..| ||||  |
isinrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvif

DKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVIILPC
 . .|.|. . .|..|..| |.||.|||||||...||||||||.|.| ..|. .|. |.  || || .. | 
ganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
PP2Ac_SM00156 27-291 1.5e-111 364.8 In-house 2-266 (271) alignment 
Range on Protein: 27-291
Range on HMM: 2-266/271.0
KEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESASI
..| . .|.....|..| ...|.|..||| ..||||||..||||...  |.||. .|.|||||||||.||.|.|.||||.|..|| ...|||||||| |.
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NKIYGFYDEIKRRHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLNHTTKGWGHNDRGVSFTFDKV
||||||..|.||... .... |...|..||.||||...|.| ||||||.|..|..|....|. ..|.||...||||.| ....||. .. ||.|..| . 
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

IVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVI
.|..|||...|.| .||||||..||||||...|||.|||||||. ..|.. |..|...| .|.. 
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieq
0045823 Metallo-dependent phosphatases 12-297 9.5e-111 363.6 In-house 29-326 (473) alignment 
Range on Protein: 12-297
Range on HMM: 29-326/473.0
IIKELTSLNGSECTLKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYP
....|..    |..|.|| . .|.....|..| .|.||||.... ..||||||..||||... .||||. ...||||.|||| .|||...||.|.|.|||
dldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikyp

LNFFLLRGNHESASINKIYGFYDEIKRRHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLnHTTKG
 |.||||||||.. .| .|||.||. .. ...|.. | .....||.||..|..|...||||||.|..|.||..|.|| .|||.|...||||.|   ...|
gnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddg

--------WGHNDRGVSFTFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQ------LVTVFSAPNYCGMMNNAGGVMSVSTDLiCSFVIILPCHK
        .|.. ||....|.. .|..||| ..|.|.||.|..|..|||.. ...      ..||||||||||...| ..|. .. || .||... |.  
dgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsph
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 24-297 5.5e-110 360.3 In-house 22-296 (299) alignment 
Range on Protein: 24-297
Range on HMM: 22-296/299.0
CTLKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHES
 ..||. . .| . ...|.  |. |||..||. .|||||||..||||||.  ||||..|.||||||||||.| ||.|.||...|.||| .||.|||||| 
ksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhec

ASINKIYGFYDEIKRRH-TVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLNHTTKGWGHNDRGVSFT
 .||..||||.| ..|. . |||  | |.|...|.. |.| ||.| |||||| |..|.|. ...|| | |.  .  |||||| ... |.|  | ||||. 
painrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyv

FDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVIILPCHK
| . .|.| .. .|..|. |||.||.|||||||...|||.|||| ||| ..|.  .| |  .|.|.||.. |. |
fgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpk
PPP_3 26-291 9.1e-108 352.3 In-house 2-268 (271) alignment 
Range on Protein: 26-291
Range on HMM: 2-268/271.0
LKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESAS
|.|. ...|.....|... ...|.|..|||..|||||||..|||..|| .|..|. .||||||||||||.|||...||.|.|.||| ...||||||||..
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INKIYGFYDEIK-RRHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLNHTTKGWGHNDRGVSFTFD
|||.|||..|.. .... .... ....|..||.|||. |.....|||||||...|.||....|....|.|| ..|||. . .....|.....||....| 
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

KVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVI
. ....||.. .|.|..||||..|.|||.......||||||||||. ..||| .......| ..|..
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkq
0049330 Metallo-dependent phosphatases 12-298 6.5e-106 346.8 In-house 16-302 (309) alignment 
Range on Protein: 12-298
Range on HMM: 16-302/309.0
IIKELTSLNGSECTLKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYP
....|..|   . .|.|| . .|.....|..| .|.||||.... ..||||||..||||.....||||  ...||||.|||| .|||...||.|.|..||
lldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllyp

LNFFLLRGNHESASINKIYGFYDEIKRRHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLNHTTKG
 |.||||||||.. .| .|||.||..|.  ..||. |.|....||.||..|..|.|.||||||.| .|.||....||..||..|..|||||.| . ...|
dnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpireg

WGHNDRGVSFTFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVIILPCHKY
...|.||....|.  .|..||| ..|.|..|.|..|..||..|....|.||||||||||...|.|.|. .. || .||... |.  .
fapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 29-297 6.8e-106 346.8 In-house 6-276 (284) alignment 
Range on Protein: 29-297
Range on HMM: 6-276/284.0
ELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESASINK
| .| |. .. .... ||||.| ..|.||||||||||.||||.|   ||| .||||||||||||||. |||| ||||||| .|  ||.|||||| . |||
edvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

IYGFYDEIKRRHT-VRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEG-IMCDLLWADLNHTTKGWGHNDRGVSFTFDKV
|||||.| .||.    ...||   |  .|..||||.||.| |||.|  |.|. |.  |.|| | |.   .  |.||.|     |||  | ||||. |   
iygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsd

IVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVIILPCHK
 .| .|  ....|.||||.||.|||||||||.|||.|||| ||| ..||  || |  .|.||||.. | .|
alrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkk
PPP_1 27-280 3.9e-104 340.6 In-house 2-263 (264) alignment 
Range on Protein: 27-280
Range on HMM: 2-263/264.0
KEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESASI
.|| . .|.....|... ...|||..... .||||||||.|||..||..|..|. |||||||||||||.|.|...||.|.|.||| ..|||||||||...
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

NKIYGFYDEIK-RRHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLL-------WADLNHTTKGWGHNDRG
.|.|||..|.. .... .... .||.|..||.|||. |.|...||||||.|. |.||....| |..|.|| .||||       . | ....... ...||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VSFTFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMS
....| | ....||....|.|..|||||.|.||||...|..||.|||.||.  ..|.| ...
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 26-293 1.6e-100 329.2 In-house 8-281 (284) alignment 
Range on Protein: 26-293
Range on HMM: 8-281/284.0
LKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFP------PKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRG
|||. . .|  ..||..  ... ||..|||.|.||||||| ||| ...  |.|       . .|||||||||||  |.| | ||||||...| . |||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHESASINKIYGFYDEIKRRHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLNHTTKGWGHNDRGV
||||  .|. |||| | |.|....|...|  .|| .|..|.|...|.| |||.|  | .|.|.....||.|||| |...|| ||| . . .|. . .|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SFTFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVIIL
  .| .  |..||| |.|.|.||||.|| |||||||.|.|||.|||| ||| ..|.. |..|...|..||... 
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk
0053225 Metallo-dependent phosphatases 12-295 9.6e-98 320.1 In-house 8-291 (293) alignment 
Range on Protein: 12-295
Range on HMM: 8-291/293.0
IIKELTSLNGSECTLKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYP
... |..|     .|.|| . .|.....|..| .|.||||.... ..|||||...|||.... .||||  ...||||.|||| .|||...||.|.|..||
lldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllyp

LNFFLLRGNHESASINKIYGFYDEIKRRH-TVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLNhTTK
 |..|||||||.. .| .|||.||..|.    .||. ..|....||.|||.|..|...||||||.| .|.||..|.||..||.||...|||| | .   .
dnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.lws

GWGHNDRGVSFTFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVIILPC
||... ||....|.  .|..|||...|.|..|.|.|| |||... ...||||||||||.|...|.|.|. ....| ..|... |.
gwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 26-295 3.5e-96 315.0 In-house 23-295 (297) alignment 
Range on Protein: 26-295
Range on HMM: 23-295/297.0
LKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESAS
. || . .|.. . .|.| |  ..|..||...|||||||| ||||.|.  |.|| |||||||||||||. |.||| ||.|||||.| |.||||||||   
iteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecef

INKIYGFYDEIKRR-HTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSL---RNLQQINHIQRPTDiPDEGIMCDLLWADLNHTTKGWGHNDRGVSF
.||.||||.| ..| ..||.. .| | |||||.. |. ..|.| |||||| |     |. ...|.|.|.   |....||||||      |. .|.||   
vnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierste.gkerlvadllwadpisglsgfmenqrgagc

TFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVIILPC
 | .  | .    |.|.|..|||.||.||||||| |.|||.|||| ||| ..|.  .||.   | ||| |. | 
gfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 27-295 1.7e-95 312.2 In-house 11-282 (287) alignment 
Range on Protein: 27-295
Range on HMM: 11-282/287.0
KEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESASI
... |  ......|...  | |||..||..|.||||||. ||||||.|.| .|| .||||||||||| .||| . |||..|..|| .  |||||||   |
sdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkki

NKIYGFYDEIKRRHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDI--PDEGIMCDLLWADLNHTTKGWGHND-RGVSFTF
||.|||..|.||..  ||.. | | |. ||. | |..||.| |||.|| |. |.... ...||     |||.. |||||| .. .|.   |  |..|  |
nklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvf

DKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVIILPC
 |  | |.|| .|..|.||||||.|.||.|.....|||||||| |.|   | | |. ||  |  ||| . | 
GkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpe
subfamily_PPP2C_pd Subfamily PPP2C 9-291 1e-91 300.1 In-house 4-282 (290) alignment 
Range on Protein: 9-291
Range on HMM: 4-282/290.0
IDCIIKELTSLNgsecTLKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKV
.| .|..|.. .    .|.|. ...|.....|... .  . |...|| .|||.|||| ||| .||  |  |..||||||||||||  |.||..|| | ||
ldklieklkeck....qleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkv

KYPLNFFLLRGNHESASINKIYGFYDEIKRRHT-VRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLNh
.|.    .|||||||  | ..||||||  |...   .|. ||| |..||..||| |.||| |||||||.  |..|....|  ..|.|| .|||||.| . 
rykeritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.

TTKGWGHNDRGVSFTFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVI
  .|||  .||  .|| | | ..| |. .|.|..|||..| .||..  .|..||.|||||||    | .... .  .|  ||. 
drggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflq
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 27-295 1.9e-90 295.9 In-house 9-277 (281) alignment 
Range on Protein: 27-295
Range on HMM: 9-277/281.0
KEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESASI
 .| || .|.... ..  .  | |...|. . ||.|.||.|| |.|.  | .|.  ..|||||||||.||||.. |||..|..|. . .||||||| ||.
tkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasv

NKIYGFYDEIKRRHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLNHTTKGWGHNDRGVSFTFDKV
||||||| | . .  . ||  |  ||| ||..||. .|. | |||||| | .|...  . .| . .| |.. |||||| .  ...| .  ||.|||| | 
nkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGkn

IVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVIILPC
.| |  | ....|..||| || |||| .. |.|.||||.|||| . .||. |. |  .|  |.| ..| 
vvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpa
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 81-294 4.2e-90 295.1 In-house 101-314 (317) alignment 
Range on Protein: 81-294
Range on HMM: 101-314/317.0
ANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESASINKIYGFYDEIKRRHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQ
 .|||||||||||  |.| . ||||.|..|| . ||||||||| ..|. |||| |.|.|. ..|...|   || ||..|.|...|.| |||.| .| .|.
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QINHIQRPTDIPDEGIMCDLLWADLNHTTKGWGHNDRGVSFTFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMS
|.....||.|||| |...|| ||| ... ||. .  || .. | .  |..||| .||.|.||||.||||||||||.|.|||.||||.||| ..|.. |.|
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VSTDLICSFVIILP
| ..| .|. .. |
vdkklkisinvlrp
subfamily_PPP4C_pd Subfamily PPP4C 25-291 1.8e-89 292.8 In-house 15-281 (288) alignment 
Range on Protein: 25-291
Range on HMM: 15-281/288.0
TLKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESA
 .||| ...| ...||..  .  . ....|| .|||||||| |||..||  |  |. |||||||.||||. |.||. || |.||.|| .  |.|||||| 
likeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesr

SINKIYGFYDEIKRRH-TVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLNHTTkGWGHNDRGVSFTF
.| ..||||||. |.. ....|.  |. |..|..||.. ..||| |||||||...|..|  |.| ...|.||..|||||.| .... ||.   ||  . |
qitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae.gwavsprgagylf

DKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVI
 . .| .| .| |..|..|||..| .|| .  |....||.||||||    |   .. .  .|   | |
gsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfki
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 26-294 1.6e-83 273.1 In-house 16-288 (290) alignment 
Range on Protein: 26-294
Range on HMM: 16-288/290.0
LKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESAS
.... |  .... .|...  | |||..||. | ||||||. .||| |.| |.||| ..|||||||||| .|||   ||| ||..|. .  |||||||   
fsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrk

INKIYGFYDEIKRRHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTD--IPDEGIMCDLLWADLNH-TTKGWGHN-DRGVSF
.|..|||..|. |. . |||. . | |. |.. | ||..|.| |||.|. .   . .. ...|      |||.. |||||| ..  ..    |  |..| 
vnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisv

TFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVIILP
 | |  . |.|| . |.|.|||||| |.|..|  ...|||||||| |.|   | | .. ||  |  |.|.. |
vfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkp
subfamily_PPP3C_pd Subfamily PPP3C 22-286 5e-83 272.4 In-house 37-314 (452) alignment 
Range on Protein: 22-286
Range on HMM: 37-314/452.0
SECTLKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNH
 |  |.|| . ..|... ...| .. |||..||. ..||||||| |||..|.  | | ...|||||||||||  |.|..  |.| |..|| ..|||||||
kegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnh

ESASINKIYGFYDEIKRRHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLN------HTTKGWGHN
|.  . . . | .|.| ... .........|. ||.|||. .. .|.|||||| ...|..|....|  ..|  | .|||||.|        .|.. . .|
ecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpn

D-RGVSFTFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFAN------RQLVTVFSAPNYCGMMNNAGGVMSVSTDLI
. || |. .    | .||.. ||  ..||||. ..||. . .        |.|.||||||... || . |. . .. .
svrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
subfamily_PPP5C_pd Subfamily PPP5C 13-284 1.1e-81 267.4 In-house 21-298 (322) alignment 
Range on Protein: 13-284
Range on HMM: 21-298/322.0
IKELTSLNGSECTLKEELIERLIQQTREVIKWQPMLLELQAP----VNICGDIHGQFTDLLRIFKACGFPPKA-NYLFLGDYVDRGKQSLETICLLFAYK
.||| .|  .. .|..  . .......|..| .| |.|.. .    . .|||||||| ||| ||.  | | .   ||| ||.||||  |.|.| .|...|
vkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfk

VKYPLNFFLLRGNHESASINKIYGFYDEIKRRHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSP-SLRNLQQINHIQRPTDIPDEGIMCDLLWADLN
. || .||| |||||| ..||.||| .|.| ..| .. . ||. |||||.| .. |... .||||      .|... .|.| .. |.||....|||.| .
llyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpq

HtTKGWGHNDRGVSFTFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVS-TD
. ..| ..  |||...|   . . |||  .|.|..|.||| |.|||.  . .|.|||||||||  |.| |.....  .|
e.anGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgdd
subfamily_PPP6C_pd Subfamily PPP6C 25-284 3.4e-81 265.6 In-house 14-273 (290) alignment 
Range on Protein: 25-284
Range on HMM: 14-273/290.0
TLKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESA
 | |. ...| ..  ...  .  .  ...|| .|||||||| ||. .|.. |  |...|.||||.||||  ||||. .|.. |.||| .  |||||||| 
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

SINKIYGFYDEIKRRH-TVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLNHtTKGWGHNDRGVSFTF
 | ..|||||| ....  .  |. .|. |. |..||.. |...| |||||| .. |.||. |.| ..|| .| .|||.|.| ..  . |   .||  . |
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdped.vetwavsprgagylf

DKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTD
 . ....|..  .|.|..|||..||.|.... . .||||.||||||    |   .......
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaleda
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 40-295 3.6e-81 265.7 In-house 20-275 (280) alignment 
Range on Protein: 40-295
Range on HMM: 20-275/280.0
EVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESASINKIYGFYDEIKRR
 ..  .  | | .||... |||| |. |. |.|   |  |. . .||||||||| | .| . |||. |..|    .|||||||. |.||||||| |.. .
aifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqyk

HTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLNHTTKGWGHNDRGVSFTFDKVIVRDFLKAFDLQL
. | ||  |  ||| .|...|. .|..| |||||| | ||. |  | || .  | |.. ||||.|     .|| |. ||.|. | | .| .  |.....|
ygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqacksleidl

MVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVIILPC
..|||.||.||||..| |.|.|||| ||||  . ||  |. . ..|  ||  ..| 
iirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
PPP_2 55-247 1.4e-77 252.8 In-house 1-198 (198) alignment 
Range on Protein: 55-247
Range on HMM: 1-198/198.0
VNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESASINKIYGFYDEIK-RRHTVRLWHSFTDCFN
|..|||.|||..|||..|| ....|. .||||||||||||.|||...||.|.|..|| ...||||||||...||.|||..|.. .... .... ....|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

WLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLL----WADLNHTTKGWGHNDRGVSFTFDKVIVRDFLKAFDLQLMVRAHEVV
.||.|||. |.....|||||.....|.||....|....|.|| ..|||    . | ....... .. ||....| . .....|....|.|..|||||.
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHevk
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 48-294 5.9e-76 248.6 In-house 2-255 (263) alignment 
Range on Protein: 48-294
Range on HMM: 2-255/263.0
LLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESASINKIYGFYDEIKRRHTV-----
|||||||.||||| |||. ||||||.|||   |..||||||||||| .||| | |||. |.  | ...|||||||  .||| |||. |.|.|        
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

RLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPD-EGIMCDLLWADLNHTTKGWGHND-RGVSFTFDKVIVRDFLKAFDLQLM
 ..  | . |...|..|.| .||.| |||.|| |..|..|  |  | .      . ||||||| .. .||.  |  | .|  | |  | |. | .|..|.
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

VRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVIILP
||||.||| || |||.|.|.|||||  |   . |   |. |   |  ||| . |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp
subfamily_PPG1_pd Subfamily PPG1 26-284 1.1e-75 247.7 In-house 14-285 (300) alignment 
Range on Protein: 26-284
Range on HMM: 14-285/300.0
LKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESAS
| |  .. |... .|..  .  . |...|| . ||.|||| |.| |||  |  | .||||||||||||  |.||| || . |..||    ||||||||  
lpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrq

INKIYGFYDEIKRRH--TVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLN--------HT-TKG--W
| ..|||| |  |..    |.|. .|. |..| .||.. | |.| ||||||| . ..||. ..|  ..|.|| ..||||.| .        |   .|  .
itqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhf

GHNDRGVSFTFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTD
   .||  ... | .|  ||.  |.. ..|||... .||. . . .| ||.||||||    |   .. .   
vvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyek
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 27-288 3.3e-74 242.8 In-house 8-293 (302) alignment 
Range on Protein: 27-288
Range on HMM: 8-293/302.0
KEELIeRLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKA------------CGFPpKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNF
|.||.  ||..  | .| .  | |. .|| | ||||||| ||.||..|             .|  .  ..|||||||||..|.| |||.||.|| || |.
ksell.llieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfs.sdkfvflGdyvdrGsksieciclvfalkvlyptny

FLLRGNHESASINKIYGFYDEIKR----RHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRP-TDIPDEGIMCDLLWADLN---
 |||||||. .||  ||| .|..     ... ..|. | ..| ..|.||||||.|.| |||.|| |. |..|..|.|| ... .. .  |||.||     
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

------HTTKGWGHNDRGVSFTFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICS
      .. |    . ||.|..|..  |||. | ..|.|.|||| ..  |. |||...|.|.||||.|   ..| | |. | |.   |
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngkls
PPP_4 55-246 5.4e-74 241.5 In-house 1-196 (197) alignment 
Range on Protein: 55-246
Range on HMM: 1-196/197.0
VNICGDIHGQFTDL-LRIFKACGFPP-KANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESASINKIYGFYDEIKRRHTVRLWHSFTDCF
| ..||||||..|| |...|  |.|. . .|.||||||||||.|||...||.|.|..|| ...||||||||.|.|..|||..|....|. .... ..|.|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

NWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIP-DEGIMCDL-LWADLNHTTKGWGHNDRGVSFTFDKVIVRDFLKAFDLQLMVRAHEV
..||.|||. |.....|||||..|..|..|..|.|....| .|. ..|| ||.| .....|. .. ||....| . ....||.. .|.|..|.||.
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 27-285 6.6e-74 241.8 In-house 9-291 (302) alignment 
Range on Protein: 27-285
Range on HMM: 9-291/302.0
KEELIeRLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKA------------CGFPpKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNF
|.||.  ||..  | .| .  | |. .|| | ||||||| ||.||..|             .|  .  ..|||||||||..|.| |||.||.|| || |.
ksell.llieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfs.sdkfvflGdyvdrGsksieciclvfalkvlyptny

FLLRGNHESASINKIYGFYDEIKR----RHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRP-TDIPDEGIMCDLLWADLN---
 |||||||. .||  ||| .|..     ... ..|. | ..| ..|.||||||.|.| |||.|| |. |..|..|.|| ... .. .  |||.||     
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

------HTTKGWGHNDRGVSFTFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDL
      .. |    . ||.|..|..  |||. | ..|.|.|||| ..  |. |||...|.|.||||.|   ..| | |. | |. 
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 82-295 5.3e-71 232.5 In-house 121-334 (339) alignment 
Range on Protein: 82-295
Range on HMM: 121-334/339.0
NYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESASINKIYGFYDEIKRRHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQ
 |||||||||||  |.| . || | |. ||   .|||||||| |.|  |||| |.. |.  .|.  | . || .|..|.. . |.| |||.|  |  ..|
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

INHIQRPTDIPDEGIMCDLLWADLNHTTKGWGHNDRGVSFTFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSV
.  ..|| .||| |.. || ||| . | ||.    || || |    .| ||| .|||...| |.|||||||||  |.|||.||||||||  .|.  |.|.
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

STDLICSFVIILPC
   |  |  .. | 
dkklkisinvfrpe
PPP_5_Dcr2 55-247 2e-70 229.8 In-house 1-199 (199) alignment 
Range on Protein: 55-247
Range on HMM: 1-199/199.0
VNICGDIHGQFTDL-LRIFKACGFPP-KANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESASINKIYGFYDEIKRR-HTVRLWHSFTDC
| .|||.|||. || |..|| .|.|. . .|.||||||||||.|||...||.|.|..|| ...|||||||. ..|.||||..|.... |  .... ..|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIP-DEGIMCDL-LWADLNHTTKG-WGHNDRGVSFTFDKVIVRDFLKAFDLQLMVRAHEVV
|.|||.|||. |.....||||||..........|.|...|| ..| ..|| ||.| .....| . .. ||....| . ....||.  .|.|..|.||..
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 28-298 8.5e-70 228.3 In-house 22-295 (307) alignment 
Range on Protein: 28-298
Range on HMM: 22-295/307.0
EELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESASIN
 | .| .| ... ..  .  |.... |. . ||.|||| ||. .|   | ||.. |.| |||||||  |||.| |||.||. || |  ||||||| | .|
keefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvn

KIYGFYDEIKR---RHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWADLNHTTKGWGHNDRGVSFTFD
| ||||.|      .    .|  |  ||| ||..||.  .|.| ||||||.|  |...    .|   |  ||. |.|||| . .   |    ||  ||| 
kkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfg

KVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVIILPCHKY
  .. |  | . ..|..|||... |||  .. |.|.|.|||| || . .||| |. |   |    | ..|  . 
tnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpesen
subfamily_PPPLV_pd Subfamily PPPLV 36-279 2.6e-53 174.2 In-house 7-274 (290) alignment 
Range on Protein: 36-279
Range on HMM: 7-274/290.0
QQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRI----FKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESASINKIYG
... ...  .  ||||..|. . ||.||.. ||  .    ..       |..||||||||||. |.| |. |.| || ||  ..|||||||  |. . . 
dvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesie

FYDEIKRRHTVRL---WHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQR-----PTDIPDEGIMCDLLWADLNH-----------TTKGW
.. | . ..  .|   |..|...|..||.|| . ...||.|.|.  .     .|  ||      . ||    .  |.||.| ..           . .|.
ykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGf

GHND-RGVSFTFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVM
 .|| || .  | .  .  |||  .|. ..||||| | |...  . .|.||||. .|||  |.|  ..
vdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalil
Metallophos Calcineurin-like phosphoesterase 54-247 1.1e-41 136.3 Pfam-A 2-199 (200) alignment 
Range on Protein: 54-247
Range on HMM: 2-199/200.0
PVNICGDIHGQFTDL----LRIFKACGFPPKANYLFLGDYVDRGKQSLETICLL--FAYKVKYPLNFFLLRGNHESASINKIYGFYDEIK----------
.. ..||.||.. ||    |...|... ..  ..|||||.||||. |.||..||  ...|...| ..||||||||| ..|. |||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------RRHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQInhiqrptdipdegimcdllwadlnhttkgwg
                         ... . .  . ..|..|| .|||. .|...||.||.|. .  .|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

hndrgVSFTFDKVIVRDFLKAFDLQLMVRAHEVV
      |. | .  ....|.  ...| .|.|. .
.....gselfgpdalekllekygvdlvlrGHtHk
subfamily_PPP7C_pd Subfamily PPP7C 25-187 6.1e-41 133.4 In-house 32-201 (383) alignment 
Range on Protein: 25-187
Range on HMM: 32-201/383.0
TLKEELIERLIQQTREVIKWQPMLLELQA----PVNICGDIHGQFTDLLRIFKACGFPPKA-NYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRG
.|. . .  .......|.|  | . ....     | .|||.||.. ||| |.   |.| .  .|.| ||.|||||.|.| ...|.|. . || ...| ||
llhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrG

NHESASINKIYGFYDEIKRR---HTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSlRNLQQINHIQR
|||   .|  |||  |.. .   |. .. . . | | |||.|.|. |.|. .|||.| .  .|. ...|.|
nhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdk.tdlelldkier
subfamily_PPP7C_pd Subfamily PPP7C 197-293 1.9e-17 56.1 In-house 237-333 (383) alignment 
Range on Protein: 197-293
Range on HMM: 237-333/383.0
MCDLLWADLNHTTKGWGHNDRGVSFTFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQLVTVFSAPNYCGMMNNAGGVMSVSTDLICSFVIIL
. |.||.| ....  .    ||    |   . ...|. ..|.|..|.||   .||||  .....|.||| ||  .  | |  . ...||   .|   
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyq
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 27-78 7e-14 44.7 In-house 10-61 (317) alignment 
Range on Protein: 27-78
Range on HMM: 10-61/317.0
KEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFP
||. .  |  ..||..  .|. |||.||| |.||||||| ||| ...  |.|
kekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 29-78 4.9e-10 32.0 In-house 15-63 (339) alignment 
Range on Protein: 29-78
Range on HMM: 15-63/339.0
ELIErLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFP
|| | | ...||.|  .|..|.|.||. . ||||||| ||| ..   |.|
elae.lchrareliwsepiflkleapicvmgdihgqfddllamldmngwp
subfamily_YNL217W_pd Subfamily YNL217W 57-159 6.1e-08 25.4 In-house 14-107 (235) alignment 
Range on Protein: 57-159
Range on HMM: 14-107/235.0
ICGDIHGQFTDLLRIFK--ACGFPPKANYLFLGDYVDRGKQSLETICLLfaykvkYPLNFFLLRGNHESASINKIygfydEIKRRHTVRLWHSFTDCFNW
. ||.|| . .|.....  . |  . .  ...|| ...| .|.|.. ..         .   ..|||| . . ..     .. .. .    . |.. |..
vvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay.....kwvkkpkgaeplefsskfsf

LPVAA
|. . 
leskl