Gene CG13604 in Drosophila melanogaster

Synonym: Dmel\CG13604, UBASH3A, Dmel_CG13604, CG13604

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily STS
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP110_AA protein Get Run
DmelP110_AA_490-737 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_STS_pd Subfamily STS 492-738 1.6e-97 317.7 In-house 1-245 (245) alignment 
Range on Protein: 492-738
Range on HMM: 1-245/245.0
RKIYIMRHGERVDFTFGTWIPyCFDeFGNYMRKDLNMPKTLPRRKNSPEGWQNDSPLTNVGVYQANLIGQALLEAQVQIDHVYCSPSYRCIQTCTSALEG
|.|||.|||||||..||.|.. .||  |.|.|||||.||.||||.........|.|||..||.||.|.|.|||||...|.|..||||.|||||..  |.|
rtiyivRhgeRvdevfgkWlk.sfd.egkyerkdlnlpkelprrpdglkdyksDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkg

LKltGKQKIKLEPGLFEWMAWYPSGVPDWLTKNELTEAKFDVDLDYEPVQPASELTArlKESTEQFYERNHDVILQLLEQT--TGNILVVAHATTLDTCS
|.   | |||.||||.||...... .|..|...||.......|.||.||.. |||..  |||.|..||| ..|. ...|..  .||||.||||.|||..|
lg..kkikikvepgllewlkldrkpipellspeelkkffpqidedYkpvlslselks..keseeelyeRikkvvkeiiekvpedgniliVahaatldals

RQLTGGVPRSTNELRQVIHKIPYCSLATVE--QVDGVWKLVEPECLPVTHS
|||.|. ||....|.....|.||||||..|  . .. |||.....|....|
rqllglspresedlkklvikspycslakleenkeerkwkltdsgilsllks
subfamily_Cele-STS-like_pd Subfamily Cele-STS-like 494-738 5.2e-49 157.6 In-house 2-229 (229) alignment 
Range on Protein: 494-738
Range on HMM: 2-229/229.0
IYIMRHGERVDFTFGTWIPyCFDEFGNYMRKDLNMPKTLPRRKnspEGWQNDSPLTNVGVYQANLIGQALLEAQVQIDHVYCSPSYRCIQTCTSALEGLK
. ..|..||||. || ||   .|  . |   |.|.||.||.|    .... |.|||..| ....||| ||... ... .|.|||  |..|| .  |.|| 
vvvirsaervdevfgkWik.sadletkyrpldinvPkelpkra...ksykldpPlteiGkiaskligRaLrdrgiepsvvFCSPdlrsvqtaalllkglG

LtGKQKIKLEPGLFEwmawYPSGVPDWLTKNELTEAKFDVDLDYEPVqpaseLTARLKESTEQFYERNHDVILQLLEQTT-GNILVVAHATTLDTCSRQl
|  . .|..||||.|    |    . .|. .....  . || .| |.        . .||...|..| . .. .||.. . ..|||||....|... |. 
l.kraaisvePgLle....yrkarevllppkafkklgypvdekYkPl.....kelsmaeslsdfvariqaafkkllskveqklilvvadnvsleltrre.

tggVPRSTNELRQVIHKIPYCSLATVEQVDGVWKLVEPECLPVTHS
     .|...| ....| |..|.  |.  .| ...|.   |....|
...dvesvddllvllkktpalsvvivnlkkGearivdspvlllsks
0051064 Phosphoglycerate mutase-like 492-728 8.7e-36 116.4 In-house 4-228 (241) alignment 
Range on Protein: 492-728
Range on HMM: 4-228/241.0
RKIYIMRHGERVDFTFGTWIPycfdefgnymrkdlnmpktlprrknspegwQNDSPLTNVGVYQANLIGQALLEAQVQIDHVYCSPSYRCIQTCTSALEG
...|..||||... . | .                                . |.|||  |. ||  .|..| ......|.||.||  |.|||.  ..|.
krlyLvRHGesewnaegrlqg..............................wtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaea

LKLTgKQKIKLEPGLFEWMAWYPSGVPDWLTKNELTEAKFDVDLDYEPVQPAS-------------------ELTARLKESTEQFYERNHDVILQLLEQ-
|.|. . .....|.| |.   .  | . . ..... |. . .. |   |.|                     . .    || .....| .... .||.. 
lglp.llpvvvdprlrEidfgalegltleeiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarl

--TTGNILVVAHATTLDTCSRQLTGgvpRSTNELRQVihKIPYCSLATVEQVDG--VWKLV
    .|.|||.|. .. .. ..|.|   .. .||...  ..|..|. ..|  |.  ...||
lldgknvlvVsHggvirallayllg...lpleellrl..nlpngsvtvleldddgkrvvlv
0048955 Phosphoglycerate mutase-like 493-727 1.3e-35 115.8 In-house 2-222 (240) alignment 
Range on Protein: 493-727
Range on HMM: 2-222/240.0
KIYIMRHGERVDFTFGTWIPycfdefgnymrkdlnmpktlprrknspegwQNDSPLTNVGVYQANLIGQALLEAQVQIDHVYCSPSYRCIQTCTSALEGL
..|..||||... ..| .                                . |.|||  |. ||  .|..| ......|.||.|| .|.|||.  ..|.|
rlyLvRHGesewnaegrlqg..............................wtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaeal

KLTGkQKIKLEPGLFEWMAWYPSGVPDWLTKNELTEAKFDVDLDYEPVQPAS-------------------ELTARLKESTEQFYERNHDVILQLLEQ--
.|    .. ..|.| |.  ..  | .   ..... |. . .  |   | |                     | .    || .....| .... .||..  
glpl.lpvvvdprlrErdfgalegltldeiaekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaral

-TTGNILVVAHATTLDTCSRQLTGgvpRSTNELRQVihKIPYCSLATVEQVDGVWKL
 ...|.|||.|. .. .. ..|.|   .. .|....  .||..|. ..|  ||.. |
kpgknvlvVsHggvirallayllg...lpleeilrl..nipngsvtvlelddglvsl
0037864 Phosphoglycerate mutase-like 491-728 8.4e-35 112.4 In-house 7-205 (211) alignment 
Range on Protein: 491-728
Range on HMM: 7-205/211.0
NRKIYIMRHGERVDFTFGTWIpycfdefgnymrkdlnmpktlprrknspeGWqNDSPLTNVGVYQANLIGQALLEAQVQIDHVYCSPSYRCIQTCTSALE
 ...|..||||... . | .                              ||  |.||| .|. || ..|.|| ......|.||.|| .|.|||.  .||
mtrlyLvRHGetewnaegrlq.............................gw.ldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiile

GLKLTgKQKIKLEPGLFEWMAWYPSGVPDWLTKNELTEAKFDVDLDYEPVQPASEltarlkESTEQFYERNHDVILQLLEQ---TTGNILVVAHATTLDT
.|.|  . .....|.| |.  .. .| .   ....  |. .    |.  ..|         || .....| .... .||..     .|.|||.|...| .
alglp.llpvevdprlrErdfgalegltleeiaekypeelvawlrdpydfrppgg......EsladvvaRvlpaleellarllkdgenvlvVsHggvlra

CSRQLTGGVPRSTNELrqvihKIPYCSLATVEQVDGVWKLV
. ..|.|  .    .|     ..|..|....|  || |.||
llayllglsleellrl.....nlpngsvtvlelddggwvlv
0043909 Phosphoglycerate mutase-like 492-734 2e-34 111.5 In-house 3-235 (249) alignment 
Range on Protein: 492-734
Range on HMM: 3-235/249.0
RKIYIMRHGERVDFTFGTWipycfdefgnymrkdlnmpktlprrknspeGWQNDSPLTNVGVYQANLIGQALLEAQVQIDHVYCSPSYRCIQTCTSALEG
...|..|||| .. . | .                                . |||||  |. || ..|.|| |.....|.||.|| .|.|||.  .||.
krlyLvRHGetewnaegrf..............................qgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiilee

LKLTGkQKIKLEPGLFE------------------------WMAWYPSGVPDWLTKNELTEAKFDVDLDYEPVQPASELTARlKESTEQFYERNHDVILQ
|.|.   ... .|.| |                        |...  . .| .|... .. .....|. . .. | .    .  || .....| .... .
lgldk.lpvevdprLrErdfGalegltkaeiaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppg.gEsladvvaRvlpalee

