Gene CG6036 in Drosophila melanogaster

Synonym: Dmel\CG6036, PP2Cb, Dmel_CG6036, CG6036

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP128_AA protein Get Run
DmelP128_AA_8-285 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1A_pd Subfamily PPM1A 17-284 1.5e-114 375.1 In-house 3-281 (282) alignment 
Range on Protein: 17-284
Range on HMM: 3-281/282.0
QAQEGHGNGLRYCVSSMQGWRLEMEDSHSAACRLKdPFATWSYFAVFDGHAGSQISLHCAEHLMSTILESESF--------SKHKYEAGIREGFLQLDED
 .....||||||.|||||||| ||||.|.....|.   ..||.||||||||||... ....||...|||.|..        .|.... ..|.|||.|||.
pksqaegnglrygvssmqgwrvemEDahtvvaslg.alkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldea

MRKLYHDQQG----GSTAICVFVSPDKIYLVNCGDSRAVISRNGAAVISTIDHKPFSPKEQERIQNAGGSVMIKRINGTLAVSRAFGDYDFKNDGSKSPV
.|.| .|...    ||||..|.||.......|.||||||..|||.|...| |||| .|||..||..|||||...|.||.||||||.|||..|.. .|.. 
irelstdlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkae

DQMVSPEPDIIVCNRSEHDEFIVVACDGIWDVMTSSEVCEFIRSRLLVTYDLPMIVNSVLDICLHKGSRDNMTLLLLLLP
.|.||.||.. ...|||.|.|.|.||||||||....||.|..|.|| |...| .......| .|.||||||...|..|..
eqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa
subfamily_PPM1G2_pd Subfamily PPM1G2 9-283 9.4e-84 273.7 In-house 2-286 (287) alignment 
Range on Protein: 9-283
Range on HMM: 2-286/287.0
LEKPETEKQAQEGHGNGLRYCVSSMQGWRLEMEDSHSAACRLK--DPFATWSYFAVFDGHAGSQISLHCAEHLMSTILESESFSKHKYEAGIREGFLQLD
|..| ..|. . .. .  .   |.|||.||.|||.|     |   .   . ..||||||| |.... .....|...| . .||.. . |  ....||..|
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletD

EDMRKL--YHDQQGGSTAICVFVSPDKIYLVNCGDSRAVISRNGAAVISTIDHKPFSPKEQERIQNAGGSVMIKRINGTLAVSRAFGDYDFKNDGSKSPV
|...|    .|.. ||||. | .. .|.|  |.||||||.| .| .   ..|||| . .|..||..||| | ..|.||.||.|||.||. ||.  .|.| 
eellkdeklkdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpe

DQMVSPEPDIIVCNRSEHDEFIVVACDGIWDVMTSSEVCEFIRSRLLVTYDLPMIVNSVLDICLHKGSR------DNMTLLLLLL
.|.|  .||..| ...|.|||.|.||||||||.|..||....|.||    .|  |....|| || . |.      ||||.... |
eqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl
0034914 PP2C-like 9-285 4.5e-81 264.7 In-house 4-292 (295) alignment 
Range on Protein: 9-285
Range on HMM: 4-292/295.0
LEKPETEKQAQEGHGNGLRYCVSSMQGWRLEMEDSHSAACRLKDPFATWSYFAVFDGHAGSQISLHCAEHLMSTILE-------SESFSKHKYEAGIREG
|..| .|.     . . ||..|.|.||.| ..||.... ..|   .  ...|.||||| |.... ...|.|....||       . ..| . .|  .|..
lslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrka

FLQLDEDMRKLY----HDQQGGSTAICVFVSPDKIYLVNCGDSRAVISRNGAAVISTIDHKPFSPKEQERIQNAGGSVMIKRINGTLAVSRAFGDYDFKN
||..||....|     ... .|.||..... ..|.|. |.||||||..||| .|  |.|||| .. |.|||..||| |.  |.||.|||.||.||.|.|.
flaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlkl

DGSKSPVDQMVSPEPDIIVCNRS-EHDEFIVVACDGIWDVMTSSEVCEFIRSRLLVTYDLPMIVNSVLDICLHKGSRDNMTLLLLLLPG
  |  .....||.|||..| ... |.|.|...|.||.|||....|.....||.|  ..|| .... ..|..|..|||||.| ... |.|
llslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlng
PP2C Protein phosphatase 2C 28-276 8.4e-78 254.5 Pfam-A 3-255 (255) alignment 
Range on Protein: 28-276
Range on HMM: 3-255/255.0
YCVSSMQGWRLEMEDSHSAACRLK--DPFATWSYFAVFDGHAGSQISLHCAEHLMSTILESESFSKH-KYEAGIREGFLQ-LDEDMRK----LyHDQQGG
. .|..||.| .|||.| |   |.  ..  ....|||||||.|....  ..|||   . |..||..  |.|...|..||. .|| ...      .... |
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskant.epsksG

STAICVFVSPDKIYLVNCGDSRAVISRNGAAV-ISTIDHKPFSPKEQERIQNAGGSVM-IKRINGTLAVSRAFGDYDFKNDGskspvDQMVSPEPDIIVC
|||........|.|. |.||||||..|.. |.   | |||| ...| |||..|||||. ..|.||.||||||.||...|..       |.||.|||. . 
stavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvtsv

NRSEHDEFIVVACDGIWDVMTSSEVCEFIRSRLLVTYDLPMIVNSVLDICLHKGSRDNM
...|.|||...|.||.|||... |.....||.|  .... .. . ..| .. .||.||.
klteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 28-276 8.4e-78 254.5 In-house 3-255 (255) alignment 
Range on Protein: 28-276
Range on HMM: 3-255/255.0
YCVSSMQGWRLEMEDSHSAACRLK--DPFATWSYFAVFDGHAGSQISLHCAEHLMSTILESESFSKH-KYEAGIREGFLQ-LDEDMRK----LyHDQQGG
. .|..||.| .|||.| |   |.  ..  ....|||||||.|....  ..|||   . |..||..  |.|...|..||. .|| ...      .... |
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskant.epsksG

STAICVFVSPDKIYLVNCGDSRAVISRNGAAV-ISTIDHKPFSPKEQERIQNAGGSVM-IKRINGTLAVSRAFGDYDFKNDGskspvDQMVSPEPDIIVC
|||........|.|. |.||||||..|.. |.   | |||| ...| |||..|||||. ..|.||.||||||.||...|..       |.||.|||. . 
stavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvtsv

NRSEHDEFIVVACDGIWDVMTSSEVCEFIRSRLLVTYDLPMIVNSVLDICLHKGSRDNM
...|.|||...|.||.|||... |.....||.|  .... .. . ..| .. .||.||.
klteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PPM_PTC7 28-276 1.1e-76 250.7 In-house 3-259 (259) alignment 
Range on Protein: 28-276
Range on HMM: 3-259/259.0
YCVSSMQGWRLEMEDSHSAACRLK--DPFATWSYFAVFDGHAGSQISLHCAEHLMSTILESESFSKH-KYEAGIREGFLQLDEDMRKLY-----HDQQGG
. .|..||.| .|||.| |.  |   ..   ...|||||||.|....  ..|||   . |..|| .  |.|...|..||.|| |...       .....|
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepstsG

STAICVFVSPDKIYLVNCGDSRAVISRNGAAV-ISTIDHKPFSPKEQERIQNAGGSVM---IKRINGTLAVSRAFGDYDFKNDGSkspVDQMVSPEPDII
|||........|.|  |.||||||..|.| ||   | |||| ...| |||..|||||.     |.||.|||||||||...|.. .     |.||.|||| 
stAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsaePdis

VCNRSEHDEFIVVACDGIWDVMTSSEVCEFIRSRLLVTyDLPMIVNSVLDICLHKGSRDNM
. ...|.|||...|.||.|||... |.....||.|  . |. .. . ..| .. .||.||.
stkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni
PP2Cc_SM00332 19-280 1.1e-75 247.6 In-house 3-273 (274) alignment 
Range on Protein: 19-280
Range on HMM: 3-273/274.0
QEGHGNGLRYCVSSMQGWRLEMEDSHSAACRLKdPFATWSYFAVFDGHAGSQISLHCAEHLMSTILESESFSKH----KYEAGIREGFLQLDEDMRKLYH
..| ..||.| .||||||| .||| |    .|. . . |..|.|||||.||...  ....|.. . |. .. |     . |. ....||..||.... ..
esgsnlglsygkssmqgwrksmeDahvvvvdlv.eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeq

D-----QQGGSTAICVFVSPDKIYLVNCGDSRAVISRNGAAVISTIDHKPFSPKEQERIQNAGGSVMIKRINGTLAVSRAFGDYDFKN-DgskSPVDQMV
      .  ||||...... ...|. |.||||||..||| ||  . ||||. ..| .||..|||.|. .|.||.|||||||||...|. .   .. ....
skelenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk...klkepyi

