Gene PPP3CA in Homo sapiens

Synonym: CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B, PPP3CA

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP3C
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP138_AA protein Get Run
HsapP138_AA_82-285 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP3C_pd Subfamily PPP3C 16-485 1.5e-260 857.5 In-house 1-452 (452) alignment 
Range on Protein: 16-485
Range on HMM: 1-452/452.0
RVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLF
||||.||.|.|..||..||||..|||....|| |..|||||||..||.||.|.|..|..||.||...||.||.|||||||.||.|||||||.||.|.|||
rvvkkvplpkskklteeevfdetgkpklevlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylf

LGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKL
||||||||||||||||||.|||| ||.|||||||||||||||||||||.||||||||.||||||..||.||||||.|||||||||||||||..||||.||
lGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkl

DRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVY
||||||||.||.||.||||||||.|.|||.|.|..|.|||||||||| |||||||.|.||||.||||||||||||||||..||||||||.||||||||||
drfkeppasGplcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvy

NNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELGSEEDG--FDGATAAARKEVIRNKIRAIGKMARVFSVL
||||||||||||||||||||.|||||||||||||||||||||||||||||||.||||||||| .||.    . .....||||||||||||||.|||||||
nnkaavlkyennvmnirqfnssphpywlpnfmdvftwslpfvgekvtemlvnilnicsddelekeeeeeskeesesekrkevirnkiraigklarvfsvl

REESESVLTLKGLTpTGMLPSGVLSGGKQTLqsatveaieadeaikgfspQHKITSFEEAKGLDRINERMPP
||||||||.||||| ||.||.|.||.||..|                   ..|..||||||.||.|||..||
reesesvlllkglt.tgalprgalsegkegl...................eeklssfeeakkldlineklpp
0045823 Metallo-dependent phosphatases 15-485 1.7e-166 547.3 In-house 2-472 (473) alignment 
Range on Protein: 15-485
Range on HMM: 2-472/473.0
DRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYL
|||.| |..|....|| ...|.. |.. .|.|. ||.|||.|.|...|....| ..||..|.|||.......|.||||||..||..|.|  | | ..|..
drvlklvlipvlrlltlpllfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlv

FLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRK
||||.||||..|.|....|.||||.||.  ||||||||.|.|. .. |..|.  ||.|..|..... ...|||||. ....|.|||||||....||.||.
flGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqire

LDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDV
..|. |.| .|...|.||||| ||.|.......| .|..||..|.....||.|||..|.|  | |.|.... ||..... ...|....||.||||||...
ierpleipddgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgr

YNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLR
..|.||||..........||..||||..||.|.|||..||||..||.||.|...|||.||||| ..|| ..  .  |..|..||||.|.||..|||||||
ggnlaAvlvidedlisfiqfdpsphplilplfldvfllslpfllekltellllllnivsddellededilglllleallellrnkilalgkllrvfsvlr

EESESVLTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRINERMPP
|||||||.||||||.|.|| |.|. ||..|.....||...|   . ..|.....|.||.| |..||||...
eesesvlllkgltpsgllplgllllgkelllesleealkldlineklppsllllsleeekslelinerles
PPP_1 57-322 1e-107 352.3 In-house 2-262 (264) alignment 
Range on Protein: 57-322
Range on HMM: 2-262/264.0
EESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHL
||... ..... ...|..|.|||......||||||||||.||.|||.|||....|.|||||||||||..|.|..|.|.|||. |||.|||||||||.|..
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TEYFTFKQECK-IKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRG
|....||.|..  |||...|....|.||.||||||.....|.||||||||...||.|||..|..| |. |..|| |..|  ... ..|.||....|..||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

CSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTtgfpslITIFSAPNYLDVYNNKAAVL
..|.... ....|||.||| .|.||||....||....|...      .|||||.|| .. .|..|..
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkv......vtifsasnyyeegsnrgayv
PP2Ac_SM00156 58-329 1.5e-106 348.4 In-house 3-261 (271) alignment 
Range on Protein: 58-329
Range on HMM: 3-261/271.0
ESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLT
.. .|... | ..||.|||||....|||||.||||||. ||..|.| .| |....|.|||||||||..|||..|.|.|||||||....|||||||.....
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn

EYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPledfgnEKTQEHFTHNTvRGCS
....|..|.|.||....|. ...||..||||||.....||.|||||||...|||||||.|.||.|  |...|.|||||      |.....|.... ||.|
kiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdp......eqkekgfqpsk.rgls

YFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSqttgfpSLITIFSAPNYLDVYNNKAAVLKYENNVM
....  ||.|||..|||  | ||||..| ||... ..      .|.||||||||.| ..|||||||.|.|..
vvFgedavkeflkknnlkliiRahevvdeGyeffadk......klvtifsapnycdefsnkaavlkveknlk
0049330 Metallo-dependent phosphatases 29-343 1.5e-99 325.9 In-house 3-305 (309) alignment 
Range on Protein: 29-343
Range on HMM: 3-305/309.0
LTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIE
|. . ....  .. .|.|. .|.|...|.|...|.....  .||..|.|||.......|.||||||..||..|.|  | | ..|..||||.||||..|.|
lldpllllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdsle

CVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMC
..|.|.|||.|||.  ||||||||.|.|. .. |..|.. ||.........| ...|||||. ....|||||||||....||.||.|.|. |.|..|..|
vlllllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllc

DILWSDPLEDFGNektqehFTHNTvRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENN-
|.||||||... .      |..|. ||..... . ||..||..|.|  | |.|.|.. ||... . .      |||.||||||.....|..|||..... 
dllwsdplpireg......fapnp.rglgvvfghtaverflkkngldliirghgavfgGyltffdgk......litvfsapnycgrlgnlgavleidedl

VMNIRQFNCSPHPYWL
|.....|...|....|
visfllfepvplllll
PPP_3 56-329 7e-98 319.9 In-house 2-263 (271) alignment 
Range on Protein: 56-329
Range on HMM: 2-263/271.0
LEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRH
|.|... ..... ..|| .|.||..|.||||||||||||. ||..||..||....|.|||||||||||..|.|..|.|.||||.|||...|||||||.|.
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

LTEYFTFKQECK-IKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLedfgnekTQEHFTHNTVR
......||.|..  |....||..... |..||||||.....|.|||||||.|..||.|.||.|..| |  |...| |.|..        ..|....|..|
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdp.......ekeeglenskr

GCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKsqttgfPSLITIFSAPNYLDVYNNKAAVLKYENNVM
|......  ...|||..|.|  |.||||....||.....       ...|.||||||.. ..|..|.|| |.. .
GagllFgpdvteefleknkLkliiRaHelkeeGyeilhd......gkvvtvfSapnycerasnagailkleealt
0053225 Metallo-dependent phosphatases 42-335 3e-91 298.8 In-house 8-289 (293) alignment 
Range on Protein: 42-335
Range on HMM: 8-289/293.0
RVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYP
 .|.|. .|..  .| |...|....|  .||..|.|||.......|.|||||...||..|.|  | | ..|..||||.||||..|.|....|.|||.|||
lldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllyp

KTLFLLRGNHECRHLTEYFTFKQECKIKY-SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFG
.  .|||||||...|. .. |..|.. || .....|...| ...|||||| ....|.|||||||....||.||...|. ..| .|...|.||||| . .|
dnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsg

NEKTQehfthntvRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKsqttgfPSLITIFSAPNYLDVYNNKAAVLKYENN-VMNIRQFN
  . .        ||..... . ||..||..|.|  | |.|.... ||... .      ..|.|.|||||||....|..|||..... |... .|.
wlpsy........rglgvvfghtavlrflkkngldliirghqvvpdgylpwfd......gklvtvfsapnylgrlgnlgavlaldeglvwgfklfa
subfamily_PPP1C_pd Subfamily PPP1C 54-329 2e-88 289.2 In-house 8-270 (282) alignment 
Range on Protein: 54-329
Range on HMM: 8-270/282.0
GRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHEC
 .|.|.   .....  .|| ..  ||...|||...||||||. ||..||| .|.|....||||||||||| .|.| .. | |.|| ||..|||||||||.
vklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhes

RHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPledfgnEKTQEHFTHNTv
 ...... |. ||| .|| ... . .|.|.|||||||.... ||||||||||.. |..|||. |  | | .| .||.|||||      .|... ...|. 
asinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdp......dkevlgwsend.

RGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
|| |. ..  .| .|||.|.|  |.|||.  ..||... | |      |.|.||||||.. ..|..|||. .....
rGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrq......lvtvfsapnycgefdnagavlsvdeell
subfamily_PPP4C_pd Subfamily PPP4C 51-329 5.2e-85 278.1 In-house 11-276 (288) alignment 
Range on Protein: 51-329
Range on HMM: 11-276/288.0
MKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGN
..   ..|.   .. ..   || .| |.  .|.||||||||||||.||..||.|||.  .|.||||||.||||..|.|. | | |||. ||. . |.|||
rrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgn

HECRHLTEYFTFKQECKIKY-SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEdfgnekTQeHFt
||.|..|. . | .||  || | .|.  |.. || |.|||..... .||||||||.|.|||.|| .|| .| |  ||.||.||||| .      ..  . 
hesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdped......ae.gw.

HNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
  . ||  |..   .| .| ..|..  | |||.    ||... . .      ..|..|||||     |.||.|...... 
avsprgagylfgsdvveqfneandielicrahqlvmegyklhfnek......vltvwsapnycyrcgnvaaileldeeld
subfamily_PPP2C_pd Subfamily PPP2C 44-338 5.5e-83 271.5 In-house 5-287 (290) alignment 
Range on Protein: 44-338
Range on HMM: 5-287/290.0
DILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKT
| | ..|..  .||||   ... .   ||..|.|. .. .|||||||.||||.||..|| .||.  .| ||||||||||||.|.|.| .| |||. |.. 
dklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvryker

LFLLRGNHECRHLTEYFTFKQECKIKYSE-RVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGne
. .|||||| | .|. . | .||  ||..  |.    | ||.|||.||...| .|.||||||.|.|||.||.|||..| |  ||.||.||||| .  |  
itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrgg..

ktqehFThNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQFNCSP
     ..  . ||. | .      .| ..|.|  | |||.    ||..  . .      ..||||||||     |.||.|. .... ... ||. .|
.....wg.isprgagytfgkdisekfnktngltliarahqlvmegynwshdrn......vvtifsapnycyrcgnqaailelddklkysflqfdpap
subfamily_PPP5C_pd Subfamily PPP5C 48-342 1.2e-80 263.9 In-house 26-314 (322) alignment 
Range on Protein: 48-342
Range on HMM: 26-314/322.0
AHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAP----VTVCGDIHGQFFDLMKLFEVGGSPANT-RYLFLGDYVDRGYFSIECVLYLWALKILYPK
 .. |. .|.. .||.|..|  ..|...  |..|. .    .||||||||||.||. .||. |.|...  ||| ||.|||| ||.|..| |...|.|||.
elfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPn

TLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSP-EINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGN
 .|| |||||  .. . . |..|.| ||.|.|.|   . |. |||| ..|...| |||||   .  ||||.||.||...||  | ....||||| |  | 
hfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGr

EKTQehfthntvRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKY--ENNVMNIRQFNCSPH
 ...        || .  .      .||..|||  |.|.|| .. ||.. .. .      |||.|||||| |  .||.|...   ... .....|.  .|
spsk........rGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGk......litvfsapnycdqmgnkgafitlrgddlklkfktfeaveh

PYW
|  
pdv
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 57-329 6.2e-77 251.6 In-house 25-285 (298) alignment 
Range on Protein: 57-329
Range on HMM: 25-285/298.0
EESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHL
.|.   ..|..  .|... | |...|||..||||||||. ||..||. .| | .. ||||||||||| ...| .. | | |. ||. .||||||||| ..
keedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnheceai

TEYFTFKQECKIKY-SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPledfgnEKTQEHFTHNTvRG
 . . |..||| .| | |.| .  |.|. |||.||. .. ||.|||||.....||..|.| | ....      |.||.||      |.... ...|. ||
nrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadp......enavkgwaens.rG

CSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
 |. .   .| ..|.. ..  . |||     || .. . .      |.||||||.|.. ..| |||.| .....
vsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekk......lvtifsaphycgqfdnsaavmkvdeklv
PPP_4 85-284 1e-74 243.9 In-house 1-197 (197) alignment 
Range on Protein: 85-284
Range on HMM: 1-197/197.0
VTVCGDIHGQFFDL-MKLFEVGGSPA-NTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAF
|||.||||||..|| .||...|| |. ...|.|||||||||..|.|..|.|.|||. |||...|||||||...|.....||.|.. |..........| |
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

DCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPP-AYGPMCDI-LWSDPLedfgneKTQEHfTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRA
|.||||||.....|.||||||.|...||.|....|..| |   . ..|. |||||       ..||. ..|.|||....... ....||..||| .|.|.
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpr......eaqeg.lansvrGagllFgpdvtekfleknnlkliirs

HEAQ
||..
helk
subfamily_PPP6C_pd Subfamily PPP6C 58-334 1.9e-74 243.4 In-house 17-281 (290) alignment 
Range on Protein: 58-334
Range on HMM: 17-281/290.0
ESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLT
|. . ..    . .| .| |.  . .||||||||||||.||..||  ||.  .|.|.||||.|||||.|.| . .| .||. ||. . |||||||.|..|
endlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqit

EYFTFKQECKIKYSE-RVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPlEDFgnektqEHFtHNTVRGC
. . | .||. || .  ..  |.. || |..||....| |||||||||...|||.|| ..| .| |  |..||..|||| ||       |.. . . || 
qvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edv......etw.avsprga

SYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQF
 |..    . ||.. |||  | |||.  . |.. . . .      |.|..|||||     | |..|. |..   . . |
gylfgskvtkefvhinnlklicrahqlveeglkymfdek......lvtvwsapnycyrcgnvasilaledaeereaklf
PPP_2 85-283 4.1e-74 241.6 In-house 1-197 (198) alignment 
Range on Protein: 85-283
Range on HMM: 1-197/198.0
VTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECK-IKYSERVYDACMDAFD
||||||.|||. ||..||..|.......|||||||||||..|.|..|.|.|||. |||...|||||||.........||.|..  |....||..... |.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

CLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILwsdPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEA
.||||||.....|.||||||.||..||.|.| .|..| |. |...| |   . |.. ..|..|....|..||......  ...|.|..|.|  |.||||.
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldll...eeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_PPG1_pd Subfamily PPG1 51-327 6e-74 242.0 In-house 9-285 (300) alignment 
Range on Protein: 51-327
Range on HMM: 9-285/300.0
MKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGN
 |   | |.    ..     .| .| |. .| .|||| ||.||||.|....|..||   .| |||||||||||..|.| .  | .||. ||  . |||||
qkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgn

HECRHLTEYFTFKQECKIKY--SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFG-----NEK
|| | .|. . |  ||  ||    ||..   . || | |||.....  ||||||||.. ..|.|. ||||.| |  | ..|.||||| |.        ..
hesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdr

TQEHFThNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTgfpsliTIFSAPNYLDVYNNKAAVLKYENN
  .||. .. ||. | |    | .||. |..  |.|||.    ||...  .. .      |..|||||     |||..|. ...
egqhfv.vsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnkls......tvwsapnycyrcgnkasilelyek
PPP_5_Dcr2 85-283 2.1e-70 229.8 In-house 1-198 (199) alignment 
Range on Protein: 85-283
Range on HMM: 1-198/199.0
VTVCGDIHGQFFDL-MKLFEVGGSPA-NTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIK-YSERVYDACMDA
||||||.|||..|| ..||. || |. ...|.|||||||||..|.|..|.|.|||..|||...|||||||...|.|...|..|.. | .....|... | 
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPP-AYGPMCDI-LWSDPLedfgneKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILR
||.||||||.....|.|||||||||.......|..|..| |   | ..|. |||||       ..||.   |..||....... ....||..|||  | |
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdpr......daqegcklnseRGagllfgpdvtekfleknnlkliir

AHEA
.||.
shel
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 62-327 7.9e-68 221.6 In-house 12-264 (280) alignment 
Range on Protein: 62-327
Range on HMM: 12-264/280.0
LRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFT
 |.| .   ||  .. ....||||.||||.|||. ||..||.  . | .. ||||||||||| . .| .| | | |. ||.....||||||. .. . . 
drviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkyg

FKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPledfgnEKTQEHFTHNTvRGCSYFYS
||.|.| .||. .|.   . .| |||.||.. . ||.|||||... .|||...| |  ...      |.||.||      |. .  ...|. ||.|. . 
fkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadp......enkvtgwaens.rgvsvifg

YPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENN
   | .. .. ..  | | |.  . || .. . .      |.|.||||.||. ..|.||||. ...
anvvkdltekldidliarghqvvqdgyeffadkk......lvtvfsapkylgefdnsaavlivder
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 59-326 1.6e-67 220.5 In-house 13-270 (287) alignment 
Range on Protein: 59-326
Range on HMM: 13-270/287.0
SVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTE
.  | .. .  .||.  . ||...||.|..||||||. ||...|.  | .....|||||||||||  |.| .|.|..|||.||| . |||||||.... .
kdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkink

YFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAY--GPMCDILWSDPledfgnEKTQEHFTHNTVRGC
 . ||.| | |..||.|    | |. ||| | .... ||.|||.||....||... | . . | |   | . |.||.||      || .. |  | .|. 
lyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadp......ekdaktfelnkirai

SYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYEN
|  .    | ..|.. ..  |.|||| .. || .. . .      |.|.|||| |     | .||.. ..
svvfGkkevddllkkldidlivrahevseeGyaflfdkr......lvtvfsapyysgedtnlgavvvvsk
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 72-329 9.3e-67 218.4 In-house 24-274 (284) alignment 
Range on Protein: 72-329
Range on HMM: 24-274/284.0
LRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSP------ANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQE
. .||  |.|.|||...||||||| ||. |... | |       ...||||||||||| |||| .. |.|.|.|.|. .|||||||| | .   . | .|
fwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyle

CKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFgnektqEHFtHNTVRGCSYFYSYPAV
|| .|||..|.|   || ..||.|..... .|.|||.| ..  |... ||.|  . |  | ..|. |.|| ..       |.. ... ||.   .   ||
ckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaev......egy.kesprgagkvfgakav

CEFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
 |||.. .|  ..|||.    || ..   .      |.|||||| |   ..| ||||. .....
keflkkfkldlvvrahqvvmdgyeffadrk......lvtifsapsycgqldniaavlnvdeelv
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 63-328 3.8e-66 216.2 In-house 15-267 (281) alignment 
Range on Protein: 63-328
Range on HMM: 15-267/281.0
RIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTF
 .| |  .|. .||.| .||.|..| ||.|.|| || .|||. | .......|||||||||  |.|... |..||| |.. ..|||||||  ..   . |
nvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygf

KQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPledfgNEKTQEHFThnTVRGCSYFYSY
 .||. || | ..      |. ||..||.... ||.|||||||. .||..|.  .  ...  | . |.||.||     ..|..| ..  ..|| |. .  
yvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadp.....dnkveewka..ssrGssftfGk

PAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
  | .  .. ..  | |||    .||..    .      |||.||.||| . |.| ||||| ....
nvvddvckrleveliirahqvvqdGyevlsgrk......litvfsvpnycafyknaaavlkvdetl
subfamily_PPZ_pd Subfamily PPZ 52-326 2e-64 211.0 In-house 21-282 (300) alignment 
Range on Protein: 52-326
Range on HMM: 21-282/300.0
KEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNH
|.  |..|  |.|  .   ..  . .||..  .| . ||.|||. ||..||   | |  . |||||||||||  |.| .| |.. || ||. .|||||||
knvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnh

ECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLeDFGNEktqehFtHN
||  .|  . | .||| .   ... . .|.|. |||||..  . .|||||||| .|..|.||.. |  . | .| . |.|||||  |  ||     .  .
ecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdpt.dssne.....w.ed

TVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSqttgfpSLITIFSAPNYLDVYNNKAAVLKYEN
  || || |   |. .||..  .  . |||   . || ..         ||.|.||||||   ..|  ||.   .
nergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndr......slvtvfsapnycgefdnwgavmsvse
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 68-329 2.1e-64 210.7 In-house 36-285 (299) alignment 
Range on Protein: 68-329
Range on HMM: 36-285/299.0
GASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECK
  |.. ..  ||...||. ||||||||. ||...|.. | | .. .||||||||||   .| .  | . || ||. .|.|||||||  .   . | .||.
aksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecn

IKY-SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPledfgnEKTQEHFTHNtVRGCSYFYSYPAVC
 .| | |.. .  |||. .||. |.. . ||.||||||...||| .|.| | ..||.     |.||.||      ...   .  | ||| || .    | 
krykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadp......dqsvkdwlan.vrgvsyvfgqdvva

EFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
. ... ..  . |||.  . || .. . .      |.|||||| |   ..| ||..| ..|..
dvisrldidlvarahqvvqdgyeffaskk......lvtifsaphycgqfdnsaaimkvdenlv
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 58-326 9e-61 198.7 In-house 25-283 (297) alignment 
Range on Protein: 58-326
Range on HMM: 25-283/297.0
ESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLT
|   |...    ......|......||. ||||||||| ||..||  || |  . ||||||||||| |||| .. | | |. .|  ||||||||||  . 
eervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvn

EYFTFKQECKIKY-SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSP---EINTLDDIRKLDRFKEPpAYGPMCDILWSDPLEDFGNektqehFTHNTv
. . | .||. .| | |.| |  | |. |||. |. .. ||.||||||   .  ||| .||..| .|    . ..|.||.||.  .        | .|  
kvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsg......fmenq.

RGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYEN
||.   .   || .   . .|  . |||.  . || ..   .      |.|||||| |   ..| ||..  ..
rgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrk......lvtifsaphycgqfdncaafmscde
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 61-328 2.2e-60 197.4 In-house 11-290 (302) alignment 
Range on Protein: 61-328
Range on HMM: 11-290/302.0
ALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGG-----------SPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRG
 | .| .  . |..||.| .| .|||. ||||||| ||....               | .. ...|||||||||. ||||.  ..|||.|||.   ||||
llllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrg

NHECRHLTEYFTFKQECKIKYSE----RVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAY-GPMCDILWSDPLEDFG--NE
|||.. .   ..|..| ......    ....   ..|  .|||||. .. ||||||.|| ...|.||.|..|  .  .      |.|..|||.  .    
nhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaav

KTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
... ....|.||| |. .   || .. .. ||  |.|||    .|.... . .      |.||||||.|..  .|| |||| . | 
sekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 60-328 3.5e-60 196.7 In-house 11-291 (302) alignment 
Range on Protein: 60-328
Range on HMM: 11-291/302.0
VALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGG-----------SPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLR
  | .| .  . |..||.| .| .|||. ||||||| ||....               | .. ...|||||||||. ||||.  ..|||.|||.   |||
ellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillr

GNHECRHLTEYFTFKQECKIKYSE----RVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAY-GPMCDILWSDPLEDFG--N
||||.. .   ..|..| ......    ....   ..|  .|||||. .. ||||||.|| ...|.||.|..|  .  .      |.|..|||.  .   
gnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaa

EKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
 ... ....|.||| |. .   || .. .. ||  |.|||    .|.... . .      |.||||||.|..  .|| |||| . | 
vsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnkGavlkvdtng
subfamily_PPPLV_pd Subfamily PPPLV 66-329 1.1e-57 188.5 In-house 7-281 (290) alignment 
Range on Protein: 66-329
Range on HMM: 7-281/290.0
TEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLM----KLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFT
     || .|..||....|. | ||.||.. ||.    .|. .|   . . .|||||||||| ||.| . || |||.|||  ..||||||| . ..| ..
dvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesie

FKQECKIKYSE---RVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRK----LDRFKEPPAYGPMC-DILWSDPLEDF-----GNEKTQEHF
.| |.. |. .    |..| ...|| ||||| .... .|||.|.   | |   |      |.|.|..    |.  ||||||| ||      |.  ..| |
ykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGf

THNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
 .|  || .. .|  |.  ||..|||  .|||||....|.|. .|..      |.|.||. .|    |. | .|  .... 
vdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgr......lltvfsssrycGssneaalilvdkkklr
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 65-328 1.2e-57 188.5 In-house 12-264 (284) alignment 
Range on Protein: 65-328
Range on HMM: 12-264/284.0
ITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQ
. .  ||. ..  |.....|. .|||||||| ||..||.  | |  . |||||||||||   .| .| |.| |...|. .|.|||||||  . . . | .
lfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfye

ECKIKYSE-RVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDR-FKEPPAYGPMCDILWSDPLEdFgnektQEHFTHNTvRGCSYFYSY
||. .| .  || .    |  .||.||. |. ||.|||.|  .. . ..| . | | .|       ||||||| . |     |. .  |. || || .  
ecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptn.f.....qkgwnpns.rgvsyvfgs

PAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
 |. ..|.. ..  ..|||.  . || .. . .      |.|||||| |   ..| |||.  ..|.
dalrklldrlqidlvvrahqvvqdgyeffanrr......lvtifsapfycgqfdnaaavmyvnknl
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 58-324 2.3e-57 187.2 In-house 18-275 (290) alignment 
Range on Protein: 58-324
Range on HMM: 18-275/290.0
ESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLT
..  | |. .  .||.    ||.. ||... ||||||. .|.. |.  | | . ..||||||||||  |.|  |.|. .||.|.|.. |||||||.|.. 
dkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvn

EYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPP--AYGPMCDILWSDPLEDfgnekTQEHFTHNTVRG
  . ||.|   | . |..    | |. |.| | .... ||.|||.|..|.. . .. | . . |     | . |.||.|| .|      .. .. |  |.
rlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrd.....kddtialnkqra

CSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKY
 |  .   .. ..|..  |  |.|||| .. |. .  . .      |.|.|||| |     |  |... 
isvvfgkkglddllkklalslivrahevkeegfnflfdkk......lvtvfsapyysgndtnlgaiatv
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 110-328 4.5e-57 186.6 In-house 100-305 (317) alignment 
Range on Protein: 110-328
Range on HMM: 100-305/317.0
NTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTL
. .||||||||||| |||| |. | |||.|||. .|||||||| | .   . | .|.| .||...|.|   || .|||.|..|.. ||.|||.| |.  |
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldl

DDIRKLDRFKEPPAYGPMCDILWSDPledfgnEKTQEHFtHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAP
. . ||.|  . |  | ..|. |.||      ... ... ... || .  .  .|| |||.. .|  ..|||.    || ..   .      |.||||||
kqldklkrpldipdvGvladltwadp......daevkgy.kesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrk......lvtifsap

NYLDVYNNKAAVLKYENNV
.|    .| ||||. ....
sycGqldniaavlsvdkkl
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 63-334 3.9e-55 180.3 In-house 13-272 (280) alignment 
Range on Protein: 63-334
Range on HMM: 13-272/280.0
RIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTF
 ||    .|. .| || . .||. | |||| |. |. .||.. |   . . .|||||||||   || .. |..||| |   ..|||||||   . . . |
aiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygf

KQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEdfgneKTQEHFtHnTVRGCSYFYSY
  ||. ||   ..     .|. .|...|.... ||.|||||||.  || ||.. |  ||   | . |.||||| .     | .  | | ..|| ||..  
yvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptn.....kgegwf.h.sirgisymfgk

PAVCEFLQHNNLLSILRAHEAQDAGYRMYrksqtTGfPSLITIFSAPNYLDVYNNKAAVLKYENNVM-NIRQF
  | .  .  ..  |.|||.  . || |      .|   |||.|| |||   . | |||.  . |.  ...|.
gvveqacksleidliirahqvvqdgyemm.....ag.rrlitvfsvpnycaqftnaaavvclnanlqvsfqql
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 63-327 7.8e-52 169.3 In-house 27-281 (307) alignment 
Range on Protein: 63-327
Range on HMM: 27-281/307.0
RIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTF
 .| |  .|.  || |.||| |. | ||.|||| ||...| . | | .| |.| ||||||| .|.||.| |.. || ||. . |||||||  .. . ..|
nviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygf

KQECKI---KYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTqehfthnTVRGCSYF
 .||     |  | ..     .|. ||..||.  . ||.|||||| .  ||..|.  .    |  | . |.||.||     . |.       . ||  . 
yeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewka.......ssrgsgft

YSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSqttgfpSLITIFSAPNYLDVYNNKAAVLKYENN
.    . .  .   .  |.|||.    || .           |||||||| | ..|.|  .||| .. 
fgtnviddvckrlgveliirahqmcfdgywvlsgr......klitifsapmycnfyknagcvlkvdet
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 78-324 3.6e-50 164.1 In-house 2-242 (263) alignment 
Range on Protein: 78-324
Range on HMM: 2-242/263.0
LLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYS-ERVYD
||...||. .||| |||. ||...|.  |. ..|.||||||||||| .|.| .. |..||.  |. ..||||||| . . . . |. | | ..  | ||.
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

----ACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGP-MCDILWSDPledfgnEKTQEHFTHNTVRGCSYFYSYPAVCEFLQH
       . |  .||.|..... ||.|||.|| ...||||| .    |     |  ||.||.||      ||  . |  | .|  |  .    | .. ..
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadp......ekdakgfepnkiraisnvfgkkevddlckr

NNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKY
 ..  |.|||.  . || ..   .      |||.|||  |     | |||.  
ldidlivrahqvveygyaffadrr......litvfsasryqielcnyaavvvv
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 111-327 1.3e-44 145.7 In-house 120-323 (339) alignment 
Range on Protein: 111-327
Range on HMM: 120-323/339.0
TRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLD
 |||||||||||| ||.| |. | |||. ||  ..||||||| | .   . | .| . .|  ..|..  . |. .|..|..|.  .|.|||.|  . ...
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

DIRKLDRFKEPPAYGPMCDILWSDPledfgnEKTqEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPN
..  . |  | |  | . |. |.||      . | |.  . . ||.|. .  ||.  ||.. .|  ..| |.  . || ..   .      |.|||||||
qfsvfkrpleipdvgvltdltwadp......dpt.ekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrr......lvtifsapn

YLDVYNNKAAVLKYENN
|    .| |||.  ...
ycgqndntaavfsidkk
Metallophos Calcineurin-like phosphoesterase 84-284 1.2e-43 142.7 Pfam-A 2-199 (200) alignment 
Range on Protein: 84-284
Range on HMM: 2-199/200.0
PVTVCGDIHGQFFDL----MKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYL--WALKILYPKTLFLLRGNHECRHLTEYFTFKQECK----------
...|.||.||.. ||    ..|....... .. .|||||.||||  |.|.  .|  ..||.|.|. .||||||||........ |. |.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------IKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIrkldrfkeppaygpmcdilwsdpledfgnek
                         ..  ...... . |..|||.|| ....|..||.||.. .. |||                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

tqehfthntvrgCSYFYSYPAVCEFLQHNNLLSILRAHEAQ
            .|. ....|....|. ...  .||.|. .
............gselfgpdalekllekygvdlvlrGHtHk
subfamily_PPP7C_pd Subfamily PPP7C 49-219 3e-35 114.7 In-house 26-203 (383) alignment 
Range on Protein: 49-219
Range on HMM: 26-203/383.0
HLMKEGRLEESVALRIITEGASILRQEKNLLDIDA----PVTVCGDIHGQFFDLMKLFEVGGSPANT-RYLFLGDYVDRGYFSIECVLYLWALKILYPKT
.. .. .|     | |. | . .|.| .|.  . .     ||||||.||.. ||. ..   | |..   |.| ||.||||  |.| .| | || ..||| 
afkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypke

LFLLRGNHECRHLTEYFTFKQECKIKY---SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSpEINTLDDIRKLDRFK
..| |||||   |   . | .| . ||   ....     | |  ||||.|.... | ||||.| ..  |. . |..| |
vylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkiersk
subfamily_PPP7C_pd Subfamily PPP7C 227-329 3.4e-13 42.1 In-house 237-326 (383) alignment 
Range on Protein: 227-329
Range on HMM: 237-326/383.0
MCDILWSDPledfgneKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYEN
. |||||||       |..|  . ||.||   ..      ..||. ||  ..|.|| .  || .  ...      ..||||| || ..  |. | .|  .
vldilwsdp.......kakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkk......vltifsasnyyeeGsnrGayvklgk

NVM
...
dlt
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 72-109 4.8e-10 32.1 In-house 25-62 (317) alignment 
Range on Protein: 72-109
Range on HMM: 25-62/317.0
LRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPA
. .|.  |...||||..||||||| ||. |... | | 
fwkeplkleleapvtivGdihGqfedllalldlnGwpl
subfamily_YNL217W_pd Subfamily YNL217W 85-202 2.1e-06 20.4 In-house 12-136 (235) alignment 
Range on Protein: 85-202
Range on HMM: 12-136/235.0
VTVCGDIHGQFFDLMKLFE--VGGSPANTRYLFLGDYVDRGYFSIECVLYLwalkilYPKTLFLLRGNHECRHLTEYFTFKQECKIK---------YS-E
. | ||.|| . .|..|..  .||   |   ...|| ...|  |.| | |.        .    ..||||   | .|   |..  ..         .   
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsfles

RVYDACMDAFDCLPLA-ALMNQQFLCVHGGL
.. .| |.    |. .  .  .. | ||.||
klskadmeyarelgfsldipsdellvvhaGl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 72-109 4e-06 19.1 In-house 27-64 (339) alignment 
Range on Protein: 72-109
Range on HMM: 27-64/339.0
LRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPA
.  |  .| ..||. | ||||||| ||. .... | | 
iwsepiflkleapicvmgdihgqfddllamldmngwpl