Gene Pgam5-2 in Drosophila melanogaster

Synonym: CG15874, Dmel\CG15874, dPGAM5-2, Dmel_CG15874, Pgam5-2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PGAM5
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP109_AA protein Get Run
DmelP109_AA_77-268 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PGAM5_pd Subfamily PGAM5 79-265 2.7e-93 302.4 In-house 2-188 (189) alignment 
Range on Protein: 79-265
Range on HMM: 2-188/189.0
RHIILVRHGEYTRTPNG--SHLTELGRRQAERTGQRLREMGLSWDHVVASTMPRAEETAMIILKQLNLDPLKMKrCTLLPEGTPYPGDPPSKRSaRSLDL
||.||||||.|... .   ..||||||||||.||.||.|..|.....|||||.||.|||.||.|||. .| |.| ..|| ||.|....|..|.. ....|
rhlilvrhgqyvldddsdkkiltelGrrqaeltGkrlkelnlkftklvastmvravetadiiskqlpdvpkktk.tellreGaPikpePavkhw.kpeal

AYQRDGPRIEAAFRRYFFRASPEQEHDSYLLIVGHSNVIRYLILRALQLPPAAWTRLNLNHGSITWLTVWPSGYVTLRCLGDSGFMPVT
....||.|||||||.||.||||||..||| |||.|.||||||..|||||||.||.||.||.||||.|...|||.|.||.|||.||.|..
qfyedgarieaafrkyfhraspeqkedsyelivchanvirylvcralqlPpeawlrlslnngsitklsirPsGrvslrelGdvgflPae
0043909 Phosphoglycerate mutase-like 79-265 7.7e-38 122.7 In-house 3-243 (249) alignment 
Range on Protein: 79-265
Range on HMM: 3-243/249.0
RHIILVRHGEYTRTPN-------GSHLTELGRRQAERTGQRLREMGLSWDHVVASTMPRAEETAMIILKQLNLDPLKMKRCTLLPEG-------------
....|||||| .   .        |.||||||.||...|..|.|.|...|.|..|.. || .|| |||..|.|| |.....  | |              
krlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkaei

------------------------------------------TPYPGDPPSkrsARSLDLAYQRDGPRIEAAFRRYFfraspeqEHDSYLLIVGHSNVIR
                                          .|.   ||    . ||   ..|  | .|  ..|.         .....|||.|..|.|
aekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppg...gEsladvvaRvlpaleellarll.......kdggnvliVaHggvlr

YLILRALQLPPAAWTRLNLNHGSITWLTVWPSGY--VTLRCLGDSGFMPVT
.|. ..|.|..... ||||..||||.|.. ..|.  |.|..|.| .... .
allayllglsledilrlnlpngsitvlelddggkpvvvlvllndtshleal
0036777 Phosphoglycerate mutase-like 79-268 2.3e-37 121.3 In-house 3-241 (247) alignment 
Range on Protein: 79-268
Range on HMM: 3-241/247.0
RHIILVRHGEYTRTP-------NGSHLTELGRRQAERTGQRLREMGLSWDHVVASTMPRAEETAMIILKQLNLDPLKMKRCTLLPEG-------------
....|||||| .            ..||||||.||...|..|.|.|| .|.|..|.. || .|| |||..|.|. |.....  | |              
krlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkaei

-------------TPYPGDPPSK----------------------RSARSLDLAYQrdgpRIEAAFRRYFFRASpeqEHDSYLLIVGHSNVIRYLILRAL
              ||. .||                          . ||   ..    |...|..... |.     .....|.|.|..|.|.|. ..|
aekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvva....Rvlpaleellarll...kdgenvlvVsHggvlrallayll

QLPPAAWTRLNLNHGSITWLTVWPSGY-VTLRCLGDSGFMPVTEIT
.|..... ||||..||||.|.. ..|. ..|..|.| ....... .
glsledilrlnlpngsitvleldddgklwvleslndtshlelglea
0051064 Phosphoglycerate mutase-like 79-262 4.7e-35 114.0 In-house 4-236 (241) alignment 
Range on Protein: 79-262
Range on HMM: 4-236/241.0
RHIILVRHGEYTRTPN-------GSHLTELGRRQAERTGQRLREMGLSWDHVVASTMPRAEETAMIILKQLNLDPLKMKRCTLLPEG-------TPYP--
....|||||| .   .        ..||||||.||...|.||...|...|.|..|.. || .|| ||...|.|. |... .  | |         ...  
krlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltleei

----GDPPSKRSARSLDLAYQ------------------------RDG-------PRIEAAFRRYFFRASpeqEHDSYLLIVGHSNVIRYLILRALQLPP
    ..   ..  ..|| ..                          .|        |...|..... |.     .....|.|.|..|||.|. ..|.||.
aekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarll...ldgknvlvVsHggvirallayllglpl

AAWTRLNLNHGSITWLTVWPSG-YVTLRCLGDSGFM
... ||||..||.|.|.. ..|  |.|..|.| ...
eellrlnlpngsvtvleldddgkrvvlvllndtshl
0037864 Phosphoglycerate mutase-like 78-257 1.3e-34 111.8 In-house 7-208 (211) alignment 
Range on Protein: 78-257
Range on HMM: 7-208/211.0
LRHIILVRHGEYTRTPN-------GSHLTELGRRQAERTGQRLREMGLSWDHVVASTMPRAEETAMIILKQLNLDPLKMKRCTLLPE-------------
 ....|||||| .   .       ...||||||.||...|..|...||..|.|..|.. || .|| |||..|.|. |.....  | |             
mtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgalegltlee

GTPYPGDPPSKRSARSLDLAYQrDG-------PRIEAAFRRYFFRAspeQEHDSYLLIVGHSNVIRYLILRALQLPPAAWTRLNLNHGSITWLTVWPsGY
   . .. . .. ....| ..  .|        |...|..... |.   .......|.|.|..|.|.|. ..|.|..... ||||..||.|.|.. . | 
iaekypeelvawlrdpydfrpp.ggEsladvvaRvlpaleellarl...lkdgenvlvVsHggvlrallayllglsleellrlnlpngsvtvleldd.gg

VTLRCLG
..|..|.
wvlvsln
0048955 Phosphoglycerate mutase-like 81-264 1.5e-33 109.1 In-house 3-230 (240) alignment 
Range on Protein: 81-264
Range on HMM: 3-230/240.0
IILVRHGEYTRTPN-------GSHLTELGRRQAERTGQRLREMGLSWDHVVASTMPRAEETAMIILKQLNLDPLKMKRCTLLPEG-------TPYP----
..|||||| .   .        ..||||||.||...|.||...|. .|.|..|.. || .|| ||...|.|. |..  .  | |         ...    
lyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeiae

--GDPPSKRSARSLDLAYQ------------------------RDG-------PRIEAAFRRYFFRASPeqeHDSYLLIVGHSNVIRYLILRALQLPPAA
  ..   .. ...|| ..                          .|        |..||..... ||     .... |.|.|..|||.|. ..|.||...
kfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralk...pgknvlvVsHggvirallayllglplee

WTRLNLNHGSITWLTVWPSgyvtLRCLGDSGFMPV
..|||...||.|.|.. ..    |..|.|  ....
ilrlnipngsvtvlelddg....lvslndtshldd
0039931 Phosphoglycerate mutase-like 80-267 3e-33 107.4 In-house 1-196 (219) alignment 
Range on Protein: 80-267
Range on HMM: 1-196/219.0
HIILVRHGEYTR-----TPNGSHLTELGRRQAERTGQRLREMGLSWDHVVASTMPRAEETAMIIlkqlnldPLKMKRCTLLPEG-------------TPY
...|||||| .         .|.|||.||.||...|.||...||..|.|..|.. || .|| ||       .|.....  | |                .
rlyLvRHGetewnvegrlqgdspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii.......glpveidprLrEidfgdlegltleeiaek

PGDPPSKRSARSLDLAYQR----------DGPRIEAAFRryffraspeqehDSYLLIVGHSNVIRYLILRALQLPPAAWTRLNLNHGSITWLTVWPsGYV
 ..   .. ....| .. .            | .|. ..            .. .|.|.|..|||.|. ..|.|..... ||||..||.|.|.. . | .
ypeelaawlrdpydyrppggEsladvvaRvlpaleella............genvlvVsHggvirallayllglsleeilrlnlpngsvtvleldd.ggw

TLRCLGDSGFMPVTEI
.|..|.. .... .. 
vlvllnltshlddllr
0049178 Phosphoglycerate mutase-like 79-262 3.7e-33 107.5 In-house 4-232 (243) alignment 
Range on Protein: 79-262
Range on HMM: 4-232/243.0
RHIILVRHGEYTR-------TPNGSHLTELGRRQAERTGQRLREMGLSWDHVVASTMPRAEETAMIILKQLNLDPLKMKRCTLLPEG-------------
....|||||| .        .   |.||||||.||...|..|.|.|| .|.|..|.. || .|| |||..|.|. |.....  | |              
trlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltkaei

-----------------TPYPGDPPSK----------------RSARSLDLAYQrdgpRIEAAFRRYFFRASpeqEHDSYLLIVGHSNVIRYLILRALQL
                 ...|   ...                  . ||.  ..    |...|..... ...    ... .|.|.|..|||.|. ..|.|
aakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaa....Rvlpaleellaell...hdgktvlvVaHggvirallalllgl

PPAAWTRLNLNHGSITWLTVwPSGYVTLRCLGDSGFM
|.... ||||..||.|.|.. ..| ..|..|.| ...
pleellrlnlpngsvtvlel.ddggwvlvslndtshl
0035570 Phosphoglycerate mutase-like 81-266 5.7e-33 106.6 In-house 2-197 (219) alignment 
Range on Protein: 81-266
Range on HMM: 2-197/219.0
IILVRHGEYT-----RTPNGSHLTELGRRQAERTGQRLREMGLSWDHVVASTMPRAEETAMIIlkqlnldPLKMKRCTLLPEG-------------TPYP
..|||||| .     |  . ..|||.||.||...|..|...|. .|.|..|.. || .|| ||        |.....  | |                . 
lyLvRHGetewnlegrlqgdvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii.......glpveidprLrEidfgdlegltldeiaeky

GDPPSKRSARSLDLAYQRDG------PRIEAAFRRYffraspeqEHDSYLLIVGHSNVIRYLILRALQLPPAAWTRLNLNHGSITWLTVWPSG-YVTLRC
..   .. ....| .. .         |...|....        |... .|.|.|..|||.|. ..|.||.....||||..||.|.|.. ..| ...|..
peelaawlrdpydyrppggEsladvvaRvlpaleel........edgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggggkwvlvl

LGDSGFMPVTE
|.| ..... .
lndtshlelll
0036887 Phosphoglycerate mutase-like 79-262 5.7e-32 103.3 In-house 2-201 (202) alignment 
Range on Protein: 79-262
Range on HMM: 2-201/202.0
RHIILVRHGEYTRTPN-------GSHLTELGRRQAERTGQRLRemGLSWDHVVASTMPRAEETAMIILKQLNLDPLKMKRC----------TLLPEGTPY
....|||||| .  ..       ...||||||.||...|.||.  || .|.|..|.. || .|| ||...|.|..  ..|             |.|   .
trlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealglpvivdprlrEidfgalegltleeiaek

PGDPPSKRSARSLDLA----------YQRDGPRIEAAFRRYffraspeqeHDSYLLIVGHSNVIRYLILRALQLPPAAWTRLN-LNHGSITWLTVwPSGY
 ..   .. ....| .          ..|  . .|. ..|.         ... .|.|.|..|.|.|. ..|.|......||. |..||.|.|.. ..| 
ypeelaawlrdpydfrppggEsladvvaRvlaaleellarl.........dggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlel.ddgg

VTLRCLGDSGFM
..|..|.| ...
wvlvllndtshL
0053607 Phosphoglycerate mutase-like 79-251 5.1e-30 96.8 In-house 2-183 (191) alignment 
Range on Protein: 79-251
Range on HMM: 2-183/191.0
RHIILVRHGEYTRT-----PNGSHLTELGRRQAERTGQRLREMGLSWDHVVASTMPRAEETAMIIlkqlNLDPLKMKRC----------TLLPEGTPYPG
....|||||| .         ...||||||.||......|.|.||..|.|..|.. || .|| ||    .|..  ..|             | |   . .
trlyLvRHGetewnaegrlqgdvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii....glpvevdprlrEidfgdwegltleelaekyp

