Gene CG10417 in Drosophila melanogaster

Synonym: Dmel\CG10417, PP2Cg, Dmel_CG10417, CG10417

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1G
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP131_AA protein Get Run
DmelP131_AA_17-564 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1G_pd Subfamily PPM1G 4-566 1.4e-168 554.8 In-house 1-472 (473) alignment 
Range on Protein: 4-566
Range on HMM: 1-472/473.0
YLSHPKTDKTSTDQFNELLAVGASSMQGWRNSQEDAHNSILNFDNNTSFFAVYDGHGGAEVAQYCADKLPHFLKNLETYKNGQFEVALKEAFLGFDKTLL
|||.||..|.|.|..|| |..|||.|||||.|||||||.|...|..||.|||||||||.|||.|.|.|||..||. ..||.|..| ||.|||| .|..| 
ylskpkvekesedesneelsygasamqGwrvsqEDahncitdldedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDeklk

DPSIVSILKILAGEHNFVDA--EADDYEEEDLAELQEESNLPLNEVLEKYkglpqkkdldlkssdhkenfkmrspyfrgrraaalaaeatnkavmdpsak
   ..  || .|. ..  |   | |. .|.. . |.||...||.|.|...                                                  
aeeslkelkeiaeaeededeeeeddeededeiellteeaeipldellkrl..................................................

pdgsstsaaaaaaalsadgvansrnpsnvvnpmAGADSNTTTSINdLSTKNAAlKDDSVNDQNEGSNGTDFKHTLVSSSN-KKLFATGSNDMTELNQSSK
                                  |. |....  .   ...|| ..|. .....  .  . |.|  .|.. .|  ... ..  | ..  .
.................................dgdgsekeelsq.allegaa.sedeedededeeeeeeekdteeeskeeekkakaakegkqekkeede

NEFTNSSTSKEferninssqddefTDDDADYEENDNVKSPDTSSAESSDCTENDDDGDEDGNEDSDEE-ETDEDQMANDNF-CANMIEEPGKDSGCTAVV
.| .... .||             .... . .|... ...| .. |..| .|.... .| ..||..|| |..|.. |. .    .  ||||.|||.||||
sekeeeeeeke.............eeeedekgeteeeeeededeeeeedeeeaeeeeeeedeedeeeeeedgegeeakeeldgseekeepGedsGttAvv

CLLQGRDLYVANAGDSRCVISRSGQAIEMSIDHKPEDDEEASRIIKAGGRVTLDGRVNGGLNLSRALGDHAYKTNVTLPAEEQMISALPDIKKLIITPED
.||....|.||||||||||.||.|.|...|.||||||..|..|| ||||.|. ||||||||||||||||||||.| .||..|||||||||||.|..|.||
aLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDikvltlteed

EFMVLACDGIWNYMSSEEVVEFVRCRLKDNK--KLSTICEELFDNCLAPNTMGDGTGCDNMTAVIVQFKK
||.|||||||||.|.|.|||.|||..||...  .||.|.|||.|.||||.|.||||||||||..||..||
eFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllkk
subfamily_PPM1G2_pd Subfamily PPM1G2 387-564 8.6e-69 224.6 In-house 112-286 (287) alignment 
Range on Protein: 387-564
Range on HMM: 112-286/287.0
EpgKDSGCTAVVCLLQGRDLYVANAGDSRCVISRSGQAIEMSIDHKPEDDEEASRIIKAGGRVTLDgRVNGGLNLSRALGDHAYKTNVTLPAEEQMISAL
.  ...|.|||| |.. ..||||||||||.|.| .|..  .|.||||.. .|..|||.||| | |. |||| | |||||||...|.||....|||.. |.
d..esaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfveln.rvngnLalsralgDfefkknvkkkpeeqivtav

PDIKKLIITPEDEFMVLACDGIWNYMSSEEVVEFVRCRLKDNKKLSTICEELFDNCLAPNTMGDGTGCDNMTAVIVQF
||.    ....|||.||||||||. ....|||..|| ||....||..|.|||.|.||||..   | ||||||.||| .
PDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl
PP2Cc_SM00332 359-562 9.1e-67 218.3 In-house 86-274 (274) alignment 
Range on Protein: 359-562
Range on HMM: 86-274/274.0
EDGNEDSDEEETDEDQMANDNFcanmieepgKDSGCTAVVCLLQGRDLYVANAGDSRCVISRSGQAIEMSIDHKPEDDEEASRIIKAGGrVTLDGRVNGG
... .. ||| ..| |. ....          .||.||||.||.. ||||||.||||.|..|.|.|...| |||||| .| .|| |||| |. .||||||
kkaflstdeeileeeqskelen.........alsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkagg.vvekgrvngg

LNLSRALGDHAYKTNVtlPAEEQMISALPDIKKLIITPEDEFMVLACDGIWNYMSSEEVVEFVRCRL-KDNKKLSTICEELFDNCLAPNtmgdGTGCDNM
|..|||.|||..|.|   . .|..|.|.||.| . .|.||||..||.||.|...|..|||..|| .| | ...  . ..|| |......    |...||.
lavsrafGdhflkknk..klkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairr....ggseDni

TAVIV
|.|.|
Tvvvv
PP2C Protein phosphatase 2C 354-548 1e-61 201.7 Pfam-A 70-252 (255) alignment 
Range on Protein: 354-548
Range on HMM: 70-252/255.0
DddGDEDGNEDSDEEetDEDQMANDNFCAnmiEePGKDSGCTAVVCLLQGRDLYVANAGDSRCVISRSGQAI-EMSIDHKPEDDEEASRIIKAGGRVTLD
.   .|..  .| ..  |.|.. ... ..   .    .||.||||.|..| .|||||.||||.|..|...|. |.. ||||.|..|..|| .|||.|   
e..kvekalrksfla..dtdeelksskan...t.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnn

GRVNGGLNLSRALGDHAYKTNVtlpaeEQMISALPDIKKLIITPEDEFMVLACDGIWNYMSSEEVVEFVRCRLKDNKKLSTICEELFDNCLAPNTM
||||| |..||||||. .| ..     ||..|| ||...  .|.||||..||.||.|...|..|.|..|| .|...|......||| |...|....
grvngsLavsRalGdfelkpke.....eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargse
PP2C Protein phosphatase 2C 354-548 1e-61 201.7 In-house 70-252 (255) alignment 
Range on Protein: 354-548
Range on HMM: 70-252/255.0
DddGDEDGNEDSDEEetDEDQMANDNFCAnmiEePGKDSGCTAVVCLLQGRDLYVANAGDSRCVISRSGQAI-EMSIDHKPEDDEEASRIIKAGGRVTLD
.   .|..  .| ..  |.|.. ... ..   .    .||.||||.|..| .|||||.||||.|..|...|. |.. ||||.|..|..|| .|||.|   
e..kvekalrksfla..dtdeelksskan...t.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnn

GRVNGGLNLSRALGDHAYKTNVtlpaeEQMISALPDIKKLIITPEDEFMVLACDGIWNYMSSEEVVEFVRCRLKDNKKLSTICEELFDNCLAPNTM
||||| |..||||||. .| ..     ||..|| ||...  .|.||||..||.||.|...|..|.|..|| .|...|......||| |...|....
grvngsLavsRalGdfelkpke.....eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargse
PPM_PTC7 371-548 5.6e-60 196.0 In-house 71-256 (259) alignment 
Range on Protein: 371-548
Range on HMM: 71-256/259.0
DEDQMANDNFCA------------NmiEePGKDSGCTAVVCLLQGRDLYVANAGDSRCVISRSGQAI-EMSIDHKPEDDEEASRIIKAGGRVT--LDGRV
. ..  .. |.|            |  .   ..||.||||.|..| .|||||.||||.|..|||.|. ... ||||.. .|..|| .|||.|    .|||
klekalrksflaldtdeelkssean..t.epstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrv

NGGLNLSRALGDHAYKTNVTlpaEEQMISALPDIKKLIITPEDEFMVLACDGIWNYMSSEEVVEFVRCRLKDNkKLSTICEELFDNCLAPNTM
|| |..|||.||. .| ..|   |||..|| |||..  |..||||..||.||.|...|..|.|..|| .|... ... ..|.| | ..|....
ngvlavsRafGdfelkpket...eeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargse
0034914 PP2C-like 388-565 1.7e-59 194.0 In-house 120-291 (295) alignment 
Range on Protein: 388-565
Range on HMM: 120-291/295.0
PGKDSGCTAVVCLLQGRDLYVANAGDSRCVISRSGQAIEMSIDHKPEDDEEASRIIKAGGRVTLdGRVNGGLNLSRALGDHAYKTNVTLPAEEQMISALP
    ||.||||.|..|. |||||.||||.|..|.|... ...|||| . .|  ||..|||.|.  |||||.|...|||||. .|.. .|...|...|| |
elagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh.grvngvlavtRalGdfdlklllslllleplvsaeP

DIKKLIIT-PEDEFMVLACDGIWNYMSSEEVVEFVRCRLKDNKKLSTICEELFDNCLApntmgdGTGCDNMTAVIVQFK
|.. | .| ..|.|..||.||.|...|.||.|..|| .|. .. |. ..||| | .||      . ..||.|.|.|...
dvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla......rgsrDNiTvvvvrln
subfamily_PPM1A_pd Subfamily PPM1A 361-565 5.2e-58 189.6 In-house 115-281 (282) alignment 
Range on Protein: 361-565
Range on HMM: 115-281/282.0
GnedsdeeetdedqmandnfcanmieepgkdsGCTAVVCLLQGRDLYVANAGDSRCVISRSGQAIEMSIDHKPEDDEEASRIIKAGGRVTlDGRVNGGLN
                                |.|||..|.. . |..||.|||| |..| |.|. .. ||||....|  || .||| |.  .|||| | 
s...............................GsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv.vsRvnGaLA

LSRALGDHAYKTNVTLPAEEQMISALPDIKKLIITPEDEFMVLACDGIWNYMSSEEVVEFVRCRLKDNKKLSTICEELFDNCLAPNTMgdgtgcDNMTAV
.||||||..||.. ...||||..|| |... . .. ||.|.||||||||  .|.|||||.|| ||. ...|......| |..|  ..       ||....
vsRalGDyeykeeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsr......DNlsvl

IVQFK
.| |.
vvlfa
0049733 PP2C-like 377-565 2.1e-42 138.1 In-house 76-234 (235) alignment 
Range on Protein: 377-565
Range on HMM: 76-234/235.0
NDNFCANMIEE-PGKDSGCTAVVCLLQGRDLYVANAGDSRCVISRSGQAIEMSIDHKPEDDEEASRIIKAGGRVtldgRVNGGLNLSRALGDHAYKtnvt
|. ...  ... .   .|.||||.||.|. |||||.||||... |.|... .. ||.| ...|  |||.|||.|    ||.|.| |.|||||. .|    
neallelalaspelagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav....rvpgrlaltralGdlllk....

lpaeeqmisalPDIKKLIITPEDeFMVLACDGIWNYMSSEEVVEFVRCrlkdnKKLSTICEELFDNCLApntmgdGTGCDNMTAVIVQFK
           ||.  | ..|.| |..||.||.|...|.||.|...|      . |. ..|.|.. .||      . |.||.|.|.|...
...........pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelala......rggrDNiTvvvvrld
subfamily_PPM1E_pd Subfamily PPM1E 374-565 1.9e-37 121.9 In-house 85-263 (265) alignment 
Range on Protein: 374-565
Range on HMM: 85-263/265.0
QMANDNFCANMIEEpGKDSGCTAVVCLLQGRDLYVANAGDSRCVISRSGQAIEMSIDHKPEDDEEASRIIKAGGRVTLDG--RVNGGLNLSRALGDHAYK
......|..  ..| .  ||.||||.|.... ||||  |||. .. | |.|...   ||||...|..|| .||| |   |  |||| |..|||.||  .|
kltDerflqkaere.klksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk

tnvtlpaeeQMISALPDIKKLIITPEDEFMVLACDGIWNYMSSEEVVEFVRCRLKDNK-KLSTICEELFDNCLapntmgDGTGCDNMTAVIVQFK
         ...|. .|. .. .. ..|...|||||.|. .  ||||. |.  |.|.. .||.. ..| ..        .    ||.|.|.| ..
.........pyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaak......eagssDnitvvvvfld
subfamily_ILKAP_pd Subfamily ILKAP 386-534 5.7e-33 107.3 In-house 107-252 (293) alignment 
Range on Protein: 386-534
Range on HMM: 107-252/293.0
EEPGKDSGCTAVVCLLQGRDLYVANAGDSRCVISRSGQ------AIEMSIDHKPEDDEEASRIIKAGGRVTlDGRVNGGLNLSRALGDHAYKTNvtlpae
..|    |.||.|.|     ||||| |||..|. |  .      .. .. ||.| . ||  || |||| |. ||||.| |. ||..||  .|.       
akPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvr.dgrvlGvlevsrsiGdgrfkrl......

eqMISALPDIKKLIITPEDEFMVLACDGIWNYMSSEEVVEFVRCRLKDNKKLSTI
   ... ||.||. .|. | |.||||||.|. .| .|||.|.   |.|... ..|
..GvistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrki
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 384-542 1.1e-31 103.1 In-house 87-237 (255) alignment 
Range on Protein: 384-542
Range on HMM: 87-237/255.0
MIEEPGKDSGCTAVVCLLQGRDLYVANAGDSRCVIS-RSGQAIEMSIDHKPEDDEEASRIIKAGGRVTLD---GRVNGGLNLSRALGDHAYKTNVTlPae
.|.| .|  |.||.. |. .   |.|| |||| |.. . | |  .|.|||| ...|  || ..|| |  .    |||| | .||||||   .  |. |  
qiserpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvv.p..

