Gene Phlpp in Drosophila melanogaster

Synonym: CG10493, CT29458, Dmel\CG10493, PP2C, dPHLPP, Dmel_CG10493, Phlpp

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PHLPP
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP126_AA protein Get Run
DmelP126_AA_463-657 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PHLPP_pd Subfamily PHLPP 436-581 1.1e-40 132.0 In-house 5-138 (246) alignment
Range on Protein: 436-581
Range on HMM: 5-138/246.0
WTMGFAETpgSGDCRKLSVYQLraanyggSDEALYGMFEalegrGRAAQEMSHLVPDLMKQ---EQMVKDSAVRDYMKFTLLAAQQQCGS----VRSAAL
. .|..|.  .|   || | .|       |.|||||.|.     |....|.|.|...|||.   |...||.....|||.|||.||...|.    ..||||
fsiGlses..aGvknklcvaal.......svealyGlfd.....GdrneelssllqrlmkdvlkeevqkdkneeeymkntllvaqrklGeaGeklgsaal

FHLTRtraPSKVRPLKSkrYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQ
..|.|   ..||.|.||  ..|..||.|.|.|.|||....|||.|..||.||.
lilir...hdkvdPaks..fsLevAsvGtlqavliRngkklrlsksyviekde

subfamily_PHLPP_pd Subfamily PHLPP 585-656 6.9e-31 100.0 In-house 175-246 (246) alignment
Range on Protein: 585-656
Range on HMM: 175-246/246.0
MPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFR
.|.||| |..|...||.|.|||..||.|..||.|....||||..|.|||.|||.|||..||.|.||.|||.|
lPkphvrevlLteqdellivGnkalWevlsideaveavrkeedplvaAkklvdlaqsygaadsvsvlvvrlr

0034914 PP2C-like 464-657 1.6e-11 36.9 In-house 49-292 (295) alignment
Range on Protein: 464-657
Range on HMM: 49-292/295.0
GSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQ------EQMVKDSAVRDYMKFTLLAAQQQ-------------CGSVRSAALFHLTrtrapskvrplk
 .| .|.|.|    |   |   ...||  |...        .  .  ...... ..|||...             .|.  ..||.. .            
ledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallrpelagsGtTavvalirgn............

skryVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHS------------------------------------------MPDPHVLELILS-NDDEY
     | .| .|   |.|.|.   ..||.        .                                             . |.|  | |. .||..
....klyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddf

LVVGNAQLWSVMDIDRAAREIRK----EENSLLAAKRLVDIAQSFAAAESLSVIVVRFRH
|...   || |.. . ... .|.      .   ||..|||.| .  . . ..|.|||...
llLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlng

LRR_8 Leucine rich repeat 279-335 6.5e-11 31.5 Pfam-A 2-59 (61) alignment
Range on Protein: 279-335
Range on HMM: 2-59/61.0
KLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEV-ATLGQLRVLRCCNN
.|..|.|  ||. |.|  .  ... |. | |||| |. ...|. . | .|| |   .|
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgN

LRR_8 Leucine rich repeat 206-266 3e-09 26.1 Pfam-A 2-61 (61) alignment
Range on Protein: 206-266
Range on HMM: 2-61/61.0
SIRSLQLQSNELPSLPDNFFAVThARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHL
....|.|..|.| ..|...|     .|..|. |.|.|.....   ..  .|  |.| ||.|
nLkeLdLsnNrlkviptgsFkgl.snLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl

LRR_8 Leucine rich repeat 109-169 4.8e-09 25.5 Pfam-A 1-61 (61) alignment
Range on Protein: 109-169
Range on HMM: 1-61/61.0
TNLQTLVADHNYLHNISTTNTHPVpLKLQRIDISHNNFSELP-NWVGACASLTAINASHNRL
.||..|  ..| | .|.|.  .    .|. .|.|.|| .... ..   . ||. .| |.|||
pnLkeLdLsnNrlkviptgsFkgl.snLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl

LRR_4 Leucine Rich repeats (2 copies) 135-175 2.7e-08 23.2 Pfam-A 2-42 (44) alignment
Range on Protein: 135-175
Range on HMM: 2-42/44.0
KLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVL
.|. .|.|.|| ..||.... . .|. .| |.|.. .. .|
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdlsaL

LRR_8 Leucine rich repeat 327-381 1.2e-07 21.0 Pfam-A 3-59 (61) alignment
Range on Protein: 327-381
Range on HMM: 3-59/61.0
LRVLRCCNNLLLCTP--QLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGN
|..|  .|| |   |   . .|  |||||||.| | ...  |.   ..|..|.||||
LkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgN

0049733 PP2C-like 500-656 1.4e-07 24.5 In-house 59-234 (235) alignment
Range on Protein: 500-656
Range on HMM: 59-234/235.0
VKDSAVRDYMKFTLLAA-------------QQQCGSVRSAALFHlTRTrapskvrplkskryvLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIH---
     ...... ..|||              . .|.  ..||.. ...               | .|. |   |||.|.   ..||...    ...    
lllldleealrkaflaaneallelalaspelagmgtTavvalld.ggk...............lyvanvGDsrayllrdgklvqltedhspvnelerqri

---------------------SMPDPHVLELILSNDDeYLVVGNAQLWSVMDIDRAAREIRKeENSLLAAKRLVDIAQSFAAAESLSVIVVRFR
                     .. .|.| .| |...| .|..    ||.|.. . ... .|.  .   ||.|||. | .    . ..|.|||..
itaggavrvpgrlaltralGdlllkpdvtvlelepgd.flllasDGlwdvlsdeeivdllrs.ldleeaaerlvelalarggrDNiTvvvvrld

LRR_4 Leucine Rich repeats (2 copies) 302-338 2.1e-07 20.4 Pfam-A 1-37 (44) alignment
Range on Protein: 302-338
Range on HMM: 1-37/44.0
PELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLL
. || | ||.| ...||.|.| | .|..| . || . 
tnLevLdLsnNnIkdlppelanLpnLktLnLsnNpis

LRR_4 Leucine Rich repeats (2 copies) 279-317 3e-07 19.9 Pfam-A 2-39 (44) alignment
Range on Protein: 279-317
Range on HMM: 2-39/44.0
KLRVLHLAYNRIGVLPAaCVRNWPELEILVLSGNMLQQL
.|.|| |..|.|  ||.  . |.| |. | ||.| .. |
nLevLdLsnNnIkdlpp.elanLpnLktLnLsnNpisdl

PP2C Protein phosphatase 2C 581-645 2.2e-06 20.4 Pfam-A 184-252 (255) alignment
Range on Protein: 581-645
Range on HMM: 184-252/255.0
QIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENS----LLAAKRLVDIAQSFAAA
. .  ..|.| .  |...||.|....  || |.. . |.  .|.|...      ||..||| |.. ...
eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargse

PP2C Protein phosphatase 2C 581-645 2.2e-06 20.4 In-house 184-252 (255) alignment
Range on Protein: 581-645
Range on HMM: 184-252/255.0
QIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENS----LLAAKRLVDIAQSFAAA
. .  ..|.| .  |...||.|....  || |.. . |.  .|.|...      ||..||| |.. ...
eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargse

LRR_8 Leucine rich repeat 183-225 2.7e-06 16.7 Pfam-A 2-45 (61) alignment
Range on Protein: 183-225
Range on HMM: 2-45/61.0
ELVSLDLAYNDLKQLDQ-FPEGFSSIRSLQLQSNELPSLPDNFF
.| .|||  |.|| ... . .| |. ..| |..|.| |.... |
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeaf

LRR_4 Leucine Rich repeats (2 copies) 349-381 3.1e-06 16.6 Pfam-A 3-34 (44) alignment
Range on Protein: 349-381
Range on HMM: 3-34/44.0
LKVLDLSHNHLDRVNL-LAlvPSRNLKYLDLSGN
|.|||||.| .  ..  ||    .|||.|.||.|
LevLdLsnNnIkdlppela..nLpnLktLnLsnN

LRR_4 Leucine Rich repeats (2 copies) 231-276 6.9e-06 15.5 Pfam-A 2-44 (44) alignment
Range on Protein: 231-276
Range on HMM: 2-44/44.0
RLETLNVSCNKLSTLPRyEQNNHAALVNLSLAGNHLNDsiFEPLHN
 ||.|. | |... ||  |  |   | .|.|..|.. |  ...| |
nLevLdLsnNnIkdlpp.elanLpnLktLnLsnNpisd..lsaLan

LRR_4 Leucine Rich repeats (2 copies) 182-221 8.8e-06 15.2 Pfam-A 1-40 (44) alignment
Range on Protein: 182-221
Range on HMM: 1-40/44.0
TELVSLDLAYNDLKQLDQ-FpEGFSSIRSLQLQSNELPSLP
| | .|||..| .|.|.  .  .... ..| |..| . .|.
tnLevLdLsnNnIkdlppel.anLpnLktLnLsnNpisdls