Gene ALPP in Homo sapiens

Synonym: ALP, PALP, PLAP, PLAP-1, ALPP

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold AP
Superfamily AP
Family AP
Subfamily AP
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP003_AA protein Get Run
HsapP003_AA_38-511 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_AP_pd Subfamily AP 45-509 7.8e-204 668.3 In-house 2-470 (472) alignment 
Range on Protein: 45-509
Range on HMM: 2-470/472.0
NPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNF
...||...|.|.| .| .||.... |||.|.||||||||||||||||||||.|..|| |  ||...||||.|||||..||.|||| ||||||||||| |.
sakfwlkkaqeelkealelqsnskkakNvilflgdGmgvstvtaaRilkgqlkgelgeeasLaleeFpyvglsktyssdkqvpdsaatAtAylcGvktnn

QTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLI---SNMDIDVILGGGR
.|||..||.....|....|.|| |....||||||..|.||||||.||||||.|||. ||||.||..|||.|..|||.|||.|||   .....||||||||
gtiGvdaaverkdCeasagkevdsileaAkkaGkatGlVtttrvthAsPaglyahvanRnwesdeevpaeaekegckdiaqQLieeevgkeldvilGGGr

KYMFRMGTPDPEYPDDysqgGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDpSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPR
|... ....|.||...    |.| ||.||..|| .....|.||.||.||.... . ....|.|||.....||||.||.. .|||.||||.||..||.|..
kkflpktvkdseyekk....gerkDgrnLieewekekknakyvenrkelenvdks.ktdrllGlfadshlkyeidrdekeePsLkemtekAlevLsknen

GFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAP-GKARDRKAYTVLLYGNGPGYVLKD
|||||||||||||.|||..|..||.||..||.|.|.| .||.||||| .|||||||.... ||| |||||.|||.  |..|...||.|.| |||||.|..
GffLfVEggrIDhahhenkakkaleetlefdeavelaleltdeedTlivvtaDHshtltiagypkrgssilglakesksadelpyttlsyangpgyelte

-----GARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYT
     |.| |.||.|.....|..|.||||.||||.||||||.|.|||.||..||.||..||||||.||||....
sdleegerkdlteaeteakdyvsqaavpleeetHggeDvavyasGpqshlltGvveqstiahvmayaaclgeae
Alk_phosphatase Alkaline phosphatase 70-505 1.9e-191 627.1 Pfam-A 1-421 (421) alignment 
Range on Protein: 70-505
Range on HMM: 1-421/421.0
AKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIpLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSaaarfnqcntTRGNEVISV
|||.|...|||||||||||||.||.|.|.|||.|| ||.||.|.|.|||||.|||.|.||.||||||.|||| . ..||..          |.|.|| ||
aknvilligDGmgvstvtaaRslkeqakgklgeei.laldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd..........thgkevksv

MNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNM-DIDVILGGGRKYMFRMGTPDPeypddYSQGGTRLDGK
...|||||||.|.||||||.||.||...||...|.|..||...|||..||..|||.|||... .|||.||||||.....||.|.     ... ||||||.
leaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaataasakkeGkkdiaeqlikakkkidvllGGGrkeflptgtkde.....ekerGtrldgr

NLVQEWlaKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTET
||..|.  |..|..||..|.||..|. ..||..|.|||..||.|.|..||.. .|||.||||.|..|||.|..||||.|||.||||..||..|..||.|.
nlieea..kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkvelerdekeePsLkemtevAiklLsknekGFFLlVEGsrIDhaaHendavgalsEv

IMFDDAIERAGQLT-SEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKA-RDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDE
..||.|...| ... .|..|| .||||||||||.|||. ||.||.|||. |. .|.||....|||||.|. ..||||..||..|... .||..|||.|..
vefdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaakktkdgkakklilygngegakvedgarenvtaeealekiyrkrsavglts

ETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACL
|.|.||||||||.||.|.||.|||||| ||.|.|.|..|
eeHtgedvavfAygpkaelvrGvqeqteiakvlaaalel
Alk_phosphatase Alkaline phosphatase 70-505 1.9e-191 627.1 In-house 1-421 (421) alignment 
Range on Protein: 70-505
Range on HMM: 1-421/421.0
AKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIpLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSaaarfnqcntTRGNEVISV
|||.|...|||||||||||||.||.|.|.|||.|| ||.||.|.|.|||||.|||.|.||.||||||.|||| . ..||..          |.|.|| ||
aknvilligDGmgvstvtaaRslkeqakgklgeei.laldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd..........thgkevksv

MNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNM-DIDVILGGGRKYMFRMGTPDPeypddYSQGGTRLDGK
...|||||||.|.||||||.||.||...||...|.|..||...|||..||..|||.|||... .|||.||||||.....||.|.     ... ||||||.
leaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaataasakkeGkkdiaeqlikakkkidvllGGGrkeflptgtkde.....ekerGtrldgr

NLVQEWlaKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTET
||..|.  |..|..||..|.||..|. ..||..|.|||..||.|.|..||.. .|||.||||.|..|||.|..||||.|||.||||..||..|..||.|.
nlieea..kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkvelerdekeePsLkemtevAiklLsknekGFFLlVEGsrIDhaaHendavgalsEv

IMFDDAIERAGQLT-SEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKA-RDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDE
..||.|...| ... .|..|| .||||||||||.|||. ||.||.|||. |. .|.||....|||||.|. ..||||..||..|... .||..|||.|..
vefdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaakktkdgkakklilygngegakvedgarenvtaeealekiyrkrsavglts

ETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACL
|.|.||||||||.||.|.||.|||||| ||.|.|.|..|
eeHtgedvavfAygpkaelvrGvqeqteiakvlaaalel
0037220 Alkaline phosphatase-like 39-511 1.1e-175 574.9 In-house 2-474 (479) alignment 
Range on Protein: 39-511
Range on HMM: 2-474/479.0
IPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLC
........ .... | ..| .|..|.. .. |||.|.|.||||||||||||||..|| ...|| | .||.|.||.|.|.|||.||. |.|| |.|||...
llllllllllllllalallllalllllnkskaknvilfigDGmgvstvtaariylgqllgglgeegllaldkfplvglvkTysvdslvtDSAaaaTAlat

GVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILG
||| |. .||..|......|....||.| ... .||.|||..|.|||||..||.||..|||..||||..|..... . ..||.||||||. ....|||||
GvKtnngaigvdadvsrdncddplgnpvetilelakeaGkatGlVtTtrithATPAafyAhvanRnweddialqllgleagckdiatqlvlgsgldvilG

GGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSR
|||||... ||.||||.... .||.||||..|..|. .|..|..||.||.||....|...|..|.|||......||..|| . .||| ||||.||.|||.
GGrkyflpkgtldpeydlelllggkrldgrdlleeakekkkgytyvtnreeldaldlgsnvdkllGlfadshlpyeldrdaseePsLaemtekAldlLsk

NPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVL
|..||||.||||||||..|.  |..||.|...||.|.|.| ......||| .|||||||.....||. ||..|.||.||.. | ..|| |||.||||..|
ndkGFfLmvEggriDhagHandaaaalgevlafdeaveaalefakdddTlvvvtADHshgglilgyadrgnpilgllpgllldglpyttllyangpgfll

KDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTAC
  . |.|.|     .. ..|...|... ..| ||||.|.|.||.|.|..||.|.|.||||.|.|..|.... .
lldlrldltllvtlallllqralvgwtsggHtgedVpvyayGpgaelflgvyentdiahviasalglgllevl