DPPSKRSARSLDLAYQRDGPRIEAAFRRYFFRASPEQehDSYLLIVGHSNVIRYLILRALQLPPAAWTRLNLNHGSITWLTVWPSGYV
.   .. ...|| .. .  .  . | | . . ..  .  .. .|.|.|..|||.|. ..|.||.... ||||..||.|.|.. ..|.|
eelaawlrdpldyrppggEsladvaaRvlpaleella..ggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggwv
0050036 Phosphoglycerate mutase-like 81-247 7.7e-22 69.8 In-house 3-169 (171) alignment 
Range on Protein: 81-247
Range on HMM: 3-169/171.0
IILVRHGEYTRTP-------NGSHLTELGRRQAERTGQRLremglSWDHVVASTMPRAEETAMIILKQLNLDPLKMKRCTLLPEGTPYPG------Dpps
..|||||| .            . ||||||.||...|..|     ..|.|..|.. || .|| .|| .. .||  . |.    || ..        .   
lyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelillpvivdprLrErdfGawegltldeiaakype...

krsaR--SLDLAYQRDG-------PRIEAA----FrryffraspeqehdSYLLIVGHSNVIRYLILRALQLPPAAWTRLNLNHGSITWLTVWP
    .   |  ..  .|        |. .|                   . .|.|.|..|||.|. ..|.|..... ||.|..||...|....
....wlldlldlappggEsladvlaRvlpaleell..............gnvlvvaHggvirallalllglsleeilrlelpngsvlvleldd
His_Phos_1 Histidine phosphatase superfamily (branch 1) 80-217 3.1e-18 59.2 Pfam-A 1-157 (158) alignment 
Range on Protein: 80-217
Range on HMM: 1-157/158.0
HIILVRHGEYT------RTPNGS-HLTELGRRQAERTGQRLREMGLSWDHVVASTMPRAEETAMIILKQLNLDPLKMKRCTLLPEGTPYpGDPPSKRSAR
...||||||         . .   .||| ||.||...|..|....| .|.|..|.. || .|| |.|..|...  | .|   .  |.   | | .. ...
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgewe.glpkeevkee

SLDL-----------------AYQRDGPRIEAAFRRYFFraspEQEHDSYLLIVGHSNVIRY
  .                   ..    |.........     .....  .|||.| .|.| 
fpeeyekwkrdkkefrppegesladvyeRvapfleelie....akdkgenvlivsHggvlra
His_Phos_1 Histidine phosphatase superfamily (branch 1) 80-217 3.1e-18 59.2 In-house 1-157 (158) alignment 
Range on Protein: 80-217
Range on HMM: 1-157/158.0
HIILVRHGEYT------RTPNGS-HLTELGRRQAERTGQRLREMGLSWDHVVASTMPRAEETAMIILKQLNLDPLKMKRCTLLPEGTPYpGDPPSKRSAR
...||||||         . .   .||| ||.||...|..|....| .|.|..|.. || .|| |.|..|...  | .|   .  |.   | | .. ...
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgewe.glpkeevkee

SLDL-----------------AYQRDGPRIEAAFRRYFFraspEQEHDSYLLIVGHSNVIRY
  .                   ..    |.........     .....  .|||.| .|.| 
fpeeyekwkrdkkefrppegesladvyeRvapfleelie....akdkgenvlivsHggvlra
0053031 Phosphoglycerate mutase-like 80-142 1.7e-10 33.9 In-house 6-91 (342) alignment 
Range on Protein: 80-142
Range on HMM: 6-91/342.0
HIILVRHGEY-------------TRTPNG-SHLTELGRRQAERTGQRLREM---------GLSWDHVVASTMPRAEETAMIILKQL
 |.|||||.              . .| | ..||.|||.||  .|.|||..           .  .| .|...|. ..|. .|. |
vivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqaflaGl
0049059 Phosphoglycerate mutase-like 79-142 2.8e-10 32.8 In-house 45-147 (435) alignment 
Range on Protein: 79-142
Range on HMM: 45-147/435.0
RHIILVRHGEYT--------------------RTPNGS--------------HLTELGRRQAERTGQRLRE-----MGLSWDHVVASTMPRAEETAMIIL
. ..|.|||. |                    ..|||.              .||.|||.|| ..|.|||.     .  .  .| .|...|. ..|.  |
qvqvlfRHGaRtPtsklikklealwekllslltypngplsflndwnyplgageLTplGreqayelGkrlrkrYgfLynpdevyvrssdvdRtlqSaqafl

