Gene PPP3CC in Homo sapiens

Synonym: CALNA3, CNA3, PP2Bgamma, PPP3CC

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP3C
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP140_AA protein Get Run
HsapP140_AA_78-281 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP3C_pd Subfamily PPP3C 13-488 1.4e-256 844.5 In-house 1-452 (452) alignment 
Range on Protein: 13-488
Range on HMM: 1-452/452.0
RVIKAVPFPPTQRLTFKEVFEN-GKPKVDVLKNHLVKEGRLEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLF
||.|.||.|....|| .|||.. ||||..|||.|..||||||||.|||||...|..|..|||..||.|||||.|||||||.||.|||||||.|..|.|||
rvvkkvplpkskklteeevfdetgkpklevlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylf

LGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKL
||||||||||||||||||..|||..|.|||||||||||||||.|||||.||.|||||.|||||||.||.|||||||||||||||||.||||.|||||.||
lGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkl

DRFTEPPAFGPVCDLLWSDPSEDYGNEKTLEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVY
||| ||||.||.|||||||| ||||.||| |....|.|||||||||| |||||||.|.|||||||||||||||||||||.|||||||||.||||||||||
drfkeppasGplcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvy

NNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELISDDEAEdhyipSYQKGSTTVRKEIIRNKIRAIGKMAR
||||||||||||||||||||.|||||||||||||||||||||||||||||||.||||||||| ...|.|     | .. ....|||.||||||||||.||
nnkaavlkyennvmnirqfnssphpywlpnfmdvftwslpfvgekvtemlvnilnicsddelekeeeee.....skeesesekrkevirnkiraigklar

VFSILRQESESVLTLKGLTpTGTLPLGVLSGGKQTIetatveaveareairgfslQHKIRSFEEARGLDRINERMPP
|||.||.||||||.||||| ||.|| |.||.||...                   ..|..|||||..||.|||..||
vfsvlreesesvlllkglt.tgalprgalsegkegl...................eeklssfeeakkldlineklpp
0045823 Metallo-dependent phosphatases 12-488 1.4e-156 514.7 In-house 2-472 (473) alignment 
Range on Protein: 12-488
Range on HMM: 2-472/473.0
DRVIKAVPFPPTQRLTFKEVF-ENGKPKVDVLKNHLVKEGRLEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYL
|||.| |..|....|| ...| ..|.. .|.|..||.|||.|.||..||.... . ||..|....|....|.|.||||||..||..|.|  | |...|..
drvlklvlipvlrlltlpllfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlv

FLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRK
||||.||||..|.|....|..|||..|.  ||||||||.|.|. .. |..|.. ||.|..|....| ...|||||......|.|||| ||....||.||.
flGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqire

LDRFTEPPAFGPVCDLLWSDPSEDYGNEKTLEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDV
..|. |.| .|...||||||| || |.... ... .|..||..|.....||.|||..|.|  |.|.|.... ||..... ...|....||.||||||...
ierpleipddgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgr

YNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELISDDEAEdhyipsyQKGSTTVRKEIIRNKIRAIGKMA
..|.||||..........||..||||..||.|.|||..||||..||.||.|...|||.||||| .|..         ..  .....|..||||.|.||..
ggnlaAvlvidedlisfiqfdpsphplilplfldvfllslpfllekltellllllnivsddellededil.......glllleallellrnkilalgkll

RVFSILRQESESVLTLKGLTPTGTLPLGVLSGGKQTIETATVEAVEAREAIRGFSLQHKIRSFEEARGLDRINERMPP
||||.||.||||||.||||||.|.||||.|. ||... ....||....   . .. .....|.||.. |..||||...
rvfsvlreesesvlllkgltpsgllplgllllgkelllesleealkldlineklppsllllsleeekslelinerles
PPP_1 53-319 6.5e-106 346.4 In-house 2-263 (264) alignment 
Range on Protein: 53-319
Range on HMM: 2-263/264.0
EEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHL
|||.. ....  . .|..|....||...|||||||||||.||.|||.|||....|.|||||||||||..|.|..|.|..||...||.|||||||||.|..
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TDYFTFKQECR-IKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGNEKTLEHYTHNTVRG
|....||.|..  |||...|......||.||||||.....|.||||.|||...||.|||..|.|| |. |..||||..| .... ..|. |. ..|..||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

CSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLK
..|.... ....|||.||| .||||||....||....|..      ..|||||.|| .. .|..|..|
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrk......vvtifsasnyyeegsnrgayvk
PP2Ac_SM00156 53-325 6e-105 343.1 In-house 2-261 (271) alignment 
Range on Protein: 53-325
Range on HMM: 2-261/271.0
EEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHL
..| .|..... ..||.|||...||.||.||.||||||. ||..|.| .| |....|.|||||||||..|||..|.|..||| .|....|||||||....
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPsedygnEKTLEHYTHNTvRGC
. ...|..|...||....|. ..|.|..||||||.....||.|||.|||..||||||||.|. |.|  |...|||||||      |.. ....... ||.
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdp......eqkekgfqpsk.rgl

SYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSqatgfpSLITIFSAPNYLDVYNNKAAVLKYENNVM
|....  ||.|||..|||  ||||||..| ||... ..      .|.||||||||.| ..|||||||.|.|..
svvFgedavkeflkknnlkliiRahevvdeGyeffadk......klvtifsapnycdefsnkaavlkveknlk
0049330 Metallo-dependent phosphatases 36-339 1.9e-97 319.0 In-house 14-305 (309) alignment 
Range on Protein: 36-339
Range on HMM: 14-305/309.0
KPKVDVLKNHLVKEGRLEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKIN
.. .|.|...| |...|.||..|....    ||..|....|....|.|.||||||..||..|.|  | |...|..||||.||||..|.|..|.|..||. 
lslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkll

HPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDY
.|.  ||||||||.|.|. .. |..|.  ||..............|||||......|||||| ||....||.||.|.|..|.|..|..||||||||....
ypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpir

GNektlehYTHNTvRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENN-VMNIRQFNCSP
 .      ...|. ||..... . ||..||. |.|  |||.|.|.. ||... . .      |||.||||||.....|..|||..... |.....|...|
eg......fapnp.rglgvvfghtaverflkkngldliirghgavfgGyltffdgk......litvfsapnycgrlgnlgavleidedlvisfllfepvp

HPYWL
....|
lllll
PPP_3 52-325 2.5e-95 311.6 In-house 2-263 (271) alignment 
Range on Protein: 52-325
Range on HMM: 2-263/271.0
LEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRH
|.|... ....  . || .|....|..||.|||||||||. ||..||..||....|.|||||||||||..|.|..|.|..|||..||...|||||||.|.
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

LTDYFTFKQECR-IKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDygnektlEHYTHNTVR
......||.|.   |....||....|.|..||||||.....|.||||.||.|.|||.|.||.|..| |  |...|||.|...|.       |. ..|..|
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpek.......eeglenskr

GCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKsqatgfPSLITIFSAPNYLDVYNNKAAVLKYENNVM
|......  ...|||..|.|  ||||||....||.....       ...|.||||||.. ..|..|.|| |.. .
GagllFgpdvteefleknkLkliiRaHelkeeGyeilhd......gkvvtvfSapnycerasnagailkleealt
0053225 Metallo-dependent phosphatases 38-331 1.2e-90 296.9 In-house 8-289 (293) alignment 
Range on Protein: 38-331
Range on HMM: 8-289/293.0
KVDVLKNHLVKEGRLEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHP
 .|.|...|..  .| ||..|....    ||..|....|....|.|.|||||...||..|.|  | |...|..||||.||||..|.|....|..||. .|
lldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllyp

KTLFLLRGNHECRHLTDYFTFKQECRIKY-SEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYG
.  .|||||||...|. .. |..|.  || .....|........||||||.....|.|||| ||....||.||...|....| .|...|||||||.. .|
dnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsg

NEKTLehythntvRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKsqatgfPSLITIFSAPNYLDVYNNKAAVLKYENN-VMNIRQFN
  .          ||..... . ||..||..|.|  |||.|.... ||... .      ..|.|.|||||||....|..|||..... |... .|.
wlpsy........rglgvvfghtavlrflkkngldliirghqvvpdgylpwfd......gklvtvfsapnylgrlgnlgavlaldeglvwgfklfa
subfamily_PPP1C_pd Subfamily PPP1C 51-325 1.9e-87 286.1 In-house 9-270 (282) alignment 
Range on Protein: 51-325
Range on HMM: 9-270/282.0
RLEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECR
.|.|.   ....   .|| .. ...|..||....||||||. ||..||| .|.|....||||||||||| .|.| .. | ..||..|..|||||||||. 
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesa

HLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDygnektLEHYTHNTvR
... .. |. ||. .|| ... . ...|.|||||||.... ||||||.|||..||..|||. | .| |  | .|||||||| ..       . ...|. |
sinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdke......vlgwsend.r

GCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
| |. ..  .| .|||.|.|  |.|||.  ..||... | |      |.|.||||||.. ..|..|||. .....
GvsftfgkdvvekflqkndldlivrahqvvedGyeffakrq......lvtvfsapnycgefdnagavlsvdeell
subfamily_PPP4C_pd Subfamily PPP4C 52-325 1e-82 270.6 In-house 16-276 (288) alignment 
Range on Protein: 52-325
Range on HMM: 16-276/288.0
LEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRH
..||   .. ..   || .|  . .||.|.||||||||||.||..||.|||.  .|.||||||.||||..|.|. | | .||. .|. . |.|||||.|.
ikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrq

LTDYFTFKQECRIKY-SEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGnektlehYtHNTVR
.|  . | .||  || | .|.  |.| || |.|||..... .|||||.||.|..||.|| .|| .| |  ||.|||||||| .  |       .   . |
itqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaeg.......w.avspr

GCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
|  |..   .| .| ..|..  |.|||.    ||... . .      ..|..|||||     |.||.|...... 
gagylfgsdvveqfneandielicrahqlvmegyklhfnek......vltvwsapnycyrcgnvaaileldeeld
subfamily_PPP2C_pd Subfamily PPP2C 39-334 3.7e-80 262.2 In-house 4-287 (290) alignment 
Range on Protein: 39-334
Range on HMM: 4-287/290.0
VDVLKNHLVKEGRLEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPK
.| | ..| .  .|||.   ....    ||..|. . || .|.|||||.||||.||..|| .||.  .| ||||||||||||.|.|.| .| .||. ...
ldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvryke

TLFLLRGNHECRHLTDYFTFKQECRIKYSE-QVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGn
 . .|||||| | .|. . | .||  ||.. .|.    . ||.|||.||...| .|.|||.||.|..||.||.|||. | |  ||.|||||||| .  | 
ritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrgg.

ektlehYThNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQFNCSP
      ..  . ||. | .      .| ..|.|  |.|||.    ||..  . .      ..||||||||     |.||.|. .... ... ||. .|
......wg.isprgagytfgkdisekfnktngltliarahqlvmegynwshdrn......vvtifsapnycyrcgnqaailelddklkysflqfdpap
subfamily_PPP5C_pd Subfamily PPP5C 44-338 7e-80 261.4 In-house 26-314 (322) alignment 
Range on Protein: 44-338
Range on HMM: 26-314/322.0
NHLVKEGRLEEEVALKIINDGAAILRQEKTMIEVDAP----ITVCGDIHGQFFDLMKLFEVGGSPSNT-RYLFLGDYVDRGYFSIECVLYLWSLKINHPK
... |. .|.. .||||. .  ..|... ...|.. .    .||||||||||.||. .||. |.||..  ||| ||.|||| ||.|..| |...|. .|.
elfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPn

TLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGM-SPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGN
 .|| |||||  ..   . |..|.. ||.|.|.|   |.|. |||| ..|...| ||||. | .  .|||.||.||...||  | ...|||||| |  | 
hfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGr

EKtlehythnTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKY--ENNVMNIRQFNCSPH
 .        . || .  .      .||..|||  |||.|| .. ||.. .. .      |||.|||||| |  .||.|...   ... .....|.  .|
sp........skrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGk......litvfsapnycdqmgnkgafitlrgddlklkfktfeaveh

PYW
|  
pdv
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 52-325 3.3e-77 252.4 In-house 24-285 (298) alignment 
Range on Protein: 52-325
Range on HMM: 24-285/298.0
LEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRH
..||   |.|.    |... |...||||||.||||||||. ||..||. .| | .. ||||||||||| ...| .. | . |...|. .||||||||| .
ikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnhecea

LTDYFTFKQECRIKY-SEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSedygneKTLEHYTHNTvR
.   . |..||. .| | ..| .  ..|. |||.||. .. ||.|||.|....|||..|.| | ....    . ||||.||.      .... ...|. |
inrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpe......navkgwaens.r

GCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
| |. .   .| ..|.. ..  ..|||     || .. . .      |.||||||.|.. ..| |||.| .....
GvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekk......lvtifsaphycgqfdnsaavmkvdeklv
subfamily_PPP6C_pd Subfamily PPP6C 52-330 8.1e-73 238.1 In-house 15-281 (290) alignment 
Range on Protein: 52-330
Range on HMM: 15-281/290.0
LEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRH
| |. . |. .  . .| .| ..  | .|.||||||||||.||..||  ||.  .|.|.||||.|||||.|.| . .| .||...|. . |||||||.|.
lpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrq

LTDYFTFKQECRIKYSE-QVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPsEDygnektLEHYTHnTVR
.|. . | .||  || . ...  |.. || |..||....| ||||||.||... ||.|| ..| .| |  |..|||.|||| ||      .|...  . |
itqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.ed......vetwav.spr

GCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQF
|  |..    . ||...|||  |.|||.  . |.. . . .      |.|..|||||     | |..|. |..   . . |
gagylfgskvtkefvhinnlklicrahqlveeglkymfdek......lvtvwsapnycyrcgnvasilaledaeereaklf
PPP_4 81-280 2.3e-72 236.2 In-house 1-197 (197) alignment 
Range on Protein: 81-280
Range on HMM: 1-197/197.0
ITVCGDIHGQFFDL-MKLFEVGGSPS-NTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETF
.||.||||||..|| .||...|| || ...|.|||||||||..|.|..|.|..||.. ||...|||||||...|. ...||.|.  |............|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

DCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPP-AFGPVCDL-LWSDPSedygneKTLEHyTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRA
|.||||||.....|.||||.|.|..|||.|....|..| |   .  .|| |||||.      .. |. ..|.|||....... ....||..||| .|||.
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpr......eaqeg.lansvrGagllFgpdvtekfleknnlkliirs

HEAQ
||..
helk
PPP_2 81-279 1.9e-71 232.8 In-house 1-197 (198) alignment 
Range on Protein: 81-279
Range on HMM: 1-197/198.0
ITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECR-IKYSEQVYDACMETFD
.|||||.|||. ||..||..|.......|||||||||||..|.|..|.|..||...||...|||||||.........||.|.   |....||....|.|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

CLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLwsdPSEDYGNEKTLEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEA
.||||||.....|.||||.|.||..||.|.| .|..| |. |...|||   ..|.. ..|. |. ..|..||......  ...|.|..|.|  ||||||.
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldll...eeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_PPG1_pd Subfamily PPG1 54-323 5.4e-71 232.3 In-house 15-285 (300) alignment 
Range on Protein: 54-323
Range on HMM: 15-285/300.0
EEVALKII-NDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHL
 ||..| . .    .| .|  .||. .|.|| ||.||||.|....|..||   .| |||||||||||..|.| .  |  ||. .|  . ||||||| | .
pevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqi

TDYFTFKQECRIKY--SEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDygNEKTLEHYTHN---
|. . |  ||  ||    .|..   | || | |||.....  |||||.||.. |.|.|. |||| | |  | ..||||||| |.  |. ||.|  ..   
tqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeen..nnptldhpdregqh

---TVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENN
   . ||. | |    | .||.||..  |||||.    ||...  ..      | |..|||||     |||..|. ...
fvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnk......lstvwsapnycyrcgnkasilelyek
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 59-323 8.2e-69 224.8 In-house 13-264 (280) alignment 
Range on Protein: 59-323
Range on HMM: 13-264/280.0
KIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTF
..|.    ||  ..||.|||||..||||.|||. ||..||.  . | .. ||||||||||| . .| .| | . |. .|.....||||||. .. . . |
rviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygf

KQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDygnektLEHYTHNTvRGCSYFYSY
|.|.. .||...|.   | .| |||.||.. . ||.|||.|... ||||...| |  ...      ||||.||...      .  ...|. ||.|. .  
kdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenk......vtgwaens.rgvsvifga

PAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENN
  | .. .  ..  |.| |.  . || .. . .      |.|.||||.||. ..|.||||. ...
nvvkdltekldidliarghqvvqdgyeffadkk......lvtvfsapkylgefdnsaavlivder
PPP_5_Dcr2 81-279 2.1e-68 223.2 In-house 1-198 (199) alignment 
Range on Protein: 81-279
Range on HMM: 1-198/199.0
ITVCGDIHGQFFDL-MKLFEVGGSPS-NTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIK-YSEQVYDACMET
.|||||.|||..|| ..||. || || ...|.|||||||||..|.|..|.|..||.. ||...|||||||...|. ...|..|.  | .....|... ..
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPP-AFGPVCDL-LWSDPSedygneKTLEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIR
||.||||||.....|.||||.|||| |.....|..|..| |   |  .|| |||||.      .. |..  |..||....... ....||..|||  |||
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdpr......daqegcklnseRGagllfgpdvtekfleknnlkliir