LLEQ---TTGNILVVAHATTLDTCSRQLTGGVPRSTNELrqvihKIPYCSLATVEQVDGVWKLVEPECLP
||..     ||.|.|||. .| .. ..|.|  ..   .|     ..|..|. ..|  || ...|  ..| 
llarllkdggnvliVaHggvlrallayllglsledilrl.....nlpngsitvlelddggkpvvvlvlln
0036777 Phosphoglycerate mutase-like 492-728 1.8e-33 108.5 In-house 3-227 (247) alignment 
Range on Protein: 492-728
Range on HMM: 3-227/247.0
RKIYIMRHGERVDFTfgtwipycfdefgnymrkdlnmpktlprrKNSPEGWqNDSPLTNVGVYQANLIGQALLEAQVQIDHVYCSPSYRCIQTCTSALEG
...|..|||| .. .                              .   ||  |.|||  |. || ..|..| |.....|.||.|| .|.|||.  .||.
krlyLvRHGetewna.............................egrfqgw.lDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilea

LKLTgKQKIKLEPGLFEWMAWYPSGVPDWLTKNELTEAKFDVDLDYEPVQP-------------------ASELTARLKESTEQFYERNHDVILQLLEQ-
|.|  . ... .|.| |.   .  | .   ....  |. .    |  .. |                       ..   || .....| .... .||.. 
lgls.llpvvvdprLrErdyGalegltkaeiaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarl

--TTGNILVVAHATTLDTCSRQLTGGVPRSTNELrqvihKIPYCSLATVEQVDGV--WKLV
    .|.|||.|...| .. ..|.|  .    .|     ..|..|. ..|  |.   |.|.
lkdgenvlvVsHggvlrallayllglsledilrl.....nlpngsitvleldddgklwvle
0036887 Phosphoglycerate mutase-like 492-729 1.1e-32 105.6 In-house 2-194 (202) alignment 
Range on Protein: 492-729
Range on HMM: 2-194/202.0
RKIYIMRHGERVDFTFGTWIPycfdefgnymrkdlnmpktlprrknspegwQNDSPLTNVGVYQANLIGQALLeaQVQIDHVYCSPSYRCIQTCTSALEG
...|..||||... . | ..                               . |.|||  |. ||  .|..|.  ....|.||.|| .|.|||.  ..|.
trlyLvRHGetewnvegrlqg..............................dldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaea

LKltgkQKIKLEPGLFEWMAWYPSGVPDWLTKNELTEAKFDVDLDYEPVQPASEltarlkESTEQFYERNHDVILQLLEQ-TTGNILVVAHATTLDTCSR
|.     .....|.| |.  .. .|..   ....  |. ..   |.  . |         || .....| .... .||..   ||.|||.|...| .. .
lg....lpvivdprlrEidfgalegltleeiaekypeelaawlrdpydfrppgg......EsladvvaRvlaaleellarldggnvlvVsHggvlralla

QLTGGVPRSTNELRqvihKIPYCSLATVEQVDGVWKLVE
.|.|  .     ||    |.|..|. ..|  || |.|| 
yllglsledllrlr....klpngsvtvlelddggwvlvl
His_Phos_1 Histidine phosphatase superfamily (branch 1) 493-688 1.7e-32 105.5 Pfam-A 1-158 (158) alignment 
Range on Protein: 493-688
Range on HMM: 1-158/158.0
KIYIMRHGERVdftfgtwipycfdefgnymrkdlnmpktlPRRKNSPEGWQNDsPLTNVGVYQANLIGQALLEAQVQIDHVYCSPSYRCIQTCTSALEGL
..|..||||..                              ..... .||... |||. |  ||. .|..| .|...||.||.||..|.|||... ||.|
rlylvRHGese.............................wnkegrlqgwsdv.pLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleel

KltgkQKIKLEPGLFEWMA--WyPsGVPDWLTKNELTEAKFDVDLDYEPVQPAseltarLKESTEQFYERNHDVILQLL--EQTTGNILVVAHATTLDTC
.     .|. ||.| |...  |   | | . .|.|. |..   . |.....|        .|| ...||| .... .|.  .....|.|.|.|...|...
d....ipiikeprLrerdfgew.e.glpkeevkeefpeeyekwkrdkkefrpp......egesladvyeRvapfleelieakdkgenvlivsHggvlral
His_Phos_1 Histidine phosphatase superfamily (branch 1) 493-688 1.7e-32 105.5 In-house 1-158 (158) alignment 
Range on Protein: 493-688
Range on HMM: 1-158/158.0
KIYIMRHGERVdftfgtwipycfdefgnymrkdlnmpktlPRRKNSPEGWQNDsPLTNVGVYQANLIGQALLEAQVQIDHVYCSPSYRCIQTCTSALEGL
..|..||||..                              ..... .||... |||. |  ||. .|..| .|...||.||.||..|.|||... ||.|
rlylvRHGese.............................wnkegrlqgwsdv.pLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleel

KltgkQKIKLEPGLFEWMA--WyPsGVPDWLTKNELTEAKFDVDLDYEPVQPAseltarLKESTEQFYERNHDVILQLL--EQTTGNILVVAHATTLDTC
.     .|. ||.| |...  |   | | . .|.|. |..   . |.....|        .|| ...||| .... .|.  .....|.|.|.|...|...
d....ipiikeprLrerdfgew.e.glpkeevkeefpeeyekwkrdkkefrpp......egesladvyeRvapfleelieakdkgenvlivsHggvlral
0049178 Phosphoglycerate mutase-like 492-737 1.5e-30 99.0 In-house 4-233 (243) alignment 
Range on Protein: 492-737
Range on HMM: 4-233/243.0
RKIYIMRHGERVDFTFGTWIPycfdefgnymrkdlnmpktlprrknspegwQNDSPLTNVGVYQANLIGQALLEAQVQIDHVYCSPSYRCIQTCTSALEG
...|..|||| .  . | .                                . |||||  |. || ..|..| |.....|.||.||  |.|||.  .||.
trlyLvRHGetewnaegrlqg..............................wtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilea

LKLTGkQKIKLEPGLFEWMAWYPSGVPDWLTKNELTEAKFDVDLDYEPVQP-----------------ASELTARLKESTEQFYERNHDVILQLLEQ---
|.|.   .....|.| |.   .  | .   .. .  |. .    |.  ..|                 |.  .    || .....| .... .||..   
lglpl.lpvvvdprLrErdfGalegltkaeiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellh

TTGNILVVAHATTLDTCSRQLTGGVPRSTNELRqvihkIPYCSLATVEQVDGVWKLVEPECLPVTH
. ...|||||  .. .  ..|.|  .     |.     .|..|. ..|  || |.||   ......
dgktvlvVaHggvirallalllglpleellrln.....lpngsvtvlelddggwvlvslndtshld
0035570 Phosphoglycerate mutase-like 493-728 2.3e-29 94.9 In-house 1-185 (219) alignment 
Range on Protein: 493-728
Range on HMM: 1-185/219.0
KIYIMRHGERVDFTfgtwipycfdefgnymrkdlnmpktlprrknsPEGWQNDSPLTNVGVYQANLIGQALLEAQVQIDHVYCSPSYRCIQTCTSAlegl
..|..||||... .                                .  .|.|.|||  |. ||  .|.|| . ....|.||.|| .|.|||.  .    
rlyLvRHGetewnl................................egrlqgdvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii....

kltgKQKIKLEPGLFEWMAWYPSGVPDWLTKNELTEAKFDVDLDYEPVQPaseltaRLKESTEQFYERNHDVILQLleQTTGNILVVAHATTLDTCSRQL
    . .....|.| |. . . .| .   ....  |. . .  |   . |         || .....| .... .|  .  .|.|||.|. .. .  ..|
....glpveidprLrEidfgdlegltldeiaekypeelaawlrdpydyrp......pggEsladvvaRvlpaleel..edgenvlvVsHggvirallayl

TGGVPRSTNELRqvihkIPYCSLATVEQVDGV--WKLV
.|  .     |.     .|..|. ..|  .|   |.||
lglpleeilrln.....lpngsvtvleldggggkwvlv
0039931 Phosphoglycerate mutase-like 493-730 3.5e-29 94.2 In-house 1-185 (219) alignment 
Range on Protein: 493-730
Range on HMM: 1-185/219.0
KIYIMRHGERVDFTfgtwipycfdefgnymrkdlnmpktlprrknsPEGWQNDSPLTNVGVYQANLIGQALLEAQVQIDHVYCSPSYRCIQTCTSAlegl
..|..|||| .. .                                .  .| |||||  |. ||  .|..| . ....|.||.|| .|.|||.  .    
rlyLvRHGetewnv................................egrlqgdspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii....

kltgKQKIKLEPGLFEWMAWYPSGVPDWLTKNELTEAKFDVDLDYEPVQPaseltaRLKESTEQFYERNHDVILQLLEqtTGNILVVAHATTLDTCSRQL
    . .....|.| |. . . .| .   ....  |. .    |.  . |         || .....| .... .||.   .|.|||.|.... .  ..|
....glpveidprLrEidfgdlegltleeiaekypeelaawlrdpydyrp......pggEsladvvaRvlpaleella..genvlvVsHggvirallayl

TGGVPRSTNELrqvihKIPYCSLATVEQVDGVWKLVEP
.|  .     |     ..|..|. ..|  || |.||  
lglsleeilrl.....nlpngsvtvlelddggwvlvll
0053607 Phosphoglycerate mutase-like 538-729 8.4e-24 76.6 In-house 16-186 (191) alignment 
Range on Protein: 538-729
Range on HMM: 16-186/191.0
SPEGWQNDSPLTNVGVYQANLIGQALLEAQVQIDHVYCSPSYRCIQTCTSAleglkltgKQKIKLEPGLFEWMAWYPSGVPDWLTKNELTEAKFDVDLDY
    .| |.|||  |. || .....| | ....|.||.||  |..||.  .        . .....|.| |. . .  | .   ..... |. .    |.
aegrlqgdvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii........glpvevdprlrEidfgdwegltleelaekypeelaawlrdp

EPVQPaseltaRLKESTEQFYERNHDVILQLLEqtTGNILVVAHATTLDTCSRQLTGGVPRSTNELRqvihkIPYCSLATVEQVDGVWKLVE
  . |         || .....| .... .||.   ||.|||||. .. .  ..|.|  .     |.     .|..|. ..|  || |.|| 
ldyrp......pggEsladvaaRvlpaleella..ggnvlvVaHggvirallayllglpleellrln.....lpngsvtvlelddggwvlvl
0050036 Phosphoglycerate mutase-like 541-694 1.8e-18 58.9 In-house 21-146 (171) alignment 
Range on Protein: 541-694
Range on HMM: 21-146/171.0
GWqNDSPLTNVGVYQANLIGQALleaqvQIDHVYCSPSYRCIQTCTSALeglkltgkQKIKLEPGLFEWMAwypsGVPDWLTKNELTEAKFDvdldyePV
||  |.|||  |. ||  .|..|     ..|.||.||  |..||.  .|         .. ..|.| |.      |. . ||..|. .   .        
gw.tdvpLtelgraqaralgell.....pfdavysSpllRArqTaelil........lpvivdprLrErdf....Gawegltldeiaakype......wl

QPASELTARLKESTEQFYERNHDVILQLLeqttGNILVVAHATTLDTCSRQLTG
.    |..   || .....| .... .||    ||.|||||. .. .  ..|.|
ldlldlappggEsladvlaRvlpaleell....gnvlvvaHggvirallalllg
subfamily_TFC7_pd Subfamily TFC7 535-693 5.7e-17 53.1 In-house 20-178 (255) alignment 
Range on Protein: 535-693
Range on HMM: 20-178/255.0
RKNSPEGWQNDSPLTNVGVYQANLIGQALLEAQVQIDHVYCSPSYRCIQTCTSALEGLKLTgkqkIKLEPGLFEWMAWY--PsGVPDWLTKNELTEAKFD
. ... | ..| ||.. || ||. ... |.. ... . ...|| |||..| ..  | |..     .... |. ||.     |  ... .....|      
ypdpltgidsdvPlserGveqakelaiylkkldlkpeaifssPlyrcletskpiaeeleiP....vyvdrGvgewykpdrrP.vilePasnevlskffPs

-VDLDYEPVQPASEltarLKESTEQFYERNH---DVILQLLEQ---TTGNILVVAHATTLDTCSRQLT
 ..||||.    ||     .|. |..||| .    | .. .|.     . ||.|.||.|  .  ..| 
visldyestltpse....kgeteeelyertkkfwpvfidrvekkfknvetilivthaatkialGmsll
SH3_9 Variant SH3 domain 278-332 7.3e-17 50.0 Pfam-A 1-49 (49) alignment 
Range on Protein: 278-332
Range on HMM: 1-49/49.0
VVYPHNPHETDELELRIGDYIYLNTEvvdsSSDGWAEGISwlTGSTGHLPVNYTE
..|...| . |||.|. ||.|..  |    ..||| .|..  || || .|.||.|
AlydyepkdddELslskGdvitvlee....tedgWllGel..tGrtGlvPanyVe
0047369 Phosphoglycerate mutase-like 494-721 8.2e-12 38.1 In-house 48-261 (438) alignment 
Range on Protein: 494-721
Range on HMM: 48-261/438.0
IYIMRHGERV--DFTFGTWIP--YCFDEFGNYMRKDLNMPKTLPrrknSPEGWqndSPLTNVGVYQANLIGQALLE-----AQVQIDHVYCSPSYRCIQT
....|||.|   .... .. |   .... ..| . .|.. ....     | |.     ||..|..||  .|. | .     .. .. .|..|.. |..|.
qvlfRHGaRtPtksklkkleplwellenattypsgplsflndwl....gpcga...gqLTplGreqayelGkrlrkrYglLnpedvlyvrssdvdRtlqS

CTSALEGLkltgkqkikLEPGLFEWMAWYPSGVPDWLTKNELTEAKFD--VDLDYEPVQPASELTARLKESTEQFYERNHDVILQLLE---QTTGNILVV
 .. | ||         ..| . .. | .   ...  | .| ..  ..   .     .. ... .. ..|  | ....  ... .||.    |. ..| .
AqaflaGl.........fppegtgelapilwqpipihtipesddfllnllpsdscpafdellkeflasdeflelllkdilkrlkkllpglnltpsdvldl

AHATTLDTCSRqltggvprstnelrQ--VIHKIPYCSLATVEQV
 .  . ||. .              .    .  |.||| | |..
ydlcaydtlan..............gyaglplspfcslftpeel
UBA UBA/TS-N domain 25-57 9.9e-11 29.7 Pfam-A 6-37 (37) alignment 
Range on Protein: 25-57
Range on HMM: 6-37/37.0
LQTLLQMGFPRHRAEKALASTGNrGVQIASDWL
.|.|. |||.|..| ||| .|.|  |. | ..|
iqqLreMGfsreeakkALratnn.nverAveyL
0049059 Phosphoglycerate mutase-like 494-724 2e-10 33.3 In-house 47-262 (435) alignment 
Range on Protein: 494-724
Range on HMM: 47-262/435.0
IYIMRHGERVDFTF----GTWIPYCFDEFGNYMRkdlnmpkTLPRRKNSPEGWQNDSPLTNVGVYQANLIGQALLE-----AQVQIDHVYCSPSYRCIQT
....|||.|            .  .. .  .| .           . |.... .... ||..|..||  .|. | .      . .  .|. |.. |..|.
qvlfRHGaRtPtsklikklealwekllslltypn.......gplsflndwnyplgageLTplGreqayelGkrlrkrYgfLynpdevyvrssdvdRtlqS

CTSALEGLklTGKQkiklepglfewmaW------YPSGVPDWLTKNEltEAKFDVDLDYEPVQPASELTARLK---ESTEQFYERNHDVILQ---LLEQT
  . |.||   . .             .      .|  | ...  ..     ..  |.| . .   ||  .|.   |  | |.||. ... .    |..|
aqaflaGl..fppe.............ilgsqllnplnvyqpvpiet..vdsdndtlpydscpafdellkellasdeflelflerilkllqellpglglt

TGNILVVAHATTLDTCSRQLTGGVPrstnelrqvihkIPYCSLATVEQVDGV
. ..| .   .  ||  .. . |.|             |.||| | |... .
psdvldlydlckydtlllgyahglp............lpfcslfteeelevl
0053031 Phosphoglycerate mutase-like 494-699 2.6e-10 33.3 In-house 7-192 (342) alignment 
Range on Protein: 494-699
Range on HMM: 7-192/342.0
IYIMRHGERV-----DFTFGTWIPYcfdefgnymrkdlnmpktlprrknspegwQN-DSPLTNVGVYQANLIGQALLEA---------QVQIDHVYCSPS
|...|||.|      ....  .  |                             .  ...||..|..||  .|..| .            .. .|. |..
ivlvRHGaRtPlskgpldplnewfy.............................pcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdv

YRCIQTCTSALEGLKltGKQKIKLEPGLFEWMAWY---PSGVPD-WLTKNELTEAKFDVDLDYEPvqpASELTARLKESTEQFYernhDVILQLLEQTTG
 |..|. .. |.||   ....... . |..|  .     . ..|  |. |  . ..||  |.  .   |||   .|.|......    . . . |..|. 
dRtlqSAqaflaGlf..ppegtpilnpllgwqpipihtepessdalllpnydpcpafdkllkeal...aseevkellerylell....qklskglgltls

NILVVaHATTLDTCSRQLTGGVPRS
. | .   .  |..  .|. | | .
dlldl.vsdlydlllyelahglplp
subfamily_TIGAR_pd Subfamily TIGAR 543-671 4e-10 31.7 In-house 22-137 (222) alignment 
Range on Protein: 543-671
Range on HMM: 22-137/222.0
QNDSPLTNVGVYQANLIGQALLeaQVQIDHVYCSPSYRCIQTCTSALEGLKLTGKQKIKLEPGLFEWMawYpsGVPDWLTKNELTEAKFDVDldyepvqP
| |.||.. || || .... |   . .|.... |.  |  ||    |. ||   ..... .. | |.   |  ||    ...|| |. .           
qtdtpLsekGveQakrvakrLs..nekinyifsSdllRAkqTaeiilkalkekkreaverdkrLrEre..y..GvyeGvaldelrellkaag.......n

ASELTARLKESTEQFYERNHDVILQLLEQ
  . .   .||.||.. |  . . .| ..
vpsfvpegGesieqlelrlvaaleelcak
0049226 Phosphoglycerate mutase-like 494-593 3e-09 29.7 In-house 7-92 (342) alignment 
Range on Protein: 494-593
Range on HMM: 7-92/342.0
IYIMRHGERVDFTFGTWI-----PycfdefgnymrkdlnmpktlprrknspeGWQNDSPLTNVGVYQANLIGQALLE---------AQVQIDHVYCSPSY
....|||.|  . .| .                                   .  ....||..|..||  .|..| .            .. .|. |.. 
qvliRHGdRtPlakgpldflnewf............................wgcglgeLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvd

RCIQTCTSALEGLK
|..|. .. | || 
RtlqSaqaflaGlf
subfamily_PGAM_pd Subfamily PGAM 536-593 1.2e-08 26.6 In-house 16-72 (248) alignment 
Range on Protein: 536-593
Range on HMM: 16-72/248.0
KNSPEGWQnDSPLTNVGVYQANLIGQALLEAQVQIDHVYCSPSYRCIQTCTSALEGLK
.|   ||  |  |.. |. .|.  |.|| .|....| ||.|   |..||..  || |.
enkfcgwv.DakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeld
0046349 Phosphoglycerate mutase-like 494-699 1.4e-08 27.5 In-house 11-231 (409) alignment 
Range on Protein: 494-699
Range on HMM: 11-231/409.0
IYIMRHGERVDFTFgtwipycfdefgnymrkdL-----------NmpktlprrknsPEGWQNdSPLTNVGVYQANLIGQALLE-------------AQVQ
....|||.|                       |                       . ...  ..||..|..||  .|..| .                .
qvlfRHGaRtPtkk..................lsflpnwpginwt...........ngpcga.gqLTplGreqayelGkrlrkrYvdlgLlpsnslynpd

IDHVYCSPSYRCIQTCTSALEGL--KLTGKQKIKLEPGLFEWMaWYPSGVPDWLTKNEltEAKFDVDLDY-EPVQPASELTARLKESTEQFYE-------
. .|. |.. |..|. .. |.||   |.|.  . | ..|.. . . |  ...  . .   .|. |. | .  . .   .|... ..| ....|       
eiyvrssdvdRtlqSAqaflaGlfpplggeivpllrqdlldpp.fqpipidtvpised..dalddtllppdslcpaldkllkenlkslsevleflvdeal

----RNHD--VILQLLEQTT----GNI----LVVAHATTLDTCSRQLTGGVPRS
     ...   .|. | . .     ..    .  ....  ||.. ..  | | .
ldlelldetkdllkklaerlnselpglnltdpldvasllydtllyetahglplp
0048946 Phosphoglycerate mutase-like 494-593 6.1e-08 25.1 In-house 45-156 (447) alignment 
Range on Protein: 494-593
Range on HMM: 45-156/447.0
IYIMRHGERV-----DFTFGTWIPYCFDEFGNYMRKDLNMPKTLPRRK-NSPEGWQNDSPLTNVGVYQANLIGQALLEA------QVQIDHVYCSPSYRC
....|||.|       ...  .. .. .  . ....||..... .    |.|..  . . ||..| .|.  .|..| .         .  .|. |.. |.
qvlfRHGaRtPtkkylkgleplldllknanvlelggdlsflndwkyqlkneplwpcglgqLTplGreqlyelGkrlrkrYlgllpnpseiyvrssdvdRt

IQTCTSALEGLK
.|. .. | || 
lqSaqaflaGlf
0048439 Phosphoglycerate mutase-like 494-608 6.8e-08 25.4 In-house 13-122 (391) alignment 
Range on Protein: 494-608
Range on HMM: 13-122/391.0
IYIMRHGERV---DFTF--GTWIPYcfdefgnymrkdlnmpktlprrkNSPEGWQNDSPLTNVGVYQANLIGQALLEA-------------QVQIDHVYC
....|||.|    ....    ....                       . | |  ....||..|..|.  .|..| .              . .. .|..
qvlfRHGaRtPtssypnkldpllnk.......................llpngpcglgeLTplGreqlyelGrrlrkrYvdlgllpskytlnpsevyvrs

SPSYRCIQTCTSALEGLKLTGKQKIKLEPGLFE
|.. |..|. .. |.||   .. .. | . . .
sdvdRtlqSAqaflaGlfpplgltvilvivves
2_5_RNA_ligase2 2'-5' RNA ligase superfamily 89-259 3e-06 15.7 Pfam-A 6-139 (153) alignment 
Range on Protein: 89-259
Range on HMM: 6-139/153.0
EEFWAKSRQMCGWNGAHNYVPHITLVSFFKAPDECsLQLSKALKQVVDmtgalldrplKLEPyMSQNFMGFFVA--EEDANYLKRlalqyvkevsnsIIS
...... |. ..  ....  |||||.  |..|..   .| ..|....           . || .   . |. |   . .. ||.               |
aapiealrrslydkayprwppHiTLlypfvepedl.qdlaellsrlaa..........etep.fevrldgvgvFehkksvvylev............sps

DTYEQL-DAIVACFPWCGAVSSGTrciprssrsislepHVKSLHLTLAYQFPQAQFnalKALVETL-DASCASNW
.. ..| .|... .| .|.... |              .    |||.|.. .....   |.|.| | .|. .  .
eslsaLraallealpeaglkedst..............geftPHlTiaqsedstsa...kelleklagalpplef
subfamily_PFKFB_pd Subfamily PFKFB 488-690 4.8e-06 18.1 In-house 3-158 (198) alignment 
Range on Protein: 488-690
Range on HMM: 3-158/198.0
HAKNRKIYIMRHGERVDFtfgtwipycfdefgnyM--------RkdlnmpktlprrknspegwqndspLTNVGVYQANLIGQALLEAQVQIDHVYCSPSY
| |.|.||..||||  .                 .                                 ||. || .|. ... . | ...  .|..|   
hlkpreiylvRhGesekn................kkgriggdse........................LterGveyakklakfikeenlkelrvwtselk

RCIQTCTSAleglKLTgKQKIKLepglfewMAWYPSGVPDWLTKNELTEaKFDVDLDYEPvQPASELTARLKESTEQFYERNHDVILQlLEQTTGNILVV
| ||| .      .|  |...|        .     |. | || .|. | ||  ...    .   .   .  || |.  .|   |||. ||..  |.|..
rtiqTaell....glp.keqwka.......LdeldaGkcdgltyeeike.kfpeefkerk.kdkyryryprgEsyedlvqRlepvile.Lereqenvlii

AHATTLDTCSR
|| ..|     
aHqavlrvlla