Gene PPP3CB in Homo sapiens

Synonym: CALNA2, CALNB, CNA2, PP2Bbeta, RP11-345K20.1, PPP3CB

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP3C
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP139_AA protein Get Run
HsapP139_AA_91-294 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP3C_pd Subfamily PPP3C 25-495 8.4e-259 851.8 In-house 1-452 (452) alignment 
Range on Protein: 25-495
Range on HMM: 1-452/452.0
RVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLF
||||.||.|....||.||||| .|.|...|||.|..||||..|| ||.||.|.|..|..|||..||||||||.|||||||.||.|||||||.||.|.|||
rvvkkvplpkskklteeevfdetgkpklevlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylf

LGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRL
||||||||||||||||||. ||| ||||||||||||||||||||||||.||||||||.||.||||.|||||||||||||||||||||||||..||||..|
lGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkl

DRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVY
||||||||.||.|||||||| ||.|.||..|.|..|.||||||||.| |||||||.|.|||||||||||||||||||||..||||||||.||||||||||
drfkeppasGplcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvy

NNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQ-FDVGSAAARKEIIRNKIRAIGKMARVFSVL
||||||||||||||||||||.|||||||||||||||||||||||||||||||.|.|||||||..| |..  .  ....|||.||||||||||.|||||||
nnkaavlkyennvmnirqfnssphpywlpnfmdvftwslpfvgekvtemlvnilnicsddelekeeeeeskeesesekrkevirnkiraigklarvfsvl

REESESVLTLKGLTpTGMLPSGVLAGGRQTLqsatveaieaekairgfspPHRICSFEEAKGLDRINERMPP
||||||||.||||| ||.||.|.|..|...|                    ....||||||.||.|||..||
reesesvlllkglt.tgalprgalsegkegl...................eeklssfeeakkldlineklpp
0045823 Metallo-dependent phosphatases 24-495 4.6e-162 532.7 In-house 2-472 (473) alignment 
Range on Protein: 24-495
Range on HMM: 2-472/473.0
DRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYL
|||.| |..|....|| ...|.| |.. .|.|..||.|||.. || .|....| . ||..|....|....|.|.||||||..||..|.|  | | ..|..
drvlklvlipvlrlltlpllfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlv

FLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRR
||||.||||..|.|....|. |||.||.  ||||||||.|.|. .. |..|.  ||.|..||...| ..||||||......|.|||||||....||.||.
flGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqire

LDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDV
..|. |.| .|...||||||| ||.|.......| .|..||..|.....||.|||..|.|  |.|.|.... ||..... ...|....||.||||||...
ierpleipddgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgr

YNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMtEGEDQFDVGSAAARKEIIRNKIRAIGKMARVFSVL
..|.||||..........||..||||..||.|.|||..||||..||.||.|...|.|.|||||. | || ...    |..|..||||.|.||..||||||
ggnlaAvlvidedlisfiqfdpsphplilplfldvfllslpfllekltellllllnivsddell.ededilglllleallellrnkilalgkllrvfsvl

REESESVLTLKGLTPTGMLPSGVLAGGRQTLQSATVEAIEAEKAIRGFSPPHRICSFEEAKGLDRINERMPP
||||||||.||||||.|.|| |.|. |...|.....||....   . ..| . . |.||.| |..||||...
reesesvlllkgltpsgllplgllllgkelllesleealkldlineklppsllllsleeekslelinerles
PP2Ac_SM00156 67-338 1.2e-107 352.0 In-house 3-261 (271) alignment 
Range on Protein: 67-338
Range on HMM: 3-261/271.0
EEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLT
.| .|....| ..||..||...||.||.||.||||||. ||..|.| .| |....|.|||||||||..|||..|.|. ||||||....|||||||.....
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn

EYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPsedfgnEKSQEHFSHNTvRGCS
....|..|.|.||....|| ..|||..||||||.....||.|||||||...|||||.|.|.||.|  |...|||||||      |.....|.... ||.|
kiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdp......eqkekgfqpsk.rgls

YFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSqttgfpSLITIFSAPNYLDVYNNKAAVLKYENNVM
....  ||.|||..|||  ||||||..| ||... ..      .|.||||||||.| ..|||||||.|.|..
vvFgedavkeflkknnlkliiRahevvdeGyeffadk......klvtifsapnycdefsnkaavlkveknlk
PPP_1 67-331 1.6e-107 351.7 In-house 3-262 (264) alignment 
Range on Protein: 67-331
Range on HMM: 3-262/264.0
EEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLT
|| . ..... . .|..|....||...|||||||||||.||.|||.|||....|.|||||||||||..|.|..|.|..||. ||..|||||||||.|..|
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