SPEPDIIVCNRSEHDEFIVVACDGIWDVMTSSEVCEFIRSRL--LVTYDlPMIVNSVLDICLH-K-GSRDNMTLLL
..|||. |..  ..|||...|.||.|||... ||....|..|   .| | |. .   || ..  . ||.||.| ..
taepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktnd.pqeaaelldeeairrggseDniTvvv
0049733 PP2C-like 26-283 2.1e-56 183.7 In-house 3-233 (235) alignment 
Range on Protein: 26-283
Range on HMM: 3-233/235.0
LRYCVSSMQGW-RLEMEDSHSAacrlkdpfaTWSYFAVFDGHAGSQISLHCAEHLMSTILES-ESFSKHKYEAGIREGFLQLDEDMRKLYHD----QQGG
|.....|..|. | ..||.. .          ...|||.||| |.. . ...|.|..|.||  .... ...|. .|. ||...| ...|...    . .|
lsvgaasdigrvrkvneDavlv.........glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmg

STAICVFVSPDKIYLVNCGDSRAVISRNGAAVISTIDHKPFSPKEQERIQNAGGSVmikRINGTLAVSRAFGDYDFKndgskspvdqmvspePDIIVCNR
.||..... ..|.|..|.|||||.. |.| .|  | ||.|. . |..||..||| |   |..| ||..||.||...|               ||. |.. 
tTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...............pdvtvlel

SEHDeFIVVACDGIWDVMTSSEVCEFIRSrllvtYDLPMIVNSVLDICLHKGSRDNMTLLLLLL
...| |...|.||.|||....|.....||     .|| .... ... .|..|.|||.|.... |
epgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrl
subfamily_PPM1E_pd Subfamily PPM1E 30-283 2.8e-52 170.5 In-house 8-262 (265) alignment 
Range on Protein: 30-283
Range on HMM: 8-262/265.0
VSSMQGWRLEMEDSHSAACRLKDPFA-----TWSYFAVFDGHAGSQISLHCAEHLMSTILESESFSKHKYEAgIREGFLQLDEDMRKL--YHDQQGGSTA
. .... |  ||| | |  .|   |      . ..|||||||.|.. . . |.|| ... . |.. .   || ..|.| ..|| . .       ..||||
iaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpaea.lkeafkltDerflqkaereklksGsta

ICVFVSPDKIYLVNCGDSRAVISRNGAAVISTIDHKPFSPKEQERIQNAGGSVMI---KRINGTLAVSRAFGDYDFKndgskspvdQMVSPEPDIIVCNR
..|... |..|.   |||.|.. |.| ||  .  |||  ..|..||..||| |.     |.||.|.|||| ||.. |         ..|| |.|.  .. 
vvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk.........pyvsgeadvaevel

SEHDEFIVVACDGIWDVMTSSEVCEFIRSRLLVTY-DLPMIVNSVLDICLHKGSRDNMTLLLLLL
 ...|....||||.|||.. .||.. ... |  .  || .. .....   ..||.||.| .. .|
dgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl
subfamily_PPM1G_pd Subfamily PPM1G 117-271 8.8e-52 169.6 In-house 295-452 (473) alignment 
Range on Protein: 117-271
Range on HMM: 295-452/473.0
QGGSTAICVFVSPDKIYLVNCGDSRAVISRNGAAVISTIDHKPFSPKEQERIQNAGGSVM-IKRINGTLAVSRAFGDYDFKNDGSKSPVDQMVSPEPDII
. |.||. . .  .|..  | ||||.|.|||| |.   .||||  ..|.|||..||| |    |.|| | .|||.||. .|.. .  . .||.|  ||| 
dsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDik

VCNRSEHDEFIVVACDGIWDVMTSSEVCEFIRSRLLVTY--DLPMIVNSVLDICLHKG
|    |.|||.|.||||||.||.| || .|.|..|  .    |  ||. .|| || . 
vltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapd
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 27-283 2.3e-45 147.9 In-house 7-253 (255) alignment 
Range on Protein: 27-283
Range on HMM: 7-253/255.0
RYCVSSMQGWRLEMEDSHSAACRLKDPFaTWSYFAVFDGHAGSQISLHCAEHLMSTILESESFSKHKYEAGIREGFLQLDEDMRKLYhdQQGGSTAICVF
.   | | | |  |||. ..    .|      |.|.||||.|.. . ...|.|   . |     . . .  ... . ...  . .    .  |.||. |.
kvgfsdmiGrrptmedelviyGsfrdks.dedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqiserp..kfiGttaasvl

VSPDKIYLVNCGDSRAVIS-RNGAAVISTIDHKPFSPKEQERIQNAGGSVMIK----RINGTLAVSRAFGDydfkndgskSPVDQMVSPEPDII-VCNRS
.  ||.|. | ||||.|.. ..| |.  ..||||  ..|..||...|| |. .    |.|||||||||.||         | ..  | |.||.    . |
iiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGd.........sflePfvvpdPdlsqsleis

EHDEFIVVACDGIWDVMTSSEVCEFIRSrllvTYDLPMIVNSVLDICLHKGSRDNMTLLLLLL
..|.|...|||||||...  | .| . .      |    .. . |   ..|| ||...... |
kkdkflilacdGiwdlisdeeaveivag....isdpekaaeklrdlayssGstdnisvivikl
subfamily_ILKAP_pd Subfamily ILKAP 32-250 1.3e-43 142.3 In-house 11-243 (293) alignment 
Range on Protein: 32-250
Range on HMM: 11-243/293.0
SMQGWRLEMEDSHSAACRL-------KDPFATWSYFAVFDGHAGSQISLHCAEHLMSTILE---SESFSK--HKYEAGIREGFLQLDEDMRKLYHDQQ--
  .| | ||.|.|     |       |.. .  ||.|||||||||. | ..||.|  .|||   ....|.  ..    . . | . ||.. || . ..  
erkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskakPv

--GGSTAICVFVSPDKIYLVNCGDSRAVISRNG------AAVISTIDHKPFSPKEQERIQNAGGSVMIKRINGTLAVSRAFGDYDFKNDGskspvdqmVS
   ||||..|.|  . .|  | |||.||. |.       |.|  | ||.| . .|..||| |||.|   |..| | |||. ||  ||. |        |.
WkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlG........vi

PEPDIIVCNRSEHDEFIVVACDGIWDVMTSSEVCEFIRSRL
  ||.  |. .| | |.|.||||.|.|.. .|| .|| . |
stPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvl
PPM_PTC7_SpoIIE 30-252 5.7e-43 140.4 In-house 5-211 (230) alignment 
Range on Protein: 30-252
Range on HMM: 5-211/230.0
VSSMQGWRLEMEDSHSAACRLK--DPFATWSYFAVFDGHAGSQislHCAEHLMSTILESESFSKHK-YEAGIREGFLQLDEDMRKLyhDQQGGSTAICVF
.|..||.| .|||.| ..  .   ..  .. .....||| |..   . |  |. |.|....|  .   |. .|...|.|. |...   ....|.||... 
asaaqgarksmedahispansekssggrlalvvgdvdGhGgra...alamgllrtalrelafaglekpeeilrrlnlalaadlede..psssgaTavval

VSPDK--IYLVNCGDSRAVISRNGAAvistidhkpfspkEQERIqNAGGSVM----IKRINGTLAVSRAFGDYDFKNdgskspVDQMVSPEPDIIVCNRS
. |..  .|..|.|||.....|...              | |||  ||| ..      |..|.||||.|.||. ..        |..|..||| .  .  
idpstgklyvanaGdsppllvrddgg.............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDGvveaepdtsdgelf

EHDEFIVVACDGIWDVMTSSEVCEFIRSRLLV
..|||...|.||.|||... |.....|..|. 
gkdeflilasdglwdvlspqelvdlvrdelek
subfamily_PPM1L_pd Subfamily PPM1L 29-281 8.4e-38 123.2 In-house 8-264 (269) alignment 
Range on Protein: 29-281
Range on HMM: 8-264/269.0
CVSSMQGWRLEMEDSHSAACRLKDPfATWSYFAVFDGHAGSQISLHCAEHLMSTILESE-SFSKH-------KYEAGIREGFLQLDEDMRKLY--HDQQG
.| |..| | .|||    .  .|.  .. |.||||||| |   . .. . |. .|..    . ..       ...  . .  | .||.. .      .  
avysvlGrrprmedrfeieediknk.tgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraedia

GSTAICVFVSPDKIYLVNCGDSRAVIS-RNGAAVISTIDHKPFSPKEQERIQNAGGSVMIK---RINGTLAVSRAFGDYDFKNDgskspvdQMVSPEPDI
|.||.  .|. ... . | |||| |.  ..| |.  . ||||  .||. ||..||| . ..   |..| ||.|||.||| .|.        ..| ..|||
GttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdk.......nlviadpdi

IVCNRSEHD-EFIVVACDGIWDVMTSSEVCEFIRSRLlvtYDLPMIVNSVLDICLHKGSRDNMTLLLL
.  .  .|. ||...|.||.|| ..  | ..||. ||    .  .   |.   . ..|| ||.|.|..
ltfdlddhkpeflilasdGlwdtfsneeavrfikerl...kepdfGakslvlesfkrGsvdnitvlvv
subfamily_PPM1D_pd Subfamily PPM1D 27-251 2.4e-35 115.1 In-house 3-266 (309) alignment 
Range on Protein: 27-251
Range on HMM: 3-266/309.0
RYCVSSMQGWRLEMEDSHSAACRLKDPF--ATWSYFAVFDGHAGSQISLHCAEHLMSTILESESFSKHK---YEAGIREGFLQLDEDMRKLYHD------
. .... || |  |||  . ..  ..      ....|||||| | . . .  |||.|.| . . |  ..     . |||.||.. | |.| ...      
svtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktks

---QQGGSTAICVFVSPDKIYLVNCGDSRAVISRNGA------AVISTIDHKPFSPKEQERIQNAGGSVMIK---------R----INGT--------LA
      |.|| .|..  .|.|. . |||..|.. .        |   | |||| ||.|.|||...||.|..|         |     ||         ||
gllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLa

VSRAFGDYDFKNDGSKspvDQMVSPEPDIIVCNRSEHDE-FIVVACDGIWDVMTSSEVCEFIRSRLL
|.|. ||    |  |.     .||||||. | ..  ..| ||..| ||.|.|.|.... .....   
vaRslGDlWsynaksg...efvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeee
subfamily_PPM1K_pd Subfamily PPM1K 31-280 2.7e-34 111.5 In-house 9-255 (263) alignment 
Range on Protein: 31-280
Range on HMM: 9-255/263.0
SSMQGWRLEMEDSHSAaCRLKDPFatwSYFAVFDGHAGSQISLHCAEHLMStILESESFSKHKYEAGIREGFLQLDEDMR-KLYHD------QQGGSTAI
 |..| | | ||  .   .|.. .    |.|||||||||    .. ..|   ||.      .. |  ... |..||....  |..       .. |.|| 
dsliGkraenedrikl.keldpel...lyvavfdGhaGsaaadfvhdklek.ilkrllekekdleivlknafeeldkklkrylefsvaeaellssGttat

CVFV-SPDKIYLVNCGDSRAVISRNGAAVISTIDHKPFSPKEQERIQNAGGSVMI-----KRINGTLAVSRAFGDYDFKNDGSkspvdqMVSPEPDIIVC
 ...    .. | . |||||.. ||| |   |.||.|   .|.|||..|||||        ..|| ||..|..|| |.|. |       .  ||   .  
vsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGv......iatPetkslkv

NRsEHDEFIVVACDGIWDVMTSSEVCEFIRsrllVTYDLPMIVNSVLDICLHKGSRDNMTLLL
.  ..| |.|.  ||| .|..| |.|...|    .  |     ... .  |  || || | ..
dh.aadsflvlitdgisfvvnsqelcdlvr....lchdpeeaahalteqalqygsednatavv
PP2C_C Protein serine/threonine phosphatase 2C, C-terminal domain 277-356 1.6e-30 94.6 Pfam-A 1-81 (81) alignment 
Range on Protein: 277-356
Range on HMM: 1-81/81.0
TLLLLLLPGAPKVDMDAVKAERSLDQTIVQITKEVIEKHEIHDFETLIRLMKRMAIN-IPNLPPGGGLYAKYYIIEQAFHE
...|...||||||...|||.|..||... ....|.|||.. .....|....|..| . ||||||||||..|...||.....
siilvcfpgAPkvseeAvkkeaeLdkalesrveeiieksseeevpdllsvlktlasedipnLPPGGglasKrsvieavykk
subfamily_PPM1G_pd Subfamily PPM1G 8-110 1.5e-26 86.4 In-house 1-100 (473) alignment 
Range on Protein: 8-110
Range on HMM: 1-100/473.0
FLEKPETEKQAQEGHGNGLRYCVSSMQGWRLEMEDSHSAACRLKDpfaTWSYFAVFDGHAGSQISLHCAEHLMSTILESESFSKHKYEAGIREGFLQLDE
.|.||..||. ...  ..|.|..|.||||| ..||.| .   |..   ..| |||.||| |.... ..|..|   . ..... . . |....| ||.|||
ylskpkvekesedesneelsygasamqGwrvsqEDahncitdlde...dtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDe

DMR
 ..
klk
subfamily_KAPP-like_pd Subfamily KAPP-like 56-280 2.2e-23 75.6 In-house 33-263 (266) alignment 
Range on Protein: 56-280
Range on HMM: 33-263/266.0
TWSYFAVFDGHAGSQISlHCAEHLMSTILESESFS---------KHKYEAGIREGFLQLDEDMRKlyHDQQGGSTAICVFV-SPDKIYLV--NCGDSRAV
  . |||||||||   .  .|..|.  .||    |         ...    ... | ..|. ...  .. .| ......   . .. ||   | ||| | 
nialfavfdGhaGkGaa.daakklfpkelekllkstkqddGGdniydqskllenafkevdaklkd..feyeGatatlalvwsdGqqrylqvanvGdssaf

ISRNGAAVISTIDHKPFSPKEQERIQNAGGSVM--IKRINGtLAVSRAFGDYDFKNDGSKSPVDQMVSPEPDIivcnrSEHDEFIVVACDGIWDVMTSSE
.||   ..  . |||   |.|. ||.. | ..     |||| ||||||.||.  |.       .  ||..  .     . .|.|..|| ||.|||..  .
lsrGneslelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrill.....tpfdkflivasdGlwdvisGkd

VCEFIRSRLLVTYDLPMIVNSVLDICLHK-GSRDNMTLLL
  | ..|          . .|.|.. ..   ..||.....
aiekvkslydqqatedkmasslletaiqsikakdnvsviv
subfamily_PP2D1_pd Subfamily PP2D1 129-249 2.5e-20 65.7 In-house 187-305 (492) alignment 
Range on Protein: 129-249
Range on HMM: 187-305/492.0
PDKIYLVNCGDSRAVISRNGAAVISTIDHKPFSPKEQERIQNAGGSVM----IKRINGTLAVSRAFGDYdfkndGsKSPVDQMVSPEPDIIVCNRSEHDE
.  .|. | |. .||. |.| |.| | .| |  .|| .|...||..|.      ..|| | . |  | |     |    . . | ||| ..  .  |.. 
lgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGny.....G.dpkLkksvipePkttsvkldeaaq

FIVVACDGIWDVMTSSEVCEFIRSR
|.|.|  |.|.|..  || . ... 
flvlAsnGlWevlseeevlsLvkqt
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 56-280 2.6e-20 65.5 In-house 32-273 (276) alignment 
Range on Protein: 56-280
Range on HMM: 32-273/276.0
TWSYFAVFDGHAGSQISLHcAEHLM----STILESESFSKHKYEAG----------IREGFLQLDEDMRKlyHDQQGGSTAICVFVSPD-------K--I
  . |||||||||   .   |..|.      .|.| ..|  | . |          . . | ..|. ...  .. .| ......  |         .  .
nialfavfdGhaGkGaada.akklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkd..feyeGatatlalvwsdGeeqqqqqqryl

YLVNCGDSRAVISRNGAAVISTIDHKPFSPKEQERIQNAGGSVM--IKRINGtLAVSRAFGDYDFKNDGSKSPVDQMVSPEPDIivcnrSEHDEFIVVAC
   | ||| | .||   ..  . |||   |.|..||.. | ..     |||| ||||||.||.  |.       .  ||..  .     . .|.|..|| 
qvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrill.....tpfdkflivas

DGIWDVMTSSEVCEFIRSRLLVTYDLPMIVNSVLDICLHK-GSRDNMTLLL
||.|||..  .  | ..|          . .|.|.. ..   ..||.....
dGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsviv
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 60-192 9.5e-20 64.3 In-house 24-182 (292) alignment 
Range on Protein: 60-192
Range on HMM: 24-182/292.0
FAVFDGHA--GSQISLHCAEHLMSTILESESFSKHKYEAGIrEGFLQLDEDMRKLYHD--QQGGSTAICVFVSPD-KIYLVNCGDSRAVISR-----NGA
 ||.|||   | ...   ...|   .||.    .   || .  . |..   ..||. |  ........|  |  | ...| | |||||.. |     .  
aavldGhGvnGdkvaqlaedtlevelleltrqlqelseall.lrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrclggsdye

AVISTIDHKPFSPKEQERIQNAGGSVMIKRI-----------------NGTLAVSRAFGD
 .  . ||||  | |..||..||| |   |.                 .| ||.||| ||
liPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGd
subfamily_PDP_pd Subfamily PDP 108-248 2.3e-18 59.5 In-house 129-310 (398) alignment 
Range on Protein: 108-248
Range on HMM: 129-310/398.0
D-------------MRKLYHDQQGGSTAICVFVSPDKIYLVNCGDSRAVISRN---GA--AVISTIDHKPFSPKEQERIQNAG---GS---VMIKRINGT
|             .|.  .    |..|............ | ||.|||. ..   |.  ||  ..|.   ...| |||...     |   .. .|. |.
distealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLge

LAVSRAFGDYDFKNDG--SKSPVDQ----MVSP-----------EPDIIVCNRSEHDEFIVVACDGIWDVMTSSEVCEFIRS
|. .|||||. .| .   .|... .    .. |           ||...  . .|.| |.|.| ||.||.....|| . .  
LqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVge
subfamily_PPM1H_pd Subfamily PPM1H 178-250 3.4e-13 42.1 In-house 275-351 (404) alignment 
Range on Protein: 178-250
Range on HMM: 275-351/404.0
KRINGTLAVSRAFGDYDFKNDGSKSPVDQMVSPEPDIIVCNR----SEHDEFIVVACDGIWDVMTSSEVCEFIRSRL
.|. .|..|.| .||.. |   ..  .  ..||.|.. | .     |..|. ...| ||.|||.. .|| | .|. |
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevl
PPM_PTC7_motif 227-276 3.9e-12 39.5 In-house 1-51 (51) alignment 
Range on Protein: 227-276
Range on HMM: 1-51/51.0
VVACDGIWDVMTSSEVCEFIRSRLLVTY-DLPMIVNSVLDICLHKGSRDNM
. |.||.|||... |.....|..|  .. .. .. . . | .| .|| ||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
subfamily_PPM1H_pd Subfamily PPM1H 99-170 1.7e-11 36.5 In-house 141-212 (404) alignment 
Range on Protein: 99-170
Range on HMM: 141-212/404.0
REGFLQLDEDMRK--LYHDQQGGSTAICVFVSPDKIYLVNCGDSRAVISRNGAAVISTIDHKPFSpkEQERIQN
 . ||..|| ...    . ..|| ||. . |  .|.|. | |||||...|... .    |. | .  |..|.|.
esaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPet..eRqRlqe
subfamily_PHLPP_pd Subfamily PHLPP 58-248 2.8e-11 35.8 In-house 28-214 (246) alignment 
Range on Protein: 58-248
Range on HMM: 28-214/246.0
SYFAVFDGHAGSQISlHCAEHLMSTILESESFSKHKYEAGIREGFLQLDEDMRKlyHDQQGGSTAICVFVSPDK--------IYLVNCGDSRAVISRNGA
. . .|||.. ...| .   .||. .|. |   ... |  ..  .|.   .. .    .. ||.|. . . .||        . . . |   ||. ||| 
alyGlfdGdrneels.sllqrlmkdvlkeevqkdkneeeymkntllvaqrklGe..aGeklgsaallilirhdkvdPaksfsLevAsvGtlqavliRngk

AVISTiDHKPFSPKEQERIQNAGGSVMI-KRINGTLAVSRAFGDYdfkndgSKSPvdqMVSPEPDIIVCNRSEHDEFIVVACDGIWDVMTSSEVCEFIRS
 .. .  .  ..  | .||..| . .    .||| .. .| .| .      .  |   .| |.| .     .| ||...|  . .|.|.   |. | .| 
klrls.ksyviekdelkrikeakaiitednkingviestrllGyt......flfP...vvlPkphvrevlLteqdellivGnkalWevlsideaveavrk
PP2C_SIG_SM00331 62-281 6e-11 35.3 In-house 35-215 (217) alignment 
Range on Protein: 62-281
Range on HMM: 35-215/217.0
VFDGHA---GSQISLHCAEHLMSTILESEsfskhkyeAGIREGFLQLDEDMRKLYHDQQGGSTAICVFV--SPDKIYLVNCGDSRAVISRNGAAVISTID
|.||.     ..     . ... ..|...          . . . .|.. .... ...... |...  .  | .|....|.|||| .. |.|  |  . |
vaDgmGkGlaAaaassqlrtalrellseg........eelsqalkrlnraiyeekeekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd

hkpfspkeqeriqnaggsvmikringtlavsrafgdydfkndgsksPVDQMVSPEPDI---IVCNRSEHDEFIVVACDGIWDVMTS-----SEVCEFIRS
                                              .  .... ||..   |     | ..... . ||.......      ...|....
..............................................vegaplGlepevsvdirelelekgdllllytDGltearsekgfaeerleeiled

RLlvTYDLPMIVN-SVLDICLHKGSR---DNMTLLLL
 .  .  .  . .  | ... ... .   |..|....
lv..dseaqelaqkiveellelakgsngeDdiTvvvv
subfamily_TAB1_pd Subfamily TAB1 108-197 5.9e-10 31.4 In-house 119-214 (333) alignment 
Range on Protein: 108-197
Range on HMM: 119-214/333.0
DMRKLYHDQQGGSTAICVFVSPDKIYLVNCGDSRAVISR---NGAAVISTIDHKPFSPKEQERIQNAGGS-VMI--KRINGTLAVSRAFGDYDFKN
 ...| .. .||.||. . .  .|.| .|.|||||.. .   .   .    ||.   ..| .|... |     |  ... |     |. |||  |.
rlqeleeeisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkk
PP2C_2 Protein phosphatase 2C 65-239 1.9e-08 26.9 Pfam-A 39-183 (212) alignment 
Range on Protein: 65-239
Range on HMM: 39-183/212.0
GHAGSQISLHCAEHLMSTILESESFS-KHKYEAGIREGFLQ----LDEDMRKLYHDQQGGSTAICVFVSPDKIYLVNCGDSRA-VISRNGAAVISTIDHK
.. |...  . | . ....||.||.. . .    |... |.     .| . . .  .. ..| ......|..|.....||... |..|.| . . .....
SdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepds

PFSPKEQERIQNA--GGSVmikringtlavsrafgdydfkndgskspvdqmvspepDIIVCNrSEHDEFIVVACDGIWDVMTS
     |  ... .  ....                                     .|. ..  |  . ...  ||..| ...
geyanettfltsedaeeel.....................................rirrlk.lepgdalllmTDGvsdslrk
PP2C_2 Protein phosphatase 2C 65-239 1.9e-08 26.9 In-house 39-183 (212) alignment 
Range on Protein: 65-239
Range on HMM: 39-183/212.0
GHAGSQISLHCAEHLMSTILESESFS-KHKYEAGIREGFLQ----LDEDMRKLYHDQQGGSTAICVFVSPDKIYLVNCGDSRA-VISRNGAAVISTIDHK
.. |...  . | . ....||.||.. . .    |... |.     .| . . .  .. ..| ......|..|.....||... |..|.| . . .....
SdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepds

PFSPKEQERIQNA--GGSVmikringtlavsrafgdydfkndgskspvdqmvspepDIIVCNrSEHDEFIVVACDGIWDVMTS
     |  ... .  ....                                     .|. ..  |  . ...  ||..| ...
geyanettfltsedaeeel.....................................rirrlk.lepgdalllmTDGvsdslrk
Subfamily Dicty-PPM1L-like 205-283 6.2e-07 21.5 In-house 217-303 (305) alignment 
Range on Protein: 205-283
Range on HMM: 217-303/305.0
DQMVSPEPD--IIVCNRsEHDEFIVVACDGIWDVMTSSEVCEFIRSRLLVT-------YDLPMIVNSVLDICLHKGSRDNMTLLLLLL
 ..| |..|  . | ..   |.|.|.| ||.|.|.   .| |...  |  .       .|   | . .    ...||.||.||... |
kelviPnndspllvvak.anDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgDnitlviikl
Subfamily Dicty-PPM1L-like 117-192 1.7e-06 20.0 In-house 210-294 (305) alignment 
Range on Protein: 117-192
Range on HMM: 210-294/305.0
QGGSTAICVFVSPD---KIYLV-NCGDSRAVISRNGAAVISTIDHKPFSPKEQERIQNAGG-----SVMIKRINGTLAVSRAFGD
. |   .  .| |.   ... | . .|.. |....| . .   ....  .||  |..  ..        | |. . .||.|  ||
skGdknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgD