Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_PPP3C_pd | Subfamily PPP3C | 25-495 | 8.4e-259 | 851.8 | In-house | 1-452 (452) | alignment | ||
Range on Protein: 25-495
Range on HMM: 1-452/452.0
RVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLF
||||.||.|....||.||||| .|.|...|||.|..||||..|| ||.||.|.|..|..|||..||||||||.|||||||.||.|||||||.||.|.|||
rvvkkvplpkskklteeevfdetgkpklevlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylf
LGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRL
||||||||||||||||||. ||| ||||||||||||||||||||||||.||||||||.||.||||.|||||||||||||||||||||||||..||||..|
lGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkl
DRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVY
||||||||.||.|||||||| ||.|.||..|.|..|.||||||||.| |||||||.|.|||||||||||||||||||||..||||||||.||||||||||
drfkeppasGplcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvy
NNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQ-FDVGSAAARKEIIRNKIRAIGKMARVFSVL
||||||||||||||||||||.|||||||||||||||||||||||||||||||.|.|||||||..| |.. . ....|||.||||||||||.|||||||
nnkaavlkyennvmnirqfnssphpywlpnfmdvftwslpfvgekvtemlvnilnicsddelekeeeeeskeesesekrkevirnkiraigklarvfsvl
REESESVLTLKGLTpTGMLPSGVLAGGRQTLqsatveaieaekairgfspPHRICSFEEAKGLDRINERMPP
||||||||.||||| ||.||.|.|..|...| ....||||||.||.|||..||
reesesvlllkglt.tgalprgalsegkegl...................eeklssfeeakkldlineklpp
|
|||||||||
0045823 | Metallo-dependent phosphatases | 24-495 | 4.6e-162 | 532.7 | In-house | 2-472 (473) | alignment | ||
Range on Protein: 24-495
Range on HMM: 2-472/473.0
DRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYL
|||.| |..|....|| ...|.| |.. .|.|..||.|||.. || .|....| . ||..|....|....|.|.||||||..||..|.| | | ..|..
drvlklvlipvlrlltlpllfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlv
FLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRR
||||.||||..|.|....|. |||.||. ||||||||.|.|. .. |..|. ||.|..||...| ..||||||......|.|||||||....||.||.
flGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqire
LDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDV
..|. |.| .|...||||||| ||.|.......| .|..||..|.....||.|||..|.| |.|.|.... ||..... ...|....||.||||||...
ierpleipddgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgr
YNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMtEGEDQFDVGSAAARKEIIRNKIRAIGKMARVFSVL
..|.||||..........||..||||..||.|.|||..||||..||.||.|...|.|.|||||. | || ... |..|..||||.|.||..||||||
ggnlaAvlvidedlisfiqfdpsphplilplfldvfllslpfllekltellllllnivsddell.ededilglllleallellrnkilalgkllrvfsvl
REESESVLTLKGLTPTGMLPSGVLAGGRQTLQSATVEAIEAEKAIRGFSPPHRICSFEEAKGLDRINERMPP
||||||||.||||||.|.|| |.|. |...|.....||.... . ..| . . |.||.| |..||||...
reesesvlllkgltpsgllplgllllgkelllesleealkldlineklppsllllsleeekslelinerles
|
|||||||||
PP2Ac_SM00156 | 67-338 | 1.2e-107 | 352.0 | In-house | 3-261 (271) | alignment | |||
Range on Protein: 67-338
Range on HMM: 3-261/271.0
EEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLT
.| .|....| ..||..||...||.||.||.||||||. ||..|.| .| |....|.|||||||||..|||..|.|. ||||||....|||||||.....
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn
EYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPsedfgnEKSQEHFSHNTvRGCS
....|..|.|.||....|| ..|||..||||||.....||.|||||||...|||||.|.|.||.| |...||||||| |.....|.... ||.|
kiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdp......eqkekgfqpsk.rgls
YFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSqttgfpSLITIFSAPNYLDVYNNKAAVLKYENNVM
.... ||.|||..||| ||||||..| ||... .. .|.||||||||.| ..|||||||.|.|..
vvFgedavkeflkknnlkliiRahevvdeGyeffadk......klvtifsapnycdefsnkaavlkveknlk
|
|||||||||
PPP_1 | 67-331 | 1.6e-107 | 351.7 | In-house | 3-262 (264) | alignment | |||
Range on Protein: 67-331
Range on HMM: 3-262/264.0
EEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLT
|| . ..... . .|..|....||...|||||||||||.||.|||.|||....|.|||||||||||..|.|..|.|..||. ||..|||||||||.|..|
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt
EYFTFKQECK-IKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGC
....||.|.. |||...|......|| ||||||.....|.||||||||...||.||...|..| |. |..||||..| .... ..|.||.. .|..||.
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa
SYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTtgfpslITIFSAPNYLDVYNNKAAVL
.|.... ....|||.||| .||||||....||....|... .|||||.|| .. .|..|..
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkv......vtifsasnyyeegsnrgayv
|
|||||||||
0049330 | Metallo-dependent phosphatases | 47-352 | 9.9e-98 | 320.0 | In-house | 12-305 (309) | alignment | ||
Range on Protein: 47-352
Range on HMM: 12-305/309.0
DGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLK
.. .|.|...| |.....|| .|..... ||. |....|....|.|.||||||..||..|.| | | ..|..||||.||||..|.|..|.|. ||
lilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalk
ILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSE
.|||. ||||||||.|.|. .. |..|.. ||.....|.... ..||||||......|||||||||....||.||.|.|. |.|..|..||||||||..
llypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplp
DFGNeksqehFSHNTvRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENN-VMNIRQFNC
.. . | .|. ||....... ||..||. |.| |||.|.|.. ||... . . |||.||||||.....|..|||..... |.....|..
ireg......fapnp.rglgvvfghtaverflkkngldliirghgavfgGyltffdgk......litvfsapnycgrlgnlgavleidedlvisfllfep
SPHPYWL
.|....|
vplllll
|
|||||||||
PPP_3 | 66-338 | 4.1e-96 | 314.1 | In-house | 3-263 (271) | alignment | |||
Range on Protein: 66-338
Range on HMM: 3-263/271.0
DEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHL
.|. . ..... . || |....|..||.|||||||||. ||..||..||....|.|||||||||||..|.|..|.|..|||.||....|||||||.|..
senelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqi
TEYFTFKQECK-IKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSedfgnekSQEHFSHNTVRG
.....||.|.. |....||....| |. ||||||.....|.|||||||.|..||.|..|.|..| | |...|||.|... ..|.. .|..||
nkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdp.......ekeeglenskrG
CSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKsqttgfPSLITIFSAPNYLDVYNNKAAVLKYENNVM
..... ...|||..|.| ||||||....||..... ...|.||||||.. ..|..|.|| |.. .
agllFgpdvteefleknkLkliiRaHelkeeGyeilhd......gkvvtvfSapnycerasnagailkleealt
|
|||||||||
0053225 | Metallo-dependent phosphatases | 51-344 | 4e-91 | 298.4 | In-house | 8-289 (293) | alignment | ||
Range on Protein: 51-344
Range on HMM: 8-289/293.0
RVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYP
.|.|...|.. ...|| .|....| ||..|....|....|.|.|||||...||..|.| | | ..|..||||.||||..|.|....|. ||.|||
lldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllyp
STLFLLRGNHECRHLTEYFTFKQECKIKY-SERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFG
. .|||||||...|. .. |..|.. || .......... ..|||||||.....|.|||||||....||.||...|. ..| .|...|||||||.. .|
dnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsg
NEKSQehfshntvRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKsqttgfPSLITIFSAPNYLDVYNNKAAVLKYENN-VMNIRQFN
.|. ||....... ||..||..|.| |||.|.... ||... . ..|.|.|||||||....|..|||..... |... .|.
wlpsy........rglgvvfghtavlrflkkngldliirghqvvpdgylpwfd......gklvtvfsapnylgrlgnlgavlaldeglvwgfklfa
|
|||||||||
subfamily_PPP1C_pd | Subfamily PPP1C | 68-338 | 6.2e-87 | 284.4 | In-house | 13-270 (282) | alignment | ||
Range on Protein: 68-338
Range on HMM: 13-270/282.0
EIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTE
. ..... .|| .. ...|.|||....||||||. ||..||| .|.|....||||||||||| .|.| .. | ..|| ||..|||||||||. ....
aeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasinr
YFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDfgneksQEHFSHNTvRGCSY
.. |. ||| .|| ..... ...|. ||||||.... ||||||||||.. |..||.. | | | | .|||||||| .. .. .|.|. || |.
iyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdke......vlgwsend.rGvsf
FYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
.. .| .|||.|.| |.|||. ..||... | | |.|.||||||.. ..|..|||. .....
tfgkdvvekflqkndldlivrahqvvedGyeffakrq......lvtvfsapnycgefdnagavlsvdeell
|
|||||||||
subfamily_PPP4C_pd | Subfamily PPP4C | 65-338 | 1.6e-83 | 273.3 | In-house | 16-276 (288) | alignment | ||
Range on Protein: 65-338
Range on HMM: 16-276/288.0
VDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRH
. || .. .. || | . .|..|.||||||||||.||..||.|||. .|.||||||.||||..|.|. | | .||. || . |.|||||.|.
ikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrq
LTEYFTFKQECKIKY-SERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSqehfshntVR
.|. . | .|| || | .|.. |.| || |.|||..... .||||||||.|.|||.|| .|| .| | ||.|||||||| . | | |
itqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaegwavs........pr
GCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
| |.. .| .| ..|.. |.|||. ||... . . ..|..||||| |.||.|......
gagylfgsdvveqfneandielicrahqlvmegyklhfnek......vltvwsapnycyrcgnvaaileldeeld
|
|||||||||
subfamily_PPP5C_pd | Subfamily PPP5C | 57-351 | 4e-82 | 268.8 | In-house | 26-314 (322) | alignment | ||
Range on Protein: 57-351
Range on HMM: 26-314/322.0
NHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAP----ITVCGDIHGQFFDLMKLFEVGGSPANT-RYLFLGDYVDRGYFSIECVLYLWVLKILYPS
... |. .. . .||.|. | ..|... ...|.. . .||||||||||.||. .||. |.|... ||| ||.|||| ||.|..| |. .|.|||
elfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPn
TLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLS-PEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGN
.|| ||||| .. . . |..|.| ||.|.|.. | |..|||| ..|...| ||||| . ||||.|..||...|| | ...|||||| | |
hfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGr
EKSQehfshntvRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKY--ENNVMNIRQFNCSPH
.|. || . . .||..||| |||.|| .. ||.. .. . |||.|||||| | .||.|... ... .....|. .|
spsk........rGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGk......litvfsapnycdqmgnkgafitlrgddlklkfktfeaveh
PYW
|
pdv
|
|||||||||
subfamily_PPP2C_pd | Subfamily PPP2C | 53-347 | 2.9e-81 | 265.9 | In-house | 5-287 (290) | alignment | ||
Range on Protein: 53-347
Range on HMM: 5-287/290.0
DVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPST
| | ..| . ...|. ..... ||..|. . ||..|.|||||.||||.||..|| .||. .| ||||||||||||.|.|.| .| .||. |..
dklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvryker
LFLLRGNHECRHLTEYFTFKQECKIKYSE-RVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNE
. .|||||| | .|. . | .|| ||.. |.. . || |||.||...| .|.||||||.|.|||.|| |||..| | ||.|||||||| . |
itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrggwg
KSQehfshntvRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQFNCSP
|. ||. | . .| ..|.| |.|||. ||.. . . ..|||||||| |.||.|. .... ... ||. .|
isp........rgagytfgkdisekfnktngltliarahqlvmegynwshdrn......vvtifsapnycyrcgnqaailelddklkysflqfdpap
|
|||||||||
subfamily_Cele-PPP-Subfam4_pd | Subfamily Cele-PPP-Subfam4 | 65-338 | 8.9e-78 | 254.3 | In-house | 24-285 (298) | alignment | ||
Range on Protein: 65-338
Range on HMM: 24-285/298.0
VDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRH
..|| ..|.. |... |...||.|||.||||||||. ||..||. .| | .. ||||||||||| ...| .. | . |. ||. .||||||||| .
ikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnhecea
LTEYFTFKQECKIKY-SERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPsedfgnEKSQEHFSHNTvR
. . . |..||| .| | |.|.. ..|..|||.||. .. ||.|||||.....||..|.| | .... ||||.|| |.... ...|. |
inrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadp......enavkgwaens.r
GCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
| |. . .| ..|.. .. ..||| || .. . . |.||||||.|.. ..| |||.| .....
GvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekk......lvtifsaphycgqfdnsaavmkvdeklv
|
|||||||||
subfamily_PPG1_pd | Subfamily PPG1 | 75-336 | 1.4e-74 | 244.0 | In-house | 24-285 (300) | alignment | ||
Range on Protein: 75-336
Range on HMM: 24-285/300.0
NEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQE
. .| .| .||...|.|| ||.||||.|....|..|| .| |||||||||||..|.| . | |||. ||| . ||||||| | .|. . | |
dklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyte
CKIKY--SERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFG-----NEKSQEHFShNTVRGCSY
| || ||.. | || | |||..... ||||||||.. ..|.|. ||||.| | | ..||||||| |. ... .|| .. ||. |
clrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfv.vsqrgagy
FYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTgfpsliTIFSAPNYLDVYNNKAAVLKYENN
| | .||.||.. |||||. ||... .. . |..||||| |||..|. ...