EYFTFKQECK-IKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGC
....||.|..  |||...|......|| ||||||.....|.||||||||...||.||...|..| |. |..||||..| .... ..|.||.. .|..||.
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

SYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTtgfpslITIFSAPNYLDVYNNKAAVL
.|.... ....|||.||| .||||||....||....|...      .|||||.|| .. .|..|..
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkv......vtifsasnyyeegsnrgayv
0049330 Metallo-dependent phosphatases 47-352 9.9e-98 320.0 In-house 12-305 (309) alignment 
Range on Protein: 47-352
Range on HMM: 12-305/309.0
DGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLK
  .. .|.|...| |.....|| .|.....   ||. |....|....|.|.||||||..||..|.|  | | ..|..||||.||||..|.|..|.|. ||
lilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalk

ILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSE
.|||.  ||||||||.|.|. .. |..|.. ||.....|.... ..||||||......|||||||||....||.||.|.|. |.|..|..||||||||..
llypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplp

DFGNeksqehFSHNTvRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENN-VMNIRQFNC
.. .      | .|. ||....... ||..||. |.|  |||.|.|.. ||... . .      |||.||||||.....|..|||..... |.....|..
ireg......fapnp.rglgvvfghtaverflkkngldliirghgavfgGyltffdgk......litvfsapnycgrlgnlgavleidedlvisfllfep

SPHPYWL
.|....|
vplllll
PPP_3 66-338 4.1e-96 314.1 In-house 3-263 (271) alignment 
Range on Protein: 66-338
Range on HMM: 3-263/271.0
DEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHL
.|. . ..... . ||  |....|..||.|||||||||. ||..||..||....|.|||||||||||..|.|..|.|..|||.||....|||||||.|..
senelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqi

TEYFTFKQECK-IKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSedfgnekSQEHFSHNTVRG
.....||.|..  |....||....| |. ||||||.....|.|||||||.|..||.|..|.|..| |  |...|||.|...       ..|.. .|..||
nkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdp.......ekeeglenskrG

CSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKsqttgfPSLITIFSAPNYLDVYNNKAAVLKYENNVM
.....   ...|||..|.|  ||||||....||.....       ...|.||||||.. ..|..|.|| |.. .
agllFgpdvteefleknkLkliiRaHelkeeGyeilhd......gkvvtvfSapnycerasnagailkleealt
0053225 Metallo-dependent phosphatases 51-344 4e-91 298.4 In-house 8-289 (293) alignment 
Range on Protein: 51-344
Range on HMM: 8-289/293.0
RVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYP
 .|.|...|..  ...|| .|....|   ||..|....|....|.|.|||||...||..|.|  | | ..|..||||.||||..|.|....|. ||.|||
lldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllyp

STLFLLRGNHECRHLTEYFTFKQECKIKY-SERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFG
.  .|||||||...|. .. |..|.. || .......... ..|||||||.....|.|||||||....||.||...|. ..| .|...|||||||.. .|
dnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsg

NEKSQehfshntvRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKsqttgfPSLITIFSAPNYLDVYNNKAAVLKYENN-VMNIRQFN
  .|.        ||....... ||..||..|.|  |||.|.... ||... .      ..|.|.|||||||....|..|||..... |... .|.
wlpsy........rglgvvfghtavlrflkkngldliirghqvvpdgylpwfd......gklvtvfsapnylgrlgnlgavlaldeglvwgfklfa
subfamily_PPP1C_pd Subfamily PPP1C 68-338 6.2e-87 284.4 In-house 13-270 (282) alignment 
Range on Protein: 68-338
Range on HMM: 13-270/282.0
EIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTE
.   .....  .|| .. ...|.|||....||||||. ||..||| .|.|....||||||||||| .|.| .. | ..|| ||..|||||||||. ....
aeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasinr

YFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDfgneksQEHFSHNTvRGCSY
.. |. ||| .|| ..... ...|. ||||||.... ||||||||||.. |..||.. |  | |  | .|||||||| ..      .. .|.|. || |.
iyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdke......vlgwsend.rGvsf

FYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
 ..  .| .|||.|.|  |.|||.  ..||... | |      |.|.||||||.. ..|..|||. .....
tfgkdvvekflqkndldlivrahqvvedGyeffakrq......lvtvfsapnycgefdnagavlsvdeell
subfamily_PPP4C_pd Subfamily PPP4C 65-338 1.6e-83 273.3 In-house 16-276 (288) alignment 
Range on Protein: 65-338
Range on HMM: 16-276/288.0
VDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRH
. ||   .. ..   ||  |  . .|..|.||||||||||.||..||.|||.  .|.||||||.||||..|.|. | | .||. ||  . |.|||||.|.
ikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrq

LTEYFTFKQECKIKY-SERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSqehfshntVR
.|. . | .||  || | .|.. |.| || |.|||..... .||||||||.|.|||.|| .|| .| |  ||.|||||||| .  |   |         |
itqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaegwavs........pr

GCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
|  |..   .| .| ..|..  |.|||.    ||... . .      ..|..|||||     |.||.|...... 
gagylfgsdvveqfneandielicrahqlvmegyklhfnek......vltvwsapnycyrcgnvaaileldeeld
subfamily_PPP5C_pd Subfamily PPP5C 57-351 4e-82 268.8 In-house 26-314 (322) alignment 
Range on Protein: 57-351
Range on HMM: 26-314/322.0
NHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAP----ITVCGDIHGQFFDLMKLFEVGGSPANT-RYLFLGDYVDRGYFSIECVLYLWVLKILYPS
... |. .. . .||.|. |  ..|... ...|.. .    .||||||||||.||. .||. |.|...  ||| ||.|||| ||.|..| |. .|.||| 
elfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPn

TLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLS-PEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGN
 .|| |||||  .. . . |..|.| ||.|.|..   | |..|||| ..|...| |||||   .  ||||.|..||...||  | ...|||||| |  | 
hfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGr

EKSQehfshntvRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKY--ENNVMNIRQFNCSPH
 .|.        || .  .      .||..|||  |||.|| .. ||.. .. .      |||.|||||| |  .||.|...   ... .....|.  .|
spsk........rGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGk......litvfsapnycdqmgnkgafitlrgddlklkfktfeaveh

PYW
|  
pdv
subfamily_PPP2C_pd Subfamily PPP2C 53-347 2.9e-81 265.9 In-house 5-287 (290) alignment 
Range on Protein: 53-347
Range on HMM: 5-287/290.0
DVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPST
| | ..| .  ...|.   .....   ||..|. . ||..|.|||||.||||.||..|| .||.  .| ||||||||||||.|.|.| .| .||. |.. 
dklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvryker

LFLLRGNHECRHLTEYFTFKQECKIKYSE-RVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNE
. .|||||| | .|. . | .||  ||..  |..   . || |||.||...| .|.||||||.|.|||.|| |||..| |  ||.|||||||| .  |  
itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrggwg

KSQehfshntvRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQFNCSP
 |.        ||. | .      .| ..|.|  |.|||.    ||..  . .      ..||||||||     |.||.|. .... ... ||. .|
isp........rgagytfgkdisekfnktngltliarahqlvmegynwshdrn......vvtifsapnycyrcgnqaailelddklkysflqfdpap
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 65-338 8.9e-78 254.3 In-house 24-285 (298) alignment 
Range on Protein: 65-338
Range on HMM: 24-285/298.0
VDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRH
..||   ..|..   |... |...||.|||.||||||||. ||..||. .| | .. ||||||||||| ...| .. | . |. ||. .||||||||| .
ikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnhecea

LTEYFTFKQECKIKY-SERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPsedfgnEKSQEHFSHNTvR
. . . |..||| .| | |.|..  ..|..|||.||. .. ||.|||||.....||..|.| | ....      ||||.||      |.... ...|. |
inrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadp......enavkgwaens.r

GCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
| |. .   .| ..|.. ..  ..|||     || .. . .      |.||||||.|.. ..| |||.| .....
GvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekk......lvtifsaphycgqfdnsaavmkvdeklv
subfamily_PPG1_pd Subfamily PPG1 75-336 1.4e-74 244.0 In-house 24-285 (300) alignment 
Range on Protein: 75-336
Range on HMM: 24-285/300.0
NEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQE
.    .| .|  .||...|.|| ||.||||.|....|..||   .| |||||||||||..|.| .  | |||. ||| . ||||||| | .|. . |  |
dklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyte

CKIKY--SERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFG-----NEKSQEHFShNTVRGCSY
|  ||    ||..   | || | |||.....  ||||||||.. ..|.|. ||||.| |  | ..||||||| |.        ... .||  .. ||. |
clrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfv.vsqrgagy

FYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTgfpsliTIFSAPNYLDVYNNKAAVLKYENN
 |    | .||.||..  |||||.    ||...  .. .      |..|||||     |||..|. ...
sygkdvvekflrnndmnriirahqlcnegyqilfdnkls......tvwsapnycyrcgnkasilelyek
subfamily_PPP6C_pd Subfamily PPP6C 72-343 8.2e-74 241.3 In-house 22-281 (290) alignment 
Range on Protein: 72-343
Range on HMM: 22-281/290.0
RIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTF
.. .  . .| .| ..  |..|.||||||||||.||..||  ||.  .|.|.||||.|||||.|.| . .| .||. ||. . |||||||.|..|. . |
klcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygf

KQECKIKYSE-RVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPsEDFgneksqEHFsHNTVRGCSYFYN
 .||. || .  ..  |.. || |..||....| |||||||||...|||.|| ..| .| |  |..|||.|||| ||       |.. . . ||  |.. 
ydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edv......etw.avsprgagylfg

YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQF
   . ||...|||  |.|||.  . |.. . . .      |.|..|||||     | |..|. |..   . . |
skvtkefvhinnlklicrahqlveeglkymfdek......lvtvwsapnycyrcgnvasilaledaeereaklf
PPP_4 94-293 1.7e-73 239.9 In-house 1-197 (197) alignment 
Range on Protein: 94-293
Range on HMM: 1-197/197.0
ITVCGDIHGQFFDL-MKLFEVGGSPA-NTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAF
.||.||||||..|| .||...|| |. ...|.|||||||||..|.|..|.|. ||. ||....|||||||...|.....||.|.. |........... |
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

DSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPP-AFGPMCDL-LWSDPSedfgneKSQEHfSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRA
| ||||||.....|.||||||.|...||.|.|..|..| |   . ..|| |||||.      ..||. ..|.|||..... . ....||..||| .|||.
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpr......eaqeg.lansvrGagllFgpdvtekfleknnlkliirs

HEAQ
||..
helk
PPP_2 94-292 3e-73 238.7 In-house 1-197 (198) alignment 
Range on Protein: 94-292
Range on HMM: 1-197/198.0
ITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECK-IKYSERVYEACMEAFD
.|||||.|||. ||..||..|.......|||||||||||..|.|..|.|..||. ||....|||||||.........||.|..  |....||....| |.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

SLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLwsdPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEA
 ||||||.....|.||||||.||..||.|.. .|..| |. |...|||   ..|.. ..|..|.. .|..||......  ...|.|..|.|  ||||||.
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldll...eeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_5_Dcr2 94-292 1.4e-69 227.1 In-house 1-198 (199) alignment 
Range on Protein: 94-292
Range on HMM: 1-198/199.0
ITVCGDIHGQFFDL-MKLFEVGGSPA-NTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIK-YSERVYEACMEA
.|||||.|||..|| ..||. || |. ...|.|||||||||..|.|..|.|. ||..||....|||||||...|.|...|..|.. | .....|... . 
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPP-AFGPMCDL-LWSDPSedfgneKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIR
|| ||||||.....|.|||||||||..........|..| |   | ..|| |||||.      ..||.   |..||....... ....||..|||  |||
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdpr......daqegcklnseRGagllfgpdvtekfleknnlkliir

AHEA
.||.
shel
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 71-336 4e-69 225.8 In-house 12-264 (280) alignment 
Range on Protein: 71-336
Range on HMM: 12-264/280.0
LRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFT
 |.|..   ||  ..||.||.||..||||.|||. ||..||.  . | .. ||||||||||| . .| .| |   |. || ....||||||. .. . . 
drviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkyg

FKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNeksqehFSHNtVRGCSYFYN
||.|.| .||. .|.   | .|||||.||.. . ||.|||||... .|||...| |  ...      ||||.||...         ...|  ||.|. . 
fkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtg......waen.srgvsvifg

YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENN
   | .. .  ..  |.| |.  . || .. . .      |.|.||||.||. ..|.||||. ...
anvvkdltekldidliarghqvvqdgyeffadkk......lvtvfsapkylgefdnsaavlivder
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 60-335 8e-69 224.7 In-house 6-270 (287) alignment 
Range on Protein: 60-335
Range on HMM: 6-270/287.0
VKEGRVDEEIaLRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGN
| ..  |..| | ....   ||.  ....|||||||..||||||. ||...|.  | .....|||||||||||  |.| .|.|. |||.||  . |||||
vldafsdkdi.levlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGn

HECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAF--GPMCDLLWSDPSEDfgneksQEHF
||.... . . ||.| | |..||.|.   . |. ||| | .... ||.|||.||....||... | . . | |   | . ||||.||..|      .. |
hevkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd......aktf

SHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYEN
  | .|. |  .    | ..|.. ..  |.|||| .. || .. . .      |.|.|||| |     | .||.. ..
elnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkr......lvtvfsapyysgedtnlgavvvvsk
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 67-337 1.2e-66 217.8 In-house 11-267 (281) alignment 
Range on Protein: 67-337
Range on HMM: 11-267/281.0
EEIaLRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLT
|||   .| |  ||.  ||...|...||.| ||.|.|| || .|||. | .......|||||||||  |.|... |..||| |.  ..|||||||  .. 
eei.envireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvn

EYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEdfgneKSQEHFsHnTVRGCS
  . | .||. || | ..    . |. ||..|| ... ||.|||||||. .||..|   .  ...  | . ||||.||..     |..| . . ..|| |
kiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdn.....kveewk.a.ssrGss

YFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
. .    | .  .. ..  |||||    .||..    .      |||.||.||| . |.| ||||| ....
ftfGknvvddvckrleveliirahqvvqdGyevlsgrk......litvfsvpnycafyknaaavlkvdetl
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 80-338 8.2e-66 215.3 In-house 23-274 (284) alignment 
Range on Protein: 80-338
Range on HMM: 23-274/284.0
ILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSP------ANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQ
.. .||  .|.|||....||||||| ||. |... | |       ...||||||||||| |||| .. |. .|.|.|  .|||||||| | .   . | .
lfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyl

ECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFgneksqEHFsHNTVRGCSYFYNYPA
||| .|||..|||   || ..||.|..... .|.|||.| ..  |... .|.|  . |  | ..|| |.||...       |.. ... ||.   .   |
eckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaev......egy.kesprgagkvfgaka

VCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
| |||.. .|  ..|||.    || ..   .      |.|||||| |   ..| ||||. .....
vkeflkkfkldlvvrahqvvmdgyeffadrk......lvtifsapsycgqldniaavlnvdeelv
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 78-338 2e-65 214.0 In-house 37-285 (299) alignment 
Range on Protein: 78-338
Range on HMM: 37-285/299.0
AAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKI
  ..  . ...|||||| ||||||||. ||...|.. | | .. .||||||||||   .| .  | . || ||  .|.|||||||  .   . | .||. 
ksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecnk

KY-SERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEdfgnekSQEHFSHNtVRGCSYFYNYPAVCE
.| | |.. .  .||. .||. |.. . ||.||||||...||| .| | | ..||.     ||||.|| .      |   .  | ||| || .    | .
rykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdq......svkdwlan.vrgvsyvfgqdvvad

FLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
 ... ..  . |||.  . || .. . .      |.|||||| |   ..| ||..| ..|..
visrldidlvarahqvvqdgyeffaskk......lvtifsaphycgqfdnsaaimkvdenlv
subfamily_PPZ_pd Subfamily PPZ 70-335 7.7e-64 209.1 In-house 30-282 (300) alignment 
Range on Protein: 70-335
Range on HMM: 30-282/300.0
ALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYF
 |.|  .   ..  . ...|.  .. . ||.|||. ||..||   | |  . |||||||||||  |.| .| |.. || ||  .|||||||||  .|  .
ilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrvy

TFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSeDFGNEksqehFSHNtVRGCSYFY
 | .||| .   ..... ...|..|||||..  . .|||||||| . ..|.||.. |  . | || . |||||||. |  ||     .  |  || || |
gfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdpt.dssne.....wedn.ergvsycy

NYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSqttgfpSLITIFSAPNYLDVYNNKAAVLKYEN
|  |. .||..  .  . |||   . || ..         ||.|.||||||   ..|  ||.   .
nkvainkflnkfgfdlvcrahmvvedgyeffndr......slvtvfsapnycgefdnwgavmsvse
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 65-335 2.5e-62 203.8 In-house 23-283 (297) alignment 
Range on Protein: 65-335
Range on HMM: 23-283/297.0
VDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRH
. ||  |....    .....|.|.||.||| ||||||||| ||..||  || |  . ||||||||||| |||| .. |   |. .|. ||||||||||  
iteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecef

LTEYFTFKQECKIKY-SERVYEACMEAFDSLPLAALLNQQFLCVHGGLSP---EIHTLDDIRRLDRFKEPpAFGPMCDLLWSDPSEDFGNeksqehFSHN
. . . | .||. .| | |.| |  . |. |||. |. .. ||.||||||   .  ||| .|...| .|    . ..||||.||   .        | .|
vnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsg......fmen

TvRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYEN
  ||.   .   || .   . .|  . |||.  . || ..   .      |.|||||| |   ..| ||..  ..
q.rgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrk......lvtifsaphycgqfdncaafmscde
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 71-337 1.3e-60 198.1 In-house 12-290 (302) alignment 
Range on Protein: 71-337
Range on HMM: 12-290/302.0
LRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGG-----------SPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGN
| .|..  . |..|||..|. .|.|. ||||||| ||....               | .. ...|||||||||. ||||.  .. ||.|||.   |||||
lllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgn

HECRHLTEYFTFKQECKIKYSE----RVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAF-GPMCDLLWSDPSEDF--GNEK
||.. .   ..|..| ......    ...|   |.|  .|||||. .. ||||||.|| ...|.||....|  .  .      |||..|| .       .
hetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaavs

SQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
.. .. .|.||| |. .|  || .. .. ||  |.|||    .|.... . .      |.||||||.|..  .|| |||| . | 
ekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 71-337 2.1e-60 197.5 In-house 13-291 (302) alignment 
Range on Protein: 71-337
Range on HMM: 13-291/302.0
LRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGG-----------SPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGN
| .|..  . |..|||..|. .|.|. ||||||| ||....               | .. ...|||||||||. ||||.  .. ||.|||.   |||||
lllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgn

HECRHLTEYFTFKQECKIKYSE----RVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAF-GPMCDLLWSDPSEDF--GNEK
||.. .   ..|..| ......    ...|   |.|  .|||||. .. ||||||.|| ...|.||....|  .  .      |||..|| .       .
hetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaavs

SQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
.. .. .|.||| |. .|  || .. .. ||  |.|||    .|.... . .      |.||||||.|..  .|| |||| . | 
ekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 55-333 5.9e-59 192.4 In-house 7-275 (290) alignment 
Range on Protein: 55-333
Range on HMM: 7-275/290.0
LKNHLVKEGRVDEEIaLRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLF
|. . | ..  |..| | |...   ||.   ...||||||.. ||||||. .|.. |.  | | . ..||||||||||  |.|  |.|. .||.|. .. 
llkygvldafsdkdi.leilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvh

LLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPP--AFGPMCDLLWSDPSEDfgnek
|||||||.|..   . ||.|   | . |..    . |. |.| | .... ||.|||.|..|.. . .. | . . |     | . ||||.||..|     
llrgnhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrd.....

SQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKY
 .. .. |  |. |  .   .. ..|..  |  |.|||| .. |. .  . .      |.|.|||| |     |  |... 
kddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkk......lvtvfsapyysgndtnlgaiatv
subfamily_PPPLV_pd Subfamily PPPLV 73-338 5e-58 189.7 In-house 5-281 (290) alignment 
Range on Protein: 73-338
Range on HMM: 5-281/290.0
IINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLM----KLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEY
. .    ||  |. ..|...|. | ||.||.. ||.    .|. .|   . . .|||||||||| ||.| . ||  ||.|||| ..||||||| . ..| 
lcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqes

FTFKQECKIKYSE---RVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRR----LDRFKEPPAFGPMC-DLLWSDPSEDF-----GNEKSQE
...| |.. |. .    |.|| ...|| ||||| .... .|||.|.   |.|   |      |.|.|..    |.  |.|||||.||      |.   .|
ieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlne

HFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
 | .|  || .. .   |.  ||..|||  ..||||....|.|. .|..      |.|.||. .|    |. | .|  .... 
GfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgr......lltvfsssrycGssneaalilvdkkklr
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 74-337 6.1e-58 189.5 In-house 12-264 (284) alignment 
Range on Protein: 74-337
Range on HMM: 12-264/284.0
INEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQ
. .  .|. ..  .|||..|| .|||||||| ||..||.  | |  . |||||||||||   .| .| |.  |...|  .|.|||||||  . . . | .
lfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfye

ECKIKYSE-RVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDR-FKEPPAFGPMCDLLWSDPSEdFgneksQEHFSHNTvRGCSYFYNY
||. .| .  || .    |  .||.||. |. ||.|||.|  .. . ..| . | | .|       |.|||||.. |     |. .  |. || || .  
ecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptn.f.....qkgwnpns.rgvsyvfgs

PAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
 |. ..|.  ..  ..|||.  . || .. . .      |.|||||| |   ..| |||.  ..|.
dalrklldrlqidlvvrahqvvqdgyeffanrr......lvtifsapfycgqfdnaaavmyvnknl
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 71-343 7.8e-57 185.8 In-house 12-272 (280) alignment 
Range on Protein: 71-343
Range on HMM: 12-272/280.0
LRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFT
. ||    ||.  |  ..| |||| | |||| |. |. .||.. |   . . .|||||||||   || .. |..||| |   ..|||||||   . . . 
iaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiyg

FKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEdfgneKSQEHFsHnTVRGCSYFYN
|  ||. ||   ..     .|. .|...|.... ||.|||||||.  || || . |  ||   | . |||||||..     | .  | | ..|| ||.. 
fyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptn.....kgegwf.h.sirgisymfg

YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYrksqtTGfPSLITIFSAPNYLDVYNNKAAVLKYENNVM-NIRQF
   | .  .. ..  |||||.  . || |      .|   |||.|| |||   . | |||.  . |.  ...|.
kgvveqacksleidliirahqvvqdgyemm.....ag.rrlitvfsvpnycaqftnaaavvclnanlqvsfqql
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 119-337 1.8e-56 184.6 In-house 100-305 (317) alignment 
Range on Protein: 119-337
Range on HMM: 100-305/317.0
NTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTL
. .||||||||||| |||| |. |  ||.|||  .|||||||| | .   . | .|.| .||...|||   ||  |||.|..|.. ||.|||.| |.  |
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldl

DDIRRLDRFKEPPAFGPMCDLLWSDPSEDfgneksqEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAP
. . .|.|  . |  | ..|| |.|| ..       ..  ... || .  .  .|| |||.. .|  ..|||.    || ..   .      |.||||||
kqldklkrpldipdvGvladltwadpdae.......vkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrk......lvtifsap

NYLDVYNNKAAVLKYENNV
.|    .| ||||. ....
sycGqldniaavlsvdkkl
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 66-336 5.4e-51 166.6 In-house 22-281 (307) alignment 
Range on Protein: 66-336
Range on HMM: 22-281/307.0
DEEIAlRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHL
 ||.   .| |  .|.  ||...... |  | ||.|||| ||...| . | | .| |.| ||||||| .|.||.| |.. || ||  . |||||||  ..
keefe.nviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarv

TEYFTFKQECKI---KYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEhfshntv
 . ..| .||     |  | ..     .|. ||..||.  . ||.|||||| .  ||..|   .    |  | . |.||.||     . |.         
nkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkass.......

RGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSqttgfpSLITIFSAPNYLDVYNNKAAVLKYENN
||  . .    . .  .   .  |||||.    || .           |||||||| | ..|.|  .||| .. 
rgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgr......klitifsapmycnfyknagcvlkvdet
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 87-333 1.4e-50 165.4 In-house 2-242 (263) alignment 
Range on Protein: 87-333
Range on HMM: 2-242/263.0
MIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS-ERVYE
..|..||| .||| |||. ||...|.  |. ..|.||||||||||| .|.| .. |. ||.  |  ..||||||| . . . . |. | | ..  | |||
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

ACMEA----FDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPM-CDLLWSDPsedfgnEKSQEHFSHNTVRGCSYFYNYPAVCEFLQN
.  .     |  .||.|..... ||.|||.|| ...||||| .    |     |. |||||.||      ||  . |  | .|  |  .    | .. . 
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadp......ekdakgfepnkiraisnvfgkkevddlckr

NNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKY
 ..  |.|||.  . || ..   .      |||.|||  |     | |||.  
ldidlivrahqvveygyaffadrr......litvfsasryqielcnyaavvvv
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 120-336 3.6e-45 147.5 In-house 120-323 (339) alignment 
Range on Protein: 120-336
Range on HMM: 120-323/339.0
TRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLD
 |||||||||||| ||.| |. |  ||. ||  ..||||||| | .   . | .| . .|  ..||.  . |. .|..|..|.  .|.|||.|  . ...
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

