Synonym: CG7615, Dmel\CG7615, Dmel_CG7615, fig
Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| subfamily_PPTC7_pd | Subfamily PPTC7 | 63-309 | 1.5e-105 | 345.1 | In-house | 6-251 (252) | alignment | ||
Range on Protein: 63-309
Range on HMM: 6-251/252.0
SNQRFGEDSWFVSSTPLAEVMGVADGVGGWRDLGVDAGRFAKELMSCCSGQTQLSDFDGRSPRNMLIAGFQELSHREHPVVGSSTACLATMHRKDCTLYT
..|..|||..||||. |.|.||||||||||. |.|...|..|||..|. ... |... ..|...| |..|||.....||.||||||.......|..|..
krqkageDayfvsseksadvlgvADGVggWrsvGiDpsefsreLmkaceklskeskaeelkPvelleaayqelleekvpvlGssTacivvldksdkkles
ANLGDSGFLVVRNGRVLHRSVEQTHDFNTPYQLTVPPEDRKESYYCDKPEMAVSTRHSLLPGDLVLLATDGLFDNMPESMLLSILNGLKERGEHDLLVGA
||||||||||||.|.|..|| ||.|.|||||||...||.|......||||.|.|..... .||...|||||||||..|...|.||. |||. ...| . |
anlGDSgflvvRkgkvvfrskeqqhkfntPyQLsiapegregkvildkpeaadsksfavkkgDiivlatDGlfDNlledeileilkelkeseksslqsla
SRVVEKARELSMNASFQSPFAIKARQHNVSYSgGGKPDDITLILSSV
....|||||||......|||| ||.......| ||||||||.....|
kklaekarelsldpeyespfaqkakkngleas.GGKpDDitvvvavv
|
|||||||||
| 0049733 | PP2C-like | 66-306 | 1.2e-31 | 103.0 | In-house | 16-230 (235) | alignment | ||
Range on Protein: 66-306
Range on HMM: 16-230/235.0
RFGEDSWFVsstpLAEVMGVADGVGGWRDLGVDAGRFAKELMSCCSGqtqlsdFDGRSPRNMLIAGFQEL--------SHREHPVVGSSTACLATMHrkD
. .||...| ...||||.||.. .| .... . |.... . .. .....|.. |... .... .. .||..| .. .
kvneDavlv....glllfavaDGhgghaagevasellvetllellle......lllldleealrkaflaaneallelalaspelagmgtTavvalld..g
CTLYTANLGDSGFLVVRNGRVLHRSVEQTHDFNTPYQLTVPPEDRKESYYC--------DKPEMAVSTRHSLLPGDLVLLATDGLFDNMPESMLLSILNG
.||.||.||| ....|.|........... .....| . .... .. | . . |.. | |||..|||.|||.|..........|..
gklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggavrvpgrlaltralGdlllkpdvtvlelepgdflllasDGlwdvlsdeeivdllrs
lkergeHDLLVGASRVVEKARElsmnasfqspfaikarqhnvsysgGGKPDDITLIL
.|| |.|.|| |.. .|..|.||...
......ldleeaaerlvelala........................rggrDNiTvvv
|
|||||||||
| 0034914 | PP2C-like | 66-306 | 1.9e-29 | 95.6 | In-house | 33-287 (295) | alignment | ||
Range on Protein: 66-306
Range on HMM: 33-287/295.0
RFGEDSWFVSS-----TPLAEVMGVADGVGGWRDLGVDAGRFAKELMSCCSGQTQLSDFDGRSPRNMLIAGFQEL--------SHREHPVVGSSTACLAT
. ||...| .. ..||.||.||.. | . .. ..|.... ...|.... .....|. .|... .| . ....||..|
ksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallrpelagsGtTavval
MhrKDCTLYTANLGDSGFLVVRNGRVLHRSVEQTHDFNTPYQLTVPPEDRK-----------------------------ESYYCDKPEMAvSTRHSLLP
. .. .||.||.||| ....|||.... .|........ .. . .... | . |.. ... .| .
i..rgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllslllleplvsaePdvt.vleltled
GDLVLLATDGLFDNMPESMLLSILNGLKErGEHDLLVGASRVVEKARElsmnasfqspfaikarqhnvsysgGGKPDDITLIL
.|..|||.|||.|..... ...|.. | . . .|| . | ..|. | . .|. |.|| ..
ddfllLasDGlwdvlsneeivdivrslla.kgldleeaaeeLvdlAla........................rgsrDNiTvvv
|
|||||||||
| PP2C_SIG_SM00331 | 64-306 | 1.3e-16 | 53.8 | In-house | 13-214 (217) | alignment | |||
Range on Protein: 64-306
Range on HMM: 13-214/217.0
NQRFGEDSWFVSSTPL-AEVMGVADGVGgwrdLGVDAGRFAKELMSCCSGQTQLSdfdgRSPRNMLIAGFQELSHREHPVVGSSTACLATMHRKDCTLYT
.....|. .| ... .. ||||.| |..|. ....| . . . .. ..| . . . .... . |..|| .. .. .|.
atqvsGDyydvvklnegrlllvvaDgmG....kGlaAaaassqlrtalrellseg....eelsqalkrlnraiyeekeekgmfaTlllalydfssgklsy
ANLGDSGFLVVRngrvLHRSVEQTHDfNTPYQLTVPPEDRkesyycdkpemAVSTRHSLLPGDLVLLATDGLFDNMPES-----MLLSILNGLKerGEHD
||.||| ....| .. ||...| .....| . || . . .. .| .|||.||.||||.... | | || | ....
anaGdsrpyllr....dgklveilkd.vegaplGlepevs...........vdirelelekgdllllytDGltearsekgfaeerleeiledlv..dsea
LLVGAsRVVEKARELSMNA-SfqspfaikarqhnvsysgggkPDDITLIL
... . ||.. ||. .. .||||...
qelaq.kiveellelakgsng.....................eDdiTvvv
|
|||||||||
| PPM_PTC7_SpoIIE | 82-245 | 9.3e-16 | 51.3 | In-house | 34-173 (230) | alignment | |||
Range on Protein: 82-245
Range on HMM: 34-173/230.0
VMGVADGVGgwrdLGVDAGRFAKELMSCCSGQTqLSDFDgrSPRNMLIAGFQELSHREHPV--VGSSTACLATMHRKDCTLYTANLGDSGFLVVRNGRVl
. |.|..| |..| ....| .. . ... | . |......|.... .. .||..| . . .||.||.||| .|.||...
alvvgdvdG....hGgraalamgllrtalrela.fagle..kpeeilrrlnlalaadledepsssgaTavvalidpstgklyvanaGdsppllvrddgg.
hrSVEQTHDFNTPYqLTV-PPEDRKEsyycdkpemavsTRHSLLPGDLVLLATDGLFDNMPEsmllS
.|.. .. |. | . | . .. .. || |||| ||.|||. .. |. .
..ererivagglps.lGilpgrvfgv............lavslapGdllllytDGvveaepd....t
|
|||||||||
| SpoIIE | Stage II sporulation protein E (SpoIIE) | 83-308 | 5e-14 | 44.6 | Pfam-A | 7-191 (193) | alignment | ||
Range on Protein: 83-308
Range on HMM: 7-191/193.0
MGVADGVGgwrdLGVDAGRFAKELMSCCSGQTqLSDFDgrsPRNMLIAGFQEL-SHREHPvVGSSTACLATMHRKDCTLYTANLGDSGFLVVRNGRvlhR
..|.|.|| |..| .. .| | .. . | ..| . . | .. |. . ||.|| .. .. .|. ||.|.. .|.||. . .
lvvgDvvG....hGleAalimgllrsalrela.tagle...paevlerlnealarnleee.erfatavlaeydpstgkleyanaGhpppllvrpdg...g
SVEQTHDFNTPyqLTVPPEdrkesyycdkpEMAVSTRHSLLPGDLVLLATDGLFDNMPESMLL----SILNGLKERGEHDLLVGASRVVEKARElsmnas
........ | | . || . . ... | ||||.||.|||..... . | |. |.|. ...| ....||...|
tkfllvstglp..lGilpe...........adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveelle......
fqspfaikarqhnvsYSGGGKPDDITLILSS
..|.. |||||..
...............lgsgeleDDitllvlr
|
|||||||||
| SpoIIE | Stage II sporulation protein E (SpoIIE) | 83-308 | 5e-14 | 44.6 | In-house | 7-191 (193) | alignment | ||
Range on Protein: 83-308
Range on HMM: 7-191/193.0
MGVADGVGgwrdLGVDAGRFAKELMSCCSGQTqLSDFDgrsPRNMLIAGFQEL-SHREHPvVGSSTACLATMHRKDCTLYTANLGDSGFLVVRNGRvlhR
..|.|.|| |..| .. .| | .. . | ..| . . | .. |. . ||.|| .. .. .|. ||.|.. .|.||. . .
lvvgDvvG....hGleAalimgllrsalrela.tagle...paevlerlnealarnleee.erfatavlaeydpstgkleyanaGhpppllvrpdg...g
SVEQTHDFNTPyqLTVPPEdrkesyycdkpEMAVSTRHSLLPGDLVLLATDGLFDNMPESMLL----SILNGLKERGEHDLLVGASRVVEKARElsmnas
........ | | . || . . ... | ||||.||.|||..... . | |. |.|. ...| ....||...|
tkfllvstglp..lGilpe...........adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveelle......
fqspfaikarqhnvsYSGGGKPDDITLILSS
..|.. |||||..
...............lgsgeleDDitllvlr
|
|||||||||
| PPM_PTC7_SpoIIE_motif | 217-309 | 4.8e-09 | 29.8 | In-house | 5-80 (81) | alignment | |||
Range on Protein: 217-309
Range on HMM: 5-80/81.0
TRHSLLPGDLVLLATDGLFDNMPESMLL----SILNGLKERGEHDLLVGASRVVEKARElsmnasfqspfaikarqhnvsYSGGGKPDDITLILSSV
.. | |||..||.||||.... . | | .... ...| | ..|....| ...|.. |||||.. |
aefqLkpgdvllLyTDGltEardsdgelfgkeellrladraegkslqeladklvdevle.....................ngsgereDDitllvlrv
|
|||||||||
| PP2C_2 | Protein phosphatase 2C | 62-241 | 9.6e-09 | 27.8 | Pfam-A | 6-184 (212) | alignment | ||
Range on Protein: 62-241
Range on HMM: 6-184/212.0
RSNQRFGEDSWFVSSTPLAEVMGVADGVGGWRDLGVDAGRFAKELMSCCSGQTQLSDFD-GRSPRNMLIAGFQE-------LSHREHPVVGSSTACLATM
|... . .|....... .... ||||.| . . | ... .... . . . .... . .. . .. .. . ..... .|..|...
rrkgkpcqDalaireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllav
hRKDCTLYTANLGDSGFLVV-RNGRVLHRSVEQTHDFNtPYQLTVPPEDRKESYycdkpemavST-RHSLLPGDLVLLATDGLFDNMPES
... ... ...||.. .|. |.|.| . ...... ...|| |.. . | | ||| .|| |||. |.. ..
.itpgeivffqiGDgaivvrdrdgevqllgepdsgeya.nettfltsedaeeel.........rirrlklepgdalllmTDGvsdslrke
|
|||||||||
| PP2C_2 | Protein phosphatase 2C | 62-241 | 9.6e-09 | 27.8 | In-house | 6-184 (212) | alignment | ||
Range on Protein: 62-241
Range on HMM: 6-184/212.0
RSNQRFGEDSWFVSSTPLAEVMGVADGVGGWRDLGVDAGRFAKELMSCCSGQTQLSDFD-GRSPRNMLIAGFQE-------LSHREHPVVGSSTACLATM
|... . .|....... .... ||||.| . . | ... .... . . . .... . .. . .. .. . ..... .|..|...
rrkgkpcqDalaireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllav
hRKDCTLYTANLGDSGFLVV-RNGRVLHRSVEQTHDFNtPYQLTVPPEDRKESYycdkpemavST-RHSLLPGDLVLLATDGLFDNMPES
... ... ...||.. .|. |.|.| . ...... ...|| |.. . | | ||| .|| |||. |.. ..
.itpgeivffqiGDgaivvrdrdgevqllgepdsgeya.nettfltsedaeeel.........rirrlklepgdalllmTDGvsdslrke
|
|||||||||
| PPM_PTC7 | 97-188 | 2.7e-08 | 26.6 | In-house | 46-142 (259) | alignment | |||
Range on Protein: 97-188
Range on HMM: 46-142/259.0
VDAGRFAKELMS-CCSGQTQLSDFDgrSPRNMLIAGFQELS----HR------EHPVVGSSTACLATMHRKdctLYTANLGDSGFLVVRNGRVLhRSVEQ
|...|.| . . . .. ... . . |. .|..|. .. |. .||. ... . | ||.||.|||.....|.|.. . .
reaakyarehleeilkerksfeele..klekalrksflaldtdeelksseantepstsGstAvvalitgsk...lyvAnvGDSravLcrsgnav.kqlte
THD
.|.
dHk
|
|||||||||
| PP2Cc_SM00332 | 67-187 | 4.7e-08 | 25.7 | In-house | 23-151 (274) | alignment | |||
Range on Protein: 67-187
Range on HMM: 23-151/274.0
FGEDSWFVSST----PLAEVMGVADGvggwrDLGVDAGRFAKELMSCCSGQTQLSDFD--GRSPRNMLIAGFQELSHREHPVVG-------SSTACLATM
.|| ..| . ..||.|| | .. .|... . .. .. .. | .. . | .|... . .| ... ..
smeDahvvvvdlveeedwlffgvfDG.....hgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelenalsGstavva
HRKDCTLYTANLGDSGFLVVRNGRVLHRSVEQTH
. |. .|| ||.||| ..||| .. ||...
llkkedlyvanvGDSravlcrngkavqlsvdhkp
|
|||||||||
| PP2Cc_SM00332 | 203-305 | 3e-06 | 19.8 | In-house | 194-272 (274) | alignment | |||
Range on Protein: 203-305
Range on HMM: 194-272/274.0
KESYYCDKPEMAVSTRhsLLPGDLVLLATDGLFDNMPESMLLSILNGLKERGehdllvgASRVVEKARELSMNASFQSpfaikarqhnvsysgGGKPDDI
|| | .|.. | | .....||.|||.|.. . . .|.. |...| . ...| || ... .. ||. |.|
kepyitaepdvkvvtl..tsedeflilaSDGlwdvlsnqevvdivrkllakg.......ktndpqeaaelldeeairr...............ggseDni
TLI
| .
Tvv
|
|||||||||
| PP2C | Protein phosphatase 2C | 123-188 | 4.8e-06 | 19.3 | Pfam-A | 71-141 (255) | alignment | ||
Range on Protein: 123-188
Range on HMM: 71-141/255.0
SPRNMLIAGFQE------LSHR---EHPVVGSSTACLATMHRKdctLYTANLGDSGFLVVRNGRVLhRSVEQTHD
.. |. .|.. |.. |. .||. . . | ||.||.||| ...|... .. ..|.
kvekalrksfladtdeelksskantepsksGstavvalirgkk...lyvAnvGDSravLcrkdnak.keltedHk
|
|||||||||
| PP2C | Protein phosphatase 2C | 123-188 | 4.8e-06 | 19.3 | In-house | 71-141 (255) | alignment | ||
Range on Protein: 123-188
Range on HMM: 71-141/255.0
SPRNMLIAGFQE------LSHR---EHPVVGSSTACLATMHRKdctLYTANLGDSGFLVVRNGRVLhRSVEQTHD
.. |. .|.. |.. |. .||. . . | ||.||.||| ...|... .. ..|.
kvekalrksfladtdeelksskantepsksGstavvalirgkk...lyvAnvGDSravLcrkdnak.keltedHk
|
|||||||||