Gene ALPI in Homo sapiens

Synonym: IAP, ALPI

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold AP
Superfamily AP
Family AP
Subfamily AP
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP001_AA protein Get Run
HsapP001_AA_21-493 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_AP_pd Subfamily AP 27-491 7e-202 661.9 In-house 2-470 (472) alignment 
Range on Protein: 27-491
Range on HMM: 2-470/472.0
NPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANF
...||...|.|.|..| .||. .| |||.|||||||.|| ||||.||||||..|.|| |. ||...|||..|||||..|.|||||||||||||||||.|.
sakfwlkkaqeelkealelqsnskkakNvilflgdGmgvstvtaaRilkgqlkgelgeeasLaleeFpyvglsktyssdkqvpdsaatAtAylcGvktnn

QTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLI---SNMDIDVILGGGR
.|||..||.....|....|.|| |....||.|||..|.||||||.||||||.|||. ||||.||...||.|..|||.|||.|||   .....||||||||
gtiGvdaaverkdCeasagkevdsileaAkkaGkatGlVtttrvthAsPaglyahvanRnwesdeevpaeaekegckdiaqQLieeevgkeldvilGGGr

KYMFPMGTPDPEYPADasqnGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDqSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPR
|...|....|.||. .    | | ||.||..|| .....| ||.||.||.... . ....|.|||.... ||||.||.. .|||.||||.||..||.|..
kkflpktvkdseyekk....gerkDgrnLieewekekknakyvenrkelenvdks.ktdrllGlfadshlkyeidrdekeePsLkemtekAlevLsknen

GFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAP-SKAQDSKAYTSILYGNGPGYVFNS
||.||||||||||.|||. |..||.|...||.|.|.| .||.|||||..|||||||.... ||. |||||.|||. ||..|...|| ..| |||||. ..
GffLfVEggrIDhahhenkakkaleetlefdeavelaleltdeedTlivvtaDHshtltiagypkrgssilglakesksadelpyttlsyangpgyelte

-----GVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYT
     | | |..|.|....||..||||||..||||||||||.|.|||.||..||.|||..|||||.||||....
sdleegerkdlteaeteakdyvsqaavpleeetHggeDvavyasGpqshlltGvveqstiahvmayaaclgeae
Alk_phosphatase Alkaline phosphatase 52-487 8.4e-188 615.1 Pfam-A 1-421 (421) alignment 
Range on Protein: 52-487
Range on HMM: 1-421/421.0
AKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETpLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSaaarfnqcntTRGNEVISV
|||.||..|||.||.||||.|.||.|..||||.|. ||.||.|...|||||.||.||.|||||||||.||||.. ..||..          |.|.|| ||
aknvilligDGmgvstvtaaRslkeqakgklgeei.laldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd..........thgkevksv

MNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNM-DIDVILGGGRKYMFPMGTPDPeypadASQNGIRLDGK
...||.||||.|.||||||.||.||...||...|.|..||...|||..||..|||.|||... .|||.||||||...|.||.|.     ....|.||||.
leaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaataasakkeGkkdiaeqlikakkkidvllGGGrkeflptgtkde.....ekerGtrldgr

NLVQEWlaKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEA
||..|.  |..|. ||..|.||..|. ..||..|.|||..||.|.|..||.. .|||.||||.|..|||.|..||.|.|||.||||..||. |..||.|.
nlieea..kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkvelerdekeePsLkemtevAiklLsknekGFFLlVEGsrIDhaaHendavgalsEv

VMFDDAIERAGQLT-SEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKA-QDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSS
|.||.|...| ... .|..||..||||||||||.|||| ||.||.|||..|. .| ||...||||||.|.  . |.|..|...|...  |....||.|.|
vefdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaakktkdgkakklilygngegakvedgarenvtaeealekiyrkrsavglts

ETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACL
|.|.||||||||.||.|.||.|||||  .|.|.|.|..|
eeHtgedvavfAygpkaelvrGvqeqteiakvlaaalel
Alk_phosphatase Alkaline phosphatase 52-487 8.4e-188 615.1 In-house 1-421 (421) alignment 
Range on Protein: 52-487
Range on HMM: 1-421/421.0
AKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETpLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSaaarfnqcntTRGNEVISV
|||.||..|||.||.||||.|.||.|..||||.|. ||.||.|...|||||.||.||.|||||||||.||||.. ..||..          |.|.|| ||
aknvilligDGmgvstvtaaRslkeqakgklgeei.laldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd..........thgkevksv

MNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNM-DIDVILGGGRKYMFPMGTPDPeypadASQNGIRLDGK
...||.||||.|.||||||.||.||...||...|.|..||...|||..||..|||.|||... .|||.||||||...|.||.|.     ....|.||||.
leaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaataasakkeGkkdiaeqlikakkkidvllGGGrkeflptgtkde.....ekerGtrldgr

NLVQEWlaKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEA
||..|.  |..|. ||..|.||..|. ..||..|.|||..||.|.|..||.. .|||.||||.|..|||.|..||.|.|||.||||..||. |..||.|.
nlieea..kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkvelerdekeePsLkemtevAiklLsknekGFFLlVEGsrIDhaaHendavgalsEv

VMFDDAIERAGQLT-SEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKA-QDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSS
|.||.|...| ... .|..||..||||||||||.|||| ||.||.|||..|. .| ||...||||||.|.  . |.|..|...|...  |....||.|.|
vefdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaakktkdgkakklilygngegakvedgarenvtaeealekiyrkrsavglts

ETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACL
|.|.||||||||.||.|.||.|||||  .|.|.|.|..|
eeHtgedvavfAygpkaelvrGvqeqteiakvlaaalel
0037220 Alkaline phosphatase-like 22-493 9.8e-178 581.7 In-house 3-474 (479) alignment 
Range on Protein: 22-493
Range on HMM: 3-474/479.0
PAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCG
. ..... .....| ..| .|..|.. ...|||.|||.|||.||.||||.||..|| .|.|| |..||.|.||...|.|||.||..|.||||.|||...|
lllllllllllllalallllalllllnkskaknvilfigDGmgvstvtaariylgqllgglgeegllaldkfplvglvkTysvdslvtDSAaaaTAlatG

VKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGG
||.|. .||..|......|....||.| ... .||.|||..|.|||||..||.||..|||..||||..|..... . ..||.||||||. ....||||||
vKtnngaigvdadvsrdncddplgnpvetilelakeaGkatGlVtTtrithATPAafyAhvanRnweddialqllgleagckdiatqlvlgsgldvilGG

GRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRN
||||..| ||.||||. .  ..| ||||..|..|. .|..|. ||.||.||....|...|..|.|||.... .||..||.. .||| ||||.||.|||.|
GrkyflpkgtldpeydlelllggkrldgrdlleeakekkkgytyvtnreeldaldlgsnvdkllGlfadshlpyeldrdaseePsLaemtekAldlLskn

PRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFN
..||.|.||||||||..|.. |. ||.|...||.|.|.| ......|||..|||||||.....||. ||..|.||.|....| ..|| .||.||||....
dkGFfLmvEggriDhagHandaaaalgevlafdeaveaalefakdddTlvvvtADHshgglilgyadrgnpilgllpgllldglpyttllyangpgflll

SGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTAC
 ..|.|..     .....|.|.|...|..|.||||.|.|.||.|.|..||.|....|||.|.|..|.... .
ldlrldltllvtlallllqralvgwtsggHtgedVpvyayGpgaelflgvyentdiahviasalglgllevl