Gene mts in Drosophila melanogaster

Synonym: CG10930, D19, DmPpY-55A, Dmel\CG10930, PPY, PPY 55A, PpD19, Dmel_CG10930, PpY-55A

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP2C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP096_AA protein Get Run
DmelP096_AA_2-295 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP2C_pd Subfamily PPP2C 7-296 2.9e-192 630.1 In-house 1-290 (290) alignment 
Range on Protein: 7-296
Range on HMM: 1-290/290.0
TKDLDQWIEQLNECNQLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVR
.||||..||.|.||.||.|..|..||.||||||||||||||||||||||||||||||||.|||.||||||||||||.|||||||||||||||||||||||
ikdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvr

YRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSDPDDR
|.||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||.||.|||||||||||||||.|||||||||||
ykeritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddr

GGWGISPRGAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFDPAPRRG
|||||||||||||||.||||.||.||||||..||||||||||||.|||||||||||||||||||||||..||||.||.||||||||||||
ggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprrg
subfamily_PPP4C_pd Subfamily PPP4C 8-293 7.5e-150 491.0 In-house 1-286 (288) alignment 
Range on Protein: 8-293
Range on HMM: 1-286/288.0
KDLDQWIEQLNECNQLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRY
.|||. ||.|..|. ..|..|..|| ||.||| .|||||.|..|||||||.||||.||.|||..||. |.|||||.||.||||.|||||  ||.||||||
sdldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvry

RERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSDPDDRG
 .|||..||||||||||||||||||||||||.||||.| |..||||.|.|..||.|||.||||||||..||.||..|| ||||||||.||||||||.|  
pdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae

GWGISPRGAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFDPAP
||..||||||| ||.|..|.||..|...|..||||||||||..  ...|.|..||||||||||| ||..|||..|.  |  |. |.
gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaa
subfamily_PPP6C_pd Subfamily PPP6C 9-290 1e-137 451.1 In-house 1-282 (290) alignment 
Range on Protein: 9-290
Range on HMM: 1-282/290.0
DLDQWIEQLNECNQLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYR
.||.|||. ..|. |.|.... |||. ...|..||||| |..|||||||.||||.||.|||| ||. |||.|.|.||.|||||||.||.|.|..||..| 
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

ERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGG
.|||.|||||||||||||||||||||.||||||.|||.|..|| |...|..|.|..|.|||||| .  ||.|| ..| ||.||.|..|||.||||.|   
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WGISPRGAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFD
| .||||||| ||. ... |...| | |..||||||.||...  | ..||..||||||||||| |....|.|. . ..  |.
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk
subfamily_PPG1_pd Subfamily PPG1 10-294 2.6e-131 430.3 In-house 1-298 (300) alignment 
Range on Protein: 10-294
Range on HMM: 1-298/300.0
LDQWIEQLNECNQLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRE
||. .|.|. .. | |. |. |.|| ||.| |||||.|...|||| |||||||.|..|.|.|||. |||||||.|||||||.|||||..||..||.||  
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RITILRGNHESRQITQVYGFYDECLRKY-GNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSDPD----
|||.||||||||||||||||| |||||| ||..||||.|..|||| |.|..| .|.|.|||||||. |.| |. |||..|||.|| ..|||||||.    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DRGG--WGISPRGAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFDPAPR
      || |  . .|.|||||..|.|. | | ..| .  . |||||..|||.   |  . |..|||||||||||.|...|| . ... |  .. ||.
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeape
0045823 Metallo-dependent phosphatases 5-294 9.8e-122 399.8 In-house 25-326 (473) alignment 
Range on Protein: 5-294
Range on HMM: 25-326/473.0
ATTKDLDQWIEQLNECNQLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALK
 .  |||..||.| ....|.|.... |.|.|||||.||.|..|.. ...|.||.|||..||..|... |  |.....|.||.||||..|.|.. || |||
lglldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalk

VRYRERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSDPD
..| .....||||||.|.....|||.||.|.|| .......| .....|||.|...|.|.. ||||||....|| ||...| .|.|..|...|||||||.
ikypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPw

DRGG--------WGISPRGAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRN------VVTIFSAPNYCYRCGNQAALMELDDSLkFSFLQFD
.  |        .| |||||||.||.|. | | . |||.|. |.|. |.|||....|..      ..|.|||||||.|.|| ||....|. | .|| |||
eddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfd

PAPR
|.| 
psph
PPP_3 23-289 8e-119 388.6 In-house 2-269 (271) alignment 
Range on Protein: 23-289
Range on HMM: 2-269/271.0
LTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQ
|.|.....|..|.||||.||||..|.. |||||||.|||..||.|||..||.||.|.|||.|||||||..|.|...||.|||..| .....|||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDL-LWSDPDDRGGWGISPRGAGYTFG
|..||||..|.|.|.|...|.|.....|..|||.||.|......||||||||.|||.|. |.| .|||.||...|| |.|||....|.. |.||||..||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

QDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQF
.|..|.|...| |.|. |||.|..|||. .||..|||.|||||||.|..|..|...|...|. .| |.
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
PPP_1 24-278 3.2e-117 383.5 In-house 2-264 (264) alignment 
Range on Protein: 24-278
Range on HMM: 2-264/264.0
TETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQI
.|.....|..|.||.|.||.|..||. ..|||||.||||.||..||..||.||.|||||.|||||||..|||...||.|||..|......|||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDL--------LWSDPDDRGGWGISPRG
|.||||..|.|.|.......|..||.||.|||.||.|..|...||||||..|.||.|| ..| .|||.||..|||        |..|.......  |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMEL
|||.||.|..|.|...|.|.|. |||....|||.....|.|||||||.||.....|..|...|
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
0049330 Metallo-dependent phosphatases 3-295 6e-114 373.2 In-house 10-302 (309) alignment 
Range on Protein: 3-295
Range on HMM: 10-302/309.0
DKATTKDLDQWIEQLNECNQLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVA
.. ....||..||.|  . .|.| ....|..|||||| .|.|..|.. ...|.||.|||..||..|... |  |.....|.||.||||..|.|...|| |
lelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevllllla

LKVRYRERITILRGNHESRQITQVYGFYDECLRKYGnANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSD
||..|......||||||.|.....|||.||.||||| |..|..|.|....|||.|...|.|.| ||||||.. .||.||.|.| .|.|..|..|||||||
lkllypdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsd

PD-DRGGWGISPRGAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFDPAPRR
|. .| |.. .|||.|..|| .. | | ..|||.|. |.|..|..|| ...|....|.|||||||.|.||..|..|.|..|..|||.|.|.|. 
plpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
0053225 Metallo-dependent phosphatases 4-293 1e-109 359.4 In-house 3-292 (293) alignment 
Range on Protein: 4-293
Range on HMM: 3-292/293.0
KATTKDLDQWIEQLNECNQLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVAL
. .. .||..||.|  . .|.|.....|...|||||.||.|..|.. ...|.||.||...||..|... |  |.....|.||.||||..|.|...|| ||
slilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllal

KVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSDP
|..|......||||||.......|||.||.|||||.|..|....|....|||.||..|.|.. ||||||....||.|| ..| ...|.||...|||||||
kllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdp

DDRGGWGISPRGAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFDPAP
|.. ||..|.||.|..|| .. . | ..|||.|. |.||.|..|| ...|...||.||||||..|.||..|...||..|...| .|.| .
dlwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
PP2Ac_SM00156 24-292 1e-109 358.8 In-house 2-270 (271) alignment 
Range on Protein: 24-292
Range on HMM: 2-270/271.0
TETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQI
.. .|..|....||||..|.|. ||. ||||.||.|||..||..|.. .|..|...|.|.|||||||..|.|...||.|||..| |....|||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSDP-DDRGGWGISPRGAGYTFGQ
...|||..|. ||| ...... |...|..|||.|||| .|.|.||||||.. |||.|| |.| .| |.||...||||||| ..  |. .| ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFDPA
|. . | ..| | |. |||..|.|||....|...||||||||||....|.|| ......|| |. |....
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
subfamily_PPP1C_pd Subfamily PPP1C 20-290 6.3e-107 349.9 In-house 7-277 (282) alignment 
Range on Protein: 20-290
Range on HMM: 7-277/282.0
CNQLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHE
  .|.|.....|..||.||| ... . |.. ||...||.|||..||. || ..|  |..||||.|||||||  |.||..||.|.|..| |.. .||||||
evklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhe

SRQITQVYGFYDECLRKYGNAnVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGY
| .|...||||||| |.|..  .|| ||| |..|||.|||| .|.|.||||||...||..|| . |  |||..| .|||||||||. . ||. . ||  .
sasinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsf

TFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFD
|||.|. |.| . | | |. ||||.| .||..  .|..||.||||||| . .|..|....|..|. ||  . 
tfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilk
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 10-293 7.9e-100 326.7 In-house 11-295 (298) alignment 
Range on Protein: 10-293
Range on HMM: 11-295/298.0
LDQWIEQLNECNQLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRE
| . ... . .....|..| .|...||.|..| . . ||. |..||||.|||. ||. ||  .|  ||.||||.||||||| ...|...||.| ||.| .
lsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypn

RITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSDPDD-RGG
.. .||||||  .| .|||||.|| |.| . .... | |.|. ||||||. |.|.|.|||||. . |||..|.| | .. ..|    ||||.||..   |
nffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkg

WGISPRGAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFDPAP
|  . ||....||.|  . . ..  . || ||||.| .||..  ....|||||||.|| .  | ||.|..|. |. ||  . |. 
waensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 22-295 1.7e-89 293.0 In-house 23-297 (299) alignment 
Range on Protein: 22-295
Range on HMM: 23-297/299.0
QLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESR
 . | ...|||. ||... ... . ||. |. ||||.|||. ||. .| . |  ||.|.||.|||||||   .|..|||.. |..| ||. .||||||  
svkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecp

QITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTF
 | .|||||.|| ..|  . .|  | | |...||| |. ..|.|.|||||| ...|| .| | | |. |      ||||.|||.   .|    ||  | |
ainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvf

GQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFDPAPRR
|||. .   .. .. ||.||||.| .||..  ....||||||| || .  | ||.|..|. |  .|  . |.|..
gqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpks
subfamily_PPP3C_pd Subfamily PPP3C 11-281 2.2e-88 290.0 In-house 29-312 (452) alignment 
Range on Protein: 11-281
Range on HMM: 29-312/452.0
DQWIEQLNECNQLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRER
.   | . .  .|.|...  . ..| ..|.||... ||. |.||.||.||||.||..|| .||.  .|.|||.||||||||.|.|.|  | |||. | ..
evlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypst

ITILRGNHESRQITQVYGFYDECLRKYGNaNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWG
. .||||||.| .|. . | .||  ||.. .|.. ... || |||.||...| .|.|||||| | ||| |. |||..|.|. ||.|||||||| .. |  
lfllrGnhecrhlteyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygee

I--------SPRGAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHD------RNVVTIFSAPNYCYRCGNQAALMELDDS
         |.||  | ..   . .| ..| |  . |||.   .||.  ..        ..|.||||||.    |.||...... 
kteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 19-292 2.7e-87 285.5 In-house 4-275 (280) alignment 
Range on Protein: 19-292
Range on HMM: 4-275/280.0
ECnqLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNH
.|  . |... .. .| |.||. .. . ||..||.||||.|||. ||. ||   .  ||.||||.||||||| . .| . ||.| |||| ... ||||||
ac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnh

ESRQITQVYGFYDECLRKYGNaNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSDPD-DRGGWGISPRGAG
|  .| . |||.||. |.| . .... | .|.| |||.||| |.|.|.|||||. . |||... | |  . ..|    ||||.||. .  ||. ..||. 
evisinrkygfkdevkrrysl.alynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvs

YTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFDPA
. ||...   . .   . |. | ||.| .||..  |...||.||||.|.    |.||.. .|. |. ||  . ||
vifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 20-290 4e-84 275.4 In-house 4-281 (284) alignment 
Range on Protein: 20-290
Range on HMM: 4-281/284.0
CNQ-LTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKS------PDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERIT
|.. |.|...  || .|.|.. ||.  .|...||...||.|||| ||. |. . |         ...|||.||||||| .|.| .||| |.|... ....
cqkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvf

ILRGNHESRQITQVYGFYDECLRKYGNAnVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGI
.|||||||| . . |||| || ..| .| ... |   |  .||.|.|. .|.|.|||.|  . .|. . .|.|  ..|  | ..|| |.||. .  |.  
llrgnhesrpvnmqygfyleckkrysea.lyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegyke

SPRGAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFD
|||||| .||..  . |...  | || ||||.||.||..  ||..||||||| || .  | ||....|. |  ||  . 
sprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk
subfamily_PPP5C_pd Subfamily PPP5C 3-291 6.7e-84 274.6 In-house 14-308 (322) alignment 
Range on Protein: 3-291
Range on HMM: 14-308/322.0
DKATTKDLDQWIEQLNECNQLTETQVRTLCDKAKEILSKESNVQEVKCP----VTVCGDVHGQFHDLMELFRIGGK-SPDTNYLFMGDYVDRGYYSVETV
.| |.. ... .|.... ..| .  . ..  .|||.|.|.. . |.. .    .|||||.||||.||...|.. |. |..  ||| ||.|||| .|||..
ekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsvevi

TLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSID-SLDHIRALDRLQEVPHEGPMC
 .|...|. | ... . |||||| .. ..||| .|.  || ...| . ||..|..|||. ... ... .||||  . . .||..| .|| .. |.|| ..
ltllgfkllyPnhfflsrGnhesdnmnklyGfegevkaky.tekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllv

DLLWSDPDDRGGWGISPRGAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMEL-DDSLKFSFLQFDP
.||||||... | . | || | .|| |... | ..|.|.|. |.|.. .|||.  || ...|.||||||| . ||..|...| .| ||  | .|. 
ellwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfea
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 22-294 4.3e-83 271.8 In-house 7-279 (281) alignment 
Range on Protein: 22-294
Range on HMM: 7-279/281.0
QLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESR
|.|. .. ..  ... |.|.|... |.. |..| ||.|.||.|| .|| . |. |.. ..|.|||||||  |.|.. || .||.|||.|| .||||||  
qytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheia

QITQVYGFYDECLRKYGNaNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGYTF
.. ..|||| ||  |||  ..|  |   |. ||..||.. .. |.|||||| . .||..|   .  . .. | . ||||.|||... .|  | ||...||
svnkiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftf

GQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFDPAPR
|... .    . .. |. ||||.|..||.    |...|.||.||||    | ||.. .|..|. |.... ||. 
GknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpase
subfamily_PPZ_pd Subfamily PPZ 23-291 1.4e-82 270.5 In-house 25-293 (300) alignment 
Range on Protein: 23-291
Range on HMM: 25-293/300.0
LTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQ
| ....  .| ||.|..  . .. |.  .| . ||||||. ||. ||   |  | .||||.|||||||  |.||. ||.. |..| | . .||||||  .
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecan

ITQVYGFYDECLRKyGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFG
.|.|||||||| |.  | ..|| | | |. |||.|.| |.|||.|||||| ..|.| || . |  .||  | . ||||||| |    |    ||  | . 
vtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycyn

QDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFDP
.   . | |  |. || ||| .| .||..  ||..||.|||||||    |  |.| . . |  ||  .||
kvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
PPP_2 52-243 2.7e-80 261.7 In-house 1-197 (198) alignment 
Range on Protein: 52-243
Range on HMM: 1-197/198.0
VTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFD
||||||.|||..||..||. |..||...|||.|||||||..|.|...||.|||..|......|||||||.....||||..|.|.|.|...|.|.....|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDL-----LWSDPDDRGGWGISPRGAGYTFGQDISETFNNTNGLTLVSRAHQL
.|||.||.|......|||||..|..||.|.  .| .|.|.||...||     |..........  | ||||..||.|..|.. ..| |.|. |||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 20-291 4.3e-78 255.1 In-house 7-281 (287) alignment 
Range on Protein: 20-291
Range on HMM: 7-281/287.0
CNQLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHE
 . ...... .. .|..|||   . . ||. |.|..||.|||..||. .|   |..|...|||.|||||||  |.| . || .||..| ... .||||||
ldafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhe

SRQITQVYGFYDECLRKYGnANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQE--VPHEGPMCDLLWSDPDDRgGWGIS---PR
 ..| ..|||..|  ||..  ...| | |.|..||| | |. .|.|.|||.|| ..||| ..|| . .     .|| . ||||.||.     ..     |
vkkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd.aktfelnkir

GAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFDP
.    ||.   . . .. .. |. |||... |||..  |...||.|||| |. .  | .|.. ...||..|| .. |
aisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 20-290 7.2e-78 254.8 In-house 20-293 (297) alignment 
Range on Protein: 20-290
Range on HMM: 20-293/297.0
CNQLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHE
.. .|| .|  | | | ... .. .. ||..|. ||||.|||| ||. ||. ||  | .||||.||||||| .|.||. ||.| ||..   . .||||||
skviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhe

SRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSP---SIDSLDHIRALDRLQEVpHEGPMCDLLWSDPD-DRGGWGISPRG
   . .|||||.|| ..|    ..  | |.|..|||| |.  .|.|.||||||      .|| .| ..| .|  .|. ..||||.||     |.    ||
cefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqrg

AGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFD
||  ||.|          | || ||||.| .||..   |..||||||| || .  | ||.|  |. |. ||  . 
agcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilr
PPP_4 52-243 6.6e-76 247.7 In-house 1-196 (197) alignment 
Range on Protein: 52-243
Range on HMM: 1-196/197.0
VTVCGDVHGQFHDL-MELFRIGGKSP-DTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKyGNANVWKYFTDL
|||.||.|||..|| ..|...||. . ...|.|.|||||||..|.|...||.|||..| .....|||||||......|||..|.|.|  .....|...|.
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVP-HEGPMCDL-LWSDPD-DRGGWGISPRGAGYTFGQDISETFNNTNGLTLVSRAHQL
||.|||.||.|......|||||....|||.|....| .|.| .|. ..|| |||||  .  |.  | ||||..||.|. |.| ..|.| |. |.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 52-243 3.7e-75 245.3 In-house 1-198 (199) alignment 
Range on Protein: 52-243
Range on HMM: 1-198/199.0
VTVCGDVHGQFHDL-MELFRIG-GKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDL
||||||.|||..|| ..||. |  .|....|.|.|||||||..|.|...||.|||..| .....||||||..|....|||..|.|.||......|...|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVP-HEGPMCDL-LWSDPD-DRGG-WGISPRGAGYTFGQDISETFNNTNGLTLVSRAHQL
||.|||.||.|......||||||.|.|........| .|.| ..| ..|| |||||  .  | .  | ||||..||.|. |.| ..|.| |. |.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 18-293 1.2e-73 241.0 In-house 1-276 (280) alignment 
Range on Protein: 18-293
Range on HMM: 1-276/280.0
NECNQLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGN
| || .|  .. ..    . |. .|||. | ..|. | ||.| |..|.  || . |. |. . .|.|||||||   .| . ||..||.|||.|| .||||
nicnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgn

HESRQITQVYGFYDECLRKYGNAnVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSDPDDRG-GWGISPRGA
||.  . ..|||| ||  ||| . .|  |   |. .|...|.  ...|.|||||| .  || || . |  |    | . ||||||| ..| ||  | || 
hetpsvnkiygfyvecqykygvg.lwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgi

GYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFDPAP
 | ||. . |   ..  . |. ||||.| .||.    | ..|.|| |||| .  | ||.. |.  |. || |. | |
symfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlippp
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 77-292 3.5e-73 239.5 In-house 100-315 (317) alignment 
Range on Protein: 77-292
Range on HMM: 100-315/317.0
DTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDS
  .|||.||||||| .|.| |.||.|||..| .....|||||||| . . |||| |. ..| .|.... |   |  |||.|.|. .|.|.|||.| .. .
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelld

LDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAL
|. . .|.|  ..|  | ..|| |.||| .  |.  |.||||  ||..  . |...  | || ||||.|..||..  ||..|||||||.|| .  | ||.
lkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav

MELDDSLKFSFLQFDPA
...|. || |.  . | 
lsvdkklkisinvlrpe
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 26-291 6.9e-73 238.5 In-house 6-273 (284) alignment 
Range on Protein: 26-291
Range on HMM: 6-273/284.0
TQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQ
 .| ||  .| .|. |.  . ||. |. .|||.|||| ||. ||   |    .||||.||||||| . .||. ||.| || . ... .||||||   | .
edvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

VYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPM-CDLLWSDPDD-RGGWGISPRGAGYTFGQD
.||||.|| |.| .  |.. |  .|  .||||||  .|.|.|||.|  .. . ..||. |  . |    .  |.||||| . . ||    ||  | || |
iygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsd

ISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFDP
    . .   . || ||||.| .||..  .| .||||||| || .  | ||.| ..  |  ||. . |
alrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrp
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 17-291 1e-69 227.7 In-house 10-288 (290) alignment 
Range on Protein: 17-291
Range on HMM: 10-288/290.0
LNECNQLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRG
    . ... .. .. .|..|||     . ||. |... ||.|||. .|.. |   |. |. ..||.|||||||  |.|   ||  .|.|| ... .|||
ygvldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrg

NHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDR--LQEVPHEGPMCDLLWSDPDD--RGGWGI-
||| |.. ..|||..|  ||  ....|| . |.|. |.| | |. .|.|.|||.|. |.| . ..|| .   .   .|| . ||||.||.        . 
nhevrkvnrlygfkeelarkr.gsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialn

SPRGAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFDP
  |.    ||..  ... .. .| |. |||..  ||.|.  |...||.|||| |. .  |  |.... .||..|.  . |
kqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkp
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 23-293 1.2e-66 218.0 In-house 20-293 (307) alignment 
Range on Protein: 23-293
Range on HMM: 20-293/307.0
LTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQ
 |  ..  .  .|. |.| |  . ..  |. | ||.|||| ||...| . |. |.| |.| |||||||  |.|.. ||.. |. | | | .||||||  .
ytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiar

ITQVYGFYDECLRKYGN--ANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYT
. . ||||.||.    .   ..|  |   |. ||..||.  .|.|.||||||..  || .|   .    |  | . |.||.|||     |  | ||.|.|
vnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgft

FGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFDPAP
|| .. .   .  |. |. ||||....||     |...|||||| ||    |  ... .|..|    . | |. 
fgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpes
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 21-286 4.1e-59 193.2 In-house 4-294 (302) alignment 
Range on Protein: 21-286
Range on HMM: 4-294/302.0
NQLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSP-----------DTNYLFMGDYVDRGYYSVETVTLLVALKVRYRE
........ .|...  | |.||... |.  |||. ||.||||.||. ..    ..               ..|.|||||||. |.| ..|. |||| |..
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlypt

RITILRGNHESRQITQVYGFYDECLRKYGNAN---VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDR-LQEVPHEGPMCDLLWSDPDD
.  .||||||.. |   ||| .|   ..|...   .|. | . | ..||.|||  .|.|.|||.|| ..||..|. ..| |.|| ..    |||..|| |
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

RGGWGISPRGAGYTFG--QDISETFNNT--------NGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSF
  .  . ..   |..   ...| .||..         .| |. |||| . ||...  |....||||||.|     |. | ...|   |.| 
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsi
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 21-286 6.5e-59 192.6 In-house 5-295 (302) alignment 
Range on Protein: 21-286
Range on HMM: 5-295/302.0
NQLTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSP-----------DTNYLFMGDYVDRGYYSVETVTLLVALKVRYRE
........ .|...  | |.||... |.  |||. ||.||||.||. ..    ..               ..|.|||||||. |.| ..|. |||| |..
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlypt

RITILRGNHESRQITQVYGFYDECLRKYGNAN---VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDR-LQEVPHEGPMCDLLWSDPDD
.  .||||||.. |   ||| .|   ..|...   .|. | . | ..||.|||  .|.|.|||.|| ..||..|. ..| |.|| ..    |||..|| |
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

RGGWGISPRGAGYTFG--QDISETFNNT--------NGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSF
  .  . ..   |..   ...| .||..         .| |. |||| . ||...  |....||||||.|     |. | ...|   |.| 
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsi
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 46-291 1.6e-58 191.4 In-house 3-255 (263) alignment 
Range on Protein: 46-291
Range on HMM: 3-255/263.0
QEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNAN----
 |...|. .||| |||. ||. .|   | .  |.|||.||||||| .|.| . ||..||.    .. .|||||| . | . |||. |  ...   .    
lelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyes

VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRALDRLQEVPHEGPM-CDLLWSDPDDrGGWGISP---RGAGYTFGQDISETFNNTNGLTLV
|...| ..| |.|| |.|  .|.|.|||.|| . ||| |||.    |  .  |. |||||.||.     |. |   |     ||.   . . .   . |.
vynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.dakgfepnkiraisnvfgkkevddlckrldidli

SRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFDP
 ||||.|  || .  || ..|.|||  |     | ||.. ..  |..||.|. |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 79-294 5.1e-58 189.8 In-house 121-336 (339) alignment 
Range on Protein: 79-294
Range on HMM: 121-336/339.0
NYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLD
 |||.||||||| .|.| | || |||. | .|| .|||||||| .   |||| |   .| .|.... | ..|. .|. |...  |.|.|||.|  . |..
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

HIRALDRLQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALME
..  . |  |.|  | . || |.|||    |.  | ||| . ||     .| .   | .| | ||.| .||..   | .|||||||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LDDSLKFSFLQFDPAPR
.|  || |   | |  |
idkklkisinvfrpesr
subfamily_PPPLV_pd Subfamily PPPLV 29-280 1e-53 175.6 In-house 3-277 (290) alignment 
Range on Protein: 29-280
Range on HMM: 3-277/290.0
RTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLM----ELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQIT
 .|||.| .|| .| .. |.| |. | ||.||...||.     |.|.| .   ...||.||||||| .||| .. |.|||| |  .. .|||||| . ..
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

QVYGFYDECLRKYGNA--NVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIRAL----DRLQEVPHEGPM-CDLLWSDPDDR-----------
. . .. |.  |.|.   .||. |.. ||.|||.| .| ..|| |.|.  .| .  .| |.    .||..  .  |.  |.|||||..            
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

--GGWGISPRGAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRcGNQAALMELDD
  |    . || |. |..|  |.| . |.|  | |||.   .|..  ..  ..|.||. .||    |.|||. .| 
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvdk
Metallophos Calcineurin-like phosphoesterase 51-243 2.6e-43 141.6 Pfam-A 2-198 (200) alignment 
Range on Protein: 51-243
Range on HMM: 2-198/200.0
PVTVCGDVHGQFHDL----MELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLL--VALKVRYRERITILRGNHESRQITQVYGFYDECL----------
...|.||.||...||    ..|..|..... ...||.||.|||| .| ||  ||   .||...  ..  |||||||......|||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDSLDHIraldrlqevphegpmcdllwsdpddrggwgi
                       ..... ... .. . |..||| |||||.|.. ||.||.| .| | |                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGYTFGQDISETFNNTNGLTLVSRAHQL
    ... || |  | . . .|..|| |.|. 
....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 7-186 2e-38 125.1 In-house 17-202 (383) alignment 
Range on Protein: 7-186
Range on HMM: 17-202/383.0
TKDLDQWIEQLNECNQLTETQVRTLCDKAKEILSKESNVQEVKC----PVTVCGDVHGQFHDLMELF-RIGGKSPDTNYLFMGDYVDRGYYSVETVTLLV
...... ||...| ..|    | ..  .||..| .  |...|.      ||||||.||.. ||. .. . |  |.. .|.| ||.||||  ||| . .|.
kdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillill

ALKVRYRERITILRGNHESRQITQVYGFYDECLRKY--GNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDsLDHIRALDRL
|| . | . . . |||||   .   |||  |   ||   .... . . |.| .|||..|.| .|. .|||.| . | |. .  ..| 
alllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktd.lelldkiers
subfamily_PPP7C_pd Subfamily PPP7C 195-292 3.9e-22 71.5 In-house 237-335 (383) alignment 
Range on Protein: 195-292
Range on HMM: 237-335/383.0
MCDLLWSDPDD-RGGWGISPRGAGYTFGQDISETFNNTNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAALMELDDSLKFSFLQFDPA
. |.|||||   .| .  . ||.|  || |... . .  .|.|. |.|.  .|||...||..|.||||| ||     |. | . | ..|.  ..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 20-73 8.3e-13 41.2 In-house 5-59 (317) alignment 
Range on Protein: 20-73
Range on HMM: 5-59/317.0
CNQ-LTETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGG
|.. ..|...  || .|.|.. ||    |...|||..||.||||.||. |. . |
cqdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_YNL217W_pd Subfamily YNL217W 52-125 2.4e-09 30.0 In-house 12-81 (235) alignment 
Range on Protein: 52-125
Range on HMM: 12-81/235.0
VTVCGDVHGQFHDLMELFR--IGGKSPDTNYLFMGDYVDRGYYSVETVTLLvalkvrYRERITILRGNHESRQITQ
. | ||||| . .|.||.   |||| ..   ...|| ...|  |||.| ..       ..    ..||||   . .
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvlla
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 25-73 1.2e-07 24.1 In-house 13-61 (339) alignment 
Range on Protein: 25-73
Range on HMM: 13-61/339.0
ETQVRTLCDKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGG
 ...  || .|.|..  |  . ....|. | ||.|||| ||. .. . |
aaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmng