Gene CG12091 in Drosophila melanogaster

Synonym: Dmel\CG12091, Dmel_CG12091, CG12091

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PTC7
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP136_AA protein Get Run
DmelP136_AA_66-319 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPTC7_pd Subfamily PPTC7 74-319 7.5e-111 362.5 In-house 7-251 (252) alignment 
Range on Protein: 74-319
Range on HMM: 7-251/252.0
PGKYGEDSWFKASTASADVMGVADGVGGWRSYGIDPGEFSSFLMRTCERLVQCSHFNPQRPVNLLAYSYCELMEQKKPILGSSTACVLILNRETSTVHTA
  |.|||..| .|..||||.|||||||||||.||||.|||..||..||.|...|......||.||...|.||.|.|.|.|||||||...|.........|
rqkageDayfvsseksadvlgvADGVggWrsvGiDpsefsreLmkaceklskeskaeelkPvelleaayqelleekvpvlGssTacivvldksdkklesa

NIGDSGFVVVREGQVVHKSEEQQHYFNTPFQLSLPPPGHGPNVLSDSPESADTMSFPVRDGDVILIATDGVFDNVPEDLMLQVLSEVEgERDPVKLQMTA
|.|||||.|||.|.||..|.||||.||||.|||..|.|.. .|..|.||.||..||.|..||.|..||||.|||..|| .|..|.|.. |... .||..|
nlGDSgflvvRkgkvvfrskeqqhkfntPyQLsiapegregkvildkpeaadsksfavkkgDiivlatDGlfDNlledeileilkelk.eseksslqsla

NSLALMARTLSLNSEFLSPFALSARRNNIQARGGKPDDITVVLATV
..|| .||.|||..|. |||| .|..|...|.||||||||||.|.|
kklaekarelsldpeyespfaqkakkngleasGGKpDDitvvvavv
0049733 PP2C-like 73-318 1.5e-34 112.4 In-house 13-232 (235) alignment 
Range on Protein: 73-318
Range on HMM: 13-232/235.0
KPGKYGEDSWFKastaSADVMGVADGVGGWRSYGIDPGEFSSFLMRTCERlvqcshFNPQRPVNLLAYSYCEL--------MEQKKPILGSSTACVLILN
.  |..||...     .  ...||||.||..  ..  . . ..|.. ...      ...  ....|  .. ..        .....   . .||.|..| 
rvrkvneDavlv....glllfavaDGhgghaagevasellvetllellle......lllldleealrkaflaaneallelalaspelagmgtTavvalld

reTSTVHTANIGDSGFVVVREGQVVHKSEEQQHYFNTPFQLSLPPPGHGP--------NVLSDSPESADTMSFPVRDGDVILIATDGVFDNVPEDLMLQV
  ......||.||| ....|.|..|. .|..........|  . . |.          . | |.. ..|........||..|.|.||..|..... ....
..ggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggavrvpgrlaltralGdlllkpdvtvlelepgdflllasDGlwdvlsdeeivdl

LSEvegerdpVKLQMTANSLALMARTlslnseflspfalsarrnniqarGGKPDDITVVLAT
|..         |.. |. |. .|..                       .|..|.||||.. 
lrs.......ldleeaaerlvelala.......................rggrDNiTvvvvr
0034914 PP2C-like 75-318 9.5e-30 96.6 In-house 32-289 (295) alignment 
Range on Protein: 75-318
Range on HMM: 32-289/295.0
GKYGEDSWFKAS-----TASADVMGVADGVGGWRSYGIDPGEFSSFLMRTCERLVQCSHFNPQRPVNLLAYSYCEL--------MEQKKPILGSSTACVL
 |. ||...        . .  ..||.||.||..   .    . ..|.. .|.|.. .....  ... | ... ..        ..... . ...||.|.
rksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallrpelagsGtTavva

ILnrETSTVHTANIGDSGFVVVREGQVVHKSEEQQHYFNTPFQ-----------------------------LSLPPPGHGPNVLSDSPESAdTMSFPVR
..    .....||.||| .|..|.|..|. .... ..... ..                             . |..  . . ..|  |.   .... . 
li..rgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllslllleplvsaePdvt.vleltle

DGDVILIATDGVFDNVPEDLMLQVLSEVEGerDPVKLQMTANSLALMARTlslnseflspfalsarrnniqarGGKPDDITVVLAT
|.|..|.|.||..|..... ........        |.. |. |. .|                         .|. |.||||.. 
dddfllLasDGlwdvlsneeivdivrslla..kgldleeaaeeLvdlAla.......................rgsrDNiTvvvvr
PP2C_SIG_SM00331 67-318 9.2e-20 64.1 In-house 5-216 (217) alignment 
Range on Protein: 67-318
Range on HMM: 5-216/217.0
NLRHKYKPGKY-GEDSWFKASTAS-ADVMGVADGVGgwrsYGIDPGEFSSFLMRTCERLVQCSHFNPQRPVNLLAYSYCElmeqKKPILGSSTACVLILN
  ...|....  ..|. .  ..     .. ||||.|     |.. ...|| |    . |..  .  .| . .|  . | |    |.   .  |.......
liaqyyeeatqvsGDyydvvklnegrlllvvaDgmG....kGlaAaaassqlrtalrellsegeelsqalkrlnraiyee....keekgmfaTlllalyd

RETSTVHTANIGDSGFVVVREGQVVHKSEEqqhyfntpfqLSLPPPGHGPNVLsdspesADTMSFPVRDGDVILIATDGVFDNVPE------DLMLQVLS
 ...... ||.||| ....|.|. |.. ..           . .| |..|.|       .|. .. .  ||..|..|||..... |      .|.. . .
fssgklsyanaGdsrpyllrdgklveilkd..........vegaplGlepevs......vdirelelekgdllllytDGltearsekgfaeerleeiled

EVegerDPVKLQMTA-NSLALMARTLSLNSeflspfalsarrnniqarggkPDDITVVLAT
 |    |  . .... .   |....   |                      .||||||.  
lv....dseaqelaqkiveellelakgsng.....................eDdiTvvvvk
PPM_PTC7_SpoIIE 114-318 3.2e-15 49.6 In-house 48-228 (230) alignment 
Range on Protein: 114-318
Range on HMM: 48-228/230.0
SFLMRTCERLVQCSHFNPQR-PVNLLAYSYCEL---MEQKkPILGSSTACVLILNRETSTVHTANIGDSGFVVVRE-GQvvhkseeqqhyfntpfQLSLP
.. |..   ...   |.  . | ..|  ....|   .| . |. . .||.|.... .|.....|| ||| ...||  |.                   ..
alamgllrtalrelafaglekpeeilrrlnlalaadlede.psssgaTavvalidpstgklyvanaGdsppllvrddgg................ereri

PPGHGPNvL-SDSPESADTMSFPVRDGDVILIATDGVFdnvpedlmlqvlsEVEGErDPVKLQMT-ANSLALMART--LSLNSEFLSPFALSARRNNiQA
 .|  |  |  ..   ... ...   ||..| .||||              | | . .. ..     . |.|...     |... |. .... .  .  |
vagglps.lGilpgrvfgvlavslapGdllllytDGvv.............eaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.aa

RGGKPDDITVVLAT
.|.. ||||.. . 
eglleDDitllvvr
SpoIIE Stage II sporulation protein E (SpoIIE) 93-319 3.2e-14 45.2 Pfam-A 7-192 (193) alignment 
Range on Protein: 93-319
Range on HMM: 7-192/193.0
MGVADGVGgwrsYGIDPGEFSSFLMRTCERLVqCSHFNPQRPVNLLAYSYCELMEQKkpiLGSSTACVLILNRETSTVHTANIGDSGFVVVREGQvvhKS
..|.|.||     |..   ... |  . ..|.  .. .|.. .. |    .. .|..       ||...... .| ... ||.|.. ...||. .   . 
lvvgDvvG....hGleAalimgllrsalrela.taglepaevlerlnealarnleee...erfatavlaeydpstgkleyanaGhpppllvrpdg...gt

EEQQHYFNTPfqLSLPPPghgpnvlsdspESADTMSFPVRDGDVILIATDGVFDNVPEDLML----QVLsEVEGERDPVKlqMTANSLALMARTLSlnse
... . .. |  |.. |            . ... ..... ||..|..||||...  .|  |    . | ..  |.   .  ... . ||....|.    
kfllvstglp..lGilpe...........adyeeaelqlepgdllllyTDGvtEardpdgelfgkerll.allaeaeges..leelldalveelle....

flspfalsarrnniQARGGKPDDITVVLATV
                .|.. ||||.... |
..............lgsgeleDDitllvlrv
SpoIIE Stage II sporulation protein E (SpoIIE) 93-319 3.2e-14 45.2 In-house 7-192 (193) alignment 
Range on Protein: 93-319
Range on HMM: 7-192/193.0
MGVADGVGgwrsYGIDPGEFSSFLMRTCERLVqCSHFNPQRPVNLLAYSYCELMEQKkpiLGSSTACVLILNRETSTVHTANIGDSGFVVVREGQvvhKS
..|.|.||     |..   ... |  . ..|.  .. .|.. .. |    .. .|..       ||...... .| ... ||.|.. ...||. .   . 
lvvgDvvG....hGleAalimgllrsalrela.taglepaevlerlnealarnleee...erfatavlaeydpstgkleyanaGhpppllvrpdg...gt

EEQQHYFNTPfqLSLPPPghgpnvlsdspESADTMSFPVRDGDVILIATDGVFDNVPEDLML----QVLsEVEGERDPVKlqMTANSLALMARTLSlnse
... . .. |  |.. |            . ... ..... ||..|..||||...  .|  |    . | ..  |.   .  ... . ||....|.    
kfllvstglp..lGilpe...........adyeeaelqlepgdllllyTDGvtEardpdgelfgkerll.allaeaeges..leelldalveelle....

flspfalsarrnniQARGGKPDDITVVLATV
                .|.. ||||.... |
..............lgsgeleDDitllvlrv
PPM_PTC7_SpoIIE_motif 224-319 8.7e-10 32.2 In-house 2-80 (81) alignment 
Range on Protein: 224-319
Range on HMM: 2-80/81.0
ADTMSFPVRDGDVILIATDGVF-------DNVPEDLMLQVLSEVEGERdpvkLQMTANSLALMARTlslnseflspfalsarrnniQARGGKPDDITVVL
.|. .|..  |||.|..|||..       . ....  |..... ||..    ||  |  |   ..                     ...|.. ||||...
ydeaefqLkpgdvllLyTDGltEardsdgelfgkeellrladraegks....lqeladklvdevle....................ngsgereDDitllv

ATV
. |
lrv
PP2C_2 Protein phosphatase 2C 75-257 6.3e-09 28.4 Pfam-A 9-191 (212) alignment 
Range on Protein: 75-257
Range on HMM: 9-191/212.0
GKYGEDSWFKASTASADVMGVADGVGGWRSYGIDPGEFSSFLMRTCERLVQCSHFN-PQRPVN-LLAYSY-------CELMEQKKPILGSSTACVLILNR
||  .|...  ........ ||||.|  .   .    . . .... |.|.. . ..  .  .. ...  .       ..  .|...   ..| ...... 
gkpcqDalaireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitp

etSTVHTANIGDSGFVVVR-EGQVVHKSEEQQ-HYFNTpfQLSLPPPGHGPNVlsdspesaDTMSFPVRDGDVILIATDGVFDNVP-EDLMLQVL
   ..  ..|||.. ||.. .|.|   .|...  | |.    .|... .....        .. ......|| .|. |||| |..  |. . ..|
..geivffqiGDgaivvrdrdgevqllgepdsgeyane..ttfltsedaeeel........rirrlklepgdalllmTDGvsdslrkeepfrell
PP2C_2 Protein phosphatase 2C 75-257 6.3e-09 28.4 In-house 9-191 (212) alignment 
Range on Protein: 75-257
Range on HMM: 9-191/212.0
GKYGEDSWFKASTASADVMGVADGVGGWRSYGIDPGEFSSFLMRTCERLVQCSHFN-PQRPVN-LLAYSY-------CELMEQKKPILGSSTACVLILNR
||  .|...  ........ ||||.|  .   .    . . .... |.|.. . ..  .  .. ...  .       ..  .|...   ..| ...... 
gkpcqDalaireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitp

etSTVHTANIGDSGFVVVR-EGQVVHKSEEQQ-HYFNTpfQLSLPPPGHGPNVlsdspesaDTMSFPVRDGDVILIATDGVFDNVP-EDLMLQVL
   ..  ..|||.. ||.. .|.|   .|...  | |.    .|... .....        .. ......|| .|. |||| |..  |. . ..|
..geivffqiGDgaivvrdrdgevqllgepdsgeyane..ttfltsedaeeel........rirrlklepgdalllmTDGvsdslrkeepfrell
PPM_PTC7 129-196 2.8e-08 26.5 In-house 66-141 (259) alignment 
Range on Protein: 129-196
Range on HMM: 66-141/259.0
FNPQ-RPVNLLAYSYCE---LMEQKK------PILGSSTACVLILNRETstVHTANIGDSGFVVVREGQVVHKSEEQQ
|..   . . |  |...    .| |.      |. . ||| |.... ..  ...||.|||..|..| |..|..  |..
feeleklekalrksflaldtdeelksseantepstsGstAvvalitgsk..lyvAnvGDSravLcrsgnavkqltedH
PP2Cc_SM00332 76-196 2.7e-07 23.3 In-house 22-150 (274) alignment 
Range on Protein: 76-196
Range on HMM: 22-150/274.0
KYGEDSWFKAST----ASADVMGVADGVGGWRSYGIDPGEFSSFLMRTCERLVQCShfnPQRPVNLLAYSYCELMEQKKP---------ILGSSTACVLI
| .|| ..        ... ..||.|| || .   .   .. ..| ....   ...    . . ..|.... .. |.             |  |||.| .
ksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel...eddveealkkaflstdeeileeeqskelenalsGstavval

LNRETstVHTANIGDSGFVVVREGQVVHKSEEQQ
|..|.  .. ||.|||  |..|.|..|  |... 
lkked..lyvanvGDSravlcrngkavqlsvdhk
subfamily_Sponge-PPM-1_pd Subfamily Sponge-PPM-1 170-249 4.9e-07 19.5 In-house 109-190 (199) alignment 
Range on Protein: 170-249
Range on HMM: 109-190/199.0
VHTANIGDSG-FVVVREGQVVHKSEEQQHYFNTPFQLSLPPPGHGPNVLSDSPESADTMS-FPVRDGDVILIATDGVFDNVP
. .| .|||  ||   . . ||.   . |  .   .  |     ||.. .|.  .  ..|  ||..||..|. |||. ||  
lfvasvGdspvfvyspdtksvheatvachdkdGirtarlsGGalGpaiGtdpdlenlslsylpvaeGdivllttdGisdnfa
subfamily_CG9081_pd Subfamily CG9081 169-248 5e-07 20.1 In-house 107-188 (195) alignment 
Range on Protein: 169-248
Range on HMM: 107-188/195.0
TVHTANIGDSG-FVVVREGQVVHKSEEQQHYFNTPFQLSLPPPGHGPNVLSDSPESADTMSF-PVRDGDVILIATDGVFDNV
..  ...|||  ||  .. . |.    . |  .   .  |.    ||..  |.  .  ..|. ||..||.... .||| || 
glfvvsvGdspvfvyspdnksvrevtvashskdgirdvrlsGGalGpaiGtdpdlenlslsylpvaeGdivfltsdGvsdnf
PP2C Protein phosphatase 2C 150-195 9.7e-06 18.3 Pfam-A 96-139 (255) alignment 
Range on Protein: 150-195
Range on HMM: 96-139/255.0
KPILGSSTACVLILNRETstVHTANIGDSGFVVVREGQVVHKSEEQ
.|.   ||| | ... ..  ...||.|||  |..| .. ...  |.
epsksGstavvalirgkk..lyvAnvGDSravLcrkdnakkelted
PP2C Protein phosphatase 2C 150-195 9.7e-06 18.3 In-house 96-139 (255) alignment 
Range on Protein: 150-195
Range on HMM: 96-139/255.0
KPILGSSTACVLILNRETstVHTANIGDSGFVVVREGQVVHKSEEQ
.|.   ||| | ... ..  ...||.|||  |..| .. ...  |.
epsksGstavvalirgkk..lyvAnvGDSravLcrkdnakkelted