sygkdvvekflrnndmnriirahqlcnegyqilfdnkls......tvwsapnycyrcgnkasilelyek
|
|||||||||
subfamily_PPP6C_pd | Subfamily PPP6C | 72-343 | 8.2e-74 | 241.3 | In-house | 22-281 (290) | alignment | ||
Range on Protein: 72-343
Range on HMM: 22-281/290.0
RIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTF
.. . . .| .| .. |..|.||||||||||.||..|| ||. .|.|.||||.|||||.|.| . .| .||. ||. . |||||||.|..|. . |
klcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygf
KQECKIKYSE-RVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPsEDFgneksqEHFsHNTVRGCSYFYN
.||. || . .. |.. || |..||....| |||||||||...|||.|| ..| .| | |..|||.|||| || |.. . . || |..
ydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edv......etw.avsprgagylfg
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQF
. ||...||| |.|||. . |.. . . . |.|..||||| | |..|. |.. . . |
skvtkefvhinnlklicrahqlveeglkymfdek......lvtvwsapnycyrcgnvasilaledaeereaklf
|
|||||||||
PPP_4 | 94-293 | 1.7e-73 | 239.9 | In-house | 1-197 (197) | alignment | |||
Range on Protein: 94-293
Range on HMM: 1-197/197.0
ITVCGDIHGQFFDL-MKLFEVGGSPA-NTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAF
.||.||||||..|| .||...|| |. ...|.|||||||||..|.|..|.|. ||. ||....|||||||...|.....||.|.. |........... |
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf
DSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPP-AFGPMCDL-LWSDPSedfgneKSQEHfSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRA
| ||||||.....|.||||||.|...||.|.|..|..| | . ..|| |||||. ..||. ..|.|||..... . ....||..||| .|||.
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpr......eaqeg.lansvrGagllFgpdvtekfleknnlkliirs
HEAQ
||..
helk
|
|||||||||
PPP_2 | 94-292 | 3e-73 | 238.7 | In-house | 1-197 (198) | alignment | |||
Range on Protein: 94-292
Range on HMM: 1-197/198.0
ITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECK-IKYSERVYEACMEAFD
.|||||.|||. ||..||..|.......|||||||||||..|.|..|.|..||. ||....|||||||.........||.|.. |....||....| |.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe
SLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLwsdPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEA
||||||.....|.||||||.||..||.|.. .|..| |. |...||| ..|.. ..|..|.. .|..||...... ...|.|..|.| ||||||.
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldll...eeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
|
|||||||||
PPP_5_Dcr2 | 94-292 | 1.4e-69 | 227.1 | In-house | 1-198 (199) | alignment | |||
Range on Protein: 94-292
Range on HMM: 1-198/199.0
ITVCGDIHGQFFDL-MKLFEVGGSPA-NTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIK-YSERVYEACMEA
.|||||.|||..|| ..||. || |. ...|.|||||||||..|.|..|.|. ||..||....|||||||...|.|...|..|.. | .....|... .
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv
FDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPP-AFGPMCDL-LWSDPSedfgneKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIR
|| ||||||.....|.|||||||||..........|..| | | ..|| |||||. ..||. |..||....... ....||..||| |||
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdpr......daqegcklnseRGagllfgpdvtekfleknnlkliir
AHEA
.||.
shel
|
|||||||||
subfamily_Cele-PPP-4C_pd | Subfamily Cele-PPP-4C | 71-336 | 4e-69 | 225.8 | In-house | 12-264 (280) | alignment | ||
Range on Protein: 71-336
Range on HMM: 12-264/280.0
LRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFT
|.|.. || ..||.||.||..||||.|||. ||..||. . | .. ||||||||||| . .| .| | |. || ....||||||. .. . .
drviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkyg
FKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNeksqehFSHNtVRGCSYFYN
||.|.| .||. .|. | .|||||.||.. . ||.|||||... .|||...| | ... ||||.||... ...| ||.|. .
fkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtg......waen.srgvsvifg
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENN
| .. . .. |.| |. . || .. . . |.|.||||.||. ..|.||||. ...
anvvkdltekldidliarghqvvqdgyeffadkk......lvtvfsapkylgefdnsaavlivder
|
|||||||||
subfamily_Cele-PPP-Subfam3_pd | Subfamily Cele-PPP-Subfam3 | 60-335 | 8e-69 | 224.7 | In-house | 6-270 (287) | alignment | ||
Range on Protein: 60-335
Range on HMM: 6-270/287.0
VKEGRVDEEIaLRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGN
| .. |..| | .... ||. ....|||||||..||||||. ||...|. | .....||||||||||| |.| .|.|. |||.|| . |||||
vldafsdkdi.levlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGn
HECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAF--GPMCDLLWSDPSEDfgneksQEHF
||.... . . ||.| | |..||.|. . |. ||| | .... ||.|||.||....||... | . . | | | . ||||.||..| .. |
hevkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd......aktf
SHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYEN
| .|. | . | ..|.. .. |.|||| .. || .. . . |.|.|||| | | .||.. ..
elnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkr......lvtvfsapyysgedtnlgavvvvsk
|
|||||||||
subfamily_Cele-PPP-Subfam2_pd | Subfamily Cele-PPP-Subfam2 | 67-337 | 1.2e-66 | 217.8 | In-house | 11-267 (281) | alignment | ||
Range on Protein: 67-337
Range on HMM: 11-267/281.0
EEIaLRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLT
||| .| | ||. ||...|...||.| ||.|.|| || .|||. | .......||||||||| |.|... |..||| |. ..||||||| ..
eei.envireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvn
EYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEdfgneKSQEHFsHnTVRGCS
. | .||. || | .. . |. ||..|| ... ||.|||||||. .||..| . ... | . ||||.||.. |..| . . ..|| |
kiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdn.....kveewk.a.ssrGss
YFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
. . | . .. .. ||||| .||.. . |||.||.||| . |.| ||||| ....
ftfGknvvddvckrleveliirahqvvqdGyevlsgrk......litvfsvpnycafyknaaavlkvdetl
|
|||||||||
subfamily_Cele-PPP-1A_pd | Subfamily Cele-PPP-1A | 80-338 | 8.2e-66 | 215.3 | In-house | 23-274 (284) | alignment | ||
Range on Protein: 80-338
Range on HMM: 23-274/284.0
ILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSP------ANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQ
.. .|| .|.|||....||||||| ||. |... | | ...||||||||||| |||| .. |. .|.|.| .|||||||| | . . | .
lfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyl
ECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFgneksqEHFsHNTVRGCSYFYNYPA
||| .|||..||| || ..||.|..... .|.|||.| .. |... .|.| . | | ..|| |.||... |.. ... ||. . |
eckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaev......egy.kesprgagkvfgaka
VCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
| |||.. .| ..|||. || .. . |.|||||| | ..| ||||. .....
vkeflkkfkldlvvrahqvvmdgyeffadrk......lvtifsapsycgqldniaavlnvdeelv
|
|||||||||
subfamily_Cele-PPP-4B_pd | Subfamily Cele-PPP-4B | 78-338 | 2e-65 | 214.0 | In-house | 37-285 (299) | alignment | ||
Range on Protein: 78-338
Range on HMM: 37-285/299.0
AAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKI
.. . ...|||||| ||||||||. ||...|.. | | .. .|||||||||| .| . | . || || .|.||||||| . . | .||.
ksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecnk
KY-SERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEdfgnekSQEHFSHNtVRGCSYFYNYPAVCE
.| | |.. . .||. .||. |.. . ||.||||||...||| .| | | ..||. ||||.|| . | . | ||| || . | .
rykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdq......svkdwlan.vrgvsyvfgqdvvad
FLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
... .. . |||. . || .. . . |.|||||| | ..| ||..| ..|..
visrldidlvarahqvvqdgyeffaskk......lvtifsaphycgqfdnsaaimkvdenlv
|
|||||||||
subfamily_PPZ_pd | Subfamily PPZ | 70-335 | 7.7e-64 | 209.1 | In-house | 30-282 (300) | alignment | ||
Range on Protein: 70-335
Range on HMM: 30-282/300.0
ALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYF
|.| . .. . ...|. .. . ||.|||. ||..|| | | . ||||||||||| |.| .| |.. || || .||||||||| .| .
ilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrvy
TFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSeDFGNEksqehFSHNtVRGCSYFY
| .||| . ..... ...|..|||||.. . .|||||||| . ..|.||.. | . | || . |||||||. | || . | || || |
gfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdpt.dssne.....wedn.ergvsycy
NYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSqttgfpSLITIFSAPNYLDVYNNKAAVLKYEN
| |. .||.. . . ||| . || .. ||.|.|||||| ..| ||. .
nkvainkflnkfgfdlvcrahmvvedgyeffndr......slvtvfsapnycgefdnwgavmsvse
|
|||||||||
subfamily_Cele-PPP-4D_pd | Subfamily Cele-PPP-4D | 65-335 | 2.5e-62 | 203.8 | In-house | 23-283 (297) | alignment | ||
Range on Protein: 65-335
Range on HMM: 23-283/297.0
VDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRH
. || |.... .....|.|.||.||| ||||||||| ||..|| || | . ||||||||||| |||| .. | |. .|. ||||||||||
iteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecef
LTEYFTFKQECKIKY-SERVYEACMEAFDSLPLAALLNQQFLCVHGGLSP---EIHTLDDIRRLDRFKEPpAFGPMCDLLWSDPSEDFGNeksqehFSHN
. . . | .||. .| | |.| | . |. |||. |. .. ||.|||||| . ||| .|...| .| . ..||||.|| . | .|
vnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsg......fmen
TvRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYEN
||. . || . . .| . |||. . || .. . |.|||||| | ..| ||.. ..