KQL
. |
aGl
subfamily_TIGAR_pd Subfamily TIGAR 81-144 4.2e-10 31.7 In-house 3-71 (222) alignment 
Range on Protein: 81-144
Range on HMM: 3-71/222.0
IILVRHGE--YT--R---TPNGSHLTELGRRQAERTGQRLREMGLswDHVVASTMPRAEETAMIILKQLNL
.|.|||||  .   .    .  . |.| |..||.|...|| ....  .....|   ||..|| ||||.|. 
livVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsneki..nyifsSdllRAkqTaeiilkalke
0047369 Phosphoglycerate mutase-like 78-142 5.6e-10 32.1 In-house 45-148 (438) alignment 
Range on Protein: 78-142
Range on HMM: 45-148/438.0
LRHIILVRHGE--------------------YTRTPNGS--------------HLTELGRRQAERTGQRLREM----GLSWD-HVVASTMPRAEETAMII
   ..|.|||.                    .|  |.|.              .||.|||.||   |.|||..      ..  .| .|...|. ..|.  
kqvqvlfRHGaRtPtksklkkleplwellenattypsgplsflndwlgpcgagqLTplGreqayelGkrlrkrYglLnpedvlyvrssdvdRtlqSAqaf

LKQL
|. |
laGl
subfamily_PGAM_pd Subfamily PGAM 81-145 1.9e-09 29.2 In-house 3-74 (248) alignment 
Range on Protein: 81-145
Range on HMM: 3-74/248.0
IILVRHGEYTRTPNG-------SHLTELGRRQAERTGQRLREMGLSWDHVVASTMPRAEETAMIILKQLNLD
..|.|||| .   .         .|.| |...|...|. |.. .|. | |..|.. || .|. .||..|.  
lvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqe
0046349 Phosphoglycerate mutase-like 81-142 2e-09 30.2 In-house 11-103 (409) alignment 
Range on Protein: 81-142
Range on HMM: 11-103/409.0
IILVRHGEYTR-----------------TPNG-SHLTELGRRQAERTGQRLREM----GL---------SWDHVVASTMPRAEETAMIILKQL
..|.|||. |                   | | ..||.|||.|| ..|.|||..    ||         .  .|..|...|. ..|. .|. |
qvlfRHGaRtPtkklsflpnwpginwtngpcgagqLTplGreqayelGkrlrkrYvdlgLlpsnslynpdeiyvrssdvdRtlqSAqaflaGl
0049226 Phosphoglycerate mutase-like 80-143 4.9e-09 29.0 In-house 6-92 (342) alignment 
Range on Protein: 80-143
Range on HMM: 6-92/342.0
HIILVRHGEYT--------------RTPNGSHLTELGRRQAERTGQRLRE---------MGLSWDHVVASTMPRAEETAMIILKQLN
 ..|.|||. |               . . ..||.|||.||   |.|||.         .  .  .| .|...|. ..|. .|. | 
vqvliRHGdRtPlakgpldflnewfwgcglgeLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSaqaflaGlf
0048439 Phosphoglycerate mutase-like 81-142 8.4e-09 28.3 In-house 13-106 (391) alignment 
Range on Protein: 81-142
Range on HMM: 13-106/391.0
IILVRHGEYTRT------------------PNG-SHLTELGRRQAERTGQRLREM-------------GLSWDHVVASTMPRAEETAMIILKQL
..|.|||. | |                  | | ..||.|||.|.  .|.|||..               |  .| .|...|. ..|.  |. |
qvlfRHGaRtPtssypnkldpllnkllpngpcglgeLTplGreqlyelGrrlrkrYvdlgllpskytlnpsevyvrssdvdRtlqSAqaflaGl
0048946 Phosphoglycerate mutase-like 81-142 2.2e-08 26.5 In-house 45-155 (447) alignment 
Range on Protein: 81-142
Range on HMM: 45-155/447.0
IILVRHGEYTRT-------------------------------PNG------------SHLTELGRRQAERTGQRLREM------GLSWDHVVASTMPRA
..|.|||. | |                                .             . ||.|||.|.   |.|||..        |  .| .|...|.
qvlfRHGaRtPtkkylkgleplldllknanvlelggdlsflndwkyqlkneplwpcglgqLTplGreqlyelGkrlrkrYlgllpnpseiyvrssdvdRt

EETAMIILKQL
 ..|.  |. |
lqSaqaflaGl
subfamily_STS_pd Subfamily STS 92-145 6e-08 24.4 In-house 49-101 (245) alignment 
Range on Protein: 92-145
Range on HMM: 49-101/245.0
TPNGSHLTELGRRQAERTGQRLREMGLSWDHVVASTMPRAEETAMIILKQLNlD
  . . ||| |  ||. .|..|.| |.  .|...| . |  .||  |||.|. .
yksDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglg.k