Gene Pp2B-14D in Drosophila melanogaster

Synonym: CAN A1/PP2B, CG1455, CNA1, Can, Cana1, CnA, CnnA21EF, D14, DmCanA1-100B, Dmel\CG1455, PP2B, PP2B 21EF, PpD14, canA, pMY4, Dmel_CG1455, CanA1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP3C
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP099_AA protein Get Run
DmelP099_AA_148-351 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP3C_pd Subfamily PPP3C 81-543 5.6e-262 862.2 In-house 1-452 (452) alignment 
Range on Protein: 81-543
Range on HMM: 1-452/452.0
RVVDSVPFPPSHKLTLAEVFDQrTGKPNHELLKQHFILEGRIEEAPALKIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYL
|||..||.|.|.||| .||||. ||||..|.||.||. |||.||. |||||...|.||..|||....|||.||.||||||||||.|||||||.|||||||
rvvkkvplpkskklteeevfde.tgkpklevlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkyl

FLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRR
|||||||||||||||||||..|||.||.|||||||||||||||||||||.||||||||.||||||..||.||||||.|||||||||||||||..|.||..
flGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikk

LDRFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDV
|||||||||.||.|||||||||||.|.||.......||||||||||||.|.|.|||.|.|||||||||||||||||||||..||||||||.|||||||||
ldrfkeppasGplcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldv

YNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELMTEESEEPLSDDEAALRKEVIRNKIRAIGKMARVFSV
|||||||||||||||||||||.|||||||||||||||||||||||||||||||.|||||||||..||.||  ...|.. ||||||||||||||.||||||
ynnkaavlkyennvmnirqfnssphpywlpnfmdvftwslpfvgekvtemlvnilnicsddelekeeeeeskeesesekrkevirnkiraigklarvfsv

LREESESVLQLKGLTpTGALPLGALSGGKQSLknamqgfspNHKITSFAEAKGLDAVNERMPP
|||||||||.||||| ||||| ||||.||..|         ..|..||.|||.||..||..||
lreesesvlllkglt.tgalprgalsegkegl.........eeklssfeeakkldlineklpp
0045823 Metallo-dependent phosphatases 80-542 2.1e-152 500.9 In-house 2-471 (473) alignment 
Range on Protein: 80-542
Range on HMM: 2-471/473.0
ERVVDSVPFPPSHKLTLAEVFDQRtGKPNHELLKQHFILEGRIEEAPALKIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKY
.||...|..|....|||...|.   |.....||..|.. ||...|  .||.... . .|..|...........|.||||||..||..|.|  | | ....
drvlklvlipvlrlltlpllfill.glldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrl

LFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIR
.||||.||||..|.|....|..||| ||.  ||||||||.|.|. .. |..|.  ||.|..|..... ...|||||. ....|.|||||||... |..||
vflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqir

RLDRFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLD
...|. |.| .|...||||||| ||.|...    . .||.||..|.... | ..||..|.|  |.|.|.... ||..... ...|....||.||||||..
eierpleipddgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcg

VYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELMTEESEEPLSddEAALRKEVIRNKIRAIGKMARVFS
...|.||||..........||..||||..||.|.|||..||||..||.||.|...|||.|||||...|.. .|       ..|..||||.|.||..||||
rggnlaAvlvidedlisfiqfdpsphplilplfldvfllslpfllekltellllllnivsddellededilgll..lleallellrnkilalgkllrvfs

VLREESESVLQLKGLTPTGALPLGALSGGKQSLKNAMQ----------GFSPNHKITSFAEAKGLDAVNERMP
||||||||||.||||||.| ||||.|. ||. | ....           ..|.....|. |.| |. .|||..
vlreesesvlllkgltpsgllplgllllgkelllesleealkldlineklppsllllsleeekslelinerle
PPP_1 125-388 5.1e-105 343.5 In-house 4-262 (264) alignment 
Range on Protein: 125-388
Range on HMM: 4-262/264.0
APALKIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTE
. . ....  . ||..|..........||||||||||.||.|||.|||....|.|||||||||||..|.|..|.|..||. ||..|||||||||.|..|.
eelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtk

YFTFKQECK-IKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCS
...||.|..  |||...|....|.||.||||||.....|.||||||||.. |..||...|..| |. |..||||..|  ... ..|...  ..||.||..
vygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGag

YFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQTtgfpslITIFSAPNYLDVYNNKAAVL
|.... . ..|||.||| .||||||....||....|...      .|||||.|| .. .|..|..
ylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkv......vtifsasnyyeegsnrgayv
PP2Ac_SM00156 126-395 7.3e-105 342.9 In-house 5-261 (271) alignment 
Range on Protein: 126-395
Range on HMM: 5-261/271.0
PALKIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEY
 .|..... ...|.|||......|||||.||||||..||..|.| .| |...||.|||||||||..|||..|.|..||| ||....|||||||.......
evlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvnki

FTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPledfgnEKNSDFYTHNSvRGCSYF
..|..|.|.||....|. ...||..||||||.....||.|||||||...|.|||.|.|.||.|  |...|||||||      |.. . ..... ||.|..
ygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdp......eqkekgfqpsk.rglsvv

YSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSqttgfpSLITIFSAPNYLDVYNNKAAVLKYENNVM
.. .| ..||..|||  ||||||..| ||... ..      .|.||||||||.| ..|||||||.|.|..
FgedavkeflkknnlkliiRahevvdeGyeffadk......klvtifsapnycdefsnkaavlkveknlk
PPP_3 124-395 1.1e-95 312.7 In-house 4-263 (271) alignment 
Range on Protein: 124-395
Range on HMM: 4-263/271.0
EAPALKIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLT
|  . ....  . .| .|.....|.||||||||||||..||..||..||....|||||||||||||..|.|..|.|..|||.||....|||||||.|...
enelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqin

EYFTFKQECK-IKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLedfgnekNSDFYTHNSVRGC
....||.|..  |....||..... |..||||||.....|.|||||||.|..|..|..|.|..| |  |...|||.|..        ...  ..||.||.
kvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdp.......ekeeglenskrGa

SYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKsqttgfPSLITIFSAPNYLDVYNNKAAVLKYENNVM
.....  . ..||..|.|  ||||||....||.....       ...|.||||||.. ..|..|.|| |.. .
gllFgpdvteefleknkLkliiRaHelkeeGyeilhd......gkvvtvfSapnycerasnagailkleealt
0049330 Metallo-dependent phosphatases 106-409 3.6e-95 311.6 In-house 14-305 (309) alignment 
Range on Protein: 106-409
Range on HMM: 14-305/309.0
KPNHELLKQHFILEGRIEEAPALKIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKIT
... .||..... .....|  .|....    .|..|...........|.||||||..||..|.|  | | .....||||.||||..|.|..|.|..||. 
lslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkll

YPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDF
||.  ||||||||.|.|. .. |..|.. ||.........| ...|||||. ....|||||||||... |..||.|.|. |.|..|..|||||||||...
ypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpir

GNeknsdfyTHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENN-VMNIRQFNCSP
 .        ....||..... . | ..||. |.|  |||.|.|.. ||... . .      |||.||||||.....|..|||..... |.....|...|
eg.......fapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgk......litvfsapnycgrlgnlgavleidedlvisfllfepvp

HPYWL
....|
lllll
0053225 Metallo-dependent phosphatases 106-401 3.2e-89 292.2 In-house 6-289 (293) alignment 
Range on Protein: 106-401
Range on HMM: 6-289/293.0
KPNHELLKQHFILEGRIEEAPALKIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKIT
.....||.....|  .. |  .|....    .|..|...........|.|||||...||..|.|  | | .....||||.||||..|.|....|..||. 
lllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkll

YPQTLFLLRGNHECRHLTEYFTFKQECKIKY-SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLED
||.  .|||||||...|. .. |..|.. || .....|...| ...|||||| ....|.|||||||... |..||...|. ..| .|...||||||| . 
ypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlw

FGNEKNSdfythnsvRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKsqttgfPSLITIFSAPNYLDVYNNKAAVLKYENN-VMNIRQFN
.|  ..         ||..... . |...||..|.|  |||.|.... ||... .      ..|.|.|||||||....|..|||..... |... .|.
sgwlpsy........rglgvvfghtavlrflkkngldliirghqvvpdgylpwfd......gklvtvfsapnylgrlgnlgavlaldeglvwgfklfa
subfamily_PPP1C_pd Subfamily PPP1C 124-395 2.3e-87 285.8 In-house 12-270 (282) alignment 
Range on Protein: 124-395
Range on HMM: 12-270/282.0
EAPALKIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLT
||   ....   ..| .. .....||||...||||||..||..||| .|.|....||||||||||| .|.| .. | ..|| ||..|||||||||. ...
eaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasin

EYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPledfgNEKNSDfYTHNSvRGCS
... |. ||| .|| ... . .|.|.|||||||.... ||||||||||...||.||.. |  | |  | .||||||||     .... . ...|. || |
riyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdp.....dkevlg.wsend.rGvs

YFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
. ..  .  .|||.|.|  |.|||.  ..||... | |      |.|.||||||.. ..|..|||. .....
ftfgkdvvekflqkndldlivrahqvvedGyeffakrq......lvtvfsapnycgefdnagavlsvdeell
subfamily_PPP4C_pd Subfamily PPP4C 122-395 3.9e-82 268.7 In-house 16-276 (288) alignment 
Range on Protein: 122-395
Range on HMM: 16-276/288.0
IEEAPALKIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRH
|.|    .. ..   .| .|  .  ...|||||||||||||||..||.|||.  .|.||||||.||||..|.|. | | .||. ||. . |.|||||.|.
ikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrq

LTEYFTFKQECKIKY-SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGneknsdfYtHNSVR
.|. . | .||  || | .|.  |.. || |.|||..... .||||||||.|..|..|| .|| .| |  ||.|||||||| .  |       .   | |
itqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaeg.......w.avspr

GCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
|  |..   .. .| ..|..  |.|||.    ||... . .      ..|..|||||     |.||.|...... 
gagylfgsdvveqfneandielicrahqlvmegyklhfnek......vltvwsapnycyrcgnvaaileldeeld
subfamily_PPP5C_pd Subfamily PPP5C 111-408 2.4e-80 263.0 In-house 24-314 (322) alignment 
Range on Protein: 111-408
Range on HMM: 24-314/322.0
LLkQHFILEGRIEEAPALKIIQDGAALLRQEKTMIDIEAP----VTVCGDIHGQFYDLMKLFEVGGSPAST-KYLFLGDYVDRGYFSIECVLYLWSLKIT
|| ..|  . ....  ||||...  .||... ....|. .    .|||||||||||||. .||. |.|...  ||| ||.|||| ||.|..| |...|. 
ll.elfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkll

YPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLS-PEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLED
||. .|| |||||  .. . . |..|.| ||.|.|.|   . |. |||| ..|...| |||||   .   |.|.|..||...||  | ...|||||| | 
yPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqea

FGNeknsdfytHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKY--ENNVMNIRQFNC
 |          .| || .  .       ||..|||  |||.|| .. ||.. .. .      |||.|||||| |  .||.|...   ... .....|. 
nGr........spskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGk......litvfsapnycdqmgnkgafitlrgddlklkfktfea

SPHPYW
 .||  
vehpdv
subfamily_PPP2C_pd Subfamily PPP2C 123-404 4.4e-80 262.0 In-house 18-287 (290) alignment 
Range on Protein: 123-404
Range on HMM: 18-287/290.0
EEAPALKIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHL
||.   ....    .|..|. . ....|||||||.||||.||..|| .||.   |.||||||||||||.|.|.| .| .||. |.. . .|||||| | .
eesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqi

TEYFTFKQECKIKYSE-RVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGneknsdfYtHNSVRG
|. . | .||  ||..  |.    | ||.|||.||...| .|.||||||.|. |..|| |||..| |  ||.|||||||| .  |       .   | ||
tqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrgg.......w.gisprg

CSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQFNCSP
. | .    . .| ..|.|  |.|||.    ||..  . .      ..||||||||     |.||.|. .... ... ||. .|
agytfgkdisekfnktngltliarahqlvmegynwshdrn......vvtifsapnycyrcgnqaailelddklkysflqfdpap
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 121-395 1.2e-75 247.3 In-house 23-285 (298) alignment 
Range on Protein: 121-395
Range on HMM: 23-285/298.0
RIEEAPALKIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECR
 |.|.   |.|.    .... |......||..||||||||. ||..||. .| | .. ||||||||||| ...| .. | . |. ||. .||||||||| 
vikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnhece

HLTEYFTFKQECKIKY-SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPledfgNEKNSDFyThNSV
.. . . |..||| .| | |.| .  |.|. |||.||. .. ||.|||||.....|...|.| | ....      ||||.||     ... ... . .. 
ainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadp.....enavkgw.a.ens

RGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
|| |. .   .  |.|.. ..  ..|||     || .. . .      |.||||||.|.. ..| |||.| .....
rGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekk......lvtifsaphycgqfdnsaavmkvdeklv
PPP_4 151-350 1.2e-73 240.4 In-house 1-197 (197) alignment 
Range on Protein: 151-350
Range on HMM: 1-197/197.0
VTVCGDIHGQFYDL-MKLFEVGGSPA-STKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAF
|||.||||||..|| .||...|| |. ...|.|||||||||..|.|..|.|..||. ||....|||||||...|.....||.|.. |..........| |
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

DCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPP-AFGPMCDL-LWSDPLedfgnEKN-SdfyTHNSVRGCSYFYSYAACCDFLQNNNLLSIIR
|.||||||.....|.||||||.|...|..|.|..|..| |   . ..|| |||||      |..     ..|||||....... . ..||..||| .|||
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpr.....eaqeg...lansvrGagllFgpdvtekfleknnlkliir

AHEAQ
.||..
shelk
subfamily_PPP6C_pd Subfamily PPP6C 129-400 1.3e-73 240.7 In-house 22-281 (290) alignment 
Range on Protein: 129-400
Range on HMM: 22-281/290.0
KIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTF
|. .  . || .| ..  ...|||||||||||||||..||  ||.   |.|.||||.|||||.|.| . .| .||. ||. . |||||||.|..|. . |
klcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygf

KQECKIKYSE-RVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPlEDFGNeknsdfYtHNSVRGCSYFYS
 .||. || .  ..  |.. || |..||....| |||||||||... |..|| ..| .| |  |..|||.|||| ||  .      . . | ||  |.. 
ydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvet......w.avsprgagylfg

YAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQF
   . .|...|||  |.|||.  . |.. . . .      |.|..|||||     | |..|. |..   . . |
skvtkefvhinnlklicrahqlveeglkymfdek......lvtvwsapnycyrcgnvasilaledaeereaklf
PPP_2 151-349 1.1e-72 237.0 In-house 1-197 (198) alignment 
Range on Protein: 151-349
Range on HMM: 1-197/198.0
VTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECK-IKYSERVYDACMDAFD
||||||.|||..||..||..|......||||||||||||..|.|..|.|..||..||....|||||||.........||.|..  |....||..... |.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

CLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLwsdPLEDFGNEKNSDFYTHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEA
.||||||.....|.||||||.||..|..|.. .|..| |. |...|||   . |.. ..|...  ..||.||......  . ...|..|.|  ||||||.
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldll...eeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_PPG1_pd Subfamily PPG1 135-393 2.5e-72 236.7 In-house 27-285 (300) alignment 
Range on Protein: 135-393
Range on HMM: 27-285/300.0
AALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKI
  || .|  .|.|..|||| ||.||||||....|..||    |.|||||||||||..|.| .  |  ||. ||  . ||||||| | .|. . |  ||  
kellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyteclr

KY--SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDF----GNEKNSDFYTHNSVRGCSYFYSY
||    ||..   . || | |||.....  ||||||||..  ...|. ||||.| |  | ..||||||| |.      .  ..  .  .| ||. | |  
kyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsqrgagysygk

AACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTgfpsliTIFSAPNYLDVYNNKAAVLKYENN
     ||.||..  |||||.    ||...  .. .      |..|||||     |||..|. ...
dvvekflrnndmnriirahqlcnegyqilfdnkls......tvwsapnycyrcgnkasilelyek
PPP_5_Dcr2 151-349 3.2e-69 225.9 In-house 1-198 (199) alignment 
Range on Protein: 151-349
Range on HMM: 1-198/199.0
VTVCGDIHGQFYDL-MKLFEVGGSPA-STKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIK-YSERVYDACMDA
||||||.|||..|| ..||. || |. ...|.|||||||||..|.|..|.|..||. ||....|||||||...|.|...|..|.. | .....|... | 
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPP-AFGPMCDL-LWSDPLedfgneKNSDFYTHNSVRGCSYFYSYAACCDFLQNNNLLSIIR
||.||||||.....|.|||||||||...|......|..| |   | ..|| |||||       .. . .  ||.||....... . ..||..|||  |||
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdpr......daqegcklnseRGagllfgpdvtekfleknnlkliir

AHEA
.||.
shel
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 138-395 7.1e-68 222.1 In-house 24-274 (284) alignment 
Range on Protein: 138-395
Range on HMM: 24-274/284.0
LRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSP------ASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQE
. .||  ..|||||...||||||| ||. |... | |       ..|||||||||||| |||| .. |...|. .|. .|||||||| | .   . | .|
fwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyle

CKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFgneknsDFYtHNSVRGCSYFYSYAAC
|| .|||..|.|   || ..||.|..... .|.|||.| .. .|... .|.|  . |  | ..|| |.|| ..       . | ..| ||.   .  .| 
ckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaev......egy.kesprgagkvfgakav

CDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
 .||.. .|  ..|||.    || ..   .      |.|||||| |   ..| ||||. .....
keflkkfkldlvvrahqvvmdgyeffadrk......lvtifsapsycgqldniaavlnvdeelv
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 122-393 1.3e-67 220.9 In-house 6-264 (280) alignment 
Range on Protein: 122-393
Range on HMM: 6-264/280.0
IEEAPALKIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRH
|.||   ..|.    .|  ..||....|||.||||.|||. ||..||.  . |  ..||||||||||| . .| .| | . |. ||.....||||||. .
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

LTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPledfgnEKNSDFYTHNSvRG
. . . ||.|.| .||. .|.   . .| |||.||.. . ||.|||||...  |.|...| |  ...      ||||.||      |..   ...|| ||
inrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadp......enkvtgwaens.rg

CSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENN
.|. .      |. .  ..  |.| |.  . || .. . .      |.|.||||.||. ..|.||||. ...
vsvifganvvkdltekldidliarghqvvqdgyeffadkk......lvtvfsapkylgefdnsaavlivder
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 127-392 3.9e-67 219.2 In-house 15-270 (287) alignment 
Range on Protein: 127-392
Range on HMM: 15-270/287.0
ALKIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYF
 |....    .|.  ......|||.|..||||||. ||...|.  | .. ..|||||||||||  |.| .|.|.||||.||. . |||||||.... . .
ilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinkly

TFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAF--GPMCDLLWSDPledfgnEKNSDFYTHNSVRGCSY
 ||.| | |..||.|    | |. ||| | .... ||.|||.||... |.... | . . | |   | . ||||.||      ||... .  | .|. | 
GfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadp......ekdaktfelnkiraisv

FYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYEN
 .      |.|.. ..  |.|||| .. || .. . .      |.|.|||| |     | .||.. ..
vfGkkevddllkkldidlivrahevseeGyaflfdkr......lvtvfsapyysgedtnlgavvvvsk
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 129-394 1.4e-65 214.3 In-house 15-267 (281) alignment 
Range on Protein: 129-394
Range on HMM: 15-267/281.0
KIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTF
..|.   |.. .||....|..|..| ||.|.|| || .|||. | .. ....|||||||||  |.|... |..|||.|.. ..|||||||  ..   . |
nvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygf

KQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPledfgneKNSDFYTHNSVRGCSYFYSY
 .||. || | ..      |. ||..||.... ||.|||||||.  |...|   .  ...  | . ||||.||       .|. .  ..|.|| |. .  
yvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadp.......dnkveewkassrGssftfGk

AACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
.   |  .. ..  |||||    .||..    .      |||.||.||| . |.| ||||| ....
nvvddvckrleveliirahqvvqdGyevlsgrk......litvfsvpnycafyknaaavlkvdetl
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 137-395 5.6e-63 205.9 In-house 39-285 (299) alignment 
Range on Protein: 137-395
Range on HMM: 39-285/299.0
LLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIKY
 . .. .....|||. ||||||||. ||...|.. | |  ...||||||||||   .| .  |   || ||. .|.|||||||  .   . | .||. .|
vfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecnkry

-SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPledfgNEKNSDFytHNSVRGCSYFYSYAACCDFL
 | |.. .  |||. .||. |.. . ||.||||||....|. .| | | ..||.     ||||.||     ..   |.  .. ||| || .      | .
kstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadp.....dqsvkdw..lanvrgvsyvfgqdvvadvi

QNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
.. ..  . |||.  . || .. . .      |.|||||| |   ..| ||..| ..|..
srldidlvarahqvvqdgyeffaskk......lvtifsaphycgqfdnsaaimkvdenlv
subfamily_PPZ_pd Subfamily PPZ 128-392 6.4e-63 206.0 In-house 31-282 (300) alignment 
Range on Protein: 128-392
Range on HMM: 31-282/300.0
LKIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFT
|.| .    |.  . .....  .| . ||.|||. ||..||   | | |..|||||||||||  |.| .| |.  || ||. .|||||||||  .|  . 
lqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrvyg

FKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLeDFGNEKNsdfythNSVRGCSYFYS
| .||| .   ... . .|.|. |||||..  . .|||||||| .  ...||.. |  . | || . |||||||  |  || .      .  || || | 
fydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdpt.dssnewe......dnergvsycyn

YAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSqttgfpSLITIFSAPNYLDVYNNKAAVLKYEN
  |   ||..  .  . |||   . || ..         ||.|.||||||   ..|  ||.   .
kvainkflnkfgfdlvcrahmvvedgyeffndr......slvtvfsapnycgefdnwgavmsvse
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 121-392 7.1e-62 202.4 In-house 22-283 (297) alignment 
Range on Protein: 121-392
Range on HMM: 22-283/297.0
RIEEAPALKIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECR
 | |   ||...    .....|.|....||. ||||||||| ||..||  || | ...||||||||||| |||| .. | . |. .|  |||||||||| 
viteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhece

HLTEYFTFKQECKIKY-SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSP---EIHELEDIRRLDRFKEPpAFGPMCDLLWSDPLEDFgneknSDFYTH
 . . . | .||. .| | |.| |  | |. |||. |. .. ||.||||||   .   |. .|...| .|    . ..||||.||.  .     | |   
fvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisgl.....sgfmen

NSVRGCSYfySYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYEN
.   || .     |  .   . .|  . |||.  . || ..   .      |.|||||| |   ..| ||..  ..
qrgagcgf..grdavlklcsefkldlvcrahqvvqdgyeffagrk......lvtifsaphycgqfdncaafmscde
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 128-394 5.5e-60 196.1 In-house 12-290 (302) alignment 
Range on Protein: 128-394
Range on HMM: 12-290/302.0
LKIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGG-----------SPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGN
|..|.   .||..|||...| .|||. ||||||| ||....               | .| |..|||||||||. ||||.  ...||. ||.   |||||
lllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgn

HECRHLTEYFTFKQECKIKYSE----RVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAF-GPMCDLLWSDPLEDFG--NEK
||.. .   ..|..| ......    ....   ..|  .|||||. .. ||||||.|| .. ||||....|  .  .      |||..|||.  .    .
hetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaavs

NSDFYTHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
.   |..| ||| |. .  ||  |. .. ||  |.|||    .|.... . .      |.||||||.|..  .|| |||| . | 
ekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 128-394 9.1e-60 195.4 In-house 13-291 (302) alignment 
Range on Protein: 128-394
Range on HMM: 13-291/302.0
LKIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGG-----------SPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGN
|..|.   .||..|||...| .|||. ||||||| ||....               | .| |..|||||||||. ||||.  ...||. ||.   |||||
lllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgn

HECRHLTEYFTFKQECKIKYSE----RVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAF-GPMCDLLWSDPLEDFG--NEK
||.. .   ..|..| ......    ....   ..|  .|||||. .. ||||||.|| .. ||||....|  .  .      |||..|||.  .    .
hetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaavs

NSDFYTHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
.   |..| ||| |. .  ||  |. .. ||  |.|||    .|.... . .      |.||||||.|..  .|| |||| . | 
ekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 177-394 3.7e-57 186.9 In-house 101-305 (317) alignment 
Range on Protein: 177-394
Range on HMM: 101-305/317.0
TKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELE
 |||||||||||| |||| |. | .||..||. .|||||||| | .   . | .|.| .||...|.|   || .|||.|..|.. ||.|||.| |. .|.
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

DIRRLDRFKEPPAFGPMCDLLWSDPledfgnEKNSDFYtHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPN
 . .|.|  . |  | ..|| |.||      ... . | ..| || .  .  .|  .||.. .|  ..|||.    || ..   .      |.||||||.
qldklkrpldipdvGvladltwadp......daevkgy.kesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrk......lvtifsaps

YLDVYNNKAAVLKYENNV
|    .| ||||. ....
ycGqldniaavlsvdkkl
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 126-390 1.3e-56 184.8 In-house 20-275 (290) alignment 
Range on Protein: 126-390
Range on HMM: 20-275/290.0
PALKIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEY
  |.|..    .|.   .....|||... ||||||. .|.. |.  | |   |.||||||||||  |.|  |.|. .|| |.... |||||||.|..   
dileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrl

FTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPP--AFGPMCDLLWSDPLEDfgnekNSDFYTHNSVRGCS
. ||.|   | . |..    | |. |.| | .... ||.|||.|..|.  | .. | . . |     | . ||||.|| .|      .| .. |  |. |
ygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrd.....kddtialnkqrais

YFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKY
  .   .  |.|..  |  |.|||| .. |. .  . .      |.|.|||| |     |  |... 
vvfgkkglddllkklalslivrahevkeegfnflfdkk......lvtvfsapyysgndtnlgaiatv
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 136-394 8.1e-56 182.5 In-house 17-264 (284) alignment 
Range on Protein: 136-394
Range on HMM: 17-264/284.0
ALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIK
... ..  .|....|. .|||||||| ||..||.  | |  ..|||||||||||   .| .| |.. |. .|. .|.|||||||  . . . | .||. .
sifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeecqrr

YSE-RVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDR-FKEPPAFGPMCDLLWSDPLeDFGNEKNsdfytHNSvRGCSYFYSYAACCD
| .  || .    |  .||.||. |. ||.|||.|  .... ..| . | | .|       |.|||||  .| .  |      || || || .   |   
ynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdpt.nfqkgwn.....pns.rgvsyvfgsdalrk

FLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
.|.  ..  ..|||.  . || .. . .      |.|||||| |   ..| |||.  ..|.
lldrlqidlvvrahqvvqdgyeffanrr......lvtifsapfycgqfdnaaavmyvnknl
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 129-399 2.3e-55 181.1 In-house 13-271 (280) alignment 
Range on Protein: 129-399
Range on HMM: 13-271/280.0
KIIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTF
 ||.   |.. .|  ... |||. | |||| |. |. .||.. |     | .|||||||||   || .. |. ||| | . ..|||||||   . . . |
aiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygf

KQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLedfgNeKNSDFYtHnSVRGCSYFYSY
  ||. ||   ..     .|. .|...|.... ||.|||||||. .|. || . |  ||   | . |||||||     | |   .. | |.|| ||..  
yvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdpt....n.kgegwf.h.sirgisymfgk

AACCDFLQNNNLLSIIRAHEAQDAGYRMYrksqtTGfPSLITIFSAPNYLDVYNNKAAVLKYENNVM-NIRQ
.   .  .. ..  |||||.  . || |      .|   |||.|| |||   . | |||.  . |.  ...|
gvveqacksleidliirahqvvqdgyemm.....ag.rrlitvfsvpnycaqftnaaavvclnanlqvsfqq
subfamily_PPPLV_pd Subfamily PPPLV 135-395 6.3e-55 179.5 In-house 10-281 (290) alignment 
Range on Protein: 135-395
Range on HMM: 10-281/290.0
AALLRQEKTMIDIEAPVTVCGDIHGQFYDLM----KLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQ
   | .|. ......|. | ||.||.. ||.    .|. .|   . ...|||||||||| ||.| . || .||. ||  ..||||||| . ..| ...| 
vdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykg

ECKIKYSE---RVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRR----LDRFKEPPAFGPMC-DLLWSDPLEDF-----GNEKNSDFYTHN
|.. |. .    |..| ...|| ||||| .... .|||.|.   |.    |      |.|.|..    |.  |.||||| ||      |.   .. . .|
egsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGfvdn

SVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
. || .. .| .|   ||..|||  ..||||....|.|. .|..      |.|.||. .|    |. | .|  .... 
drrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgr......lltvfsssrycGssneaalilvdkkklr
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 130-393 9.6e-51 165.8 In-house 28-281 (307) alignment 
Range on Protein: 130-393
Range on HMM: 28-281/307.0
IIQDGAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFK
.| .  ...  ||...||. |. | ||.|||| ||...| . | |  | |.| ||||||| .|.||.| |.. ||.||. . |||||||  .. . ..| 
viyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfy

QECKI---KYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPledfgneKNSDFYTHNSVRGCSYFY
.||     |  | ..     .|. ||..||.  . ||.|||||| .  |...|   .    |  | . |.||.||         | |  . | ||  . .
eecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadp.......dpsvfewkassrgsgftf

SYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSqttgfpSLITIFSAPNYLDVYNNKAAVLKYENN
      |  .   .  |||||.    || .           |||||||| | ..|.|  .||| .. 
gtnviddvckrlgveliirahqmcfdgywvlsgr......klitifsapmycnfyknagcvlkvdet
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 144-390 8.1e-50 162.9 In-house 2-242 (263) alignment 
Range on Protein: 144-390
Range on HMM: 2-242/263.0
MIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIKYS-ERVYD
.....||. .||| |||. ||...|.  |. . |.||||||||||| .|.| .. |.|||.. |. ..||||||| . . . . |. | | ..  | ||.
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

----ACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEPPAFGPM-CDLLWSDPledfgnEKNSDFYTHNSVRGCSYFYSYAACCDFLQN
       . |  .||.|..... ||.|||.|| .. |.||| .    |     |. |||||.||      ||..  .  | .|  |  .      |. . 
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadp......ekdakgfepnkiraisnvfgkkevddlckr

NNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKY
 ..  |.|||.  . || ..   .      |||.|||  |     | |||.  
ldidlivrahqvveygyaffadrr......litvfsasryqielcnyaavvvv
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 178-393 1.7e-43 142.1 In-house 121-323 (339) alignment 
Range on Protein: 178-393
Range on HMM: 121-323/339.0
KYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELED
.||||||||||| ||.| |. | .||..||. ..||||||| | .   . | .| . .|  ..|..  . |. .|..|..|.  .|.|||.|  .  ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRRLDRFKEPPAFGPMCDLLWSDPleDfGNEKNsdfYtHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNY
.  . |  | |  | . || |.||  |   ||    | . | ||.|. .   |   ||.. .|  .|| |.  . || ..   .      |.||||||||
fsvfkrpleipdvgvltdltwadp..d.ptekg...y.kpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrr......lvtifsapny

LDVYNNKAAVLKYENN
    .| |||.  ...
cgqndntaavfsidkk
Metallophos Calcineurin-like phosphoesterase 150-350 5.1e-42 137.4 Pfam-A 2-199 (200) alignment 
Range on Protein: 150-350
Range on HMM: 2-199/200.0
PVTVCGDIHGQFYDL----MKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLYL--WSLKITYPQTLFLLRGNHECRHLTEYFTFKQECK----------
...|.||.||...||    ..|.......  . .|||||.||||  |.|.  .|  ..||...|  .||||||||........ |. |.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------IKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIrrldrfkeppafgpmcdllwsdpledfgnek
                         ..  ...... . |..|||.|| ....|..||.||..    .||                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

nsdfythnsvrgCSYFYSYAACCDFLQNNNLLSIIRAHEAQ
            .|. ... | ...|.....  ..|.|. .
............gselfgpdalekllekygvdlvlrGHtHk
subfamily_PPP7C_pd Subfamily PPP7C 128-285 1.2e-33 109.4 In-house 39-203 (383) alignment 
Range on Protein: 128-285
Range on HMM: 39-203/383.0
LKIIQDGAALLRQEKTMIDIE----APVTVCGDIHGQFYDLMKLFEVGGSPAS-TKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHL
|.|... .  |.| . .  ..      ||||||.||.. ||. ..   | |..   |.| ||.||||  |.| .| | .| . ||. ..| |||||   |
llilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhil

TEYFTFKQECKIKY---SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSpEIHELEDIRRLDRFK
   . | .| . ||   ....     | |  ||||.|.... | ||||.| .. .|| . ...| |
nlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkiersk
subfamily_PPP7C_pd Subfamily PPP7C 293-395 2.3e-12 39.4 In-house 237-326 (383) alignment 
Range on Protein: 293-395
Range on HMM: 237-326/383.0
MCDLLWSDPLEDFGNeknsdfyTHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYEN
. |.||||| .. |        . |..||   ..      ..||. ||  .||.|| .  || .  ...      ..||||| || ..  |. | .|  .
vldilwsdpkakeGc.......kpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkk......vltifsasnyyeeGsnrGayvklgk

NVM
...
dlt
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 137-176 5.2e-11 35.3 In-house 24-63 (317) alignment 
Range on Protein: 137-176
Range on HMM: 24-63/317.0
LLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPAS
|. .|. ....|||||..||||||| ||. |... | | |
lfwkeplkleleapvtivGdihGqfedllalldlnGwpls
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 136-177 3.1e-07 22.8 In-house 25-66 (339) alignment 
Range on Protein: 136-177
Range on HMM: 25-66/339.0
ALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPAST
 |.  |  .. .|||. | ||||||| ||. .... | | |.
eliwsepiflkleapicvmgdihgqfddllamldmngwplss
subfamily_YNL217W_pd Subfamily YNL217W 151-232 5e-06 19.2 In-house 12-89 (235) alignment 
Range on Protein: 151-232
Range on HMM: 12-89/235.0
VTVCGDIHGQFYDLMKLFE--VGGSPASTKYLFLGDYVDRGYFSIECVLYLwslkitYPQTLFLLRGNHECRHLTEYFTFKQEC
. | ||.|| . .|..|..  .||       ...|| ...|  |.| | |.        .    ..||||   | .|   |.. 
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpk