Gene alph in Drosophila melanogaster

Synonym: CG1906, Dmel\CG1906, PP2Cb, SK3-1, pp2c99B, Dmel_CG1906, alph

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP127_AA protein Get Run
DmelP127_AA_3-286 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1A_pd Subfamily PPM1A 8-285 3.6e-119 390.3 In-house 3-281 (282) alignment 
Range on Protein: 8-285
Range on HMM: 3-281/282.0
PktakhNDEGEGNKLLFGVSSMQGWRSEMEDAYYARAGLGdALPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFI--------GGDHVKGIRTGFL
|     ....|||.| .|||||||||.|||||. . | || ||.||||||||||||| .|.....|||||.|...||.           .. ...|.|||
p.....ksqaegnglrygvssmqgwrvemEDahtvvaslg.alkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfL

RIDEVMRELPEFTRESEKCgGTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVMIKRVNGTLAVSRALGDYDFKNV
..|| .||| . .....|. |.|||...|  ....|||.|||||||||.|  .|.|.||||. |.||.|| .|||||...||||.||||||||||..|. 
aldeairelstdlktadks.GsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykee

KEKGQCEQLVSPEPEIFCQSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLVSIANQVVDTCLHKGSRDNMSIIIIAFP
.||...|||||.|||.....|...|.||||||||||||.|.|.|......|..|...| ..|...||..|.||||||.|.....|.
eekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa
0034914 PP2C-like 4-286 5.8e-86 280.7 In-house 3-292 (295) alignment 
Range on Protein: 4-286
Range on HMM: 3-292/295.0
FLDKPKTAKHNDEGEGNKLLFGVSSMQGWRSEMEDAYYARAGLGDALPDWSFFAVFDGHAGCKVSEHCAKHLLESIIS-------TEEFIGGDHVKGIRT
.|..|.. ...   . ..| .||.|.||.|...|||...  .|   |.|...|.||||| |....|.....|.| ...       . ..   | .. .|.
llslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrk

GFLRIDEVMRELPEFtRESEKCGGTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVMIKRVNGTLAVSRALGDYDF
.||..|| ..|| .  | .  ..|||||.|..  ...|.||.|||||||.|.|..|. | ||||  ..|.|||..||| |.  ||||.|||.|||||.|.
aflaadeellelall.rpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdl

KNVKEKGQCEQLVSPEPEIFCQSRQ-DSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLVSIANQVVDTCLHKGSRDNMSIIIIAFPG
|...   ..|.|||.||........ ..|.||.||.||.|||.|||.......|... . .|  .|...|| .|..|||||...... ..|
klllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlng
subfamily_PPM1G2_pd Subfamily PPM1G2 5-284 1.2e-81 266.8 In-house 2-286 (287) alignment 
Range on Protein: 5-284
Range on HMM: 2-286/287.0
LDKPKTAKHNDEGEGNKLLFGVSSMQGWRSEMEDAYYARAGLGD--ALPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGGDHVKGIRTGFLRID
|..| .||... .. ..  .| |.|||.| .||||.  .  | .    .. ..||||||| | ||.....|.| . | . ..|  |   . .. .||..|
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletD

EVMRELPEFTResEKCgGTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVMIKRVNGTLAVSRALGDYDFKNVKEK
| ...  ..    |.. |.||| . .  ...|.||.|||||||. .|     . ||||   .||.|| .||| | ..||||.||.||||||. ||. ..|
eellkdeklkd..esa.GstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkk

GQCEQLVSPEPEIFCQSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLVSIANQVVDTCLHKGSR------DNMSIIIIAF
.  ||.|  .|.. .......||||||||||||||..|..|. ....|..   .| .|.....|.|| . |.      |||...|...
kpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl
PP2C Protein phosphatase 2C 24-277 1.2e-80 263.8 Pfam-A 3-255 (255) alignment 
Range on Protein: 24-277
Range on HMM: 3-255/255.0
FGVSSMQGWRSEMEDAYYARAGLG--DALPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGG-DHVKGIRTGFLR-IDEVMRElpEFTRESEKCG
.|.|..||.|..||||  | . |.  ..  ...||||||||.| .... ...|| |.. . ..| .. .  |..| .||. .||...   . .....   
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks..skantepsks

GTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPV-FATQDHKPILPEEKERIYNAGGSVM-IKRVNGTLAVSRALGDYDFKNVKekgqcEQLVSPEPEIFC
|.|||.|..  ...|.||.|||||||||.. .. . |.||||  ..|.||| .|||||. ..||||.|||||||||...|. .     |||||.||..  
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvts

QSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLVSIANQVVDTCLHKGSRDNM
 .....||||.||.||.|||.|.........|..  ....  .|...|| .. .||.||.
vklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 24-277 1.2e-80 263.8 In-house 3-255 (255) alignment 
Range on Protein: 24-277
Range on HMM: 3-255/255.0
FGVSSMQGWRSEMEDAYYARAGLG--DALPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGG-DHVKGIRTGFLR-IDEVMRElpEFTRESEKCG
.|.|..||.|..||||  | . |.  ..  ...||||||||.| .... ...|| |.. . ..| .. .  |..| .||. .||...   . .....   
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks..skantepsks

GTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPV-FATQDHKPILPEEKERIYNAGGSVM-IKRVNGTLAVSRALGDYDFKNVKekgqcEQLVSPEPEIFC
|.|||.|..  ...|.||.|||||||||.. .. . |.||||  ..|.||| .|||||. ..||||.|||||||||...|. .     |||||.||..  
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvts

QSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLVSIANQVVDTCLHKGSRDNM
 .....||||.||.||.|||.|.........|..  ....  .|...|| .. .||.||.
vklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PPM_PTC7 24-277 4.3e-79 258.6 In-house 3-259 (259) alignment 
Range on Protein: 24-277
Range on HMM: 3-259/259.0
FGVSSMQGWRSEMEDAYYARAGLG--DALPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGG-DHVKGIRTGFLR--IDEVMRElpEFTRESEKC
.|.|..||.|..||||  | |.|.  .   ...||||||||.| .... ...|| |.. . ..|  . .  |..|..||.  .||...   . ... .. 
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelks..seantepst

GGTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPV-FATQDHKPILPEEKERIYNAGGSVM---IKRVNGTLAVSRALGDYDFKNVKEkgqCEQLVSPEPE
.|.|||.|..  ...|.||.|||||||||.| .| . |.|||| ...|.||| .|||||.     ||||.||||||.||...|. .     |||||.||.
sGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsaePd

IFCQSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTsNLVSIANQVVDTCLHKGSRDNM
|    ....||||.||.||.|||.|.........|..  .  .  .|...||... .||.||.
isstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni
PP2Cc_SM00332 14-282 1.5e-78 257.0 In-house 2-274 (274) alignment 
Range on Protein: 14-282
Range on HMM: 2-274/274.0
NDEGEGNKLLFGVSSMQGWRSEMEDAYYARAGLGdALPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGG----DHVKGIRTGFLRIDEVMRELP
. .|....| .|.|||||||..||||.  .  |     ||.||.|||||.| .|.. ..|.| | .... ..  .    |  . ....||..|| ..|  
sesgsnlglsygkssmqgwrksmeDahvvvvdlv.eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileee

EFTRESEKCGGTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVMIKRVNGTLAVSRALGDYDFKNVKekGQCEQLV
.  .. .   |.|||.|..   ..|.||.|||||||||.|  |  ..||||  ..|..|| .|||.|. .||||.||||||.||...|. |  .. |. .
qskelenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klkepyi

SPEPEIFCQSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRM--RVTSNLVSIANQVVDTCLHK-GSRDNMSIIII
..||.. . .  ..||||.||.||.|||.||..|........  ..| .   .|..... .. . ||.||......
taepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
0049733 PP2C-like 24-284 7e-61 198.4 In-house 5-233 (235) alignment 
Range on Protein: 24-284
Range on HMM: 5-233/235.0
FGVSSMQGW-RSEMEDAYYAraglgdalpDWSFFAVFDGHAGCKVSEHCAKHLLESIIST-EEFIGGDHVKGIRTGFLRIDEVMRELPEFTReSEKCGGT
.|..|..|. |...|||...         ....|||.||| |. ..|.....|.| ...  .|.   | .. .|  ||...|...|| .  . .   .||
vgaasdigrvrkvneDavlv.........glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalasp.elagmgt

TAVCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVmikRVNGTLAVSRALGDYDFKnvkekgqceqlvspePEIFCQSRQ
|||.|..   ..|.||.|||||.|.|.|  |. |.||.|  ..|..||..||| |   ||.| ||..|||||...|               |....   .
TavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...............pdvtvlele

DSDeFLVLACDGIWDVMSNEDVCSFIHSrmrvtSNLVSIANQVVDTCLHKGSRDNMSIIIIAF
. | ||.||.||.|||.|.|.......|      .|  .|...|...|..|.|||...... .
pgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrl
subfamily_PPM1E_pd Subfamily PPM1E 26-284 6.1e-56 182.5 In-house 8-262 (265) alignment 
Range on Protein: 26-284
Range on HMM: 8-262/265.0
VSSMQGWRSEMEDAYYARAGLGDALP-----DWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGgDHVKGIRTGFLRIDEVMRElpEFTRESEKCgG
. .... |  ||| . |   |.  .      . .||||||||.| . ... |.|| | ... |...  | .. .. .| ..|| . .    .||. |. |
iaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklke.dpaealkeafkltDerflq..kaereklks.G

TTAVCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVMI---KRVNGTLAVSRALGDYDFKnvkekgqceQLVSPEPEIFC
.|||....   |.|.|  |||.|.|.|.|  |  .. |||  ..||.|| .||| |.     ||||.|.||||.||.. |         . || |...  
stavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk.........pyvsgeadvae

QSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTS-NLVSIANQVVDTCLHKGSRDNMSIIIIAF
 . ..|.|.|.|||||.|||. .|.|.. ... .. .. .| ..|...|..  ..||.||...... .
veldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl
subfamily_PPM1G_pd Subfamily PPM1G 119-284 4e-51 167.5 In-house 296-470 (473) alignment 
Range on Protein: 119-284
Range on HMM: 296-470/473.0
GGTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVM-IKRVNGTLAVSRALGDYDFKNVKEKGQCEQLVSPEPEIFC
 ||||| | .   ....|| ||||.||.|.|. .    ||||. ..|.||| .||| |    |||| | .||||||. .|. .| .. ||..|  |.|  
sGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDikv

QSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTS--NLVSIANQVVDTCLHKGS------RDNMSIIIIAF
.  .. ||||||||||||.||. ..|  |...... ..   | .| ....|.|| .         |||..||. .
ltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 18-285 1.2e-50 165.2 In-house 2-254 (255) alignment 
Range on Protein: 18-285
Range on HMM: 2-254/255.0
EGNKLLFGVSSMQGWRSEMEDAYYARAGLGDAlPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGGDHVKGIRTGFLRIDEVMRELPeftreseK
.....  | | | | |. ||| . .     |  .|  ..|.||||.| . .......|   . .  .    . || ..  .  |.  . | |       |
dssrfkvgfsdmiGrrptmedelviyGsfrdk.sdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqiserp.......k

CGGTTAVCAFVGLTQVYIANCGDSRAVLC-RQGVPVFATQDHKPILPEEKERIYNAGGSVMIK----RVNGTLAVSRALGDYdFknvkekgqCEQLVSPE
  ||||. ...   .||||| ||||.||| ..|. .  . ||||  ..|..|| ..|| |. .    ||||||||||||||  |         |  | |.
fiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.f........lePfvvpd

PEIF-CQSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSrmrvTSNLVSIANQVVDTCLHKGSRDNMSIIIIAFP
|..      . .|.||.||||||||..|.|. .. . .     |.    |... |   ..|| ||.|.|.| ..
PdlsqsleiskkdkflilacdGiwdlisdeeaveivag....isdpekaaeklrdlayssGstdnisvivikls
subfamily_PPM1L_pd Subfamily PPM1L 26-284 6.7e-43 139.9 In-house 9-266 (269) alignment 
Range on Protein: 26-284
Range on HMM: 9-266/269.0
VSSMQGWRSEMEDAYYARAGLGDALpDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGGDH--VKGIRTGFLRIDEVM---RELPEFTRESEKCGG
| |..| | .||| .    .. .   . ||||||||| |   .|.. . | ..| .    .  |.   . |  . |  ||..   ..| | .. .|.  |
vysvlGrrprmedrfeieediknkt.gesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraediaG

TTAVCAFVGLTQVYIANCGDSRAVLC-RQGVPVFATQDHKPILPEEKERIYNAGGSVMIK---RVNGTLAVSRALGDYDFKNvkekgqcEQLVSPEPEIF
|||. |.|  ... .|| |||| ||. ..|  .  . ||||  ..|. || .||| . ..   ||.| ||.||||||| .|.       ..|| ..|.|.
ttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkd.......knlviadpdil

CQSRQD-SDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSnlvSIANQVVDTCLHKGSRDNMSIIIIAF
.   .|   |||.||.||.|| .|||. . ||. |.         |  .|  . ..|| ||...... .
tfdlddhkpeflilasdGlwdtfsneeavrfikerlkepd...fGakslvlesfkrGsvdnitvlvvkl
subfamily_ILKAP_pd Subfamily ILKAP 29-260 8.1e-41 133.1 In-house 12-252 (293) alignment 
Range on Protein: 29-260
Range on HMM: 12-252/293.0
MQGWRSEMEDAYYARAGLG------D-ALPDWSFFAVFDGHAGCKVSEHCAKHLLESIIS---TEEFIGGD-HV-KGIRTGFLRIDEVMRELPEFTRESE
 .| | ||.||   .  |       .  .   |..|||||||| . ||..|..| ..|..    ...   . .. | .   | . || . .| . .. . 
rkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskakPvW

KCGgTTAVCAFVGLTQVYIANCGDSRAVLCRQG------VPVFATQDHKPILPEEKERIYNAGGSVMIKRVNGTLAVSRALGDYDFKNVkekGqceqlVS
| | .||.. .|    .|.|| |||.|||.|.       . |  |.||.|.  ||..||  |||.|   ||.| | |||..||  ||..   |     |.
kdG.statvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrl...G.....vi

PEPEIFCQSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLVSI
  |..     .. | |.||||||.|.|.|...| .|| . .    .  .|
stPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrki
PPM_PTC7_SpoIIE 24-260 9.9e-41 133.0 In-house 3-213 (230) alignment 
Range on Protein: 24-260
Range on HMM: 3-213/230.0
FGVSSMQGWRSEMEDAYYARAGLG--DALPDWSFFAVFDGHAGCKvsEHCAKHLLESIISTEeFIGGD-HVKGIRTGFLRIDEVMRELpeftresEKCGG
.|.|..||.|..||||  ..|...  .    . .....||| |      ....| . . .   | |..   . .| ..|...  ...        .. .|
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede.......psssg

TTAVCAFVGLTQ--VYIANCGDSRAVLCRQ-GVpvfatqdhkpilpeEKERIyNAGGSVM----IKRVNGTLAVSRALGDYDFKNvkekgqCEQLVSPEP
.|||.| .  ..  .|.||.|||...|.|. |               |.|||  ||| ..      ||.|.||||.| ||. ..        ...|..||
aTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDGvveaep

EiFCQSRQDS-DEFLVLACDGIWDVMSNEDVCSFIHSRMRVTsnlvsI
.   . . .. ||||.||.||.|||.|........ ...        .
d.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....a
subfamily_PPM1K_pd Subfamily PPM1K 25-284 1.2e-40 132.3 In-house 7-258 (263) alignment 
Range on Protein: 25-284
Range on HMM: 7-258/263.0
GVSSMQGWRSEMEDayyaRAGLGDALPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEeFIGGDHVKGIRTGFLRIDEVMRELPEFT--RESEKCGGTT
|. |..| |.| ||    |  | .  |.  ..||||||||    ... ..| . .         |  . ..  |. .|. ..   ||.   ....  |||
GkdsliGkraened....riklkeldpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkrylefsvaeaellssGtt

A-VCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVMI-----KRVNGTLAVSRALGDYDFKNvkeKGqceQLVSPEPEIF
| |. .   |.. .|. |||||.|||.| .   |.||.| | |||||| .|||||        .||| ||..|.||| |.|.    |    .  ||   .
atvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkr...yG...viatPetksl

cQSRQDSDEFLVLACDGIWDVMSNEDVCSFIhsrmRVTSNLVSIANQVVDTCLHKGSRDNMSIIIIAF
 . . ..| ||||  ||| .|......| ..    |.  .    |. .... |  || || ..... .
.kvdhaadsflvlitdgisfvvnsqelcdlv....rlchdpeeaahalteqalqygsednatavvvpl
PP2C_C Protein serine/threonine phosphatase 2C, C-terminal domain 278-356 1.4e-30 94.9 Pfam-A 1-81 (81) alignment 
Range on Protein: 278-356
Range on HMM: 1-81/81.0
SIIIIAFPGAPKPTEEAIEAEHRLEKQIEKITRDEIES---SKITDYVDLLKCLQNRDdIEGLPPGGGLQSKYHVIERTFKQ
|||...||||||..|||...|..|.|..|..... ||.   ....|....||.|.. | |..|||||||.||..|||...|.
siilvcfpgAPkvseeAvkkeaeLdkalesrveeiieksseeevpdllsvlktlased.ipnLPPGGglasKrsvieavykk
subfamily_KAPP-like_pd Subfamily KAPP-like 31-283 6.3e-30 97.1 In-house 7-265 (266) alignment 
Range on Protein: 31-283
Range on HMM: 7-265/266.0
GWRSEMEDAYYARAGLGDALP-----DWSFFAVFDGHAGCK--V--SEHCAKHLLESIISTEEFIGGDHVKGIRTGFLR-IDEVMRELPEFtrESEKCGG
|   |||| . |   |..        . ..|||||||||    .  ..   | | . . ||..  ||| .   .  ..  ..||  .| .|  | | .  
gcstemedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdf..eyeGata

TTAVCAFVGlTQVYI--ANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVM--IKRVNGtLAVSRALGDYDFKNVKEKGQCEQLVSPEPEIF
| |.    |  | |.  || ||| | |.|    .. ..|||   |||| || . | ..     |.|| |||||||||.  |.       |  ||..  . 
tlalvwsdG.qqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrillt

CQsrqdsDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLVSIANQVVDTCLHK-GSRDNMSIIIIA
 .     |.||..| ||.|||.| .|    ..| .   .   ..|. ...| ..   ..||.|.|.. 
pf.....dkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvk
subfamily_PPM1D_pd Subfamily PPM1D 26-179 2.8e-27 88.6 In-house 6-174 (309) alignment 
Range on Protein: 26-179
Range on HMM: 6-174/309.0
VSSMQGWRSEMEDAYYARAGLGDAL--PDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGGDH---VKGIRTGFLRIDEVMREL----PEFTRESE
... || |  |||         . .   ...|.|||||| | . ...  .||.. |   ..|.  .    .. || .|| . | |..     |. ..   
seadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgll

KCGGTTAVCAFVGLTQVYIANCGDSRAVLCRQGV------PVFATQDHKPILPEEKERIYNAGGSVMIK
   |||| . ..  ...|.|. |||..||  .        .   |.||||  ||||||| ..||.|..|
staGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaak
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 31-283 7.3e-27 86.9 In-house 6-275 (276) alignment 
Range on Protein: 31-283
Range on HMM: 6-275/276.0
GWRSEMEDAYYARAGLGDALP-----DWSFFAVFDGHAGCKVS----EHCAKHLLESIIS-----TEEFIGGDHVKGIRTGFLRI-DEVMRELPEFtrES
|   |||| . |   |.|        . ..|||||||||  ..    .   | |.  . |     |..  ||| .   .  .| . .||  .| .|  | 
gcstemedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdf..ey

EKCGGTTAVCAFVG-----LTQVY--IANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVM--IKRVNGtLAVSRALGDYDFKNVKEKGQCE
| .  | |.    |       | |  .|| ||| | |.|    .. ..|||   ||||.|| . | ..     |.|| |||||||||.  |.       |
eGatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlise

QLVSPEPEIFCQsrqdsDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLVSIANQVVDTCLHK-GSRDNMSIIIIA
  ||..  .  .     |.||..| ||.|||.| .|    ..| .   .   ..|. ...| ..   ..||.|.|.. 
pyvsnrilltpf.....dkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvk
subfamily_PP2D1_pd Subfamily PP2D1 130-254 7e-26 84.0 In-house 187-309 (492) alignment 
Range on Protein: 130-254
Range on HMM: 187-309/492.0
LTQVYIANCGDSRAVLCRQGVPVFATQDHKPILPEEKERIYNAGGSVM----IKRVNGTLAVSRALGDYDFKNVKekgqceQLVSPEPEIFCQSRQDSDE
|. .|||| |. .|||||.|. .  |..| |  ..|..|. .||..|.      .||| | . | || |   ..|      . | |||.. .   .. . 
lgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLk......ksvipePkttsvkldeaaq

FLVLACDGIWDVMSNEDVCSFIHSRMRVT
|||||  |.|.|.|.|.| | ... ... 
flvlAsnGlWevlseeevlsLvkqtlaiy
subfamily_PPM1G_pd Subfamily PPM1G 4-106 1.4e-24 79.9 In-house 1-100 (473) alignment 
Range on Protein: 4-106
Range on HMM: 1-100/473.0
FLDKPKTAKHNDEGEGNKLLFGVSSMQGWRSEMEDAYYAragLGDALPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGGDHVKGIRTGFLRIDE
.|.|||. |.....  ..| .|.|.||||| ..|||  .   . |   |.|.|||.||| | .|....||.|.. .  .. .  ||  |...  || .||
ylskpkvekesedesneelsygasamqGwrvsqEDahnc...itdldedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDe

VMR
 ..
klk
subfamily_PDP_pd Subfamily PDP 116-271 7.5e-21 67.7 In-house 149-332 (398) alignment 
Range on Protein: 116-271
Range on HMM: 149-332/398.0
EKCGGTTAVCAFVGLTQVYIANCGDSRAVLCRQ---G--VPVFATQDHKPILPEEKERIYNAG---GS---VMIKRVNGTLAVSRALGDYDFKNVKEKGQ
  . |..|..|..  |....|| ||.||||..|   |    |  ..|.    .|| ||| ..     |   .. .|. |.|. .|| ||. .|  .|  .
valsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqk

--CEQ----LVSP-----------EPEIFCQSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLVSIANQVVDTCLHK
   |.     . |           |||.. .  . .| ||||| ||.||..|||.| | ..  .  . .  ... .  .. |..
kvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepvkveeakltlkq
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 55-194 1.1e-20 67.4 In-house 22-183 (292) alignment 
Range on Protein: 55-194
Range on HMM: 22-183/292.0
F-FAVFDGHA--GCKVSEHCAKHLLESIISTEEFIGgDHVkgiRTGFLRIDEVMRELPEFTRESEKCGGTTAVCAFVGLT-QVYIANCGDSRAVLCR---
|  ||.|||   | ||..  ...|   ....      .      .  ||| ..  .| . | .  . ..|..||| |    ....|| |||||.| |   
flaavldGhGvnGdkvaqlaedtlevelleltrqlq.els...ealllrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrclg

--QGVPVFATQDHKPILPEEKERIYNAGGSVMI-----------KRV------NGTLAVSRALGDY
  .  ..  ..||||  |.|..|| .||| |              ||      .| ||.||||||.
gsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdf
PPM_PTC7_motif 228-277 8.2e-17 54.5 In-house 1-51 (51) alignment 
Range on Protein: 228-277
Range on HMM: 1-51/51.0
VLACDGIWDVMSNEDVCSFIHSRMR-VTSNLVSIANQVVDTCLHKGSRDNM
.||.||.|||.|............      . ..|...||..| .|| ||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
PP2C_SIG_SM00331 55-283 2.3e-14 46.5 In-house 32-216 (217) alignment 
Range on Protein: 55-283
Range on HMM: 32-216/217.0
FFAVFDGH----AGCKVSEHCAKHLLESIISTeefiggdhvKGIRTGFLRIDEVMRELpeftrESEKCGGTTAVCAFV--GLTQVYIANCGDSRAVLCRQ
...|.||.    |.. .|.   . | |.. ..         . . . . |......|.     . || ...|...| .     ....||.|||| .| |.
llvvaDgmGkGlaAaaassqlrtalrellseg.........eelsqalkrlnraiyee.....keekgmfaTlllalydfssgklsyanaGdsrpyllrd

GVPVFATQDhkpilpeekeriynaggsvmikrvngtlavsralgdydfknvkekgQCEQLVSPEPEIF--CQSR-QDSDEFLVLACDGIWDVM-----SN
|  |. ..|                                              .  .... |||.    ...  . ...|.|. ||.....      .
gklveilkd..............................................vegaplGlepevsvdirelelekgdllllytDGltearsekgfae

EDVCSFIHSRMrvTSNLVSIAN----QVVDTCLHKGSRDNMSIIIIA
|... .. . .  .| .  .|.    ... .   .. .|....... 
erleeiledlv..dseaqelaqkiveellelakgsngeDdiTvvvvk
subfamily_PPM1H_pd Subfamily PPM1H 179-253 2.6e-14 45.8 In-house 275-353 (404) alignment 
Range on Protein: 179-253
Range on HMM: 275-353/404.0
KRVNGTLAVSRALGDYDFKNVKEKGQCEQLVSPEPEIFC----QSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRV
.|. .|..|.| |||.. | |... .   ..||.||.      |  ...|. |.|| ||.|||.|||.|   ... .  
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlsk
subfamily_TAB1_pd Subfamily TAB1 115-268 5.2e-14 44.8 In-house 125-299 (333) alignment 
Range on Protein: 115-268
Range on HMM: 125-299/333.0
SEKCGGTTAVCAFVGLTQVYIANCGDSRAVLCRQGVP---VFATQDHKPILPEEKERIYNAGGS-VMIKRV--NGTLAVSRALGDYDFKNVKEKGQ----
.|  |||||| | .   ..|.||.|||||.|... .    .   .||.   ..| .|. . |     |||.   |     |..|||  |.  .  .    
eeisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdilss

-CEQLVSPEPEIFCQ-SRQDSDEFLVLACDGIWDVMS--------NED-VCSFIHSRMRVTSNLVSIANQVVDTC
  .. |  ||.|      .|.  ||||  ||.   .         | . .   .  ..    .| ..|..|||  
akgePviaePdiqgaypiddityflvlmSdGvyktLeevtgpetsnvenillevitelekqatlqdvAqavvdkv
subfamily_PPM1D_pd Subfamily PPM1D 185-284 8.4e-14 44.4 In-house 201-307 (309) alignment 
Range on Protein: 185-284
Range on HMM: 201-307/309.0
LAVSRALGDYDFKNVKEKgqcEQLVSPEPEIFCQSRQDSDE-FLVLACDGIWDVMSNEDVCSFIHSRMRVTSN----LVSIANQVVDTCLHKGSR-----
|||.|.|||    | | .   | .|||||..  . .. ..| |..|| ||.|.|.. ||. |....   ...       |.|...|.. |.. ..     
LavaRslGDlWsynaksg...efvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklra

DNMSIIIIAF
||.|.|.. .
Dnvsvivvil
Subfamily Dicty-PPM1L-like 164-284 7.1e-13 41.0 In-house 181-303 (305) alignment 
Range on Protein: 164-284
Range on HMM: 181-303/305.0
EEKERIYNAGGSVMIK---RVNGTLAVSRALGDYDFKNVKEkgqceqlvsPEPEI-FCQSRQDSDEFLVLACDGIWDVMSNEDVCSFIHSRMRVTSNLV-
|.. ||  ......     .||. | .||  || . | .           |...       . .|.||||| ||.|.|.|..||  ...  .| .|    
eiririeslqaalynygellvnrllkksrskGdknlkelvi.........PnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkk

------SIANQVVDTCLHKGSRDNMSIIIIAF
       | . .|   ...||.||. ..|| .
iewdfneisrviveeavkrgsgDnitlviikl
subfamily_PHLPP_pd Subfamily PHLPP 132-284 5.4e-12 38.1 In-house 106-245 (246) alignment 
Range on Protein: 132-284
Range on HMM: 106-245/246.0
QVYIANCGDSRAVLCRQGVPVFATQDHKpILPEEKERIYNAGGSVMI-KRVNGTLAVSRALGDYDFKnvkekgqceQLVSPEPEIFCQSRQDSDEFLVLA
.. .|. |   |||.|.| ..  .. .. |  .| .|| .| . .    ..|| .. .| || .              | |.|..     .. ||.|.. 
sLevAsvGtlqavliRngkklrlsksyv.iekdelkrikeakaiitednkingviestrllGytflf.........PvvlPkphvrevlLteqdellivG

CDGIWDVMSNEDVCSFIHSrmrvTSNLVSIANQVVDTCLHKGSRDNMSIIIIAF
 . .|.|.| ... . ..       . . .| ..||     | .|..|.... .
nkalWevlsideaveavrk....eedplvaAkklvdlaqsygaadsvsvlvvrl
subfamily_PPM1H_pd Subfamily PPM1H 94-169 2.2e-10 32.9 In-house 140-210 (404) alignment 
Range on Protein: 94-169
Range on HMM: 140-210/404.0
IRTGFLRIDEVMRElpEfTRESEKCGGTTAVCAFVGLTQVYIANCGDSRAVLCRQGVPVFATQDHKPIlpEEKERI
. . ||..||....  |  .. .. || ||. | | | ..|.|| |||||.|.|..  .   .|. |    |..|.
lesaflemDeqiar..e.reayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPe..teRqRl
PPM_PTC7_SpoIIE_motif 225-283 2e-08 27.8 In-house 13-79 (81) alignment 
Range on Protein: 225-283
Range on HMM: 13-79/81.0
EFLVLACDGIW-------DVMSNEDVCSFIHSRmRVTSnLVSIANQVVDTCLHKG---SRDNMSIIIIA
. |.|..||..       .....|......... .. | | ..| ..||..|  |   ..|....... 
dvllLyTDGltEardsdgelfgkeellrladra.egks.lqeladklvdevlengsgereDDitllvlr
subfamily_PP2D1_pd Subfamily PP2D1 31-78 1.8e-06 20.0 In-house 12-58 (492) alignment 
Range on Protein: 31-78
Range on HMM: 12-58/492.0
GWRSEMEDAYYARAGLGDAlPDWSFFAVFDGHAGCKVSEHCAKHLLES
 |.|.|||..      |.  .. .||...||. |    | .||.| | 
rWKskmeDkrtlqdyfgnd.vnscFfgiyDGynGataAeiaakelhev
PP2C_2 Protein phosphatase 2C 50-247 6.6e-06 18.6 Pfam-A 21-191 (212) alignment 
Range on Protein: 50-247
Range on HMM: 21-191/212.0
LPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGGDHVKG-IRTGFLRIDEVMREL------PEFTRESEKCGGTTAVCAFVGLTQVYIANCGDSR
  |....|| ||.  .| |.. |. . |..... | .  .  .  ... . .| . ....       | ..|. |  .|| ..|..  ........||..
asdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDga

AVLC-RQGVPVFATQDHKPILPEEKERIYNA--GGSVmikrvngtlavsralgdydfknvkekgqceqlvspepeIFCQSRQDSDEFLVLACDGIWDVMS
.|.  |.|    ......     |  ... .  ....                                       . . . .. . |.|  ||..| ..
ivvrdrdgevqllgepdsgeyanettfltsedaeeel......................................rirrlklepgdalllmTDGvsdslr

NED-VCSFI
.|. . ...
keepfrell
PP2C_2 Protein phosphatase 2C 50-247 6.6e-06 18.6 In-house 21-191 (212) alignment 
Range on Protein: 50-247
Range on HMM: 21-191/212.0
LPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIGGDHVKG-IRTGFLRIDEVMREL------PEFTRESEKCGGTTAVCAFVGLTQVYIANCGDSR
  |....|| ||.  .| |.. |. . |..... | .  .  .  ... . .| . ....       | ..|. |  .|| ..|..  ........||..
asdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDga

AVLC-RQGVPVFATQDHKPILPEEKERIYNA--GGSVmikrvngtlavsralgdydfknvkekgqceqlvspepeIFCQSRQDSDEFLVLACDGIWDVMS
.|.  |.|    ......     |  ... .  ....                                       . . . .. . |.|  ||..| ..
ivvrdrdgevqllgepdsgeyanettfltsedaeeel......................................rirrlklepgdalllmTDGvsdslr

NED-VCSFI
.|. . ...
keepfrell