DIRRLDRFKEPPAFGPMCDLLWSDPSEdfgNEKSqehfSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPN
..  . |  | |  | . || |.||      ||      . . ||.|. .  ||.  ||.. .|  .|| |.  . || ..   .      |.|||||||
qfsvfkrpleipdvgvltdltwadpdp...tekg....ykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrr......lvtifsapn

YLDVYNNKAAVLKYENN
|    .| |||.  ...
ycgqndntaavfsidkk
Metallophos Calcineurin-like phosphoesterase 93-293 1.5e-43 142.4 Pfam-A 2-199 (200) alignment 
Range on Protein: 93-293
Range on HMM: 2-199/200.0
PITVCGDIHGQFFDL----MKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYL--WVLKILYPSTLFLLRGNHECRHLTEYFTFKQECK----------
.|.|.||.||.. ||    ..|....... .. .|||||.||||  |.|.  .|  .|||.|.|  .||||||||........ |. |.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------IKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIrrldrfkeppafgpmcdllwsdpsedfgnek
                         ..  ...|.. | |. |||.|| ....|..||.||..  . |||                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sqehfshntvrgCSYFYNYPAVCEFLQNNNLLSIIRAHEAQ
            .|. ....|....|.....  ..|.|. .
............gselfgpdalekllekygvdlvlrGHtHk
subfamily_PPP7C_pd Subfamily PPP7C 58-228 1.7e-33 108.9 In-house 26-203 (383) alignment 
Range on Protein: 58-228
Range on HMM: 26-203/383.0
HLVKEGRVDEEIALRIINEGAAILRREKTMIEVEA----PITVCGDIHGQFFDLMKLFEVGGSPANT-RYLFLGDYVDRGYFSIECVLYLWVLKILYPST
.. .. ..  .  | |. | . .|.. . . .|..     .|||||.||.. ||. ..   | |..   |.| ||.||||  |.| .| | .| ..||  
afkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypke

LFLLRGNHECRHLTEYFTFKQECKIKY---SERVYEACMEAFDSLPLAALLNQQFLCVHGGLSpEIHTLDDIRRLDRFK
..| |||||   |   . | .| . ||   .... .   . |  ||||.|.... | ||||.| ..  |. . ...| |
vylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkiersk
subfamily_PPP7C_pd Subfamily PPP7C 236-338 2.6e-13 42.4 In-house 237-326 (383) alignment 
Range on Protein: 236-338
Range on HMM: 237-326/383.0
MCDLLWSDPsedfgneKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQttgfpsLITIFSAPNYLDVYNNKAAVLKYEN
. |.|||||       |..|    ||.||   ..      ..||. ||  .||.|| .  || .  ...      ..||||| || ..  |. | .|  .
vldilwsdp.......kakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkk......vltifsasnyyeeGsnrGayvklgk

NVM
...
dlt
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 80-118 2.6e-10 33.0 In-house 24-62 (317) alignment 
Range on Protein: 80-118
Range on HMM: 24-62/317.0
ILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPA
.. .|. ..|.|||.|..||||||| ||. |... | | 
lfwkeplkleleapvtivGdihGqfedllalldlnGwpl
subfamily_YNL217W_pd Subfamily YNL217W 94-214 4.6e-07 22.5 In-house 12-139 (235) alignment 
Range on Protein: 94-214
Range on HMM: 12-139/235.0
ITVCGDIHGQFFDLMKLFE--VGGSPANTRYLFLGDYVDRGYFSIECVLYLwvlkilYPSTLFLLRGNHECRHLTEYFTFKQECKI---------KYS-E
. | ||.|| . .|..|..  .||   |   ...|| ...|  |.| | |.        .    ..||||   | .|   |..  .         ..   
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsfles

RVYEACMEAFDSLPLA-ALLNQQFLCVHGGLSPE
.. .| ||   .|. .  .  .. | ||.||.| 
klskadmeyarelgfsldipsdellvvhaGlvpg
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 81-118 8.9e-07 21.3 In-house 27-64 (339) alignment 
Range on Protein: 81-118
Range on HMM: 27-64/339.0
LRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPA
.  |  ....|||| | ||||||| ||. .... | | 
iwsepiflkleapicvmgdihgqfddllamldmngwpl