q.rgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrk......lvtifsaphycgqfdncaafmscde
|
|||||||||
subfamily_Cele-PPP-5_pd | Subfamily Cele-PPP-5 | 71-337 | 1.3e-60 | 198.1 | In-house | 12-290 (302) | alignment | ||
Range on Protein: 71-337
Range on HMM: 12-290/302.0
LRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGG-----------SPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGN
| .|.. . |..|||..|. .|.|. ||||||| ||.... | .. ...|||||||||. ||||. .. ||.|||. |||||
lllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgn
HECRHLTEYFTFKQECKIKYSE----RVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAF-GPMCDLLWSDPSEDF--GNEK
||.. . ..|..| ...... ...| |.| .|||||. .. ||||||.|| ...|.||....| . . |||..|| . .
hetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaavs
SQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
.. .. .|.||| |. .| || .. .. || |.||| .|.... . . |.||||||.|.. .|| |||| . |
ekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnkGavlkvdtng
|
|||||||||
subfamily_Cele-PPP-Subfam5_pd | Subfamily Cele-PPP-Subfam5 | 71-337 | 2.1e-60 | 197.5 | In-house | 13-291 (302) | alignment | ||
Range on Protein: 71-337
Range on HMM: 13-291/302.0
LRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGG-----------SPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGN
| .|.. . |..|||..|. .|.|. ||||||| ||.... | .. ...|||||||||. ||||. .. ||.|||. |||||
lllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgn
HECRHLTEYFTFKQECKIKYSE----RVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAF-GPMCDLLWSDPSEDF--GNEK
||.. . ..|..| ...... ...| |.| .|||||. .. ||||||.|| ...|.||....| . . |||..|| . .
hetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaavs
SQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
.. .. .|.||| |. .| || .. .. || |.||| .|.... . . |.||||||.|.. .|| |||| . |
ekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnkGavlkvdtng
|
|||||||||
subfamily_Cele-PPP-3B_pd | Subfamily Cele-PPP-3B | 55-333 | 5.9e-59 | 192.4 | In-house | 7-275 (290) | alignment | ||
Range on Protein: 55-333
Range on HMM: 7-275/290.0
LKNHLVKEGRVDEEIaLRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLF
|. . | .. |..| | |... ||. ...||||||.. ||||||. .|.. |. | | . ..|||||||||| |.| |.|. .||.|. ..
llkygvldafsdkdi.leilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvh
LLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPP--AFGPMCDLLWSDPSEDfgnek
|||||||.|.. . ||.| | . |.. . |. |.| | .... ||.|||.|..|.. . .. | . . | | . ||||.||..|
llrgnhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrd.....
SQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKY
.. .. | |. | . .. ..|.. | |.|||| .. |. . . . |.|.|||| | | |...
kddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkk......lvtvfsapyysgndtnlgaiatv
|
|||||||||
subfamily_PPPLV_pd | Subfamily PPPLV | 73-338 | 5e-58 | 189.7 | In-house | 5-281 (290) | alignment | ||
Range on Protein: 73-338
Range on HMM: 5-281/290.0
IINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLM----KLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEY
. . || |. ..|...|. | ||.||.. ||. .|. .| . . .|||||||||| ||.| . || ||.|||| ..||||||| . ..|
lcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqes
FTFKQECKIKYSE---RVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRR----LDRFKEPPAFGPMC-DLLWSDPSEDF-----GNEKSQE
...| |.. |. . |.|| ...|| ||||| .... .|||.|. |.| | |.|.|.. |. |.|||||.|| |. .|
ieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlne
HFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
| .| || .. . |. ||..||| ..||||....|.|. .|.. |.|.||. .| |. | .| ....
GfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgr......lltvfsssrycGssneaalilvdkkklr
|
|||||||||
subfamily_Cele-PPP-4A_pd | Subfamily Cele-PPP-4A | 74-337 | 6.1e-58 | 189.5 | In-house | 12-264 (284) | alignment | ||
Range on Protein: 74-337
Range on HMM: 12-264/284.0
INEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQ
. . .|. .. .|||..|| .|||||||| ||..||. | | . ||||||||||| .| .| |. |...| .|.||||||| . . . | .
lfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfye
ECKIKYSE-RVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDR-FKEPPAFGPMCDLLWSDPSEdFgneksQEHFSHNTvRGCSYFYNY
||. .| . || . | .||.||. |. ||.|||.| .. . ..| . | | .| |.|||||.. | |. . |. || || .
ecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptn.f.....qkgwnpns.rgvsyvfgs
PAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
|. ..|. .. ..|||. . || .. . . |.|||||| | ..| |||. ..|.
dalrklldrlqidlvvrahqvvqdgyeffanrr......lvtifsapfycgqfdnaaavmyvnknl
|
|||||||||
subfamily_Cele-PPP-2B_pd | Subfamily Cele-PPP-2B | 71-343 | 7.8e-57 | 185.8 | In-house | 12-272 (280) | alignment | ||
Range on Protein: 71-343
Range on HMM: 12-272/280.0
LRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFT
. || ||. | ..| |||| | |||| |. |. .||.. | . . .||||||||| || .. |..||| | ..||||||| . . .
iaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiyg
FKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEdfgneKSQEHFsHnTVRGCSYFYN
| ||. || .. .|. .|...|.... ||.|||||||. || || . | || | . |||||||.. | . | | ..|| ||..
fyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptn.....kgegwf.h.sirgisymfg
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYrksqtTGfPSLITIFSAPNYLDVYNNKAAVLKYENNVM-NIRQF
| . .. .. |||||. . || | .| |||.|| ||| . | |||. . |. ...|.
kgvveqacksleidliirahqvvqdgyemm.....ag.rrlitvfsvpnycaqftnaaavvclnanlqvsfqql
|
|||||||||
subfamily_Cele-PPP-Subfam1_pd | Subfamily Cele-PPP-Subfam1 | 119-337 | 1.8e-56 | 184.6 | In-house | 100-305 (317) | alignment | ||
Range on Protein: 119-337
Range on HMM: 100-305/317.0
NTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTL
. .||||||||||| |||| |. | ||.||| .|||||||| | . . | .|.| .||...||| || |||.|..|.. ||.|||.| |. |
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldl
DDIRRLDRFKEPPAFGPMCDLLWSDPSEDfgneksqEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAP
. . .|.| . | | ..|| |.|| .. .. ... || . . .|| |||.. .| ..|||. || .. . |.||||||
kqldklkrpldipdvGvladltwadpdae.......vkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrk......lvtifsap
NYLDVYNNKAAVLKYENNV
.| .| ||||. ....
sycGqldniaavlsvdkkl
|
|||||||||
subfamily_Cele-PPP-2A_pd | Subfamily Cele-PPP-2A | 66-336 | 5.4e-51 | 166.6 | In-house | 22-281 (307) | alignment | ||
Range on Protein: 66-336
Range on HMM: 22-281/307.0
DEEIAlRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHL
||. .| | .|. ||...... | | ||.|||| ||...| . | | .| |.| ||||||| .|.||.| |.. || || . ||||||| ..
keefe.nviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarv
TEYFTFKQECKI---KYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEhfshntv
. ..| .|| | | .. .|. ||..||. . ||.|||||| . ||..| . | | . |.||.|| . |.
nkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkass.......
RGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSqttgfpSLITIFSAPNYLDVYNNKAAVLKYENN
|| . . . . . . |||||. || . |||||||| | ..|.| .||| ..
rgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgr......klitifsapmycnfyknagcvlkvdet
|
|||||||||
subfamily_Cele-PPP-3A_pd | Subfamily Cele-PPP-3A | 87-333 | 1.4e-50 | 165.4 | In-house | 2-242 (263) | alignment | ||
Range on Protein: 87-333
Range on HMM: 2-242/263.0
MIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS-ERVYE
..|..||| .||| |||. ||...|. |. ..|.||||||||||| .|.| .. |. ||. | ..||||||| . . . . |. | | .. | |||
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye
ACMEA----FDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPM-CDLLWSDPsedfgnEKSQEHFSHNTVRGCSYFYNYPAVCEFLQN
. . | .||.|..... ||.|||.|| ...||||| . | |. |||||.|| || . | | .| | . | .. .
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadp......ekdakgfepnkiraisnvfgkkevddlckr
NNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKY
.. |.|||. . || .. . |||.||| | | |||.
ldidlivrahqvveygyaffadrr......litvfsasryqielcnyaavvvv
|
|||||||||
subfamily_Cele-PPP-1B_pd | Subfamily Cele-PPP-1B | 120-336 | 3.6e-45 | 147.5 | In-house | 120-323 (339) | alignment | ||
Range on Protein: 120-336
Range on HMM: 120-323/339.0
TRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLD
|||||||||||| ||.| |. | ||. || ..||||||| | . . | .| . .| ..||. . |. .|..|..|. .|.|||.| . ...
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfn
DIRRLDRFKEPPAFGPMCDLLWSDPSEdfgNEKSqehfSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPN
.. . | | | | . || |.|| || . . ||.|. . ||. ||.. .| .|| |. . || .. . |.|||||||
qfsvfkrpleipdvgvltdltwadpdp...tekg....ykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrr......lvtifsapn
YLDVYNNKAAVLKYENN
| .| |||. ...
ycgqndntaavfsidkk
|
|||||||||
Metallophos | Calcineurin-like phosphoesterase | 93-293 | 1.5e-43 | 142.4 | Pfam-A | 2-199 (200) | alignment | ||
Range on Protein: 93-293
Range on HMM: 2-199/200.0
PITVCGDIHGQFFDL----MKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYL--WVLKILYPSTLFLLRGNHECRHLTEYFTFKQECK----------
.|.|.||.||.. || ..|....... .. .|||||.|||| |.|. .| .|||.|.| .||||||||........ |. |.
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange
------------------------IKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIrrldrfkeppafgpmcdllwsdpsedfgnek
.. ...|.. | |. |||.|| ....|..||.||.. . |||
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................
sqehfshntvrgCSYFYNYPAVCEFLQNNNLLSIIRAHEAQ
.|. ....|....|..... ..|.|. .
............gselfgpdalekllekygvdlvlrGHtHk
|
|||||||||
subfamily_PPP7C_pd | Subfamily PPP7C | 58-228 | 1.7e-33 | 108.9 | In-house | 26-203 (383) | alignment | ||
Range on Protein: 58-228
Range on HMM: 26-203/383.0
HLVKEGRVDEEIALRIINEGAAILRREKTMIEVEA----PITVCGDIHGQFFDLMKLFEVGGSPANT-RYLFLGDYVDRGYFSIECVLYLWVLKILYPST
.. .. .. . | |. | . .|.. . . .|.. .|||||.||.. ||. .. | |.. |.| ||.|||| |.| .| | .| ..||
afkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypke
LFLLRGNHECRHLTEYFTFKQECKIKY---SERVYEACMEAFDSLPLAALLNQQFLCVHGGLSpEIHTLDDIRRLDRFK
..| ||||| | . | .| . || .... . . | ||||.|.... | ||||.| .. |. . ...| |
vylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkiersk
|
|||||||||
subfamily_PPP7C_pd | Subfamily PPP7C | 236-338 | 2.6e-13 | 42.4 | In-house | 237-326 (383) | alignment | ||
Range on Protein: 236-338
Range on HMM: 237-326/383.0
MCDLLWSDPsedfgneKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYEN
. |.||||| |..| ||.|| .. ..||. || .||.|| . || . ... ..||||| || .. |. | .| .
vldilwsdp.......kakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkk......vltifsasnyyeeGsnrGayvklgk
NVM
...
dlt
|
|||||||||
subfamily_Cele-PPP-Subfam1_pd | Subfamily Cele-PPP-Subfam1 | 80-118 | 2.6e-10 | 33.0 | In-house | 24-62 (317) | alignment | ||
Range on Protein: 80-118
Range on HMM: 24-62/317.0
ILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPA
.. .|. ..|.|||.|..||||||| ||. |... | |
lfwkeplkleleapvtivGdihGqfedllalldlnGwpl
|
|||||||||
subfamily_YNL217W_pd | Subfamily YNL217W | 94-214 | 4.6e-07 | 22.5 | In-house | 12-139 (235) | alignment | ||
Range on Protein: 94-214
Range on HMM: 12-139/235.0
ITVCGDIHGQFFDLMKLFE--VGGSPANTRYLFLGDYVDRGYFSIECVLYLwvlkilYPSTLFLLRGNHECRHLTEYFTFKQECKI---------KYS-E
. | ||.|| . .|..|.. .|| | ...|| ...| |.| | |. . ..|||| | .| |.. . ..
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsfles
RVYEACMEAFDSLPLA-ALLNQQFLCVHGGLSPE
.. .| || .|. . . .. | ||.||.|
klskadmeyarelgfsldipsdellvvhaGlvpg
|
|||||||||
subfamily_Cele-PPP-1B_pd | Subfamily Cele-PPP-1B | 81-118 | 8.9e-07 | 21.3 | In-house | 27-64 (339) | alignment | ||
Range on Protein: 81-118
Range on HMM: 27-64/339.0
LRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPA
. | ....|||| | ||||||| ||. .... | |
iwsepiflkleapicvmgdihgqfddllamldmngwpl
|