AHEA
.||.
shel
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 56-322 5.1e-68 222.1 In-house 14-270 (287) alignment 
Range on Protein: 56-322
Range on HMM: 14-270/287.0
VALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDY
  |....    ||.  ....||.||||..||||||. ||...|.  | .....|||||||||||  |.| .|.|.||||  || . |||||||....   
dilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinkl

FTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAF--GPVCDLLWSDPSEDygnEKTLEhytHNTVRGCS
. ||.| . |..|..|    . |. ||| | .... ||.|||.||.. |||... | . | | |   | . ||||.||..|    ||.|    | .|. |
yGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd...aktfe...lnkirais

YFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYEN
  .    | ..|.. ..  |.|||| .. || .. . .      |.|.|||| |     | .||.. ..
vvfGkkevddllkkldidlivrahevseeGyaflfdkr......lvtvfsapyysgedtnlgavvvvsk
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 67-325 2.7e-67 220.2 In-house 23-274 (284) alignment 
Range on Protein: 67-325
Range on HMM: 23-274/284.0
ILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSP------SNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQ
.. .||  .|..||....||||||| ||. |... | |       ...||||||||||| |||| .. |...|. .|. .|||||||| | .   . | .
lfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyl

ECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEdygnekTLEHYThNTVRGCSYFYSYPA
||. .|||..|.|   .| ..||.|..... .|.|||.| .. .|... ||.| .. |  | ..|| |.||..      ..|.|. .. ||.   .   |
eckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpea......evegyk.esprgagkvfgaka

VCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
| |||.. .|  ..|||.    || ..   .      |.|||||| |   ..| ||||. .....
vkeflkkfkldlvvrahqvvmdgyeffadrk......lvtifsapsycgqldniaavlnvdeelv
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 57-324 1.5e-66 217.5 In-house 13-267 (281) alignment 
Range on Protein: 57-324
Range on HMM: 13-267/281.0
ALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYF
  ..|    ||. .||...|.|.||.| ||.|.|| || .|||. | .......|||||||||  |.|... |..||| ... ..|||||||  ..   .
ienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiy

TFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEdygneKTLEhYTHnTVRGCSYFY
 | .||  || |...    . |. ||..|| ... ||.|||.|||.|.||..|.  .  ...  | | ||||.||..     |. | . . ..|| |. .
gfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdn.....kvee.wka.ssrGssftf

SYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
    | .  .. ..  |||||    .||..    .      |||.||.||| . |.| ||||| ....
GknvvddvckrleveliirahqvvqdGyevlsgrk......litvfsvpnycafyknaaavlkvdetl
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 66-325 3.8e-64 209.8 In-house 38-285 (299) alignment 
Range on Protein: 66-325
Range on HMM: 38-285/299.0
AILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIK
 .. .. ...||.||| ||||||||. ||...|.. | | .. .||||||||||   .| .  |   ||..|. .|.|||||||  .   . | .||  .
svfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecnkr

Y-SEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPsedygnEKTLEHYTHNtVRGCSYFYSYPAVCEF
| | ... .  ..|. .||. |.. . ||.|||.||....|| .|.| |  .||.     ||||.||      ....  .  | ||| || .    | . 
ykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadp......dqsvkdwlan.vrgvsyvfgqdvvadv

LQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
... ..  . |||.  . || .. . .      |.|||||| |   ..| ||..| ..|..
isrldidlvarahqvvqdgyeffaskk......lvtifsaphycgqfdnsaaimkvdenlv
subfamily_PPZ_pd Subfamily PPZ 52-322 1.2e-63 208.4 In-house 25-282 (300) alignment 
Range on Protein: 52-322
Range on HMM: 25-282/300.0
LEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRH
|...  |.|      ..  . ...|.  .. . ||.|||. ||..||   | |  . |||||||||||  |.| .| |.  ||..|. .|||||||||  
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecan

LTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSeDYGNEktlehYThNTVRG
.|  . | .||. .   ... . ..||. |||||..  . .|||||.|| . |.|.||.. | |. | || . |||||||. |  ||     .  .  ||
vtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdpt.dssne.....we.dnerg

CSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSqatgfpSLITIFSAPNYLDVYNNKAAVLKYEN
 || |   |. .||..  .  . |||   . || ..         ||.|.||||||   ..|  ||.   .
vsycynkvainkflnkfgfdlvcrahmvvedgyeffndr......slvtvfsapnycgefdnwgavmsvse
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 52-322 5.4e-62 202.7 In-house 23-283 (297) alignment 
Range on Protein: 52-322
Range on HMM: 23-283/297.0
LEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRH
. ||  ||...    .....|.|.||.||| ||||||||| ||..||  || |  . ||||||||||| |||| .. | . |.. |  ||||||||||  
iteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecef

LTDYFTFKQECRIKY-SEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPE---ITSLDDIRKLDRFTEPpAFGPVCDLLWSDPSEdygnekTLEHYTHN
.   . | .||. .| | ..| |  . |. |||. |. .. ||.|||.||      .|| .||..| ||    . |.||||.||         |  . .|
vnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpis......glsgfmen

TvRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYEN
  ||.   .   || .   . .|  . |||.  . || ..   .      |.|||||| |   ..| ||..  ..
q.rgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrk......lvtifsaphycgqfdncaafmscde
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 57-324 5.1e-59 192.9 In-house 11-290 (302) alignment 
Range on Protein: 57-324
Range on HMM: 11-290/302.0
ALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVG-----------GSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRG
 |..|.   . |..|||..|. .|.|. ||||||| ||....               | |. ...|||||||||. ||||.  ...||. .|.   ||||
llllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrg

NHECRHLTDYFTFKQECRIKYSEQ----VYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAF-GPVCDLLWSDPSEDYGNE--
|||.. .   ..|..|  ......    ...   |.|  .|||||. .. ||||||.|| ..||.||.|..|  .  .      |||..|| .  .    
nhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaav

KTLEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
..  .|..|.||| |. .   || .. .. ||  |.|||    .|.... . .      |.||||||.|..  .|| |||| . | 
sekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 57-324 8e-59 192.3 In-house 12-291 (302) alignment 
Range on Protein: 57-324
Range on HMM: 12-291/302.0
ALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVG-----------GSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRG
 |..|.   . |..|||..|. .|.|. ||||||| ||....               | |. ...|||||||||. ||||.  ...||. .|.   ||||
llllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrg

NHECRHLTDYFTFKQECRIKYSEQ----VYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAF-GPVCDLLWSDPSEDYGN--E
|||.. .   ..|..|  ......    ...   |.|  .|||||. .. ||||||.|| ..||.||.|..|  .  .      |||..|| .  .    
nhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaav

KTLEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
..  .|..|.||| |. .   || .. .. ||  |.|||    .|.... . .      |.||||||.|..  .|| |||| . | 
sekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 106-324 1.3e-58 191.6 In-house 100-305 (317) alignment 
Range on Protein: 106-324
Range on HMM: 100-305/317.0
NTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSL
. .||||||||||| |||| |. | .||. .|. .|||||||| | .   . | .|.. .||...|.|   .| .|||.|..|.. ||.|||.| |...|
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldl

DDIRKLDRFTEPPAFGPVCDLLWSDPSEdygnekTLEHYtHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAP
. . ||.| .. |  | ..|| |.|| .      . ..| ... || .  .  .|| |||.. .|  ..|||.    || ..   .      |.||||||
kqldklkrpldipdvGvladltwadpda......evkgy.kesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrk......lvtifsap

NYLDVYNNKAAVLKYENNV
.|    .| ||||. ....
sycGqldniaavlsvdkkl
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 53-320 9.6e-57 185.2 In-house 17-275 (290) alignment 
Range on Protein: 53-320
Range on HMM: 17-275/290.0
EEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHL
...  |.|..    ||.   ...|| |||.. ||||||. .|.. |.  | | . ..||||||||||  |.|  |.|. .|| ..|.. |||||||.|..
sdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkv

TDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPP--AFGPVCDLLWSDPSEDYGNekTlehYTHNTVR
   . ||.|   | . ...    . |. |.| | .... ||.|||.|..| | . .. | .   |     | . ||||.||..|  .  |   .. |  |
nrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkdd..t...ialnkqr

GCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKY
. |  .   .. ..|..  |  |.|||| .. |. .  . .      |.|.|||| |     |  |... 
aisvvfgkkglddllkklalslivrahevkeegfnflfdkk......lvtvfsapyysgndtnlgaiatv
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 61-324 1.7e-56 184.7 In-house 12-264 (284) alignment 
Range on Protein: 61-324
Range on HMM: 12-264/284.0
INDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQ
. .  .|. ..  .|||..|| .|||||||| ||..||.  | |  . |||||||||||   .| .| |.. |.  |. .|.|||||||  .   . | .
lfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfye

ECRIKYSE-QVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDR-FTEPPAFGPVCDLLWSDPSEdygNEKTlehYTHNtVRGCSYFYSY
||. .| .  || .    |  .||.||. |. ||.|||.|  .  . ..| . | | .|       |.|||||..    .|    .  |  || || .  
ecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptn...fqkg...wnpn.srgvsyvfgs

PAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
 |. ..|.  ..  ..|||.  . || .. . .      |.|||||| |   ..| |||.  ..|.
dalrklldrlqidlvvrahqvvqdgyeffanrr......lvtifsapfycgqfdnaaavmyvnknl
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 58-330 9.3e-56 182.3 In-house 12-272 (280) alignment 
Range on Protein: 58-330
Range on HMM: 12-272/280.0
LKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFT
. ||    ||. .|  ..| .||| | |||| |. |. .||.. |   . . .|||||||||   || .. |. ||| .   ..|||||||   .   . 
iaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiyg

FKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDyGnektlEHYTHnTVRGCSYFYS
|  ||. ||   ..      |. .|...|.... ||.|||.|||.  || ||.. |  ||   | . |||||||..  |     | . | ..|| ||.. 
fyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnk.g.....egwfh.sirgisymfg

YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYrksqaTGfPSLITIFSAPNYLDVYNNKAAVLKYENNVM-NIRQF
   | .  .. ..  |||||.  . || |      .|   |||.|| |||   . | |||.  . |.  ...|.
kgvveqacksleidliirahqvvqdgyemm.....ag.rrlitvfsvpnycaqftnaaavvclnanlqvsfqql
subfamily_PPPLV_pd Subfamily PPPLV 60-325 1.8e-53 174.8 In-house 5-281 (290) alignment 
Range on Protein: 60-325
Range on HMM: 5-281/290.0
IINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLM----KLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDY
. .    || .|. ..|...|. | ||.||.. ||.    .|. .|   . . .|||||||||| ||.| . || .||.  |  ..||||||| . ... 
lcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqes

FTFKQECRIKYSEQ---VYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRK----LDRFTEPPAFGPV-CDLLWSDPSEDY-----GNEKTLE
...| |.  |. ..   |..| ...|| ||||| .... .|||.|.   | .   |      |.|. ..    |.  |.|||||.||      |.  . |
ieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlne

HYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
 . .|  || .. .|  |.  ||..|||  ..||||....|.|. .|..      |.|.||. .|    |. | .|  .... 
GfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgr......lltvfsssrycGssneaalilvdkkklr
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 57-323 6e-52 169.7 In-house 25-281 (307) alignment 
Range on Protein: 57-323
Range on HMM: 25-281/307.0
ALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYF
  ..| .  .|.  ||.....| |  | ||.|||| ||...| . | | .| |.| ||||||| .|.||.| |.. || .|. . |||||||  ..   .
fenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkky

TFKQECRI---KYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDygnekTLEHYThnTVRGCS
.| .||     |  |...      |. ||..||.  . ||.|||.|| .| ||..|.  .    |  | | |.||.||         .|  .  . ||  
gfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdps.....vfewka..ssrgsg

YFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSqatgfpSLITIFSAPNYLDVYNNKAAVLKYENN
. .    . .  .   .  |||||.    || .           |||||||| | ..|.|  .||| .. 
ftfgtnviddvckrlgveliirahqmcfdgywvlsgr......klitifsapmycnfyknagcvlkvdet
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 74-320 2.1e-51 168.1 In-house 2-242 (263) alignment 
Range on Protein: 74-320
Range on HMM: 2-242/263.0
MIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYS-----E
..|..||| .||| |||. ||...|.  |. ..|.||||||||||| .|.| .. |.|||.  |. ..||||||| . .   . |. | . ..      |
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

QVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGP-VCDLLWSDPSEDygnektLEHYTHNTVRGCSYFYSYPAVCEFLQN
 ||.   . |  .||.|..... ||.|||.|| . |||||| .    |     |  |||||.|| .|       . .  | .|  |  .    | .. . 
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekd......akgfepnkiraisnvfgkkevddlckr

NNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKY
 ..  |.|||.  . || ..   .      |||.|||  |     | |||.  
ldidlivrahqvveygyaffadrr......litvfsasryqielcnyaavvvv
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 107-323 1.4e-46 152.1 In-house 120-323 (339) alignment 
Range on Protein: 107-323
Range on HMM: 120-323/339.0
TRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLD
 |||||||||||| ||.| |. | .||. .|  ..||||||| | .   . | .|   .|  |.|..  . |. .|..|..|.  .|.|||.|  .||..
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

DIRKLDRFTEPPAFGPVCDLLWSDPSEdygNEKTlehYtHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPN
..  . |  | |  | . || |.||      ||    | . . ||.|. .  ||.  ||.. .|  .|| |.  . || ..   .      |.|||||||
qfsvfkrpleipdvgvltdltwadpdp...tekg...y.kpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrr......lvtifsapn

YLDVYNNKAAVLKYENN
|    .| |||.  ...
ycgqndntaavfsidkk
Metallophos Calcineurin-like phosphoesterase 80-280 2.7e-43 141.6 Pfam-A 2-199 (200) alignment 
Range on Protein: 80-280
Range on HMM: 2-199/200.0
PITVCGDIHGQFFDL----MKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYL--WSLKINHPKTLFLLRGNHECRHLTDYFTFKQECR----------
.|.|.||.||.. ||    ..|....... .. .|||||.||||  |.|.  .|  ..||.. |. .||||||||........ |. |.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------IKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIrkldrfteppafgpvcdllwsdpsedygnek
                         ..   ..... |.|..|||.|| ....|..||..|..  | |||                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

tlehythntvrgCSYFYSYPAVCEFLQNNNLLSIIRAHEAQ
            .|. ....|....|.....  ..|.|. .
............gselfgpdalekllekygvdlvlrGHtHk
subfamily_PPP7C_pd Subfamily PPP7C 38-213 2.7e-34 111.5 In-house 19-201 (383) alignment 
Range on Protein: 38-213
Range on HMM: 19-201/383.0
KVDVLKNHLVKEGRLEEEVALKIINDGAAILRQEKTMIEVDA----PITVCGDIHGQFFDLMKLFEVGGSPSNT-RYLFLGDYVDRGYFSIECVLYLWSL
.|. | ... .. .|  .  |.|. . . .|.| . . .| .     .|||||.||.. ||. ..   | ||.   |.| ||.||||  |.| .| | .|
eveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillal

KINHPKTLFLLRGNHECRHLTDYFTFKQECRIKY---SEQVYDACMETFDCLPLAALLNQQFLCVHGGMSpEITSLDDIRKLDR
 . .|| ..| |||||   |   . | .|   ||   ....     . |  ||||.|.... | ||||.| ..|.|. . |..|
llvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkier
subfamily_PPP7C_pd Subfamily PPP7C 223-325 2.2e-13 42.7 In-house 237-326 (383) alignment 
Range on Protein: 223-325
Range on HMM: 237-326/383.0
VCDLLWSDPSEDYGNektlehyTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYEN
| |.||||| .. |        . ||.||   ..      ..||. ||  .||.|| .  || .  ...      ..||||| || ..  |. | .|  .
vldilwsdpkakeGc.......kpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkk......vltifsasnyyeeGsnrGayvklgk

NVM
...
dlt
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 67-105 4e-10 32.3 In-house 24-62 (317) alignment 
Range on Protein: 67-105
Range on HMM: 24-62/317.0
ILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPS
.. .|. ..|..||.|..||||||| ||. |... | | 
lfwkeplkleleapvtivGdihGqfedllalldlnGwpl
subfamily_YNL217W_pd Subfamily YNL217W 81-162 3.5e-07 23.0 In-house 12-89 (235) alignment 
Range on Protein: 81-162
Range on HMM: 12-89/235.0
ITVCGDIHGQFFDLMKLFE--VGGSPSNTRYLFLGDYVDRGYFSIECVLYLwslkinHPKTLFLLRGNHECRHLTDYFTFKQEC
. | ||.|| . .|..|..  .||   |   ...|| ...|  |.| | |.      . .    ..||||   |  |   |.. 
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 68-105 2.5e-06 19.8 In-house 27-64 (339) alignment 
Range on Protein: 68-105
Range on HMM: 27-64/339.0
LRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPS
.  |  .....||| | ||||||| ||. .... | | 
iwsepiflkleapicvmgdihgqfddllamldmngwpl