Gene LMWPTP in Homo sapiens

Synonym: HAAP, ACP1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC2
Superfamily CC2
Family LMWPTP
Subfamily LMWPTP
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP112_AA protein Get Run
HsapP112_AA_5-156 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_LMWPTP_pd Subfamily LMWPTP 7-156 5e-75 240.4 In-house 2-151 (152) alignment 
Range on Protein: 7-156
Range on HMM: 2-151/152.0
KSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQ
|.||||||||||||||||||.||||......|.|.|||||.| |..|. || |..|..|.||. .||.|||||||||..|||||.||||||..|.. ...
kkvlfvClGniCrspiaEavlrklvekkglkedwkvdsaaissyhvGkepdkRalsilkkhglksshrarqitkedfsefdyilamDesnlkelkklake

VKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEK
 |..|||..|||.|| ... ||||||||...|||.||.|...||.|||.|
kkeskakvlllgeydkkgkeiiedpyygdekdFeavykqikecckaflkk
0053360 Phosphotyrosine protein phosphatases I 6-156 6.7e-54 172.2 In-house 5-155 (157) alignment 
Range on Protein: 6-156
Range on HMM: 5-155/157.0
TKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSN
.|.|||||.|||||||.|||..|.|...........|||| ||....|.|.| | .......||..||.|||.|.||. .||.||.||.|||..| .  .
mkkvLfvCtgNicRSpmAeallrhlleeaglgdrfevdSaGtsalhvggpvdpravevlaelgidlshrarqlteedleefdliltmddsnleellplfp

QVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEK
..  .|.|. ||......  . ..|||||....||.|.........|.||.
glleakgkvllllefagllhwdvpDPyyggleafelvldlieeaveallel
0048765 Phosphotyrosine protein phosphatases I 6-156 1.5e-53 171.0 In-house 2-152 (154) alignment 
Range on Protein: 6-156
Range on HMM: 2-152/154.0
TKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSN
.|.|||||.|||||||.|||..|.|...........|||| ||.| .|.|.| | .......||..||.|||.|.||. .||.||.||.|||..| .   
mkkvLfvCtgNicRSpmAeallrhlleeaglgdrvevdSaGtsayhvgepvdpravevlaelgidlshrarqlteedleefdliltmddsnleellplfp

QVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEK
..  .|.|. ||......  . ..|||||....||.|.........|.||.
glleakgkvllllefagllhwdvpDPyyggleafeevldlieeaveallel
0046251 Phosphotyrosine protein phosphatases I 6-156 2.3e-53 170.7 In-house 5-157 (159) alignment 
Range on Protein: 6-156
Range on HMM: 5-157/159.0
TKSVLFVCLGNICRSPIAEAVFRKLVTDQNISEN-WRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKS
.|.|||||.|||||||.|||..|.|. |...|.. ..||||.||....|.||| | ....|..||..||.|||.|.||| .||.||.||.|||||| |  
kkkvlfvCtgNicRSpmAeallrhlledaglsdllievdSaGtsalhvgeppdpravavlkelgidlshrarqlteedfeefdlilamddsnlrdllrla

NQvkTCKAKIELLGSYDPQKQ---LIIEDPYYGNDSDFETVYQQCVRCCRAFLEK
 .   ...|. ||...... .   . ..|||||....||.|.........|.|||
pg..dargkvllllefagllellhwdvpDPyyggleaFeevldlieeaveallek
LMWPc Low molecular weight phosphotyrosine protein phosphatase 9-154 1e-49 159.0 Pfam-A 1-138 (138) alignment 
Range on Protein: 9-154
Range on HMM: 1-138/138.0
VLFVCLGNICRSPIAEAVFRKLVTDQnISENWRVDSAATSGYeIGNPPDYRGQSCMKRHGIPMS-HVARQITKEDFATFDYILCMDESNLRDLNRKSNQv
|||||.|||||||.|||..|.|.... ......||||.|... .|...| | ....|..||..| |.|||...|....||.||..||...|.|.. . . 
vlfvCtgNicRSpmAeallralleka.lgdkvevdSAGteal.vgesvdpravevlkekgidisghrarqlseeelkefDliltldeeaarelcpvape.

kTCKAKIELLGSydpqkQLIIEDPYYGNDSDFETVYQQCVRCCRAFL
 ...||. |||.     |. |.|||......||.|.... ......|
.kkeakvvllge.....qwdipDPygkeeeefeevrdeieervkkll
LMWPc Low molecular weight phosphotyrosine protein phosphatase 9-154 1e-49 159.0 In-house 1-138 (138) alignment 
Range on Protein: 9-154
Range on HMM: 1-138/138.0
VLFVCLGNICRSPIAEAVFRKLVTDQnISENWRVDSAATSGYeIGNPPDYRGQSCMKRHGIPMS-HVARQITKEDFATFDYILCMDESNLRDLNRKSNQv
|||||.|||||||.|||..|.|.... ......||||.|... .|...| | ....|..||..| |.|||...|....||.||..||...|.|.. . . 
vlfvCtgNicRSpmAeallralleka.lgdkvevdSAGteal.vgesvdpravevlkekgidisghrarqlseeelkefDliltldeeaarelcpvape.

kTCKAKIELLGSydpqkQLIIEDPYYGNDSDFETVYQQCVRCCRAFL
 ...||. |||.     |. |.|||......||.|.... ......|
.kkeakvvllge.....qwdipDPygkeeeefeevrdeieervkkll
0042188 Phosphotyrosine protein phosphatases I 6-156 9.7e-46 145.6 In-house 4-142 (146) alignment 
Range on Protein: 6-156
Range on HMM: 4-142/146.0
TKSVLFVCLGNICRSPIAEAVFRKLVtdqniSENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMS-HVARQITKEDFATFDYILCMDESNLRDLNRKS
.|.|||||.|||||||.|||..|.|.     .. ..|||| ||.| .|.|.| | .......||..| |.|||.|.||. .||..|.||.|||||| .  
kkkvlfvCtgNicRSpmAeallrhll.....gdrvevdSAGtsayhvgepvdpravevlaelgidisghrarqlteedleefDlvltmddsnlrdllplf

NqvKTCKAKIELLGSYDpqkqlIIEDPYYGNdSDFETVYQQCVRCCRAFLEK
   ...|.|. ||...       ..|||||. ..||.|.... ....|.||.
p..gaakgkvllllefw.....dvpDPyygg.eafeevldlieeavkallel
LMWPc_SSU72_ArsC 7-146 1.6e-42 135.4 In-house 1-126 (126) alignment 
Range on Protein: 7-146
Range on HMM: 1-126/126.0
KSVLFVCLGNICRSPIAEAVFRKLVTDqniseNWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQ
|.|||||||||||||.||||..|.|..     ...|.||.|. .. |...| | ....|..||...| .||...||. .||.||.|||.| ... .. ..
kkvlfvClgNicRSpmAeavlkkavkk.....glnvsSaGtgaavpgksidsravellkengielkhkprqlqeedlkefdliltmdernkdevlellpe

VktCKAKIELLgsydpqkQLIIEDPYYGNDSDFETVYQQC
   ...|..||       .| ..|||.|. |.|| |....
r..atkkvhll.......nldvkDpyegaesgfeevldli
0051181 Phosphotyrosine protein phosphatases I 8-155 7.9e-39 122.7 In-house 1-123 (124) alignment 
Range on Protein: 8-155
Range on HMM: 1-123/124.0
SVLFVCLGNICRSPIAEAVFRKLVTDqnisenWRVDSAATsgyEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNqv
.|||||.|||||||.|||..|.|. |      ..|||| |   ..|.|.| | . .....||..|....|....|. .||..|.||.|||..| .     
kvlfvCtgNicRSpmAeallrhllgd......vevdSAGt...hpggpvdpravevlaelgidlslrskqldeldleefdlvltmddsnlcpllplap..

ktckakiellgsydPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLE
                  . ..|||||....||.|.... ....|.||
..............lllhwdvpDPyyggleefeevldlieervealle
0047618 Phosphotyrosine protein phosphatases I 7-155 2.2e-37 118.2 In-house 2-134 (137) alignment 
Range on Protein: 7-155
Range on HMM: 2-134/137.0
KSVLFVCLGNICRSPIAEAVFRKLVTDQnisenWRVDSAATSGYEignpPDYRGQSCMKRHGIPMS-HVARQITKEDFATFDYILCMDESNLRDLNRKSN
|.|||||.|||||||.|||..|.|. |.     ..|||| |....    .| | . .....||..| |...|....|. .||..|.||.|.|..| .  .
kkvlfvCtgNicRSpmAeallrhllgdr.....vevdSAGtepag....vdpravevlaelgidisghrskqldeldlpefdlvltmddsalealpllap

QVKTCKAkiellgsydpqkqlIIEDPYYGN------DSDFETVYQQCVRCCRAFLE
.... .                ..|||||.        .||.|.... ....|.||
aalrlhw..............dvpDPyygggteeekleafervldlieervealle
LMWPc_SSU72 8-155 3e-36 115.3 In-house 2-136 (137) alignment 
Range on Protein: 8-155
Range on HMM: 2-136/137.0
SVLFVCLGNICRSPIAEAVFRKLVTdqniseNWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQV
.|||||..||.||..|||.... ..      ...|.|| |. . .|. .| . ....|..|. ..........|....||......|......... .. 
kvlfVCasNinRSmeAeallkeale......glevkSaGtgslvpgpsidkpaeelykenGlsikeapeklqeeelekfDlvitleervfdavvedlper

KTCKAKIELLgsydpqkQLIIEDPYYGNDSDFETVYQQCVRCCRAFLE
...|.|. ..       .. |.||.... ..|....... ......|.
selkrkvhvi.......nvdikDpheeaiegfkaildlieervkella
0047572 Phosphotyrosine protein phosphatases I 7-155 6.9e-35 110.0 In-house 3-129 (130) alignment 
Range on Protein: 7-155
Range on HMM: 3-129/130.0
KSVLFVCLGNICRSPIAEAVFRKLVtdqniSENWRVDSAATSgyeiGNPPDYRGQSCMKRHGIPM-SHVARQITKEDFATFDYILCMDESNLRDLNRKSN
|.|||||.||.||||.|||..|.|.     .....|.|| |.    |...| | . .....||.. .|...|...... .||....||.|.|..| .  .
kkvlfvCtgNscRSpmAeallrhll.....gdrvevySAGte....gsgvdpravevlaelgidisghrskqldelllpefdlvitmddsalealpllap

QVKTCKAkiellgsydpqkqlIIEDPYYGNDSDFETVYQQCVRCCRAFLE
.....                 |.|||.|....|..|.... |...|.||
aalrlhw..............dipDPygggleafrevrdlierrvlalle
subfamily_Sponge-LMWPTP-like_pd Subfamily Sponge-LMWPTP-like 9-46 1.6e-06 17.8 In-house 3-38 (173) alignment 
Range on Protein: 9-46
Range on HMM: 3-38/173.0
VLFVCLGNICRSPIAEAVFRKLVTDQNisENWRVDSAA
.|||| || ||||.|  |  |. ....       ||||
llfvcsgnscrspmamivaekmeaere..kiiesdsaa