EQMISAlpdikKLIITPEDEFMVLACDGIWNYMSSEEVVEFVRCRLKDNKklstICEELFDNC
.  .|      .| |. .|.|..|||||||. .| || || |    . .|     .|.| |  
dPdlsq.....sleiskkdkflilacdGiwdlisdeeaveivagisdpek....aaeklrdla
subfamily_PPM1L_pd Subfamily PPM1L 373-529 1.7e-30 99.2 In-house 87-240 (269) alignment 
Range on Protein: 373-529
Range on HMM: 87-240/269.0
DQMANDNFCANMIEEPGKDSGCTAVVCLLQGRDLYVANAGDSRCVI-SRSGQAIEMSIDHKPEDDEEASRIIKAGGRVTLDG--RVNGGLNLSRALGDHA
. .. |.   . ..   . .|.||.. |.|..|| ||| |||| |.  ..|.|| .| ||||.. .|  || |||| ....|  ||.| |  ||||||. 
eilsvdekllekakraediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyp

YKtnvtlpaEEQMISALPDIKKLIIT-PEDEFMVLACDGIWNYMSSEEVVEFVRCRLKDNK
 |       ..... | |||  . .   . ||..||.||.|. .| || |.|.. |||. .
lk.......dknlviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepd
PPM_PTC7_SpoIIE 377-544 2.9e-30 98.8 In-house 77-223 (230) alignment 
Range on Protein: 377-544
Range on HMM: 77-223/230.0
NDNFCANMIEEpGKDSGCTAVVCLLQGRD--LYVANAGDSRCVISRS-GQaiemsidhkpeddeEASRIiKAGGRVT---LDGRVNGGLNLSRALGDHAY
|....|.. .|  ..||.||||.|... .  |||||||||.....|. |.              |. || .||| .    |.|||.| |..|.| ||  .
nlalaadlede.psssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdlll

KTnvtlpaEEQMISALPDiKKLIITPE-DEFMVLACDGIWNYMSSEEVVEFVRCRLKDNkklstICEELFDNCLA
.       ......| ||  . ..... |||..||.||.|...|..|.|..|| .|...     ..|.| . ...
ly......tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeglleDDit
subfamily_PPM1K_pd Subfamily PPM1K 386-539 4.7e-28 91.0 In-house 92-243 (263) alignment 
Range on Protein: 386-539
Range on HMM: 92-243/263.0
EEPGKDSGCTAVVCLL-QGRDLYVANAGDSRCVISRSGQAIEMSIDHKPEDDEEASRIIKAGGRVTLD----GRVNGGLNLSRALGDHAYKTNVtlpaee
|.  . || || |.|| .| .| .|. |||| .. | |.|  ...||.|| .||  || .|||.|. .     .||| | ..|.|||   |.        
eaellssGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryG......

qmISALPDIKKLII-TPEDEFMVLACDGIWNYMSSEEVVEFVRCRLKDNKKLSTICEELF
  . | |. |.| .   .| |.||  ||| . ..|.|. ..||   . ..  ....|  .
..viatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrlchdpeeaahalteqal
subfamily_PPM1G2_pd Subfamily PPM1G2 5-104 1.9e-27 88.9 In-house 2-106 (287) alignment 
Range on Protein: 5-104
Range on HMM: 2-106/287.0
LSHPKTDKTSTDQFNELLAVGASSMQGWRNSQEDAHNS---ILN--FDNNTSFFAVYDGHGGAEVAQYCADKLPHFLKNLETYKNGQFEVALKEAFLGFD
||.| ..| |.   |.| .||.|.|||.| ..||||     .|.   |.....|||.||||||.||.|.. || ..... ...|.|. | .||.||| .|
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletD

KTLLD
. || 
eellk
subfamily_KAPP-like_pd Subfamily KAPP-like 390-563 1e-25 83.3 In-house 98-265 (266) alignment 
Range on Protein: 390-563
Range on HMM: 98-265/266.0
KDSGCTAVVCLL----QGRDLYVANAGDSRCVISRSGQAIEMSIDHKPEDDEEASRIIKAGGRVTLD-GRVNgGLNLSRALGDHAYKT-NVTLPAeEQMI
.  |.|| ..|.    | | | ||| |||   .||  ...|.| ||| .|.||  || . |  .. .  |.| || .|||||||  |  |. | . |  .
eyeGatatlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrin.GlavsralGdhfikelniGlis.epyv

SalpdiKKLIITPEDEFMVLACDGIWNYMSSEEVVEFVRCrLKDNKKlstiCEELFDNCLAPNTMGDGTGCDNMTAVIVQ
|     .....|| |.|...| ||.|. .| .. .| |.. | |...     |. . ..|   ...     ||.. ..|.
s.....nrilltpfdkflivasdGlwdvisGkdaiekvks.lydqqa....tedkmasslletaiqsikakdnvsvivvk
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 368-563 4.3e-24 77.8 In-house 79-275 (276) alignment 
Range on Protein: 368-563
Range on HMM: 79-275/276.0
EETDEDQMANDNFCA--NMIEEpGKDSGCTAVVCLL--QG--------RDLYVANAGDSRCVISRSGQAIEMSIDHKPEDDEEASRIIKAGGRVTLD-GR
.  |  .. .| |    . ...  .  |.|| ..|.  .|        | | ||| |||   .||  ...|.| ||| .| ||  || . |  .. .  |
niydqskllldlfkevdaklkd.feyeGatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtr

VNgGLNLSRALGDHAYKT-NVTLPAeEQMISalpdiKKLIITPEDEFMVLACDGIWNYMSSEEVVEFVRCrLKDNKKlstiCEELFDNCLAPNTMGDGTG
.| || .|||||||  |  |. | . |  .|     .....|| |.|...| ||.|. .| .. .| |.. | |...     |. . ..|   ...    
in.GlavsralGdhfikelniGlis.epyvs.....nrilltpfdkflivasdGlwdvisGkdaiekvks.lydqqa....tedkmasslletaiqsika

CDNMTAVIVQ
 ||.. ..|.
kdnvsvivvk
subfamily_PDP_pd Subfamily PDP 333-534 1.1e-23 77.0 In-house 106-321 (398) alignment 
Range on Protein: 333-534
Range on HMM: 106-321/398.0
ENDNVKSPDTSSAESSDCTENDDDGDEDGNEDSdeeetdedqmaNDNFCANMIEEpgKDSGCTAVVCLLQGRDLYVANAGDSRCVISRS---G--QAIEM
|. ...  ....| ..  .. |.|  ..  ...           ...  .....     || .|.. |..|..|.|||.||.|.|. ..   |  .|...
elleaevekvkealkkaFlklDkdistealkkl...........kekslreallv..alsGacallaliegtelhvAntGDcravlgvqeeegsweavkL

SIDHKPEDDEEASRIIKAGG-----RVTLDGRVNGGLNLSRALGDHAYKTNVTLPA---EE-------Q-------MISALPDIKKLIITPEDEFMVLAC
|.|.  .  || .|| |.        |  .||. | |  .|| ||  || .  |     |.                ..| |.. .  ....| |.||| 
skdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlat

DGIWNYMSSEEVVEFVRCRLKDNKKLSTI
||.|. .|.||||. |   |...|. . .
DGLwdllsneevvslVgehlakkkekepv
PP2Cc_SM00332 17-104 1.1e-22 73.7 In-house 5-98 (274) alignment 
Range on Protein: 17-104
Range on HMM: 5-98/274.0
QFNELLAVGASSMQGWRNSQEDAHNSILNFD--NNTSFFAVYDGHGGAEVAQYCADKLPHFLKNLETYKNG----QFEVALKEAFLGFDKTLLD
. |  |. | |||||||.|.||||.......  ....||.|.|||||.|||.....|||..||.   .|..    . | |||.||| .|. .|.
gsnlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeile
0034914 PP2C-like 3-108 7.8e-22 70.7 In-house 2-117 (295) alignment 
Range on Protein: 3-108
Range on HMM: 2-117/295.0
AYLSHPKTDKTSTDQFNELLAVGASSMQGWRNSQEDAHNSILNF---DNNTSFFAVYDGHGGAEVAQYCADKLPHFLKN-------LETYKNGQFEVALK
..||.|.......  .. || ||..|.||.|.|.|||.  .||.   ......|.|.||||| ..|..... |...|..       | |.   ..| ||.
lllslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealr

EAFLGFDKTLLDPSIV
.|||  |. ||. .. 
kaflaadeellelall
subfamily_PPM1D_pd Subfamily PPM1D 391-565 7.4e-21 67.5 In-house 107-308 (309) alignment 
Range on Protein: 391-565
Range on HMM: 107-308/309.0
DSGCTAVVCLLQGRDLYVANAGDSRCVISRSGQ------AIEMSIDHKPEDDEEASRIIKAGGRVTLD---GR---------VNGG--------LNLSRA
 .| || | ......||||. |||. |.. . .      | |.  |||||. ||  || ..||.|.      |          ||         |...|.
taGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLavaRs

LGDH-AYKTNvtlpAEEQMISALPDIKKLIITPEDE-FMVLACDGIWNYMSSEEVVEFVRCRLKDNKKL----STICEELFDNCLApNTMGDGTGCDNMT
|||  .|...     .| ..|  ||.|.  ..|..| |..|| ||.|| ...|..|..|.   . ..      ... . | .. |  ..      .||..
lGDlWsynak....sgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealq.rwrskklraDnvs

AVIVQFK
...| ..
vivvile
subfamily_PP2D1_pd Subfamily PP2D1 404-655 8.5e-21 67.2 In-house 188-434 (492) alignment 
Range on Protein: 404-655
Range on HMM: 188-434/492.0
RDLYVANAGDSRCVISRSGQAIEMSIDHKPEDDEEASRIIKAGGRVTL---DGRVNGGLNLSRALGDHAyktNVTLpaeEQMISALPDIKKLIITPEDEF
  ||.||||. . |. | |.|| .  .| |.. .| .|. |||. |.     |.||| |.  | || .    .  |   .. .   | ..   .. .. |
gvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyG...dpkL...kksvipePkttsvkldeaaqf

MVLACDGIWNYMSSEEVVEFVRCRLKDNKKlSTICEELFDnCLAPNTMGDGTGCDNMTAVIVQFKKKLQELQSTIPPNQTEDKLLKTSENVSHSLNDQSA
.|||  |.|. .| |||.. |.  |.  |. ..  | ..|    .    |. |  ... .  .....  .  .|  .. .  .  ..  .. .|.|. | 
lvlAsnGlWevlseeevlsLvkqtlaiyks.rvraenvpd.sdvttvgedylgEleakklsaryentgfdkfvtseidldaaegdesnlqklfsynelse

SKRCASQNADADDEILEKNNSKRLKTDLEQENIKDRTPSPSNQNEDPTQKAIKEV
 |. | .. ....|   |..  . . | ........  ..|... .  .  ..||
vkedaddereglseanskkeityneedtdksaeeskeaksseekstnrsirveev
subfamily_PPM1A_pd Subfamily PPM1A 20-97 8e-19 61.0 In-house 10-97 (282) alignment 
Range on Protein: 20-97
Range on HMM: 10-97/282.0
ELLAVGASSMQGWRNSQEDAHNSILNFDNN--TSFFAVYDGHGGAEVAQYCADKLPHFLKNLETYK--------NGQFEVALKEAFLG
. | .| |||||||.. ||||. . .. .    |||||.|||.|.|||.|....|.. . . |..|        . . . ||...|| 
nglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLa
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 390-469 1.8e-17 56.8 In-house 82-184 (292) alignment 
Range on Protein: 390-469
Range on HMM: 82-184/292.0
KDSGCTAVVCLL--QGRDLYVANAGDSRCVISR-----SGQAIEMSIDHKPEDDEEASRIIKAGGRVT--------L--DGRV------NGGLNLSRALG
. |. |||||     .| |..|| ||||... |       . | .| |||||| .| .|| .|||||.             ||      .|.| ||||||
resattavvcarvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralG

DHA
|  
dfh
PP2C Protein phosphatase 2C 23-102 2.6e-15 49.7 Pfam-A 2-88 (255) alignment 
Range on Protein: 23-102
Range on HMM: 2-88/255.0
AVGASSMQGWRNSQEDAHNSILNF-----DNNTSFFAVYDGHGGAEVAQYCADKLPHFLKNLETYKNG-QFEVALKEAFLG-FDKTL
.||||..||.| | |||| .. |.     ... .||||.||||| |.|.|.. .|. .||. .. . . . | ||...||  .|..|
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeel
PP2C Protein phosphatase 2C 23-102 2.6e-15 49.7 In-house 2-88 (255) alignment 
Range on Protein: 23-102
Range on HMM: 2-88/255.0
AVGASSMQGWRNSQEDAHNSILNF-----DNNTSFFAVYDGHGGAEVAQYCADKLPHFLKNLETYKNG-QFEVALKEAFLG-FDKTL
.||||..||.| | |||| .. |.     ... .||||.||||| |.|.|.. .|. .||. .. . . . | ||...||  .|..|
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeel
PPM_PTC7 24-104 5.3e-15 48.6 In-house 3-91 (259) alignment 
Range on Protein: 24-104
Range on HMM: 3-91/259.0
VGASSMQGWRNSQEDAHNSILNF-----DNNTSFFAVYDGHGGAEVAQYCADKLPHFLKNLETYKNG-QFEVALKEAFLG--FDKTLLD
.|||..||.| | |||| .  |.     ... .||||.||||| |.|.|.. .|. .||. .. ...   | ||...||   .|..| .
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelks
PPM_PTC7_motif 502-547 5.5e-15 48.6 In-house 1-47 (51) alignment 
Range on Protein: 502-547
Range on HMM: 1-47/51.0
VLACDGIWNYMSSEEVVEFVRCRLK-DNKKLSTICEELFDNCLAPNT
.||.||.|...|..|.|..|| .|. .....  ..|.| |..||...
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargs
subfamily_PHLPP_pd Subfamily PHLPP 405-523 5.9e-15 47.8 In-house 106-214 (246) alignment 
Range on Protein: 405-523
Range on HMM: 106-214/246.0
DLYVANAGDSRCVISRSGQAIEMSIDHKPEDDeEASRIIKAGGRVTLDGRVNGGLNLSRALGdHAYKTNVTLPAeeqmisalPDIKKLIITPEDEFMVLA
 | ||. |    |. | |. . .|  .. |.| |..|| .| . .| |...|| .. .| || . .   | ||         | ......|..||.... 
sLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitednkingviestrllG.ytflfPvvlPk........phvrevlLteqdellivG

CDGIWNYMSSEEVVEFVRC
 . .|. .| .|.|| || 
nkalWevlsideaveavrk
subfamily_TAB1_pd Subfamily TAB1 392-512 3e-14 45.5 In-house 129-260 (333) alignment 
Range on Protein: 392-512
Range on HMM: 129-260/333.0
SGCTAVVCLLQGRDLYVANAGDSRCVISR---SGQAIEMSIDHKPEDDEEASRIIKAGG---RVTLDGRVnGGLNLSRALGDHAYK-----TNVTLPAEE
 | |||| |.   .|||||.|||| .. .   | .   .| ||. . ..|  |. . |    ..   .|. |. .  |..||.  |     ...   |..
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrl.gskentRsiGdykvkkgykdvdilssakg

QMISALPDIKKL-IITPEDEFMVLACDGIWNYM
. . | |||.    |..   |.||  ||. . .
ePviaePdiqgaypiddityflvlmSdGvyktL
subfamily_PPM1H_pd Subfamily PPM1H 389-437 1e-13 43.8 In-house 159-207 (404) alignment 
Range on Protein: 389-437
Range on HMM: 159-207/404.0
GKDSGCTAVVCLLQGRDLYVANAGDSRCVISRSGQAIEMSIDHKPEDDE
 .  ||||.| |.    |||||||||| ...|... |..| |. || . 
rikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPeteR
subfamily_PPM1K_pd Subfamily PPM1K 23-102 1.8e-13 43.2 In-house 5-82 (263) alignment 
Range on Protein: 23-102
Range on HMM: 5-82/263.0
AVGASSMQGWRNSQEDAHnSILNFDNNTSFFAVYDGHGGAEVAQYCADKLPHFLKNLEtYKNGQFEVALKEAFLGFDKTL
.||  |..| |.  ||   .....|..  ..||.|||.|.  |... ||| . ||.|   |. ..|. ||.||.  || |
svGkdsliGkraenedri.klkeldpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkkl
0049733 PP2C-like 23-107 5.6e-13 42.0 In-house 4-84 (235) alignment 
Range on Protein: 23-107
Range on HMM: 4-84/235.0
AVGASSMQGW-RNSQEDAHNSilnfdnNTSFFAVYDGHGGAEVAQYCADKLPHFLKNL-ETYKNGQFEVALKEAFLGFDKTLLDPSI
 |||.|..|. |. .|||.        ....|||.|||||......... |...|..| ...   . | ||..|||  .. ||. ..
svgaasdigrvrkvneDavlv......glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelal
PP2C_SIG_SM00331 387-564 7e-13 41.6 In-house 81-217 (217) alignment 
Range on Protein: 387-564
Range on HMM: 81-217/217.0
EPGKDSGCTAVVCLL--QGRDLYVANAGDSRCVISRSGQAIEMSIDhkpeddeeasriikaggrvtldgrvngglNLSRALGDHAYKTnvtlpaeeqmis
.  |....|....|.  ... |..|||||||... |.|. .|   |                             .....|| .   .            
keekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd.............................vegaplGlepevs............

alPDIKKLIITPeDEFMVLACDGIWNYMSSEE-----VVEFVRCRL-KDNKKLST-ICEELFDNCLAPNTmgdgtgCDNMTAVIVQF
  .||..|.. . .....|. ||... .|...     . |...  .    ..|.. | |||. .  ..|.       |..| |.|..
..vdirelelek.gdllllytDGltearsekgfaeerleeiledlvdseaqelaqkiveellelakgsng......eDdiTvvvvkv
subfamily_PPM1E_pd Subfamily PPM1E 28-106 8.8e-12 37.7 In-house 10-95 (265) alignment 
Range on Protein: 28-106
Range on HMM: 10-95/265.0
SMQGWRNSQEDAHNSILN--------FDNNTSFFAVYDGHGGAEVAQYCADKLPHFLKNLETYKNGQFeVALKEAFLGFDKTLLDPS
.... |  .|| | .. .        ......||||.||||| | |.| | .|...| . |. |.     ||||||   |...|  .
avknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.ealkeafkltDerflqka
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 23-99 3e-10 32.8 In-house 7-85 (255) alignment 
Range on Protein: 23-99
Range on HMM: 7-85/255.0
AVGASSMQGWRNSQEDAHNSILNFDNN--TSFFAVYDGHGGAEVAQYCADKLPHFLKNLETYKNGQFEVALKEAFLGFD
 || | | | |.. ||      .| ..    ..|..||||| . |......|.. |..|   .| . . .||.|.   .
kvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeis
subfamily_PPM1D_pd Subfamily PPM1D 24-101 2.2e-09 29.9 In-house 4-89 (309) alignment 
Range on Protein: 24-101
Range on HMM: 4-89/309.0
VGASSMQGWRNSQEDAHNSILNFDNN-----TSFFAVYDGHGGAEVAQYCADKLPHFLKNLETYKN---GQFEVALKEAFLGFDKT
| ... || |.  ||     |. ...      .|.||.||||| | |..  ..| ...|. . . .    .   |..||||   ..
vtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflathea
Subfamily Dicty-PPM1L-like 436-564 2.9e-09 29.2 In-house 180-303 (305) alignment 
Range on Protein: 436-564
Range on HMM: 180-303/305.0
DEEASRIIKAGGRVTLDGRV--NGGLNLSRALGDHAYKTNVTlPAEEQMISAlpdikklIITPEDEFMVLACDGIWNYMSSEEVVEFVRCRLKDNKK---
||.  ||  ... .   |..  |. |. ||  ||   |  |  | ... .         .  ..|.|.||| ||.|. .| ..|||.|.  |.|...   
deiririeslqaalynygellvnrllkksrskGdknlkelvi.Pnndspllv.......vakanDqflvlatdGlwevlsyqdvveevkellrdkssqkk

LSTICEElFDNCLAPNTMGDGTGcDNMTAVIVQF
.    .|   .  . ...  | | ||.| ||...
iewdfne.isrviveeavkrgsg.Dnitlviikl
PPM_PTC7_SpoIIE 24-98 5.5e-09 29.2 In-house 3-80 (230) alignment 
Range on Protein: 24-98
Range on HMM: 3-80/230.0
VGASSMQGWRNSQEDAHNSILNF-----DNNTSFFAVYDGHGGAEvaQYCADKLPHFLKNLEtYKNGQ-FEVALKEAFLGF
.|||..||.| | |||| |  |.     ..   .....||||| .  ....  |  .|..|  .....  | .|....| .
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlal
subfamily_PPM1L_pd Subfamily PPM1L 24-79 1.5e-08 27.2 In-house 7-65 (269) alignment 
Range on Protein: 24-79
Range on HMM: 7-65/269.0
VGASSMQGWRNSQEDAHNSILNFDNNT--SFFAVYDGHGGAEVAQYCADKLPHFLKN-L
| . |..| |.  ||  .   . .|.|  |||||.|||||   |... |.|.. .|| |
vavysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknkl
PPM_PTC7_SpoIIE_motif 496-564 2.3e-08 27.6 In-house 10-80 (81) alignment 
Range on Protein: 496-564
Range on HMM: 10-80/81.0
PEDEFMVLACDGIW-------NYMSSEEVVEFVRCRlkDNKKLSTICEELFDNCLApntMGDGTGCDNMTAVIVQF
.... ..|..||..       . .. ||...... .  . |.|  ....|.|..|.   .|.|   |..| .....
kpgdvllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevle...ngsgereDDitllvlrv
subfamily_PPM1H_pd Subfamily PPM1H 454-529 2.9e-08 25.9 In-house 276-355 (404) alignment 
Range on Protein: 454-529
Range on HMM: 276-355/404.0
RVNGGLNLSRALGDHAYKTNVTLPAEEQMISALPDIKKLII----TPEDEFMVLACDGIWNYMSSEEVVEFVRCRLKDNK
|. . .  .| ||||  |.  |      ..|. |... | .    . ||. ..|| ||.|. .| ||| | ||  |....
RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskve
subfamily_PP2D1_pd Subfamily PP2D1 31-78 3.2e-08 25.7 In-house 12-62 (492) alignment 
Range on Protein: 31-78
Range on HMM: 12-62/492.0
GWRNSQEDAHNSILNFDN--NTSFFAVYDGHGGAEVAQYCADKLPHFLK-N
 |. . ||..    .| |  |..||..|||. ||  |. .| .|.. |  .
rWKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevllee
Subfamily Dicty-PPM1L-like 29-72 2.5e-06 19.6 In-house 14-59 (305) alignment 
Range on Protein: 29-72
Range on HMM: 14-59/305.0
MQGWRNSQEDAHNSILNFDNN--TSFFAVYDGHGGAEVAQYCADKL
 .. |. ||| ..  .   ..   |.| |.|||.|   |.|   ||
sansrkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkkl
subfamily_ILKAP_pd Subfamily ILKAP 48-78 2.5e-06 19.8 In-house 41-71 (293) alignment 
Range on Protein: 48-78
Range on HMM: 41-71/293.0
NNTSFFAVYDGHGGAEVAQYCADKLPHFLKN
.. |..||.|||.|   ....|.|| . ...
srvsyyavfdGhaGsrasefaaeklhkkile