Gene CanA1 in Drosophila melanogaster

Synonym: CG9819, CnnA14D, CnnA14D(I), D27, DmCanA-14F, Dmel\CG9819, PP2B, PpD27, canA-14F, Dmel_CG9819, CanA-14F

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP3C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP098_AA protein Get Run
DmelP098_AA_122-325 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP3C_pd Subfamily PPP3C 54-543 3.9e-253 833.1 In-house 1-452 (452) alignment 
Range on Protein: 54-543
Range on HMM: 1-452/452.0
RMVDDVPLPPTHKLTMSEVYDDpkTGKPNFDALRQHFLLEGRIEEAVALRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRY
|.|..||||...|||..||.|.  ||||....|..||| |||.||..||.||.|.|.||..||....|||||||.|||||||.||.||||||| ||.|.|
rvvkkvplpkskklteeevfde..tgkpklevlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastky

LFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIK
||||||||||||||||||||..|||.||.|| ||||||||||||||||||.|| |||||..||||||.||.|||||||||||||.|||||||| .|||||
lflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddik

TLNRFREPPAYGPMCDLLWSDPLEDFGNEKTNEFFSHNSVRGCSYFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQVTGFPSLITIFSAPNYLD
.|.||.||||.||.|||||||||||.|.|||.|.|..|||||||||.||.|.|||||||.||||.|||||||||||||||...||||||||.||||||||
kldrfkeppasGplcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyld

VYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDDELVAGPDDEleeelrkkivlvpanasnnnnnnntpSKP
||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||..  ..|                          || 
vynnkaavlkyennvmnirqfnssphpywlpnfmdvftwslpfvgekvtemlvnilnicsddelekeeeee..........................ske

ASMSALRKEIIRNKIRAIGKMSRVFSILREESESVLQLKGLTpTGALPVGALSGGRDSLkealqgltaSSHIHSFAEAKGLDAVNERMPP
.|.|. |||.||||||||||..||||.|||||||||.||||| ||||| ||||.|...|         .....||.|||.||..||..||
esesekrkevirnkiraigklarvfsvlreesesvlllkglt.tgalprgalsegkegl.........eeklssfeeakkldlineklpp
0045823 Metallo-dependent phosphatases 53-541 7.3e-153 502.4 In-house 2-448 (473) alignment 
Range on Protein: 53-541
Range on HMM: 2-448/473.0
ERMVDDVPLPPTHKLTMSEVYDdpKTGKPNFDALRQHFLLEGRIEEAVALRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTR
.|... |. |....||......    |....|.|..|.. ||...| ..|....| . .|..|.|.......|.|.||||||..|| .|.|  | |  .|
drvlklvlipvlrlltlpllfi..llglldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedr

YLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDI
..||||.||||..|.|....|..||| ||.   |||||||.|.|. .. |..|.. ||.|..|....| ...|||||......|..||||||.. .||.|
lvflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqi

KTLNRFREPPAYGPMCDLLWSDPLEDFGNEKTNEFFSHNSVRGCSYFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQVTGFPSLITIFSAPNYL
....|..|.| .|...||||||| ||.|...... | .||.||..|.|.. | .|||.||.|  |||.|.... ||.......|.|....||.||||||.
reierpleipddgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYc

DVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDDELVAGPDDEleeelrkkivlvpanasnnnnnnntpsk
....|.||||..........||..||||..||.|.|||..||||..||.||.|...|||.|||||   .|                              
grggnlaAvlvidedlisfiqfdpsphplilplfldvfllslpfllekltellllllnivsddellededil............................

PASMSALRKEIIRNKIRAIGKMSRVFSILREESESVLQLKGLTPTGALPVGALSGGRDSLkealqgltasshIHSFAEAKGLDAVNERM
.. ..  ..|..||||.|.||..||||.|||||||||.||||||.| ||.|.|. |.. |            ..|..||. || .||..
glllleallellrnkilalgkllrvfsvlreesesvlllkgltpsgllplgllllgkell............lesleealkldlinekl
PPP_1 98-362 6.9e-104 339.8 In-house 3-262 (264) alignment 
Range on Protein: 98-362
Range on HMM: 3-262/264.0
EAVALRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLT
|... ..... . ||..|.|...|...|||||||||||.||.|||.||||...|.|||||||||||..|.|..|.|..||. || .| |||||||.|..|
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

EYFTFKQECI-IKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFGNEKTNEFFSHNSVRGC
....||.|.   |||..||......||.||||||.....|..|||||||. .||.|....|..| |. |..||||..|  ... ..|..| . .||.||.
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

SYFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQVtgfpslITIFSAPNYLDVYNNKAAVL
.|.|.... ..||||||| .|.||||....||....|..|      .|||||.|| .. .|..|..
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkv......vtifsasnyyeegsnrgayv
PP2Ac_SM00156 98-369 2e-101 331.6 In-house 3-261 (271) alignment 
Range on Protein: 98-369
Range on HMM: 3-261/271.0
EAVALRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLT
.  .|... | ...|..|||...|.||.||.||||||. ||..|.| .|.|....|.|||||||||..|||..|.|..||| ||... |||||||.....
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn

EYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPledfgnEKTNEFFSHNSvRGCS
....|..|. .||...||. ..|||..||||||.....||.|||||||. .||||. |.|..|.|  |...|||||||      |.... |.... ||.|
kiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdp......eqkekgfqpsk.rgls

YFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNqvtgfpSLITIFSAPNYLDVYNNKAAVLKYENNVM
..|. .| .|||.||||  |.||||..| ||... ..      .|.||||||||.| ..|||||||.|.|..
vvFgedavkeflkknnlkliiRahevvdeGyeffadk......klvtifsapnycdefsnkaavlkveknlk
0049330 Metallo-dependent phosphatases 80-383 1.6e-96 316.0 In-house 14-305 (309) alignment 
Range on Protein: 80-383
Range on HMM: 14-305/309.0
KPNFDALRQHFLLEGRIEEAVALRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKIT
....|.|....| .....| ..|.....   .|..|.|.......|.|.||||||..|| .|.|  | |  .|..||||.||||..|.|..|.|..||. 
lslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkll

YPTTLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDF
||    |||||||.|.|. .. |..|.. ||.......... ...|||||......||.||||||.. .||.|. |.|..|.|..|..|||||||||...
ypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpir

GNektneffSHNSVRGCSYFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQvtgfpsLITIFSAPNYLDVYNNKAAVLKYENN-VMNIRQFNCSP
 .        ....||....| . | ..||.||.|  |.|.|.|.. ||... ...      |||.||||||.....|..|||..... |.....|...|
eg.......fapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgk......litvfsapnycgrlgnlgavleidedlvisfllfepvp

HPYWL
....|
lllll
PPP_3 96-369 8.2e-95 309.9 In-house 2-263 (271) alignment 
Range on Protein: 96-369
Range on HMM: 2-263/271.0
IEEAVALRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRH
..| .. ..... . .| .|.|.....||.|||||||||. ||..||..|||...|.|||||||||||..|.|..|.|..|||.||... |||||||.|.
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

LTEYFTFKQECI-IKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPLedfgnekTNEFFSHNSVR
......||.|..  |.....|....| |..||||||.....|..||||||.| .||.||.|.|..| |  |...|||.|..        ..| . .||.|
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdp.......ekeeglenskr

GCSYFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKnqvtgfPSLITIFSAPNYLDVYNNKAAVLKYENNVM
|....|. .. .|||.||.|  |.||||....||.....       ...|.||||||.. ..|..|.|| |.. .
GagllFgpdvteefleknkLkliiRaHelkeeGyeilhd......gkvvtvfSapnycerasnagailkleealt
0053225 Metallo-dependent phosphatases 80-375 2.5e-89 292.5 In-house 6-289 (293) alignment 
Range on Protein: 80-375
Range on HMM: 6-289/293.0
KPNFDALRQHFLLEGRIEEAVALRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKIT
....|.|....||  .. | ..|....|   .|..|.|.......|.|.|||||...|| .|.|  | | ..|..||||.||||..|.|....|..||. 
lllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkll

YPTTLSLLRGNHECRHLTEYFTFKQECIIKY-SESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPLED
||.   |||||||...|. .. |..|.. || .....|.... ...||||||.....|..||||||.. .||.|. .||. ..| .|...||||||| . 
ypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlw

FGNEKTNeffshnsvRGCSYFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKnqvtgfPSLITIFSAPNYLDVYNNKAAVLKYENN-VMNIRQFN
.|  .          ||....| . |...||.||.|  |.|.|.... ||... .      ..|.|.|||||||....|..|||..... |... .|.
sgwlpsy........rglgvvfghtavlrflkkngldliirghqvvpdgylpwfd......gklvtvfsapnylgrlgnlgavlaldeglvwgfklfa
subfamily_PPP4C_pd Subfamily PPP4C 96-369 1e-82 270.6 In-house 16-276 (288) alignment 
Range on Protein: 96-369
Range on HMM: 16-276/288.0
IEEAVALRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRH
|.|    .. ..   .| || |.  |..|.||||||||||.||..||.|||    |.||||||.||||..|.|. | | .||. ||  ..|.|||||.|.
ikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrq

LTEYFTFKQECIIKYS-ESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFGnektnefFsHNSVR
.|. . | .||. ||   ...  |.| || |.|||..... .|.||||||.| |||.|....| .| |  ||.|||||||| .  |       .   | |
itqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaeg.......w.avspr

GCSYFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQVtgfpslITIFSAPNYLDVYNNKAAVLKYENNVM
|  |.|  ... .| ..|..  |.|||.    ||... ...|      .|..|||||     |.||.|...... 
gagylfgsdvveqfneandielicrahqlvmegyklhfnekv......ltvwsapnycyrcgnvaaileldeeld
subfamily_PPP1C_pd Subfamily PPP1C 102-369 1.5e-82 270.0 In-house 16-270 (282) alignment 
Range on Protein: 102-369
Range on HMM: 16-270/282.0
LRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFT
 .....  ..| ..  ....|||....||||||. ||..||| .| |....||||||||||| .|.| .. | ..|| ||..| |||||||. ...... 
eallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasinriyG

FKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPledfgnEKTNEFFSHNSvRGCSYFFS
|. ||  .||  .. . ...|.|||||||.... ||.|||||||.  |..|....|  | | .| .||||||||      .|... .|.|. || |. |.
fydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdp......dkevlgwsend.rGvsftfg

YSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQvtgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
 ..  .|||||.|  |||||.  ..||... |.|      |.|.||||||.. ..|..|||. .....
kdvvekflqkndldlivrahqvvedGyeffakrq......lvtvfsapnycgefdnagavlsvdeell
subfamily_PPP2C_pd Subfamily PPP2C 100-378 5.4e-81 265.0 In-house 21-287 (290) alignment 
Range on Protein: 100-378
Range on HMM: 21-287/290.0
VALRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEY
   ... .   .|..|.|. .|..|.|||||.||||.||..|| .||    | ||||||||||||.|.|.| .| .||. |.  ...|||||| | .|. 
evkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqitqv

FTFKQECIIKYSE-SIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFGnektnefFsHNSVRGCSY
. | .||. ||.. ...    . ||.|||.||...| .|.||||||.| |||.|..|.|..| |  ||.|||||||| .  |       .   | ||. |
ygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrgg.......w.gisprgagy

FFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQVtgfpslITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQFNCSP
 |    . .| ..|.|  |.|||.    ||..  ...|      .||||||||     |.||.|. .... ... ||. .|
tfgkdisekfnktngltliarahqlvmegynwshdrnv......vtifsapnycyrcgnqaailelddklkysflqfdpap
subfamily_PPP5C_pd Subfamily PPP5C 84-381 4.3e-78 255.5 In-house 22-313 (322) alignment 
Range on Protein: 84-381
Range on HMM: 22-313/322.0
DALRQHFLLEGRIEEAVALRIITEGAALLREEKNMIDVEAP----ITVCGDIHGQFFDLVKLFEVGGPPAT-TRYLFLGDYVDRGYFSIECVLYLWSLKI
. | ..|  . .... .||.|..|  .||...  ..... .    .||||||||||.||. .||. | |..   ||| ||.|||| ||.|..| |...|.
kellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkl

TYPTTLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGL-SPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPLE
 ||  . | |||||  .. . . |..|.  ||.| ..|   | |. |||| ..|...| .|||| | .  ||||.....|...||  | ...|||||| |
lyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe

DFGNektneffsHNSVRGCSYFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQvtgfpsLITIFSAPNYLDVYNNKAAVLKY--ENNVMNIRQFN
  |          .| || .  |      .||..|||  |.|.|| .. ||.. .. .      |||.|||||| |  .||.|...   ... .....|.
anGr........spskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGk......litvfsapnycdqmgnkgafitlrgddlklkfktfe

CSPHPY
  .|| 
avehpd
subfamily_PPP6C_pd Subfamily PPP6C 108-374 6.6e-75 244.9 In-house 27-281 (290) alignment 
Range on Protein: 108-374
Range on HMM: 27-281/290.0
GAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQECI
 . || || |.  |..|.||||||||||.||..||  ||    |.|.||||.|||||.|.| . .| .||. ||  . |||||||.|..|. . | .||.
vldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygfydecl

IKYSES-IYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPlEDFgnektNEFfsHNSVRGCSYFFSYSACC
 || ..  .  |.. || |..||....| ||.||||||.. |||.|....| .| |  |..|||.|||| ||      ...  . | ||  |.|  . . 
nkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edv.....etw..avsprgagylfgskvtk

EFLQKNNLLSIVRAHEAQDAGYRMYRKNQvtgfpsLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQF
||.. |||  |.|||.  . |.. . ...      |.|..|||||     | |..|. |..   . . |
efvhinnlklicrahqlveeglkymfdek......lvtvwsapnycyrcgnvasilaledaeereaklf
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 94-369 4.5e-74 242.2 In-house 22-285 (298) alignment 
Range on Protein: 94-369
Range on HMM: 22-285/298.0
GRIEEAVALRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHEC
  |.|.   ..|..   .... | ...|.|||.||||||||. ||..||. .| | .. ||||||||||| ...| .. | . |. ||. . ||||||||
kvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnhec

RHLTEYFTFKQECIIKY-SESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPledfgnEKTNEFFSHNs
 .. . . |..||  .| | ..| .  ..|. |||.||. .. ||.|||||... .||....|.|  ...      ||||.||      |.. . ...| 
eainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadp......enavkgwaen.

VRGCSYFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQvtgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
 || |. |   .  ..|.| ..  .||||     || .. ...      |.||||||.|.. ..| |||.| .....
srGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekk......lvtifsaphycgqfdnsaavmkvdeklv
subfamily_PPG1_pd Subfamily PPG1 108-367 4.9e-74 242.3 In-house 26-285 (300) alignment 
Range on Protein: 108-367
Range on HMM: 26-285/300.0
GAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQECI
   || .| |.|....|.|| ||.||||.|....|..||.   | |||||||||||..|.| .  |  ||. ||. ..||||||| | .|. . |  ||.
lkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfytecl

IKY--SESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFGN---EKTNEF-FSHNSVRGCSYFFS
 ||     ...   | || | |||.....  |.||||||.. ..|.|| |.|||| |  | ..||||||| |.      .  .|  .  .| ||. | . 
rkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsqrgagysyg

YSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQVTgfpsliTIFSAPNYLDVYNNKAAVLKYENN
 .   .||..|..  |.|||.    ||...  |...      |..|||||     |||..|. ...
kdvvekflrnndmnriirahqlcnegyqilfdnkls......tvwsapnycyrcgnkasilelyek
PPP_4 125-324 6.5e-72 234.7 In-house 1-197 (197) alignment 
Range on Protein: 125-324
Range on HMM: 1-197/197.0
ITVCGDIHGQFFDL-VKLFEVGGPPA-TTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAF
.||.||||||..|| .||...|| |. ...|.|||||||||..|.|..|.|..||. ||... |||||||...|.....||.|.. |....|...... |
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

DCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPP-AYGPMCDL-LWSDPLedfgnEKTNEffSHNSVRGCSYFFSYSACCEFLQKNNLLSIVRA
|.||||||.....|..|||||.|. .||.|....|..| |   . ..|| |||||      |...   ..|||||....|.... ..||.|||| .|.|.
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpr.....eaqeg..lansvrGagllFgpdvtekfleknnlkliirs

HEAQ
||..
helk
PPP_2 125-323 1.7e-71 233.0 In-house 1-197 (198) alignment 
Range on Protein: 125-323
Range on HMM: 1-197/198.0
ITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQECI-IKYSESIYDACMEAFD
.|||||.|||. ||..||..|.|.....|||||||||||..|.|..|.|..||..||... |||||||.........||.|..  |.....|....| |.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

CLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLwsdPLEDFGNEKTNEFFSHNSVRGCSYFFSYSACCEFLQKNNLLSIVRAHEA
.||||||.....|..|||||.|| .||.||. .|..| |. |...|||   . |.. ..|..| . .||.||....|. .. .|.|.||.|  |.||||.
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldll...eeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_5_Dcr2 125-323 1e-67 221.0 In-house 1-198 (199) alignment 
Range on Protein: 125-323
Range on HMM: 1-198/199.0
ITVCGDIHGQFFDL-VKLFEVGGPPA-TTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQECIIK-YSESIYDACMEA
.|||||.|||..|| ..||. || |. ...|.|||||||||..|.|..|.|..||. || .. |||||||...|.|...|..|.. | ....||... . 
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPP-AYGPMCDL-LWSDPLedfgnEKTNEFFSHnSVRGCSYFFSYSACCEFLQKNNLLSIVR
||.||||||.....|..|||||||| ...... ..|..| |   | ..|| |||||      ..... . . |.||....|.... ..||.||||  |.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdpr.....daqegckln.seRGagllfgpdvtekfleknnlkliir

AHEA
.||.
shel
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 102-366 8.5e-67 218.1 In-house 16-270 (287) alignment 
Range on Protein: 102-366
Range on HMM: 16-270/287.0
LRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFT
| .. .   .|.  . ...||||||..||||||. ||...|.  | .. ..|||||||||||  |.| .|.|.||||.||  . |||||||.... . . 
levlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinklyG

FKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAY--GPMCDLLWSDPLEDfgnektNEFFSHNSVRGCSYF
||.|   |..|..|    . |. ||| | .... ||.|||.||.. .||..|.|.. . | |   | . ||||.|| .|      .. |  | .|. |  
fkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd......aktfelnkiraisvv

FSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQvtgfpsLITIFSAPNYLDVYNNKAAVLKYEN
|  .   ..|.| ..  |||||| .. || .. ...      |.|.|||| |     | .||.. ..
fGkkevddllkkldidlivrahevseeGyaflfdkr......lvtvfsapyysgedtnlgavvvvsk
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 96-367 1e-66 217.9 In-house 6-264 (280) alignment 
Range on Protein: 96-367
Range on HMM: 6-264/280.0
IEEAVALRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRH
|.||   |.| .   .|  .. |..|.||..||||.|||. ||..||.  . |  . ||||||||||| . .| .| | . |. || .. .||||||. .
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

LTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFGNektnefFSHNSvRG
. . . ||.|.  .||...|.   | .| |||.||.. . ||.|||||... .|||.. | |  ...      ||||.|| ..         ...|| ||
inrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtg......waens.rg

CSYFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQvtgfpsLITIFSAPNYLDVYNNKAAVLKYENN
.|. |      .. .| ..  |.| |.  . || .. ...      |.|.||||.||. ..|.||||. ...
vsvifganvvkdltekldidliarghqvvqdgyeffadkk......lvtvfsapkylgefdnsaavlivder
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 103-368 7.1e-66 215.3 In-house 15-267 (281) alignment 
Range on Protein: 103-368
Range on HMM: 15-267/281.0
RIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTF
 .| |  |.. |||.......||.| ||.|.|| || .|||. | .. ....|||||||||  |.|... |..|||.|.  . |||||||  ..   . |
nvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygf

KQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPledfgNEKTNEFFshNSVRGCSYFFSY
 .||  || | ..    . |. ||..|| ... ||.|||||||. .||...   .  ...  | . ||||.||     ..|..|..  .|.|| |. |  
yvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadp.....dnkveewk..assrGssftfGk

SACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQvtgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
.   .  .. ..  |.|||    .||..    .      |||.||.||| . |.| ||||| ....
nvvddvckrleveliirahqvvqdGyevlsgrk......litvfsvpnycafyknaaavlkvdetl
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 113-369 2e-65 214.1 In-house 25-274 (284) alignment 
Range on Protein: 113-369
Range on HMM: 25-274/284.0
REEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPP------ATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQEC
 .||  ...|||....||||||| ||. |... | |        ..||||||||||| |||| .. |...|. .|  . ||||||| | .   . | .||
wkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfylec

IIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFgnektNEFfsHNSVRGCSYFFSYSACC
  .|||..|.|   || ..||.|..... .|.|||.| ... |.... |.|  . |  | ..|| |.|| ..      . .  ..| ||.   |  .|  
kkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaev.....egy..kesprgagkvfgakavk

EFLQKNNLLSIVRAHEAQDAGYRMYRKNQvtgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
|||.| .|  .||||.    || ..  ..      |.|||||| |   ..| ||||. .....
eflkkfkldlvvrahqvvmdgyeffadrk......lvtifsapsycgqldniaavlnvdeelv
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 112-369 3.3e-61 200.1 In-house 40-285 (299) alignment 
Range on Protein: 112-369
Range on HMM: 40-285/299.0
LREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQECIIKYS
. ..  ...||||| ||||||||. ||...|.. | |  . .||||||||||   .| .  |   || ||  . .|||||||  .   . | .||  .| 
fasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecnkryk

-ESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPledfgNEKTNEFfsHNSVRGCSYFFSYSACCEFLQ
   .. .  .||. .||. |.. . ||.||||||.. ||| .. |.| ..||.     ||||.||     ..   ..  .. ||| || |      . ..
strlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadp.....dqsvkdw..lanvrgvsyvfgqdvvadvis

KNNLLSIVRAHEAQDAGYRMYRKNQvtgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
. ..  . |||.  . || .. ...      |.|||||| |   ..| ||..| ..|..
rldidlvarahqvvqdgyeffaskk......lvtifsaphycgqfdnsaaimkvdenlv
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 95-366 5.8e-60 196.1 In-house 22-283 (297) alignment 
Range on Protein: 95-366
Range on HMM: 22-283/297.0
RIEEAVALRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECR
 | |   |...     ... .|.|..|.||| ||||||||| ||..||  || | |. ||||||||||| |||| .. | . |. .|. | |||||||| 
viteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhece

HLTEYFTFKQECIIKY-SESIYDACMEAFDCLPLAALLNQQFLCIHGGLSP---EIFTLDDIKTLNRFREPpAYGPMCDLLWSDPLEDFgnektNEFFSH
 . . . | .||  .| |  .| |  . |. |||. |. .. ||.||||||   . |||| .. ..| .|    . ..||||.||.  .       |.  
fvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisgl.....sgfmen

NSVRGCSyfFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQvtgfpsLITIFSAPNYLDVYNNKAAVLKYEN
.   ||   |   |  .   . .|  ..|||.  . || ..   .      |.|||||| |   ..| ||..  ..
qrgagcg..fgrdavlklcsefkldlvcrahqvvqdgyeffagrk......lvtifsaphycgqfdncaafmscde
subfamily_PPZ_pd Subfamily PPZ 102-366 6.4e-58 189.6 In-house 31-282 (300) alignment 
Range on Protein: 102-366
Range on HMM: 31-282/300.0
LRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFT
|.|  .   |.  . .....  .. . ||.|||. ||..||   | | .. |||||||||||  |.| .| |.  || ||  . ||||||||  .|  . 
lqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrvyg

FKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEdfgneKTNEFfsHNSVRGCSYFFS
| .||  .    |. . ...|. |||||..  . .|.|||||| . ..|.|. . |  . | .| . ||||||| .      .||.   .  || || . 
fydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptd.....ssnew..ednergvsycyn

YSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNqvtgfpSLITIFSAPNYLDVYNNKAAVLKYEN
  |  .||.|  .  ..|||   . || ..         ||.|.||||||   ..|  ||.   .
kvainkflnkfgfdlvcrahmvvedgyeffndr......slvtvfsapnycgefdnwgavmsvse
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 103-368 3.9e-57 186.7 In-house 13-290 (302) alignment 
Range on Protein: 103-368
Range on HMM: 13-290/302.0
RIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGP-----------PATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNH
 .| .  .||..||..... .|.|. ||||||| |||...    .            .. ...|||||||||. ||||.  ...||. |||   ||||||
llieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnh

ECRHLTEYFTFKQECIIKYS----ESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGP-MCDLLWSDPLEDFGN--EKT
|.. .   ..|..|  ....      |..   |.|  .|||||. .. ||.|||.|| . .|.||| ..|  .  .  .   |||..|||.  .    ..
etkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaavse

NEFFSHNSVRGCSYFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQvtgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
.  . .| ||| |. |  .|  .. .. ||  |||||    .|.... ...      |.||||||.|..  .|| |||| . | 
kPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 102-364 5.2e-57 186.1 In-house 22-275 (290) alignment 
Range on Protein: 102-364
Range on HMM: 22-275/290.0
LRIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFT
| |. .   .|.    ...|||||.. ||||||. .|.. |.  | |   ..||||||||||  |.|  |.|. .|| |. .. |||||||.|..   . 
leilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrlyg

FKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPP--AYGPMCDLLWSDPLEDfgneKTNeFFSHNSVRGCSYF
||.| . | .  ..    . |. |.| | .... ||.|||.|..| . . .|.|.. | |     | . ||||.|| .|    |..  .. |  |. |  
fkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrd....kdd.tialnkqraisvv

FSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQvtgfpsLITIFSAPNYLDVYNNKAAVLKY
|  ..  ..|.|  |  |||||| .. |. .  ...      |.|.|||| |     |  |... 
fgkkglddllkklalslivrahevkeegfnflfdkk......lvtvfsapyysgndtnlgaiatv
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 103-368 6.1e-57 186.1 In-house 14-291 (302) alignment 
Range on Protein: 103-368
Range on HMM: 14-291/302.0
RIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGP-----------PATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNH
 .| .  .||..||..... .|.|. ||||||| |||...    .            .. ...|||||||||. ||||.  ...||. |||   ||||||
llieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnh

ECRHLTEYFTFKQECIIKYS----ESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGP-MCDLLWSDPLEDFGN--EKT
|.. .   ..|..|  ....      |..   |.|  .|||||. .. ||.|||.|| . .|.||| ..|  .  .  .   |||..|||.  .    ..
etkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaavse

NEFFSHNSVRGCSYFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQvtgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
.  . .| ||| |. |  .|  .. .. ||  |||||    .|.... ...      |.||||||.|..  .|| |||| . | 
kPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 150-368 1.8e-56 184.6 In-house 100-305 (317) alignment 
Range on Protein: 150-368
Range on HMM: 100-305/317.0
TTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTL
  .||||||||||| |||| |. | .||..||  . ||||||| | .   . | .|.  .||...|.|   || .|||.|..|.. ||.|||.| |.. |
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldl

DDIKTLNRFREPPAYGPMCDLLWSDPledfgnEKTNEFFsHNSVRGCSYFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQvtgfpsLITIFSAP
. ...|.|  . |  | ..|| |.||      ... . . ..| || .  |  .|  |||.| .|  .||||.    || ..   .      |.||||||
kqldklkrpldipdvGvladltwadp......daevkgy.kesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrk......lvtifsap

NYLDVYNNKAAVLKYENNV
.|    .| ||||. ....
sycGqldniaavlsvdkkl
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 103-373 8.8e-56 182.4 In-house 13-271 (280) alignment 
Range on Protein: 103-373
Range on HMM: 13-271/280.0
RIITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTF
 ||    |.. || |... |||| | |||| |. |. .||.. |     . .|||||||||   || .. |. ||| |   . |||||||   . . . |
aiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygf

KQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPledfgNEKTNEFFshNSVRGCSYFFSY
  ||  ||   ..     .|. .|...|.... ||.|||||||.  || |. . |  ||   | . |||||||      .| . .|   |.|| ||.|  
yvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdp.....tnkgegwf..hsirgisymfgk

SACCEFLQKNNLLSIVRAHEAQDAGYRMyrknqVTGFpSLITIFSAPNYLDVYNNKAAVLKYENNVM-NIRQ
    .  .  ..  |.|||.  . || |     ..|   |||.|| |||   . | |||.  . |.  ...|
gvveqacksleidliirahqvvqdgyem.....magr.rlitvfsvpnycaqftnaaavvclnanlqvsfqq
subfamily_PPPLV_pd Subfamily PPPLV 109-369 2.2e-55 181.0 In-house 10-281 (290) alignment 
Range on Protein: 109-369
Range on HMM: 10-281/290.0
AALLREEKNMIDVEAPITVCGDIHGQFFDLV----KLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQ
   | .|........|. | ||.||.. ||.    .|. .|   . . .|||||||||| ||.| . || .||. ||. . ||||||| . ..| ...| 
vdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykg

ECIIKYSE---SIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKT----LNRFREPPAYGPM-CDLLWSDPLED-----FGNEKTNEFFSHN
|.  |. .   ....| ...|| ||||| .... .|.|.|.   | |   | .    |.|....    |.  |.||||| ||      |.  .|| | .|
egsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGfvdn

SVRGCSYFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQvtgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
. || .. ||  |   ||..|||  ..||||....|.|. .| .      |.|.||. .|    |. | .|  .... 
drrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgr......lltvfsssrycGssneaalilvdkkklr
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 109-368 8.3e-55 179.2 In-house 16-264 (284) alignment 
Range on Protein: 109-368
Range on HMM: 16-264/284.0
AALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQECII
 ... ..  .|.|..|| .|||||||| ||..||.  | |  . |||||||||||   .| .| |.. |. .|  . .|||||||  . . . | .||  
fsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeecqr

KYS-ESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNR-FREPPAYGPMCDLLWSDPLEdFgnEKTnefFSHNSvRGCSYFFSYSACC
.|   |.| .    |  .||.||. |. ||.|||.|  .  . ......| | .|       |.||||| . |  .|    .  || || || |   |  
rynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptn.f..qkg...wnpns.rgvsyvfgsdalr

EFLQKNNLLSIVRAHEAQDAGYRMYRKNQvtgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
..|.. ..  .||||.  . || .. . .      |.|||||| |   ..| |||.  ..|.
klldrlqidlvvrahqvvqdgyeffanrr......lvtifsapfycgqfdnaaavmyvnknl
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 104-367 3.4e-51 167.2 In-house 28-281 (307) alignment 
Range on Protein: 104-367
Range on HMM: 28-281/307.0
IITEGAALLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFK
.| |  ...  || ..|.. |  | ||.|||| ||...| . | |  | |.| ||||||| .|.||.| |.. ||.||  . |||||||  .. . ..| 
viyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfy

QECI---IKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPMCDLLWSDPledfgneKTNEFFSHNSVRGCSYFF
.||.    |  | |.     .|. ||..||.  . ||.|||||| .  ||...   .    |  | . |.||.||           |  . | ||  . |
eecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadp.......dpsvfewkassrgsgftf

SYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNqvtgfpSLITIFSAPNYLDVYNNKAAVLKYENN
      .  ..  .  |.|||.    || .           |||||||| | ..|.|  .||| .. 
gtnviddvckrlgveliirahqmcfdgywvlsgr......klitifsapmycnfyknagcvlkvdet
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 118-364 4.1e-49 160.6 In-house 2-242 (263) alignment 
Range on Protein: 118-364
Range on HMM: 2-242/263.0
MIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQECIIKY-----SE
.....||| .||| |||. ||...|.  |  . |.||||||||||| .|.| .. |.|||.. |  . ||||||| . . . . |. |   ..      |
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

SIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREPPAYGPM-CDLLWSDPledfgnEKTNEFFSHNSVRGCSYFFSYSACCEFLQK
|.|.   . |  .||.|..... ||.|||.|| . .||||...    |     |. |||||.||      ||  . |  | .|  |  |      .. ..
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadp......ekdakgfepnkiraisnvfgkkevddlckr

NNLLSIVRAHEAQDAGYRMYRKNQvtgfpsLITIFSAPNYLDVYNNKAAVLKY
 ..  |||||.  . || ..   .      |||.|||  |     | |||.  
ldidlivrahqvveygyaffadrr......litvfsasryqielcnyaavvvv
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 151-367 6.7e-44 143.3 In-house 120-323 (339) alignment 
Range on Protein: 151-367
Range on HMM: 120-323/339.0
TRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLD
 |||||||||||| ||.| |. | .||..||  . ||||||| | .   . | .|   .|   .|..  . |. .|..|..|.  .|.|||.|  . ...
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

DIKTLNRFREPPAYGPMCDLLWSDPleDfGNEKTnefFsHNSVRGCSYFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQvtgfpsLITIFSAPN
..  ..|  | |  | . || |.||  |   ||    . . | ||.|. |   |   ||.| .|  ..| |.  . || ..   .      |.|||||||
qfsvfkrpleipdvgvltdltwadp..d.ptekg...y.kpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrr......lvtifsapn

YLDVYNNKAAVLKYENN
|    .| |||.  ...
ycgqndntaavfsidkk
Metallophos Calcineurin-like phosphoesterase 124-324 3.1e-40 131.6 Pfam-A 2-199 (200) alignment 
Range on Protein: 124-324
Range on HMM: 2-199/200.0
PITVCGDIHGQFFDL----VKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYL--WSLKITYPTTLSLLRGNHECRHLTEYFTFKQECI----------
.|.|.||.||.. ||     .|.......  . .|||||.||||  |.|.  .|  ..||...|. . |||||||........ |. |.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------IKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIktlnrfreppaygpmcdllwsdpledfgnek
                         ..  |..... | |..|||.|| ....|..||.||..  . |||                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

tneffshnsvrgCSYFFSYSACCEFLQKNNLLSIVRAHEAQ
            .|. |.. | ...|.|...  ..|.|. .
............gselfgpdalekllekygvdlvlrGHtHk
subfamily_PPP7C_pd Subfamily PPP7C 85-257 1.1e-31 102.9 In-house 22-201 (383) alignment 
Range on Protein: 85-257
Range on HMM: 22-201/383.0
ALRQHFLLEGRIEEAVALRIITEGAALLREEKNMIDVEA----PITVCGDIHGQFFDLVKLFEVGG-PPATTRYLFLGDYVDRGYFSIECVLYLWSLKIT
.| ..| .. ..     | |. | .  |.. .|.  |..     .|||||.||.. ||. ..   | | .   |.| ||.||||  |.| .| | .| . 
klieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllv

YPTTLSLLRGNHECRHLTEYFTFKQECIIKY---SESIYDACMEAFDCLPLAALLNQQFLCIHGGLSpEIFTLDDIKTLNR
||. . | |||||   |   . | .|   ||   .. |     . |  ||||.|.... | .|||.| ..  |. .. ..|
ypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkier
subfamily_PPP7C_pd Subfamily PPP7C 267-369 3.7e-14 45.2 In-house 237-326 (383) alignment 
Range on Protein: 267-369
Range on HMM: 237-326/383.0
MCDLLWSDPLEDFGnektnefFSHNSVRGCSYFFSYSACCEFLQKNNLLSIVRAHEAQDAGYRMYRKNQVtgfpslITIFSAPNYLDVYNNKAAVLKYEN
. |.||||| .. |          |..||   .|      ..||| ||  ..|.|| .  || .  ...|      .||||| || ..  |. | .|  .
vldilwsdpkakeG.......ckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkv......ltifsasnyyeeGsnrGayvklgk

NVM
...
dlt
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 111-149 1.7e-09 30.3 In-house 24-62 (317) alignment 
Range on Protein: 111-149
Range on HMM: 24-62/317.0
LLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPA
|. .|. ....|||.|..||||||| ||. |... | | 
lfwkeplkleleapvtivGdihGqfedllalldlnGwpl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 111-148 2.2e-06 20.0 In-house 26-63 (339) alignment 
Range on Protein: 111-148
Range on HMM: 26-63/339.0
LLREEKNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPP
|.  |  .. .|||| | ||||||| ||. .... | |
liwsepiflkleapicvmgdihgqfddllamldmngwp
subfamily_YNL217W_pd Subfamily YNL217W 124-247 5.7e-06 19.0 In-house 11-141 (235) alignment 
Range on Protein: 124-247
Range on HMM: 11-141/235.0
PITVCGDIHGQFFDLVKLFE--VGGPPATTRYLFLGDYVDRGYFSIECVLYLwslkitYPTTLSLLRGNHECRHLTEYFTFKQECIIKYS----------
 . | ||.|| . .|..|..  .||       ...|| ...|  |.| | |.        .    ..||||   | .|   |..  ..            
rllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsfle

ESIYDACMEAFDCLPLA-ALLNQQFLCIHGGLSPEIF
 .. .| ||    |. .  .  .. | .|.||.|  |
sklskadmeyarelgfsldipsdellvvhaGlvpgkf